CN104435879A - Traditional Chinese medicine composition for treating swine vesicular disease by virtue of internal and external administration - Google Patents
Traditional Chinese medicine composition for treating swine vesicular disease by virtue of internal and external administration Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention relates to a traditional Chinese medicine composition for treating a swine vesicular disease by virtue of internal and external administration. The traditional Chinese medicine composition is prepared from the following medicinal raw materials including honeysuckles, fructus forsythia, indigowoad leaves, cowherb seeds, semen coicis, dahurian patrinia herb, Chinese elder leaves, root barks of white mulberry, scutellaria baicalensis and pricklyash peels, can be simultaneously internally taken and externally applied and is prepared by the following steps: crushing the ten medicinal materials, and finely grinding into 40-100mesh to obtain traditional Chinese medicine powder; filling a gauze medicine bag with the traditional Chinese medicine powder, decocting in 5-15 times of water for 1-2h, and filtering to remove dregs of a decoction to obtain a medical solution for internal administration; and additionally taking the traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder and vaseline according to the ratio of 1:1 to prepare an ointment for external administration on an affected part. The traditional Chinese medicine composition for treating the swine vesicular disease has the efficacies of clearing away heat and toxic materials, resolving carbuncle, eliminating swelling, invigorating blood circulation to resolve carbuncle, and stopping pain and has the curative ratio of above 95 percent.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine composition of Orally taken and externally treatment SVD.
Background technology
SVD (SVD) is a kind of Acute exposure sexually transmitted disease caused by swine vesicular disease virus (SVDV), and this disease is popular strong, and sickness rate is high.Its principal character occurs that vesicle is for feature with coronet, frog, also vesicle occurs once in a while at lip, tongue, oral area, nose and abdominal part and nipple surrounding skin.
The pig of various age, kind all can infection morbidity, other artiodactyl domestic animals all not easy infections.Virus is mainly through skin, digestive tract, the respiratory tract intrusion pig body of breakage, and infection is mainly passed through contact, fed containing viral water from washing rice and butcher leftover bits and pieces, domestic animal transaction, means of transport etc.Primary disease all can occur throughout the year, but is more common in spring, season in winter two.At swinery highly dense, allocate and transport pig farm frequently, propagate very fast, sickness rate is also high, can reach 70%-80%, and when there is primary disease first, sickness rate can up to 100%.Typical case, light-duty and recessive type can be divided into according to symptom and the course of disease.Typical case's hydroa the earliest visible pig is walked lamely, and hard ground is walked then comparatively obvious, and normal back of a bow walking, have pain reaction, or sleeping ground does not play, the pig that physique is larger is more obvious.Body temperature is rising 2-4 DEG C generally.Damage generally occurs between coronet portion, frog, can fall ill by single hoof, also can many hoof morbidities.There is vesicle and ulceration in skin, and extends to bottom hoof, and what have loosens with coffin, even shells.Vesicle and Secondary cases ulcer also may occur on asoscope portion, oral epithelium, tongue and nipple.There is constitutional vesicle through the incubation period of 2-4 days in general contact infection, within 5-6 days, occurs Secondary cases vesicle.Newborn piglet generation primary disease mortality rate is high.General sick pig can return to normal condition in 3 weeks.If cause secondary bacterial infection, suppurate in local, the sleeping ground of disease pig can be caused not rise or in sitting position of dog gesture.Severe patient knee is creeped, loss of appetite, and spirit is depressed.Light-duty only have minority pig, at hoof, one, two vesicle occurs, and General Symptoms is slight, propagates slowly, and recover very fast, generally do not cause and discover.Recessive type does not show any clinical symptoms, but this boar may discharge virus, has very large danger to susceptible pig.Primary disease in the ordinary course of things, although fatality rate is low, mass-send infection, and pig is lost flesh in stadium seriously, if do not note treatment and nursing, also can cause pig death because of secondary infection because infectiousness is strong, propagate the rapid pig that easily causes.Therefore, take prophylactico-therapeutic measures timely and effectively to primary disease, it is very important for shortening the course of disease, early recovery sick pig and reduce in the sickness rate of primary disease.Main to put prevention first for this disease at present, strengthen Disinfectant management, there is no specific treatment medicine.
China's natural resources of Chinese medicinal materials enriches, and draws materials extensively.Developing the Chinese medicine of new water resistant bleb virus, is one of effective way solving SVD.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provide a kind of evident in efficacy, rapid-action, cure rate is high, can the Chinese medicine composition of Orally taken and externally simultaneously.
Another technical problem that the present invention will solve is: provide a kind of Orally taken and externally to treat the Chinese medicine formula of SVD.
Another technical problem that the present invention will solve is: the preparation method providing for oral administration of above-mentioned Chinese medicine composition and external application.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition of Orally taken and externally treatment SVD, is characterized in that: be prepared from by the raw material of following mass fraction: Flos Lonicerae 8-16 part, Fructus Forsythiae 12-16 part, Folium Isatidis 7-10 part, Semen Vaccariae 13-20 part, Semen Coicis 8-15 part, Herba Patriniae 5-10 part, Herba sambuci chinensis leaf 5-10 part, Cortex Mori 4-9 part, Radix Scutellariae 7-11 part, Fructus Zanthoxyli 6-10 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows: Flos Lonicerae 16 parts, Fructus Forsythiae 16 parts, Folium Isatidis 7 parts, Semen Vaccariae 13 parts, Semen Coicis 8 parts, 9 parts, Herba Patriniae 10 parts of, Herba sambuci chinensis leaves, Cortex Mori 4 parts, Radix Scutellariae 11 parts, Fructus Zanthoxyli 6 parts.
Further, this Chinese medicine composition can simultaneously Orally taken and externally.
Further, the preparation method of said composition is:
Flos Lonicerae 8-16 part, Fructus Forsythiae 12-16 part, Folium Isatidis 7-10 part, Semen Vaccariae 13-20 part, Semen Coicis 8-15 part, Herba Patriniae 5-10 part, Herba sambuci chinensis leaf 5-10 part, Cortex Mori 4-9 part, Radix Scutellariae 7-11 part, Fructus Zanthoxyli 6-10 part is taken by formula ratio.Above-mentioned Ten Herbs is pulverized, levigate to 40-100 order, obtain Chinese medicine powder.Chinese medicine powder is loaded gauze medicated bag, add 5-15 times amount decocting in water 1-2 hour, mistake filtering medicinal residues obtain medicinal liquid and take orally.Powder of separately getting it filled is mixed with into external application of ointment with vaseline in 1:1 ratio.
The advantage that the present invention has and good effect are:
(1) medicament of the present invention is based on theory of Chinese medical science, with organic conception and dialectical implementation principle understanding SVD.Grope through practice for many years, draft the relation between flavour of a drug dosage and compatibility, obtain the prescription of a pure Chinese medicine composition.There is heat-clearing and toxic substances removing, loose carbuncle detumescence, eliminating carbuncle of invigorating blood circulation, effect of reducing swelling and alleviating pain.Both this medicament Orally taken and externallies are combined, treating both the principal and secondary aspects of a disease, and have onset rapid, feature evident in efficacy, through clinical observation, cure rate can reach more than 95%.
(2) pure Chinese crude drug is all, environmental protection, nontoxic pollution-free selected by the present invention.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind and heat pathogens;
Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens;
Folium Isatidis: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing;
Semen Vaccariae: promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle;
Semen Coicis: promoting diuresis to eliminate damp pathogen, spleen invigorating, eliminating impediment, clearing away heat and discharging pus;
Herba Patriniae: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing;
Herba sambuci chinensis leaf: heat-clearing and toxic substances removing, anti-inflammation, expelling wind and removing dampness;
Cortex Mori: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema;
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication;
Fructus Zanthoxyli: heat clearing and damp drying, killing parasites for relieving itching.
Among formula, Flos Lonicerae is sweet cold, heat-clearing and toxic substances removing, and loose carbuncle detumescence, for controlling the key medicine of all abscess of internal organ external carbuncle; Fructus Forsythiae bitter cold, can separate sore, and the carbuncle that can dissipate again knot is poly-, is persons particularly liable to develop skin infection's panacea; Folium Isatidis heat-clearing and toxic substances removing, controls carbuncle and ulcer and swells and ache; The pungent loose hardship of Herba Patriniae is let out cold and cool, gets final product heat-clearing and toxic substances removing, again can eliminating carbuncle evacuation of pus, and Flos Lonicerae, Fructus Forsythiae, Folium Isatidis and Herba Patriniae are the medicine of heat-clearing and toxic substances removing, and compatibility uses, and can control carbuncle sore tumefacting virus, and no matter having burst, it is all effective not burst.There is again Semen Coicis promoting diuresis to eliminate damp pathogen, removing pus and relieving carbuncle.Cortex Mori regulating fluid apssage inducing diuresis to remove edema.Semen Vaccariae is good at promoting blood circulation, promoting blood circulation to restore menstrual flow, eliminating carbuncle of invigorating blood circulation, effect of reducing swelling and alleviating pain.Herba sambuci chinensis leaf heat-clearing and toxic substances removing, controls sore swollen toxin.Radix Scutellariae has the effect of clearing away heat-fire removing toxic substances, availablely controls the flourishing carbuncle sore tumefacting virus of fire-toxin.Fructus Zanthoxyli heat clearing and damp drying.Above-mentioned ten taste medicines share, and have heat-clearing and toxic substances removing, loose carbuncle detumescence, eliminating carbuncle of invigorating blood circulation, effect of reducing swelling and alleviating pain.Orally taken and externally, treating both the principal and secondary aspects of a disease.
Detailed description of the invention
Be further described the present invention below by specific embodiment, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A Chinese medicine composition for Orally taken and externally treatment SVD, the parts by weight of each raw material are as follows: Flos Lonicerae 16 parts, Fructus Forsythiae 16 parts, Folium Isatidis 7 parts, Semen Vaccariae 13 parts, Semen Coicis 8 parts, 9 parts, Herba Patriniae 10 parts of, Herba sambuci chinensis leaves, Cortex Mori 4 parts, Radix Scutellariae 11 parts, Fructus Zanthoxyli 6 parts are prepared from.Its preparation method is: take above-mentioned Ten Herbs by weight, pulverize, levigate, cross 80 mesh sieves, obtain Chinese medicine powder.Chinese medicine powder is loaded gauze medicated bag, add water in the ratio of 100g:1000ml, boil 1 hour, filter cleaner obtains medicinal liquid, stay do for oral administration.Powder of separately getting it filled is mixed with into ointment with vaseline in the ratio of 1:1, stays and does external application.
Embodiment 2
A Chinese medicine composition for Orally taken and externally treatment SVD, the parts by weight of each raw material are as follows: Flos Lonicerae 10 parts, Fructus Forsythiae 15 parts, Folium Isatidis 8 parts, Semen Vaccariae 20 parts, Semen Coicis 15 parts, 5 parts, Herba Patriniae 5 parts of, Herba sambuci chinensis leaves, Cortex Mori 6 parts, Radix Scutellariae 7 parts, Fructus Zanthoxyli 9 parts are prepared from.Its preparation method is: take above-mentioned Ten Herbs by weight, pulverize, levigate, cross 80 mesh sieves, obtain Chinese medicine powder.Chinese medicine powder is loaded gauze medicated bag, add water in the ratio of 100g:1000ml, boil 1 hour, filter cleaner obtains medicinal liquid, stay do for oral administration.Powder of separately getting it filled is mixed with into ointment with vaseline in the ratio of 1:1, stays and does external application.
Embodiment 3
A Chinese medicine composition for Orally taken and externally treatment SVD, the parts by weight of each raw material are as follows: Flos Lonicerae 8 parts, Fructus Forsythiae 12 parts, Folium Isatidis 10 parts, Semen Vaccariae 15 parts, Semen Coicis 10 parts, 10 parts, Herba Patriniae 8 parts of, Herba sambuci chinensis leaves, Cortex Mori 9 parts, Radix Scutellariae 8 parts, Fructus Zanthoxyli 10 parts are prepared from.Its preparation method is: take above-mentioned Ten Herbs by weight, pulverize, levigate, cross 80 mesh sieves, obtain Chinese medicine powder.Chinese medicine powder is loaded gauze medicated bag, add water in the ratio of 100g:1000ml, boil 1 hour, filter cleaner obtains medicinal liquid, stay do for oral administration.Powder of separately getting it filled is mixed with into ointment with vaseline in the ratio of 1:1, stays and does external application.
Clinical trial
Experiment 1
The feeder pig 1 that Guizhou Province raiser raises, morbidity disease is seen: body temperature 41.4 DEG C, hind leg dysstasia, and row of crossing mountains, coronet swelling, have the large vesicle of Semen Glycines between toe and fester, nose dish also has vesicle, appetite, change of spirit are little.After one day also there is swelling in affected pig forelimb, and hind leg coffin comes off, drenched with blood, and infected a contiguous packing sow, the same feeder pig of symptom, but breast also has vesicle.First visit is SVD.Then colony house is thoroughly cleaned clean, spray with the Caustic soda of 2%-5% concentration.Affected part is rinsed subsequently with 0.1% potassium permanganate water, and the ointment obtained by external application embodiment 1, every day 2 times, be used in conjunction 7 days.Decoction simultaneously obtained by gavage embodiment 1, each 200ml, once-a-day, is used in conjunction 7 days.Further consultation after 7 days, packing sow is fully recovered, and feeder pig walks hard place more afterwards and slightly to cross mountains row because coffin comes off.Experiment 1 proves that Orally taken and externally combined treatment, onset is rapid, and curative effect is obvious by the product treatment SVD obtained by embodiment 1.
Experiment 2
Pig farm, Hebei province, originally have 6 pigs to occur walking lamely, body temperature is increased between 40-42 DEG C.The coronet finding the main toe of disease pig and secondary toe on inspection there is size as Semen Glycines or Semen Viciae fabae, the vesicle obviously protruded.Vesicle is broken very soon, forms ulcer.Very fast pig farm jumpbogroup infects, and sick hog snout dish, lip and tongue also shows vesicle, also has vesicle near sow nipple.The person of being in a bad way occurs that spirit is depressed, and loss of appetite, does not rise sleepingly.Tentative diagnosis is SVD.Sick pig is divided into 2 groups at random.Decoction wherein obtained by one group 80 embodiments 1 for oral administration, each 200ml, once-a-day; Affected part 0.1% potassium permanganate water rinses simultaneously, then smears the ointment obtained by embodiment 1, twice on the one.Be used in conjunction 7 days.Medication started incrustation in ulcer place after 3 days, and be almost recovered after 7 days, cure rate is 96.3%, and effective percentage is 100%, and occurs without secondary infection.Another organizes 77 intramuscular injection moroxydine 10ml, 2, qd.1% Gentian Violet is smeared in affected part.Be used in conjunction 7 days.Medication started incrustation in affected part after 5 days, and jumpbogroup recovery from illness after 7 days, cure rate is 88.3%, and effective percentage is 93.5%.Specific experiment data are in table 1.
Table 1 liang group Drug therapy SVD comparitive study
| Group | Number of cases (head) | Cure rate | Effective percentage | Mortality rate |
| Chinese drug-treated group | 80 | 77(96.3％) | 80(100％) | Nothing |
| Western medicine group | 77 | 68(88.3％) | 72(93.5％) | Nothing |
The data that analysis design mothod 2 obtains, no matter treatment by Chinese herbs group is from onset time, or from cure rate and effective percentage, is all better than Western medicine group.Illustrate that the Therapeutic Method onset adopting internal and external medicine of the present invention is rapid, curative effect is obvious.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. the Chinese medicine composition of an Orally taken and externally treatment SVD, it is characterized in that, be prepared from by the raw material of following mass fraction: Flos Lonicerae 8-16 part, Fructus Forsythiae 12-16 part, Folium Isatidis 7-10 part, Semen Vaccariae 13-20 part, Semen Coicis 8-15 part, Herba Patriniae 5-10 part, Herba sambuci chinensis leaf 5-10 part, Cortex Mori 4-9 part, Radix Scutellariae 7-11 part, Fructus Zanthoxyli 6-10 part.
2. the Chinese medicine composition of Orally taken and externally treatment SVD according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Flos Lonicerae 16 parts, Fructus Forsythiae 16 parts, Folium Isatidis 7 parts, Semen Vaccariae 13 parts, Semen Coicis 8 parts, 9 parts, Herba Patriniae 10 parts of, Herba sambuci chinensis leaves, Cortex Mori 4 parts, Radix Scutellariae 11 parts, Fructus Zanthoxyli 6 parts.
3. the Chinese medicine composition of Orally taken and externally according to claim 3 treatment SVD, is characterized in that: preparation method is: take above-mentioned ten taste medicines by formula ratio, pulverizes, levigate to 40-100 order, obtains Chinese medicine powder.Chinese medicine powder is loaded gauze medicated bag, add 5-15 times amount decocting in water 1-2 hour, cross filtering medicinal residues and obtain medicinal liquid.Powder of separately getting it filled is mixed with into ointment with vaseline in 1:1 ratio.
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| CN201410649348.3A Pending CN104435879A (en) | 2014-11-15 | 2014-11-15 | Traditional Chinese medicine composition for treating swine vesicular disease by virtue of internal and external administration |
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| CN (1) | CN104435879A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060188561A1 (en) * | 1996-01-22 | 2006-08-24 | Pliva, Inc. (Formerly Known As Sidmak Laboratories, Inc.) | Pharmaceutical compositions for lipophilic drugs |
| CN101961468A (en) * | 2010-10-28 | 2011-02-02 | 清远容大生物工程有限公司 | Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof |
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- 2014-11-15 CN CN201410649348.3A patent/CN104435879A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060188561A1 (en) * | 1996-01-22 | 2006-08-24 | Pliva, Inc. (Formerly Known As Sidmak Laboratories, Inc.) | Pharmaceutical compositions for lipophilic drugs |
| CN101961468A (en) * | 2010-10-28 | 2011-02-02 | 清远容大生物工程有限公司 | Traditional Chinese medicinal composition for preventing and treating porcine respiratory syndrome and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 吴大真等: "《名中医皮肤科绝技良方》", 31 January 2009 * |
| 马文辉: "《刘绍武讲评《伤寒杂病论》》", 31 March 2010 * |
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