CN103933128B - Pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof - Google Patents
Pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof Download PDFInfo
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Abstract
The invention discloses pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof, belong to the field of Chinese medicines.This pharmaceutical composition is the crude drug such as Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, Radix Platycodonis, after pharmaceutical drying, and makes powder.This pharmaceutical composition has effect of heat-clearing and toxic substances removing, purging fire and cooling blood, lung qi dispersing Zhichuan, inhibitory anti-virus, be mainly used in treatment infectious disease and cause the symptoms such as morbidity chicken high heat, watery nasal discharge, nasal obstruction, cough, appetite decline, hypoimmunity, more effective to respiratory tract, intestinal infection symptom, regular use has certain preventive effect to infectious disease, and do not affect laying rate, also can improve the sub-health status of birds.Product reasonable recipe of the present invention, technique is simple, and cost is low, has no side effect, safe and effective.
Description
Technical field
The invention belongs to poultry disease treatment technology field, be specifically related to pharmaceutical composition of a kind of heat-clearing and toxic substances removing and preparation method thereof.
Background technology
Method of dissipating heat and detoxifying, namely every use has the medicine of removing summer-heat pyretic toxicity effect and reaches the method for removing summer-heat pyretic toxicity object, is exactly method of dissipating heat and detoxifying.Heat-clearing and toxic substances removing medicine comprises dividing of narrow and broad sense.The heat and toxic materials clearing away medicine of narrow sense only refers to the medicine of the primary treatment such as Flos Lonicerae, Fructus Forsythiae carbuncle furuncle, and sensu lato heat and toxic materials clearing away medicine then refers to that all have the antipyretic of Detoxication.As being classified as the Rhizoma Coptidis, Radix Scutellariae etc. of heat clearing and dampness removing medicine by " conventional Chinese medicine ", except there is heat clearing and damp drying effect, also has very strong eliminating fire and detoxication effect; And for the Fructus Gardeniae, Fel Ursi etc. of clearing away heat-fire, for the Cornu rhinocerotis, Radix Arnebiae (Radix Lithospermi), Calculus Bovis etc. of clearing away heat and cooling blood, for the Semen phaseoli radiati, Artemisia annua L. etc. of clearing away summer-heat, except there is respective speciality, be also no lack of the merit of removing toxic substances.Therefore, current epidemic febrile disease is said heat and toxic materials clearing away medicine clinically, in fact then refers to sensu lato heat and toxic materials clearing away medicine.
In traditional Chinese medical science differential diagnosis in terms of eight principles, cold and heat card is two importances wherein, and the pattern of syndrome that heat syndrome is common clinically especially.The mechanism forming heat syndrome has a lot, if deficiency of vital energy heat-dissipating, excess of YANG bringing about heat syndrome, heat formation from yin deficiency, excessive YIN keeping YANG externally are in outer then warm etc.; Heat syndrome pattern of syndrome has excess-heat, deficiency-heat, real heat with pseudo-cold, heat in the upper and cold in the lower etc.; Therapeutic Method has clearing away heat-fire, cooling upper-JIAO and warming lower-JIAO, clearing away interior-heat, nourishing YIN and clearing away heat etc.Acute inflammation is the main manifestations of heat syndrome, is again the important pathological process of acute infectious diseases.Inflammation be there is vascular system life body to the defense reaction of a kind of complexity that damage factor occurs.In every case the factor of tissue and cell injury can be caused to cause tissue inflammation, cause the kind of the factor of inflammation to have a lot.Wherein mainly comprise this five class of the physical property factor, biological factors, the chemical factor, tissue necrosis and allergy.The basic pathology change procedure of inflammation mainly comprise rotten, ooze out and hypertrophy.The early stage pathological changes of general inflammation is mainly based on rotten and ooze out, and late inflammatory pathological changes is then based on hypertrophy.
Under the effect of pyrogen, make body temperature set point increase and then the thermoregulation that causes raises, be called heating.In various diseases progression, heating is a kind of common symptom, especially infective disease.Compound recipe based on Flos Lonicerae has SHUANGHUANGLIAN KOUFUYE, SHUANGHUANGLIAN ZHUSHEYE, YINHUANG ZHUSHEYE, Lonicerae and Forsythiae Powder etc., be usually used in treating affection due to external wind and heat, epidemic febrile disease from the beginning of, on modern medicine, i.e. the affection due to external wind and heat or warm from the beginning of person such as respiratory tract infection, acute bronchitis, acute, chronic pharyngitis, influenza, parotitis.Compound recipe based on Radix Isatidis has Radix Isatidis granule, Radix Isatidis injection etc.Be usually used in treating epidemic febrile disease, wind heat exterior syndrome, be equivalent to the heresy person that attacks table of the upper respiratory tract infection of modern medicine, influenza, parotitis, acute bronchitis, acute, chronic pharyngitis Isothermal Hot.
There is no the heat-clearing and toxic substances removing compound medicine of specially good effect at present.To infectious disease clinically by adopting Western medicine to carry out symptomatic treatment, western medicine only can reduce death, and disease course is extended, but is difficult to reach good therapeutic effect.Some raiser, in order to prevent secondary infection, uses antibiotic for a long time in a large number, and antibiotic drug residue of feeding is heavier, brings potential safety hazard to food.Study a kind of inhibitory anti-virus, not easily produce drug resistance, medicine that toxic and side effects is little, be veterinary's circle urgent problem, Study and Development utilizes China's Chinese herbal medicine resource to reach heat-clearing and toxic substances removing object, has caused the very big attention of domestic and international experts and scholars.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition of effect with heat-clearing and toxic substances removing, lung qi dispersing Zhichuan, purging fire and cooling blood, inhibitory anti-virus, i.e. good, the pure Chinese medicinal preparation of the heat-clearing and toxic substances removing for the treatment of infectious disease that has no side effect of a kind of heat-clearing and toxic substances removing, short treating period, therapeutic effect.
Pharmaceutical composition of the present invention crude drug composition and proportioning as follows:
Flos Lonicerae 5 ~ 45 weight portion, Radix Isatidis 5 ~ 55 weight portion, Radix Scutellariae 5 ~ 55 weight portion, Fructus Forsythiae 5 ~ 50 weight portion, Radix Bupleuri 5 ~ 60 weight portion, Radix Platycodonis 5 ~ 30 weight portion, Radix Glycyrrhizae 1 ~ 10 weight portion.
The crude drug composition optimum proportioning of pharmaceutical composition of the present invention is (by weight):
Flos Lonicerae 15 weight portion, Radix Isatidis 20 weight portion, Radix Scutellariae 20 weight portion, Fructus Forsythiae 15 weight portion, Radix Bupleuri 15 weight portion, Radix Platycodonis 10 weight portion, Radix Glycyrrhizae 5 weight portion.
Medicine of the present invention can be prepared into powder, and preparation method is as follows: Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae are shattered into fine powder respectively; The fine powder shattered is crossed 100 ~ 200 mesh sieves respectively; After each fine drug powder drying, press proportion weigh; Finally by each fine drug powder mix homogeneously, to obtain final product.
The adjuvant added in pharmaceutics also can be selected in above-mentioned powder; Such as, during starch, sucrose, dextrin, lactose, micropowder silica gel, aspa are sweet etc. one or more.
Pharmaceutical composition of the present invention is mainly used in the treatment of poultry heat-clearing and toxic substances removing;
Above-mentioned poultry is preferably laying hen.
Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, lung qi dispersing Zhichuan, purging fire and cooling blood, inhibitory anti-virus, can kill pathogen fast, lasting medicine, not easily produces drug resistance strain.Improve immunity of organisms, induction body produces interferon, improves cytophagous phagocytic function.Relieving diarrhea with astringents, bactericidal antiphlogistic, reparation intestinal, the functions such as appetite strengthening.The present invention, by the method for the treatment of of heat-clearing and toxic substances removing, lung qi dispersing Zhichuan, have received satisfied curative effect to the prevention and therapy of the disease such as respiratory tract infection, intestinal infection in clinical trial.Processing technology of the present invention is simple, and cost is low.
Detailed description of the invention
The present invention is theoretical according to Chinese medicine and pharmacy, utilizes the property of medicine of medical herbs uniqueness, and employing Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae are made according to the requirement of certain compatibility.In the present invention, Flos Lonicerae is sweet cold, has heat-clearing and toxic substances removing, controls effect of pyretic toxicity dysentery; Radix Isatidis has the effect of heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving, cures mainly various pyretic toxicity, pestilence, skin ulcer general edema with yellowish skin poison etc.; Radix Scutellariae has the effect sending out heat clearing and damp drying, eliminating fire and detoxication, for diarrhea due to damp-heat, hygropyrexia etc.; Fructus Forsythiae has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Radix Bupleuri has effect of reducing fever by reconciliation, depressed liver-energy dispersing and QI regulating, elevate a turnable ladder yang-energy; Radix Platycodonis has that lung qi dispersing eliminates the phlegm, effect of evacuation of pus detumescence, cures mainly affection of exogenous wind-cold or wind heat is cough caused, laryngopharynx swelling and pain etc.; Radix Glycyrrhizae invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relax the property of medicine.This seven medicine share have heat-clearing and toxic substances removing, purging fire and cooling blood, inhibitory anti-virus potent, clinical in heat-clearing and toxic substances removing Be very effective.And proportioning of the present invention can ensure the stable of laying rate while treatment laying hen heat symptom-complex.
Illustrate with specific embodiment more below, but following embodiment does not only limit the present invention for illustration of the present invention.
Embodiment 1:
Prescription: Flos Lonicerae 15g, Radix Isatidis 20g, Radix Scutellariae 20g, Fructus Forsythiae 15g, Radix Bupleuri 15g Radix Platycodonis 10g, Radix Glycyrrhizae 5g.
Method for making: Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae in prescription are shattered into fine powder respectively; The fine powder shattered is crossed 100 mesh sieves respectively; After each fine drug powder drying, press proportion weigh; Finally by each fine drug powder mix homogeneously, to obtain final product.
Embodiment 2:
Prescription: Flos Lonicerae 180g Radix Isatidis 150g Radix Scutellariae 150g Fructus Forsythiae 120g
Radix Bupleuri 120g Radix Platycodonis 100g Radix Glycyrrhizae 50g
Method for making: Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae in prescription are shattered into fine powder respectively; The fine powder shattered is crossed 100 mesh sieves respectively; After each fine drug powder drying, press proportion weigh; Finally by each fine drug powder mix homogeneously, to obtain final product.
Embodiment 3:
Certain chicken farm raises table hens about 8742, and chicken, during 30 days ages, respiratory tract infection occurs.Morbidity chicken totally 2600.
Morbidity chicken is divided into two groups at random, gives the made powder medication of the embodiment of the present invention 1, scheme for one group: mixed drink, after soaking 20min by appropriate warm water, medicinal liquid is blended in 1/3 or 1/4 water of whole day amount of drinking water to concentrate and drinks, medicinal residues spice, every day 2 times, successive administration 5 days; Give seven for two groups to relieve internal heat clearly granule (main component has the Radix Astragali, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis), Qingdao Zhongren Pharmaceutical Co.Ltd. produces.Scheme: mixed drink, every 1kg is watered 2000kg, successive administration 5 days; Two kinds of therapeutic schemes all assist the measures such as cleaning, cleaning, sterilization, isolation.
Sick chicken clinical symptoms: sick chicken ataxia, sneeze, cough, snore, stridulates, and eye conjunctiva flushing, drops tears, stream nose liquid, and dyspnea, feed intake declines, and laying rate declines, and has broken shell, soft-shelled egg etc.Main pathological change: nasal cavity, accumulate exudate under socket of the eye in hole and cause eyelid swelled, conjunctivitis, nasal cavity has mucus, and annulus trachealis is hemorrhage, and tracheal strips has muddy blood effusion; Air bag is muddy, and serious airbag wall is yellow cheese thing film.After administration, symptom judges:
Cure: chicken normal diet, drinking-water, energetic, one's eyes drop millstones, without diarrhoea and respiratory symptom, laying rate recovers normal, without broken shell, soft-shelled egg.
Effective: chicken normal diet, drinking-water, do not cough, without diarrhoea.
Add up two groups of effects respectively, in table 1.
The efficacy result of each medication group of table 1
Visible, evident in efficacy compared with matched group of medicine group of the present invention.
Embodiment 4:
Shandong plant raises laying hen 4000, wherein laying hen 500 the burst respiratory tract infection of 260 ages in days, and it is depressed that clinical symptoms shows as spirit, high heat, and feather is fluffy and disorderly, cough, watery nasal discharge, and feed intake declines, and egg production declines, and produces broken shell, soft-shelled egg etc.The powder treatment that Example 2 is made, scheme: all chicken isolation, spice is fed, every 10g spice 1kg feedstuff, administration 5 days, owing to finding in time, this morbidity is only broadcast poultry is handed down from the older generations of the family, do not infect people, except 62 sick chicken deaths, other morbidity chickens are all without infection symptoms, and egg production increases, laying rate is significantly improved, and total effective rate is 87.6%.The chicken do not fallen ill carries out prophylactic, every 5g spice 1kg feedstuff, continuous use 3 days, administration, after 3 days, does not find new cases, and laying rate is normal, do not find to produce broken shell, soft-shelled egg chicken, illustrate that product of the present invention is remarkable to the therapeutic effect of respiratory tract infection, and do not affect laying rate, prophylactic effectively can increase immunity and the resistance against diseases of animal body.
Embodiment 5:
Henan chicken raising factory has broiler 2452, this cultivation factory raise poultry several years, occurs once there being morbidity chicken to the intestinal infection multiple phase.For a change this situation, raiser carries out a prophylactic in advance to improve the effect of immunity before intestinal infection.The powder medication that Example 2 is made, scheme: after soaking 20min by appropriate warm water, medicinal liquid is blended in 1/3 or 1/4 water of whole day amount of drinking water to concentrate and drinks, and medicinal residues spice, every day 2 times, is used in conjunction 3 days.This chicken house there is no intestinal infection in the intestinal infection multiple phase and occurs, and laying rate is normal, successfully plays preventive effect.
Embodiment 6:
10000 AA broiler are raised in chicken farm, Weifang, Shandong, occur that depressed, drowsiness, the feed intake of spirit reduces at 20 ages in days, degradation symptom under egg production, add that Changes in weather is indefinite, in succession there is the respiratory symptoms such as high heat, watery nasal discharge, sneeze, cough, dyspnea in morbidity chicken, poultry is main in order to alleviate occurred symptom, prevent the state of an illness from further developing, the pre-medicine that uses is treated.The powder medication that Example 1 is made, after soaking 20min by appropriate warm water, medicinal liquid is blended in 1/3 or 1/4 water of whole day amount of drinking water to concentrate and drinks, and every day 2 times, be used in conjunction 5 days, initial dose is multiplicable.After medication treatment, the corresponding disappearance of respiratory symptom of sick chicken, laying rate is normal, and the spiritual appetite of sick chicken recovers good, the state of an illness is well controlled, and illustrates that product of the present invention effectively can alleviate the respiratory symptom of birds, and not affecting laying rate, therapeutic effect is better.
Claims (7)
1. be used for the treatment of the pharmaceutical composition of laying hen heat-clearing and toxic substances removing, it is characterized in that described pharmaceutical composition is made up of following crude drug:
2. pharmaceutical composition as claimed in claim 1, is characterized in that described pharmaceutical composition is made up of following crude drug:
3. for a preparation for heat-clearing and toxic substances removing, it is characterized in that, described preparation thing is powder, and its preparation method is as follows:
Flos Lonicerae in claim 1 or 2, Radix Isatidis, Radix Scutellariae, Fructus Forsythiae, Radix Bupleuri, Radix Platycodonis, Radix Glycyrrhizae are shattered into fine powder respectively; The fine powder shattered is crossed 100 ~ 200 mesh sieves respectively; After each fine drug powder drying, mix homogeneously is made.
4. preparation as claimed in claim 3, is characterized in that, be also added with the adjuvant in pharmaceutics.
5. preparation as claimed in claim 4, it is characterized in that described adjuvant be starch, sucrose, dextrin, lactose, micropowder silica gel, aspa sweet etc. in one or more.
6. the application in poultry heat-clearing and toxic substances removing goods prepared by preparation according to claim 3.
7. be used for the treatment of goods for laying hen heat-clearing and toxic substances removing, it is characterized in that, described goods include preparation according to claim 3.
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| CN108498655B (en) * | 2018-06-04 | 2021-02-02 | 湖南中嘉药物开发有限公司 | Lanjin oral liquid for clearing heat and removing toxicity and preparation method thereof |
| CN108904592A (en) * | 2018-07-03 | 2018-11-30 | 淄博维希尔生物技术有限公司 | A kind of pure Chinese medicine antivirus veterinary herbal mixture concentrate and oral solution and preparation method thereof |
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| CN108653574B (en) * | 2018-08-13 | 2021-07-20 | 三株福尔制药有限公司 | Probiotic fermented antiviral composition and preparation method and application thereof |
| CN112022975A (en) * | 2020-09-21 | 2020-12-04 | 成都温江众氏陈中草药销售有限公司 | Antiviral traditional Chinese medicine composition |
| CN114366770A (en) * | 2020-10-14 | 2022-04-19 | 洛阳瑞华动物保健品有限公司 | Preparation method of Qiqing Baidu granules |
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