CN105233253B - A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease and preparation method thereof - Google Patents
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of compound Chinese medicinal preparations for treating swine fever hyperpyrexia disease and preparation method thereof, are made of the raw material of following parts by weight：Radix Isatidis 30~50, folium isatidis 20~40, Radix Astragali 40~60, radix scutellariae 10~30, Fructus Forsythiae 20~40, Radix Glycyrrhizae 10~30, field pennycress 20~40, selfheal 10~20, indometacin sodium 5~10, mannatide 5~15, tween 0.5~1 and sodium hydrogensulfite 0.1~0.3.The drug is formulated using pure natural Chinese medicine with suitable antiviral ingredients, no antimicrobial and antibiotics residues, and curative effect is more thorough.
Description
Technical field
The invention belongs to veterinary drug technical fields, and in particular to a kind of compound Chinese medicinal preparation and its system for treating swine fever hyperpyrexia disease
Preparation Method.
Background technology
With the fast development of aquaculture, pig disease is also therewith as it can be seen that various swine diseases are clinically in pig industry
Performance is diversified, and clinically high fever caused by unknown cause is therewith as it can be seen that swine fever disease symptoms clinical manifestation is exactly to generate heat
Symptom is not felt any better after medication, and most antibiotic and antimicrobial are all difficult to treat, and casualty rate is stepped up, to cultivation industry
Huge puzzlement is brought, economic loss also greatly improves.
Swine fever be commonly called as " rinderpest " be it is a kind of there is highly infectious epidemic disease, be threaten pig breeding industry Infectious Diseases it
One, it is characterized in that：It is acute, change in septic, organa parenchymatosum's bleeding, necrosis and infarct；Chronic is in cellulosic gangrenosum acne intestines
Inflammation, later stage often have paratyphoid and the pasteurellosis secondary.It is a kind of Acute exposure sexually transmitted disease of pig, also known as hog cholera.1885
Year finds first in the U.S., travels to different continents later.There is generation in most of China province.American Veterinary scholar in 1903
De Xinizi and more Saites identify that the cause of disease of this disease is the pestivirus of Alphaherpesvirinae（Pestivirus）In swine fever virus.
Mainly by being in direct contact or being fallen ill due to the medium of contact stain.Alimentary canal, nasal membrane and the skin of rupture are
Route of infection.It can all occur throughout the year, be more using spring and summer rainy season.
The symptom of swine fever：One kind is acute caused by swine fever is the swine fever virus belonged to as flaviviridae swine fever virus, generates heat, connects
It touches property and infects infectious disease.With highly infectious and lethal.Swine fever Symptoms are fever, and body temperature is increased to 40.5-41 DEG C,
It does not move back persistently.Down in spirits is depressed, and hair slightly disorderly, tremble by chilly, anorexia or stops eating, and dirty water is drunk in happiness, walking hogback of standing
It bends over, weakness of limbs is slow in action, and waves shakiness, there is purulence gum;There are nervous symptoms in some pigs.General treatment swine fever, is adopted
It is relatively good with high fever acupuncture needle effect.High fever acupuncture needle cures mainly swine fever, blue ear, annulus, aftosa, pseudo- mad dog, swine flu, transfecting stomach
Livestock temperature caused by enteritis etc. and its mixed infection increases（In continued fever）, the pathogenic disorders such as spiritual depressed, whole body sepsis,
It is commonly called as hyperpyrexia disease.Dorsal body setae caused by circovirus is thick disorderly, ear is rubescent or blue, and whole skin is in aubergine or red, pleura
There is petechial hemorrhage at portion, back.Have to viral, bacillary, immunodefiiciency disease that antibiotic is difficult to control notable and unique
The effect of.
Clinical treatment swine fever high fever disease is mostly Western medicine and antibiosis extract for treating at present, and effect is unsatisfactory, and to pig
Collective easily generates the residual of drug, and fervescence does not move back, so as to easy recurrent exerbation.
Invention content
The object of the present invention is to provide a kind of compound Chinese medicinal preparations for treating swine fever hyperpyrexia disease and preparation method thereof, should
Drug is formulated using pure natural Chinese medicine with suitable antiviral ingredients, no antimicrobial and antibiotics residues, is treated
Effect is more thorough.
In order to achieve the above object, the present invention uses following technical scheme：
The present invention provides a kind of compound Chinese medicinal preparations for treating swine fever hyperpyrexia disease, are made of the raw material of following parts by weight：
Radix Isatidis 30~50, folium isatidis 20~40, Radix Astragali 40~60, radix scutellariae 10~30, Fructus Forsythiae 20~40, Radix Glycyrrhizae 10~30, field pennycress
20~40, selfheal 10~20, indometacin sodium 5~10, mannatide 5~15, tween 0.5~1 and sodium hydrogensulfite 0.1
~0.3.
According to the compound Chinese medicinal preparation of above-mentioned treatment swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：Radix Isatidis
30~40, folium isatidis 35~40, Radix Astragali 40~50, radix scutellariae 10~25, Fructus Forsythiae 30~40, Radix Glycyrrhizae 10~20, field pennycress 35~40,
Selfheal 10~16, indometacin sodium 8~10, mannatide 5~12, tween 0.9~1 and sodium hydrogensulfite 0.1~0.2.
According to the compound Chinese medicinal preparation of above-mentioned treatment swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：Radix Isatidis
40~50, folium isatidis 20~35, Radix Astragali 50~60, radix scutellariae 25~30, Fructus Forsythiae 20~30, Radix Glycyrrhizae 20~30, field pennycress 20~35,
Selfheal 16~20, indometacin sodium 5~8, mannatide 12~15, tween 0.5~0.9 and sodium hydrogensulfite 0.2~
0.3。
According to the compound Chinese medicinal preparation of above-mentioned treatment swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：Radix Isatidis
35th, folium isatidis 30, Radix Astragali 35, radix scutellariae 15, Fructus Forsythiae 25, Radix Glycyrrhizae 18, field pennycress 25, selfheal 17, indometacin sodium 6, sweet dew gather
Glycopeptide 8, tween 0.5 and sodium hydrogensulfite 0.2.
The preparation method of the compound Chinese medicinal preparation of the treatment swine fever hyperpyrexia disease, includes the following steps：
1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It weighs in parts by weight
Bulk pharmaceutical chemicals Radix Isatidis, folium isatidis, Radix Astragali, radix scutellariae, Fructus Forsythiae, Radix Glycyrrhizae, field pennycress and selfheal add in above-mentioned eight tastes bulk pharmaceutical chemicals gross weight
The water of 10 ~ 20 times of amount decocts 2 times, decocts 1.5h for the first time, decocts 1h for the second time；Decocting liquid is collected in filtration；
2. it concentrates：Merge step 1. decocting liquid, filtering, filtrate stands, and takes supernatant concentration opposite at a temperature of being concentrated into 70 DEG C
Density is 1.1 ~ 1.3 concentrated extract；
3. alcohol precipitation：With the ethanol solution that percent by volume is 55-60% it is 40 ~ 45 in temperature by the concentrated extract of step 2.
Cooling is stirred at DEG C, stands 24 hours；
4. it filters：Filtering, recycle filtrate in ethyl alcohol, then by filtrate centrifuge 10 ~ 20min, take supernatant add 5 times amount
Water dilutes, and adds in indometacin sodium, mannatide, tween and sodium hydrogensulfite, stirring and dissolving, then membrane filtration, packing and is
.
When the step decocts 1., the water for adding in 20 times of bulk pharmaceutical chemicals total weight is decocted for the first time, and second of decoction adds in former
Expect the water of 10 times of medicine total weight.
The wherein preferred Tween 80 of tween.
4. centrifugal rotational speed is 3500 ~ 5000r/min to the step.
4. membrane filtration uses 0.45 μm of filter membrane to the step.
The present invention selects the effect of raw material as follows：
Radix Isatidis：With anti-bacteria and anti-virus, anti-Leptospira, removing toxic substances, immune function is improved, can relieve inflammation or internal heat removing toxic substances, in advance
Anti- disease has effect to various bacteria.Infusion is to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, wound
Cold bacillus, paratyphoid A bacillus, dysentery（Shiga, Freund）Bacillus, bacillus enteritidis etc. have inhibiting effect.
Folium isatidis：Resisting pathogenic microbes, anti-endotoxin effect, the in vitro test of smalt leaf decoction to staphylococcus aureus,
Alpha streptococcus, diplococcus meningitidis, streptococcus pneumonia, micrococcus catarrhalis, typhoid bacillus, Escherichia coli, Bacillus influenzae, diphtheria bar
Bacterium and shigella dysenteriae have certain inhibiting effect；Folium isatidis also has inhibition to japanese encephalitis virus, mumps virus, influenza virus etc.
In addition folium isatidis plays the role of killing Leptospira effect.
Radix Astragali：With invigorating qi for strengthening superficies, the effect of diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.It can dramatically increase white thin in blood
Born of the same parents' sum promotes the phagocytic function and sterilizing ability of neutrophil leucocyte and macrophage, promotes PHA, COnA, PWM (America quotient
Land) caused by lymphocyte transformation.Huang Mao disposable full-body exposure mouse spleen antibody-producting cell release hemolysins to 60Co
Amount, serum lysozyme amount, there is increasing action.It is immune to delayed allergy and C 3 b receptor of red blood cells rosette rate, red blood cell one
The garland formation rate of compound, there is different degrees of promotion or humidification.
Radix scutellariae：The special efficacys such as antibacterial, antimycotic, anti-inflammatory antiallergic action.100% concentration of radix scutellariae decoction, to shigella dysenteriae, wound
Cold bacillus, paratyphosum Bacterium, comma bacillus, Escherichia coli, proteus, Pseudomonas aeruginosa, staphylococcus, hemolytic vessel used to hold grain at the imperial sacrifice coccus
（A, B）, Diplococcus pneumopniae, corynebacterium diphtheriae etc. have inhibiting effect.
Fructus Forsythiae：Machaka, Hong Kong are commonly called as a string of gold medals, are Oleaceae forsythias.With heat-clearing, removing toxic substances, dissipating bind disappears
It is swollen.Lunar wind-warm syndrome, warm, warm epidemic disease, winter-warm syndrome are treated, from the beginning of symptoms such as fevers.
Radix Glycyrrhizae：Alias：State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root.A kind of help Chinese herbal medicine, invigorating middle warmer and replenishing QI；Emergency is stopped
Bitterly；It moistens the lung and relieve the cough；Purging intense heat and detonicating；Coordinating the drug actions of a prescription.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, anti-inflammatory, anti-allergic effects.Radix Glycyrrhizae
Decocting liquid causes mouse peritoneum permeability to increase model, rat egg albumen foot swelling using mouse dimethylbenzene ear swelling model, acetic acid
Swollen model and swollen hyperplasia of rat granuloma model study the anti-inflammatory effect of Licorice root.As a result Licorice root can significantly press down
Mouse dimethylbenzene ear swelling processed, rat paw swelling induced by egg reduce Change of Peritoneal Permeability and inhibit the hyperplasia of granuloma induced by implantation of cotton pellets.Knot
There is preferable anti-inflammatory effect by Licorice root.
Field pennycress：Claim bitter beneficial dish, acrid flavour, hardship, for there is strong foot odour taste during Chinese medicine infusion, to golden yellow Portugal in the localities
Grape coccus, typhoid bacillus, Pseudomonas aeruginosa, Escherichia coli, has inhibiting effect at shigella dysenteriae, can promote stem cell regenerating, places liver
Cell degeneration effect.
Selfheal：Alias：Wheat head selfheal, iron wire selfheal, selfheal decoction is to shigella dysenteriae, typhoid bacillus, cholera
Vibrios, Escherichia coli, proteus, Pseudomonas aeruginosa and staphylococcus have inhibiting effect, to fever caused by bacteriosis
Symptom has obvious therapeutic action
Indometacin sodium：Indometacin sodium is that the antipyretic town of water soluble nonsteroidal is succeeded in developing on the basis of Indomethacin
Pain drug.With significant antipyretic, anti-inflammatory, analgesia, effect, indometacin sodium can carry certain antibiotic such as Florfenicol, head
Spore class antibiotic, fortimicin isopreference reach livestock and poultry infection site, and assemble in high concentration, improve therapeutic effect.In clinic
It may replace the drugs such as analgin, paracetamol on formula, make formulation cost drop by half, should be widely promoted use.
Mannatide：It is the medicine of strengthen immunity, for treating the low caused various illnesss of immunity function, can treat
Various viruses, pathogenic bacteria can treat Recurrent respiratory tract infection, chronic bronchitis, be risen for treating alpastic anemia, having
Leucocyte and Platelet etc..
Tween：Nonionic surface active agent may interfere with the effect of bacteriostatic agent in the solution.
Sodium hydrogensulfite：White crystalline powder has the smell of sulfur dioxide.In parenteral solution, its is anti-oxidant with main, just
In the effect of preservation.
Compared with prior art, the advantageous effect that the present invention obtains：
It is an advantage of the invention that using pure natural Chinese medicine, through decocting, extracting, concentrating, alcohol precipitation, recycling, centrifugation and suitable
Suitable antiviral ingredients are formulated, and preparation method is simple, and drug residue free and toxic side effect, therapeutic effect is good, will not be caused
Recurrent exerbation, treatment pig swine fever hyperpyrexia disease have ideal effect, do not influence food quality, providing a safety to raiser can
The product leaned on.
Usage and dosage：
The medication of the medicine is intramuscular injection, and ampoule is per kilogram 0.2mL, and once a day, three are a treatment
Journey.
Specific embodiment
With reference to embodiment to further description of the present invention, but it is not intended to limit present disclosure.
Bulk pharmaceutical chemicals below are commercially available, preferred genunie medicinal materials.
Embodiment 1
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, is made of the raw material of following parts by weight：Radix Isatidis 30~50,
Folium isatidis 20~40, Radix Astragali 40~60, radix scutellariae 10~30, Fructus Forsythiae 20~40, Radix Glycyrrhizae 10~30, field pennycress 20~40, selfheal
10~20, indometacin sodium 5~10, mannatide 5~15, tween 0.5~1 and sodium hydrogensulfite 0.1~0.3.
The preparation method of the compound Chinese medicinal preparation of the treatment swine fever hyperpyrexia disease, includes the following steps：
1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It weighs in parts by weight
Bulk pharmaceutical chemicals Radix Isatidis, folium isatidis, Radix Astragali, radix scutellariae, Fructus Forsythiae, Radix Glycyrrhizae, field pennycress and selfheal add in above-mentioned eight tastes bulk pharmaceutical chemicals gross weight
The water of 10 ~ 20 times of amount decocts 2 times, decocts 1.5h for the first time, decocts 1h for the second time；Decocting liquid is collected in filtration；
2. it concentrates：Merge step 1. decocting liquid, filtering, filtrate stands, and takes supernatant concentration opposite at a temperature of being concentrated into 70 DEG C
Density is 1.1 ~ 1.3 concentrated extract；
3. alcohol precipitation：With the ethanol solution that percent by volume is 55-60% it is 40 ~ 45 in temperature by the concentrated extract of step 2.
Cooling is stirred at DEG C, stands 24 hours；
4. it filters：The ethyl alcohol in filtrate is recycled in filtering, and filtrate then is centrifuged 10 ~ 20min, and supernatant is taken to add in 5 times of amounts
The water of clear liquid dilutes, addition indometacin sodium, mannatide, tween and sodium hydrogensulfite, stirring and dissolving, then membrane filtration,
It dispenses to obtain the final product.
Medication is intramuscular injection, and ampoule is per kilogram 0.2mL, and once a day, three as a treatment course.
Embodiment 2
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：It is Radix Isatidis 35, big
Leafiness 30, Radix Astragali 45, radix scutellariae 15, Fructus Forsythiae 25, Radix Glycyrrhizae 18, field pennycress 25, selfheal 17, indometacin sodium 6, mannatide 8,
Tween 0.5 and sodium hydrogensulfite 0.2.
Preparation method is as follows：1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It presses
Parts by weight weigh each Chinese medicine material, and respectively plus 20 times and 10 times water of bulk pharmaceutical chemicals total weight decoct 2 times, decoct 1.5h for the first time,
Second of decoction 1h；2. it concentrates：Collecting decoction, filtering and concentrating, filtrate be concentrated at a temperature of 70 DEG C relative density be 1.1 it is thick
Cream；3. alcohol precipitation：By the thick paste of step 2. with the ethanol solution that percent by volume is 60% be 40 ~ 45 DEG C in temperature at stir, it is cold
But, 24 hours are stood；4. it filters：The ethyl alcohol in filtrate is recycled in filtering, then centrifuges filtrate for 5000 turns/min in rotating speed
10min takes supernatant to add the water dilution of 5 times of amount supernatants, adds in indometacin sodium, mannatide, tween and bisulfite
Sodium, stirring and dissolving, then 0.45 μm of membrane filtration, packing both obtained.
Embodiment 3
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：It is Radix Isatidis 30, big
Leafiness 35, Radix Astragali 40, radix scutellariae 10, Fructus Forsythiae 20, Radix Glycyrrhizae 10, field pennycress 20, selfheal 10, indometacin sodium 5, mannatide 5,
Tween 0.7 and sodium hydrogensulfite 0.3.
Preparation method is as follows：1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It presses
Parts by weight weigh each Chinese medicine material, and respectively plus 20 times and 10 times water of bulk pharmaceutical chemicals total weight decoct 2 times, decoct 1.5h for the first time,
Second of decoction 1h；2. it concentrates：Collecting decoction, filtering and concentrating, it is 1.15 that filtrate, which is concentrated into the relative density at a temperature of 70 DEG C,
Thick paste；3. alcohol precipitation：It is stirred at being 40 ~ 45 DEG C in temperature by the ethanol solution of the thick paste of step 2. percent by volume 55%, it is cold
But, 24 hours are stood；4. it filters：The ethyl alcohol in filtrate is recycled in filtering, then centrifuges filtrate for 5000 turns/min in rotating speed
15min takes supernatant to add the water dilution of 5 times of supernatants, adds in indometacin sodium, mannatide, tween and sodium hydrogensulfite,
Stirring and dissolving, then 0.45 μm of membrane filtration, packing both obtained.
Embodiment 4
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：It is Radix Isatidis 36, big
Leafiness 16, Radix Astragali 13, radix scutellariae 16, Fructus Forsythiae 13, Radix Glycyrrhizae 17, field pennycress 18, selfheal 12, indometacin sodium 8, mannatide 7,
Tween 0.5 and sodium hydrogensulfite 0.2.
Preparation method is as follows：1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It presses
Parts by weight weigh each Chinese medicine material, and respectively plus 20 times and 10 times water of bulk pharmaceutical chemicals total weight decoct 2 times, decoct 1.5h for the first time,
Second of decoction 1h；2. it concentrates：Collecting decoction, filtering and concentrating, it is 1.21 that filtrate, which is concentrated into the relative density at a temperature of 70 DEG C,
Thick paste；3. alcohol precipitation：It is stirred at being 40 ~ 45 DEG C in temperature by the ethanol solution of the thick paste of step 2. percent by volume 60%, it is cold
But, 24 hours are stood；4. it filters：The ethyl alcohol in filtrate is recycled in filtering, then centrifuges filtrate for 5000 turns/min in rotating speed
12min takes supernatant to add the water dilution of 5 times of supernatants, adds in indometacin sodium, mannatide, tween and sodium hydrogensulfite,
Stirring and dissolving, then 0.45 μm of membrane filtration, packing both obtained.
Embodiment 5
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：It is Radix Isatidis 41, big
Leafiness 28, Radix Astragali 52, radix scutellariae 23, Fructus Forsythiae 36, Radix Glycyrrhizae 21, field pennycress 20, selfheal 10, indometacin sodium 5, mannatide 6,
Tween 0.5 and sodium hydrogensulfite 0.3.
Preparation method is as follows：1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It presses
Parts by weight weigh each Chinese medicine material, and respectively plus 20 times and 10 times water of bulk pharmaceutical chemicals total weight decoct 2 times, decoct 1.5h for the first time,
Second of decoction 1h；2. it concentrates：Collecting decoction, filtering and concentrating, it is 1.13 that filtrate, which is concentrated into the relative density at a temperature of 70 DEG C,
Thick paste；3. alcohol precipitation：It is stirred at being 40 ~ 45 DEG C in temperature by the ethanol solution of the thick paste of step 2. percent by volume 58%, it is cold
But, 24 hours are stood, 4. filtered：The ethyl alcohol in filtrate is recycled in filtering, then centrifuges filtrate for 5000 turns/min in rotating speed
10min takes supernatant that 5 times of water is added to dilute, and adds in indometacin sodium, mannatide, tween and sodium hydrogensulfite, and stirring is molten
Solution, then 0.45 μm of membrane filtration, packing both obtained.
Embodiment 6
A kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, it is made of the raw material of following parts by weight：It is Radix Isatidis 43, big
Leafiness 20, Radix Astragali 50, radix scutellariae 17, Fructus Forsythiae 38, Radix Glycyrrhizae 21, field pennycress 32, selfheal 20, indometacin sodium 5, mannatide 5,
Tween 1 and sodium hydrogensulfite 0.2.
Preparation method is as follows：1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；It presses
Parts by weight weigh each Chinese medicine material, and respectively plus 20 times and 10 times water of bulk pharmaceutical chemicals total weight decoct 2 times, decoct 1.5h for the first time,
Second of decoction 1h；2. it concentrates：Collecting decoction, filtering and concentrating, filtrate be concentrated at a temperature of 70 DEG C relative density be 1.2 it is thick
Cream；3. alcohol precipitation：It stirs, cools down at being 40 ~ 45 DEG C in temperature by the ethanol solution of the thick paste of step 2. percent by volume 55%,
24 hours are stood, is 4. filtered：The ethyl alcohol in filtrate is recycled in filtering, then centrifuges filtrate for 5000 turns/min in rotating speed
15min takes supernatant that 5 times of water is added to dilute, and adds in indometacin sodium, mannatide, tween and sodium hydrogensulfite, stirring
Dissolving, then 0.45 μm of membrane filtration, packing both obtained.
The medication of the medicine is intramuscular injection, and ampoule is per kilogram 0.2ml, and once a day, three are a treatment
Journey.
Formulation Example 7~28, is shown in Table 1.
Illustrate the effect of the present invention with specific zoopery below：
Clinical test example：
Compared with this product carries out with the drug effect of dosage with the similar product that city is sold, chose for 30 first year on Jiaozhuo pig farm
Age, weight is uniform, has swine fever heating paresthesia early period, is divided into two groups, tests one group 15, tests two groups 15, respectively ante-chamber
Intravenous injection starts pig fall ill to two test groups and carries out drug therapy, and one group of experiment tests two groups with commercially available for this product
Treatment swine fever high fever reagent, respectively administration treated, observe clinical treatment situation, result of the test such as the following table 2：
Centrifugal rotational speed is 5000 turns/min in the method for the present invention, the main function of centrifugation be the solid particle in suspension and
Not tolerant is separated with liquid, reduces the presence of some insoluble matters, is greatly improved the effective ingredient of Chinese medicine extract, is made product
Stability, therapeutic effect greatly improve.
Claims (3)
1. a kind of compound Chinese medicinal preparation for treating swine fever hyperpyrexia disease, it is characterised in that be made of the raw material of following parts by weight：Plate is blue
Root 35, folium isatidis 30, Radix Astragali 35, radix scutellariae 15, Fructus Forsythiae 25, Radix Glycyrrhizae 18, field pennycress 25, selfheal 17, indometacin sodium 6, sweet dew
Glycan peptide 8, tween 0.5 and sodium hydrogensulfite 0.2；
The preparation method of the compound Chinese medicinal preparation of the treatment swine fever hyperpyrexia disease, includes the following steps：
1. it decocts：Bulk pharmaceutical chemicals are dried, the powder that attrition grinding is sieved into 80~200 mesh is spare；Raw material is weighed in parts by weight
Medicine Radix Isatidis, folium isatidis, Radix Astragali, radix scutellariae, Fructus Forsythiae, Radix Glycyrrhizae, field pennycress and selfheal add in above-mentioned eight tastes bulk pharmaceutical chemicals total weight 10
~ 20 times of water decocts 2 times, decocts 1.5h, second of decoction 1h for the first time；Decocting liquid is collected in filtration；
2. it concentrates：Merge step 1. decocting liquid, filtering, filtrate stands, take supernatant concentration be concentrated into 70 DEG C at a temperature of relative density
For 1.1 ~ 1.3 concentrated extract；
3. alcohol precipitation：By the concentrated extract of step 2. with the ethanol solution that percent by volume is 55-60% in the case where temperature is 40 ~ 45 DEG C
Stirring cooling, stands 24 hours；
4. it filters：The ethyl alcohol in filtrate is recycled in filtering, and filtrate then is centrifuged 10 ~ 20min, takes the water that supernatant adds 5 times of amounts dilute
It releases, adds in indometacin sodium, mannatide, tween and sodium hydrogensulfite, stirring and dissolving, then membrane filtration, dispenses to obtain the final product.
2. the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 1, it is characterised in that：The step 4. from
Heart rotating speed is 3500 ~ 5000r/min.
3. the compound Chinese medicinal preparation for the treatment of swine fever hyperpyrexia disease according to claim 1, it is characterised in that：The step 4. film
Filtering uses 0.45 μm of filter membrane.
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| CN106176893B (en) * | 2016-07-07 | 2020-04-07 | 中国热带农业科学院热带生物技术研究所 | Application of radix crotonis argenteae and its extract |
| CN106668383A (en) * | 2016-12-26 | 2017-05-17 | 新昌县奥而特农业科技有限公司 | Feed additive for poultry and preparation method of feed additive |
| CN107456571A (en) * | 2017-08-01 | 2017-12-12 | 田东雄桂牧业有限公司 | A kind of medicine for treating pig epidemic diarrhea and preparation method thereof |
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