CN105233253A - Chinese herbal medicine compound preparation for treating swine fever high fever and preparation method thereof - Google Patents
Chinese herbal medicine compound preparation for treating swine fever high fever and preparation method thereof Download PDFInfo
- Publication number
- CN105233253A CN105233253A CN201510764053.5A CN201510764053A CN105233253A CN 105233253 A CN105233253 A CN 105233253A CN 201510764053 A CN201510764053 A CN 201510764053A CN 105233253 A CN105233253 A CN 105233253A
- Authority
- CN
- China
- Prior art keywords
- radix
- preparation
- swine fever
- parts
- chinese medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention relates to a Chinese herbal medicine compound preparation for treating swine fever high fever and a preparation method thereof. The Chinese herbal medicine compound preparation is prepared from, by weight, 30-50 parts of isatis roots, 20-40 parts of folium isatidis, 40-60 parts of astragalus membranaceus, 10-30 parts of scutellaria baicalensis, 20-40 parts of fructus forsythiae, 10-30 parts of licorice roots, 20-40 parts of dahurian patrinia herbs, 10-20 parts of prunella vulgaris, 5-10 parts of sodium indometacin, 5-15 parts of mannatide, 0.5-1 part of polysorbate and 0.1-0.3 part of sodium hydrogen sulfite. The Chinese herbal medicine compound preparation is prepared from pure natural traditional Chinese medicinal materials and appropriate anti-virus ingredients, no antibacterial or antibiotic drug residue exists, and the curative effect is more thorough.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind ofly treat compound Chinese medicinal preparation of swine fever hyperpyrexia disease and preparation method thereof.
Background technology
Along with the fast development of aquaculture, pig disease is also thereupon visible, in pig industry, the performance clinically of various swine diseases is diversified, the high heat that causes of unknown cause is thereupon visible clinically, and the clinical manifestation of hog cholera symptom is exactly heating paresthesia, does not feel any better after medication, most antibiotic and antimicrobial drug are all difficult to treatment, casualty rate progressively raises, and bring huge puzzlement to cultivation industry, economic loss also improves greatly.
It is that one has hyperinfection epidemic disease that swine fever is commonly called as " rinderpest ", and be one of Infectious Diseases threatening pig industry, it is characterized in that: acute, change in septic, organa parenchymatosum is hemorrhage, downright bad and infarction; Chronic in cellulosic necrotic enteritis, often there are paratyphoid fever and Bacillus pasteurii disease secondary in the later stage.A kind of Acute exposure sexually transmitted disease of pig, also known as hog cholera.Within 1885, first find in the U.S., propagate into different continents later.Most of China is economized generation.The cause of disease of American Veterinary scholar De Xinizi in 1903 and many Saites qualification primary disease is the swine fever virus in the pestivirus (Pestivirus) of Alphaherpesvirinae.Mainly through direct contact, or fall ill due to the vehicle of contact stain.Digestive tract, nasal membrane and the skin broken are all routes of infection.All can occur throughout the year, be many with spring and summer rainy season.
The symptom of swine fever: swine fever be the one that the swine fever virus belonged to by flaviviridae swine fever virus causes acute, heating, contagious infection infectious disease.There is hyperinfection and lethal.Swine fever Symptoms is fever, and body temperature is elevated to 40.5-41 DEG C, does not move back lastingly.Down in spirits is depressed, and by hair slightly disorderly, fear of cold is trembled, loss of appetite or stop eating, and addle is drunk in happiness, and walking hogback of standing is bent over, and myasthenia of limbs, is slow in action, and waves shakiness, has purulence gum; There is nervous symptoms in some pigs.General treatment swine fever, adopts high hot acupuncture needle effectiveness comparison good.The livestock temperature that high hot acupuncture needle cures mainly swine fever, blue ear, annulus, foot and mouth disease, pseudorabies, swine flue, transfecting gastroenteritis etc. and mixed infection thereof and causes raises the pathogenic disorders such as (in continued fever), spirit are depressed, whole body deteriorated blood, is commonly called as hyperpyrexia disease.The dorsal body setae that porcine circovirus causes is thick disorderly, ear is rubescent or blue, and whole skin is aubergine or redness, and there is petechial hemorrhage in pleura portion, back.The significantly curative effect of uniqueness is had to unmanageable viral, bacillary, the immunodeficiency diseases of antibiotic.
Mostly the high hot disease of current clinical treatment swine fever is Western medicine and antibiotic therapy, and effect is unsatisfactory, and easily produces the residual of medicine to pig collective, and fervescence does not move back, thus easy recurrent exerbation.
Summary of the invention
The object of the present invention is to provide and a kind ofly treat compound Chinese medicinal preparation of swine fever hyperpyrexia disease and preparation method thereof, this medicine adopts the Chinese crude drug of pure natural formulated with suitable antiviral ingredients, and without antimicrobial drug and antibiotics residues, curative effect is more thorough.
In order to achieve the above object, the present invention is by the following technical solutions:
The invention provides a kind of compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease, be made up of the raw material of following weight portion: Radix Isatidis 30 ~ 50, Folium Isatidis 20 ~ 40, the Radix Astragali 40 ~ 60, Radix Scutellariae 10 ~ 30, Fructus Forsythiae 20 ~ 40, Radix Glycyrrhizae 10 ~ 30, Herba Patriniae 20 ~ 40, Spica Prunellae 10 ~ 20, Indomethacin sodium 5 ~ 10, mannatide 5 ~ 15, tween 0.5 ~ 1 and sodium sulfite 0.1 ~ 0.3.
According to the compound Chinese medicinal preparation of above-mentioned treatment swine fever hyperpyrexia disease, be made up of the raw material of following weight portion: Radix Isatidis 30 ~ 40, Folium Isatidis 35 ~ 40, the Radix Astragali 40 ~ 50, Radix Scutellariae 10 ~ 25, Fructus Forsythiae 30 ~ 40, Radix Glycyrrhizae 10 ~ 20, Herba Patriniae 35 ~ 40, Spica Prunellae 10 ~ 16, Indomethacin sodium 8 ~ 10, mannatide 5 ~ 12, tween 0.9 ~ 1 and sodium sulfite 0.1 ~ 0.2.
According to the compound Chinese medicinal preparation of above-mentioned treatment swine fever hyperpyrexia disease, be made up of the raw material of following weight portion: Radix Isatidis 40 ~ 50, Folium Isatidis 20 ~ 35, the Radix Astragali 50 ~ 60, Radix Scutellariae 25 ~ 30, Fructus Forsythiae 20 ~ 30, Radix Glycyrrhizae 20 ~ 30, Herba Patriniae 20 ~ 35, Spica Prunellae 16 ~ 20, Indomethacin sodium 5 ~ 8, mannatide 12 ~ 15, tween 0.5 ~ 0.9 and sodium sulfite 0.2 ~ 0.3.
According to the compound Chinese medicinal preparation of above-mentioned treatment swine fever hyperpyrexia disease, be made up of the raw material of following weight portion: Radix Isatidis 35, Folium Isatidis 30, the Radix Astragali 35, Radix Scutellariae 15, Fructus Forsythiae 25, Radix Glycyrrhizae 18, Herba Patriniae 25, Spica Prunellae 17, Indomethacin sodium 6, mannatide 8, tween 0.5 and sodium sulfite 0.2.
The preparation method of the compound Chinese medicinal preparation of described treatment swine fever hyperpyrexia disease, comprises the steps:
1. decoct: crude drug is dried, pulverize the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Weighting raw materials Radix Isatidis, Folium Isatidis, the Radix Astragali, Radix Scutellariae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Patriniae and Spica Prunellae by weight, adds the water of above-mentioned eight taste crude drug gross weight 10 ~ 20 times, decocts 2 times, and first time decocts 1.5h, and second time decocts 1h; Filter, collect decocting liquid;
2. concentrate: combining step is decocting liquid 1., filter, filtrate leaves standstill, and getting supernatant concentration, to be concentrated into relative density at 70 DEG C of temperature be the concentrated extract of 1.1 ~ 1.3;
3. precipitate with ethanol: be that the alcoholic solution of 55-60% stirs cooling at temperature is 40 ~ 45 DEG C by step concentrated extract percent by volume 2., leave standstill 24 hours;
4. filter: filter, reclaim the ethanol in filtrate, then by centrifugal for filtrate 10 ~ 20min, get the water dilution that supernatant adds 5 times amount, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then membrane filtration, subpackage and get final product.
When 1. described step decocts, first time decocts the water adding crude drug gross weight 20 times, and second time decocts the water adding crude drug gross weight 10 times.
The wherein preferred Tween 80 of tween.
Described step 4. centrifugal rotational speed is 3500 ~ 5000r/min.
Described step 4. membrane filtration uses 0.45 μm of filter membrane.
the present invention selects effect of raw material as follows:
Radix Isatidis: have anti-bacteria and anti-virus, anti-leptospira, removing toxic substances, raising immunologic function, removing toxic substances of can relieving inflammation or internal heat, prevents disease, has effect to various bacteria.Infusion is to bacillus subtilis, staphylococcus aureus, and sarcine, escherichia coli, Bacillus typhi, paratyphoid fever bacillus, dysentery (will Hayes, Fu Shi) bacillus, bacillus enteritidis etc. have inhibitory action.
Folium Isatidis: resisting pathogenic microbes, anti-endotoxin effect, the in vitro tests of Folium Isatidis decoct has certain inhibitory action to staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium; Folium Isatidis also has inhibitory action to encephalitis b virus, mumps virus, influenza virus etc. and Folium Isatidis kills leptospiral effect in addition.
The Radix Astragali: there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Significantly can increase the total white blood cells in blood, promote phagocytic function and the sterilizing ability of neutrophilic granulocyte and macrophage, promote the lymphocyte transformation that PHA, COnA, PWM (phytolacca american) cause.Astragalus, to 60Co disposable total irradiation mouse spleen antibody-producting cell release hemolysin amount, serum lysozyme amount, has increasing action.To the garland formation rate of delayed hypersensitivity and C 3 b receptor of red blood cells rosette rate, erythrocyte one immune complex, all there are promotion in various degree or potentiation.
Radix Scutellariae: antibacterial, the specially good effect such as antifungal, antiinflammatory antiallergic action.Radix Scutellariae decoct 100% concentration, has inhibitory action to dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus, staphylococcus, hemolytic vessel used to hold grain at the imperial sacrifice coccus (a, B), Diplococcus pneumoniae, diphtheria corynebacterium etc.
Fructus Forsythiae: machaka, Hong Kong is commonly called as a string gold, is Oleaceae forsythia.There is heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Treat lunar pathogenic wind-warm, warm, pestilence, winter-warm syndrome, from the beginning of symptoms such as heatings.
Radix Glycyrrhizae: another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.A kind of tonification Chinese herbal medicine, QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, antiinflammatory, anti-allergic effects.Licorice root, adopts mice dimethylbenzene ear swelling model, acetic acid causes mouse peritoneum permeability and increase model, rat paw swelling induced by egg model and rat granuloma and to swell the antiinflammatory action of model, research Licorice root.Result Licorice root significantly can suppress mice dimethylbenzene ear swelling, the hypertrophy of rat paw swelling induced by egg, reduction Change of Peritoneal Permeability and suppression granuloma induced by implantation of cotton pellets.Conclusion Licorice root has good antiinflammatory action.
Herba Patriniae: claim bitter beneficial dish in the localities, acrid in the mouth, hardship, for there being strong foot odor taste during Chinese medicine infusion, to staphylococcus aureus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli, have inhibitory action, can stem cell regenerating be promoted, place hepatocellular degeneration effect.
Spica Prunellae: another name: wheat head Spica Prunellae, iron wire Spica Prunellae, Spica Prunellae decoct to dysentery bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus and staphylococcus, all have inhibitory action, has obvious therapeutic action to the heating paresthesia that bacterial disease causes
Indomethacin sodium: Indomethacin sodium be succeed in developing on indomethacin basis can be water-soluble nonsteroidal ntipyretic analgesic medicine.Have antipyretic, antiinflammatory significantly, analgesia, effect, some antibiotic of Indomethacin sodium portability arrives poultry infection site as florfenicol, cephalosporins, doxycycline isopreference, and assembles in high concentration, improves therapeutic effect.Clinical formulation can replace the medicine such as dipyrone, acetaminophen, make formulation cost drop by half, should be widely promoted use.
Mannatide: the medicine being enhancing immunity, is used for the treatment of various diseases that immune function lowly causes, can treats various virus, pathogenic bacterium, can treats Recurrent respiratory tract infection, chronic bronchitis, is used for the treatment of aplastic anemia, has leukocyte increasing and Platelet etc.
Tween: nonionic surfactant, can disturb the effect of antibacterial in the solution.
Sodium sulfite: white crystalline powder, has the abnormal smells from the patient of sulfur dioxide.At injection its antioxidation main, be convenient to the effect of preserving.
compared with prior art, the beneficial effect that obtains of the present invention:
Advantage of the present invention is the Chinese crude drug adopting pure natural, through decocting, extracting, concentrated, precipitate with ethanol, recovery, centrifugal formulated with suitable antiviral ingredients, preparation method is simple, drug residue free and toxic and side effects, therapeutic effect is good, can not cause recurrent exerbation, and treatment pig swine fever hyperpyrexia disease has desirable effect, do not affect food quality, provide a safe and reliable product to raiser.
usage and dosage:
The medication of this medicine is intramuscular injection, and ampoule is per kilogram 0.2mL, once-a-day, within 3rd, is a course for the treatment of.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described, but do not limit content of the present invention.
Following crude drug is commercially available, preferred genuine medicinal materials.
embodiment 1
Treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, be made up of the raw material of following weight portion: Radix Isatidis 30 ~ 50, Folium Isatidis 20 ~ 40, the Radix Astragali 40 ~ 60, Radix Scutellariae 10 ~ 30, Fructus Forsythiae 20 ~ 40, Radix Glycyrrhizae 10 ~ 30, Herba Patriniae 20 ~ 40, Spica Prunellae 10 ~ 20, Indomethacin sodium 5 ~ 10, mannatide 5 ~ 15, tween 0.5 ~ 1 and sodium sulfite 0.1 ~ 0.3.
The preparation method of the compound Chinese medicinal preparation of described treatment swine fever hyperpyrexia disease, comprises the steps:
1. decoct: crude drug is dried, pulverize the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Weighting raw materials Radix Isatidis, Folium Isatidis, the Radix Astragali, Radix Scutellariae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Patriniae and Spica Prunellae by weight, adds the water of above-mentioned eight taste crude drug gross weight 10 ~ 20 times, decocts 2 times, and first time decocts 1.5h, and second time decocts 1h; Filter, collect decocting liquid;
2. concentrate: combining step is decocting liquid 1., filter, filtrate leaves standstill, and getting supernatant concentration, to be concentrated into relative density at 70 DEG C of temperature be the concentrated extract of 1.1 ~ 1.3;
3. precipitate with ethanol: be that the alcoholic solution of 55-60% stirs cooling at temperature is 40 ~ 45 DEG C by step concentrated extract percent by volume 2., leave standstill 24 hours;
4. filter: filter, reclaim the ethanol in filtrate, then by centrifugal for filtrate 10 ~ 20min, get the water dilution that supernatant adds 5 times amount supernatant, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then membrane filtration, subpackage and get final product.
Medication is intramuscular injection, and ampoule is per kilogram 0.2mL, once-a-day, within 3rd, is a course for the treatment of.
embodiment 2
Treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, it is made up of the raw material of following weight portion: Radix Isatidis 35, Folium Isatidis 30, the Radix Astragali 45, Radix Scutellariae 15, Fructus Forsythiae 25, Radix Glycyrrhizae 18, Herba Patriniae 25, Spica Prunellae 17, Indomethacin sodium 6, mannatide 8, tween 0.5 and sodium sulfite 0.2.
Preparation method is as follows: 1. decoct: dried by crude drug, pulverizes the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Take each raw material of Chinese medicine by weight, add crude drug gross weight 20 times and 10 times of soak by water 2 times respectively, first time decocts 1.5h, and second time decocts 1h; 2. concentrate: collecting decoction, filtering and concentrating, it is the thick paste of 1.1 that filtrate is concentrated into relative density at 70 DEG C of temperature; 3. precipitate with ethanol: by step thick paste percent by volume be 2. 60% alcoholic solution stir at temperature is 40 ~ 45 DEG C, cooling, leave standstill 24 hours; 4. filter: filter, reclaim the ethanol in filtrate, then be the centrifugal 10min of 5000 turns/min by filtrate at rotating speed, get the water dilution that supernatant adds 5 times amount supernatant, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then 0.45 μm of membrane filtration, subpackage both obtained.
embodiment 3
Treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, it is made up of the raw material of following weight portion: Radix Isatidis 30, Folium Isatidis 35, the Radix Astragali 40, Radix Scutellariae 10, Fructus Forsythiae 20, Radix Glycyrrhizae 10, Herba Patriniae 20, Spica Prunellae 10, Indomethacin sodium 5, mannatide 5, tween 0.7 and sodium sulfite 0.3.
Preparation method is as follows: 1. decoct: dried by crude drug, pulverizes the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Take each raw material of Chinese medicine by weight, add crude drug gross weight 20 times and 10 times of soak by water 2 times respectively, first time decocts 1.5h, and second time decocts 1h; 2. concentrate: collecting decoction, filtering and concentrating, it is the thick paste of 1.15 that filtrate is concentrated into relative density at 70 DEG C of temperature; 3. precipitate with ethanol: the alcoholic solution of step thick paste percent by volume 55% is 2. stirred at temperature is 40 ~ 45 DEG C, cooling, leaves standstill 24 hours; 4. filter: filter, reclaim the ethanol in filtrate, then be the centrifugal 15min of 5000 turns/min by filtrate at rotating speed, get the water dilution that supernatant adds 5 times of supernatant, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then 0.45 μm of membrane filtration, subpackage both obtained.
embodiment 4
Treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, it is made up of the raw material of following weight portion: Radix Isatidis 36, Folium Isatidis 16, the Radix Astragali 13, Radix Scutellariae 16, Fructus Forsythiae 13, Radix Glycyrrhizae 17, Herba Patriniae 18, Spica Prunellae 12, Indomethacin sodium 8, mannatide 7, tween 0.5 and sodium sulfite 0.2.
Preparation method is as follows: 1. decoct: dried by crude drug, pulverizes the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Take each raw material of Chinese medicine by weight, add crude drug gross weight 20 times and 10 times of soak by water 2 times respectively, first time decocts 1.5h, and second time decocts 1h; 2. concentrate: collecting decoction, filtering and concentrating, it is the thick paste of 1.21 that filtrate is concentrated into relative density at 70 DEG C of temperature; 3. precipitate with ethanol: the alcoholic solution of step thick paste percent by volume 60% is 2. stirred at temperature is 40 ~ 45 DEG C, cooling, leaves standstill 24 hours; 4. filter: filter, reclaim the ethanol in filtrate, then be the centrifugal 12min of 5000 turns/min by filtrate at rotating speed, get the water dilution that supernatant adds 5 times of supernatant, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then 0.45 μm of membrane filtration, subpackage both obtained.
embodiment 5
Treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, it is made up of the raw material of following weight portion: Radix Isatidis 41, Folium Isatidis 28, the Radix Astragali 52, Radix Scutellariae 23, Fructus Forsythiae 36, Radix Glycyrrhizae 21, Herba Patriniae 20, Spica Prunellae 10, Indomethacin sodium 5, mannatide 6, tween 0.5 and sodium sulfite 0.3.
Preparation method is as follows: 1. decoct: dried by crude drug, pulverizes the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Take each raw material of Chinese medicine by weight, add crude drug gross weight 20 times and 10 times of soak by water 2 times respectively, first time decocts 1.5h, and second time decocts 1h; 2. concentrate: collecting decoction, filtering and concentrating, it is the thick paste of 1.13 that filtrate is concentrated into relative density at 70 DEG C of temperature; 3. precipitate with ethanol: the alcoholic solution of step thick paste percent by volume 58% is 2. stirred at temperature is 40 ~ 45 DEG C, cooling, leave standstill 24 hours, 4. filter: filter, reclaim the ethanol in filtrate, then be the centrifugal 10min of 5000 turns/min by filtrate at rotating speed, get the water dilution that supernatant adds 5 times, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then 0.45 μm of membrane filtration, subpackage both obtained.
embodiment 6
Treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, it is made up of the raw material of following weight portion: Radix Isatidis 43, Folium Isatidis 20, the Radix Astragali 50, Radix Scutellariae 17, Fructus Forsythiae 38, Radix Glycyrrhizae 21, Herba Patriniae 32, Spica Prunellae 20, Indomethacin sodium 5, mannatide 5, tween 1 and sodium sulfite 0.2.
Preparation method is as follows: 1. decoct: dried by crude drug, pulverizes the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Take each raw material of Chinese medicine by weight, add crude drug gross weight 20 times and 10 times of soak by water 2 times respectively, first time decocts 1.5h, and second time decocts 1h; 2. concentrate: collecting decoction, filtering and concentrating, it is the thick paste of 1.2 that filtrate is concentrated into relative density at 70 DEG C of temperature; 3. precipitate with ethanol: the alcoholic solution of step thick paste percent by volume 55% is 2. stirred at temperature is 40 ~ 45 DEG C, cooling, leave standstill 24 hours, 4. filter: filter, reclaim the ethanol in filtrate, then be the centrifugal 15min of 5000 turns/min by filtrate at rotating speed, get the water dilution that supernatant adds 5 times, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then 0.45 μm of membrane filtration, subpackage both obtained.
The medication of this medicine is intramuscular injection, and ampoule is per kilogram 0.2ml, once-a-day, within 3rd, is a course for the treatment of.
formulation Example 7 ~ 28,in table 1.
With concrete zoopery, effect of the present invention is described below:
clinical trial example:
The drug effect that the like product that this product and city sell carries out same dosage compares, choose on pig farm, Jiaozhuo 30 ages in the first year, body weight homogeneous, all have swine fever heating paresthesia in early stage, be divided into two groups, test one group 15, test two groups 15, vena cava anterior injection respectively, starts to carry out Drug therapy to the pig of two test group morbidities, tests one group for this product, test two groups of reagents by the high heat of commercially available treatment swine fever, administration is treated respectively, and observe clinical treatment situation, result of the test is as following table 2:
in the inventive method, centrifugal rotational speed is 5000 turns/min, centrifugal Main Function is the solid particle in suspension and not tolerantly separates with liquid, reduces the existence of some insoluble matters, greatly improves the active ingredient of Chinese medicine extraction liquid, make the stability of product, therapeutic effect improves greatly.
Claims (7)
1. treat a compound Chinese medicinal preparation for swine fever hyperpyrexia disease, it is characterized in that being made up of the raw material of following weight portion: Radix Isatidis 30 ~ 50, Folium Isatidis 20 ~ 40, the Radix Astragali 40 ~ 60, Radix Scutellariae 10 ~ 30, Fructus Forsythiae 20 ~ 40, Radix Glycyrrhizae 10 ~ 30, Herba Patriniae 20 ~ 40, Spica Prunellae 10 ~ 20, Indomethacin sodium 5 ~ 10, mannatide 5 ~ 15, tween 0.5 ~ 1 and sodium sulfite 0.1 ~ 0.3.
2. the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Isatidis 30 ~ 40, Folium Isatidis 35 ~ 40, the Radix Astragali 40 ~ 50, Radix Scutellariae 10 ~ 25, Fructus Forsythiae 30 ~ 40, Radix Glycyrrhizae 10 ~ 20, Herba Patriniae 35 ~ 40, Spica Prunellae 10 ~ 16, Indomethacin sodium 8 ~ 10, mannatide 5 ~ 12, tween 0.9 ~ 1 and sodium sulfite 0.1 ~ 0.2.
3. the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Isatidis 40 ~ 50, Folium Isatidis 20 ~ 35, the Radix Astragali 50 ~ 60, Radix Scutellariae 25 ~ 30, Fructus Forsythiae 20 ~ 30, Radix Glycyrrhizae 20 ~ 30, Herba Patriniae 20 ~ 35, Spica Prunellae 16 ~ 20, Indomethacin sodium 5 ~ 8, mannatide 12 ~ 15, tween 0.5 ~ 0.9 and sodium sulfite 0.2 ~ 0.3.
4. the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Isatidis 35, Folium Isatidis 30, the Radix Astragali 35, Radix Scutellariae 15, Fructus Forsythiae 25, Radix Glycyrrhizae 18, Herba Patriniae 25, Spica Prunellae 17, Indomethacin sodium 6, mannatide 8, tween 0.5 and sodium sulfite 0.2.
5. the preparation method of the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 1, is characterized in that comprising the steps:
1. decoct: crude drug is dried, pulverize the powder grinding to form 80 ~ 200 mesh sieves, for subsequent use; Weighting raw materials Radix Isatidis, Folium Isatidis, the Radix Astragali, Radix Scutellariae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Patriniae and Spica Prunellae by weight, adds the water of above-mentioned eight taste crude drug gross weight 10 ~ 20 times, decocts 2 times, and first time decocts 1.5h, and second time decocts 1h; Filter, collect decocting liquid;
2. concentrate: combining step is decocting liquid 1., filter, filtrate leaves standstill, and getting supernatant concentration, to be concentrated into relative density at 70 DEG C of temperature be the concentrated extract of 1.1 ~ 1.3;
3. precipitate with ethanol: be that the alcoholic solution of 55-60% stirs cooling at temperature is 40 ~ 45 DEG C by step concentrated extract percent by volume 2., leave standstill 24 hours;
4. filter: filter, reclaim the ethanol in filtrate, then by centrifugal for filtrate 10 ~ 20min, get the water dilution that supernatant adds 5 times amount, add Indomethacin sodium, mannatide, tween and sodium sulfite, stirring and dissolving, then membrane filtration, subpackage and get final product.
6. the preparation method of the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 5, is characterized in that: described step 4. centrifugal rotational speed is 3500 ~ 5000r/min.
7. the preparation method of the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 5, is characterized in that: described step 4. membrane filtration uses 0.45 μm of filter membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510764053.5A CN105233253B (en) | 2015-11-11 | 2015-11-11 | A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510764053.5A CN105233253B (en) | 2015-11-11 | 2015-11-11 | A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105233253A true CN105233253A (en) | 2016-01-13 |
| CN105233253B CN105233253B (en) | 2018-06-19 |
Family
ID=55031242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510764053.5A Active CN105233253B (en) | 2015-11-11 | 2015-11-11 | A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105233253B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641655A (en) * | 2016-01-22 | 2016-06-08 | 江西傲新生物科技有限公司 | Traditional Chinese medicine composition for preventing foot-and-mouth disease and preparing method and application thereof |
| CN106176893A (en) * | 2016-07-07 | 2016-12-07 | 中国热带农业科学院热带生物技术研究所 | Croton cascarilloides root and the application of extract thereof |
| CN106668383A (en) * | 2016-12-26 | 2017-05-17 | 新昌县奥而特农业科技有限公司 | Feed additive for poultry and preparation method of feed additive |
| CN107456571A (en) * | 2017-08-01 | 2017-12-12 | 田东雄桂牧业有限公司 | A kind of medicine for treating pig epidemic diarrhea and preparation method thereof |
| CN109432392A (en) * | 2018-12-29 | 2019-03-08 | 河北肽都生物科技有限公司 | A kind of peptide formulations and preparation method thereof for treating African swine fever |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530602A (en) * | 2008-03-13 | 2009-09-16 | 张玉国 | Traditional Chinese medicine for treating swine fever |
| CN101554414A (en) * | 2008-04-09 | 2009-10-14 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine mixture for treating livestock and poultry virosis and preparation method thereof |
-
2015
- 2015-11-11 CN CN201510764053.5A patent/CN105233253B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530602A (en) * | 2008-03-13 | 2009-09-16 | 张玉国 | Traditional Chinese medicine for treating swine fever |
| CN101554414A (en) * | 2008-04-09 | 2009-10-14 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine mixture for treating livestock and poultry virosis and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 周璐: "中草药治猪瘟五处方", 《吉林农业》 * |
| 张子龙: "猪瘟的综合治疗", 《中兽医医药杂志》 * |
| 曹光明: "《中药工程学》", 30 June 1994 * |
| 曹艳子: "植物源抑菌物质的筛选及其引用", 《现代畜牧兽医》 * |
| 田新民: "中草药对猪病毒性疾病的预防和控制研究进展", 《农学学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641655A (en) * | 2016-01-22 | 2016-06-08 | 江西傲新生物科技有限公司 | Traditional Chinese medicine composition for preventing foot-and-mouth disease and preparing method and application thereof |
| CN106176893A (en) * | 2016-07-07 | 2016-12-07 | 中国热带农业科学院热带生物技术研究所 | Croton cascarilloides root and the application of extract thereof |
| CN106668383A (en) * | 2016-12-26 | 2017-05-17 | 新昌县奥而特农业科技有限公司 | Feed additive for poultry and preparation method of feed additive |
| CN107456571A (en) * | 2017-08-01 | 2017-12-12 | 田东雄桂牧业有限公司 | A kind of medicine for treating pig epidemic diarrhea and preparation method thereof |
| CN109432392A (en) * | 2018-12-29 | 2019-03-08 | 河北肽都生物科技有限公司 | A kind of peptide formulations and preparation method thereof for treating African swine fever |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105233253B (en) | 2018-06-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105233253A (en) | Chinese herbal medicine compound preparation for treating swine fever high fever and preparation method thereof | |
| CN103271230B (en) | Traditional Chinese medicine feed for promoting pig growth and preparation method as well as application thereof | |
| CN102872381B (en) | Traditional Chinese medicine composition for treating epidemic parotitis | |
| CN104257763B (en) | A kind of saline cistanche water extract, preparation method and its usage | |
| CN102671174A (en) | Traditional Chinese medicine preparation for preventing and treating livestock bowel diseases | |
| CN103989762B (en) | Chinese medicine composition of internal organs relieving cough and resolving phlegm and preparation method thereof is rushed down in a kind of heat clearing away | |
| CN103356888B (en) | Traditional Chinese medicinal granules for treating infantile pneumonia | |
| CN105381044A (en) | Traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry | |
| CN103041320B (en) | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method thereof | |
| CN102631590B (en) | Method for preparing traditional Chinese medicine (TCM) for treating summer-heat and damp type colitis | |
| CN102526356B (en) | Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry | |
| CN101849996A (en) | Three-drug adder-wort powder and preparation method thereof | |
| CN104491456A (en) | Impediment eliminating and collateral dredging paste for knee joint rheumatic arthritis and preparation | |
| CN105169327B (en) | A kind of pharmaceutical composition and preparation method thereof for treating porcine diarrhea disease | |
| CN104721510A (en) | Jiedu Zhitong preparation for acute pharyngitis and preparing method thereof | |
| CN104306761A (en) | Granules for treating cold and preparation method thereof | |
| CN104147399A (en) | Pharmaceutical preparation for swine fever | |
| CN104208168B (en) | A kind of for compound traditional Chinese medicine composite treating poultry respiratory infection and preparation method thereof | |
| WO2015149391A1 (en) | Preparation of traditional chinese medicine for treating chronic enteritis and preparation method therefor | |
| CN103735906A (en) | Chinese herb preparation for treating dry bronchiectasis and preparation method thereof | |
| CN105597011A (en) | Method for preparing traditional Chinese medicine composition for treating acute or chronic rhinitis | |
| CN104524187B (en) | A kind of Chinese medicine preparation for the treatment of laryngopharynx swelling and pain and preparation method thereof | |
| CN103638412B (en) | Multiple-effect Chinese medicinal formulae of a kind of quick elimination pulmonary persistent ailment and preparation method thereof | |
| CN106176995A (en) | A kind of be applied to pig erysipelas, Fel Gallus domesticus poison Chinese medicine | |
| CN106309596A (en) | Compound pure natural granule for treating cold and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 450000 Henan Zhengzhou airport comprehensive economic experimentation area Xingang Avenue East Side Applicant after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451100 east of Xingang Avenue, Xinzheng City, Zhengzhou, Henan Applicant before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |