CN102526356A - Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry - Google Patents
Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry. 30-50 parts of cortex moutan, 30-50 parts of scutellaria, 20-40 parts of folium isatidis, 15-30 parts of rhizome of rehmannia and 15-30 parts of herba cepbalanoplosis segeti are prepared into the traditional Chinese medicine compound. The traditional Chinese medicine compound has the effects of clearing Ying heat and cooling blood as well as expelling plague and relieving internal heat. The traditional Chinese medicine compound is used for treating the syndromes of pathogenic heat transferring Ying and heat invading blood of the poultry, such as chicken, ducks, and the like, and has the advantages that the effect is exact, no toxic side-effect exists, no medicine is maintained, and the like.
Description
Technical field
The invention belongs to veterinary drug preparation production and application, relate to a kind of Chinese prescription, especially relate to a kind of Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems.
Background technology
Along with the expansion of China's poultry farming scale, infectious disease more and more becomes the key factor of restriction culturing economic benefit.Simultaneously, Along with people's is to the concern of poultry prod food safety, and herbal medicine more and more comes into one's own in the fowl diseases Clinical Application.
The most infectious diseases of poultry are belonged to " distemper card " Chinese veterinarian, think due to the animal body being invaded by exogenous pathogen.Exopathogen is at first invaded lung and is defended, if can not in time clean up, perhaps the exopathogen virulence is stronger, then rapidly to the nutrient blood change of disease." the distemper card " of the clinical normal generation of fowl diseases in recent years mainly shows as the respiratory tract infection of rapid generation, and complete then crowd's lethargy is ingested, drunk water and decline to a great extent; It is muddy to cut open the visible air bag of inspection, respiratory tract, digestive tract hemorrhage, thymus, kidney swelling, hemorrhage.Such eqpidemic disease infective agent complicacy, conventional antimicrobial agents control generally is difficult to produce effects, and the morbidity poultry is many because of dehydration, organ failure's death, brings massive losses to poultry farming.Defend dialectically according to Chinese veterinarian's QI and blood battalion, in conjunction with generation and the epidemic characteristic of this disease and cut open the inspection pathological change, this disease belongs to pathogenic heat to be joined the army, consumes and hinder battalion's the moon, and distemper accumulates the performance of blood, intense heat in both QI and blood systems.The Therapeutic Principle should the clearing heat in YING system detoxifcation be main, is aided with diathermanous yin nourishing.
The Chinese prescription of fowl diseases clinical existing " eliminating pestilence and relieving toxicity " class is used at present.Yet; These herbal medicines remain in the fowl diseases Clinical Application in following problem: the infection that the Chinese prescription of 1. being reported causes to certain pathogen mostly; The marrow that this principles of formulating prescriptions have deviated from Chinese medicine be to nurse one's health animal body function but not to the ultimate principle of pathogen; On the other hand, mostly the generation that does not also fit into present fowl diseases is the clinical practice of some kinds of pathogen mixed infections.2. the Chinese prescription of being reported is complicated, and comprises the higher Chinese crude drugs of price such as Cornu Bubali, Flos Lonicerae, Radix Bupleuri, Fructus Forsythiae more, causes medicament composing prescription on the high side, has limited Chinese medicine in the fowl diseases Clinical Application.3. the present Chinese prescription of reporting that is applied to fowl diseases clinical " heat-clearing and toxic substances removing "; Be mainly used in heat-clearing and toxic substances removing, purging fire and cooling blood; Going into all diseases of blood for pathogenic heat has better curative effect, but present fowl diseases clinical popular " distemper card ", pathogenic factor divides the change of disease to battalion rapidly; Heat clearing away during treatment and do not pay close attention to clearing heat in YING system is difficult to receive produce effects.
Summary of the invention
In view of the deficiency of prior art, the objective of the invention is to provides a kind of Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems through prescription again after the Chinese medicine pharmacology is studied.Said composition is as a kind of pure Chinese medicinal preparation, and to the respiratory tract mixed infection of effective control poultry " distemper card ", and use, the minimizing drug residue of antibacterials is significant in the minimizing poultry farming process.
In order to solve the existing problem of background technology, the present invention adopts following technical scheme:
A kind of Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems, this Chinese medicine composition is prepared from the active component of following weight portion: Cortex Moutan 30-50 part, Radix Scutellariae 30-50 part, Folium Isatidis 20-40 part, Radix Rehmanniae 15-30 part, Herba Cirsii 15-30 part.
In a preferred embodiment of the present invention, the described Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems is prepared from the active component of following weight portion: 30 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 15 parts in the Radix Rehmanniae, 10 parts of Herba Cirsiis.
In another preferred embodiment of the present invention, the described Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems is prepared from the active component of following weight portion: 50 parts of Cortex Moutans, 45 parts of Radix Scutellariaes, 40 parts of Folium Isatidiss, 30 parts in the Radix Rehmanniae, 30 parts of Herba Cirsiis.
In another preferred embodiment of the present invention, the described Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems is prepared from the active component of following weight portion: 45 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 30 parts in the Radix Rehmanniae, 20 parts of Herba Cirsiis.
The present invention presses the general production technology of veterinary drug powder and produces the Chinese powder medicine of preparation, feeds or boiled water dashes stewing, the poultry of feeding after decocting through spice, and the clearing away heat from YING and blood systems that is used for poultry " distemper card " is prevented and treated.
The present invention is prepared into oral liquid by the general production technology production of veterinary drug oral liquid, also can produce the granule of preparation according to the veterinary drug granule technological process of production.
Therefore, the described Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems, it is powder, granule or oral liquid.Described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
According to the record of Chinese medicine historical data, above-mentioned 5 flavor Chinese crude drugs have following pharmacologically active and function cures mainly:
Cortex Moutan: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and pounce on the pain of injury; The rheumatism pyretic arthralgia.Be selected from the dry root bark of ranunculaceae peony.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Select the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi for use.
Folium Isatidis: heat clearing away, detoxifcation, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Be selected from the leaf or the branch and leaf of cruciferae isatis.
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Be selected from the fresh or exsiccant tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch., also claim Radix Rehmanniae.
Herba Cirsii: cooling blood for hemostasis, removing blood stasis to reduce swelling.Be used for epistaxis, spit blood, hematuria is had blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Be selected from aerial parts for feverfew field thistle Cephalanoplos segetum (Bunge) Kitam..
Chinese prescription of the present invention, with kind can the clearing heat in YING system branch, the Cortex Moutan of blood system excess-heat is monarch, minister is with the Folium Isatidis of the Radix Scutellariae and the clearing away heat and cooling blood of eliminating fire and detoxication, assistant is passed through the Radix Rehmanniae of battalion with YIN nourishing, with Herba Cirsii with cooling blood for hemostasis, removing blood stasis to reduce swelling effect for making.This prescription is simple in structure, and 5 flavor Chinese medicines are by the principle compatibility of " monarch ", and each property of medicine of distinguishing the flavor of brings out the best in each other, and gathers the effect of clearing away heat from YING and blood systems altogether.
Compared with prior art; The Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems that the present invention relates to has following advantage and marked improvement: the characteristics of 1. defending the change of disease to poultry " distemper card " rapidly to battalion; Through each organ function of adjustment poultry; Clearing away heat from YING and blood systems, effective to the respiratory tract infection that multiple cause of disease causes.2. Chinese prescription disclosed by the invention is made up of 5 flavor Chinese medicines, and raw material is simple and easy to, and cost is lower, and is economic and practical.3. this prescription is monarch drug with the Cortex Moutan, with the principle compatibility of flavor Chinese medicines such as Radix Scutellariae, Folium Isatidis, the Radix Rehmanniae, Herba Cirsii by " monarch ", in heat-clearing and toxic substances removing, has the effect of diathermanous yin nourishing.4. be pure Chinese medicinal preparation, significant to use, the minimizing drug residue of antibacterials in effective minimizing poultry farming process.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment one: the preparation of Chinese powder medicine
Chinese medicine composition is by Cortex Moutan 30 weight portions, Radix Scutellariae 30 weight portions, and Folium Isatidis 20 weight portions, the Radix Rehmanniae 15 weight portions, Herba Cirsii 10 weight portions are formed.The said Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary drug allusion quotation " related standards, and each ratio is weight portion.Each Chinese medicine is mixed pulverizing, cross 60 orders and revolve the sieve that shakes, thicker Chinese medicinal granule is pulverized once more, always mixes the Chinese medicine fine powder, is packed as the 1kg/ bag, promptly gets.By the Chinese powder medicine that this method is produced, the mode of generally feeding through spice is used for the control of poultry " distemper card " such as broiler, laying hen, duck.When being used to treat, can also this powder doubly being measured boiled water with 8-10 and dash stewing 30 minutes, supernatant drinking-water, the medicinal residues spice is for the respiratory tract infection total effective rate of outbreak repeatedly more than 92%.
Embodiment two: the preparation of Chinese medicine oral liquid
Chinese medicine composition is by Cortex Moutan 50 weight portions, Radix Scutellariae 45 weight portions, and Folium Isatidis 40 weight portions, the Radix Rehmanniae 30 weight portions, Herba Cirsii 30 weight portions are formed.The said Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary drug allusion quotation " related standards, and each ratio is weight portion.Add 10 times of amounts (W/W) purified water immersion 5 hours after taking by weighing the Chinese medicine mixing, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches; In filtering residue, add 8 times of amounts (W/W) purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrating twice; Heating is concentrated into crude drug than for 0.5kg/L, adds ethanol to 75% (V/V), precipitates 12 hours, supernatant heating recovery ethanol; And medicinal liquid is concentrated into crude drug than for 1kg/L, and it is anticorrosion to add 0.3% (W/W) sodium benzoate, and fill, gland promptly get.By the Chinese medicine oral liquid that this method is produced, can directly use through drinking-water, because Chinese medicine is handled through extracting, have onset characteristics rapidly.
Embodiment three: the preparation of Chinese medicine granules
Chinese medicine composition is by Cortex Moutan 45 weight portions, Radix Scutellariae 30 weight portions, and Folium Isatidis 20 weight portions, the Radix Rehmanniae 30 weight portions, Herba Cirsii 20 weight portions are formed.The said Chinese medicine of respectively distinguishing the flavor of is the prepared slices of Chinese crude drugs that meet " Chinese veterinary drug allusion quotation " related standards, and each ratio is weight portion.Add 10 times of amounts (W/W) purified water immersion 5 hours after taking by weighing the Chinese medicine mixing, be heated to boiling, be incubated 1 hour, wait the cold supernatant that leaches; In filtering residue, add 8 times of amounts (W/W) purified water again and be heated to boiling, be incubated 1 hour, filter, merge filtrating twice; Heating is concentrated into crude drug than for 0.5kg/L, adds ethanol to 75% (V/V), precipitates 12 hours, supernatant heating recovery ethanol; And medicinal liquid is concentrated into crude drug than for 5kg/L, and add an amount of sucrose or glucose, granulate; The granule that crude drug content is 1kg/kg is processed in oven dry, and packing promptly gets.Characteristics such as by the Chinese medicine granules of this method preparation, the aquation of can heating during application is opened, and feeds through drinking-water, and it is rapid to have an onset, and accumulating is convenient.
Embodiment four: the clinical practice instance of Chinese medicine composition clearing away heat from YING and blood systems of the present invention
For the further clinical application effect of checking Chinese prescription of the present invention, select that fowl disease is clinical and meet the case of " distemper card ", as positive control, carry out the curative effect contrast test with the veterinary clinic common drug.
1. materials and methods
1.1 test material
Chinese powder medicine is pressed embodiment one said method preparation; Chinese medicine oral liquid is pressed embodiment two said method preparations; Chinese medicine granules is pressed embodiment three said method preparations.
The positive control medicine: ciprofloxacin lactate soluble powder, antipyretic and antitoxic powder are all available from positive animal pharmaceutcal corporation, Ltd in the Hebei.
Experimental animal is 18 age in days Ai Wei mattress commercial meat birds of morbidity, according to morbidity through and cut open inspection diagnosis and meet " distemper card ".
1.2 test method
Ai Wei mattress commodity white about 40000 plumages of plumage broiler of generation of 18 age in days natural infections morbidity are diagnosed as the distemper card through cuing open inspection, are divided into 4 groups at random.Wherein, positive controls 9972 plumages, ciprofloxacin lactate soluble powder, the administration of antipyretic and antitoxic powder by specification, every day 1 time, logotype 5 days was a course of treatment.
Chinese powder medicine group 9770 plumages calculate dosage by 0.5% feed intake (W/W).Chinese medicine is directly admixed feedstuff and is fed, and every day 1 time, logotype 5 days was a course of treatment.
Chinese medicine oral liquid group and Chinese medicine granules group are respectively 9758 plumages and 9916 plumages, with the crude drug cubage, calculate dosage by 0.5% feed intake (W/W).Every day 1 time, logotype 5 days was a course of treatment.
2. result of the test
2.1 morbidity chicken public sentiment condition and diagnosis
Therapeutic test is that the 18 age in days Ai Wei mattress commodity white plumage broiler of generation of raising the sub-district is cultured in Feicheng, Shandong with animal.This breed sub-district has the hen house of 8 basic condition basically identicals, every about 10000 plumages of hen house livestock on hand broiler.Raising to 14 age in days, carry out the bursa of fabricius vaccine immunity after, wherein the chicken of 4 hen houses begins to occur respiratory symptom.Morbidity mainly shows as cough, the obvious moist rale of respiratory tract at the chicken initial stage, throws clothes ciprofloxacin lactate broad spectrum antibiotic and fails effective control breathing road symptom in 3 days, the minimizing day by day of feed intake, drinking-water.During to 17 ages in days, chicken crowd lethargy in 4 hen houses of morbidity, feed intake die-offs, and the mortality chicken occurs, average mortality about 2%.The chicken that dies of illness is cutd open the visible torso bag of inspection, saccus abdominalis is muddy, and minority chicken air bag deposits cheesy exudate; Respiratory tract, duodenum diffuse hemorrhage, the pancreas edge is hemorrhage, thymus, kidney swelling, hemorrhage, ureter deposits a large amount of urates.Chicken crowd's incidence and cut open the inspection symptom and meet that pathogenic heat are gone into blood, consumption is hindered battalion's cloudy " distemper card " and showed.
2.2 contrast test
Similar eqpidemic disease also took place in this plant habitually in the past, adopted broad spectrum antibiotic to combine " antipyretic and antitoxic powder " antiviral Comprehensive Treatment traditionally, and what may command was dead to a certain extent continues to increase, but the course of treatment is longer, and the later stage death rate is high.Warp is consulted with the technical staff of plant, and 4 hen houses of falling ill are carried out the curative effect contrast test.Wherein, 1 hen house adopts ciprofloxacin lactate soluble powder compatibility " antipyretic and antitoxic powder ", as positive controls; Other 3 hen houses are selected to use Chinese powder medicine, Chinese medicine granules and Chinese medicine oral liquid as experimental group respectively at random.The mortality rate that matched group and each experimental group were all added up in the course of treatment (5 days) is as shown in table 1.
Table 1 herbal mixture and antibacterial therapy result (5 days statistical datas)
* respectively organizing sample number, is to advance young number by every hen house to deduct that accumulative total is dead washes in a pan number and obtain.
That positive controls adopts is antibiotic, behind the antiviral therapy, mortality rate descends to some extent, but until medication the 5th day still has 10-20 death only every day.Chinese powder medicine experimental group, medication death basically occurs after the 4th day again, and Chinese medicine oral liquid, the medication of Chinese medicine granules experimental group basically occur dead after the 3rd day.Show that Chinese drug-treated group of the present invention is the development of control disease effectively, and Chinese medicine is after extracting, onset is very fast.
3. discuss
The most outstanding performance of fowl diseases clinical popular " distemper card " in recent years is that the change of disease is rapid.The exopathogen visitor in lung defend be not able in time clean up after, promptly go into the blood heat-transformation rapidly, the absurd row of forcing blood.On the other hand, pathogenic heat is joined the army rapidly, and it is cloudy that consumption is hindered battalion.Thereby the chicken that dies of illness is cutd open inspection except respiratory tract, digestive tract extensive bleeding, and pancreas, nephropathy be the typical case the most.On the Therapeutic Principle, if only pay attention to clearing away heat and cooling blood, it is cloudy to think little of nutrition, removes battalion's YIN pathogen poison, then is difficult to radical cure.Antipyretic and antitoxic powder is formed by flavor Chinese prescriptions such as Rhizoma Coptidis, Indigo Naturalis, Herba Schizonepetae, windproof, Rhizoma Et Radix Notopterygiis, is good at heat clearing away, removing heat from blood, the table that looses, but can not diathermanous clearing heat in YING system.So, treat such " distemper card " utilization heat-clearing and toxin-vanquishing and loose, in conjunction with antibacterials,, be difficult to eradicate though can control the development of eqpidemic disease to a certain extent.Chinese medicine according to the invention is main with the clearing heat in YING system detoxifcation on the principles of formulating prescriptions, is aided with diathermanous yin nourishing, removing heat from blood is analgesic, for the pathogenic heat of the rapid change of disease go into blood, consumption is hindered battalion's cloudy " distemper card " for characteristics, has good prevention effect.
Claims (6)
1. Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems, it is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: Cortex Moutan 30-50 part, Radix Scutellariae 30-50 part, Folium Isatidis 20-40 part, Radix Rehmanniae 15-30 part, Herba Cirsii 15-30 part.
2. the Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems according to claim 1 is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: 30 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 15 parts in the Radix Rehmanniae, 10 parts of Herba Cirsiis.
3. the Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems according to claim 1 is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: 50 parts of Cortex Moutans, 45 parts of Radix Scutellariaes, 40 parts of Folium Isatidiss, 30 parts in the Radix Rehmanniae, 30 parts of Herba Cirsiis.
4. the Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems according to claim 1 is characterized in that: this Chinese medicine composition is prepared from the active component of following weight portion: 45 parts of Cortex Moutans, 30 parts of Radix Scutellariaes, 20 parts of Folium Isatidiss, 30 parts in the Radix Rehmanniae, 20 parts of Herba Cirsiis.
5. according to each described Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems of claim 1-4, it is characterized in that: this Chinese medicine composition is powder, granule or oral liquid.
6. according to each described Chinese medicine composition that is used for the poultry clearing away heat from YING and blood systems of claim 1-4, it is characterized in that: described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103142768A (en) * | 2013-03-28 | 2013-06-12 | 重庆市畜牧科学院 | Anti-stress biostime traditional Chinese medicine composition for piglets and preparation method of traditional Chinese medicine composition |
| CN105395835A (en) * | 2015-12-23 | 2016-03-16 | 青岛汉河动植物药业有限公司 | Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry |
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| US20080057111A1 (en) * | 2006-08-29 | 2008-03-06 | Lixian Jiang | Herbal composition for flu prevention and treatment |
| CN102068549A (en) * | 2009-11-19 | 2011-05-25 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Quality control method for Chinese medicinal preparation heat clearing and blood cooling pills |
| CN102100835A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Plague-removing and cystoma-treating traditional veterinary medicament and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1401370A (en) * | 2002-09-27 | 2003-03-12 | 长春市动物药厂 | Extracted herbal medicine for treating chicken infectious bursa of Fabricius |
| US20080057111A1 (en) * | 2006-08-29 | 2008-03-06 | Lixian Jiang | Herbal composition for flu prevention and treatment |
| CN102068549A (en) * | 2009-11-19 | 2011-05-25 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Quality control method for Chinese medicinal preparation heat clearing and blood cooling pills |
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| CN103142768A (en) * | 2013-03-28 | 2013-06-12 | 重庆市畜牧科学院 | Anti-stress biostime traditional Chinese medicine composition for piglets and preparation method of traditional Chinese medicine composition |
| CN103142768B (en) * | 2013-03-28 | 2015-02-18 | 重庆市畜牧科学院 | Anti-stress biostime traditional Chinese medicine composition for piglets and preparation method of traditional Chinese medicine composition |
| CN105395835A (en) * | 2015-12-23 | 2016-03-16 | 青岛汉河动植物药业有限公司 | Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry |
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