CN103432340A - Chinese herbal medicine oral liquid for treating yellow scours of piglets - Google Patents
Chinese herbal medicine oral liquid for treating yellow scours of piglets Download PDFInfo
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Abstract
The invention relates to a Chinese herbal medicine oral liquid for treating yellow scours of piglets. The Chinese herbal medicine oral liquid is prepared from the following material medicines in parts by weight: 5-6 parts of pomegranate barks, 4-5 parts of wild chrysanthemum flowers, 3-4 parts of smoked plums, 3-4 parts of myrobalan, 2-3 parts of sculellaria barbata, 2-3 parts of eucalyptus robusta, 1-2 parts of Chinese yams, 1-2 parts of white atractylodes rhizomes and 1-2 parts of liquorice. The Chinese herbal medicine oral liquid disclosed by the invention is used for treating yellow scours of piglets, and has the characteristics of low cost, high cure rate, good effect, no toxic and side effects and the like, and is safe and convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet.
Background technology
Yellow scour of piglet is a kind of acute, the height lethal infectious disease of the newborn piglet that caused by Escherichia coli.After escherichia coli enter intestine of young pigs, facility is adsorbed on intestinal mucosa with pili, settles down propagation, produces a large amount of enterotoxins, makes the violent diarrhoea of piglet dehydration.The medicine for the treatment of yellow scour of piglet is much the Antibiotics Western medicine, although have certain therapeutic effect, shortcoming is that Drug resistance is serious.That Chinese herbal medicine has is natural, have no side effect, residual without chemicals, the characteristics such as be difficult for developing immunity to drugs.The Chinese medicine preparation that is used for the treatment of at present yellow scour of piglet is less, and weak effect, and cure rate is low, and the course for the treatment of is long, and cost is high.
Summary of the invention
The object of the invention is to for the problems referred to above, a kind of Chinese herbal medicament oral liquid that can effectively treat yellow scour of piglet is provided.
Technical scheme of the present invention is: a kind of Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet, it is made by the crude drug of following weight parts: Pericarpium Granati 5-6 part, Flos Chrysanthemi Indici 4-5 part, Fructus Mume 3-4 part, Fructus Chebulae 3-4 part, Herba Scutellariae Barbatae 2-3 part, Folium Eucalypti Robustae 2-3 part, Rhizoma Dioscoreae 1-2 part, Rhizoma Atractylodis Macrocephalae 1-2 part, Radix Glycyrrhizae 1-2 part.
The preferred feedstock medicine weight portion of making the Chinese herbal medicament oral liquid that the present invention treats yellow scour of piglet is: 5 parts of Pericarpium Granatis, 5 parts of Flos Chrysanthemi Indicis, 3 parts of Fructus Mumes, 3 parts of Fructus Chebulaes, 2 parts of Herba Scutellariae Barbataes, 2 parts of Folium Eucalypti Robustae, 2 parts of Rhizoma Dioscoreaes, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 1 part, Radix Glycyrrhizae.
In prescription of the present invention, the each component pharmacological effect is:
Pericarpium Granati effect: Pericarpium Granati another name Punica granatum L. shell, Fructus punicae granati skin, sour pomegranate skin, western pomegranate skin etc., sour in the mouth, warm in nature.Return large intestine, lung, kidney channel.The Pericarpium Granati peel is containing tannin, wax, mannitol, phlegmatic temperament, gallic acid, malic acid, pectin and calcium oxalate, natural gum, inulin etc., also containing elaidic acid, Isoquercitrin etc.Experiment in vitro proves that its decoct all has inhibitory action to various bacteria such as escherichia coli.The effect of tool astringing intestine to stop diarrhea, hemostasis, anthelmintic.Multiplex in chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis etc.
The Flos Chrysanthemi Indici effect: Flos Chrysanthemi Indici another name FLOS CHRYSANTHEMI INDICI flower, the bitter heart of a lotus seed, mountain Flos Chrysanthemi, Flos Chrysanthemi etc., cold nature, acrid in the mouth, hardship, return lung, Liver Channel.Flos Chrysanthemi Indici is containing volatile oil, sabinene and cephrol, another containing luteolin glycoside, the red glycoside chrysanthemaxanthin of chrysanthemum, epoxy phylloxanthin, luteolin, Flos Chrysanthemi Indici ketone and chrysanthemol, daucosterol, ambrosin, acacetin, mountain Yu's acid glyceride, Palmic acid etc., escherichia coli etc. are had to inhibitory action.The effect of tool heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.Multiplex in carbuncle, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain etc.
The Fructus Mume effect: Fructus Mume is called dark plum, closes Chinese prunus mume (sieb.) sieb.et zucc., is done a branch prunus mume (sieb.) sieb.et zucc., and property is flat, and sour in the mouth, puckery, return liver, spleen, lung, large intestine channel.The Fructus Mume fruit is containing citric acid, malic acid, oxalic acid, succinic acid and Fumaric acid, also containing 5 hydroxymethyl 2 furaldehyde.Contained volatile component, mainly contain benzaldehyde, benzyl alcohol and hexadecanoic acid.Tool is astringed the lung, astringing intestine to stop diarrhea, the effect of promoting the production of body fluid.For chronic malaria, chronic diarrhea, dysentery, vomiting etc.
Fructus Chebulae's effect: the another name chebule, scold multitude, scold pears, son with the wind.Property is put down, and bitter in the mouth, micro-puckery, return lung, stomach, large intestine channel.Fructus Chebulae's fruit is containing tannin, still containing shikimic acid, dehydroshikimis acid, quininic acid, arabinose etc. and aminoacid, also containing terchebin, tannase, polyphenol oxidase, peroxidase and ascorbic acid oxidase etc.The effect of the grand gasification expectorant of tool, antidiarrheal dysentery.For productive cough incessantly, rush down outward, outer dysentery etc.
The Herba Scutellariae Barbatae effect: Herba Scutellariae Barbatae has another name called narrow leaf Herba Scutellariae indicae, and property is hot, cold, and bitter in the mouth, return lung, liver, kidney channel.The Herba Scutellariae Barbatae herb is containing carthamin, isocarthamidin, high mountain baicalin, the yellow official seal glycoside of high mountain, stearic acid, alkaloid polysaccharide etc.The effect of tool heat-clearing and toxic substances removing, blood stasis dispelling diuresis, for furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice.
The Folium Eucalypti Robustae effect: the young tree of Folium Eucalypti Robustae another name mosquito, Folium Eucalypti Robustae, property is flat, micro-suffering, mildly bitter flavor, GUIXIN, lung, large intestine channel.In Folium Eucalypti Robustae, be separated to robustaol A, robustaol, Robustadial A, Folium Eucalypti Robustae dialdehyde B, Eucalyptus globulus Labill aldehyde etc.The tool dispelling wind is analgesic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic effect.For enteritis, dysentery, skin degerming etc.
The Rhizoma Dioscoreae effect: Rhizoma Dioscoreae another name Rhizomadioscoreae, Rhizoma dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, profit cool in nature, sweet in the mouth, enter lung, spleen, kidney channel.Rhizoma Dioscoreae is containing ruscogenin, polyphenol oxidase, again containing glycoprotein, polysaccharide, cholesterol, various trace elements etc.Tool spleen reinforcing nourishing the stomach, the effect of the lung benefiting that promotes the production of body fluid, for insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, incessant chronic diarrhea etc.
Rhizoma Atractylodis Macrocephalae effect: Rhizoma Atractylodis Macrocephalae another name mountain Ji, Alpinia japonica (Thunb.) Miq., Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, warm in nature, bitter in the mouth, sweet, return spleen, stomach warp.The Rhizoma Atractylodis Macrocephalae contains volatile oil, atractylol, Rhizoma Atractylodis ketone, vitamin A etc.Tool increases the effect of appetite, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic.For insufficiency of the spleen lack of appetite, abdominal distention have loose bowels, edema etc.
The Radix Glycyrrhizae effect: Radix Glycyrrhizae another name Glycyrrhizae, close sweet, close grass, state are old, Herba Hedyotis cantonensis, leather and fur, and property is flat, sweet in the mouth.Return 12 warps.Radix Glycyrrhizae is mainly containing compositions such as glycyrrhizic acids, glycyrrhizin, 24-hydroxyl enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, Angelica Polysaccharide, has antiulcer, promotes pancreatic secretion, protects the liver, the effects such as phagocytic function of blood fat reducing, adjusting macrophage.Glycyrrhizic acid is natural antidote, can be used for body defying age, enhancing immunity, maintains water-electrolyte metabolism balance etc.Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, cushion toxicity, strong.
Prescription foundation of the present invention: yellow scour of piglet is newborn piglet common bacteria disease, after escherichia coli enter intestinal with the piglet suckling, amount reproduction, the violent diarrhoea of piglet dehydration, immunity degradation, the 3rd day is onset peak, the yellow feces of suffering from diarrhoea, and then dehydration is dead, therefore, in treatment, should take anti-inflammation, spleen invigorating dysentery relieving, enhancing immunity is the rule for the treatment of; Pericarpium Granati in prescription, Flos Chrysanthemi Indici, Fructus Chebulae, Herba Scutellariae Barbatae, the antibiotic and bacteriostasis that the Folium Eucalypti Robustae tool is stronger, Pericarpium Granati, Fructus Mume, Fructus Chebulae's astringing intestine to stop diarrhea promote the production of body fluid, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae replenishing QI to invigorate the spleen, raising body's immunity, the sweet temperature QI invigorating of Radix Glycyrrhizae and middle spleen invigorating, current twelve channels and collaterals, coordinating the actions of various ingredients in a prescription; In prescription all medicine phases and, play altogether anti-inflammation, YIN nourishing and the production of body fluid promoting, spleen invigorating dysentery relieving, strengthen the effect of immunologic function, be applicable to treat yellow scour of piglet.
The present invention treats the Chinese herbal medicament oral liquid of yellow scour of piglet, is on the basis of having carried out a large amount of practical applications, according to the traditional medicine ancient prescription, in conjunction with sick of modern popular, the theoretical screening of nosetiology, forms, and yellow scour of piglet is had to good therapeutic effect.
The specific embodiment
The invention will be further described in conjunction with the embodiments.
Embodiment:
1, difference weighting raw materials (decoction pieces), Pericarpium Granati 200 g, Flos Chrysanthemi Indici 200 g, Fructus Mume 120 g, Fructus Chebulae 120 g, Herba Scutellariae Barbatae 80 g, Folium Eucalypti Robustae 80 g, Rhizoma Dioscoreae 80 g, the Rhizoma Atractylodis Macrocephalae 80 g, Radix Glycyrrhizae 40g;
2, the above-mentioned raw materials medicine is ground into respectively to coarse powder;
3, get above-mentioned nine flavor Chinese herbal medicine coarse powder, add after water 8000 mL soak 1h and decoct, water is opened rear slow fire boiling 30min; Filter to obtain first-time filtrate, medicinal residues add water 6000 mL at every turn again and decoct secondary, and each 20min filters and obtains respectively secondary and three filtrates; Merge three times filtrate, be concentrated into approximately 900 mL;
4, by concentrated solution obtained above, add 0.05% sodium benzoate as antiseptic, add water to 1000mL, stir evenly, filter, fill, sterilizing, obtain Chinese herbal medicament oral liquid of the present invention.
Some test situation of utilizing Chinese herbal medicament oral liquid of the present invention to carry out are as follows:
1, Chinese herbal medicament oral liquid of the present invention is to the escherichia coli drug sensitive test
Choose clinical trouble yellow scour of piglet case, through separating, identifying pathogen as escherichia coli O8.Get a certain amount of Chinese herbal medicament oral liquid of the present invention, every mL contains crude drug 1g, sterilizing, and packing, 4 ℃ save backup.The escherichia coli O8 of clinical separation first is inoculated in to flat board, after 37 ℃ of cultivation 18 h, selects colonies typical and be inoculated in 5 mL meat soups, after 37 ℃ of cultivation 18 h, 0.5 Maxwell unit's standard opacity tube, than turbid, is diluted to 10 with meat soup by bacterium liquid
5cFU/mL, standby.
Medicament sensitivity test: adopt the plate punch method, add 1g/mL Chinese herbal medicament oral liquid of the present invention in hole, to fill it up with, overfolw hole is not advisable outward; Choose generally acknowledged to the escherichia coli effect preferably three kinds of antibiotic as the drug sensitive test of ciprofloxacin (1 μ g/mL), amikacin (1 μ g/mL), gentamycin (1 μ g/mL), compare, be placed in 37 ℃ of constant incubators and cultivate 24 h, measure antibacterial circle diameter, the drug sensitive test triplicate of every kind of medicine.Criterion: according to the standard of " pharmacology of Chinese materia medica " and " U.S. clinical laboratory Standardization Research the relevant drug sensitive test standardization of version in 2005 ", be that bacteriostatic diameter >=20 mm are for extremely quick, 20 mm > bacteriostatic diameter >=15 mm are Gao Min, 15 mm > bacteriostatic diameter >=10 mm are quick in being, and 10 mm are following is hypoallergenic.
Chinese herbal medicament oral liquid medicament sensitivity test of the present invention the results are shown in Table 1.
The drug sensitive test of table 1 Chinese herbal medicament oral liquid of the present invention is mm as a result
| Medicine | Escherichia coli O8 |
| Ciprofloxacin | 15.0±0.8 |
| Amikacin | 16.8±0.3 |
| Gentamycin | 17.5±0.5 |
| Chinese herbal medicament oral liquid of the present invention | 22.2±1.0 |
Table 1 demonstration, to escherichia coli O8, Chinese herbal medicament oral liquid of the present invention is for extremely quick, and bacteriostatic diameter reaches 22.2 mm, and ciprofloxacin, amikacin and gentamycin are Gao Min.Drug sensitivity test shows, Chinese herbal medicament oral liquid of the present invention is the most responsive to the inhibitory action of escherichia coli O8, and gentamycin takes second place, and amikacin, ciprofloxacin are slightly inferior, result shows, Chinese herbal medicament oral liquid of the present invention should be as first-selection in the practice for the treatment of yellow scour of piglet.
2, the clinical trial of natural infection yellow scour of piglet
The natural occurrence swinery is provided by Changli County, Hebei province, Luan County, Leting County, Lulong County, each raiser of Funing County respectively, root according to clinical symptoms, cut open that inspection changes, animal inoculation test and laboratory examination results, be diagnosed as yellow scour of piglet.Take and infect separately swinery as test group, the morbidity swinery is pressed the dosage of 10mL/ head, and this Chinese herbal medicament oral liquid is oral, every day 2 times, dispensing 3～5d is a course for the treatment of, after drug withdrawal, continue to observe 3～5d, with clinical symptom disappearance, drinking-water, suckling and the mental status are recovered normal person and are judged to healing, binding of pathological cuts open inspection and takes a sample test result and determine therapeutic effect, the statistics cure rate again.Therapeutic outcome is in Table 2.
The therapeutic effect of table 2 Chinese herbal medicament oral liquid natural infection of the present invention yellow dysentery of piglet pig (unit: head, %)
By the treatment to 129 natural infection yellow scour of piglet piglets, Chinese herbal medicament oral liquid of the present invention has significant therapeutic effect to sick pig, and average cure rate is 84.5%, and generally, through 3～5d transference cure, suckling is normal.
Claims (2)
1. a Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet, is characterized in that it is to be made by the crude drug of following weight parts: Pericarpium Granati 5-6 part, Flos Chrysanthemi Indici 4-5 part, Fructus Mume 3-4 part, Fructus Chebulae 3-4 part, Herba Scutellariae Barbatae 2-3 part, Folium Eucalypti Robustae 2-3 part, Rhizoma Dioscoreae 1-2 part, Rhizoma Atractylodis Macrocephalae 1-2 part, Radix Glycyrrhizae 1-2 part.
2. the Chinese herbal medicament oral liquid for the treatment of yellow scour of piglet according to claim 1, is characterized in that it is to be made by the crude drug of following weight parts: 5 parts of Pericarpium Granatis, 5 parts of Flos Chrysanthemi Indicis, 3 parts of Fructus Mumes, 3 parts of Fructus Chebulaes, 2 parts of Herba Scutellariae Barbataes, 2 parts of Folium Eucalypti Robustae, 2 parts of Rhizoma Dioscoreaes, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 1 part, Radix Glycyrrhizae.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836313A (en) * | 2011-06-20 | 2012-12-26 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets |
| CN102973827A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Pure Chinese medicine composition for treating piglet yellow-white dysentery, and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836313A (en) * | 2011-06-20 | 2012-12-26 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of yellow-white dysentery of piglets |
| CN102973827A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Pure Chinese medicine composition for treating piglet yellow-white dysentery, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 姜聪文: "中药治疗仔猪白痢", 《中药治疗仔猪白痢》 * |
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