CN109248265A - A kind of Chinese medicine composition for treating breast cancer - Google Patents
A kind of Chinese medicine composition for treating breast cancer Download PDFInfo
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- CN109248265A CN109248265A CN201710575830.0A CN201710575830A CN109248265A CN 109248265 A CN109248265 A CN 109248265A CN 201710575830 A CN201710575830 A CN 201710575830A CN 109248265 A CN109248265 A CN 109248265A
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Abstract
Disclosed herein is a kind of Chinese medicine compositions for treating breast cancer, it is characterized in that, bulk pharmaceutical chemicals including following weight: 1-50 parts of turnip, 5-80 parts of myrobalan, 1-20 parts of cayropteris incana, 1-20 parts of Rhizoma Et Radix Notopterygii, 1-20 parts of Lagotis glauca, 1-20 parts of ginseng, 1-20 parts of west safflower, 1-20 parts of seed of pomegranate, 1-20 parts of Tibet inula root, and it is selected from least one of Chinese prickly ash 0.1-10 parts, 0.1-10 parts of muscone.The Chinese medicine composition annexs to cure mainly based on grand, the grand complication of Baconic and adjusts red bar, the grand balance Baconic between, and making just to liquefy is nutrition into each internal organs, tissue and blood, reinvigoration, subdhing swelling and detoxicating.
Description
Technical field
The present invention relates to a kind of Chinese materia medica preparations for treating liver tumour, belong to technical field of traditional Chinese medicines.
Background technique
Breast cancer is one of the most common malignant tumors in women, seriously threatens the physically and mentally healthy of women or even jeopardizes life
Life.The newest cancer statistical data of national cancer institute in 2010 shows that breast cancer occupy American Women's malignant tumour
The death rate first.In China, the especially coastal areas breast cancer such as capital " saliva " Shanghai has become the main evil for endangering WomanHealth
Property tumour.Currently, the treatment of breast cancer is started from surgery alone treatment to reinforcement systemic therapy transformation is focused on, that is, it include surgery hand
Complex treatment including art " chemotherapy ", " radiotherapy ", " endocrine therapy ", " biological therapy " and traditional Chinese medicine.Modern medicine is to cream
The clinical effectiveness of gland cancer is affirmed, but its adverse reaction also can not be ignored.Traditional Chinese medicine is for the effect of comprehensive therapy of breast cancer and excellent
Gesture is increasingly subject to the attention of domestic and international clinical tumor circle.
TCM Document is early to this disease on the books, referred to as " mammary calculus carbuncle ", " newborn infantile malnutrition due to digestive disturbances or intestinalparasites ", " mammary cancer ", " stone milk ", " milk rock " etc.,
Some is quite similar in relation to the description of breast cancer with modern medicine, after be referred in the world this disease used till today for mammary cancer.According to ancient documents
" internal organs imbalance of yin and yang is the inherence basis for suffering from this disease for record, healthy tendency internal weakness;The heresies such as the obstruction of the circulation of vital energy " phlegm is turbid ", " hemostasis ", " heat toxin "
Arrogant the main reason for actually forming this disease.The meridian theory of traditional Chinese medicine is right, and nipple is the punching of liver kidney two warp, and breast is that the bright qi and blood of sun converges
Poly- institute.Therefore mammary cancer morbidity is dirty in close relations with liver and spleen (stomach) two.In modern Chinese medicine, Li Ruiming thinks mammary gland and liver and spleen kidney
Three is dirty in close relations.Liver dredges smooth qi and blood, and emotion regulation coordinates woman's menstruation and mammary gland function.Spleen transporting and transforming nutrients from foodstuff promotes digestion to inhale
It receives, defeated cloth qi-blood-body fluid, nourishes mammary gland.Kidney is referred to as " the congenital foundation ", is the origin of human life activity, hides Kidney-Yin kidney-Yang,
Logical contain rushes wantonly two arteries and veins, has decisive action to the development and its physiological function of uterus and mammary gland.So keeping that liver and spleen kidney three is dirty fills
It is full of and coordinates, improve the ability for resisting exopathogen invasion, three dirty play is made to adjust " the normal work of nourishing and solid protection mammary gland physiological function
With, be prevention and control mammary gland carcinogenesis " development so cure important foundation.Traditional Chinese medicine is in comprehensive therapy of breast cancer
Effect according to the etiology and pathogenesis feature of mammary cancer, modern doctor propose treatment breast cancer preferably use strengthen the body resistance to consolidate the constitution based on " anticancer of getting rid of evils
Supplemented by " focus on harmonizing the liver and spleen principle of reatment.Patient with breast cancer is in peri-operation period, chemicotherapy phase, postoperative consolidation 3 stages
Pathogenic characteristic is different, and good clinical efficacy can be obtained after tcm treatment according to syndrome differentiation.
Tibetanmedicine thinks that human body is made of " grand, red bar, Baconic " three big basis.The root of all diseases is all
The unbalance and disorder of " grand, red bar, Baconic ".Under normal circumstances, grand to occupy bone;Red bar occupy blood, sweat;Baconic, which occupy, to be removed
Other positions except bone, blood, sweat, i.e. essence, muscle, fat, marrow, sperm, stool, urine etc..All kinds of tumours
Therefore disease is also.Tibetan medicine thinks under normal condition that ingested object supports " first liquid ", first liquid nutrition blood, blood battalion
Support soft tissue meat, meat nutrient fat tissue, lipid nutrition bone tissue, osteotrophy marrow.Tumour is formed as between three
Disorder cause ingested object to fail to turn to " first liquid ", and be turned into " dislike liquid " and intravascular enters whole body and respectively organizes, and a certain
The weak position of immunity function is shaken by grand structure element, hard, thin, cold, light, thick reverse action shrinks to build up and disappear for hard difficulty
Lump.This lump Tibetan medicine like as blueness shoulders fruit stone is referred to as " stagnant cancer ", from it is literal it is upper can be translated as " core ", this is i.e. modern to cure
Learn the disease for being referred to as tumour.
Diet essence, blood, meat, fat, bone, marrow, sperm are seven essences for maintaining body.Sperm is white, two kinds red.Tibetan medicine's ancient books and records
Say in " continuous portion ": the essence of white sperm is stored in seminal vesicle, is dispersed throughout whole body in middle arteries upper end maturation.The essence of white essence moistens mother
Body, because without lower row, however turbid turns to milk, and breast increases, and breast increases, baby give birth to after to the preceding food in one's mouth of weaning of growing up
Educate child.Exactly because the generation of breast cancer dislikes liquid and is recycled to the effect of breast and its essence and produces hard difficulty and disappear to lump i.e.
Tumour.
Tibetan medicine thinks the generation of breast cancer, cervical carcinoma, oophoroma, predominantly eating and drinking without temperance and daily life be not normal, virus infection,
Caused by disorder of emotion.Belong to 5 kinds of breast cancer person, belong to 16 kinds of cervical carcinoma person, belongs to 9 kinds of oophoroma person.Breast cancer belongs to hiding
The scope of medicine " arteries and veins ruffian " " wind ruffian ".
Patient's pulse condition string is thin, power is small and micro-, and the arteries and veins of general left and right up and down is unobvious for hollow pulse in addition to micro- existing outer, and ruffian tumor exists
The dirty specific pulse condition at which of each internal organs is unobvious but at a piece of bounce;Go out the point of status such as fish purpose ruffian tumor in urine
Drop;There is different color in up and down before this, be Baconic when having the position white of ruffian tumor, when yellow is red bar, is when red
Blood etc.;Which part of body suffers from ruffian tumor, slightly contamination dirt the upper surface of at this.
Summary of the invention
Based on drawbacks described above, the present invention provides a kind of antitumor Chinese medicine composition, the original including following weight
Expect medicine: 1-50 parts of turnip, 5-80 parts of myrobalan, 1-20 parts of cayropteris incana, 1-20 parts of Rhizoma Et Radix Notopterygii, 1-20 parts of Lagotis glauca, 1-20 parts of ginseng, west
1-20 parts of safflower, 1-20 parts of seed of pomegranate, 1-20 parts of Tibet inula root, and in 0.1-10 parts of Chinese prickly ash, 0.1-10 parts of muscone
At least one.
Preferably include the bulk pharmaceutical chemicals of following weight: 1-50 parts of turnip, 5-80 parts of myrobalan, 1-20 parts of cayropteris incana, Qiang
1-20 parts, 1-20 parts of Lagotis glauca, 1-20 parts of ginseng, 1-20 parts of west safflower, 1-20 parts of seed of pomegranate, 1-20 parts of Tibet inula root, Chinese prickly ash living
0.1-10 parts, 0.1-10 parts of muscone.
Further preferred raw material further includes at least one selected from root of kirilow rhodiola, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae.
Further preferred raw material further includes at least one selected from Prunella vulgaris, prepared RHIZOMA PINELLIZE without adju-vant, dandelion.
Further preferred raw material further includes at least one selected from Rhizoma Acori Calami, emblic.
Chinese medicine composition of the invention preferably includes the bulk pharmaceutical chemicals of following weight: 1-40 parts of turnip, myrobalan 5-60
Part, 1-20 parts of cayropteris incana, 1-15 parts of Rhizoma Et Radix Notopterygii, 1-15 parts of Lagotis glauca, 1-20 parts of ginseng, 1-20 parts of west safflower, 1-15 parts of seed of pomegranate,
1-15 parts of Tibet inula root, 0.1-10 parts of Chinese prickly ash, 0.1-10 parts of muscone.
It further preferably include the bulk pharmaceutical chemicals of following weight: 10-40 parts of turnip, 30-60 parts of myrobalan, cayropteris incana 1-
20 parts, 1-10 parts of Rhizoma Et Radix Notopterygii, 1-10 parts of Lagotis glauca, 1-15 parts of ginseng, 1-15 parts of west safflower, 1-15 parts of seed of pomegranate, Tibet inula root 1-10
Part, 0.1-5 parts of Chinese prickly ash, 0.1-5 parts of muscone.
The present invention also provides a kind of Chinese materia medica preparations, by above-mentioned Chinese medicine composition, and pharmaceutically acceptable auxiliary material system
At.
The present invention also provides a kind of health foods, are made using above-mentioned Chinese medicine composition as one of additive or ingredient.
Chinese medicine composition of the invention is used for application in preparation of anti-tumor drugs, and the tumour is breast cancer.
Side selects its acrid flavour of turnip, warm-natured, and furthermore pungent taste is given birth to by wind fire, has light, rough, sharp, hot, floating, dynamic, dry seven property,
Baconic's disease, grand disease can be controlled.Three because of the invasion of unbalance, exopathogen, dislike liquid production exactly and lead to essence and dislike liquid shrink build up at tumour it
Basic reason.Select myrobalan and ginseng in side.Myrobalan have Six-element, eight property, 17 effect can imitate control 20 attributes disease.Ginseng bitter, puckery, hardship
Taste is born from wind fire, thus has dilute, cool, blunt, soft, light, rough, dynamic seven property, and astringent taste is given birth to by folk song, with cold, blunt, dry, rough, again
Five properties.Two medicines share, and prescription balance three can be assisted because of reinvigoration.
Select cayropteris incana, Rhizoma Et Radix Notopterygii, Lagotis glauca, seed of pomegranate, west safflower, radix jurineae in side.Wherein, seed of pomegranate, radix jurineae, Lan Xiang
Grass, Rhizoma Et Radix Notopterygii be warm-natured, and to assist prescription cold in grand disease to controlling.Having both property of seed of pomegranate profit, can be thin in grand disease to controlling, and can assist
Baconic's disease is treated, stomach sun is promoted, so that food is turned to just liquid rather than dislikes liquid.In side west safflower property again can assisted prescription it is light to controlling,
Furthermore west safflower has both the first body-building of training to effect.
Chinese prickly ash, Lagotis glauca are adjuvant in side.Chinese prickly ash, Lagotis glauca property are rough can be with coordinating the drug actions of a prescription.In addition, Lagotis glauca can heat-clearing
Removing toxic substances promotes the removing for disliking liquid.Two medicines share while having the drug of coordinating the drug actions of a prescription effect.
According to the difference of individual patients constitution and disease specific manifestation, may be selected to increase Prunella vulgaris, prepared RHIZOMA PINELLIZE without adju-vant, dandelion etc.
Medicinal material.Dandelion is cold in nature, bitter, sweet.Return liver warp, stomach meridian have clearing heat and detoxicating, diuresis dissipating bind.Prunella vulgaris is cold in nature, acrid flavour, hardship.
Return liver warp, gallbladder channel are relieved inflammation or internal heat, improving eyesight, dissipating bind, detumescence.Prepared RHIZOMA PINELLIZE without adju-vant is warm-natured, acrid flavour, toxic.Converge to the spleen channel, stomach meridian, lung channel, eliminating dampness
Phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The wet liquid of disliking of the formation of tumour is assembled at a certain position of body, and shrinking accumulation by grand effect is
The lump that hard difficulty disappears.Three taste medical instruments have the effect of dissipating bind, detumescence, removing toxic substances, can assisted prescription eliminate the tumour of tumour or inhibition
Growth.Three taste medicines herein according to circumstances can be added or be added in combination alone.
The effect of to strengthen Chinese medicine composition one aspect, composition provided by the present invention can also be comprising extremely
It is few a kind of selected from root of kirilow rhodiola, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Rhizoma Acori Calami, emblic.Root of kirilow rhodiola has qi and activate blood circulation, promotes blood circulation and relievings asthma.Rhizoma Atractylodis Macrocephalae
Temperature, sweet in flavor, bitter, invigorating the spleen, QI invigorating, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.Rhizoma Acori Calami, emblic, Radix Glycyrrhizae have the effect of helping digestion.More than
Drug has both the effect that tonifying Qi helps digestion can assisted prescription treatment.
It to cure mainly based on grand, the grand complication of Baconic, annexs and adjusts red bar, the grand balance Baconic between, make the just liquefaction be
Nutrition enters each internal organs, tissue and blood, reinvigoration, subdhing swelling and detoxicating.
On the other hand, with Chinese medicine composition provided by the invention, it is suitable pharmaceutically acceptable auxiliary that addition may be selected
Material, can prepare the Chinese materia medica preparation that can adjust immune system, and method can be the Chinese materia medica preparation production method of any conventional,
Produce any conventional dosage form.In view of the compliance and drug effect of patient, the preparation is preferably peroral dosage form, is more preferably dissipated
Agent, capsule, tablet, most preferably tablet.
The method of preparation may is that
1) each raw material chosen it is miscellaneous after, weigh, grouping put well it is spare;
2) each group raw material dissection, pulverizes respectively, crosses No. 2 standard screens;
3) powder is mixed to get the active pharmaceutical ingredient composition;
4) active ingredient compositions that will 3) obtain, by standard preparation process, different according to made dosage form add pharmaceutic adjuvants,
It carries out being processed into preparation.
Such as, it will thus provide the Chinese medicine composition method that is prepared into powder are as follows: the Chinese medicine composition provided, Jiang Geyuan are provided
Material medicine dissection is pulverized, and is mixed up to powder.
For another example by method that the Chinese medicine composition provided is prepared into buccal tablet: by the Chinese medicine composition powder provided with
Prepare the suitable additive of tablet of buccal tablet, such as mannitol, magnesium stearate, dextrin, mixing granulation, whole grain, tabletting to obtain the final product.
It is preferred that powder and buccal tablet is made in the composition provided.In use, the powder or buccal tablet are pressed dosage mark
Standard takes medicine, is placed in sublingual administration, is at least swallowing after five minutes, can drink water within 30 minutes after swallowing.
Preferably, composition dosage of each component used in the present invention are as follows: 1-40 parts of turnip, 5-60 parts of myrobalan, cayropteris incana
1-20 parts, 1-15 parts of Rhizoma Et Radix Notopterygii, 1-15 parts of Lagotis glauca, 1-20 parts of ginseng, 1-20 parts of west safflower, 1-15 parts of seed of pomegranate, Tibet inula root 1-
15 parts, 0.1-10 parts of Chinese prickly ash, 0.1-10 parts of muscone.
It is furthermore preferred that composition dosage of each component used in the present invention are as follows: 10-40 parts of turnip, 30-60 parts of myrobalan, orchid
1-20 parts of vanilla, 1-10 parts of Rhizoma Et Radix Notopterygii, 1-10 parts of Lagotis glauca, 1-15 parts of ginseng, 1-15 parts of west safflower, 1-15 parts of seed of pomegranate, hiding wood
1-10 parts fragrant, 0.1-5 parts of Chinese prickly ash, 0.1-5 parts of muscone.
The Chinese medicine being related in the present invention program is described as follows:
Turnip: alias turnip, Orychophragmus violaceus, circle turnip, circle root, assorted cold dishes, people from northeast claim brassica napobrassica, kohlrabi, and people from Xinjiang claims Qamgur,
Latin literary fame Brassica rapa, Brassica genus Vegetable Crops of Brassica turnip subspecies, can form the biennial herb plant of fleshy root.It is loose
Fleshy root is edible, and fleshy root is tender, fine and close, for stir-frying and eating, cooking.There is cultivation in Europe, Asia and America.Acrid flavour, it is warm-natured, it controls
Baconic's disease, grand disease, red bar raw, preventable disease poison.
Studies have shown that turnip contains following chemical component: saponin(e, flavonoids, carbohydrate and its glycosides, alkaloids, volatilization
Oil, phenols, tannin, amino acid, protein, sitosterol, hexadecane, β-daucosterol, Quercetin, n-dotriacontanol, oil
The fatty acid such as acid, linoleic acid, erucic acid, eicosenoic acid, palmitinic acid and stearic acid, butyl isothiocyanate, allyl isothiocyanate,
Thio glucose glucosides etc..Turnip has effects that related with above-mentioned effective component.
Myrobalan is the ripening fruits of combretaceae myrobalan platymiscium myrobalan (Terminalia chebula Retz.), again
Claim chebule, microtriche myrobalan.Myrobalan has the effect of astringeing the lung to stop cough, relieving diarrhea with astringents, fall fire relieving sore-throat.In Tibetan medicine system, He Ziwei
Most common Tibetan medicine material is regarded as " king of Tibetan medicine ".The fruit 23.60%-37.36% containing tannin of myrobalan, includes: chebulinic acid is scolded
Li Le acid, corilagin, myrobalani-tannin, 2,3-O- connect two nutgall acyl Tannin in Punica granatum L, olive benevolence flavine, terchebin, Portugal
Grape sugar galla turcica tan glucoside, 1,3,6- trigalloylglucose, gallic acid, benzoaric acid etc..Contain triterpenes components: olive again
Benevolence terpene acid, scolds king's alcohol.Also contain shikimic acid, dehydroshikimis acid, quininic acid, 30 carbonic acid, palmitinic acid, gallic acid ester, myrobalan
The ester of hypo acid three, Daucosterol, cupreol, arabinose, fructose, glucose, sucrose, rhamnose and amino acid etc..It is another containing kind
Rush down glucoside, terchebin and tannase, polyphenol oxidase, peroxidase, ascorbic acid oxidase etc..Modern research shows that scolding
Son also has certain anticancer function.
Cayropteris incana is the drying herb of Verbenaceae cayropteris incana Caryopterisincana (Thunb.) Miq..
Acrid flavour, warm-natured, expelling wind to resolve the exterior, dispelling cold and dehumidification, removing blood stasis and acesodyne.Research shows that containing in cayropteris incana: the dilute ether terpene of flavones, ring, steroidal,
The dilute ketone of ring, pyran derivate, Coumarins, cinnamic acid etc., wherein flavonoid quantity is most, there is 6.Respectively angle Hu
Numb glycosides, luteolin-7-glucoside, baicalein -7- glucuronic acid, luteolin, apiolin, robinin etc..
Rhizoma Et Radix Notopterygii is umbelliferae Rhizoma Et Radix Notopterygii Notopterygiumincisum Ting ex H.T.Chang or notopterygium forbesii
The dry rhizome and root of Notopterygium, franchetii H. de Boiss..It is warm-natured, acrid flavour, hardship.Relieving exterior syndrome and dispelling cold is dispelled
Wind dehumidifying, analgesic.Rhizoma Et Radix Notopterygii rhizome compound containing Coumarins, phenoloid, volatile oil (about 2.7%), fatty acid, amino
Acids, carbohydrate, Rhizoma Et Radix Notopterygii also contain phenethyl ferulic acid ester.Under ground portion compound containing Coumarins, the phenol chemical combination of notopterygium forbesii
Object, also glycoside containing cupreol and volatile oil.Separately contain Notopterol, Isomperatorin, different imperatorin, nodakenin
The ingredients such as member, spainulenol, chlorogenic acid, ferulic acid, bergapten.
Lagotis glauca: it is cool in nature, rough, cure mainly colic pain, shouting pain, can removing heat from blood, clearing heat and detoxicating, purify the blood, red bar of dysphoria with smothery sensation.Perennial height
Big draft, root thickness are big, four diamond shape of stem, have glandular hairs, leaf is to life, and the aobvious net knot of veinclearing, it is in coniform, bennet that cyme evacuation, which is carried out,
It is elongated, there are glandular hairs.Calyx lobe top blunt circle, spends small, and mulberry, tube is subsphaeroidal, and staminodium is big and is bordering on circle.Capsule
There is beak at oval, end.Research shows that be not positive ten tetra-carbonic, linoleic acid list glycerolipid,;Mono- paddy of β imprisons alcohol, daucosterol, palmitic acid
Single glycerolipid, succinic acid (vI), reseda (Vll), luteolin 7-O- beta-glucosidase.Lagotis glauca have effects that with it is above-mentioned
Effective component is related.
Ginseng: being herbaceos perennial, and happiness is shady and cool, blade pore-free and palisade tissue, can not retain moisture, and temperature is high
It can burn in 32 degree of blades, canopy density 0.7-0.8.It blooms within usual 3 years, 5-6 annual bearing, the month at florescence 5-6, the fruiting period 6-9 month.Growth
Height above sea level between 33 degree -48 degree of north latitude, hundreds of meters of theropencedrymion based on Korean pine or broad leaved and deciduous broad leaved hayashishita.Bitter,
Puckery, effect controls all viral diseases, pyreticosis, is the king of the medicine of a cold nature.Research shows that active constituent mainly has protopanoxadiol, protoplast in ginseng
Join saponin(e that three pure and mild oleanolic acids are aglycon and other kinds of saponin(e include Losec Di's dragon shape saponin(e and sapogenin skeleton with
The changed saponin(e of side chain.Monomer polysaccharide has galacturonic acidic group, galactosyl, aralino, rhamnopyranosyl.Fatty acid
Including methyl myristate, 5- octadecenic acid methyl esters, pentadecanoic acid methyl esters, palmitoleic acid methyl esters, palmitinic acid first, 1-(+)-anti-
Bad hematic acid -2,6- hexadecane dicarboxylic acid, 3- octyl-Oxyranyle methyl caprylate, methyl margarate, methyl linoleate, oleic acid first
Ester, vaccenic acid methyl esters, methyl stearate, 11- eicosenoic acid methyl esters, Methyl n-docosanoate, tricosanic acid methyl esters, (Z) -15- 24
Carbon enoic acid methyl esters, tetracosanoic acid methyl esters.Volatile oil includes pentadecane, hexadecane, 2,6,10,15- tetramethyl-heptadecane, n-
Hexadecanoic acid, 7,11- dimethyl -3- press methyl-1,12 carbon triolefin of 6,10-, 1,2- benzene dicarboxylic acid di-isooctyl.Ginseng has
The effect of it is related with above-mentioned effective component.
West safflower: west safflower is the drying column cap of Iridaceae crocus plant safflower (Crocus sativus L.),
Crocetin (Crocitin), west safflower aldehyde (safranal), crocin (Crocin) and the west safflower bitter principle contained
(Protocrocin), there is activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization.In addition, modern technologies are studies have shown that west safflower has
Inhibit cancer, adjust immunity, oxidation resistant function.
Seed of pomegranate is the dry seed of Punicaceae plant pomegranate Punicagranatum L..After autumn fruit maturation
Pericarp is removed, is dried.It is reported according to current research, the chemical component in pomegranate is with tannin class, alkaloid, organic acid and flavones
Based on class.Different according to the position of plant, the type and content of chemical component is different.Tannin class chemical combination in seed of pomegranate
Object mainly has 3,3 '-dimethoxy ellagic acids, 3,3 ', 4 '-trimethoxy ellagic acids, 3- methoxyl group ellagic acid, 4,4 '-and methoxy
Base ellagic acid, flavones ingredient mainly have flavones, flavonols, anthocyanidin, flavan-3-alcohol.Unsaturated fatty acids compound contains
There are citric acid, L MALIC ACID, tartaric acid, oxalic acid, quininic acid and succinic acid.Phenolic acid compound has caffeic acid, ferulic acid, green original
Acid, p-Coumaric Acid and o- coumaric acid.Piperidines and pyrrolidine alkaloid include pelletierine, N- methyl pelletierine, pseudopelletierine,
N- acetyl pelletierine, drop pseudopelletierine, 2-(2 '-hydroxypropyl) -1- piperidines, 2-(2 '-allyl) -1- piperidines, hygrine, drop Gu
Beans alkali, sedridine and N- acetyl sedridine.Seed of pomegranate has effects that related with above-mentioned effective component.
Tibet inula root is the root of compositae plant elecampane Inulahelenium L..It is warm-natured, acrid flavour, hardship, strengthening the spleen and stomach, regulating the qi flowing in the channels solution
Strongly fragrant, analgesic tocolysis.Research shows that Tibet inula root contains volatile oil 1%~3%, synanthrin about 40%, main component is alantolactone in oil,
Furthermore contain isoalantolactone and triterpenes components.Aerial part is containing dioxygen for big window ox lactone and A Luofa Alpha-hydroxy lactone.
Chinese prickly ash: the mature pericarp of rutaceae Chinese prickly ash Zanthoxylumbungeanum Maxim..Acrid flavour, property is rough, controls
Grand disease enters the heart, for the top grade medicine for train of thought of relaxing.Containing volatile oil, contain limonene, cumic alcohol, Geraniol etc. in oil.Pharmacological evaluation table
Bright, pericarp injection has analgesic, anesthetic effect;Geraniol can cause intestine in vitro to be wriggled in a small amount, largely then be allowed to inhibit;Water
Decoction is to streptococcus, staphylococcus, pneumococcus, bacillus anthracis, hay bacillus, comma bacillus, paratyphosum Bacterium and green pus bar
Bacterium has inhibiting effect.
Muscone: contain muskone, and contain muscopyridine, 11 kinds of androstane derivatives, still alcohols containing cholesteric, fat, albumen
Matter, wax and inorganic salts.Experiment shows that this product has stimulating central nervous system and revival effect, can excited breathing, acceleration heartbeat, raising
Blood pressure;Can increase effect of the adrenaline to beta receptor, and have it is cool in nature to β-catecholamine increasing action, removing toxic substances control worm
The effects of disease, resuscitation with aromatics, degrading the channel, swelling and pain relieving.
Root of kirilow rhodiola is crassulaceae plants rhodiola Rhodiolacrenulata Hook .f.et.Thoms.)
H.Ohba dries root and rhizome.Autumn excavation, removes rough bark, dries.It is sweet, bitter, puckery;It is cold.Promoting blood circulation, clearing lung-heat, cough-relieving antipyretic analgesic.
For cured degree (altitude effect), nausea, vomiting, lip and the palm of the hand etc. are blue, and general weakness is uncomfortable in chest, it is difficult to and it is ventilative, it is in poor health
Equal diseases.Research shows that the effective component of root of kirilow rhodiola is rhodioside, root of kirilow rhodiola aglycon network alcohol, Rosavin, benzhydryl hexahydro pyrrole
Pyridine, rhodiola essence and 21 kinds of microelements and 18 kinds of amino acid, amino acid include 7 kinds of essential amino acids.Root of kirilow rhodiola tool
The effect of having, is related with above-mentioned effective component.
Dandelion is the whole herb with root of compositae plant dandelion Taraxacummongolicum Hand.-Mazz..Property
It is cold, bitter, sweet, clearing heat and detoxicating, diuresis dissipating bind.Research shows that dandelion mainly contains taraxasterol, choline, synanthrin and pectin
Deng.Injection in vitro has stronger bactericidal effect to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus, to pneumonia
Diplococcus, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, typhoid bacillus and micrococcus catarrhalis also have
Certain bactericidal effect.Toxicity: small white mouse be injected intravenously Dandelion Injectable Solution LDso be (58.88 ±;7.94) g kg,
Mouse, rabbit subacute toxicity test may occur in which a small amount of cast to kidney, and renal cells cloudy swelling ribbon, decoction is to rat mouthful
Clothes absorb well, certain antibacterial action are able to maintain in urine.
Prepared RHIZOMA PINELLIZE without adju-vant: also known as the clear water tuber of pinellia, clear summer, clear summer piece.For the person of being used as medicine after dried pinellia alum Processing methods.Prepared RHIZOMA PINELLIZE without adju-vant
Toxicity and pungent dry property reduce, and resolve phlegm effect enhancing is preferably used for weak more phlegm, cold-dampness compared with less serious case.Containing volatile oil, 3- acetyl is included
60 Multiple components such as amino -5- methyl isoxazole and 16 kinds of amino acid and a variety of inorganic elements.Wherein, contained needle-like calcium oxalate crystal is
One of stimulating component of the tuber of pinellia, after processing, crystalline form changes, and content sharply declines, and irritation obviously weakens.Separately contain amber
Amber acid, butyl vinyl ether, benzaldehyde, pinellin, the peppery alcohol of ginger, trypsin inhibitor etc..Prepared RHIZOMA PINELLIZE without adju-vant have effects that with
Above-mentioned effective component is related.
Rhizoma Acori Calami is the dry rhizome of aroid Rhizoma Acori Calami (Acoruscalamus L.), has warm stomach, anti-inflammatory
The effect of analgesic.Rhizoma Acori Calami is also known as rhizoma calami, calamus, smelly Pu, mud calamus, big calamus.Rhizoma Acori Calami complete stool containing it is a variety of effectively at
Point, rhizome contains volatile oil, and main component is α-asarone, beta-Asarone in oil, and volatile oil is also contained at other positions of herb.Separately
Still contain vitamin, palmitinic acid, acorin fatty acid mixed and sugar.Modern pharmacology test result shows that Rhizoma Acori Calami has tranquilizing the mind town
The effects of quiet, anticonvulsion and cooling.In addition, still there is the pharmacological actions such as solution smooth muscle spasm.
Emblic: (medicine is commonly used to the ripening fruits of euphorbia plant emblic Phyllan-thus emblica L. by Tibetan
Material).It is cool in nature, it is sweet in flavor, sour, puckery.Distributed in lung channel, stomach meridian.Clearing heat and cooling blood, food digesting stomach fortifying, cough-relieving of promoting the production of body fluid.Containing tannin, wherein there is grape
Sugared galla turcica tan glucoside, gallic acid, benzoaric acid, corilagin, terchebin, Chebulagic acid, chebulinic acid, He Zici
Acid, 3,6- digalloylglucoses, dry fruit 4%-9% containing glactaric acid.Pericarp contains gallic acid, phyllemblic acid, emblic phenol.Seed contains
Fixing oil about 26%, oil in contain linolenic acid 8.8%, linoleic acid 44%, 28.4 % of oleic acid, stearic acid 2.2%, palmitinic acid 3.0%, Pork and beans
Cool sour 1% etc..Emblic has effects that related with above-mentioned effective component in prescription.
Specific embodiment
The present invention is further illustrated below by way of several embodiments.It should be appreciated that cited all embodiments are side
It helps those skilled in the art understand that with the present invention, not any type of any limitation of the invention is implemented.All are in this hair
The simple modifications and adjustment carried out on the basis of bright, and raw material therein is carried out to equivalent or equivalent replacement, and fail to generate
New substantive distinguishing features and marked improvement, it should all be within protection scope of the present invention.
1 composition prescription example of embodiment
Several example prescriptions are given below, and indicate each prescription scope of application and object.It is noted that listed prescription is not
The restriction of any pair of composition, only concrete example purposes of discussion.The card that those skilled in the art can show according to disease
Shape is different, and the constitution difference of patient is adjusted prescription, these adjustment should be equally included within protection scope of the present invention.
Prescription 1
Turnip: 50g myrobalan: 90g cayropteris incana: 5g Rhizoma Et Radix Notopterygii: 2.5g
Lagotis glauca: 2.5g ginseng: 10g west safflower: 2.5g seed of pomegranate: 5g
Tibet inula root: 2.5g Chinese prickly ash: 1.45g muscone: 0.35g
Prescription 2
Turnip: 17g myrobalan: 85g cayropteris incana: 17g Rhizoma Et Radix Notopterygii: 17g
Lagotis glauca: 17g ginseng: 17g west safflower: 17g seed of pomegranate: 17g
Tibet inula root: g Chinese prickly ash: g muscone: 0.35g
Prescription 3
Turnip: 85g myrobalan: 137g cayropteris incana: 34g Rhizoma Et Radix Notopterygii: 34g
Lagotis glauca: 34g ginseng: 34g west safflower: 34g seed of pomegranate: 34g
Tibet inula root: 34g Chinese prickly ash: 17g muscone: 17g root of kirilow rhodiola: g
Prunella vulgaris: g Rhizoma Acori Calami: g
Prescription 4
Turnip: 50g myrobalan: 90g cayropteris incana: 5g Rhizoma Et Radix Notopterygii: 2.5g
Lagotis glauca: 2.5g ginseng: 10g west safflower: 2.5g seed of pomegranate: 5g
Tibet inula root: 2.5g Chinese prickly ash: 1.45g muscone: 0.35g root of kirilow rhodiola: 10g
Prunella vulgaris: 15g Rhizoma Acori Calami: 20g
Prescription 5
Turnip: 50g myrobalan: 90g cayropteris incana: 5g Rhizoma Et Radix Notopterygii: 2.5g
Lagotis glauca: 2.5g ginseng: 10g west safflower: 2.5g seed of pomegranate: 5g
Tibet inula root: 2.5g Chinese prickly ash: 1.45g muscone: 0.35g Rhizoma Atractylodis Macrocephalae: 6g
Prepared RHIZOMA PINELLIZE without adju-vant: 10g emblic: 17g
Prescription 6
Turnip: 50g myrobalan: 90g cayropteris incana: 5g Rhizoma Et Radix Notopterygii: 2.5g
Lagotis glauca: 2.5g ginseng: 10g west safflower: 2.5g seed of pomegranate: 5g
Tibet inula root: 2.5g Chinese prickly ash: 1.45g muscone: 0.35g Radix Glycyrrhizae: 8g
Dandelion: 9g Rhizoma Acori Calami: 22g
The external pharmacological evaluation of experimental example 1
It is 1 × 10 that eugonic MCF-7 cell, which is used the DMEM culture medium adjustment concentration containing 10% fetal calf serum,7The cell of/mL
Liquid, it is subcutaneous to be only inoculated in armpit on the right side of nude mice by 0.2ml/, observes the growing state of knurl.When tumor volume > 100mm3, survey
The length (a, mm) and width (b, mm) for measuring knurl select tumour growth vigorous and tumor bearing nude mice without ulceration by tumor volume is calculated,
It puts to death animal and aseptically removes knurl with 75% alcohol disinfecting animal knurl surface and surrounding skin, with 0.9% chlorination
Sodium injection is with 1:1(V:V) ratio be made viable count be 107The knurl tissue homogenate of/mL is inoculated in the normal nude mice right side
Under the armpit of side, every animal inoculation pvaccination 0.2mL observes the growing state of knurl, to tumor volume > 100mm3When, same treatment behaviour
Passage inoculation is carried out, is operated by the same method with the knurl tissue homogenate for reaching 2 generations or more and is inoculated in the formal experiment nude mice right side
Side oxter.
Taking tumor volume is 100mm3Above nude mice is grouped at random by tumor volume, and every group 10, experiment sets model pair
According to group, positive controls, prescription group, by 20mL/kg gastric infusion, 1 times/day, continuous 28 days.Animal is observed during test daily
Diet, drinking-water, behavioral activity and knurl situation, measure and record within every 5 days the length and width and the weight of animals of knurl, experiment knot
Animal is put to death when beam, is removed knurl, is weighed and take pictures.
Gross tumor volume and Relative tumor proliferation rate: using the length and width of vernier caliper measurement tumour, gross tumor volume T is calculatedV =
1/2×a×b2(length and width that a, b respectively indicate tumour) calculates relative tumour volume (RTV), RTV according to measurement result
= Vt / V0(V0For pre-neoplastic volume, V is administeredtFor the gross tumor volume measured each time);Antitumor activity evaluation index is phase
To tumor proliferation rate.
The standard of curative effect evaluation:(TRTV is treatment group RTV, and CRTV is negative control group RTV)
The % of T/C % > 40 is invalid;T/C %≤40% and to be statistically analyzed P < 0.05 be effective.
The standard of curative effect evaluation: inhibition rate of tumor growth < 40% is invalid;Inhibition rate of tumor growth >=40% and through statistics at
It is effective for managing P < 0.05.
From experimental result it can be concluded that, by with set up blank control group and positive drug control group and set up with drug of the invention
Experimental group compare experiment.The number of animals of administration group tumor control rate of the invention greater than 40% is significantly more than positive control
Group and blank administration group, it was demonstrated that drug has apparent inhibiting effect to the proliferation of tumour cell.
Embodiment 2
Treatment method: it is buccal, once a day, one time 4, a month as a course for the treatment of.
Curative effect judging standard:
Cure: symptom all disappears, and does not recur within 2 years or more;
Effective: the disappearance or substantially reduced of affected area pain, CT show that affected area tumour is obviously reduced;
Effective: affected area pain relief, CT show that affected area tumour does not continue to increase, other positions have no new tumour;
Invalid: affected area pain is not alleviated, and tumour continues to increase or shift.
Case 1
Patient Hu, female, 47 years old.In July, 2013 is diagnosed as breast cancer.Come here, receives prescription 6 of the present invention and treat 3
After month, review result is shown, the volume of lump is obviously reduced.It survives nearly 3 years time with tumor at present.
Claims (10)
1. a kind of Chinese medicine composition for treating breast cancer, which is characterized in that the bulk pharmaceutical chemicals including following weight: turnip 1-
50 parts, 5-80 parts of myrobalan, 1-20 parts of cayropteris incana, 1-20 parts of Rhizoma Et Radix Notopterygii, 1-20 parts of Lagotis glauca, 1-20 parts of ginseng, 1-20 parts of west safflower,
1-20 parts of seed of pomegranate, 1-20 parts of Tibet inula root, and it is selected from least one of Chinese prickly ash 0.1-10 parts, 0.1-10 parts of muscone.
2. Chinese medicine composition according to claim 1, which is characterized in that the bulk pharmaceutical chemicals including following weight:: turnip 1-
50 parts, 5-80 parts of myrobalan, 1-20 parts of cayropteris incana, 1-20 parts of Rhizoma Et Radix Notopterygii, 1-20 parts of Lagotis glauca, 1-20 parts of ginseng, 1-20 parts of west safflower,
1-20 parts of seed of pomegranate, 1-20 parts of Tibet inula root, 0.1-10 parts of Chinese prickly ash, 0.1-10 parts of muscone.
3. according to claim 1-2 it is one of any described in Chinese medicine composition, which is characterized in that raw material further includes at least one choosing
From root of kirilow rhodiola, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae.
4. according to claim 1-2 it is one of any described in Chinese medicine composition, which is characterized in that raw material further includes at least one choosing
From Prunella vulgaris, prepared RHIZOMA PINELLIZE without adju-vant, dandelion.
5. according to claim 1-2 it is one of any described in Chinese medicine composition, which is characterized in that raw material further includes at least one choosing
From Rhizoma Acori Calami, emblic.
6. according to claim 1-2 it is one of any described in Chinese medicine composition, which is characterized in that including following weight
Bulk pharmaceutical chemicals: 1-40 parts of turnip, 5-60 parts of myrobalan, 1-20 parts of cayropteris incana, 1-15 parts of Rhizoma Et Radix Notopterygii, 1-15 parts of Lagotis glauca, 1-20 parts of ginseng,
1-20 parts of west safflower, 1-15 parts of seed of pomegranate, 1-15 parts of Tibet inula root, 0.1-10 parts of Chinese prickly ash, 0.1-10 parts of muscone.
7. according to claim 1-2 it is one of any described in Chinese medicine composition, which is characterized in that including following weight
Bulk pharmaceutical chemicals: 10-40 parts of turnip, 30-60 parts of myrobalan, 1-20 parts of cayropteris incana, 1-10 parts of Rhizoma Et Radix Notopterygii, 1-10 parts of Lagotis glauca, ginseng 1-15
Part, 1-15 parts of west safflower, 1-15 parts of seed of pomegranate, 1-10 parts of Tibet inula root, 0.1-5 parts of Chinese prickly ash, 0.1-5 parts of muscone.
8. a kind of Chinese materia medica preparation, which is characterized in that the composition provided by claim 1-2 any one, and pharmaceutically may be used
It is made with the auxiliary material of receiving.
9. a kind of health food, it is characterised in that the composition that claim 1-2 any one is provided, as additive or at
/ mono- is made.
10. Chinese medicine composition application in preparation of anti-tumor drugs described in -7 any one according to claim 1, feature
It is, the tumour is breast cancer.
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CN111686159A (en) * | 2019-06-28 | 2020-09-22 | 广西壮族自治区花红药业股份有限公司 | New application of malus asiatica composition preparation in preparation of anti-breast cancer drugs |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1399979A (en) * | 2001-07-30 | 2003-03-05 | 张官锁 | Chinese medicine composition for curing cancers |
CN103127482A (en) * | 2012-11-29 | 2013-06-05 | 广西东兴市创新特色医药科技发展有限公司 | Medicine for treating cancer and preparation method thereof |
CN105250675A (en) * | 2015-11-17 | 2016-01-20 | 浏阳市利美免疫力修复中心有限公司 | Traditional Chinese medicine combination for preparing medicine for treating tumour and leukemia |
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2017
- 2017-07-14 CN CN201710575830.0A patent/CN109248265A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1399979A (en) * | 2001-07-30 | 2003-03-05 | 张官锁 | Chinese medicine composition for curing cancers |
CN103127482A (en) * | 2012-11-29 | 2013-06-05 | 广西东兴市创新特色医药科技发展有限公司 | Medicine for treating cancer and preparation method thereof |
CN105250675A (en) * | 2015-11-17 | 2016-01-20 | 浏阳市利美免疫力修复中心有限公司 | Traditional Chinese medicine combination for preparing medicine for treating tumour and leukemia |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111686159A (en) * | 2019-06-28 | 2020-09-22 | 广西壮族自治区花红药业股份有限公司 | New application of malus asiatica composition preparation in preparation of anti-breast cancer drugs |
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