CN103432215A - Medicine used for preventing and treating high swine fever and preparation method thereof - Google Patents
Medicine used for preventing and treating high swine fever and preparation method thereof Download PDFInfo
- Publication number
- CN103432215A CN103432215A CN201310318565XA CN201310318565A CN103432215A CN 103432215 A CN103432215 A CN 103432215A CN 201310318565X A CN201310318565X A CN 201310318565XA CN 201310318565 A CN201310318565 A CN 201310318565A CN 103432215 A CN103432215 A CN 103432215A
- Authority
- CN
- China
- Prior art keywords
- medicine
- radix
- parts
- preventing
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 87
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 229940079593 drug Drugs 0.000 title claims description 20
- 206010037660 Pyrexia Diseases 0.000 title abstract 3
- 241000282898 Sus scrofa Species 0.000 title abstract 3
- 239000008187 granular material Substances 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 239000002775 capsule Substances 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 239000003826 tablet Substances 0.000 claims abstract description 4
- 206010020843 Hyperthermia Diseases 0.000 claims description 48
- 230000036031 hyperthermia Effects 0.000 claims description 48
- 239000000706 filtrate Substances 0.000 claims description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 241000628997 Flos Species 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000010992 reflux Methods 0.000 claims description 10
- 229920001353 Dextrin Polymers 0.000 claims description 9
- 239000004375 Dextrin Substances 0.000 claims description 9
- 235000019425 dextrin Nutrition 0.000 claims description 9
- -1 hydroxypropyl Chemical group 0.000 claims description 9
- 241000245240 Lonicera Species 0.000 claims description 8
- 241000207929 Scutellaria Species 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 239000002671 adjuvant Substances 0.000 claims description 7
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000004302 potassium sorbate Substances 0.000 claims description 5
- 229940069338 potassium sorbate Drugs 0.000 claims description 5
- 235000010241 potassium sorbate Nutrition 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 13
- 206010059866 Drug resistance Diseases 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000004615 ingredient Substances 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 244000167230 Lonicera japonica Species 0.000 abstract 1
- 235000017617 Lonicera japonica Nutrition 0.000 abstract 1
- 244000235756 Microcos paniculata Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 23
- 231100000614 poison Toxicity 0.000 description 8
- 239000003440 toxic substance Substances 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000012467 final product Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 208000003322 Coinfection Diseases 0.000 description 3
- 208000015220 Febrile disease Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010014080 Ecchymosis Diseases 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000007779 soft material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine used for preventing and treating high swine fever. The medicine comprises following ingredients, by weight: 30 to 110 portions of folium isatidis, 40 to 140 portions of lonicera japonica, 20 to 120 portions of rheum officinale, 10 to 100 portions of balloonflower root, 20 to 75 portion of microcos paniculata and 20 to 90 portions of root of scutellaria baicalensis. The medicine is mixed with pharmaceutical acceptable accessories, and the mixture can be used for production of powder, granule, capsule, tablet and oral liquid. The dialectical treatment principle of traditional Chinese medicine prescription is reflected by the medicine. Characteristics of the medicine are that: curative effect is excellent and fast; no drug resistance is caused; the medicine is capable of clearing heat and detoxifying, and resisting bacteria and removing inflammation, and is friendly to the environment; and no residue is left. The medicine is used for preventing and treating high swine fever. The preparation method is simple; cost is low; market competitiveness is relatively high; the raw materials are abundant, and are affordable; the medicine is suitable for industrialized production and application.
Description
Technical field
The present invention relates to field of veterinary, relate in particular to a kind of medicine of preventing and treating porcine hyperthermia, the invention still further relates to the preparation method of this medicine.
Background technology
Porcine hyperthermia be the immune system (spleen, thymus, lymph, tonsil etc.) due to pig suppressed after, lose normal immunologic function, infect the infectious disease of acute, hot, the highly pathogenic and high lethal that the multiple pathogens mixing such as other viruses such as reproductive and respiratory syndrome virus and antibacterial, parasite or secondary infection cause, therefore more difficult control clinically, therapeutic effect is often not ideal enough.This evil of being critically ill is serious, its propagating area, and the epidemic situation epidemic regions is wide, and all there is the pig farm morbidity in a plurality of provinces and cities such as south China, East China, Central China, North China, northeast, southwest.The epidemic situation spread speed is fast, and swinery falls ill stage by stage, in same pig farm usually in large pig or sow first fall ill, within 2 ~ 5 days, involve full group, diffuse to whole pig farm about 10 days.Epidemic situation all can occur each season, did not occur over just the summer that temperature is higher, and spring, autumn, winter also can occur.Porcine hyperthermia has the characteristics such as spread speed is fast, sickness rate is high, mortality rate is high, cure rate is low, causes the pig mortality, and spreads gradually and spread, and to pig industry, brings huge economic loss, and animal and veterinary bound pair epidemic situation is shown great attention to both at home and abroad.
The porcine hyperthermia medication, should reduce as far as possible pig stress, take as much as possible oral medication, reduce the number of times of injectable drug.The medicine for the treatment of porcine hyperthermia mainly contains antibiotic and the antipyretic such as amoxicillin, taimulin.The shortcoming of said medicine is:
(1) use antibiotic easily to cause drug resistance and secondary infection, and easily cause the pork product veterinary drug residue to exceed standard, left drug enters food chain, causes just antibacterial to produce a major reason of drug resistance.
(2) the large bolus injection antibiotic can strengthen the case fatality rate of pig repeatedly, heavy dose of Reusability antipyretic can increase case fatality rate (list of references: Shi Chunyan. the treatment measure [J] of porcine hyperthermia. the animal and veterinary scientific and technological information, 2011,12:74-75).
(3) pathogen of porcine hyperthermia has antibacterial, virus etc., belongs to mixed infection, and single Western medicine is difficult to control the state of an illness.
Summary of the invention
The object of the invention is to propose a kind of medicine of preventing and treating porcine hyperthermia, this kind of medicine is Chinese medicinal formulae, and the characteristics such as it has good effect, instant effect, has no drug resistance, heat-clearing and toxic substances removing and anti-inflammation, for prevention and treatment porcine hyperthermia.
In order to solve the prior art problem, the present invention is achieved by the following technical solutions.
A kind of medicine of preventing and treating porcine hyperthermia, be comprised of with 20 ~ 90 parts of Radix Scutellariaes 20 ~ 75 parts of 10 ~ 100 parts of 20 ~ 120 parts of 40 ~ 140 parts of 30 ~ 110 parts of Folium Isatidiss, Flos Loniceraes, Radix Et Rhizoma Rhei, the Radix Platycodoniss, the Folium Microcoris paniculataes that measure by weight.
The medicine that the present invention prevents and treats porcine hyperthermia can mix with pharmaceutically acceptable adjuvant, is prepared into powder, granule, tablet, capsule or oral liquid.
Described adjuvant is one or both combinations in starch, dextrin, Icing Sugar, hydroxypropyl emthylcellulose and potassium sorbate.
Another object of the present invention is to propose a kind of preparation method of preventing and treating the medicine of porcine hyperthermia, and its step is as follows:
(1) take each raw material by above-mentioned formula ratio, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3) learn from else's experience Radix Platycodonis afterwards of step (1) adding in ethanol, adopt the reflux, extract, instrument to extract 4 times, and each time of extracting is 1.5h, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.28 ~ 1.32, obtain preventing and treating the medicine of porcine hyperthermia.
Described in step (3), the volume fraction of ethanol is 70%, the addition of ethanol is Radix Platycodonis 4 times.
Compared with prior art, beneficial effect of the present invention is as follows:
(1) the dialectical principle treated of medicine of the present invention performance Chinese medicinal formulae, the characteristics such as it has good effect, instant effect, has no drug resistance, heat-clearing and toxic substances removing, anti-inflammation, environmental protection and noresidue, for prevention and treatment porcine hyperthermia.
(2) pharmaceutical preparation of the present invention is simple, with low cost, has the stronger market competitiveness.
(3) source of medicine material of the present invention is abundant, and moderate cost is applicable to suitability for industrialized production and application.
The specific embodiment
The present invention has disclosed a kind of medicine of preventing and treating porcine hyperthermia, 20 ~ 75 parts of 10 ~ 100 parts of 20 ~ 120 parts of 40 ~ 140 parts of 30 ~ 110 parts of Folium Isatidiss, Flos Loniceraes, Radix Et Rhizoma Rhei, the Radix Platycodoniss, the Folium Microcoris paniculataes that measure by weight, with 20 ~ 90 parts of Radix Scutellariaes, consists of.
The medicine that the present invention prevents and treats porcine hyperthermia can mix with pharmaceutically acceptable adjuvant, is prepared into powder, granule, tablet, capsule or oral liquid.
Described adjuvant is one or several combinations in starch, dextrin, Icing Sugar, hydroxypropyl emthylcellulose and potassium sorbate.
The present invention selects the effect of Chinese medicine to be described below:
Folium Isatidis: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, dissipating blood stasis hemostasis.Swollen for epidemic febrile disease heating, a speckle dermexanthesis, anemopyretic cold, laryngopharynx swelling and pain, pneumonia, parotitis, epidemic cerebrospinal meningitis, encephalitis B, erysipelas and pain.
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Cure mainly epidemic febrile disease heating, pyretic toxicity disorders of blood, toxic swelling and erysipelas etc.
Radix Et Rhizoma Rhei: purging heat to relax the bowels, removing toxicity for eliminating carbuncles, removing damp-heat.For damp and hot stagnant, the constipation of gastrointestinal, abdominal part distension and pain with tenderness, even for hyperpyrexia and unconsciousness and delirium.
Radix Platycodonis: bitterness, suffering, property are flat, have calmness, analgesia, refrigeration function, and modern study shows, Radix Platycodonis and effective ingredient thereof have the multiple pharmacological effect such as antiinflammatory, calmness, immunomodulating.
Folium Microcoris paniculatae: relieving dyspepsia, clearing away heat-damp and promoting diuresis.For eating accumulation, cold anemopyretic and damp and hot yellow disease.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.Cure mainly epidemic febrile disease, upper respiratory tract infection, jaundice due to damp-heat and carbuncle sore tumefacting virus.
Traditional medicine has original understanding to porcine hyperthermia, thinks that this disease belongs to damp and hot and accumulates long-pendingly, and pyretic toxicity is progressively invaded due to defensive-qi-nutrient-blood.
According to Chinese veterinarian monarch, minister, the principles of formulating prescriptions helping, make, in side, select after Radix Et Rhizoma Rhei under, there is the effect of clearing away heat-fire, cooling blood and dissolving stasis, stasis removing, make heat from go out; Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens, make heat from sweating, and Radix Et Rhizoma Rhei, Flos Lonicerae two medicines share, and make the Re Chuyou road, are monarch drug altogether.Folium Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, Radix Platycodonis lung qi dispersing sore-throat relieving, alleviate pharyngalgia dry pharynx symptom, is ministerial drug altogether.Radix Scutellariae heat clearing and damp drying, removing heat from blood, the Folium Microcoris paniculatae heat clearing away disappears stagnant, dampness removing jaundice eliminating, two medicines are adjuvant drug altogether.Full side's heat clearing away and the same use of light solution, diaphoresis and diuresis develop simultaneously, and have the effect of heat-clearing and toxic substances removing, damp eliminating, anti-inflammation, for porcine hyperthermia, have good effects.
The present invention has also disclosed a kind of preparation method of preventing and treating the medicine of porcine hyperthermia, and its step is as follows:
(1) take each raw material by above-mentioned formula ratio, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3 step (1) Radix Platycodoniss afterwards of learning from else's experience, in the ethanol that to add to volume fraction be 70%, and adopt the reflux, extract, instrument to extract 4 times, and each time is 1.5h, and wherein, the amount of alcohol that volume fraction is 70% is 4 times of Radix Platycodonis weight, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.28 ~ 1.32, obtain preventing and treating the medicine of porcine hyperthermia.
Described in step (3), the volume fraction of ethanol is 70%, the addition of ethanol is Radix Platycodonis 4 times.
The above-mentioned material of mentioning obtains by commercial, described reflux, extract, instrument is existing product, reflux, extract, technology and concentrating under reduced pressure technology are prior art, and those skilled in the art can be according to the above-mentioned step of mentioning of existing techniques in realizing, therefore this content is not done and is described in detail one by one.
For those skilled in the art's understanding, below by specific embodiment, the present invention is described in further detail.
Embodiment mono-, and the present embodiment mixes the medicine of the control porcine hyperthermia of gained with starch, is prepared into powder and uses.
A kind of preparation method of preventing and treating the medicine of porcine hyperthermia, its step is as follows:
(1) take by weight 20 parts of 30 parts of Folium Isatidiss, 40 parts of Flos Loniceraes, 30 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Platycodoniss, 20 parts of Folium Microcoris paniculataes and Radix Scutellariaes, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae is to add after boiling again, and filtered while hot obtains filtrate 1;
(3 step (1) Radix Platycodoniss afterwards of learning from else's experience, in the ethanol that to add to volume fraction be 70%, and adopt the reflux, extract, instrument to extract 4 times, and each time is 1.5h, and wherein, the amount of alcohol that volume fraction is 70% is 4 times of Radix Platycodonis weight, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.28, obtain preventing and treating the medicine of porcine hyperthermia.
The preparation of powder: take medicine as 100 parts of meterings, to the starch that adds 30-50 part in the medicine of the control porcine hyperthermia of above-mentioned thick paste shape, then dry, pulverize, cross 120 mesh sieves, obtain powder.Powder to the present embodiment gained is detected, and show that every 1g powder is equivalent to crude drug in whole 2g.
The using method of gained powder is as follows:
While being used for the treatment of, add the present embodiment powder 500g in every 1000Kg feedstuff, be used in conjunction 7 days; Add the present embodiment powder 300g in every 1000L water, be used in conjunction 7 days.While being used for preventing, the addition of powder reduces by half, and is used in conjunction 5 days and gets final product.The use amount of feedstuff and water is determined according to the use amount of every pig under regular situation.
Embodiment bis-, and the present embodiment mixes the medicine of the control porcine hyperthermia of gained with dextrin and Icing Sugar, are prepared into granule and use.
A kind of preparation method of preventing and treating the medicine of porcine hyperthermia, its step is as follows:
(1) take by weight 90 parts of 110 parts of Folium Isatidiss, 140 parts of Flos Loniceraes, 120 parts of Radix Et Rhizoma Rhei, 100 parts of Radix Platycodoniss, 75 parts of Folium Microcoris paniculataes and Radix Scutellariaes, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3) step (1) Radix Platycodonis afterwards of learning from else's experience, in the ethanol that to add to volume fraction be 70%, and adopt the reflux, extract, instrument to extract 4 times, and each time is 1.5h, and wherein, the amount of alcohol that volume fraction is 70% is 4 times of Radix Platycodonis weight, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, carry out concentrating under reduced pressure under the condition that is then 70 ℃ in temperature, and being concentrated into the filtrate relative density is 1.32, obtains preventing and treating the medicine of porcine hyperthermia.
The preparation of granule: take medicine as 100 parts of meterings, to the dextrin and the Icing Sugar that add 60-90 part in the medicine of the control porcine hyperthermia of above-mentioned thick paste shape, dried after mix homogeneously, pulverized, cross 120 mesh sieves, make soft material, cross 16 mesh sieves and granulate, being dried to water content under 60 ℃ of conditions is 4%, obtains granule.Granule to the present embodiment gained is detected, and show that every 1g granule is equivalent to crude drug in whole 1.5g.
The using method of gained granule is as follows:
While being used for the treatment of, add the present embodiment granule 150g in every 1000Kg feedstuff, be used in conjunction 7 days; Add the present embodiment granule 90g in every 1000L water, be used in conjunction 7 days.While being used for preventing, the addition of granule reduces by half, and is used in conjunction 5 days and gets final product.The use amount of feedstuff and water is determined according to the use amount of every pig under regular situation.
Embodiment tri-, and the present embodiment mixes the medicine of the control porcine hyperthermia of gained with dextrin, Icing Sugar and magnesium stearate, are prepared into tablet and use.
A kind of preparation method of preventing and treating the medicine of porcine hyperthermia, its step is as follows:
(1) take by weight 60 parts of 85 parts of Folium Isatidiss, 90 parts of Flos Loniceraes, 50 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Platycodoniss, 50 parts of Folium Microcoris paniculataes and Radix Scutellariaes, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3) step (1) Radix Platycodonis afterwards of learning from else's experience, in the ethanol that to add to volume fraction be 70%, and adopt the reflux, extract, instrument to extract 4 times, and each time is 1.5h, and wherein, the amount of alcohol that volume fraction is 70% is 4 times of Radix Platycodonis weight, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.30, obtain preventing and treating the medicine of porcine hyperthermia.
The preparation of tablet: take medicine as 100 parts of meterings, to the dextrin and the hydroxypropyl emthylcellulose that add 40-70 part in the medicine of the control porcine hyperthermia of above-mentioned thick paste shape, dried after mix homogeneously, pulverized, cross 120 mesh sieves, make soft material, cross 16 mesh sieves and granulate, being dried to water content under 60 ℃ of conditions is 4%, the magnesium stearate that adds 3-5 part, tabletting, obtain tablet.Tablet to the present embodiment gained is detected, and show that every 1g tablet is equivalent to crude drug in whole 1.5g.
The using method of gained tablet is as follows:
While being used for the treatment of, add the present embodiment tablet 150g in every 1000Kg feedstuff, be used in conjunction 7 days; While being used for preventing, the addition of tablet reduces by half, and is used in conjunction 5 days and gets final product.The feedstuff use amount is determined according to the use amount of every pig under regular situation.
Embodiment tetra-, and the present embodiment mixes the medicine of the control porcine hyperthermia of gained with dextrin and hydroxypropyl emthylcellulose, are prepared into capsule and use.
A kind of preparation method of preventing and treating the medicine of porcine hyperthermia, its step is as follows:
(1) take by weight 70 parts of 90 parts of Folium Isatidiss, 110 parts of Flos Loniceraes, 70 parts of Radix Et Rhizoma Rhei, 40 parts of Radix Platycodoniss, 70 parts of Folium Microcoris paniculataes and Radix Scutellariaes, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3) step (1) Radix Platycodonis afterwards of learning from else's experience, in the ethanol that to add to volume fraction be 70%, and adopt the reflux, extract, instrument to extract 4 times, and each time is 1.5h, and wherein, the amount of alcohol that volume fraction is 70% is 4 times of Radix Platycodonis weight, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.31, obtain preventing and treating the medicine of porcine hyperthermia.
The preparation of capsule: take medicine as 100 parts of meterings, to the dextrin and the hydroxypropyl emthylcellulose that add 50-70 part in the medicine of the control porcine hyperthermia of above-mentioned thick paste shape, dried after mix homogeneously, pulverized, cross 120 mesh sieves, be filled into capsule No. 0, obtain capsule.Capsule to the present embodiment gained is detected, and show that every 1g capsule is equivalent to crude drug in whole 1.5g.
The using method of gained capsule is as follows:
While being used for the treatment of, add the present embodiment capsule 150g in every 1000Kg feedstuff, be used in conjunction 7 days; While being used for preventing, the addition of capsule reduces by half, and is used in conjunction 5 days and gets final product.The use amount of feedstuff is determined according to the use amount of every pig under regular situation.
Embodiment five, and the present embodiment mixes the medicine of the control porcine hyperthermia of gained with potassium sorbate, are prepared into oral liquid and use.
A kind of preparation method of preventing and treating the medicine of porcine hyperthermia, its step is as follows:
(1) take by weight 40 parts of 50 parts of Folium Isatidiss, 65 parts of Flos Loniceraes, 95 parts of Radix Et Rhizoma Rhei, 70 parts of Radix Platycodoniss, 35 parts of Folium Microcoris paniculataes and Radix Scutellariaes, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, the Folium Microcoris paniculatae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3) step (1) Radix Platycodonis afterwards of learning from else's experience, in the ethanol that to add to volume fraction be 70%, and adopt the reflux, extract, instrument to extract 4 times, and each time is 1.5h, and wherein, the amount of alcohol that volume fraction is 70% is 4 times of Radix Platycodonis weight, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.29, obtain preventing and treating the medicine of porcine hyperthermia.
The preparation of oral liquid: take medicine as 100 parts of meterings, in the medicine of above-mentioned control porcine hyperthermia, add 2 parts of potassium sorbate, mix homogeneously, filter, embedding, and sterilizing, make oral liquid.Oral liquid to the present embodiment gained is detected, and show that every 1ml oral liquid is equivalent to crude drug in whole 1.5g.
The using method of gained oral liquid is as follows:
While being used for the treatment of, add the present embodiment oral liquid 150ml in every 1000Kg feedstuff, be used in conjunction 7 days; Add the present embodiment oral liquid 90ml in every 1000L water, be used in conjunction 7 days.While being used for preventing, the addition of oral liquid reduces by half, and is used in conjunction 5 days and gets final product.The use amount of feedstuff and water is determined according to the use amount of every pig under regular situation.
In order to show the prevention effect of medicine of the present invention to porcine hyperthermia, medicine of the present invention has been carried out to the clinical observation on the therapeutic effect test, below by test example, further set forth the beneficial effect of medicine of the present invention:
(1) test drug: the powder that test group 1 medicine is embodiment 1 preparation; The granule that test group 2 medicines are embodiment 2 preparations; The capsule that test group 3 medicines are embodiment 3 preparations; The tablet that test group 4 medicines are embodiment 4 preparations; The oral liquid that test group 5 medicines are embodiment 5 preparations.
(2) experimental animal: this test piglet all is selected from Guangdong Province's Qingyuan City, Shaoguan, pig farm, Guangzhou natural occurrence without 360 of Shantou piglets of 40～50 ages in days of any treatment, body weight 15～30Kg, have spirit depressed, do not eat, rapid breathing, ventral breathing, exhaustion are unable, palor, diarrhoea or constipation, skin and the classical symptoms such as ear cyanosis, fervescence.
(3) test method: 360 of test pig are divided into 6 groups at random, 60 every group.1～5 group of test group, adopt respectively embodiment 1～5 to prepare medicine, and, respectively according to the therapeutic dose administration in the embodiment of the present invention 1～5 using method, be used in conjunction 7 days.Matched group is not given any medicine.
(4) statistical method: application SPSS16.0 software data processing adopts X 2 test.
(5) evaluation index: cure: transference cure, appetite is normal, and the mental status is better; Effectively: symptom is good, and body temperature is normal, and appetite increases, and the mental status is good; Invalid: symptom is not improved, death.
Cure rate=piglet is cured number ÷ test piglet sum * 100%;
Effective percentage=piglet treatment significant figure ÷ test piglet sum * 100%.
(6) result of the test is as shown in table 1:
| Group | Cure number/head | Cure rate/% | Significant figure/head | Effective percentage/% |
| Test group 1 | 26 | 86.67 | 28 | 93.33 |
| Test group 2 | 25 | 83.33 | 26 | 86.67 |
| Test group 3 | 27 | 90.00 | 29 | 96.67 |
| Test group 4 | 26 | 86.67 | 27 | 90.00 |
| Test group 5 | 25 | 83.33 | 26 | 86.67 |
| Matched group | 0 | 0.00 | 0 | 0.00 |
Table 1
(7) conclusion (of pressure testing): 5 groups of medicine of the present invention and matched group cure rate, effective percentage all have significant difference (
p<0.05), 1 ~ 5 pair of porcine hyperthermia of test group all has significant curative effect.
Known by above-mentioned test, the dialectical principle treated of medicine of the present invention performance Chinese medicinal formulae, the characteristics such as it has good effect, instant effect, has no drug resistance, heat-clearing and toxic substances removing, anti-inflammation, environmental protection and noresidue, for prevention and treatment porcine hyperthermia.
In addition, pharmaceutical preparation of the present invention is simple, with low cost, has the stronger market competitiveness.The source of medicine material of the present invention is abundant, and moderate cost is applicable to suitability for industrialized production and application.
The content of mentioning in above-described embodiment is not limitation of the invention, and under the prerequisite that does not break away from inventive concept of the present invention, any apparent replacement is all within protection scope of the present invention.
Claims (3)
1. a medicine of preventing and treating porcine hyperthermia, be comprised of with 20 ~ 90 parts of Radix Scutellariaes 20 ~ 75 parts of 10 ~ 100 parts of 20 ~ 120 parts of 40 ~ 140 parts of 30 ~ 110 parts of Folium Isatidiss, Flos Loniceraes, Radix Et Rhizoma Rhei, the Radix Platycodoniss, the Folium Microcoris paniculataes that measure by weight;
And this drug matching mixes with pharmaceutically acceptable adjuvant, is prepared into powder, granule, capsule, tablet or oral liquid; Described adjuvant is one or both combinations in starch, dextrin, Icing Sugar, hydroxypropyl emthylcellulose and potassium sorbate.
2. the preparation method of the medicine of a control porcine hyperthermia according to claim 1, its step is as follows:
(1) take each raw material by claim 1 formula ratio, after pulverizing, cross 24 mesh sieves;
(2) step (1) Folium Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, Folium Microcoris paniculatae and the Radix Scutellariae afterwards of learning from else's experience, soak 60min after mix homogeneously, the water yield is 8 times of each raw material gross weight, decoct 2 times, decoct for the first time 2h, decoct for the second time 1h, wherein Radix Scutellariae adds after boiling again, and filtered while hot obtains filtrate 1;
(3) learn from else's experience Radix Platycodonis afterwards of step (1) adding in ethanol, adopt the reflux, extract, instrument to extract 4 times, and each time of extracting is 1.5h, and filtered while hot obtains filtrate 2;
(4) filtrate 1 of step (2) gained is mixed homogeneously with the filtrate 2 of step (3) gained, standing 12h, then carry out concentrating under reduced pressure under the condition that is 70 ℃ in temperature, the thick paste shape that to be concentrated into the filtrate relative density be 1.28 ~ 1.32, obtain preventing and treating the medicine of porcine hyperthermia.
3. the preparation method of the medicine of control porcine hyperthermia according to claim 2, it is characterized in that: described in step (3), the volume fraction of ethanol is 70%, the addition of ethanol is Radix Platycodonis 4 times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310318565.XA CN103432215B (en) | 2013-07-26 | 2013-07-26 | A kind of medicine preventing and treating porcine hyperthermia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310318565.XA CN103432215B (en) | 2013-07-26 | 2013-07-26 | A kind of medicine preventing and treating porcine hyperthermia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103432215A true CN103432215A (en) | 2013-12-11 |
| CN103432215B CN103432215B (en) | 2016-03-02 |
Family
ID=49686000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310318565.XA Active CN103432215B (en) | 2013-07-26 | 2013-07-26 | A kind of medicine preventing and treating porcine hyperthermia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103432215B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750042A (en) * | 2014-01-13 | 2014-04-30 | 凤台县双瑞农业发展有限公司 | Epidemic prevention composite pig feed used in summer |
| CN106138915A (en) * | 2016-07-16 | 2016-11-23 | 朱广双 | For treating the preparation method of the Chinese medicine preparation of porcine hyperthermia |
| CN106421607A (en) * | 2016-11-07 | 2017-02-22 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine capable of improving piglet immunity and preparation method thereof |
| CN111135210A (en) * | 2019-12-05 | 2020-05-12 | 广东容大生物股份有限公司 | Production method of medicine for treating African swine fever |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961468A (en) * | 2010-10-28 | 2011-02-02 | 清远容大生物工程有限公司 | Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof |
| US20120093951A1 (en) * | 2009-06-16 | 2012-04-19 | Desheng Tao | Traditional chinese medicine composition for treating swine influenza, preparation method and use thereof |
| CN102600334A (en) * | 2012-03-18 | 2012-07-25 | 李运乃 | Traditional Chinese preparation for treating obstruction of auditory tube and ear pain symptom under warm climate condition |
| CN102600305A (en) * | 2011-12-22 | 2012-07-25 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating swine pasteurellosis and preparation method for same |
-
2013
- 2013-07-26 CN CN201310318565.XA patent/CN103432215B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120093951A1 (en) * | 2009-06-16 | 2012-04-19 | Desheng Tao | Traditional chinese medicine composition for treating swine influenza, preparation method and use thereof |
| CN101961468A (en) * | 2010-10-28 | 2011-02-02 | 清远容大生物工程有限公司 | Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof |
| CN102600305A (en) * | 2011-12-22 | 2012-07-25 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating swine pasteurellosis and preparation method for same |
| CN102600334A (en) * | 2012-03-18 | 2012-07-25 | 李运乃 | Traditional Chinese preparation for treating obstruction of auditory tube and ear pain symptom under warm climate condition |
Non-Patent Citations (2)
| Title |
|---|
| 冯洪钱: "《兽医本草拾遗》", 30 September 2002, article "猪感冒高热", pages: 103 * |
| 刘明国等: "糖苷化合物功能简介", 《湖北三峡学院学报》, no. 2, 30 April 2000 (2000-04-30), pages 51 - 54 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750042A (en) * | 2014-01-13 | 2014-04-30 | 凤台县双瑞农业发展有限公司 | Epidemic prevention composite pig feed used in summer |
| CN106138915A (en) * | 2016-07-16 | 2016-11-23 | 朱广双 | For treating the preparation method of the Chinese medicine preparation of porcine hyperthermia |
| CN106421607A (en) * | 2016-11-07 | 2017-02-22 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine capable of improving piglet immunity and preparation method thereof |
| CN111135210A (en) * | 2019-12-05 | 2020-05-12 | 广东容大生物股份有限公司 | Production method of medicine for treating African swine fever |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103432215B (en) | 2016-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102526525B (en) | Traditional Chinese medicine composition for treating transmissible gastroenteritis of swine | |
| CN103893272A (en) | Pharmaceutical composition for treating livestock diarrhea and preparation method thereof | |
| CN103860714B (en) | A kind of compound Chinese medicine extract and application thereof preventing and treating livestock and poultry diarrhea syndrome | |
| CN103933128B (en) | Pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof | |
| CN103432215B (en) | A kind of medicine preventing and treating porcine hyperthermia and preparation method thereof | |
| CN103432255A (en) | Chinese medicine granule for controlling fish lepidorthosis and preparation method thereof | |
| CN103181970A (en) | Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method for same | |
| CN104208393B (en) | It is a kind of to be used to prevent Chinese medicine composition of infectious bronchitis of chicken and preparation method thereof | |
| CN101152465B (en) | Oral liquid for anti-fever and smoothing asthma of hyperpyrexia syndrome and its preparation method | |
| CN103272091A (en) | Traditional Chinese medicinal oral preparation for treating chicken coccidiosis and preparation method thereof | |
| CN101940651B (en) | Traditional Chinese medicine superfine powder for preventing and treating chicken colibacillosis and preparation method thereof | |
| CN102895569A (en) | Traditional Chinese medical oral solution for treatment of proventriculitis and ventriculitis of chicken and preparation method thereof | |
| CN101961468B (en) | Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof | |
| CN102716282A (en) | Traditional Chinese medicine granule for preventing and treating chicken fowl paralysis and method for preparing traditional Chinese medicine granule | |
| CN102961686A (en) | Oral liquid for treating canine distemper and preparation method of oral liquid | |
| CN104857376A (en) | Compound traditional Chinese medicine capable of promoting growing of broilers | |
| CN103054985B (en) | Pure Chinese medicinal composition for treating red fin disease of eels and preparation method of pure Chinese medicinal composition | |
| CN102697959B (en) | Veterinary drug of traditional Chinese veterinary drug for preventing and treating porcine respiratory disease syndrome | |
| CN105250408B (en) | A kind of Chinese medicine composition for treating an avian adenovirus infection | |
| CN103861007B (en) | A kind of Chinese herbal compound preparation for the treatment of chicken diarrhea | |
| CN106511813A (en) | Drug for treating duck virus hepatitis | |
| CN104161817B (en) | A kind of compound traditional Chinese medicine composite for preventing and treating chicken bacterial disease and preparation method thereof | |
| CN102526356B (en) | Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry | |
| CN104147399A (en) | Pharmaceutical preparation for swine fever | |
| CN103656302A (en) | Chinese herbal medicine granule for treating pertussis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 511500, No. two, No. 31, Qingyuan hi tech Industrial Development Zone, Guangdong Province Applicant after: GUANGDONG RONGDA BIOLOGY Co.,Ltd. Address before: 511517 bio pharmaceutical City, Qingyuan hi tech Industrial Development Zone, Guangdong Applicant before: QINGYUAN CONTAIN BIOENGINEERING Co.,Ltd. |
|
| COR | Change of bibliographic data | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yang Xinghang Inventor after: Wu Yangkai Inventor after: Liu Zongxin Inventor after: Jiang Shunjin Inventor before: Wu Yangkai Inventor before: Liu Zongxin Inventor before: Hong Kaidong Inventor before: Liu Yuanjiang Inventor before: Jiang Shunjin Inventor before: Lai Xiuping |
|
| COR | Change of bibliographic data | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A drug for prevention and treatment of swine high fever and its preparation method Effective date of registration: 20200909 Granted publication date: 20160302 Pledgee: Bank of China Limited Qingyuan Branch Pledgor: GUANGDONG RONGDA BIOLOGY Co.,Ltd. Registration number: Y2020440000253 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20160302 Pledgee: Bank of China Limited Qingyuan Branch Pledgor: GUANGDONG RONGDA BIOLOGY Co.,Ltd. Registration number: Y2020440000253 |