CN102526356B - Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry - Google Patents
Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry Download PDFInfo
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- CN102526356B CN102526356B CN2012100660604A CN201210066060A CN102526356B CN 102526356 B CN102526356 B CN 102526356B CN 2012100660604 A CN2012100660604 A CN 2012100660604A CN 201210066060 A CN201210066060 A CN 201210066060A CN 102526356 B CN102526356 B CN 102526356B
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Abstract
The invention relates to a traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry. 30-50 parts of cortex moutan, 30-50 parts of scutellaria, 20-40 parts of folium isatidis, 15-30 parts of rhizome of rehmannia and 15-30 parts of herba cepbalanoplosis segeti are prepared into the traditional Chinese medicine compound. The traditional Chinese medicine compound has the effects of clearing Ying heat and cooling blood as well as expelling plague and relieving internal heat. The traditional Chinese medicine compound is used for treating the syndromes of pathogenic heat transferring Ying and heat invading blood of the poultry, such as chicken, ducks, and the like, and has the advantages that the effect is exact, no toxic side-effect exists, no medicine is maintained, and the like.
Description
Technical field
The invention belongs to veterinary drug preparation production and application, relate to a kind of Chinese prescription, especially relate to a kind of Chinese medicine composition for the poultry clearing away heat from YING and blood systems.
Background technology
Along with the expansion of China's poultry farming scale, infectious disease more and more becomes the key factor of restriction fanning economics.Simultaneously, along with the concern of people to the poultry prod food safety, herbal medicine more and more comes into one's own in the clinical application of fowl diseases.
The most infectious diseases of poultry are belonged to " distemper card " Chinese veterinarian, think due to the animal body being invaded by exogenous pathogen.At first exopathogen is invaded lung and is defended, if can not clean up in time, or the exopathogen virulence is stronger, rapidly to the nutrient blood change of disease." the distemper card " of the clinical normal generation of fowl diseases in recent years, main manifestations are the respiratory tract infection occurred rapidly, and full group's lethargy, ingest, drink water and decline to a great extent then; Cut open the visible air bag muddiness of inspection, respiratory tract, digestive tract hemorrhage, thymus, kidney swelling, hemorrhage.Such epidemic disease infective agent complexity, conventional antimicrobial agents control generally is difficult to produce effects, and the morbidity poultry is many because of dehydration, organ failure's death, brings massive losses to poultry farming.According to Chinese veterinarian's QI and blood battalion, defend dialectically, in conjunction with generation and the epidemic characteristic of this disease and cut open the inspection pathological change, this disease belongs to pathogenic heat, and to join the army, consume wound battalion cloudy, and distemper accumulates the performance of blood, intense heat in both QI and blood systems.The Therapeutic Principle should the clearing heat in YING system removing toxic substances be main, is aided with diathermanous yin nourishing.
The Chinese prescription application of clinical existing " eliminating pestilence and relieving toxicity " class of fowl diseases at present.Yet, still there are the following problems: the infection that the Chinese prescription of 1. reporting causes for certain pathogen mostly in the clinical application of fowl diseases for these herbal medicines, the marrow that this principles of formulating prescriptions have deviated from Chinese medicine be to nurse one's health animal body function but not for the ultimate principle of pathogen, on the other hand, mostly the generation that also is not suitable for current fowl diseases is the clinical practice of several pathogen mixed infection.2. the Chinese prescription complexity of reporting, and comprise the higher Chinese crude drugs of price such as Cornu Bubali, Flos Lonicerae, Radix Bupleuri, Fructus Forsythiae more, cause medicament composing prescription on the high side, limited Chinese medicine in the clinical application of fowl diseases.3. the current Chinese prescription that is applied to fowl diseases clinical " heat-clearing and toxic substances removing " of reporting, be mainly used in heat-clearing and toxic substances removing, purging fire and cooling blood, for pathogenic heat, enter all diseases of blood good therapeutic effect is arranged, but current fowl diseases clinical popular " distemper card ", pathogenic factor is rapidly to battalion's minute change of disease, heat clearing away during treatment and do not pay close attention to clearing heat in YING system, be difficult to receive produce effects.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to, by prescription again after the Chinese medicine pharmacology is studied, provides a kind of Chinese medicine composition for the poultry clearing away heat from YING and blood systems.Said composition is as a kind of pure Chinese medicinal preparation, and to the respiratory tract mixed infection of effective control poultry " distemper card ", and in minimizing poultry farming process, use, the minimizing drug residue of antibacterials is significant.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions:
A kind of Chinese medicine composition for the poultry clearing away heat from YING and blood systems, this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Cortex Moutan 30-50 part, Radix Scutellariae 30-50 part, Folium Isatidis 20-40 part, Radix Rehmanniae 15-30 part, Herba Cirsii 15-30 part.
In a preferred embodiment of the present invention, described Chinese medicine composition for the poultry clearing away heat from YING and blood systems, formed by the active fraction preparation of following weight portion: 30 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 15 parts, the Radix Rehmanniae, 10 parts of Herba Cirsiis.
In another preferred embodiment of the present invention, described Chinese medicine composition for the poultry clearing away heat from YING and blood systems, formed by the active fraction preparation of following weight portion: 50 parts of Cortex Moutans, 45 parts of Radix Scutellariaes, 40 parts of Folium Isatidiss, 30 parts, the Radix Rehmanniae, 30 parts of Herba Cirsiis.
In another preferred embodiment of the present invention, described Chinese medicine composition for the poultry clearing away heat from YING and blood systems, formed by the active fraction preparation of following weight portion: 45 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 30 parts, the Radix Rehmanniae, 20 parts of Herba Cirsiis.
The present invention presses the Chinese powder medicine of the general production technology manufacture of veterinary drug powder, feeds or boiled water punching is stewing, the poultry of feeding after decocting by spice, prevents and treats for the clearing away heat from YING and blood systems of poultry " distemper card ".
The present invention becomes oral liquid by the general production technology manufacture of veterinary drug oral liquid, also can be according to the granule of veterinary drug granule technological process of production manufacture.
Therefore, described Chinese medicine composition for the poultry clearing away heat from YING and blood systems, it is powder, granule or oral liquid.Described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
According to the Chinese medicine Historical Data Data About, above-mentioned 5 flavor Chinese crude drugs have following pharmacologically active and function cures mainly:
Cortex Moutan: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; The rheumatism pyretic arthralgia.Be selected from the dry root bark of ranunculaceae peony.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Select the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.
Folium Isatidis: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Be selected from leaf or the branch and leaf of cruciferae isatis.
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing, promote the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, send out the speckle dermexanthesis.Be selected from the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch., also claim Radix Rehmanniae.
Herba Cirsii: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, to spit blood, hematuria, have blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Be selected from the aerial parts for feverfew field thistle Cephalanoplos segetum (Bunge) Kitam..
Chinese prescription of the present invention, take be apt to can clearing heat in YING system to divide, the Cortex Moutan of blood system excess-heat is monarch, minister is with the Folium Isatidis of Radix Scutellariae and the clearing away heat and cooling blood of eliminating fire and detoxication, assistant is with the YIN nourishing Radix Rehmanniae of battalion thoroughly, with Herba Cirsii with cooling blood for hemostasis, removing blood stasis to reduce swelling effect for making.This prescription is simple in structure, and 5 flavor Chinese medicines are by the principle compatibility of " monarch ", and each property of medicine of distinguishing the flavor of brings out the best in each other, and gathers altogether the effect of clearing away heat from YING and blood systems.
Compared with prior art, the Chinese medicine composition for the poultry clearing away heat from YING and blood systems the present invention relates to has following advantage and marked improvement: 1. for poultry " distemper card ", to battalion, defend rapidly the characteristics of the change of disease, by adjusting each organ function of poultry, clearing away heat from YING and blood systems, effective to the respiratory tract infection that multiple cause of disease causes.2. Chinese prescription disclosed by the invention is comprised of 5 flavor Chinese medicines, and raw material is simple and easy to get, and cost is lower, economic and practical.3. this prescription be take Cortex Moutan and is monarch drug, with the principle compatibility of the flavor Chinese medicines such as Radix Scutellariae, Folium Isatidis, the Radix Rehmanniae, Herba Cirsii by " monarch ", in heat-clearing and toxic substances removing, has the effect of diathermanous yin nourishing.4. be pure Chinese medicinal preparation, significant to use, the minimizing drug residue of antibacterials in effective minimizing poultry farming process.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment mono-: the preparation of Chinese powder medicine
Chinese medicine composition is by Cortex Moutan 30 weight portions, Radix Scutellariae 30 weight portions, and Folium Isatidis 20 weight portions, the Radix Rehmanniae 15 weight portions, Herba Cirsii 10 weight portions form.The described Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.By each Chinese medicine co-grinding, cross 60 order spin vibration sieves, thicker Chinese medicinal granule is pulverized again, and always mixed Chinese medicine fine powder, be packed as the 1kg/ bag, obtains.The Chinese powder medicine of producing by this method, the mode of generally feeding by spice is for the control of the poultry " distemper card " such as broiler, laying hen, duck.While being used for the treatment of, this powder doubly can also be measured to boiled water punching stewing 30 minutes with 8-10, supernatant drinking-water, the medicinal residues spice, for the respiratory tract infection total effective rate of outbreak repeatedly more than 92%.
Embodiment bis-: the preparation of Chinese medicine oral liquid
Chinese medicine composition is by Cortex Moutan 50 weight portions, Radix Scutellariae 45 weight portions, and Folium Isatidis 40 weight portions, the Radix Rehmanniae 30 weight portions, Herba Cirsii 30 weight portions form.The described Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Take after Chinese medicine mixes and add 10 times of amounts (W/W) purified water immersion 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, in filtering residue, add again 8 times of amounts (W/W) purified water and be heated to boiling, be incubated 1 hour, filter, merge twice filtrate, heating is concentrated into crude drug than being 0.5kg/L, add ethanol to 75% (V/V), precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into to crude drug than being 1kg/L, add 0.3% (W/W) sodium benzoate anticorrosion, fill, gland and get final product.By the Chinese medicine oral liquid that this method is produced, can directly by drinking-water, apply, due to Chinese medicine, through extraction process, have onset characteristics rapidly.
Embodiment tri-: the preparation of Chinese medicine granules
Chinese medicine composition is by Cortex Moutan 45 weight portions, Radix Scutellariae 30 weight portions, and Folium Isatidis 20 weight portions, the Radix Rehmanniae 30 weight portions, Herba Cirsii 20 weight portions form.The described Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Take after Chinese medicine mixes and add 10 times of amounts (W/W) purified water immersion 5 hours, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches, in filtering residue, add again 8 times of amounts (W/W) purified water and be heated to boiling, be incubated 1 hour, filter, merge filtrate twice, heating is concentrated into crude drug than for 0.5kg/L, adds ethanol to 75% (V/V), precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is concentrated into to crude drug than for 5kg/L, add appropriate sucrose or glucose, granulate, dry, make the granule that crude drug content is 1kg/kg, packing and get final product.The characteristics such as by Chinese medicine granules prepared by this method, the aquation of can heating during application is opened, and feeds by drinking-water, has an onset rapid, and accumulating is convenient.
Embodiment tetra-: the clinical practice example of Chinese medicine composition clearing away heat from YING and blood systems of the present invention
For the further clinical application effect of checking Chinese prescription of the present invention, select that fowl disease is clinical and meet the case of " distemper card ", using the veterinary clinic common drug as positive control, carry out the curative effect contrast test.
1. materials and methods
1.1 test material
Chinese powder medicine, press the described method preparation of embodiment one; Chinese medicine oral liquid, press the described method preparation of embodiment two; Chinese medicine granules, press the described method preparation of embodiment three.
The positive control medicine: ciprofloxacin lactate soluble powder, antipyretic and antitoxic powder are all purchased from positive animal pharmaceutcal corporation, Ltd in Hebei.
Experimental animal is 18 age in days Ai Wei mattress commercial meat birds of morbidity, meets " distemper card " according to falling ill through and cuing open the inspection diagnosis.
1.2 test method
The white plumage broiler of Ai Wei mattress commercial generation of 18 age in days natural infection morbidities is 40000 plumages approximately, are diagnosed as the distemper card through cuing open inspection, are divided at random 4 groups.Wherein, positive controls 9972 plumages, ciprofloxacin lactate soluble powder, the administration of antipyretic and antitoxic powder by specification, every day 1 time, being used in conjunction 5 days is a course for the treatment of.
Chinese powder medicine group 9770 plumages, calculate dosage by 0.5% feed intake (W/W).Chinese medicine is directly admixed feedstuff and is fed, and every day 1 time, being used in conjunction 5 days is a course for the treatment of.
Chinese medicine oral liquid group and Chinese medicine granules group are respectively 9758 plumages and 9916 plumages, with the crude drug cubage, calculate dosage by 0.5% feed intake (W/W).Every day 1 time, being used in conjunction 5 days is a course for the treatment of.
2. result of the test
2.1 morbidity chicken public sentiment condition and diagnosis
Therapeutic test is the white plumage broiler of 18 age in days Ai Wei mattress commercial generation that Feicheng, Shandong Animal Raising Zone is raised with animal.This Animal Raising Zone has 8 hen houses that basic condition is basically identical, and every hen house livestock on hand broiler is 10000 plumages approximately.Raising to 14 age in days, after carrying out the bursa of fabricius vaccine immunity, wherein the chicken of 4 hen houses starts to occur respiratory symptom.Morbidity chicken initial stage main manifestations is cough, the obvious moist rale of respiratory tract, throws to take the ciprofloxacin lactate broad spectrum antibiotic and failed effectively to control respiratory symptom in 3 days, and feed intake, drinking-water day by day reduce.During to 17 age in days, chicken group lethargy in 4 hen houses of morbidity, feed intake die-offs, and the mortality chicken occurs, average mortality 2% left and right.The chicken that dies of illness is cutd open the visible torso bag of inspection, saccus abdominalis muddiness, and minority chicken air bag deposits cheesy exudate; Respiratory tract, duodenum diffuse hemorrhage, the pancreas edge is hemorrhage, thymus, kidney swelling, hemorrhage, a large amount of urates of ureter deposition.Chicken group's incidence and cut open the inspection symptom and meet that pathogenic heat enter blood, cloudy " the distemper card " of consumption wound battalion shows.
2.2 contrast test
Similar epidemic disease also occurred in this plant habitually in the past, adopted traditionally broad spectrum antibiotic in conjunction with " antipyretic and antitoxic powder " antiviral Comprehensive Treatment, can control to a certain extent dead continuing to increase, but the course for the treatment of was longer, and the later stage death rate is high.Through with the technical staff of plant, consulting, 4 hen houses of falling ill are carried out to the curative effect contrast test.Wherein, 1 hen house adopts ciprofloxacin lactate soluble powder compatibility " antipyretic and antitoxic powder ", as positive controls; Other 3 hen houses, random selection is used respectively Chinese powder medicine, Chinese medicine granules and Chinese medicine oral liquid as experimental group.The mortality rate that matched group and each experimental group were all added up in the course for the treatment of (5 days) is as shown in table 1.
Table 1 herbal mixture and antibacterial therapy result (5 days statistical datas)
* respectively organizing sample number, is by every hen house, to advance young number deduct the dead naughty number of accumulative total and obtain.
That positive controls adopts is antibiotic, after antiviral therapy, mortality rate descends to some extent, but until medication the 5th day still has 10-20 death only every day.Chinese powder medicine experimental group, medication, after the 4th day, death substantially occurs again, and Chinese medicine oral liquid, the medication of Chinese medicine granules experimental group substantially occur dead after the 3rd day.Show, Chinese drug-treated group of the present invention can effectively be controlled advancing of disease, and Chinese medicine is after extracting, and onset is very fast.
3. discuss
Clinical popular " distemper card " the most outstanding performance of fowl diseases in recent years is that the change of disease is rapid.The exopathogen visitor, after lung is defended and cleaned up in time, namely enters rapidly the blood heat-transformation, the absurd row of forcing blood.On the other hand, pathogenic heat is joined the army rapidly, and consumption wound battalion is cloudy.Thereby the chicken that dies of illness is cutd open inspection except respiratory tract, digestive tract extensive bleeding, pancreas, nephropathy be the typical case the most.On the Therapeutic Principle, if only focus on clearing away heat and cooling blood, think little of nutrition the moon, remove battalion's YIN pathogen poison, be difficult to radical cure.Antipyretic and antitoxic powder is formed by flavor Chinese prescriptions such as Rhizoma Coptidis, Indigo Naturalis, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygiis, is good at heat clearing away, removing heat from blood, loose table, but can not diathermanous clearing heat in YING system.So, treat such " distemper card " and use heat-clearing and toxin-vanquishing loose, in conjunction with antibacterials, though can control to a certain extent the development of epidemic disease, be difficult to eradicate.Chinese medicine of the present invention, take the clearing heat in YING system removing toxic substances as main on the principles of formulating prescriptions, be aided with diathermanous yin nourishing, removing heat from blood is analgesic, enters blood, consumption wound battalion cloudy " distemper card " for characteristics for the pathogenic heat of the rapid change of disease, has good prevention effect.
Claims (5)
1. Chinese medicine composition for the poultry clearing away heat from YING and blood systems, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Cortex Moutan 30-50 part, Radix Scutellariae 30-50 part, Folium Isatidis 20-40 part, Radix Rehmanniae 15-30 part, Herba Cirsii 15-30 part.
2. the Chinese medicine composition for the poultry clearing away heat from YING and blood systems according to claim 1, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: 50 parts of Cortex Moutans, 45 parts of Radix Scutellariaes, 40 parts of Folium Isatidiss, 30 parts, the Radix Rehmanniae, 30 parts of Herba Cirsiis.
3. the Chinese medicine composition for the poultry clearing away heat from YING and blood systems according to claim 1, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: 45 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 30 parts, the Radix Rehmanniae, 20 parts of Herba Cirsiis.
4. according to the described Chinese medicine composition for the poultry clearing away heat from YING and blood systems of claim 1-3 any one, it is characterized in that: this Chinese medicine composition is powder, granule or oral liquid.
5. according to the described Chinese medicine composition for the poultry clearing away heat from YING and blood systems of claim 1-3 any one, it is characterized in that: described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
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| CN103142768B (en) * | 2013-03-28 | 2015-02-18 | 重庆市畜牧科学院 | Anti-stress biostime traditional Chinese medicine composition for piglets and preparation method of traditional Chinese medicine composition |
| CN105395835A (en) * | 2015-12-23 | 2016-03-16 | 青岛汉河动植物药业有限公司 | Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1401370A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Extracted herbal medicine for treating chicken infectious bursa of Fabricius |
| CN102068549A (en) * | 2009-11-19 | 2011-05-25 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Quality control method for Chinese medicinal preparation heat clearing and blood cooling pills |
| CN102100835A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Plague-removing and cystoma-treating traditional veterinary medicament and preparation method thereof |
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| US20080057111A1 (en) * | 2006-08-29 | 2008-03-06 | Lixian Jiang | Herbal composition for flu prevention and treatment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1401370A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Extracted herbal medicine for treating chicken infectious bursa of Fabricius |
| CN102068549A (en) * | 2009-11-19 | 2011-05-25 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Quality control method for Chinese medicinal preparation heat clearing and blood cooling pills |
| CN102100835A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Plague-removing and cystoma-treating traditional veterinary medicament and preparation method thereof |
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