CN106173409A - A kind of ablactational baby pig feed additive and preparation method thereof - Google Patents
A kind of ablactational baby pig feed additive and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of ablactational baby pig feed additive and preparation method thereof, wherein feed additive includes following raw medicinal material: Ganoderma, Radix Salviae Miltiorrhizae, Proceras venosata Walker, Herba Tagetis Patulae, bitter mustard, Tricholoma mongolicum Imai, Caulis et Folium Chrysanthemi segeti, Formica fusca, Fructus Atriplicis Sibiricae and Radix Isatidis.The invention has the beneficial effects as follows: the feed additive of the present invention is applicable to prevent piglet infectious bulbar paralysis, it is used in combination with low virus vaccine or sensitized vaccine, contagious pleuropneumonia can not only be prevented and treated, but also immunity and the resistance against diseases of piglet can be improved, there is the advantage that prevention effect is good, safety is high, have no side effect.
Description
Technical field
The present invention relates to pig's feed additive, particularly to a kind of ablactational baby pig feed additive and preparation side thereof
Method.
Background technology
Pig transmissible encephalomyelitis (Swine infectious encephalomyelitis, SEM) is by Intestinum Sus domestica virus
The impaired infectious disease that a series of nervous symptoms occurs then of central nervous system caused.Face and examine with quadriplegia and felt
Quick, tremble, the cranial nerve symptom such as paresis, convulsions is principal character.Often may result in suckling pig dead.Primary disease nineteen twenty-nine as far back as
Former Czechoslovakian prompt area, Shen finds, therefore it is sick to be also called prompt Shen.Also known as tower kind disease, Medulla sus domestica poliomyelitis, swine diseases
Toxicity encephalomyelitis etc..
Pig transmissible encephalomyelitis is divided into acute, subacute type, chronic type and recessive type.Wherein, acute viral brain
Myelitis is due to virus virulence and the difference of inoculum concentration, and its, scope was 4～28 days incubation period.Their early stage body temperature raises, up to
41～42 DEG C, the highest.Sick pig spirit is poor, anorexia, hind leg incoordination.Development along with the state of an illness, it may appear that encephalitis disease
Shape, as stiff in extremity, eyeball trembles, twitching clonism even occurs.Opisthotonus is there will be when being upset.Sick pig one
As after symptom occurs 3～4 days dead.Single cases can delay the several months or not dead, but often can leave amyotrophy and paralysis
Sequela.Subacute infection encephalomyelitis, symptom is gentleer, and M & M is relatively low.Seeing and symptom in 14 ages in days
The most serious.Most pigs are more.Extremely children age pig M & M up to 100%, 3 week old with the less morbidity of pig.This disease is sent out
Raw rapid, disappear the rapidest.Sick pig appetite is depressed, and body temperature slightly raises.Occur after the nervous symptoms usual a few days.In 14 ages in days
Piglet performance hyperesthesia, ataxia, draw back, in sitting position of dog gesture, encephalitis symptom eventually occurs.
Because the sick pig that encephalomyelitis is dead cuts open the visible meninges edema of inspection, meninges and cerebrovascular are congested, and cardiac muscle and skeletal muscle are slightly
There is atrophy.Other organs is visible by naked eyes change.Intestinal mucosa is without specific lesions.Histologic lesion is distributed mainly on nervous gray
In, cornu ventrale medullae spinalis, cortex of cerebellum, diencephalon etc. are the most obvious.It is mainly characterized by neuron degeneration, necrosis, bites neural thin
Born of the same parents' tuberosity is formed, and blood vessel peripheral lymphocyte infiltrates, and forms lymphocyte set.Mainly encroach on cervical spinal cord in early days, then develop
To breast, waist and pars coccygea medullae spinalis.The pathological changes of brain is slighter.
At present, symptomatic treatment is mainly taked after swinery morbidity, it is also possible to rehabilitation porcine blood serum is treated, but effect is unsatisfactory.
Must make a definite diagnosis rapidly during swinery morbidity, sick pig be carried out and slaughters or full group eliminates, suppose in group health pig carry out strict isolation and
Observe, remove doubtful sick pig in time, other are not found that infected healthy swinery carries out strict block, strengthens sterilization.Primary disease
There is no preferable Therapeutic Method, how to put prevention first.At present prevention primary disease introduced pigs can be used strictly to quarantine, fall ill swinery and
Time diagnosis, isolate and slaughter, the general measure such as strict sterilization.Abroad have been reported that available hydrogen aluminium oxide inactivated vaccine, weak poison epidemic disease alive
Seedling and cell are cultivated inactivated vaccine and are carried out immunity inoculation, and the former protective rate is low, and the protective rate theory of attenuated live vaccines is preferably able to
Reaching 80%, duration of immunity is 6～8 months.
Summary of the invention
The technical problem to be solved is, it is provided that a kind of ablactational baby pig feed additive and preparation side thereof
Method, this feed additive is Chinese medicine additive, it is possible to well prevention pig transmissible encephalomyelitis, reduces sickness rate, and has
The advantage that safety is high, have no side effect.
In order to realize foregoing invention purpose, the invention provides a kind of ablactational baby pig feed additive, described feedstuff adds
Add agent and include following raw medicinal material: Ganoderma, Radix Salviae Miltiorrhizae, Proceras venosata Walker, Herba Tagetis Patulae, bitter mustard, Tricholoma mongolicum Imai, Caulis et Folium Chrysanthemi segeti, Formica fusca, Fructus Atriplicis Sibiricae and Baphicacanthus cusia
Root.
Described feed additive is made up of the raw material of following parts by weight: Ganoderma 10-20 weight portion, Radix Salviae Miltiorrhizae 10-15 weight
Part, Proceras venosata Walker 12-25 weight portion, Herba Tagetis Patulae 14-21 weight portion, bitter mustard 10-20 weight portion, Tricholoma mongolicum Imai 5-10 weight portion, Caulis et Folium Chrysanthemi segeti 3-9
Weight portion, Formica fusca 3-7 weight portion, Fructus Atriplicis Sibiricae 8-15 weight portion and Radix Isatidis 10-20 weight portion.
Described feed additive is preferably made up of the raw material of following parts by weight: Ganoderma 15 weight portion, Radix Salviae Miltiorrhizae 12 weight
Part, Proceras venosata Walker 18 weight portion, Herba Tagetis Patulae 17 weight portion, bitter mustard 15 weight portion, Tricholoma mongolicum Imai 7 weight portion, Caulis et Folium Chrysanthemi segeti 6 weight portion, Formica fusca 5 weight
Amount part, Fructus Atriplicis Sibiricae 11 weight portion and Radix Isatidis 12 weight portion.
Described feed additive also includes: Poria, Folium Violae Acuminatae, Apis room, long pine and Semen Euryales.
Described feed additive is preferably made up of the raw material of following parts by weight: Ganoderma 10-20 weight portion, Radix Salviae Miltiorrhizae 10-
15 weight portions, Proceras venosata Walker 12-25 weight portion, Herba Tagetis Patulae 14-21 weight portion, bitter mustard 10-20 weight portion, Tricholoma mongolicum Imai 5-10 weight portion,
Caulis et Folium Chrysanthemi segeti 3-9 weight portion, Formica fusca 3-7 weight portion, Fructus Atriplicis Sibiricae 8-15 weight portion, Radix Isatidis 10-20 weight portion, Poria 10-15 weight
Part, Folium Violae Acuminatae 6-15 weight portion, Apis room 4-6 weight portion, long pine 5-10 weight portion and Semen Euryales 12-16 weight portion.
Described feed additive is preferably made up of the raw material of following parts by weight: Ganoderma 15 weight portion, Radix Salviae Miltiorrhizae 12 weight
Part, Proceras venosata Walker 18 weight portion, Herba Tagetis Patulae 17 weight portion, bitter mustard 15 weight portion, Tricholoma mongolicum Imai 7 weight portion, Caulis et Folium Chrysanthemi segeti 6 weight portion, Formica fusca 5 weight
Amount part, Fructus Atriplicis Sibiricae 11 weight portion, Radix Isatidis 12 weight portion, Poria 12 weight portion, Folium Violae Acuminatae 11 weight portion, Apis room 5 weight portion,
Long loose 7 weight portions and Semen Euryales 14 weight portion.
In order to preferably realize foregoing invention purpose, the invention provides the preparation method of a kind of feed additive, specifically
For:
The first step, will be mixed in proportion by other described raw medicinal material in addition to Caulis et Folium Chrysanthemi segeti, add relative to mixture quality 2～4
The ethanol that determining alcohol is 85～95% again, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter and obtain
Medicinal residues add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 little
Time, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent,
It is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, obtain
Obtain 300 mesh～the micropowders of 400 mesh；
3rd step, after Caulis et Folium Chrysanthemi segeti is placed in dehydrator drying, then is ground into powder and obtains Caulis et Folium Chrysanthemi segeti powder；
4th step, by second step obtain micropowders and the 3rd step obtain Caulis et Folium Chrysanthemi segeti powder mixing, be subsequently adding relative to
Micropowders and Caulis et Folium Chrysanthemi segeti powder mixing quality 2～the starch of 4 times, mixing, it is thus achieved that powder.
The invention has the beneficial effects as follows: the feed additive of the present invention is applicable to prevent piglet infectious bulbar paralysis, with
Low virus vaccine or sensitized vaccine are used in combination, and can not only prevent and treat contagious pleuropneumonia, but also can improve piglet
Immunity and resistance against diseases, have the advantage that prevention effect is good, safety is high, have no side effect.
Detailed description of the invention
The invention provides a kind of ablactational baby pig feed additive, including: Ganoderma, Radix Salviae Miltiorrhizae, Proceras venosata Walker, Herba Tagetis Patulae, hardship
Mustard, Tricholoma mongolicum Imai, Caulis et Folium Chrysanthemi segeti, Formica fusca, Fructus Atriplicis Sibiricae and Radix Isatidis, it is preferable that also include Poria, Folium Violae Acuminatae, Apis room, long pine and Semen Euryales.
Wherein, the pharmacological property of above-mentioned raw materials is as follows:
Ganoderma: sweet, flat.GUIXIN, lung, liver, kidney channel.Function cures mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizziness sleeplessness, the heart
Throb with fear and breathe hard, asthenia cough with asthma.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menstruation not
Adjusting, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.
Proceras venosata Walker: another name: striped stem borer [adult name], sorghum stem borer.Source: Insecta Lepidoptera Pyralidae Sorghum vulgare Pers. bar
Snout moth's larva Diatraea venosata (Walker), is used as medicine with larva.Habitat branch: various places, northeast.Function cures mainly: removing heat from blood, removing toxic substances.
Herba Tagetis Patulae: another name: little marigold, reddish yellow Flos Tagetis Erectae, reddish yellow Flos Hibisci Mutabilis careless, little, rattan chrysanthemum.Source: Compositae Flos Tagetis Erectae
Platymiscium Herba Tagetis Patulae Tagetes patula L., with all herbal medicine.Xia Qiu gathers, and cleans and dries.Nature and flavor: bitter are flat.Function master
Control: clearing away heat-damp and promoting diuresis, cough-relieving, pain relieving.For upper respiratory tract infection, dysentery, cough, pertussis, toothache, acute conjunctivitis due to pathogenic windfire；External is controlled
Parotitis, mastitis.
Bitter mustard: nature and flavor: bitter；Cold.Return spleen；Stomach；Bladder warp.Function cures mainly: clearing away heat and cooling blood；Diuresis removing food stagnancy.Main high heat；Urine
Unfavorable；Stop in Ji Zhi；Abdominal distention.
Tricholoma mongolicum Imai: nature and flavor: sweet；Pungent；Property flat.Return lung；Spleen；Stomach warp.Function cures mainly: spleen invigorating qi-restoratives；Lung qi dispersing cough-relieving；Rash.Main
Dizzy weak；God is tired indigestion and loss of appetite；Dyspepsia；Cough and asthma；Measles is intended to；Dysphoria.
Caulis et Folium Chrysanthemi segeti: enter spleen, stomach warp.1. " book on Chinese herbal medicine must be joined ": " enter Foot yangming Channel." 2. " book on Chinese herbal medicine is looked for the truth ": " enter the heart, spleen, intestinal, stomach,
Kidney." function cures mainly: and taste, profit two just, drink by expectorant.1. " dietetic therapy of dry gold ": " gas of feeling at ease, supports taste, and expectorant is drunk." 2. " day
With book on Chinese herbal medicine ": " disappear water paddy." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " row irritability, controls swelling and hanging down of either of the testes gas pain, diuresis." 4. " book on Chinese herbal medicine must be joined ": " profit intestinal
Stomach, promoting blood circulation, except the disease due to obstruction of QI of middle-JIAO foul smell."
Formica fusca: salty in the mouth；Acid；Property flat.Return liver；Kidney channel.Function cures mainly: the kidney invigorating and essence nourishing；Dredge the meridian passage；Removing toxic substances and promoting subsidence of swelling.Main kidney
Deadhead dusk tinnitus；Insomnia and dreamful sleep；Impotence and seminal emission；Rheumatic arthralgia；Apoplectic hemiplegia 6；Numb hand and foot；Lupus erythematosus；Scleroderma；Skin
Myositis；Carbuncle furuncle；Venom.
Fructus Atriplicis Sibiricae: bitter is flat.1. " Shandong Chinese herbal medicine handbook ": " bitter, temperature." 2. " Inner Mongol Chinese herbal medicine ": " bitter micro-acid is salty,
Flat." function cures mainly: dispel the wind, and invigorates blood circulation, liver heat removing, improving eyesight.Control and combine film inflammation, headache, skin pruritus, toxic swelling, galactostasis.1. " mountain
East Chinese herbal medicine handbook ": " dissipate wind, improving eyesight.Control and combine film inflammation, rubella pruritus." 2. " Inner Mongol Chinese herbal medicine ": " liver heat removing and eyesight improving, dispels the wind
Invigorate blood circulation, detumescence.Control headache, skin pruritus, toxic swelling, galactostasis." 3. " soft science in China medicinal plants ": " suppressing the hyperactive liver improving eyesight.
Controlling stagnant blood crux, headache, cough with dyspnea, skin pruritus due to wind pathogen, sore throat, skin ulcer itches, toxic swelling."
Radix Isatidis: bitter；Cold.Return liver；Stomach warp.Function cures mainly: heat clearing away；Removing toxic substances；Removing heat from blood；Sore-throat relieving.Main maculae caused by violent heat pathogen；High hot head
Bitterly；Major part pestilence；Scarlet fever；Erysipelas；Mumps；Sore throat；Skin ulcer swells；Chickenpox；Measles；Hepatitis；Influenza.
Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Urinate for edema
Lacking, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Folium Violae Acuminatae: another name: red Herba violae patrinii, source: for the leaf of Violaceae plant drumsticks common violet.Xia Qiu gathers, and dries or fresh
With.Habitat branch: in being born in broad-leaf forest, border, the roadside in gully, shrubbery, meadow etc..Distribution Shaanxi and China are northern and eastern
Various places, north.Nature and flavor: light, cold.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control cough due to lung-heat, treating swelling and pain by traumatic injury, furuncle toxic swelling.
Apis room: another name: Apis nest, honey spleen, honey comb, source: medical material Ji Yuan: for Apidae animal apis cerana etc.
Nest.Habitat branch: China's most area all has cultivation.Taste is micro-sweet；Cool in nature.Function cures mainly: removing toxic substances and promoting subsidence of swelling；Wind dispelling insecticide.
Main sore and toxic；Pharyngalgia is coughed；Chronic rhinitis；Sinusitis；Eczema pruritus；Skin ulcer tinea.
Long pine: another name: climb ground pine；Medical material Ji Yuan: for the branch and leaf of pinaceae plant siberian dwarf pine.Latin plant animal mineral name:
Pinus pumila (Pall.) Regel [Pinus cembra L.var.pumila Pall.] gathers and stores: the four seasons can adopt,
Dry.Function cures mainly: preventing phlegm from forming and stopping coughing；Relieving asthma.Main cough due to chronic tracheitis；Asthma.
Semen Euryales: sweet, puckery is flat.Return spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping.For nocturnal emission
Spermatorrhea, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means
Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1
Embodiments provide a kind of ablactational baby pig feed additive, be made up of the raw material of following parts by weight:
Ganoderma 15 weight portion, Radix Salviae Miltiorrhizae 12 weight portion, Proceras venosata Walker 18 weight portion, Herba Tagetis Patulae 17 weight portion, bitter mustard 15 weight portion, Tricholoma mongolicum Imai 7 weight
Amount part, Caulis et Folium Chrysanthemi segeti 6 weight portion, Formica fusca 5 weight portion, Fructus Atriplicis Sibiricae 11 weight portion and Radix Isatidis 12 weight portion；
Its preparation method is:
The first step, will be mixed in proportion by other described raw medicinal material in addition to Caulis et Folium Chrysanthemi segeti, add relative to mixture quality 3 times
Determining alcohol is the ethanol of 90%, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained to add
Relative to the ethanol that determining alcohol is 90% of described medicinal residues quality 2 times, it is heated to reflux 2 hours, extracts, filter and obtain the second extraction
Liquid；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that
The micropowders of 350 mesh；
3rd step, after Caulis et Folium Chrysanthemi segeti is placed in dehydrator drying, then is ground into powder and obtains Caulis et Folium Chrysanthemi segeti powder；
4th step, by second step obtain micropowders and the 3rd step obtain Caulis et Folium Chrysanthemi segeti powder mixing, be subsequently adding relative to
Micropowders and the starch of Caulis et Folium Chrysanthemi segeti powder mixing quality 3 times, mixing, it is thus achieved that powder.
Using method: after first 7 days of pig transmissible encephalomyelitis vaccine of injection or injection sensitized vaccine, feedstuff is added
Agent is mixed in pig milk powder according to the ratio of 1:50, then according to conventional method feeds piglet once a day, is fed to vaccinate
The previous day.
Embodiment 2
Embodiments provide a kind of ablactational baby pig feed additive, be made up of the raw material of following parts by weight:
Ganoderma 15 weight portion, Radix Salviae Miltiorrhizae 12 weight portion, Proceras venosata Walker 18 weight portion, Herba Tagetis Patulae 17 weight portion, bitter mustard 15 weight portion, Tricholoma mongolicum Imai 7 weight
Measure part, Caulis et Folium Chrysanthemi segeti 6 weight portion, Formica fusca 5 weight portion, Fructus Atriplicis Sibiricae 11 weight portion, Radix Isatidis 12 weight portion, Poria 12 weight portion, walk limit
Boundary 11 weight portion, Apis room 5 weight portion, long loose 7 weight portions and Semen Euryales 14 weight portion；
Its preparation method is:
The first step, will be mixed in proportion by other described raw medicinal material in addition to Caulis et Folium Chrysanthemi segeti, add relative to mixture quality 2 times
Determining alcohol is the ethanol of 90%, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained to add
Relative to the ethanol that determining alcohol is 90% of described medicinal residues quality 2 times, it is heated to reflux 2 hours, extracts, filter and obtain the second extraction
Liquid；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 2 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that
The micropowders of 400 mesh；
3rd step, after Caulis et Folium Chrysanthemi segeti is placed in dehydrator drying, then is ground into powder and obtains Caulis et Folium Chrysanthemi segeti powder；
4th step, by second step obtain micropowders and the 3rd step obtain Caulis et Folium Chrysanthemi segeti powder mixing, be subsequently adding relative to
Micropowders and the starch of Caulis et Folium Chrysanthemi segeti powder mixing quality 3 times, mixing, it is thus achieved that powder.
Using method: after first 7 days of pig transmissible encephalomyelitis vaccine of injection or injection sensitized vaccine, feedstuff is added
Agent is mixed in pig milk powder according to the ratio of 1:50, then according to conventional method feeds piglet once a day, is fed to vaccinate
The previous day.
Toxicity test
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity
Test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；By the reality of the present invention
The feed additive executing example 1 preparation is dissolved in water, and (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is
5ml/kg (i.e. unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, between administration
6 hours intervals, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: with
Matched group compares, and after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body
Heavily increase the most normal.Therefore, the feed additive acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: the feed additive of the embodiment of the present invention 2 is raw by 6.43,15.72 and 36.41g to mice
After medicine/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks, result shows: feedstuff of the present invention adds
Agent to indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all without bright
Development rings, and internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, and mice
Each internal organs are all without substantially changing.Illustrate that feed additive of the present invention is little to toxicity after mice long-term prescription, the most different after drug withdrawal
Sample reacts, application safety.
Contrast test
Selecting the healthy ablactational baby pig 500 about 3 monthly ages to be only used as experimental subject, piglet is all healthy without any disease after testing
Disease, by 500 piglets and sow isolated rearing, is randomly divided into piglet five experimental grouies, often group 100 at random, is respectively real
Executing example group 1, embodiment group 2, matched group and blank group (include two experimental grouies, totally 200), each group all uses pig milk
Powder feeds.Embodiment group 1 and embodiment group 2 piglet feed once a day and are added with the embodiment of the present invention 1 and present invention reality
The milk powder executing example 2 feed additive feeds, and after continuous 7 days, the piglet of embodiment group 1, embodiment group 2 and matched group is equal
Carry out injecting the attenuated live vaccines of pig transmissible encephalomyelitis virus, then proceed to feed each group of piglet, note according to pig milk powder
Observe after penetrating vaccine 1-4 month, then embodiment group 1, embodiment group 2, matched group and blank group are carried out artificial viral
Inoculation, then observe each group of piglet whether occur body temperature height, anorexia, asthenia, vomit, the symptom such as diarrhoea, and examined by serum
Test whether make a definite diagnosis be pig transmissible encephalomyelitis, statistics morbidity number, result is as shown in table 1, and morbidity piglet is carried out in time every
From.
Table 1 each experimental group piglet sickness rate matched group
| Group | Sum | Morbidity number | Sickness rate | Protective rate |
| Embodiment group 1 | 100 | 13 | 13% | 87% |
| Embodiment group 2 | 100 | 8 | 8% | 92% |
| Matched group | 100 | 28 | 28% | 72% |
| Blank group | 200 | 199 | 99.5% | - |
From the data of table 1, and only use compared with attenuated live vaccines carries out prevention, in conjunction with attenuated live vaccines and embodiment
It is more excellent that the additive of group 1 or embodiment group 2 carries out preventive effect, and protective rate exceeds 15% and 20%.
199 piglets of morbidity in blank group are isolated, chooses 150 piglets and carry out Experiment on therapy, by 150
Piglet is randomly divided into three groups, often group 50, and respectively embodiment group 1, embodiment group 2 and matched group, three groups of piglets are all injected
Rehabilitation porcine blood serum (its antibody is consistent with the viral species of artificial vaccination) is treated, wherein, and embodiment group 1 and embodiment group 2
Feed the pig milk powder adding the feed additive of Example 1 and Example 2 of the present invention the most respectively every day 2 times, according to above-mentioned side
Formula feeds 1 month, and therapeutic effect is as shown in table 2.Wherein, recovery from illness refers to that piglet, through the observation of 1-3 month, finds piglet
Wholly or substantially recover normal；Observe 3 months and recover normal even death yet and be defined as " dead ".
Table 2 each experimental group therapeutic outcome synopsis
| Group | Sum | Recovery from illness | Dead | Cure rate |
| Embodiment group 1 | 50 | 45 | 5 | 90% |
| Embodiment group 2 | 50 | 49 | 1 | 98% |
| Matched group | 50 | 39 | 11 | 78% |
Knowable to the data of table 2, the feed additive of serum and the embodiment of the present invention 1 or embodiment 2 is used to treat,
Effect is significantly better than being used alone serotherapeutical matched group, and the feed additive of the present invention has safety pair high, nontoxic
The advantage of effect.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (7)
1. an ablactational baby pig feed additive, it is characterised in that described feed additive includes following raw medicinal material: spirit
Sesame, Radix Salviae Miltiorrhizae, Proceras venosata Walker, Herba Tagetis Patulae, bitter mustard, Tricholoma mongolicum Imai, Caulis et Folium Chrysanthemi segeti, Formica fusca, Fructus Atriplicis Sibiricae and Radix Isatidis.
Feed additive the most according to claim 1, it is characterised in that described feed additive is by following parts by weight
Raw material is made: Ganoderma 10-20 weight portion, Radix Salviae Miltiorrhizae 10-15 weight portion, Proceras venosata Walker 12-25 weight portion, Herba Tagetis Patulae 14-21 weight portion,
Bitter mustard 10-20 weight portion, Tricholoma mongolicum Imai 5-10 weight portion, Caulis et Folium Chrysanthemi segeti 3-9 weight portion, Formica fusca 3-7 weight portion, Fructus Atriplicis Sibiricae 8-15 weight portion and
Radix Isatidis 10-20 weight portion.
Feed additive the most according to claim 1 and 2, it is characterised in that described feed additive is by following weight portion
The raw material of number is made: Ganoderma 15 weight portion, Radix Salviae Miltiorrhizae 12 weight portion, Proceras venosata Walker 18 weight portion, Herba Tagetis Patulae 17 weight portion, bitter mustard 15 weight
Amount part, Tricholoma mongolicum Imai 7 weight portion, Caulis et Folium Chrysanthemi segeti 6 weight portion, Formica fusca 5 weight portion, Fructus Atriplicis Sibiricae 11 weight portion and Radix Isatidis 12 weight portion.
4. according to the feed additive described in any one of claim 1-3, it is characterised in that described feed additive also includes:
Poria, Folium Violae Acuminatae, Apis room, long pine and Semen Euryales.
5. according to the feed additive described in any one of claim 1-4, it is characterised in that described feed additive is by following heavy
The raw material of amount number is made: Ganoderma 10-20 weight portion, Radix Salviae Miltiorrhizae 10-15 weight portion, Proceras venosata Walker 12-25 weight portion, Herba Tagetis Patulae 14-
21 weight portions, bitter mustard 10-20 weight portion, Tricholoma mongolicum Imai 5-10 weight portion, Caulis et Folium Chrysanthemi segeti 3-9 weight portion, Formica fusca 3-7 weight portion, Fructus Atriplicis Sibiricae 8-
15 weight portions, Radix Isatidis 10-20 weight portion, Poria 10-15 weight portion, Folium Violae Acuminatae 6-15 weight portion, Apis room 4-6 weight portion,
Long pine 5-10 weight portion and Semen Euryales 12-16 weight portion.
6. according to the feed additive described in any one of claim 1-5, it is characterised in that described feed additive is by following heavy
The raw material of amount number is made: Ganoderma 15 weight portion, Radix Salviae Miltiorrhizae 12 weight portion, Proceras venosata Walker 18 weight portion, Herba Tagetis Patulae 17 weight portion, bitter mustard
15 weight portions, Tricholoma mongolicum Imai 7 weight portion, Caulis et Folium Chrysanthemi segeti 6 weight portion, Formica fusca 5 weight portion, Fructus Atriplicis Sibiricae 11 weight portion, Radix Isatidis 12 weight portion, Fu
Siberian cocklebur 12 weight portion, Folium Violae Acuminatae 11 weight portion, Apis room 5 weight portion, long loose 7 weight portions and Semen Euryales 14 weight portion.
7. according to the feed additive described in any one of claim 1-6, it is characterised in that the preparation side of described feed additive
Method is:
The first step, will be mixed in proportion by other described raw medicinal material in addition to Caulis et Folium Chrysanthemi segeti, add relative to mixture quality 2～4 times
Determining alcohol is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained
Add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract,
Filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, obtains
Get dry extract；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 300
Mesh～the micropowders of 400 mesh；
3rd step, after Caulis et Folium Chrysanthemi segeti is placed in dehydrator drying, then is ground into powder and obtains Caulis et Folium Chrysanthemi segeti powder；
4th step, the Caulis et Folium Chrysanthemi segeti powder mixing that the micropowders obtained by second step and the 3rd step obtain, it is subsequently adding relative to ultra micro
Fine powder and Caulis et Folium Chrysanthemi segeti powder mixing quality 2～the starch of 4 times, mixing, it is thus achieved that powder.
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| Application Number | Priority Date | Filing Date | Title |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619993A (en) * | 2017-03-06 | 2017-05-10 | 长沙瑞多康生物科技有限公司 | Composition for preventing swine infectious encephalomyelitis |
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|---|---|---|---|---|
| CN101406243A (en) * | 2007-10-11 | 2009-04-15 | 李浚东 | Method for breeding chickens by using environment-friendly feedstuff of breeding chickens |
| CN103652490A (en) * | 2013-12-13 | 2014-03-26 | 山东新希望六和集团有限公司 | Pig feed for treating blue-eared pig disease and preparation method thereof |
| CN104982751A (en) * | 2015-08-06 | 2015-10-21 | 山东新希望六和集团有限公司 | Rice bran type piglet mixed feed and preparation method thereof |
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2016
- 2016-08-02 CN CN201610628942.3A patent/CN106173409A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406243A (en) * | 2007-10-11 | 2009-04-15 | 李浚东 | Method for breeding chickens by using environment-friendly feedstuff of breeding chickens |
| CN103652490A (en) * | 2013-12-13 | 2014-03-26 | 山东新希望六和集团有限公司 | Pig feed for treating blue-eared pig disease and preparation method thereof |
| CN104982751A (en) * | 2015-08-06 | 2015-10-21 | 山东新希望六和集团有限公司 | Rice bran type piglet mixed feed and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619993A (en) * | 2017-03-06 | 2017-05-10 | 长沙瑞多康生物科技有限公司 | Composition for preventing swine infectious encephalomyelitis |
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