CN101554414A - Traditional Chinese medicine mixture for treating livestock and poultry virosis and preparation method thereof - Google Patents
Traditional Chinese medicine mixture for treating livestock and poultry virosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine mixture for treating livestock and poultry virosis and a preparation method thereof. The traditional Chinese medicine mixture contains the contents according to the parts by weight: 10-40 of radix isatidis, 10-40 of folium isatidis, 7-20 of honeysuckle, 3-9 of radix bupleuri, 1-6 of radix lithospermi, 5-20 of forsythia, 5-20 of scutellaria baicalensis, 3-9 of lightyellow sophora root, 2-7 of coptis chinensis, 4-11 of raidx astragali and 1-6 of liquorice. The traditional Chinese medicine mixture has reasonable compositions, convenient mixture taking, obvious effects and no mixture residues, conforms to the safe requirement of animal-derived foods and can be effectively applied to preventing and curing the infective livestock and poultry virosis of chicken flu, newcastle diseases, duck hepatitis viruses, swine fever, virus diarrhea, and the like. The traditional Chinese medicine mixture has the advantages of low cost, simple preparation process and no environmental pollution and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of herb mixture for the treatment of animal viral disease and preparation method thereof, belong to field of traditional Chinese veterinary.
Background technology
Viral disease is to have destructive a kind of infectious disease in the present livestock and poultry breeding industry most, and its characteristics are that sickness rate height, spread speed are fast, in case outburst will cause the tremendous economic loss to the raiser.Present most of antiviral drugs, comprise interferon (INF) and some other biological product, toxic and side effects that ubiquity is comparatively serious and untoward reaction, and some virus produced drug resistance to existing antiviral Western medicine, makes the application of some medicines be restricted.In addition, Bing Du strong variability, viral many serotypes and problems such as antigenic drift and antigenic shift make the research of vaccine have all difficulties; Simultaneously, there is remaining virulence or pathogenic in vaccine itself, and costs an arm and a leg, and is unfavorable for that large tracts of land promotes the use of.The defective that the forbidding of antiviral Western medicine and vaccine self exists is demanded developing new safe antiviral drugs urgently and is filled up this blank.At present, some single Chinese herbal medicine, Chinese herb compound and the chemical constituent of finding from Chinese herbal medicine in recent years have been proved has good antiviral activity, as single Chinese herbal medicine such as Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Cacumen Securinegae Suffruticosae, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), the Radixs Astragali; Chemical composition of Chinese materia medica such as Chinese medicine compound such as Lonicerae and Forsythiae Powder, Herba Sidae Rhombifoliae soup, XIAOQINGLONG TANG and glycyrrhizin, matrine.Simultaneously, Chinese medicine have have no side effect, no drug residue, virus be difficult for to produce plurality of advantages such as drug resistance, therefore, the anti virus herb DEVELOPMENT PROSPECT is wide.
Summary of the invention
The object of the present invention is to provide the herb mixture of the treatment animal viral disease of a kind of low cost, good effect, no drug residue, thereby overcome prior art Chinese medicine and western medicine and vaccine in treatment and prevent the deficiency of this type of disease.
Another object of the present invention is to provide the preparation method of this herb mixture.
The objective of the invention is to be achieved through the following technical solutions:
The invention provides a kind of herb mixture for the treatment of animal viral disease, this herb mixture comprises Radix Isatidis, Folium Isatidis, Flos Lonicerae, Radix Bupleuri, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Astragali, Radix Glycyrrhizae, and the weight proportion of mentioned component is as follows: Radix Isatidis 10-40 part, Folium Isatidis 10-40 part, Flos Lonicerae 7-20 part, Radix Bupleuri 3-9 part, Radix Arnebiae (Radix Lithospermi) 1-6 part, Fructus Forsythiae 5-20 part, Radix Scutellariae 5-20 part, Radix Sophorae Flavescentis 3-9 part, Rhizoma Coptidis 2-7 part, Radix Astragali 4-11 part, Radix Glycyrrhizae 1-6 part.
Further, the weight proportion of mentioned component is preferably: Radix Isatidis 20-30 part, Folium Isatidis 20-30 part, Flos Lonicerae 10-15 part, Radix Bupleuri 6-8 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Fructus Forsythiae 10-15 part, Radix Scutellariae 10-15 part, Radix Sophorae Flavescentis 6-8 part, Rhizoma Coptidis 4-6 part, Radix Astragali 8-10 part, Radix Glycyrrhizae 3-5 part.
The present invention also provides the preparation method of the herb mixture of above-mentioned treatment animal viral disease, comprises the steps:
1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri by weight ratio, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis by weight ratio, Rhizoma Coptidis powder be broken into coarse powder, add the 50%-75% ethanol that 6-10 doubly measures, reflux, extract, 2-3 time, each 1-3 hour, extracting solution merged, be evaporated to thick, must concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae by weight ratio, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil 2-4 time altogether, each 1-3 hour, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, add again to stir evenly behind the additives and leave standstill, filter, collect filtrate, filtrate is aseptic subpackaged goes into the sterilization bottle, promptly.
Wherein, additives used in the preparation method can be tween 80, and the amount of adding is that 0.3-1.0% is better with tween 80 concentration in medicinal liquid.
The herb mixture of treatment animal viral disease of the present invention is theoretical for instructing according to Chinese veterinarian, and based on the pestilence pathogeny, medication consolidates based on heat-clearing and toxic substances removing, the pestilence of dispelling.The principles of formulating prescriptions of the present invention are: Radix Isatidis, Folium Isatidis are principal agent, with heat-clearing and toxic substances removing, anti-inflammation, interior hot and suffocating clearly; That ministerial drug is that Flos Lonicerae, Radix Scutellariae, Rhizoma Coptidis, Fructus Forsythiae, Radix Sophorae Flavescentis increase jointly is antibiotic, the effect of antiinflammatory, inhibition virus replication; Radix Bupleuri, Radix Arnebiae (Radix Lithospermi) are adjuvant drug, and reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation and cooling blood help the merit of principal agent heat-clearing and toxic substances removing; The Radix Astragali, detoxification granulation promoting, invigorating QI to consolidate the body surface resistance, diuresis.Messenger drug is a Radix Glycyrrhizae, and lung moistening, emergency detoxifcation, coordinating the actions of various ingredients in a prescription are coughed in invigorating the spleen and replenishing QI, taste.Reasonable recipe of the present invention, all medicine compatibilities, but Synergistic detoxify jointly, get rid of evils, human body immunity improving power.
Medicine of the present invention is the oral liquid formulation of extraction preparation, taking convenience, and maximum characteristics are that medicine can be absorbed and bring into play due drug effect in animal body fast, can adopt mixed drink mode to concentrate administration simultaneously, are beneficial to mass prevention and mass treatment.
The herb mixture cost of treatment animal viral disease of the present invention is low, good effect, no drug residue, can be used for preventing and treating infectiousness animal viral diseases such as chicken influenza, newcastle disease, DHV, swine fever disease, viral diarrhea.
, it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way more specific description the present invention by the following example.
The specific embodiment
The preparation of the herb mixture of embodiment 1 treatment animal viral disease
Prescription: 20 parts of Radix Isatidis, 20 parts of Folium Isatidiss, 10 parts of Flos Loniceraes, 6 parts of Radix Bupleuri, 3 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Fructus Forsythiaes, 10 parts of Radix Scutellariaes, 6 parts of Radix Sophorae Flavescentiss, 4 parts of Rhizoma Coptidis, 8 parts of the Radixs Astragali, 3 parts in Radix Glycyrrhizae, additives are tween 80
Preparation method: 1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis, Rhizoma Coptidis powder be broken into coarse powder, add 75% ethanol of 8 times of amounts, reflux, extract, 3 times, each 2 hours, extracting solution merged, be evaporated to thick, concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil altogether 3 times, each 1.5 hours, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, adding tween 80 again and making its concentration in medicinal liquid is 0.5%, stir evenly and leave standstill, filter, collect filtrate, the aseptic subpackaged bottle of going into to sterilize of filtrate, promptly.
The preparation of the herb mixture of embodiment 2 treatment animal viral diseases
Prescription: 30 parts of Radix Isatidis, 30 parts of Folium Isatidiss, 15 parts of Flos Loniceraes, 8 parts of Radix Bupleuri, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 8 parts of Radix Sophorae Flavescentiss, 6 parts of Rhizoma Coptidis, 10 parts of the Radixs Astragali, 5 parts in Radix Glycyrrhizae, additives are tween 80.
Preparation method: 1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis, Rhizoma Coptidis powder be broken into coarse powder, add 65% ethanol of 9 times of amounts, reflux, extract, 3 times, each 1.5 hours, extracting solution merged, be evaporated to thick, concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil altogether 2 times, each 3 hours, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, adding tween 80 again and making its concentration in medicinal liquid is 0.8%, stir evenly and leave standstill, filter, collect filtrate, the aseptic subpackaged bottle of going into to sterilize of filtrate, promptly.
The preparation of the herb mixture of embodiment 3 treatment animal viral diseases
Prescription: 28 parts of Radix Isatidis, 25 parts of Folium Isatidiss, 9 parts of Flos Loniceraes, 5 parts of Radix Bupleuri, 4 parts of Radix Arnebiae (Radix Lithospermi)s, 18 parts of Fructus Forsythiaes, 14 parts of Radix Scutellariaes, 7.5 parts of Radix Sophorae Flavescentiss, 5 parts of Rhizoma Coptidis, 9 parts of the Radixs Astragali, 4.5 parts in Radix Glycyrrhizae, additives are tween 80.
Preparation method: 1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis, Rhizoma Coptidis powder be broken into coarse powder, add 50% ethanol of 7 times of amounts, reflux, extract, 2 times, each 3 hours, extracting solution merged, be evaporated to thick, concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil altogether 4 times, each 1 hour, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, adding tween 80 again and making its concentration in medicinal liquid is 0.7%, stir evenly and leave standstill, filter, collect filtrate, the aseptic subpackaged bottle of going into to sterilize of filtrate, promptly.
The preparation of the herb mixture of embodiment 4 treatment animal viral diseases
Prescription: 10 parts of Radix Isatidis, 10 parts of Folium Isatidiss, 7 parts of Flos Loniceraes, 3 parts of Radix Bupleuri, 1 part of Radix Arnebiae (Radix Lithospermi), 5 parts of Fructus Forsythiaes, 5 parts of Radix Scutellariaes, 3 parts of Radix Sophorae Flavescentiss, 2 parts of Rhizoma Coptidis, 4 parts of the Radixs Astragali, 1 part in Radix Glycyrrhizae, additives are tween 80
Preparation method: 1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis, Rhizoma Coptidis powder be broken into coarse powder, add 60% ethanol of 6 times of amounts, reflux, extract, 2 times, each 2 hours, extracting solution merged, be evaporated to thick, concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil altogether 2 times, each 2 hours, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, adding tween 80 again and making its concentration in medicinal liquid is 0.3%, stir evenly and leave standstill, filter, collect filtrate, the aseptic subpackaged bottle of going into to sterilize of filtrate, promptly.
The preparation of the herb mixture of embodiment 5 treatment animal viral diseases
Prescription: 40 parts of Radix Isatidis, 40 parts of Folium Isatidiss, 20 parts of Flos Loniceraes, 9 parts of Radix Bupleuri, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 9 parts of Radix Sophorae Flavescentiss, 7 parts of Rhizoma Coptidis, 11 parts of the Radixs Astragali, 6 parts in Radix Glycyrrhizae, additives are tween 80.
Preparation method: 1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis, Rhizoma Coptidis powder be broken into coarse powder, add 70% ethanol of 10 times of amounts, reflux, extract, 2 times, each 2.5 hours, extracting solution merged, be evaporated to thick, concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil altogether 2 times, each 2.5 hours, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, adding tween 80 again and making its concentration in medicinal liquid is 1.0%, stir evenly and leave standstill, filter, collect filtrate, the aseptic subpackaged bottle of going into to sterilize of filtrate, promptly.
The herb mixture of test example 1 embodiment 1 preparation is to the control test of chicken bursal disease
Experimental animal and grouping: choose near the healthy commodity chickling of 1000 20 ages in days of certain chicken house in Beijing, check that through agar gel diffusion test maternal antibody is all negative.Chicken is divided into five groups at random, 200 every group.I organizes negative matched group, neither infects IBD virus and does not also treat to medicine; II organizes positive matched group and only infects IBD virus, not drug treatment; The III group is treated for injection yolk antibody after infecting IBD virus; The IV group is for infecting IBD virus and treating with medicine of the present invention; The V group is prevention group, administration in continuous five days before the counteracting toxic substances.The separately isolated rearing under identical raising condition of each group.
Test method and dosage: except that negative control group (I group), all the other each groups adopt brush anus method counteracting toxic substances, typical infectious bursal disease symptom appearred after 24 hours: lethargy, feather pine disorderly, bow depressed, be afraid of cold flock together, appetite descends, row's yellow-white water sample loose stool, amount of drinking water increase, and carries out therapeutic test this moment.The amount of III group injection yolk antibody is 1ml/, medication 1 time; It is every plumage 1ml every day that the IV group is used Drug therapy of the present invention, dosage, logotype 5 days; Administration in continuous 5 days before the V group counteracting toxic substances, dosage is 1ml/ plumage/sky.Write down death toll every day, added up dead number of elements behind the counteracting toxic substances on the 8th day when no longer dead; Dead chicken is observed each internal organs pathological change by only cuing open inspection.
Efficacy determination: invalid: typical clinical symptom does not improve, even increases the weight of or death; Effectively: typical clinical symptom is clearly better, and feed intake increases, and spirit takes a turn for the better, and it is normal that drinking-water recovers, and feces is normal substantially, and cuing open the inspection internal organs has a small amount of uratosis, and fabricius bursa size and color and luster are normal substantially; Cure: spirit is normal, and it is normal to search for food, drink water, and it is smooth that feather becomes, and feces is normal, cuts open the inspection internal organs and does not have the urate calmness, and fabricius bursa size, color and luster are normal.Following table is the prevention effect of the present invention to infectious bursal disease:
| Group | Medication | Test chicken | Dead | Effectively | Effective percentage | Cure | Cure rate |
| Not | (only) | (only) | (only) | (％) | (only) | (％) | |
| I | Negative control group | 200 | 0 | - | - | - | - |
| II | Positive controls | 200 | 93 | - | - | - | - |
| III | The yolk antibody group | 200 | 40 | 160 | 80 | 134 | 67 |
| IV | The treatment by Chinese herbs group | 200 | 14 | 186 | 93 | 76 | 88 |
| V | The prevention group | 200 | 17 | 183 | 91.5 | - | - |
By last table as can be seen, herb mixture of the present invention, no matter be that treatment or prevention infectious bursal disease all have better curative effect, effective percentage all reaches more than 91.5%, cure rate can reach 88%, is better than the yolk antibody group.
The herb mixture of test example 2 embodiment 2 preparations is to the clinical therapeutic efficacy of infectious bursal disease
6 chicken houses are more than totally 15000 40 age in days chicken, and 6750 morbidities are wherein arranged, and typical infectious bursal disease symptom occurs, cut open inspection and are diagnosed as infectious bursal disease, treat with the herb mixture of the embodiment of the invention 2, and effective percentage is more than 91.0%.Illustrate that medicine of the present invention has the good restraining effect to infections chicken cloacal bursa virus.
The herb mixture of test example 3 embodiment 3,4,5 preparations is to the therapeutic effect of other viral disease of birds
Herb mixture with the present invention's preparation is treated newcastle disease, infectious laryngotracheitis of chicken, canine distemper, duck pestilence heat, and effect is as follows:
| Disease | Newcastle disease | Infectious bronchitis of chicken | Canine distemper | Duck pestilence heat |
| Sample number | 500 | 350 | 55 | 200 |
| The medication source | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 5 |
| Mortality rate (%) | 3.4 | 0 | 0 | 0 |
| Effective percentage (%) | 96.6 | 100.0 | 100.0 | 100.0 |
| Cure rate (%) | 84.2 | 92.4 | 89.0 | 96.0 |
The herb mixture of test example 4 embodiment 5 preparations is to the therapeutic effect of swine fever disease
Spring in 2007, pig farm, Hebei outburst swine fever, totally 200 hair diseases, sick pig spirit is depressed, loss of appetite, happiness drinking cold water, drowsiness, squeeze heap, dyspnea, cough, the big hard band blood that becomes dry, it is sick early stage to be diagnosed as swine fever through the veterinary.Use the herb mixture treatment of the embodiment of the invention 5 preparations, before the treatment colony house is carried out strict sterilization and handle; Adopt and mix the concentrated dispensing of drink mode, dosage is 2ml/ head/sky, and the medication 3 days seasonal disease pigs clinical symptoms and the mental status take a turn for the better, and medication is in the time of 6 days, and 200 sick pigs all get well, the clinical symptoms complete obiteration, and cure rate reaches 100%.Cure and pay a return visit after two months, the sick pig of rehabilitation is recurrence more not.
Medicine of the present invention not only has good therapeutical effect in early days to the swine fever disease, and diseases such as pig virus diarrhoea, influenza are also had fine prevention effect.
Claims (3)
1, a kind of herb mixture for the treatment of animal viral disease, it is characterized in that comprising Radix Isatidis, Folium Isatidis, Flos Lonicerae, Radix Bupleuri, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Astragali, Radix Glycyrrhizae, the weight proportion of mentioned component is as follows: Radix Isatidis 10-40 part, Folium Isatidis 10-40 part, Flos Lonicerae 7-20 part, Radix Bupleuri 3-9 part, Radix Arnebiae (Radix Lithospermi) 1-6 part, Fructus Forsythiae 5-20 part, Radix Scutellariae 5-20 part, Radix Sophorae Flavescentis 3-9 part, Rhizoma Coptidis 2-7 part, Radix Astragali 4-11 part, Radix Glycyrrhizae 1-6 part.
2, the herb mixture of the described treatment animal viral disease of claim 1 is characterized in that the weight proportion of mentioned component is preferably: Radix Isatidis 20-30 part, Folium Isatidis 20-30 part, Flos Lonicerae 10-15 part, Radix Bupleuri 6-8 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Fructus Forsythiae 10-15 part, Radix Scutellariae 10-15 part, Radix Sophorae Flavescentis 6-8 part, Rhizoma Coptidis 4-6 part, Radix Astragali 8-10 part, Radix Glycyrrhizae 3-5 part.
3, treat the preparation method of the herb mixture of animal viral disease as claimed in claim 1 or 2, it is characterized in that comprising the steps:
1) take by weighing Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri by weight ratio, use water vapour distillation volatile oil, collect distillate, carry out second distillation, volatile oil is collected standby; Aqueous solution after medicinal residues and the distillation is collected standby;
2) take by weighing Rhizoma Coptidis by weight ratio, Rhizoma Coptidis powder be broken into coarse powder, add the 50%-75% ethanol that 6-10 doubly measures, reflux, extract, 2-3 time, each 1-3 hour, extracting solution merged, be evaporated to thick, must concentrated solution;
3) take by weighing Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi), Radix Scutellariae, Radix Sophorae Flavescentis, the Radix Astragali, Radix Glycyrrhizae by weight ratio, aqueous solution after Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri medicinal residues and the distillation thereof of mentioned component and step 1) is added water fry in shallow oil 2-4 time altogether, each 1-3 hour, decocting liquid merged, be evaporated to thick, concentrated solution;
4) with step 2) with 3) two kinds of concentrated solutions and the volatile oil of step 1) merge, add water to every milliliter and be equivalent to crude drug in whole 1 gram, add again to stir evenly behind the additives and leave standstill, filter, collect filtrate, filtrate is aseptic subpackaged goes into the sterilization bottle, promptly.
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