CN103505593B - Chinese medicinal herb formula for removing necrotic tissue and promoting tissue regeneration - Google Patents

Abstract

The invention provides a Chinese medicinal herb preparation for removing necrotic tissue and promoting tissue regeneration, aiming at the disadvantages that destructive means such as amputation is needed for generally treating patients suffering from seriously infected injury, the expense is relatively high and scars are left at an affected part. The invention has a technical scheme that the Chinese medicinal herb preparation for removing necrotic tissue and promoting tissue regeneration is prepared from 8-12g of Chinese angelica, 10-14g of wrinkled gianthyssop herb, 8-12g of pawpaw, 8-12g of pericarpium arecae, 10-14g of chrysanthemum, 8-12g of dried orange peel, 10-14g of glossy privet fruit, 8-12g of cassia twig, 8-12g of caulis spatholobi, 8-12g of scutellaria baicalensis, 8-12g of hawthorn, 10-14g of schizonepeta, 8-12g of burdock, 8-12g of teasel root, 10-14g of sophora fruit and 7-11g of liquorice. The medicines with the above ratio are boiled and extractive is extracted or the medicines are smashed into powder. With the adoption of the Chinese medicinal herb preparation, good effects of removing necrotic tissue and promoting tissue regeneration are achieved, no destructive amputation is needed, no scars are left at the wounded part, expense of the patients is saved greatly, and the economic burden is reduced.

Description

A kind of Chinese herbal and crude drugs preparations of removing the necrotic tissue and promoting granulation

Technical field

The present invention relates to medical domain, especially a kind of Chinese herbal and crude drugs preparations of removing the necrotic tissue and promoting granulation.

Background technology

Now the patient of some wound severe infections for the treatment of, in order to ensure the life of patient, its main Therapeutic Method is excised at the position of severe infections, causes larger misery to patient.And also can, at affected part scar, spend higher after usually fully recovering simultaneously, bring heavy psychology and physiological misery to patient and family members, the life later to it causes inconvenience.

Summary of the invention

for the destructive means such as client need amputation of general treatment wound severe infections, costly and in the deficiency of affected part scar, the invention provides the technical scheme of dealing with problems is: consist of according to weight proportion: Radix Angelicae Sinensis 8 ~ 12g; Herba Pogostemonis 10 ~ 14g; Fructus Chaenomelis 8 ~ 12g; Pericarpium Arecae 8 ~ 12g; Flos Chrysanthemi 10 ~ 14g; Pericarpium Citri Reticulatae 8 ~ 12g; Fructus Ligustri Lucidi 10 ~ 14g; Ramulus Cinnamomi 8 ~ 12g; Caulis Spatholobi 8 ~ 12g; Radix Scutellariae 8 ~ 12g; Fructus Crataegi 8 ~ 12g; Herba Schizonepetae 10 ~ 14g; Fructus Arctii 8 ~ 12g; Radix Dipsaci 8 ~ 12g; Fructus Sophorae 10 ~ 14g; Radix Glycyrrhizae 7 ~ 11g; The medicine of said ratio is carried out decoct and extract it and decoct juice or powder is made in pulverizing.

The optimum weight proportioning of the Chinese herbal and crude drugs preparations of a kind of removing the necrotic tissue and promoting granulation provided by the invention consists of: Radix Angelicae Sinensis 10g; Herba Pogostemonis 12g; Fructus Chaenomelis 10g; Pericarpium Arecae 10g; Flos Chrysanthemi 12g; Pericarpium Citri Reticulatae 10g; Fructus Ligustri Lucidi 12g; Ramulus Cinnamomi 10g; Caulis Spatholobi 10g; Radix Scutellariae 10g; Fructus Crataegi 10g; Herba Schizonepetae 12g; Fructus Arctii 10g; Radix Dipsaci 10g; Fructus Sophorae 12g; Radix Glycyrrhizae 9g.

The invention has the beneficial effects as follows: not only removing the necrotic tissue and promoting granulation is effective, and patient is without the need to destructive amputation, and affected part does not fall cicatrix, saves the expense of sufferer greatly, reduces financial burden.

Radix Angelicae Sinensis: anti-hypoxia, conditioner body immunity function, there is anticancer, cosmetology effect, enrich blood invigorate blood circulation, antibacterial, arteriosclerosis.

Pharmacological action: 1) anticoagulant effect.

2) Radix Angelicae Sinensis has extremely significant hematosis.

3) antiinflammatory action: reduce capillary permeability; Suppress synthesis or the release of PGE2.

4) antibacterial action: Radix Angelicae Sinensis all has antibacterial action to external dysentery, typhoid fever, paratyphoid fever, escherichia coli, diphtheria corynebacterium, vibrio cholera and a, B Hemolytic streptococcus etc.These product can reduce mice capillary permeability.External can accelerate rabbit ear wound healing, contrafluxion, leukocyte and fiber is infiltrated, newborn epithelium regeneration, has hemostasis and strengthen peripheral circulation effect to local organization.Illustrate that Radix Angelicae Sinensis has antibacterial, antiinflammation.Radix Angelicae Sinensis hot water extract has obvious inhibitory action to chronic rheumatoid sexually transmitted disease (STD) experimental animal model when its adjuvant arthritis acute attack.

Herba Pogostemonis: dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach; Hands, tinea pedis.

Pharmacological action: 1) antifungic action: Herba Pogostemonis decoct (8% ~ 15%) has inhibitory action to multiple pathogenic funguses such as trichophyton in vitro.

2) anti-leptospira effect: agastache rugosa water decoct has inhibitory action when concentration is 15mg/ml to leptospira; Killing action is had to leptospira when concentration increases to 31mg/ml.

3) antivirus action: the Flavonoid substances in Herba Pogostemonis has antivirus action.

Fructus Chaenomelis: dehumidify sharp numbness, emergency relaxing muscles and tendons.

Pharmacological action: 1) hepatoprotective effect.2) antibacterial action.

Pericarpium Arecae: therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, breast abdominal distention is vexed, defecates not well, edema, beriberi, dysuria.

Pharmacological action: rabbits infestines tonicity can be made to raise to the effect Pericarpium Arecae decoct of intestinal smooth muscle, shrinkage amplitude reduces, and its effect can by atropine institute antagonism.

Flos Chrysanthemi: dispelling wind, heat clearing away, improving eyesight ,effect of removing toxic substances.

Pharmacological action: antiinflammatory action was as far back as 1950, and Flos Chrysanthemi extract can affect the permeability of mice blood capillary, increases capillary resistance, thus has antiinflammatory action to have researcher just to find.

Pericarpium Citri Reticulatae: appetizing drying dampness to eliminate phlegm of regulating the flow of vital energy controls the spleen-stomach disease.

Pharmacological action: antiinflammatory, antiulcer, choleretic effect hesperidin can not alleviate rat hindlimb claw because of formaldehyde-caused edema, and in citrus plant, cis coumarin then has antiinflammatory action.The permeability (rabbit chloroform method and white mice snake venom method) of methylhesperidin (mixture based on flavanone type) to capillary tube also has inhibitory action, and can prevent snake venom from causing hemorrhage, toxicity is minimum.The rat ulcer that methylhesperidin causes ligation pylorus, has obvious antiulcer action, share can strengthen its effect with vitamin C and K, oral then invalid, to rat lumbar injection, shows choleretic effect rapidly, and vitamin C and K also can strengthen this effect.

Fructus Arctii: dispelling wind and heat pathogens; Heat-clearing and toxic substances removing rash.

Pharmacological action: 1) antibiosis and antiviral functions: Fructus Arctii infusion (1:2) has bacteriostasis to 9 kinds of pathogenic funguses such as cocoon color hair tinea mattress, proper alignment hair tinea mattress, perhaps blue achorion, Du's big belly microspore tinea bacterium difficult to understand, Pilus Caprae seu Ovis sample microspore tinea mattress, epidermophyton inguinale, epidermophyton rubrum, star-shaped nocardia, rust microspore tinea bacterium in vitro.Fructus Arctii extract's tool AIDS virus resisting (HIV) is active to have data to show.

2) Arctiin has dilating effect to frog lower limb and rabbit ear blood vessel, and of short duration reduces blood pressure, and all has suppression or paralysis effect to isolated rabbit uterus, intestinal tube, nervus motorius and bone network flesh.There are mild diuretic, discharge function.

Fructus Ligustri Lucidi: liver and kidney tonifying; Clearind deficient heat.

Pharmacological action: 1) on the impact of body's immunity: raise peripheral leukocytes Fructus Ligustri Lucidi and can significantly raise peripheral leukocytes number, its effective ingredient is oleanolic acid.Alcohol extract can go up cyclophosphamide (cy) induced mice leukopenia.

2) affecting Fructus Ligustri Lucidi and can significantly improve T lymphocyte function on cellular immune function.

3) Fructus Ligustri Lucidi has the effect strengthening humoral immune function.

Ramulus Cinnamomi: expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.

Pharmacological action: 1) to the effect of central nervous system: sedation, analgesic activity, refrigeration function, anticonvulsant action.

2) antibacterial action: Ramulus Cinnamomi decoct also has comparatively high inhibition effect to Common Pathogenic dermatophytes.

3) antiinflammatory action and on immune impact: adopt orthogonal design to find guizhi decoction prescription analysis, on suppression inflammatory swelling, causes scorching latter 1 hour, in the single medicinal material of guizhi decoction, the strongest with the effect of Ramulus Cinnamomi.

Caulis Spatholobi: enrich blood, invigorates blood circulation, dredging collateral.

Pharmacological action: 1) vasodilative effect: Caulis Spatholobi Aqueous extracts precipitate with ethanol preparation 20mg/kg directly injects femoral artery, injecting femoral artery blood flow in latter 10 minutes increases by 42.7%; During peak value, value added reaches 133%; Vascular resistance reduces 45.3%.

2) antiplatelet aggregative activity: Caulis Spatholobi crude drug water decoction-alcohol sedimentation preparation, when 100mg/kg concentration, has obvious inhibitory action to the rat platelet aggregation of two phosphorus adenosine inductions in vitro.

Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, blood pressure lowering.

Pharmacological action: 1) antibacterial, antiviral.

2) antiinflammatory: baicalin, baicalin can suppress acute inflammatory reaction.Inflammation-inhibiting model oozes out swelling, capillary permeability increases; Suppress rat assist agent arthritis.

Fructus Crataegi: can help digestion long-pending, spleen reinforcing.

Herba Schizonepetae: dispel the wind; Induce sweat; Rash; Hemostasis.

Pharmacological action: 1) antibacterial and antiinflammatory action: experiment in vitro proves: Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.In addition, certain inhibitory action is had to anthrax bacillus, group B streptococcus, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus and Bacillus tuberculosis etc.Herba Schizonepetae decoct and Herba Schizonepetae mix decoct all to be had obviously suppress mice auricle swelling effect with Radix Saposhnikoviae, and mixing decoct is more effective than singly decocting.The inflammation that Herba Schizonepetae Dichlorodiphenyl Acetate causes has obvious antiinflammatory action.

2) antipyretic effect: Herba Schizonepetae decoct has antipyretic effect, makes fever in rabbits with typhoid fever polyvalent vaccine, gives Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, finds that there is faint refrigeration function.The analgesic activity of Herba Schizonepetae is with d-menthone for representative, and with d-menthone 100mg/kg to mouse stomach, can suppress the writhing response because lumbar injection acetic acid causes, its intensity is suitable with aminophenazone.

3) anastalsis: raw product Herba Schizonepetae obviously can not shorten the bleeding time, and Herba Schizonepetae charcoal then makes hemorrhage time shorten 72.6%; Raw product Herba Schizonepetae makes reduced clotting time 30%, and Herba Schizonepetae charcoal shortens 77.7%, and namely Herba Schizonepetae has anastalsis after parch to black.Have report to point out, Herba Schizonepetae charcoal suspension and Herba Schizonepetae charcoal volatile oil Emulsion all have obvious anastalsis, and relevant to dosage.But Herba Schizonepetae charcoal water decoction and the Herba Schizonepetae charcoal water decoction after proposing volatile oil, be showed no obvious anastalsis.Reporter thinks, when using Herba Schizonepetae charcoal to treat various hemorrhagic disease clinically, should take orally as good with powder.

Radix Dipsaci: invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.

Pharmacological action: 1) vitamin antagonist E deficiency disease: through white mice and chicken test, prove that Radix Dipsaci has the effect of vitamin antagonist E deficiency disease.

2) hemostasis, analgesic activity: effect carbuncle and ulcer being had to evacuation of pus, hemostasis, analgesia, promotion tissue regeneration.

Fructus Sophorae: bitter in the mouth, cold in nature, return liver, large intestine channel, function clearing away heat-fire, cooling blood for hemostasis.

Pharmacological action: Fructus Sophorae, Flos Sophorae are the blood-cooling hemostatic that the traditional Chinese medical science is commonly used, is clinically used for haematemesis, epistaxis, has blood in stool, bleeding hemorrhoids, hematuria, metrorrhagia etc. belong to the hemorrhage of heat syndrome.Modern age pharmacological research, Fructus Sophorae, Flos Sophorae have blood pressure lowering and improve the effect of capillary fragility.

Radix Glycyrrhizae: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.

Detailed description of the invention

Instantiation 1: get Radix Angelicae Sinensis 9g; Herba Pogostemonis 11g; Fructus Chaenomelis 9g; Pericarpium Arecae 9g; Flos Chrysanthemi 11g; Pericarpium Citri Reticulatae 9g; Fructus Ligustri Lucidi 11g; Ramulus Cinnamomi 9g; Caulis Spatholobi 9g; Radix Scutellariae 9g; Fructus Crataegi 9g; Herba Schizonepetae 11g; Fructus Arctii 9g; Radix Dipsaci 9g; Fructus Sophorae 11g; Radix Glycyrrhizae 8g; Soak large after 10 ~ 15 minutes baked wheaten cake to medicine juice boiling, then slow fire boils 3 ~ 4 minutes, takes out decoction and takes orally.

And, the pulverizing medicinal materials of above equal quality can be made external pulvis, coordinate for oral administration.

Two weeks is a course for the treatment of, and 2 courses for the treatment of were almost recovered, and preventing from scar.

Instantiation 2: get Radix Angelicae Sinensis 10g; Herba Pogostemonis 12g; Fructus Chaenomelis 10g; Pericarpium Arecae 10g; Flos Chrysanthemi 12g; Pericarpium Citri Reticulatae 10g; Fructus Ligustri Lucidi 12g; Ramulus Cinnamomi 10g; Caulis Spatholobi 10g; Radix Scutellariae 10g; Fructus Crataegi 10g; Herba Schizonepetae 12g; Fructus Arctii 10g; Radix Dipsaci 10g; Fructus Sophorae 12g; Radix Glycyrrhizae 9g; Soak large after 15 ~ 20 minutes baked wheaten cake to medicine juice boiling, then slow fire boils 4 ~ 5 minutes, takes out medicine juice and takes orally.

And, the pulverizing medicinal materials of above equal quality can be made external pulvis, coordinate for oral administration.

Two weeks is a course for the treatment of, and 2 courses for the treatment of were almost recovered, and preventing from scar.

The present invention treats case 1: Liu so-and-so, people from Luoyang, Henan Province, 40 years old.Diagnose the right lower limb comminuted fracture after its traffic accident, in sinus tract, pus and blood is more than, prepares amputation.Seek medical advice in May, 2011, the preparation adopting the present invention to mention and compounding method, adopt the form of interior external application, after two courses for the treatment of, and transference cure, cost only over thousands of unit.

The present invention treats case 2: Zhao so-and-so, Luoyang, henan people, 48 years old.Because of malpractice after left lower limb comminuted fracture, from steel plate paint eye, continuously outflow pus, multi-treatment is invalid, prepares amputation.Use the preparation mentioned in the present invention and compounding method after medical, adopt the form of interior external application, transference cure after 3 courses for the treatment of, cost only 2,000 yuan.

Note and taboo: avoid pungent food, seafood and other liability stimulate food, are cautious use of Oleum Sesami allergy sufferers.

Infectious pernicious disunion wound, innominate toxic swelling the present invention generally can cure according to grade and moderate infection treatment the course for the treatment of.

Diabetics, antibiotic antibody antigen allergy and body constitution weak person, this class patient is more careful to antibiotic usage again, general wound is extremely difficult to healing, and medicine of the present invention generally has unique effect, according to patient's wound area and degree of depth SM thereof to this kind of patient.

Touch water, for the tactile water that wound is abstained from.

Claims (2)

1. a Chinese herbal and crude drugs preparations for removing the necrotic tissue and promoting granulation, is characterized in that: consist of according to weight proportion: Radix Angelicae Sinensis 8 ~ 12g; Herba Pogostemonis 10 ~ 14g; Fructus Chaenomelis 8 ~ 12g; Pericarpium Arecae 8 ~ 12g; Flos Chrysanthemi 10 ~ 14g; Pericarpium Citri Reticulatae 8 ~ 12g; Fructus Ligustri Lucidi 10 ~ 14g; Ramulus Cinnamomi 8 ~ 12g; Caulis Spatholobi 8 ~ 12g; Radix Scutellariae 8 ~ 12g; Fructus Crataegi 8 ~ 12g; Herba Schizonepetae 10 ~ 14g; Fructus Arctii 8 ~ 12g; Radix Dipsaci 8 ~ 12g; Fructus Sophorae 10 ~ 14g; Radix Glycyrrhizae 7 ~ 11g; The medicine of said ratio is carried out decoct and extract it and decoct juice or powder is made in pulverizing.

2. the Chinese herbal and crude drugs preparations of a kind of removing the necrotic tissue and promoting granulation according to claim 1, is characterized in that: optimum weight proportioning consists of: Radix Angelicae Sinensis 10g; Herba Pogostemonis 12g; Fructus Chaenomelis 10g; Pericarpium Arecae 10g; Flos Chrysanthemi 12g; Pericarpium Citri Reticulatae 10g; Fructus Ligustri Lucidi 12g; Ramulus Cinnamomi 10g; Caulis Spatholobi 10g; Radix Scutellariae 10g; Fructus Crataegi 10g; Herba Schizonepetae 12g; Fructus Arctii 10g; Radix Dipsaci 10g; Fructus Sophorae 12g; Radix Glycyrrhizae 9g.