KR100885480B1 - Herb medicine whitening composition and preparing method thereof - Google Patents

Abstract

The present invention relates to a herbal whitening composition and a method for producing the same. The whitening composition of the present invention comprises 20 to 30% by weight, licorice 5 to 15% by weight, motherwort 5 to 15% by weight, mulberry leaves 20 to 30% by weight, and mulberry root 10 to 20% by weight, the present invention The whitening composition of the method is prepared by naturally fermenting licorice for 25 to 35 days at 25 ~ 35 ℃ temperature fermented licorice, fermented lactic acid bacteria in 35 ~ 37 ℃ MRS medium fermented Lactobacillus fermented for 2-3 days Prepare the fermented Lactobacillus Lactobacillus, natural fermentation of mulberry leaves at 25 ~ 35 ℃ temperature for 40 to 50 days to prepare a naturally fermented licorice, and fermented mulberry root at 25 ~ 35 ℃ temperature for 40 to 50 days Prepare naturally fermented mulberry root, 20 to 30% by weight of naturally fermented licorice, 5 to 15% by weight of lactic acid bacteria fermentation, 5 to 15% by weight of motherwort, 20 to 30% by weight of naturally fermented mulberry leaves and naturally fermented mulberry Characterized in that the root is prepared by mixing 10 to 20% by weight It is done.

Herbal whitening composition of the present invention by applying a fermentation engineering technique of the herbal material by natural fermentation or lactic acid bacteria so that each component contains a large amount of useful substances not only excellent antioxidant and whitening effect but also high content of phenolic compounds.

Licorice, Angelica, Motherwort, Mulberry Leaf, Mulberry Root, Antioxidant, Whitening, Phenolic Compound

Description

Herbal whitening composition and its manufacturing method {HERB MEDICINE WHITENING COMPOSITION AND PREPARING METHOD THEREOF}

The present invention relates to a herbal whitening composition, and more particularly to a herbal whitening composition excellent in skin whitening and anti-aging using licorice, Angelica, motherwort, mulberry leaves and mulberry root.

Whitening is one of the most caring parts of women's skin care, and clean and beautiful skin is the envy of all women. It is also the desire of most women to maintain skin that is naturally aging in their mid-20s until they age.

When the skin is exposed to UV rays, the activity of an enzyme called tyrosinase in melanocytes in the basal layer increases, and this enzyme acts on tyrosine, a type of amino acid present in skin tissue, to generate waveguides. As it turns back into dopaquinone, it forms melanin, which causes skin pigmentation, and the skin turns black.

Therefore, skin whitening is required to reduce the activity of tyrosinase, which affects the formation of melanin pigment.

In addition, as oxygen entered into the body during the respiration process is used in the oxidation process, free radicals are generated in various metabolic processes, which cause oxidative power to damage cells. In particular, it is known that this active oxygen is the cause of various diseases and aging, and attention has recently been focused on the cosmetics having an antioxidant effect and development thereof has been made.

However, in order to whiten the tyrosinase activity or whitening to increase the antioxidant ability to prevent skin aging, most artificial chemicals have to be administered to cosmetics, and when applied to the skin for a long time, there was a problem in stability.

Therefore, the development of commercialized products using natural materials has been continued from the existing artificial chemicals-oriented raw materials, but the situation has not obtained satisfactory whitening and antioxidant effects.

In addition, recently, it is known that phenolic compounds have an antioxidant function, and research on this continues. Phenolic compounds interfere with platelet aggregation and act as antioxidants, which reduce coronary and cerebral atherosclerosis, reduce blood clots due to platelet aggregation in narrowed arteries, and are known to be effective in various degenerative adult diseases. Therefore, even in the whitening composition, it will be important to prepare the whitening composition under conditions that can contain the maximum possible phenolic compound.

The inventors of the present invention have studied carefully, and as a result, fermented natural herbs licorice, Angelica ear, motherwort, mulberry leaves, mulberry root to effect whitening and aging as well as to complete the whitening composition containing a large amount of phenolic compounds The present invention has been reached.

It is an object of the present invention to provide a whitening composition which can enhance the antioxidant effect by containing a large amount of phenolic compounds as well as antioxidant function and whitening function from herbal natural plants.

Another object of the present invention is to provide a method for preparing a whitening composition which can enhance the antioxidant effect by containing a large amount of phenolic compounds as well as antioxidant function and whitening function.

The whitening composition of the present invention comprises licorice, Angelica, motherwort, mulberry leaf and mulberry root, 20 to 30% by weight, licorice 5 to 15% by weight, motherwort 5 to 15% by weight, mulberry leaf 20 to 30% by weight relative to the total weight of the composition %, And 10 to 20% by weight of mulberry root.

Herbal whitening composition production method of the present invention, by natural fermentation licorice at 25 ~ 35 ℃ temperature for 30 to 45 days to prepare a natural fermented licorice, lactic acid bacteria inoculated lactic acid bacteria in 35 ~ 37 ℃ MRS medium 2 Prepare fermented Angelica Lactobacillus by fermentation for 3 days, fermented mulberry leaves for 40-50 days at 25 ~ 35 ℃ temperature to prepare naturally fermented licorice, and 40-50 days at 25 ~ 35 ℃ temperature Fermented naturally during the preparation of the naturally fermented mulberry root, 20 to 30% by weight of naturally fermented licorice, 5 to 15% by weight of lactic acid bacteria fermentation, 5 to 15% by weight of motherwort, 20 to 30% by weight of naturally fermented mulberry leaf and It is characterized by being prepared by mixing 10 to 20% by weight of naturally fermented mulberry root.

Herbal whitening composition of the present invention by applying a fermentation engineering technique of the herbal material by natural fermentation or lactic acid bacteria so that each component contains a large amount of useful substances not only excellent antioxidant and whitening effect but also high content of phenolic compounds.

First, the properties of each component of the whitening composition of the present invention will be examined.

Licorice mainly used as a medicinal herb is Glycyrrhiza uralensis Fisch., A perennial herb, and Glycyrrhiza. inflata Bat.). Originally, licorice is a grass native to the central and southern Mediterranean, Russia, the Middle East, and Southeast Asia. It is the most widely used herb throughout the world.

Licorice is sweet in taste and flat in nature. It is good for detoxification of toxic substances, helps weak stomach function, stops coughing and calms the mind. Licorice mainly uses root as a medicinal herb, mainly composed of fructose and saponin called glycyrrhizin. Glycyrrhizin, a licorice component, interferes with the action of certain enzymes (11 beta-hydroxylase) and prevents the breakdown of steroid hormones, resulting in the same effects as steroid hormones, such as a better taste and better body condition.

 The useful part when using licorice is the root, and the light is yellow and sweet. It contains Ghiquiricin, Glucuronic Acid, Glycyrrhizic Acid, Glycyrrhizin, etc. In addition to detoxification and mating action, Jinhae action and expectorant action. Among the components, glycyrrhizinic acid is anti-inflammatory by promoting hemolytic action, that is, anti-allergic action, NK cell activation action, and inteferon release. It also acts as an antiulcer that inhibits gastric acid secretion and protects the gastric mucosa.

Licorice not only sweetens bitter medicine to make it easy to eat, but also has its unique weakness, which antagonizes various polar and toxic drugs to treat drug poisoning caused by extreme medicine or poison, and neutralize and detoxify the poison caused by bacteria. It works. In other words, because all the drugs to release the neutralization and relieve action is an indispensable potion in herbal medicine. In addition to pleurisy and pulmonary tuberculosis, there is a clear treatment effect, such as anterior pituitary insufficiency, Edison's disease, epidemic hepatitis, bronchial asthma, dermatitis (e.g., rash, eczema, acne, freckles), acupuncture, frostbite, limbs, etc. You may also see a therapeutic effect.

Angelica is a perennial herbaceous with Angelica sinensis (Oliv.) Diels.). The name of the herbal medicine is tongdang, and the names of donkey, donggam choong, singamchae, Joseon tang, shingamcho, chamdang ear root, and sungomcho root are other names. Angelica prefers a cool, humid climate, grows well in relatively humid mountains and cold areas, and has a very good aroma of roots. The components of Angelica volatile oil are contained. The main ingredients are butylidene phthalide, n- valerophenone- o- carboxylic acid, and fatty oils and vitamins.

As a pharmacological action of the Angelica, it controls the uterine excitement and inhibition, promotes protein synthesis, prevents vitamin E deficiency and prevents miscarriage. In addition, it promotes blood flow in coronary arteries, stimulates red blood cell production, has anti-inflammatory analgesic effect and non-specific immunostimulating action, thus enhancing the phagocytosis of monocytes. Angelica also has antioxidant and anti-radioactive effects, effective for bronchial asthma, protects liver function and inhibits the growth of various types of bacteria. In particular, polysaccharides contained in Angelica gigas are considered to be antitumor agents because they have immunopharmacological activity, and are known to be used as growth inhibitory drugs against cancer.

Angelica is a representative blood donor, especially for wives, a covenant herb. Angelica means that the blood is returned to its place when the disease occurs due to confusion of the Gi and blood in the human body. The taste of donkey is spicy and written to get the energy of the earth. It has a warm nature and acts like anger of the heart. As such, although Angelica is a single thing, it has both properties of number and anger, and it is known that it is very similar to the principle of blood production in the human body.

Angelica is known to be effective in cold limbs and lower back, menstrual disorders, menstrual pain, hysteria, menopausal disorders, headache, anemia. In addition, it strengthens the uterus and promotes the body's metabolism and endocrine function, as well as improves blood circulation, so it is good for people with weak constitutions, poor pregnancy or people with weak heart. Dongguk is said to always eat tea to lighten the body, stabilize the mind, and live long. Laxative action is also effective in treating constipation and lowers blood sugar levels of diabetes.

Motherwort sibiricus L.) is a biennial herb of the dicotyledon plant and the moss plant. The seed of motherwort is called loyalty. Motherwort is slightly cold, nonpoisonous, tastes bitter. Motherwort contains several types of alkaloids including leonurine, stachydrine, leonuridine, leonurinine, 0leic acid and vitamin A. Motherwort is a drug commonly used for gynecological diseases, and has a physiological control effect such as menstrual disorders and dysmenorrhea, and is known to have an excellent response to uterine contraction while removing bleeding during postpartum uterine contraction or bleeding or abdominal pain. It is also good for edema due to diuretic effect, and leonurine is a guanidin compound, which is effective in lowering blood sugar by affecting glucose metabolism. It is also effective in eczema and itching, increasing blood flow to the heart and coronary arteries, respiratory excitability, and tuberculosis and eyelids. ,

Morus alba L., mulberry) are native to Korea and cultivated, and the mulberry leaves have been used for sheep feed and food since ancient times (Ahn Hak-ju et al., 1982). Herbal medicine has been used as a herbal medicine because it has the effect of lowering blood sugar and lowering blood pressure.

Looking at the composition and functionality of the mulberry leaf through the analysis of modern science, it is analyzed that the mulberry leaf contains about 50 kinds of inorganic components, especially high content of calcium (Ca), iron (Fe), potassium (K), It is rich in vitamins A, B, C and plant fiber, and contains 21 kinds of amino acids such as methionine.

Among the components of the mulberry leaf is the component is found as follows. rutin acts to strengthen blood vessels, γ-GABA acts as a neurotransmitter as a blood pressure lowering substance (鈴木, 1996), and contains moracenin and sanggenone, which are effective in lowering blood pressure. Dimoracin, chalcomoracin, etc. have antibacterial activity on mulberry leaves, and umbelliferone has been shown to be anti-inflammatory. Morusin is an anti-tumor and special ingredient, and DNJ (1-deoxinojirimicin), NN-Me-DNJ, GAL-DNJ, DAB, Calistegin and Fagomine have been shown to be effective in antidiabetic. Rutin, Quercetin, Quercitrin, Isoquercitrin as flavonoid components, as well as 1-deoxynojirimycin with α-glucosidase inhibitory activity as Alkaloid components have been found (Yoshikumi et al., 1994, Oda, 1996). In addition, it is known to be effective in antiallergic, hair loss control, arteriosclerosis, obesity control, etc. It is not yet known which component is due to such efficacy.

Mulberry leaves are known to have a hypoglycemic effect, and also lower and stabilize blood pressure in hypertensive patients, lower triglyceride levels and cholesterol content in blood, and in particular, increase HDL-cholesterol levels and lower harmful LDL-cholesterol levels. Seems. Mulberry leaves have been reported to treat arteriosclerosis, improve blood flow, increase the number of beneficial bacteria in the intestinal bacteria and inhibit aging due to its antioxidant effect. In addition, when the mulberry leaves boil, it is reported that the adsorption of heavy metal dissolved in the water lowers the concentration and helps the extracorporeal discharge of heavy metal in the body. In addition, mulberry leaf extract (X) has a tendency to suppress the mutagenicity of cells and is known to inhibit the increase of cancer cells. In general, mulberry leaves have shown potential as a therapeutic agent while suppressing aging and preventing the occurrence of cultural diseases and various adult diseases of modern adults.

The root bark of the mulberry tree is recorded as a medicinal herb along with the mulberry leaf in the new agricultural plant, the world's first medicine. Sangbaekpi is the most widely used part of mulberry trees as a medicinal herb. Jinhae gumdam is used as a diuretic to stop phlegm and coughing and to urinate well. No toxicity is reported. In addition, fever and astringent symptoms and stool to see the stool to mix well.

Consent of the agreement is, 'Breath of breathing 10 million (喘 滿), breathing heart, panting panic), bleeding dominion ((), soothe the lungs of the lungs, benefits the water, It reigns over the blood that comes out of saliva. '

The epidermis contains a substance that lowers blood pressure, so the experiments using rabbits showed a tendency of lowering blood pressure and a longer duration in proportion to the amount of feeding the epidermis. He also said, 'It leads to the large intestine, eliminates tapeworms, and pulls the thread to sew injured wounds with knives, spears, arrows, etc.' and it is used to cure swelling and to treat phlegm, bronchitis, and asthma.

In addition, baekbaekpi is known to be used in various cosmetic materials as it has excellent moisturizing effect along with melanin suppression and whitening effect, as well as excellent hair growth effect.

In order to investigate the effect of the extract of cypressus on cytarabine-induced alopecia rats, cytarabine (50 mg / kg) was injected into the abdominal cavity daily for 7 days to induce rats with systemic alopecia. After injection, hair extracts were provoked on the dorsal epidermis daily for 12 days. According to the results of the study, there was a study showing that the hair vitalizer containing the extract of E. coli and the extract of E. coli had hair growth and hair loss prevention effects against alopecia induced by cytarabine.

It is known that baekbaekpi contains more than 100 substances, among which the efficacy is known, such as moran A, which lowers blood sugar, and mulberrofuran F, G, which lowers blood pressure. Also, Kuwanon A ~ H (morusinol), Moracin, Demoracin, which kills bacteria in the body and is good for high blood pressure, etc. Morucin (cyclomorusin: a kind of anticancer ingredient) that kills tumors This is known.

In addition, umbelliferone, scopoletin, morusin, mulberin, etc., contains anti-inflammatory and diuretic effect. It also contains amiline (α, β-amyrin), sitosterol, sitosterol-d-glucoside, palmitic acid, stearic acid, adenine, and betaine. . In addition, it contains various substances such as flavonoids that inhibit aging.

Licorice, Angelica, motherwort, mulberry leaf (upper leaf), and mulberry root (upper leaf skin) having the above characteristics are used in the whitening composition of the present invention.

In the whitening composition of the present invention, the content of licorice is preferably 20 to 30% by weight based on the total weight of the composition. If the content of licorice is less than 20% by weight, the active oxygen removal ability is reduced and the antioxidant effect is insufficient, and the content of licorice is 30 If the weight percentage is exceeded, there is a problem in that the content of other components is lowered and the whitening effect is reduced.

In the whitening composition of the present invention, licorice is preferably used which is naturally fermented for 30 to 45 days.

In the whitening composition of the present invention, the content of Angelica is preferably 5 to 15% by weight based on the total weight of the composition. When the content of Angelica is less than 5% by weight, the active oxygen removal ability is lowered and the antioxidant effect is insufficient, and the content of Angelica 15 If the weight percentage is exceeded, there is a problem that the cost increases without the effect of improvement.

Angelica in the whitening composition of the present invention is preferably used for lactic acid bacteria fermentation for 2-3 days.

Lactobacillus which is preferably used when fermenting the Angelica gigas Lactobacillus is Bifidobactarium adoles), Bifidobacterium Infante Tees (Bifidobactarium infantis), Bifidobacterium rongum (Bifidobactarium longum ) And Bifidobactarium ( Bifidobactarium) bifidum ).

In the whitening composition of the present invention, the content of motherwort is preferably 5 to 15% by weight based on the total weight of the composition. When the content of motherwort is less than 5% by weight, the active oxygen removal ability is reduced and the antioxidant effect is insufficient, and the content of motherwort is 15 If the weight percentage is exceeded, there is a problem that the cost increases without the effect of improvement.

In the whitening composition of the present invention, the content of the mulberry leaf is preferably 20 to 30% by weight based on the total weight of the composition. If the content of the mulberry leaf is less than 20% by weight, the active oxygen removal ability is insufficient, and the antioxidant effect is insufficient, and the content of the mulberry leaf is 30 If the weight percentage is exceeded, there is a problem in that the content of other components is lowered and the whitening effect is reduced.

In the whitening composition of the present invention, the mulberry leaf is preferably used for natural fermentation for 40 to 50 days.

In the whitening composition of the present invention, the content of the mulberry root is preferably 10 to 20% by weight based on the total weight of the composition, but if the content of the mulberry root is less than 10% by weight, the whitening effect is insufficient, and the content of the mulberry root is 20% by weight. If it exceeds the amount of other components fall there is a problem that the antioxidant function falls.

In the whitening composition of the present invention, the mulberry root is preferably fermented for 40 to 50 days.

The whitening composition of the present invention can simultaneously satisfy the antioxidant and whitening effect at the same time when licorice, Angelica, motherwort, mulberry leaf and mulberry root are mixed in the above ratio composition, and also considering the ease of obtaining raw materials, economical efficiency, and functionality The optimal mixing ratio is achieved.

In addition, licorice, Angelica, motherwort, mulberry leaf and mulberry root constituting the whitening composition of the present invention can be used, extracting at high temperature by adding water to each raw material, filtered, cooled and concentrated under reduced pressure Is used.

Looking at the method for producing a water-soluble extract of each component, add 10 times the water to each component, extract it at a temperature of 90 ~ 100 ℃, filtered and cooled the solid solution content of 40-50% by weight Concentrate under reduced pressure until the extract is prepared.

Next, the herbal whitening composition manufacturing method of this invention is demonstrated.

First, a constituent material for preparing the herbal whitening composition is prepared.

Licorice is naturally fermented at 25-35 ℃ for 30-45 days.

Angelica first produces a water-soluble extract. 5 ~ 10 times of water was added to Angelica gigas, which was extracted at a temperature of 90 ~ 100 ° C., filtered and cooled, and the extract was concentrated under reduced pressure until the solid content was 40 to 50% by weight. The extract is inoculated with lactic acid bacteria in 35-37 ° C. MRS medium and fermented by lactic acid for 2-3 days to prepare a water-soluble extract. At this time, preferably used lactic acid bacteria Bifidobactarium Adoles ( Bifidobactarium adoles ) , Bifidobactarium infantis ) , Bifidobactarium longum ) And Bifidobactarium bifidum .

In addition, mulberry leaves are prepared by natural fermentation for 40 to 50 days at 25 ~ 35 ℃ temperature.

In addition, mulberry root is prepared by fermenting naturally at 25-35 ° C. for 40-50 days.

On the other hand, motherwort uses what has not been fermented.

20-30% by weight of natural fermented licorice, 5-15% by weight of lactic acid bacteria fermented, 5-15% by weight of motherwort, 20-30% by weight of naturally fermented mulberry leaves and 10-20% by weight of naturally fermented mulberry root To prepare a whitening composition by mixing.

The herbal whitening composition of the present invention may be included in a lotion, cream or pack which is usually prepared, and may be prepared in the form of a lotion, cream or pack.

Hereinafter, the herbal whitening composition of the present invention and its preparation method will be described in more detail with reference to the following examples.

<Example 1>

Licorice was naturally fermented at 30 ° C. for 35 days. 5 times purified water was added to the Angelica extract and the extractor was circulated at 95 ° C. for 24 hours. The extract was filtered twice with 250mesh and cooled. The cooled solution was placed in a vacuum concentrator at 60 ° C. and concentrated under reduced pressure until the solid content was 40-50 wt% to obtain a water-soluble extract of Angelica gigas. Water-soluble extracts of Angelica gigas were extracted from four kinds of lactic acid bacteria ( Bifidobactarium adoles ( Bifidobactarium ) in 37 ℃ MRS (Difco) medium adoles), Bifidobacterium Infante Tees (Bifidobactarium infantis), Bifidobacterium rongum (Bifidobactarium longum ) And Bifidobactarium ( Bifidobactarium) bifidum ) was inoculated and fermented for 2 days. Mulberry leaves were naturally fermented at 30 ° C. for 45 days. Mulberry roots were naturally fermented at 30 ° C. for 45 days. Naturally fermented licorice 280g, lactic acid bacteria fermented Angelica 120g, motherwort powder 120g, natural fermented mulberry leaves 280g and 200g naturally fermented mulberry root was mixed to prepare a herbal whitening composition.

Comparative Example 1

A whitening composition was prepared by mixing 280 g of unfermented licorice powder, 120 g of unfermented Angelica powder, 120 g of unfermented motherwort powder, 280 g of unfermented mulberry leaf, and 200 g of unfermented mulberry root, and mixing 50 g of water.

Test Example 1 Sulfation Activity Test

Each tyrosinase inhibitory activity was measured using the whitening composition prepared in Example 1 and Comparative Example 1 and the results are shown in Table 1.

<Test Example 2> Tyrosinase activity inhibition test

Each tyrosinase inhibitory activity was measured using the whitening composition prepared in Example 1 and Comparative Example 1 and the results are shown in Table 1.

Test Example 3 Total Phenolic Compound Content Test

Each phenolic compound content was measured using the whitening composition prepared in Example 1 and Comparative Example 1 and the results are shown in Table 1.

DPPH radical-scavenging activity (RC ₅₀ , ㎍ / mL) Tyrosinase inhibition activity (% of control) Total phenolic compound contents (㎍ / ㎖) Example 1 342 86.2 126.3 Comparative Example 1 738 47.3 109.2

As can be seen from Table 1, the amount (concentration) of the sample for 50% free radical scavenging ability (RC ₅₀ ) of Example 1 is 0 when the untreated active oxygen scavenging ability without the sample is 0%. 342 µg / ml and Comparative Example 1 were 738 µg / ml. Therefore, the greater the sulfated activity of the sample, the more active oxygen is removed even at low concentration of extract. Therefore, it can be seen that the DPPH radical scavenging activity of the whitening composition of the present invention prepared in Example 1 is larger than that of Comparative Example 1.

In addition, it was found that the whitening composition of the present invention prepared in Example 1 had a higher tyrosinase inhibitory activity than that of Comparative Example 1. Therefore, tyrosinase activity is inhibited and melanin pigment formation is suppressed, resulting in a whitening effect.

In addition, it was found that the whitening composition of the present invention prepared in Example contained more phenolic compounds than Comparative Example 1. Therefore, it can be seen that the whitening composition of Example 1 having a high content of phenolic compound has high antioxidant capacity.

Specific embodiments of the present invention have been presented above, but the present invention is not limited to the above, and various modifications can be made within the technical spirit of the present invention, and such modifications will belong to the following claims.

Claims (4)

20 to 30% by weight of licorice, 5 to 15% by weight, motherwort 5 to 15% by weight, mulberry leaves 20 to 30% by weight and 10 to 20% by weight of mulberry root, The licorice is 30 to 45 days of natural fermentation, the Angelica fermented 2 to 3 days of lactic acid bacteria, the mulberry leaves 40 to 50 days of natural fermentation, the mulberry root 40 to 50 days of fermentation Herbal whitening composition characterized in. delete The method according to claim 1, The lactic acid bacteria is Bifidobacterium Adolfo less (Bifidobactarium adoles), Bifidobacterium Infante tooth (Bifidobactarium infantis), Bifidobacterium rongum (Bifidobactarium longum) And Bifidobactarium bifidum ( Bifidobactarium bifidum ) of the herbal whitening composition. In the method of manufacturing herbal whitening composition, Naturally fermented licorice at 25-35 ℃ temperature for 30-45 days to prepare a naturally fermented licorice, Lactobacillus fermented Lactobacillus was inoculated by lactic acid bacteria inoculated in 35 ~ 37 ℃ MRS medium and fermented for 2-3 days Prepare fermented licorice by naturally fermenting mulberry leaves for 40-50 days at 25 ~ 35 ℃ temperature, Prepare the naturally fermented mulberry root by fermenting the mulberry root naturally for 25-50 days at a temperature of 25-35 ℃, 20 to 30% by weight of the naturally fermented licorice, 5 to 15% by weight of the lactic acid bacteria fermented Angelica, 5 to 15% by weight of motherwort, 20 to 30% by weight of the naturally fermented mulberry leaves and 10 to 20% by weight of the naturally fermented mulberry root Herbal whitening composition manufacturing method characterized in that it is prepared by mixing%.