CN101961468A - Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof - Google Patents
Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome, which comprises the following components in parts by weight: 10-100 parts of weeping forsythia, 30-150 parts of honeysuckle flower, 20-120 parts of dyer woad leaf, 10-50 parts of blackberrykiky rhizome, 10-100 parts of baical skullcap roots, 10-80 parts of microcos paniculata leaves and 5-40 parts of semen coicis. The invention also discloses a preparation method of the traditional Chinese medicinal composition, which comprises the following steps of: crushing or directly extracting the raw materials; and concentrating and adding frequently used auxiliary materials or auxiliary components in pharmacy to prepare the composition. The traditional Chinese medicinal composition has the advantages of good treatment effect, rapid effect taking, no medicine residue and no drug resistance; and meanwhile, the preparation method is simple and easy to operate, stable in product quality and applicable to wide application.
Description
Technical field
The present invention relates to field of veterinary, be specifically related to a kind of Chinese medicine composition of preventing and treating the porcine respiratory syndrome and preparation method thereof.
Background technology
Porcine respiratory disease syndrome (porcine respiratory disease complex, PRDC) be a kind of multiple-factor disease, be by various bacteria, virus, mycoplasma, environmental stress and pig resistance reduce, the general name of the respiratory tract disease that many factor interactions cause such as feeding and management condition is bad.The porcine respiratory syndrome mainly betides the pig of breeding in 13 ~ 20 ages in week, and general sickness rate is 25 ~ 60%, and morbidity pig mortality rate is 20 ~ 90%, and the more little case fatality rate of age in days is high more.Sick pig spirit is depressed, and feed intake descends or do not have appetite, serious ventral breathing occurs, and asthma is rapid, dyspnea, and cough, discharge of eye increases, and the conjunctivitis symptom occurs; Sow miscarriage, stillborn fetus, mummy, return feelings rate height; Piglet and fattening pig are weak, diarrhoea, poor growth or stagnation.The temperature of pig body of acute onset raises, and sudden death can take place.Primary disease has since nineteen ninety-five become the No.1 disease of the global pig industry economic benefit of influence.
The problem that the modernization pig industry perplexs most is exactly a respiratory tract disease, and respiratory tract disease has also increased the treatment cost except the only direct death of pig, reduce feed conversion rate, cause the pig poor growth, postpone listing and manage upward vicious cycle etc., make Swine Production suffer heavy losses.Respiratory tract disease is the result of many combined factors effects, and these factors comprise: society, environment, feeding and management, stress, zymad, feedstuff, medicine or the like.The cause of disease that causes PRDC is broadly divided into constitutional cause of disease and Secondary cases cause of disease two big classes.The constitutional cause of disease has mycoplasma hyopneumoniae (MH), pig breeding and breathing syndrome virus (being commonly called as reproductive and respiratory syndrome PRRSV), Pseudorabies virus (ADV), swine influenza virus (SIV), PRCV (Porcine Respiratory Coronavirus) (PRCV), actinobacillus pleuropneumoniae (APP), porcine circovirus II type (PCV-II) etc.The Secondary cases cause of disease has pasteurella multocida (PM), Streptococcus suis (SS), the secondary haemophilus (HP) of pig, mycoplasma hyorhinis (MHR), inclusion-body rhinitis virus of pigs (PCMV), Salmonella choleraesuls (SC) etc.
In recent years, some new features have appearred in respiratory tract disease syndrome than before, the pathogen that shows as mixed infection changes more to some extent, the infection that is transferred to mycoplasma pneumoniae breeding and breathing syndrome virus, circovirus type II cause of diseases such as (PCV-2) by former antibacterial and virus mixed infection is main, again in conjunction with other the antibacterial or the secondary and the mixed infection of virus (as pasteurellosis bacillus, streptococcus, Actinobacillus pleuropneumoniae, secondary haemophilus, influenza virus etc.), the cause of disease kind that infects is many, and difficulty of prevention and cure is big.
The Western medicine commonly used of prevention and treatment porcine respiratory syndrome has taimulin, oxytetracycline, chlortetracycline, enrofloxacin, amoxicillin etc.But the Western medicine side effect is big, usage and consumption seldom are more prone to cause secondary infection, increase the weight of the symptom of the respiratory tract disease of pig, and Western medicine causes the product veterinary drug residue to exceed standard easily, easily produce drug resistance, so need certain off-drug period to guarantee the safety of livestock products after using Western medicine.
Liu Lihua etc. have reported that treatment porcine respiratory disease syndrome antibacterial Chinese herbal medicines preparation commonly used has CHUANXINLIAN ZHUSHEYE, YINQIAO injection etc.(referring to " application of antibacterial Chinese herbal medicines on control porcine respiratory syndrome ", in November, 2008 total 235 phases of poultry industry, pig farm veterinary, 70 ~ 71).Shen Huawei has reported that several Chinese medicinal formulaes are (referring to animal science and animal medicine in " applied research of Chinese herbal medicine in control porcine respiratory disease syndrome (PRDC) ", November the 21st in 2004 was rolled up o. 11th, 50 ~ 51), but all undeclared prevention effect how.
Chinese patent application 200410022889.X(is day on May 4th, 2005 openly, publication number CN1611258A) a kind of pharmaceutical composition for the treatment of typhoid fever is disclosed, with Folium Isatidis, Radix Rehmanniae is monarch drug, and Caulis Akebiae, Herba Artemisiae Scopariae, Radix Scrophulariae, Radix Ophiopogonis are ministerial drug, and assistant is with Flos Lonicerae, Fructus Forsythiae etc.Can treat each parenteric fever or paratyphoid fever or patient that both have concurrently.
Chinese patent application 200710113245.5(is day on April 30th, 2008 openly, publication number CN101167808A) disclose a kind of Chinese herbal medicine pre-mixing agent that prevents porcine hyperthermia, main component is the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Folium Isatidis, Echinacea, Periostracum Cicadae, Venenum Bufonis, Borneolum Syntheticum etc.Can prevent and treat porcine hyperthermia.
Chinese patent application 200710150041.9(is day on May 16th, 2009 openly, publication number CN101422575) discloses a kind of Chinese medicine oral liquid that is used for the treatment of livestock and poultry respiratory tract infection, comprised Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae, Radix Scutellariae, Ramulus Cinnamomi, Radix Glycyrrhizae, Herba Epimedii, Folium Isatidis, Radix Isatidis, Herba Schizonepetae, Radix Saposhnikoviae, Plantula Papaveris 12 herbal medicines.This medicine is applicable to the disease that the respiratory tract infection of treatment poultry causes.
Chinese patent application 201010128586.1(is day on July 21st, 2010 openly, publication number CN101780180A) a kind of preparation method of Chinese medicine for the treatment of early pulmonary abscess is disclosed, with Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Radix Isatidis, Herba Patriniae, Herba Houttuyniae, Caulis Sargentodoxae, Fructus Canarii, Herba Menthae, Herba Schizonepetae, Radix Saposhnikoviae, Semen Sojae Preparatum, Fructus Arctii is monarch drug, five-leaved chaste tree, Semen Armeniacae Amarum, Rhizoma Cynanchi Stauntonii, Radix Asteris, Flos Farfarae, Semen Ginkgo, Fructus Perillae are ministerial drug, add Radix Platycodonis and Radix Glycyrrhizae, make the Chinese medicine of treatment early pulmonary abscess.
Summary of the invention
The objective of the invention is to overcome above-mentioned deficiency in the prior art, a kind of good effect, no drug residue and drug resistance are provided, and have the Chinese medicinal formulae of heat-clearing and toxic substances removing, anti-inflammation, resolving phlegm and relieving asthma effect, be primarily aimed at the Chinese medicine composition of control porcine respiratory syndrome.
Another object of the present invention is to provide the application of above-mentioned Chinese medicine composition in control porcine respiratory syndrome.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition of preventing and treating the porcine respiratory syndrome comprises following component and parts by weight: 10 ~ 100 parts of Fructus Forsythiaes, 30 ~ 150 parts of Flos Loniceraes, 20 ~ 120 parts of Folium Isatidiss, 10 ~ 50 parts of Rhizoma Belamcandae, 10 ~ 100 parts of Radix Scutellariaes, 10 ~ 80 parts of Folium Microcoris paniculataes, 5 ~ 40 parts of Semen Coiciss.
The parts by weight of primary raw material are preferably: 50 ~ 100 parts of Fructus Forsythiaes, 80 ~ 150 parts of Flos Loniceraes, 80 ~ 120 parts of Folium Isatidiss, 30 ~ 50 parts of Rhizoma Belamcandae, 50 ~ 100 parts of Radix Scutellariaes, 40 ~ 80 parts of Folium Microcoris paniculataes, 10 ~ 30 parts of Semen Coiciss.
Parts by weight the best of primary raw material is: 80 parts of Fructus Forsythiaes, 100 parts of Flos Loniceraes, 90 parts of Folium Isatidiss, 40 parts of Rhizoma Belamcandae, 80 parts of Radix Scutellariaes, 60 parts of Folium Microcoris paniculataes, 15 parts of Semen Coiciss.
The present invention selects for use the effect of raw material to be summarized as follows:
Fructus Forsythiae: hardship is slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Be used for carbuncle, acute mastitis, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, coma is sent out speckle, the puckery pain of pyretic stranguria.
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Cure mainly the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, cards such as anal fistula.
Folium Isatidis: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Be used for the epidemic febrile disease heating, send out the speckle dermexanthesis, anemopyretic cold, laryngopharynx swelling and pain, pneumonia, parotitis, epidemic cerebrospinal meningitis, encephalitis B, erysipelas, carbuncle.
Rhizoma Belamcandae: heat-clearing and toxic substances removing, expectorant, sore-throat relieving is used for pyretic toxicity expectorant heat stagnation knot, laryngopharynx swelling and pain, cough and asthma.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Folium Microcoris paniculatae: relieving dyspepsia, clearing away heat-damp and promoting diuresis.Be used for eating accumulation, cold anemopyretic, jaundice due to damp-heat.
Semen Coicis: sweet, light, cool.Return spleen, stomach, lung meridian.Promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens.
Main and auxiliary according to Chinese veterinarian, as to help, the make principles of formulating prescriptions, Fructus Forsythiae, Flos Lonicerae, Folium Isatidis have heat-clearing and toxic substances removing in the side, and dispelling wind and heat pathogens has effects such as heart tonifying, diuresis, the various antibacterials of inhibition and virus, is the principal agent in the side.Rhizoma Belamcandae, Radix Scutellariae have heat clearing and damp drying, expectorant, and effects such as sore-throat relieving are the accessory drugs in the side.Folium Microcoris paniculatae, Semen Coicis have effects such as clearing away heat-damp and promoting diuresis, invigorating the spleen to arrest diarrhea, are the adjuvant in the side.All medicines share, and have the effect of heat-clearing and toxic substances removing, anti-inflammation, resolving phlegm and relieving asthma, are primarily aimed at porcine respiratory syndrome disease and have good efficacy.
Chinese medicine composition of the present invention can be prepared into powder, powder, tablet, granule, oral liquid or injection.
The present invention also provides the preparation method of Chinese medicine of this control porcine respiratory syndrome, and step is as follows:
When the Chinese medicine composition dosage form was powder, preparation method may further comprise the steps:
(1) each medicine material is pulverized by the proportioning back of weighing, crossed 60 mesh sieves;
(2) step (1) products therefrom is added adjuvant or complementary composition commonly used in the pharmacy, conventional method is prepared into patent medicine;
When the Chinese medicine composition dosage form was powder, tablet, granule, oral liquid or injection, preparation method may further comprise the steps:
(1) each medicine material is weighed by proportioning;
(2) each medicine material is mixed, extract again, filter, concentrate;
(3) will concentrate products therefrom and add adjuvant or complementary composition commonly used in the pharmacy, conventional method is prepared into patent medicine.
When the Chinese medicine composition dosage form is powder, tablet, granule, oral liquid or injection, extract described in the step (2) and be meant with 6 ~ 10 times of water gagings immersions 10 ~ 40 minutes, be heated to boiling, extract twice, 1 ~ 2 hour for the first time, 1 ~ 2 hour for the second time, so that the effective ingredient in the medicine material fully is dissolved in the water.
When the Chinese medicine composition dosage form was powder, tablet, granule, oral liquid or injection, simmer down to described in the step (2) is condensed into relative density in the time of 70 ℃ be 1.13 ~ 1.18 clear paste.
Adjuvant or the complementary composition used always in the pharmacy described in the preparation method of Chinese medicine of above-mentioned control porcine respiratory syndrome are: starch, dextrin, sucrose, magnesium stearate etc.
The Chinese medicine of control porcine respiratory syndrome of the present invention can be used for preparation control porcine respiratory syndrome medicament, and simultaneously, Chinese medicine of the present invention also can add in the feedstuff, the feedstuff of preparation control porcine respiratory syndrome.
The advantage and the effect of Chinese medicine composition of the present invention are:
(1) combined effect of Chinese medicine performance Chinese medicinal formulae of the present invention determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, good effect, instant effect, environmental protection, noresidue, the difficult drug resistance that produces can be used for preventing and treating the porcine respiratory syndrome.
(2) Chinese medicine preparation technology of the present invention is simple, cost is low, has the stronger market competitiveness.
(3) raw material of Chinese medicine of the present invention is originated and is enriched, and moderate cost is suitable for extensive use.
The specific embodiment
Embodiment 1
Fructus Forsythiae 100g, Flos Lonicerae 150g, Folium Isatidis 120g, Rhizoma Belamcandae 50g, Radix Scutellariae 100g, Folium Microcoris paniculatae 80g, Semen Coicis 40g.
Preparation method and using method are as follows:
(1) takes by weighing the raw material that contains above-mentioned prescription weight;
(2) with claim in the step (1) each weight crude drug pulverize, cross 60 mesh sieves after, fully be mixed with into powder.
Drug use method of the present invention: the porcine respiratory syndrome, mixed feeding: every 1kg feedstuff adds Chinese medicine 4g of the present invention, logotype 5 days.
Embodiment 2
Fructus Forsythiae 10g, Flos Lonicerae 30g, Folium Isatidis 20g, Rhizoma Belamcandae 10g, Radix Scutellariae 10g, Folium Microcoris paniculatae 10g, Semen Coicis 5g.
Preparation method and using method are as follows:
(1) takes by weighing the raw material that contains above-mentioned prescription weight;
(2) with claim in the step (1) each weight crude drug pulverize after, with 10 times of water yields medical material is soaked 30 minutes earlier after, extracts 2 times, 1.5 hours first time, 1 hour second time, merging filtrate also is condensed into the thick paste shape; Add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously, oven dry is pulverized, and promptly is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
Drug use method of the present invention: the porcine respiratory syndrome, mixed feeding: every 1kg feedstuff adds Chinese medicine 2g of the present invention, logotype 5 days.
Embodiment 3
Fructus Forsythiae 80g, Flos Lonicerae 100g, Folium Isatidis 90g, Rhizoma Belamcandae 40g, Radix Scutellariae 80g, Folium Microcoris paniculatae 60g, Semen Coicis 15g.
Preparation method and using method are as follows:
(1) takes by weighing the raw material that contains above-mentioned prescription weight;
(2) with claim in the step (1) each weight crude drug pulverize after, with 10 times of water yields medical material is soaked 30 minutes earlier after, extracts 2 times, 1.5 hours first time, 1 hour second time, merging filtrate also is condensed into the thick paste shape; Add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously is made soft material, granulates, and oven dry promptly is prepared into granule (every 1g is equivalent to crude drug in whole 1g).
Drug use method of the present invention: the porcine respiratory syndrome, mix drink: every 1L water adds Chinese medicine 2g of the present invention, freely drinks logotype 5 days.
Embodiment 4
Fructus Forsythiae 50g, Flos Lonicerae 80g, Folium Isatidis 90g, Rhizoma Belamcandae 30g, Radix Scutellariae 50g, Folium Microcoris paniculatae 40g, Semen Coicis 10g.
Preparation method and using method are as follows:
(1) takes by weighing the raw material that contains above-mentioned prescription weight;
(2) with claim in the step (1) each weight crude drug pulverize after, with 10 times of water yields medical material is soaked 30 minutes earlier after, extracts 2 times, 1.5 hours first time, 1 hour second time, merging filtrate also is condensed into 350ml.Concentrated filtrate adds dehydrated alcohol, makes that concentration of alcohol is 70% in the filtrate, filters, and filtrate is reclaimed ethanol by the method that steaming and decocting refluxes, and is concentrated into every 1ml and is equivalent to primary crude drug 1g, and cold preservation, filtration, fine straining, embedding, sterilization promptly are prepared into injection.
Drug use method of the present invention: porcine respiratory syndrome, intramuscular injection: each every 1kg body weight pig, injection 0.1 ~ 0.2ml, 2 times on the one, logotype 3 ~ 5 days.
Embodiment 5
Fructus Forsythiae 70g, Flos Lonicerae 90g, Folium Isatidis 100g, Rhizoma Belamcandae 40g, Radix Scutellariae 80g, Folium Microcoris paniculatae 50g, Semen Coicis 20g.
Preparation method and using method are as follows:
(1) takes by weighing the raw material that contains above-mentioned prescription weight;
(2) with claim in the step (1) each weight crude drug pulverize after, with 10 times of water yields the medical material immersion after 30 minutes, is extracted 2 times earlier, 1.5 hours for the first time, 1 hour for the second time, merging filtrate also was condensed into 450ml, and concentrated filtrate adds dehydrated alcohol, make that concentration of alcohol is 70% in the filtrate, filter, filtrate is reclaimed ethanol by the method that steaming and decocting refluxes, and is concentrated into every 1ml and is equivalent to primary crude drug 1g, filtration, embedding, sterilization promptly are prepared into oral liquid.
Drug use method of the present invention: the porcine respiratory syndrome, mix drink: every 1L water adds Chinese medicine 2ml of the present invention, freely drinks logotype 5 days.
Embodiment 6
Fructus Forsythiae 100g, Flos Lonicerae 150g, Folium Isatidis 120g, Rhizoma Belamcandae 50g, Radix Scutellariae 100g, Folium Microcoris paniculatae 80g, Semen Coicis 30g.
Preparation method and using method are as follows:
(1) takes by weighing the raw material that contains above-mentioned prescription weight;
(2) with claim in the step (1) each weight crude drug pulverize after, after with 10 times of water yields medical material being soaked 30 minutes earlier, extract 2 times, 1.5 hours for the first time, 1 hour for the second time, merging filtrate also was condensed into extractum, add appropriate amount of starch, magnesium stearate at last, granulation, tabletting, the every every 1g of 0.2g(is equivalent to crude drug in whole 1g), promptly be prepared into tablet.
Drug use method of the present invention: the porcine respiratory syndrome, oral: every day the 0.2g/ kg body weight, logotype 5 days.
In order to show the prevention effect of Chinese medicine of the present invention to the porcine respiratory syndrome, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of Chinese medicine of the present invention by the test example.
In November, 2009, there are 520 piglets on pig farm, Huidong County, Huizhou City, most of piglet feed intake decline occurs or does not eat, cough, rhinorrhea, dyspnea, ventral breathing aggravation, ear and limb end skin are blue, the abdominal part Intradermal has purple point, eye discharge increases, and conjunctivitis symptom etc. occurs, doubtful porcine respiratory syndrome.Select the piglet on this pig farm, the male and female pig all has, 40 ~ 50 ages in days, and body weight is 11.6 ~ 13.8kg, wherein 160, be divided into 8 groups, every group of 20 piglet is for examination.
Test grouping and administration: 1 ~ 6 group of test group, adopt embodiment 1 ~ 6 to be prepared medicine respectively, and respectively according to the using method medication of the embodiment of the invention 1 ~ 6.Infecting matched group is infected but the piglet of not administration; The normal healthy controls group is the healthy piglet that infects disease that do not have; All the other respectively organized logotype 7.Observation period is 15 days after the administration, and every pig is tested weighing of front and back and body condition observation.
The therapeutic evaluation index:
(1) mortality rate=dead piglet ÷ test piglet sum * 100%;
(2) cure rate=piglet is cured number ÷ test piglet sum * 100%;
(3) the effective piglet of effective percentage=treatment is counted ÷ test piglet sum * 100%;
(4) rate of body weight gain.The body weight of every pig during according to when beginning and off-test is calculated the increment of every pig, calculates the average weight gain and the standard deviation of every group of test pig then according to this.Rate of body weight gain ÷ normal healthy controls group rate of body weight gain * 100% of the relative weight gain rate=each medication group or infected group, wherein the normal healthy controls group is set at 100%.
Data analysis and processing: with SPSS 14.0 software data processings, wherein all with the Ka Shi check, the t check is adopted in weightening finish for mortality rate, cure rate, effective percentage, and statistical results see the following form.
Table 1 medicine of the present invention is added up porcine respiratory syndrome curative effect
| Group is inferior | Experimental animal head number/only | Mortality rate/% | Cure rate/% | Effective percentage/% | 15 days weightening finish/kg | Relative growth rate/% |
| Test group 1 | 20 | 15 | 70.00 | 80.00 | 4.53±1.40 | 70.1 |
| Test group 2 | 20 | 0 | 85.00 | 100.00 | 5.08±1.35 | 78.6 |
| Test group 3 | 20 | 0 | 90.00 | 100.00 | 5.40±1.42 | 84.2 |
| Test group 4 | 20 | 0 | 95.00 | 100.00 | 5.60±1.43 | 86.7 |
| Test group 5 | 20 | 0 | 90.00 | 100.00 | 5.36±1.40 | 83.0 |
| Test group 6 | 20 | 10 | 80.00 | 90.00 | 5.18±1.36 | 80.1 |
| Infect matched group | 20 | 50 | 20.00 | 30.00 | 1.78±1.26 | 27.6 |
| The normal healthy controls group | 20 | 0.00 | - | - | 6.46±1.48 | 100.00 |
Test result analysis:
(1 group is powder to 6 groups of medicine of the present invention, 2 groups is powder, 3 groups is granule, 4 groups is injection, 5 groups is oral liquid, 6 groups is tablet), test group 1 ~ 6 has significant difference (P＜0.01) with the infection matched group at mortality rate, cure rate, effective percentage, and 1 ~ 6 pair of porcine respiratory syndrome of test group all has significant curative effect; Test group 1 ~ 6 with infect matched group and have in the relative weight gain rate that difference extremely shows (P＜0.01) on the significant difference, but all be lower than the normal healthy controls group.
Claims (10)
1. a Chinese medicine composition of preventing and treating the porcine respiratory syndrome comprises following component and parts by weight: 10 ~ 100 parts of Fructus Forsythiaes, 30 ~ 150 parts of Flos Loniceraes, 20 ~ 120 parts of Folium Isatidiss, 10 ~ 50 parts of Rhizoma Belamcandae, 10 ~ 100 parts of Radix Scutellariaes, 10 ~ 80 parts of Folium Microcoris paniculataes, 5 ~ 40 parts of Semen Coiciss.
2. a Chinese medicine composition of preventing and treating the porcine respiratory syndrome comprises following component and parts by weight: 50 ~ 100 parts of Fructus Forsythiaes, 80 ~ 150 parts of Flos Loniceraes, 80 ~ 120 parts of Folium Isatidiss, 30 ~ 50 parts of Rhizoma Belamcandae, 50 ~ 100 parts of Radix Scutellariaes, 40 ~ 80 parts of Folium Microcoris paniculataes, 10 ~ 30 parts of Semen Coiciss.
3. a Chinese medicine composition of preventing and treating the porcine respiratory syndrome comprises following component and parts by weight: 80 parts of Fructus Forsythiaes, 100 parts of Flos Loniceraes, 90 parts of Folium Isatidiss, 40 parts of Rhizoma Belamcandae, 80 parts of Radix Scutellariaes, 60 parts of Folium Microcoris paniculataes, 15 parts of Semen Coiciss.
4. the application of Chinese medicine composition in control porcine respiratory syndrome of described any one control porcine respiratory syndrome of claim 1 ~ 3.
5. according to the application of Chinese medicine composition in control porcine respiratory syndrome of the described control porcine respiratory of claim 4 syndrome, the dosage form that it is characterized in that Chinese medicine composition is powder, tablet, powder, granule, oral liquid or injection.
6. application according to claim 5 is characterized in that preparation method may further comprise the steps when the Chinese medicine composition dosage form is powder:
(1) each medicine material is pulverized by the proportioning back of weighing, crossed 60 ~ 100 mesh sieves;
(2) step (1) products therefrom is added adjuvant or complementary composition commonly used in the pharmacy, conventional method is prepared into patent medicine;
When the Chinese medicine composition dosage form was powder, tablet, granule, oral liquid or injection, preparation method may further comprise the steps:
(1) each medicine material is weighed by proportioning;
(2) with extracting again after each medicine material mixing, filter, concentrate;
(3) will concentrate products therefrom and add adjuvant or complementary composition commonly used in the pharmacy, conventional method is prepared into patent medicine.
7. application according to claim 6 is characterized in that described being extracted as with 6 ~ 10 times of water gagings immersions 10 ~ 40 minutes, is heated to boiling, extracts twice, 1 ~ 2 hour for the first time, and 1 ~ 2 hour for the second time.
8. application according to claim 6 is characterized in that described adjuvant or complementary composition are starch, dextrin, sucrose, magnesium stearate.
9. application according to claim 6 is characterized in that when the Chinese medicine composition dosage form is powder, tablet, granule, oral liquid or injection, and simmer down to described in the step (2) is condensed into relative density in the time of 70 ℃ be 1.13 ~ 1.18 clear paste.
10. application according to claim 4 is characterized in that 3 ~ 5 days courses of treatment, and every day, using dosage was that oral dose is 0.1g ~ 0.3g/ kg body weight, and injection volume is 0.2 ~ 0.4ml/ kg body weight, logotype 3 ~ 7 days.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432215A (en) * | 2013-07-26 | 2013-12-11 | 清远容大生物工程有限公司 | Medicine used for preventing and treating high swine fever and preparation method thereof |
| CN104304787A (en) * | 2014-10-25 | 2015-01-28 | 黑龙江省农业科学院畜牧研究所 | Superfine powdery natural plant feed additive for preventing and controlling pig respiratory disease and preparation method of superfine powder natural plant feed additive |
| CN104435879A (en) * | 2014-11-15 | 2015-03-25 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicine composition for treating swine vesicular disease by virtue of internal and external administration |
| CN109350678A (en) * | 2018-12-28 | 2019-02-19 | 塔里木大学 | A kind of injection medicament for treating red deer respiratory tract infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401369A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Antiviral, antibacterial and antiinflammatory herbal injection for treating livestock and fowl infectious disease |
-
2010
- 2010-10-28 CN CN201010522446A patent/CN101961468B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401369A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Antiviral, antibacterial and antiinflammatory herbal injection for treating livestock and fowl infectious disease |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432215A (en) * | 2013-07-26 | 2013-12-11 | 清远容大生物工程有限公司 | Medicine used for preventing and treating high swine fever and preparation method thereof |
| CN103432215B (en) * | 2013-07-26 | 2016-03-02 | 广东容大生物股份有限公司 | A kind of medicine preventing and treating porcine hyperthermia and preparation method thereof |
| CN104304787A (en) * | 2014-10-25 | 2015-01-28 | 黑龙江省农业科学院畜牧研究所 | Superfine powdery natural plant feed additive for preventing and controlling pig respiratory disease and preparation method of superfine powder natural plant feed additive |
| CN104435879A (en) * | 2014-11-15 | 2015-03-25 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicine composition for treating swine vesicular disease by virtue of internal and external administration |
| CN109350678A (en) * | 2018-12-28 | 2019-02-19 | 塔里木大学 | A kind of injection medicament for treating red deer respiratory tract infection |
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Address after: 511500 construction 31, No. two, Guangdong hi tech Industrial Development Zone, Qingyuan Patentee after: GUANGDONG RONGDA BIOLOGY Co.,Ltd. Address before: 511517 biological medicine city of Qingyuan hi tech Development Zone, Guangdong Patentee before: QINGYUAN CONTAIN BIOENGINEERING Co.,Ltd. |
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Denomination of invention: Traditional Chinese medicine composition for prevention and treatment of porcine respiratory syndrome and its application Effective date of registration: 20200909 Granted publication date: 20111214 Pledgee: Bank of China Limited Qingyuan Branch Pledgor: GUANGDONG RONGDA BIOLOGY Co.,Ltd. Registration number: Y2020440000253 |
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Granted publication date: 20111214 Pledgee: Bank of China Limited Qingyuan Branch Pledgor: GUANGDONG RONGDA BIOLOGY Co.,Ltd. Registration number: Y2020440000253 |