CN105796715A - Formula of Chinese herbal medicinal composition for treating porcine gastroenteritis diseases and preparation method of Chinese herbal medicinal composition - Google Patents
Formula of Chinese herbal medicinal composition for treating porcine gastroenteritis diseases and preparation method of Chinese herbal medicinal composition Download PDFInfo
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention belongs to formulas and preparation methods of Chinese herbal medicines, and in particular relates to a method for treating porcine gastroenteritis diseases. According to the Chinese herbal medicinal composition for treating the porcine gastroenteritis diseases, the porcine gastroenteritis diseases can be treated through the special material ratio; aiming at the ratio, through the cell wall disruption smashing, the active ingredients in the cells of the Chinese herbal medicinal materials are completely separated and mixed among with the cell wall disruption, thus the curative effects being equivalent to or even exceeding those of the traditional Chinese herbal medicinal decoctions are achieved, and the treatment effects are obvious; the active ingredients in the cells are completely released, so that the use amount of the Chinese herbal medicinal materials can be obviously reduced, further, the cost of the Chinese herbal medicinal composition is reduced, and the effects of the Chinese herbal medicinal composition are as good as the effects obtained when the efficacy is high.
Description
Technical field
The invention belongs to Chinese herbal medicine formula and preparation method thereof, be specifically related to a kind of method treating Gaster Sus domestica enteritis disease.
Background technology
Antibiotic is always up prevention and the main path for the treatment of diarrhea of pigs, and it can suppress the breeding of pathogen to a certain extent, but also can affect the growth of normal flora in intestinal simultaneously, and long-term unconfined use is easily caused by digestive tract disease；Due to antibiotic use lack of standardization, the quantity of Resistant strain is continuously increased, and Drug resistance constantly strengthens, and more seriously the drug residue serious threat in poultry body is to the health of mankind itself.At present, many countries have formulated relevant laws and regulations to limit the antibiotic usage amount of poultry and part is antibiotic prohibits the use of, but do not have.
Summary of the invention
The technical problem to be solved is: the deficiency existed for prior art, there is provided a kind of and utilize modern advanced processing technique of Chinese herbs, in conjunction with the pathogeny of live pig disease, research and develop safe efficient, easy Chinese herbal medicine formula for the treatment of Gaster Sus domestica enteritis disease and preparation method thereof.
For solving above-mentioned technical problem, it is achieved by the following technical solutions:
A kind of herbal composite treating Gaster Sus domestica enteritis disease, compositions consists of Radix Apioris Fortunei (Radix Lespedezae Buergeri) 16-24 part, Radix Bupleuri 8-12 part, Herba Asari 8-12 part, taro Wu's 8-12 part, Radix Angelicae Dahuricae 8-12 part, Rhizoma Atractylodis 8-12 part, dysentery relieving grass 16-24 part, Massa Medicata Fermentata 8-12 part.
Preferably, the method comprises the following steps:
1) mill is kibbled: above herbal composite is ground into through common grinder roughing the powder of 48-52 order, and powder is sufficiently mixed, purpose is that original block material is become powdery, only in this way carry out cell wall breaking again and could fully precipitate out drug effect, find that powder can not grind too thin through experiment, if pulverizer too carefully can remove active substance in grinding process processed, the powder of above-mentioned size is the most accurate in the method；
2) cell wall breaking: mixed semi-finished product are put into cell wall breaking tank, controlling vacuum state in tank to drop under 0.06-0.08 atmospheric pressure, make vaporization fracturing cell walls in mixture, vacuum keeps 4-5 minute, mixture is that cell wall breaking level is pulverized, and pulverizes the superfine powder into 280-320 order；Wherein Radix Apioris Fortunei (Radix Lespedezae Buergeri) etc. are block, and what stem's fiber such as Radix Apioris Fortunei (Radix Lespedezae Buergeri) was many can not do cell wall breaking.
Compared with prior art, the invention has the beneficial effects as follows: special proportioning can treat Gaster Sus domestica enteritis disease；Being pulverized by cell wall breaking level for such proportioning, by the effective ingredient of Chinese herbal medicine cell interior, along with cell wall breaking breaking cellular wall precipitates out fully and mixes, reach to have and exceed the curative effect of Chinese traditional herbs decocting decoction, therapeutic effect is obvious；Wherein the formulation of mixture amount and proportioning, all considering fiber content, can not there is high microsteping containing quantity of material, in order to avoid affecting the effect of cell wall breaking in the compositions of selection；Intracellular effective ingredient filling dilution out, the consumption of Chinese herbal medicine will significantly reduce, and reduce the cost of Chinese herbal medicine, while effect but unlike drug effect height time decrease.
Detailed description of the invention
The following specific embodiments of the present invention is to make a detailed explanation.
Embodiment 1
A kind of herbal composite treating Gaster Sus domestica enteritis disease, compositions consists of Radix Apioris Fortunei (Radix Lespedezae Buergeri) 10g, Radix Bupleuri 5g, Herba Asari 5g, taro Wu 5g, Radix Angelicae Dahuricae 5g, Rhizoma Atractylodis 5g, dysentery relieving grass 10g, Massa Medicata Fermentata 5g.
The preparation method of a kind of herbal composite treating Gaster Sus domestica enteritis disease, the method comprises the following steps:
Composition in above herbal composite is ground into through common grinder roughing the powder of 48 orders, and powder is sufficiently mixed, mixed semi-finished product are put into cell wall breaking tank, control vacuum state in tank and drop under 0.06 atmospheric pressure, make vaporization fracturing cell walls in mixture, vacuum keeps 4 minutes, and mixture is that cell wall breaking level is pulverized, and pulverizing is the 50g superfine powder of 280 orders.The formulation wherein measured and proportioning, all consider fiber content, but the single high microsteping such as Radix Apioris Fortunei (Radix Lespedezae Buergeri) stem can not be put into containing quantity of material, so being all absent from high microsteping containing quantity of material in the compositions selected.
The using method of 50g Chinese herbal medicine is:
The piglet every of ablactational baby pig to 50 jin feeds Chinese herbal medicine 10 grams every day, is used in conjunction 5 days, and just 1 piglet uses.Can preserving more than 12 months under shady and cool dry environment, preservation must be under encapsulation situations, it is impossible to knocking is in air ambient.
Embodiment 2
A kind of herbal composite treating Gaster Sus domestica enteritis disease, compositions consists of Radix Apioris Fortunei (Radix Lespedezae Buergeri) 14g, Radix Bupleuri 7g, Herba Asari 8g, taro Wu 7g, Radix Angelicae Dahuricae 8g, Rhizoma Atractylodis 8g, dysentery relieving grass 15g, Massa Medicata Fermentata 7g.
The preparation method of a kind of herbal composite treating Gaster Sus domestica enteritis disease, the method comprises the following steps:
Composition in above herbal composite is ground into through common grinder roughing the powder of 50 orders, and powder is sufficiently mixed, mixed semi-finished product are put into cell wall breaking tank, control vacuum state in tank and drop under 0.07 atmospheric pressure, make vaporization fracturing cell walls in mixture, vacuum keeps 4 points of halfs, and mixture is that cell wall breaking level is pulverized, and pulverizing is the 75g superfine powder of 300 orders.The formulation wherein measured and proportioning, all consider fiber content, but the single high microsteping such as Radix Apioris Fortunei (Radix Lespedezae Buergeri) stem can not be put into containing quantity of material, so being all absent from high microsteping containing quantity of material in the compositions selected.
The using method of 75g Chinese herbal medicine is: the middle pig of 50 jin to 100 jin feeds Chinese herbal medicine 15 grams every every day, is used in conjunction 5 days, and just 1 piglet uses.Can preserving more than 12 months under shady and cool dry environment, preservation must be under encapsulation situations, it is impossible to knocking is in air ambient.
Embodiment 3
A kind of herbal composite treating Gaster Sus domestica enteritis disease, compositions consists of Radix Apioris Fortunei (Radix Lespedezae Buergeri) 20 parts, Radix Bupleuri 10 parts, Herba Asari 10 parts, taro Wu 10 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Atractylodis 10 parts, dysentery relieving grass 20 parts, Massa Medicata Fermentata 10 parts.
The preparation method of a kind of herbal composite treating Gaster Sus domestica enteritis disease, the method comprises the following steps:
Composition in above herbal composite is ground into through common grinder roughing the powder of 52 orders, and powder is sufficiently mixed, mixed semi-finished product are put into cell wall breaking tank, control vacuum state in tank and drop under 0.08 atmospheric pressure, make vaporization fracturing cell walls in mixture, vacuum keeps 5 minutes, and mixture is that cell wall breaking level is pulverized, and pulverizing is the 1000g superfine powder of 320 orders.The formulation wherein measured and proportioning, all consider fiber content, but the single high microsteping such as Radix Apioris Fortunei (Radix Lespedezae Buergeri) stem can not be put into containing quantity of material, so being all absent from high microsteping containing quantity of material in the compositions selected.
The using method of 100g Chinese herbal medicine is: big pig every hello Chinese herbal medicine 20 grams every day, is used in conjunction 5 days, and just 1 piglet uses.Can preserving more than 12 months under shady and cool dry environment, preservation must be under encapsulation situations, it is impossible to knocking is in air ambient.
Experimental comparison
1, the experiment of superfine powder Chinese herbal medicine toxic and side effects test
Select the three nest piglet 27 of 28 ages in days, be grouped in units of nest, set up matched group, test group 1, test group 2, through the precuring of 2 days, start the interpolation Chinese herbal medicine spice feeding experiment of 7 days by a definite date.Namely test group 1, test group 2 are added the superfine powder Chinese herbal medicine spice of superfine powder Chinese herbal medicine and doubling dosage respectively and are fed 7d, and matched group is even identical without other feeding and management conditions of Chinese herbal medicine, test group and matched group.
Experiment concrete condition is as shown in the table:
Experiments show that, the Chinese herbal medicine of these research and development does not have toxic and side effects, and pig growth and development does not produce harmful effect.
2, the testing experiment of prevention (Gaster Sus domestica enteritis disease) effect of superfine powder Chinese herbal medicine
Select to be susceptible to suffer from season early winter of Gaster Sus domestica enteritis disease, select the piglet 36 that this pig farm 35 age in days is healthy, set up matched group and test group 1, test group 2, namely matched group (blank group) need not add Chinese herbal medicine, and test group 1 group and test group 2 add the superfine powder Chinese herbal medicine of superfine powder Chinese herbal medicine and doubling dosage respectively；In order to ensure medicine Validity Test, experiment divides again 35 ages in days, two stages of 65 age in days to add medication, and it is 5 days that each stage adds administration time, then observes pig growing state.
Experiment concrete condition is as shown in the table:
Test group is added the live pig employing Chinese herbal medicine and is showed active, hair color light, it does not have diarrhoea situation occur, without the matched group using any prophylactic agent, then has a pig a small amount of diarrhoea situation occur.Test shows, this disease of prevention is had certain effect by Chinese veterinary drug preparation.
3, the testing experiment for the treatment of (Gaster Sus domestica enteritis disease) effect of superfine powder Chinese herbal medicine
Selecting to have suffered from the sick pig 12 (selecting age in days suitable, the pig that body weight is close) of Gaster Sus domestica enteritis disease, be divided into two groups, one group uses Western medicine, and Western medicine is purchased from novel chiral synthon shop in Jinyun, and medicine name mequindox injection+enrofloxacin injection is treated, for matched group；Treat with superfine powder Chinese herbal medicine for one group, for test group.Two groups of Contrast on effect experiments carrying out treatment Gaster Sus domestica enteritis disease.Sick pig is during treating, and every sick swine rearing management condition is identical, and every day examines clinical change with taking a broad view of.
Test concrete condition is as shown in the table:
With Chinese herbal treatment Gaster Sus domestica enteritis disease with western medicine Gaster Sus domestica enteritis disease, all there is identical therapeutic effect.Experiment is it is also shown that with the administration time of Chinese herbal treatment to extend with the time compared with Western medicine, but Chinese herbal treatment is less to stress produced by the aspects such as the appetite of pig.
3 embodiments mainly use embodiment 2, and this embodiment can apply to piglets and big pig, and overall proportioning compares balance, by experiment, superfine powder Chinese herbal medicine can be directly added in feedstuff and feed live pig, compared with the administrated method of traditional Chinese herbal medicine, have easy to use, efficient advantage.
Claims (2)
1. the herbal composite treating Gaster Sus domestica enteritis disease, it is characterised in that compositions consists of Radix Apioris Fortunei (Radix Lespedezae Buergeri) 16-24 part, Radix Bupleuri 8-12 part, Herba Asari 8-12 part, taro Wu's 8-12 part, Radix Angelicae Dahuricae 8-12 part, Rhizoma Atractylodis 8-12 part, dysentery relieving grass 16-24 part, Massa Medicata Fermentata 8-12 part.
2. the preparation method of a kind of herbal composite treating Gaster Sus domestica enteritis disease described in claim 1, it is characterised in that the method comprises the following steps:
1) mill is kibbled: above herbal composite is ground into through common grinder roughing the powder of 48-52 order, and is sufficiently mixed by powder；
2) cell wall breaking: mixed semi-finished product are put into cell wall breaking tank, controlling vacuum state in tank to drop under 0.06-0.08 atmospheric pressure, make vaporization fracturing cell walls in mixture, vacuum keeps 4-5 minute, mixture is that cell wall breaking level is pulverized, and pulverizes the superfine powder into 280-320 order.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793137A (en) * | 2017-11-16 | 2019-05-24 | 石继元 | A kind of food and preparation method thereof of white seven classes instant |
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| CN102743657A (en) * | 2012-07-31 | 2012-10-24 | 河南光泰动物药业有限公司 | Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof |
| CN102847017A (en) * | 2012-08-26 | 2013-01-02 | 裔群英 | Oral solution for prevention and treatment of piglet diarrhea, and preparation method thereof |
| CN105053633A (en) * | 2015-07-31 | 2015-11-18 | 无为县金宝生态农业开发有限公司 | Poultry physique improving Chinese herbal medicinal composite forage and preparation method thereof |
| CN105106387A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for preventing and treating white scour of piglets |
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Patent Citations (5)
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| CN102397372A (en) * | 2011-11-17 | 2012-04-04 | 云南云药科技股份有限公司 | Medicinal composition and pharmaceutical preparation and application thereof to treating irritable bowel syndrome |
| CN102743657A (en) * | 2012-07-31 | 2012-10-24 | 河南光泰动物药业有限公司 | Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof |
| CN102847017A (en) * | 2012-08-26 | 2013-01-02 | 裔群英 | Oral solution for prevention and treatment of piglet diarrhea, and preparation method thereof |
| CN105053633A (en) * | 2015-07-31 | 2015-11-18 | 无为县金宝生态农业开发有限公司 | Poultry physique improving Chinese herbal medicinal composite forage and preparation method thereof |
| CN105106387A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for preventing and treating white scour of piglets |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109793137A (en) * | 2017-11-16 | 2019-05-24 | 石继元 | A kind of food and preparation method thereof of white seven classes instant |
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