CN103432340B - Chinese herbal medicine oral liquid for treating yellow scours of piglets - Google Patents
Chinese herbal medicine oral liquid for treating yellow scours of piglets Download PDFInfo
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- CN103432340B CN103432340B CN201310419633.1A CN201310419633A CN103432340B CN 103432340 B CN103432340 B CN 103432340B CN 201310419633 A CN201310419633 A CN 201310419633A CN 103432340 B CN103432340 B CN 103432340B
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Abstract
The invention relates to a Chinese herbal medicine oral liquid for treating yellow scours of piglets. The Chinese herbal medicine oral liquid is prepared from the following material medicines in parts by weight: 5-6 parts of pomegranate barks, 4-5 parts of wild chrysanthemum flowers, 3-4 parts of smoked plums, 3-4 parts of myrobalan, 2-3 parts of sculellaria barbata, 2-3 parts of eucalyptus robusta, 1-2 parts of Chinese yams, 1-2 parts of white atractylodes rhizomes and 1-2 parts of liquorice. The Chinese herbal medicine oral liquid disclosed by the invention is used for treating yellow scours of piglets, and has the characteristics of low cost, high cure rate, good effect, no toxic and side effects and the like, and is safe and convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet.
Background technology
Yellow scour of piglet is that the one of the newborn piglet caused by Escherichia coli is acute, height lethal infectious diseases.After escherichia coli enter intestine of young pigs, facility pili is adsorbed on intestinal mucosa, settles down propagation, produces a large amount of enterotoxin, piglet is dewatered and acutely suffers from diarrhoea.The medicine for the treatment of yellow scour of piglet is much Antibiotics Western medicine, although have certain therapeutic effect, shortcoming is that Drug resistance is serious.Chinese herbal medicine have natural, have no side effect, residual without chemicals, not easily the feature such as to develop immunity to drugs.The Chinese medicine preparation being used for the treatment of yellow scour of piglet is at present less, and weak effect, cure rate is low, and the course for the treatment of is long, and cost is high.
Summary of the invention
The object of the invention is to for the problems referred to above, a kind of Chinese herbal medicament oral liquid effectively can treating yellow scour of piglet is provided.
Technical scheme of the present invention is: a kind of Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet, it is made up of the crude drug of following weight parts: Pericarpium Granati 5-6 part, Flos Chrysanthemi Indici 4-5 part, Fructus Mume 3-4 part, Fructus Chebulae 3-4 part, Herba Scutellariae Barbatae 2-3 part, Folium Eucalypti Robustae 2-3 part, Rhizoma Dioscoreae 1-2 part, Rhizoma Atractylodis Macrocephalae 1-2 part, Radix Glycyrrhizae 1-2 part.
Making the preferred feedstock medicine weight portion that the present invention treats the Chinese herbal medicament oral liquid of yellow scour of piglet is: Pericarpium Granati 5 parts, Flos Chrysanthemi Indici 5 parts, Fructus Mume 3 parts, Fructus Chebulae 3 parts, Herba Scutellariae Barbatae 2 parts, Folium Eucalypti Robustae 2 parts, Rhizoma Dioscoreae 2 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 1 part, Radix Glycyrrhizae.
In prescription of the present invention, each component pharmacological effect is:
Pericarpium Granati effect: Pericarpium Granati another name Punica granatum L. shell, Fructus punicae granati skin, sour pomegranate skin, western pomegranate skin etc., sour in the mouth, warm in nature.Return large intestine, lung, kidney channel.Pericarpium Granati peel, containing tannin, wax, mannitol, phlegmatic temperament, gallic acid, malic acid, pectin and calcium oxalate, natural gum, inulin etc., also contains elaidic acid, Isoquercitrin etc.Experiment in vitro proves that its decoct all has inhibitory action to various bacteria such as escherichia coli.Effect of tool astringing intestine to stop diarrhea, hemostasis, anthelmintic.Be used for chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis etc.
Flos Chrysanthemi Indici effect: Flos Chrysanthemi Indici another name FLOS CHRYSANTHEMI INDICI flower, the bitter heart of a lotus seed, mountain Flos Chrysanthemi, Flos Chrysanthemi etc., cold nature, acrid in the mouth, hardship, return lung, Liver Channel.Flos Chrysanthemi Indici is containing volatile oil, sabinene and cephrol, another containing luteolin glycoside, the red glycoside chrysanthemaxanthin of chrysanthemum, epoxy phylloxanthin, luteolin, Flos Chrysanthemi Indici ketone and chrysanthemol, daucosterol, ambrosin, acacetin, mountain Yu's acid glyceride, Palmic acid etc., there is inhibitory action to escherichia coli etc.Effect of tool heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.Be used for carbuncle, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain etc.
Fructus Mume effect: Fructus Mume another name dark plum, close Chinese prunus mume (sieb.) sieb.et zucc., dry branch prunus mume (sieb.) sieb.et zucc., property is put down, sour in the mouth, puckery, returns liver, spleen, lung, large intestine channel.Fructus Mume fruit, containing citric acid, malic acid, oxalic acid, succinic acid and Fumaric acid, also contains 5 hydroxymethyl 2 furaldehyde.Contained volatile component, mainly contains benzaldehyde, benzyl alcohol and hexadecanoic acid.Tool is astringed the lung, astringing intestine to stop diarrhea, the effect of promoting the production of body fluid.For chronic malaria, chronic diarrhea, dysentery, vomiting etc.
Fructus Chebulae's effect: another name chebule, scold multitude, scold pears, son with the wind.Property flat, bitter in the mouth, micro-puckery, return lung, stomach, large intestine channel.Fructus Chebulae's fruit, containing tannin, still containing shikimic acid, dehydroshikimis acid, quininic acid, arabinose etc. and aminoacid, also contains terchebin, tannase, polyphenol oxidase, peroxidase and ascorbic acid oxidase etc.Effect of the grand gasification expectorant of tool, antidiarrheal dysentery.Incessantly, outward rush down for productive cough, outer dysentery etc.
Herba Scutellariae Barbatae effect: Herba Scutellariae Barbatae has another name called narrow leaf Herba Scutellariae indicae, property is pungent, cold, and bitter in the mouth, returns lung, liver, kidney channel.Herba Scutellariae Barbatae herb contains carthamin, isocarthamidin, high mountain baicalin, the yellow official seal glycoside of high mountain, stearic acid, alkaloid polysaccharide etc.Effect of tool heat-clearing and toxic substances removing, blood stasis dispelling diuresis, for furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice.
Folium Eucalypti Robustae effect: Folium Eucalypti Robustae another name mosquito son tree, Folium Eucalypti Robustae, property is flat, micro-pungent, mildly bitter flavor, GUIXIN, lung, large intestine channel.Be separated in Folium Eucalypti Robustae robustaol A, robustaol, Robustadial A, Folium Eucalypti Robustae dialdehyde B, Eucalyptus globulus Labill aldehyde etc.Tool dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic effect.For enteritis, dysentery, skin degerming etc.
Rhizoma Dioscoreae effect: Rhizoma Dioscoreae another name Rhizomadioscoreae, Rhizoma dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, profit cool in nature, sweet in the mouth, enters lung, spleen, kidney channel.Rhizoma Dioscoreae contains ruscogenin, polyphenol oxidase, contains glycoprotein, polysaccharide, cholesterol, various trace elements etc. again.Tool spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, for insufficiency of the spleen lack of appetite, have loose bowels loose stool, incessant chronic diarrhea etc.
Rhizoma Atractylodis Macrocephalae effect: Rhizoma Atractylodis Macrocephalae another name mountain Ji, Alpinia japonica (Thunb.) Miq., Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, warm in nature, bitter in the mouth, sweet, return spleen, stomach warp.The Rhizoma Atractylodis Macrocephalae contains volatile oil, atractylol, Rhizoma Atractylodis ketone, vitamin A etc.Tool increases effect of appetite, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic.Have loose bowels for insufficiency of the spleen lack of appetite, abdominal distention, edema etc.
Radix Glycyrrhizae effect: Radix Glycyrrhizae another name Glycyrrhizae, close sweet, close grass, state are old, Herba Hedyotis cantonensis, leather and fur, and property is put down, sweet in the mouth.Return 12 warps.Radix Glycyrrhizae mainly containing the composition such as glycyrrhizic acid, glycyrrhizin, 24-hydroxyl enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, Angelica Polysaccharide, there is antiulcer, promote pancreatic secretion, protect the liver, blood fat reducing, adjustment macrophage the effect such as phagocytic function.Glycyrrhizic acid is natural antidote, can be used for body defying age, enhancing immunity, maintenance water-electrolyte metabolism balance etc.Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, cushion toxicity, strong.
Prescription foundation of the present invention: yellow scour of piglet is that newborn piglet common bacteria is sick, after escherichia coli enter intestinal with piglet suckling, amount reproduction, the violent diarrhoea of piglet dehydration, immunity degradation, 3rd day is onset peak, yellow feces of suffering from diarrhoea, and then dehydration is dead, therefore in treatment, should with anti-inflammation, spleen invigorating dysentery relieving, enhancing immunity for the rule for the treatment of; Pericarpium Granati in prescription, Flos Chrysanthemi Indici, Fructus Chebulae, Herba Scutellariae Barbatae, antibacterial and bacteriostasis that Folium Eucalypti Robustae tool is stronger, Pericarpium Granati, Fructus Mume, Fructus Chebulae's astringing intestine to stop diarrhea promote the production of body fluid, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae replenishing QI to invigorate the spleen, raising body's immunity, Radix Glycyrrhizae sweet temperature QI invigorating and middle spleen invigorating, current twelve channels and collaterals, coordinating the actions of various ingredients in a prescription; In prescription all medicine phases and, play anti-inflammation, YIN nourishing and the production of body fluid promoting, spleen invigorating dysentery relieving altogether, strengthen effect of immunologic function, be applicable to treat yellow scour of piglet.
The present invention treats the Chinese herbal medicament oral liquid of yellow scour of piglet, is on the basis of carrying out a large amount of practical application, according to traditional medicine ancient prescription, forms, have good therapeutic effect to yellow scour of piglet in conjunction with modern popular disease, the screening of nosetiology theory.
Detailed description of the invention
The invention will be further described in conjunction with the embodiments.
Embodiment:
1, difference weighting raw materials (decoction pieces), Pericarpium Granati 200 g, Flos Chrysanthemi Indici 200 g, Fructus Mume 120 g, Fructus Chebulae 120 g, Herba Scutellariae Barbatae 80 g, Folium Eucalypti Robustae 80 g, Rhizoma Dioscoreae 80 g, the Rhizoma Atractylodis Macrocephalae 80 g, Radix Glycyrrhizae 40g;
2, above-mentioned raw materials medicine is ground into coarse powder respectively;
3, get above-mentioned nine taste Chinese herbal medicine coarse powder, decoct after 8000 mL that add water soak 1h, water opens rear slow fire boiling 30min; Filter to obtain first-time filtrate, medicinal residues add water again at every turn 6000 mL decoct secondaries, each 20min, filter respectively secondary and three filtrates; Merge three filtrates, be concentrated into about 900 mL;
4, by concentrated solution obtained above, add 0.05% sodium benzoate as antiseptic, add water to 1000mL, stir evenly, filter, fill, sterilizing, obtains Chinese herbal medicament oral liquid of the present invention.
Some test situation utilizing Chinese herbal medicament oral liquid of the present invention to carry out are as follows:
1, Chinese herbal medicament oral liquid of the present invention is to escherichia coli drug sensitive test
Choose clinical trouble yellow scour of piglet case, through being separated, identifying pathogen as escherichia coli O8.Get a certain amount of Chinese herbal medicament oral liquid of the present invention, every mL is containing crude drug 1g, and sterilizing, subpackage, 4 DEG C save backup.The escherichia coli O8 of clinical separation is first inoculated in flat board, after cultivating 18 h, selects colonies typical and be inoculated in 5 mL meat soups in 37 DEG C, after cultivating 18 h in 37 DEG C, bacterium liquid, than turbid, is diluted to 10 with meat soup by 0.5 Maxwell unit norm opacity tube
5cFU/mL, for subsequent use.
Medicament sensitivity test: adopt plate punch method, add 1g/mL Chinese herbal medicament oral liquid of the present invention in hole, is not advisable outside overfolw hole to fill it up with; Choose the generally acknowledged drug sensitive test of the good three kinds of antibiotic of escherichia coli effect as ciprofloxacin (1 μ g/mL), amikacin (1 μ g/mL), gentamycin (1 μ g/mL) is compared, be placed in 37 DEG C of constant incubators and cultivate 24 h, measure antibacterial circle diameter, the drug sensitive test of often kind of medicine in triplicate.Criterion: according to " pharmacology of Chinese materia medica " standard with " U.S. clinical Laboratory Standard institute version in 2005 is about drug sensitive test standardization ", namely bacteriostatic diameter >=20 mm is extremely quick, 20 mm> bacteriostatic diameter >=15 mm are Gao Min, 15 mm> bacteriostatic diameter >=10 mm are quick in being, 10 below mm are hypoallergenic.
Chinese herbal medicament oral liquid medicament sensitivity test of the present invention the results are shown in Table 1.
The drug sensitive test result mm of table 1 Chinese herbal medicament oral liquid of the present invention
| Medicine | Escherichia coli O8 |
| Ciprofloxacin | 15.0±0.8 |
| Amikacin | 16.8±0.3 |
| Gentamycin | 17.5±0.5 |
| Chinese herbal medicament oral liquid of the present invention | 22.2±1.0 |
Table 1 shows, and to escherichia coli O8, Chinese herbal medicament oral liquid of the present invention is extremely quick, and bacteriostatic diameter reaches 22.2 mm, and ciprofloxacin, amikacin and gentamycin are Gao Min.Drug sensitivity test shows, the inhibitory action of Chinese herbal medicament oral liquid of the present invention to escherichia coli O8 is the most responsive, and gentamycin takes second place, and amikacin, ciprofloxacin are slightly secondary, result shows, Chinese herbal medicament oral liquid of the present invention should as first-selection in the practice for the treatment of yellow scour of piglet.
2, the clinical trial of natural infection yellow scour of piglet
Natural occurrence swinery is provided by Changli County, Hebei province, Luan County, Leting County, Lulong County, each raiser in Funing County respectively, root according to clinical symptoms, cut open inspection change, animal inoculation test and laboratory examination results, be diagnosed as yellow scour of piglet.To infect swinery separately for test group, the dosage that morbidity swinery presses 10mL/ head is oral by this Chinese herbal medicament oral liquid, every day 2 times, dispensing 3 ~ 5d is a course for the treatment of, continue observation 3 ~ 5d after drug withdrawal, with clinical symptom disappearance, drinking-water, suckling and the mental status are recovered normal person and are judged to healing, binding of pathological cuts open inspection and takes a sample test result determination therapeutic effect again, statistics cure rate.Therapeutic outcome is in table 2.
The therapeutic effect (unit: head, %) of table 2 Chinese herbal medicament oral liquid natural infection of the present invention yellow dysentery of piglet pig
By the treatment to 129 natural infection yellow scour of piglet piglets, Chinese herbal medicament oral liquid of the present invention has significant therapeutic effect to sick pig, and average cure rate is 84.5%, and generally through 3 ~ 5d transference cure, suckling is normal.
Claims (2)
1. treat a Chinese herbal medicament oral liquid for yellow scour of piglet, it is characterized in that it is made up of the crude drug of following weight parts: Pericarpium Granati 5-6 part, Flos Chrysanthemi Indici 4-5 part, Fructus Mume 3-4 part, Fructus Chebulae 3-4 part, Herba Scutellariae Barbatae 2-3 part, Folium Eucalypti Robustae 2-3 part, Rhizoma Dioscoreae 1-2 part, Rhizoma Atractylodis Macrocephalae 1-2 part, Radix Glycyrrhizae 1-2 part.
2. the Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet according to claim 1, is characterized in that it is made up of the crude drug of following weight parts: Pericarpium Granati 5 parts, Flos Chrysanthemi Indici 5 parts, Fructus Mume 3 parts, Fructus Chebulae 3 parts, Herba Scutellariae Barbatae 2 parts, Folium Eucalypti Robustae 2 parts, Rhizoma Dioscoreae 2 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 1 part, Radix Glycyrrhizae.
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| CN102836313B (en) * | 2011-06-20 | 2014-04-16 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets and preparation method thereof |
| CN102973827B (en) * | 2012-11-22 | 2014-06-18 | 青岛绿曼生物工程有限公司 | Pure Chinese medicine composition for treating piglet yellow-white dysentery, and preparation method thereof |
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