CN105796715B - A kind of Chinese herbal medicine formula and preparation method thereof for treating pig stomach enteritis disease - Google Patents
A kind of Chinese herbal medicine formula and preparation method thereof for treating pig stomach enteritis disease Download PDFInfo
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- CN105796715B CN105796715B CN201610334952.6A CN201610334952A CN105796715B CN 105796715 B CN105796715 B CN 105796715B CN 201610334952 A CN201610334952 A CN 201610334952A CN 105796715 B CN105796715 B CN 105796715B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to Chinese herbal medicine formulas and preparation method thereof, and in particular to a method of treat pig stomach enteritis disease.A kind of herbal composite for treating pig stomach enteritis disease, special proportion can treat pig stomach enteritis disease；It is crushed again for such proportion by breaking-wall cell grade, by the effective component of Chinese herbal medicine cell interior, as breaking-wall cell broken wall is adequately precipitated and mixes, reaching has and more than the curative effect of Chinese traditional herbs decocting decoction, and therapeutic effect is obvious；Intracellular effective component is filled dilution to come out, the dosage of Chinese herbal medicine will significantly reduce, and reduce the cost of Chinese herbal medicine, while effect is but high unlike drug effect when decreases.
Description
Technical field
The invention belongs to Chinese herbal medicine formulas and preparation method thereof, and in particular to a method of treat pig stomach enteritis disease.
Background technique
Antibiotic is always the main path for preventing and treating diarrhea of pigs, it can inhibit pathogen to a certain extent
Breeding, but also will affect the growth of normal flora in enteron aisle simultaneously, long-term unconfined use easily causes disease of digestive tract；By
In the use lack of standardization of antibiotic, the quantity of antibody-resistant bacterium is continuously increased, and drug resistance constantly enhances, more seriously livestock and poultry body
Interior medicament residue has seriously threatened the health of mankind itself.Currently, many countries have formulated relevant laws and regulations to limit
The antibiotic usage amount of livestock and poultry and being forbidden to use for part antibiotic, but do not have.
Summary of the invention
The technical problems to be solved by the present invention are: in view of the deficienciess of the prior art, providing a kind of using modern first
Into processing technique of Chinese herbs research and develop safe and efficient, easy treatment pig stomach enteritis disease in conjunction with the pathogenesis of live pig disease
Chinese herbal medicine formula and preparation method thereof.
In order to solve the above technical problems, being achieved using following technical scheme:
A kind of herbal composite for treating pig stomach enteritis disease, composition group become radix tetrastigme 16-24 parts, radix bupleuri 8-12
Part, 8-12 parts of asarum, 8-12 parts of taro Wu, 8-12 parts of the root of Dahurain angelica, 8-12 parts of rhizoma atractylodis, 16-24 parts of stop dysentery grass, 8-12 parts of Divine Comedy.
Preferably, this method includes the following steps:
1) it kibbles mill: the above herbal composite being ground into 48-52 mesh powder through common grinder roughing, and will
Powder is sufficiently mixed, it is therefore an objective to original block-like substance be become powdery, only in this way carrying out breaking-wall cell again could sufficiently analyse
Drug effect out cannot grind too thin by experiment discovery powder, if pulverizer can carefully remove active principle very much during grinding processed,
The powder of above-mentioned size is most accurate in the method；
2) breaking-wall cell: mixed semi-finished product are put into breaking-wall cell tank, are controlled vacuum state in tank and are dropped to 0.06-
Under 0.08 atmospheric pressure, making to vaporize fracturing cell walls in mixture, vacuum is kept for 4-5 minutes, and mixture is crushed in breaking-wall cell grade,
Crush the Ultramicro-powder for 280-320 mesh；Wherein radix tetrastigme etc. is bulk, as radix tetrastigme stem's fiber more than cannot to do cell broken
Wall.
Compared with prior art, the beneficial effects of the present invention are: special proportion can treat pig stomach enteritis disease；Needle again
Such proportion is crushed by breaking-wall cell grade, is filled by the effective component of Chinese herbal medicine cell interior, with breaking-wall cell broken wall
The precipitation and mixing divided, reaches the curative effect and be more than with Chinese traditional herbs decocting decoction, and therapeutic effect is obvious；Wherein mixture
The formulation and proportion of amount all consider fiber content, cannot have high microsteping in the composition of selection containing quantity of material, in order to avoid influence
The effect of breaking-wall cell；Intracellular effective component is filled dilution to come out, the dosage of Chinese herbal medicine will significantly reduce, and reduce medium-height grass
The cost of medicine, while effect is but high unlike drug effect when, decreases.
Specific embodiment
The following specific embodiments of the present invention is to make a detailed explanation.
Embodiment 1
A kind of herbal composite for treating pig stomach enteritis disease, composition group become radix tetrastigme 10g, radix bupleuri 5g, asarum 5g,
Taro Wu 5g, root of Dahurain angelica 5g, rhizoma atractylodis 5g, stop dysentery grass 10g, Divine Comedy 5g.
A kind of preparation method of herbal composite that treating pig stomach enteritis disease, this method include the following steps:
Composition in the above herbal composite is ground into 48 mesh powders through common grinder roughing, and by powder
It is sufficiently mixed, mixed semi-finished product is put into breaking-wall cell tank, control vacuum state in tank and drop under 0.06 atmospheric pressure, make
Fracturing cell walls are vaporized in mixture, vacuum is kept for 4 minutes, and mixture is crushed in breaking-wall cell grade, is crushed as the 50g of 280 mesh
Ultramicro-powder.The formulation and proportion wherein measured all consider fiber content, but the single high microsteping such as radix tetrastigme stem is containing quantity of material
It cannot be put into, so all there is no high microstepings to contain quantity of material in the composition of selection.
The application method of 50g Chinese herbal medicine are as follows:
The piglet every of weanling pig to 50 jin feeds 10 grams of Chinese herbal medicine daily, is used in conjunction 5 days, just 1 piglet uses.
It can be reserved for 12 months or more under shady and cool dry environment, preservation must be unable to knocking in air environment under encapsulation situations.
Embodiment 2
A kind of herbal composite for treating pig stomach enteritis disease, composition group become radix tetrastigme 14g, radix bupleuri 7g, asarum 8g,
Taro Wu 7g, root of Dahurain angelica 8g, rhizoma atractylodis 8g, stop dysentery grass 15g, Divine Comedy 7g.
A kind of preparation method of herbal composite that treating pig stomach enteritis disease, this method include the following steps:
Composition in the above herbal composite is ground into 50 mesh powders through common grinder roughing, and by powder
It is sufficiently mixed, mixed semi-finished product is put into breaking-wall cell tank, control vacuum state in tank and drop under 0.07 atmospheric pressure, make
Fracturing cell walls are vaporized in mixture, vacuum keeps 4 points of halfs, and mixture is crushed in breaking-wall cell grade, crushed as 300 purposes
75g Ultramicro-powder.The formulation and proportion wherein measured all consider fiber content, but the single high microsteping content object such as radix tetrastigme stem
Matter cannot be put into, so all there is no high microstepings to contain quantity of material in the composition of selection.
The application method of 75g Chinese herbal medicine are as follows: 50 jin to 100 jin of middle pig every feeds 15 grams of Chinese herbal medicine daily, is used in conjunction 5 days i.e.
Can, just 1 piglet uses.It can be reserved for 12 months or more under shady and cool dry environment, preservation must be under encapsulation situations, no
Energy knocking is in air environment.
Embodiment 3
A kind of herbal composite for treating pig stomach enteritis disease, composition group become 20 parts of radix tetrastigme, 10 parts of radix bupleuri, asarum
10 parts, 10 parts of taro Wu, 10 parts of the root of Dahurain angelica, 10 parts of rhizoma atractylodis, 20 parts, 10 parts of Divine Comedy of stop dysentery grass.
A kind of preparation method of herbal composite that treating pig stomach enteritis disease, this method include the following steps:
Composition in the above herbal composite is ground into 52 mesh powders through common grinder roughing, and by powder
It is sufficiently mixed, mixed semi-finished product is put into breaking-wall cell tank, control vacuum state in tank and drop under 0.08 atmospheric pressure, make
Fracturing cell walls are vaporized in mixture, vacuum is kept for 5 minutes, and mixture is crushed in breaking-wall cell grade, is crushed as 320 purposes
1000g Ultramicro-powder.The formulation and proportion wherein measured all consider fiber content, but the single high microsteping content such as radix tetrastigme stem
Substance cannot be put into, so all there is no high microstepings to contain quantity of material in the composition of selection.
The application method of 100g Chinese herbal medicine are as follows: big pig feeds 20 grams of Chinese herbal medicine for every daily, and 5 days, just 1 son are used in conjunction
Pig uses.It can be reserved for 12 months or more under shady and cool dry environment, preservation must be unable to knocking in air under encapsulation situations
In environment.
Experimental comparison
1, the experiment of Ultramicro-powder Chinese herbal medicine toxic side effect test
The three nest piglet 27 for selecting 28 ages in days, is grouped as unit of nest, establishes control group, test group 1, test group
2, by precuring in 2 days, start 7 days by a definite date addition Chinese herbal medicine spice feeding experiments.I.e. test group 1, test group 2 are added respectively
The Ultramicro-powder Chinese herbal medicine spice of Ultramicro-powder Chinese herbal medicine and doubling dose feeds 7d, and control group does not add Chinese herbal medicine, test group and right
It is even identical according to other feeding and management conditions of group.
It is as shown in the table to test concrete condition:
Experiment shows that the Chinese herbal medicine of this research and development does not have toxic side effect, does not generate adverse effect to pig growth and development.
2, the testing experiment of prevention (pig stomach enteritis disease) effect of Ultramicro-powder Chinese herbal medicine
Selection is susceptible to suffer from season early winter of pig stomach enteritis disease, selects piglet 36 of the pig farm 35 age in days health, establishes control
Group and test group 1, test group 2, i.e. control group (blank group) do not have to addition Chinese herbal medicine, and 1 group of test group and test group 2 are added respectively
The Ultramicro-powder Chinese herbal medicine of Ultramicro-powder Chinese herbal medicine and doubling dose；In order to ensure drug validity test, experiment divides 35 ages in days, 65 days again
Two stages of age add medication, and each stage addition administration time is 5 days, then observe pig growing state.
It is as shown in the table to test concrete condition:
Test group addition has used the live pig of Chinese herbal medicine to show active, hair color light, diarrhea situation does not occur, without
Using the control group of any prophylactic agent, then there is a pig a small amount of diarrhea situation occur.Experiments have shown that Chinese veterinary drug preparation is to prevention
The disease has certain effect.
3, the testing experiment for the treatment of (pig stomach enteritis disease) effect of Ultramicro-powder Chinese herbal medicine
Selection has suffered from the sick pig 12 (selection age in days is suitable, pig similar in weight) of pig stomach enteritis disease, is divided into two groups, one group
Using Western medicine, Western medicine is treated purchased from novel chiral synthon shop in Jinyun, medicine name mequindox injection+enrofloxacin injection,
For control group；One group is treated with Ultramicro-powder Chinese herbal medicine, is test group.The Contrast on effect of two groups of development treatment pig stomach enteritis diseases
Experiment.For sick pig during treatment, the feeding and management condition of every sick pig is identical, examines clinical change with taking a broad view of daily.
It is as shown in the table to test concrete condition:
With Chinese herbal treatment pig stomach enteritis disease and with western medicine pig stomach enteritis disease therapeutic effect all having the same.Experiment
It is also shown that with administration time to be extended with the time compared with Western medicine of Chinese herbal treatment, but Chinese herbal treatment is to the side such as appetite of pig
Stress reaction caused by face is smaller.
3 embodiments mainly use embodiment 2, this embodiment can apply to piggy and big pig, whole with frequently
Compared with balance, by experiment, Ultramicro-powder Chinese herbal medicine can be directly added into feed and feed live pig, the administrated method with traditional Chinese herbal medicine
It compares, there is advantage easy to use, efficient.
Claims (2)
1. a kind of herbal composite for treating pig stomach enteritis disease, which is characterized in that composition group becomes radix tetrastigme 16-24 parts,
8-12 parts of radix bupleuri, 8-12 parts of asarum, 8-12 parts of Wu taro, 8-12 parts of the root of Dahurain angelica, 8-12 parts of rhizoma atractylodis, 16-24 parts of stop dysentery grass, Divine Comedy 8-12
Part.
2. a kind of preparation method of herbal composite for treating pig stomach enteritis disease described in claim 1, it is characterised in that should
Method includes the following steps:
Composition in the above herbal composite is ground into 48-52 mesh powder through common grinder roughing, and by powder
It is sufficiently mixed, then mixed semi-finished product is ground into the Ultramicro-powder of 280-320 mesh with breaking-wall cell grade.
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| CN102743657A (en) * | 2012-07-31 | 2012-10-24 | 河南光泰动物药业有限公司 | Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof |
| CN102847017A (en) * | 2012-08-26 | 2013-01-02 | 裔群英 | Oral solution for prevention and treatment of piglet diarrhea, and preparation method thereof |
| CN105053633A (en) * | 2015-07-31 | 2015-11-18 | 无为县金宝生态农业开发有限公司 | Poultry physique improving Chinese herbal medicinal composite forage and preparation method thereof |
| CN105106387A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for preventing and treating white scour of piglets |
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2016
- 2016-05-19 CN CN201610334952.6A patent/CN105796715B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397372A (en) * | 2011-11-17 | 2012-04-04 | 云南云药科技股份有限公司 | Medicinal composition and pharmaceutical preparation and application thereof to treating irritable bowel syndrome |
| CN102743657A (en) * | 2012-07-31 | 2012-10-24 | 河南光泰动物药业有限公司 | Traditional Chinese medicine composition for preventing piglet dysentery and preparation method thereof |
| CN102847017A (en) * | 2012-08-26 | 2013-01-02 | 裔群英 | Oral solution for prevention and treatment of piglet diarrhea, and preparation method thereof |
| CN105053633A (en) * | 2015-07-31 | 2015-11-18 | 无为县金宝生态农业开发有限公司 | Poultry physique improving Chinese herbal medicinal composite forage and preparation method thereof |
| CN105106387A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for preventing and treating white scour of piglets |
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