CN108245630A - For preventing the Chinese medicine composition of pig breeding and respiratory syndrome, fermented type Chinese medicine microecological preparation and its preparation method and application - Google Patents

For preventing the Chinese medicine composition of pig breeding and respiratory syndrome, fermented type Chinese medicine microecological preparation and its preparation method and application Download PDF

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CN108245630A
CN108245630A CN201710939367.3A CN201710939367A CN108245630A CN 108245630 A CN108245630 A CN 108245630A CN 201710939367 A CN201710939367 A CN 201710939367A CN 108245630 A CN108245630 A CN 108245630A
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chinese medicine
respiratory syndrome
medicine composition
preparation
radix
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CN108245630B (en
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张永
康静静
张峰
冯白
胡清茹
史洪涛
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Animal Husbandry Henan One Animal Pharmaceutical Co Ltd
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Animal Husbandry Henan One Animal Pharmaceutical Co Ltd
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The present invention relates to a kind of for preventing the Chinese medicine composition of pig breeding and respiratory syndrome, fermented type Chinese medicine microecological preparation and its preparation method and application.The Chinese medicine composition of the present invention, is made of the component of following parts by weight：0.3~0.7 part of Radix Codonopsis, 0.8~1.2 part of Radix Astragali, 0.2~0.6 part of the fleece-flower root, 0.2~0.6 part of oldenlandia diffusa, 0.5~0.9 part of tripterygium wilfordii, 0.2~0.4 part of Glabrous Sarcandra Herb, 0.3~0.7 part of coix seed, 0.2~0.4 part of Rhizoma Et Radix Notopterygii, 0.2~0.4 part of Radix Angelicae Pubescentis, 0.1~0.3 part of gypsum, 0.2~0.4 part of radix bupleuri, 0.2~0.6 part of charred FRUCTUS CRATAEGI, 0.2~0.6 part of melanoidin malt, 0.2~0.6 part of stir-baked MASSA FERMENTATA MEDICI-NALIS.The Chinese medicine composition of the present invention has good effect in terms of prevention pig breeding is with respiratory tract collective species, can dramatically increase the feed intake of piglet after wean, reduce the death rate of piglet.

Description

For preventing pig breeding and Chinese medicine composition, the fermented type Chinese medicine of respiratory syndrome Probiotics and its preparation method and application
Technical field
The present invention relates to a kind of for preventing Chinese medicine composition, the micro- life of fermented type Chinese medicine of pig breeding and respiratory syndrome State preparation and its preparation method and application, belongs to veterinary drug technical field.
Background technology
Porcine reproductive and respiratory syndrome (PRRS) is one of swinery generation characterized by breeding difficulty and Respiratory symptoms Acute, hyperinfection the viral infectious of kind, pathogen are the member of Arterivirus, are a kind of sub-threads for having cyst membrane Positive chain RNA virus, virion be in ball-type, a diameter of 55~60 nanometers.Virus has 2 serotypes, i.e. american type and Europe class, The strain that isolated in China arrives is american type.It is presented with expiratory dyspnea symptom mostly after the pig morbidity at various ages, sow shows as Apocleisis, body temperature such as increase, are short of breath, having a running nose at flu-like symptoms, miscarriage, stillborn foetus, the mummification of fetus etc., after boar infection Performance cough, sneezing, dyskinesia, decreased libido, semen quality decline etc..Piglet show as apocleisis, it is drowsiness, cough, exhale Inhale difficult, asthma or ear cyanosis etc..PRRS often results in serious financial consequences.In recent years, which was presented apparent height at home Hair trend causes heavy losses to pig breeding industry, it has also become one of Important Infectious Diseases of serious threat China pig breeding industry development.
China's Chinese herbal medicine resource enriches, and certain Chinese medicines also have the spy for improving and adjusting fuselage state while antibacterial Property improves the effect of immunity of organisms.Lactic acid bacteria is a kind of microbe additive of work, and use is often added in feed to dynamic Object growth, body health play an important roll, and can improve intestinal environment and promote digestion, inhibit pathogen, play and build up health, control The pathogenetic effect of disease processed, is clinically verified.Chinese herbal medicine is after lactic acid bacteria solid fermentation, the extracted amount of active ingredient Increase, toxicity reduces and can generate new active material improves its treatment and preventive effect.
Invention content
The object of the present invention is to provide a kind of for preventing pig breeding and the Chinese medicine composition of respiratory syndrome, for pre- When the pig breeding of anti-weanling pig is with respiratory syndrome, the daily ingestion amount of piglet can be dramatically increased.
Meanwhile the present invention also provides a kind of for preventing pig breeding and the fermented type Traditional Chinese drug microecology of respiratory syndrome Preparation.
In addition, the present invention also provides a kind of above-mentioned micro- with the fermented type Chinese medicine of respiratory syndrome for preventing pig breeding The preparation method and application of ecological agent.
In order to achieve the goal above, the present invention's is adopted for preventing pig breeding and the Chinese medicine composition of respiratory syndrome Technical solution is：
It is a kind of to be used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, by the component group of following parts by weight Into：0.3~0.7 part of Radix Codonopsis, 0.8~1.2 part of Radix Astragali, 0.2~0.6 part of the fleece-flower root, 0.2~0.6 part of oldenlandia diffusa, tripterygium wilfordii 0.5~0.9 part, 0.2~0.4 part of Glabrous Sarcandra Herb, 0.3~0.7 part of coix seed, 0.2~0.4 part of Rhizoma Et Radix Notopterygii, 0.2~0.4 part of Radix Angelicae Pubescentis, 0.1~0.3 part of gypsum, 0.2~0.4 part of radix bupleuri, 0.2~0.6 part of charred FRUCTUS CRATAEGI, 0.2~0.6 part of melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS 0.2~ 0.6 part.
The present invention's breeds the characteristic of each traditional Chinese medicine ingredients in the Chinese medicine composition with respiratory syndrome such as preventing pig Under：
Radix Codonopsis：For common traditional tonic, the Radix Codonopsis that ancient times are produced using Shanxi Shangdang area has bowl spares benefit as top grade The effect of gas, strengthening spleen and tonifying lung.Modern study, Radix Codonopsis is containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, soap Glucoside and Alkaloid have the effects that strengthen immunity, expansion blood vessel, decompression, improve microcirculation, enhancing hematopoiesis function.This There is castering action to leucocyte decline caused by chemotherapy radiotherapy outside.
Radix Astragali：For leguminous herbaceous plant's astragalus mongolicus, the root of Astragalus membranacus, the Inner Mongol, Shanxi, Gansu, Heilungkiang are originated in Etc. ground, there is invigorating qi for strengthening superficies, profit water detumescence, pus draining and toxin expelling, myogenic and other effects.Radix Astragali is containing saponin, sucrose, polysaccharide, a variety of amino The various trace elements such as sour, folic acid and selenium, zinc, copper.Effect is invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.For gas Empty weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst are burst not long It holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes etc. can effectively be treated.
The fleece-flower root：Dried root for polygonum multiflorum thunb.Slightly warm in nature, it is bitter, sweet, enter liver, kidney.With heat-clearing solution Poison, dampness removing disappear carbuncle, the effect of anticancer.For scrofula sore carbuncle, rubella itch, dry constipation of intestines；Hyperlipidemia.
Oldenlandia diffusa：Herb for Rubiaceae plants of Hedyotis oldenlandia diffusa.It is its patent medicine bitter, light, it is cold in nature.Mainly Effect is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness, outstanding kind treatment various types inflammation.
Tripterygium wilfordii：For the root of Celastraceae plant tripterygium wilfordii, bitter, pungent, cool in nature, big poison.Return liver and kidney channel.Effect wind-dispelling removes It is wet, remove obstruction in channels to relieve pain, swelling and pain relieving, removing toxic substances desinsection.For damp and hot tubercle, carcinoma product poison.
Glabrous Sarcandra Herb：Drying complete stool for Chloranthaceae plant Chloranthus glaber.Slightly warm in nature, it is bitter, pungent.Clearing heat and cooling blood, promoting blood circulation disappear Spot, dispelling wind and removing obstruction in the meridians.For blood-head purple plague purpura, purpura, arthralgia pain due to rheumatism, traumatic injury.Major function antibacterial anti-inflammatory heat clearing and blood cooling detoxifies, Dispelling wind and removing obstruction in the meridians, blood circulation promoting and dispersing pathogen accumulation.
Coix seed：Dry mature kernal for grass Job's tears.It is cool in nature, it is sweet in flavor, light.Returns spleen, stomach, lung channel.Have Invigorating the spleen excreting dampness, clearing away heat and eliminating pus, eliminating impediment, the function of Li Shui.
Rhizoma Et Radix Notopterygii：Dissipate exterior cold；Wind-damp dispelling；Sharp joint；Analgesic.Master catches cold；It has a headache lossless；Mimeograph cold-dampness numbness；It floats in geomantic omen It is swollen；Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, waist and knee crymodynia, deficiency of the kidney and dyspnea, Diarrhoea；External application curing vitiligo, spot It is bald.Relieving exterior syndrome and dispelling cold, expelling wind and eliminating dampness, analgesic.
Radix Angelicae Pubescentis：Pungent, bitter, the taste temperature of property.Return liver, kidney, bladder warp.Expelling wind and eliminating dampness；Eliminating cold to stop pain.For wind-cold-dampness arthralgia；Waist and knee Pain；Few the moon volt wind headache, dentalgia of having a headache.
Gypsum：For monoclinic system mineral, main chemical compositions are the hydrate of calcium sulfate.It is pungent, sweet, Great Cold.Enter lung, stomach Through.For fever caused by exogenous pathogenic factors hyperpyrexia polydipsia lung heat cough and asthma, stomach fire a heatable brick bed is contained.Expelling pathogenic factors from muscles for clearing heat, relieving restlessness quenches the thirst, is clearing heat and detoxicating, purging intense heat.
Radix bupleuri：Bitter, cold nature.Return liver, gallbladder channel.Saturating table expels the heat-evil, and soothing liver-qi stagnation rises and lifts yang-energy.It cures mainly：Stagnation of QI due to depression of the liver, Sternal rib pain, rectal prolapse, uterus come off, irregular menstruation.
Charred FRUCTUS CRATAEGI is the product of hawthorn, acid, sweet, tepor.Return Pi, stomach, Liver Channel has food digesting stomach fortifying, promoting blood circulation and removing blood stasis, convergence The function of stop dysentery.
Melanoidin malt, barley get over year sward sheet, malt are taken to put in pot after micro- stir-fry to coke yellow, sprinkling clear water, taking-up is dried i.e. Into.Melanoidin malt is specially in promoting digestion, and for dyspepsia acid regurgitation, gastral cavity abdomen is bored swollen.
Stir-baked MASSA FERMENTATA MEDICI-NALIS, for what is formed after wholemeal and other drugs (sweet wormwood, Siberian cocklebur, polygonum flaccidum, almond, red bean) mixing through fermentation Processed goods.Warm-natured, returns spleen stomach has effects that promoting digestion and removing indigestion, strengthening the spleen and stomach.It is mainly used for retention of food and drink, indigestion, gastral cavity The diseases such as distention and fullness in the abdomen, loss of appetite, vomiting dysentery and married woman's postpartum congestion and abdominal pain, the big hard product of children's abdomen.
The present invention's is used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, Radix Codonopsis, Radix Astragali, fleece-flower root QI invigorating It enriches blood, tonifying spleen and stomach, protect liver kidney enhances immunity of organisms；Gypsum, radix bupleuri, oldenlandia diffusa, Glabrous Sarcandra Herb are clearing heat and detoxicating, purging intense heat, adjust Whole human body energy metabolism reduces the body temperature raising caused by fever, plays adjustment immunity of organisms, antivirus action；Rhizoma Et Radix Notopterygii, solely Living, tripterygium wilfordii dispelling wind and eliminating dampness, anti-inflammatory, analgesia are antiviral；Coix seed invigorating the spleen excreting dampness, clearing away heat and eliminating pus, eliminating impediment, Li Shui；Charred FRUCTUS CRATAEGI, Melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS promoting digestion and removing indigestion, strengthening the spleen and stomach.All medicine prescriptions use, rich in nutrition, clearing heat and detoxicating, dispelling wind and eliminating dampness, excreting dampness profit Water, stomach invigorating promote digestion and other effects, common to play the works such as enhancing immunity of organisms, antiviral, calm, anti-inflammatory, anti-oxidant, resisting stress With by adjustment various to body, achieving the purpose that treat disease.
Preferably, for preventing pig breeding and the Chinese medicine composition of respiratory syndrome, by the component of following parts by weight Composition：0.5 part of Radix Codonopsis, 1 part of Radix Astragali, 0.4 part of the fleece-flower root, 0.4 part of oldenlandia diffusa, 0.7 part of tripterygium wilfordii, 0.3 part of Glabrous Sarcandra Herb, the heart of a lotus seed 0.5 part of the seed of jog's tears, 0.3 part of Rhizoma Et Radix Notopterygii, 0.3 part of Radix Angelicae Pubescentis, 0.2 part of gypsum, 0.3 part of radix bupleuri, 0.4 part of charred FRUCTUS CRATAEGI, 0.4 part of melanoidin malt are burnt 0.4 part of Divine Comedy.
Skill used by the fermented type Chinese medicine microecological preparation for being used to prevent pig breeding and respiratory syndrome of the present invention Art scheme is：
It is a kind of to be used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, mainly with Chinese traditional medicine composition Object and fermenting microbe are prepared for raw material；The Chinese medicine composition is made of the component of following parts by weight：Radix Codonopsis 0.3~ 0.7 part, 0.8~1.2 part of Radix Astragali, 0.2~0.6 part of the fleece-flower root, 0.2~0.6 part of oldenlandia diffusa, 0.5~0.9 part of tripterygium wilfordii, 0.2~0.4 part of Glabrous Sarcandra Herb, 0.3~0.7 part of coix seed, 0.2~0.4 part of Rhizoma Et Radix Notopterygii, 0.2~0.4 part of Radix Angelicae Pubescentis, gypsum 0.1~0.3 Part, 0.2~0.4 part of radix bupleuri, 0.2~0.6 part of charred FRUCTUS CRATAEGI, 0.2~0.6 part of melanoidin malt, 0.2~0.6 part of stir-baked MASSA FERMENTATA MEDICI-NALIS.
The present invention for preventing pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, using Radix Codonopsis, The 14 taste Chinese medicine such as Radix Astragali is made with microorganism compounding fermentation, and traditional Chinese medicine ingredients pass through microorganism conversion, become small molecule by macromolecular, It is rapid-action, drug effect is high, is easily absorbed by organisms；The toxicant of Chinese herbal medicine can be decomposed in fermentation process simultaneously, drug is without residual It stays, has no toxic side effect, securely and reliably；Usage amount is small, at low cost.
Preferably, the Chinese medicine composition is made of the component of following parts by weight：0.5 part of Radix Codonopsis, 1 part of Radix Astragali, He Shou 0.4 part of crow, 0.4 part of oldenlandia diffusa, 0.7 part of tripterygium wilfordii, 0.3 part of Glabrous Sarcandra Herb, 0.5 part of coix seed, 0.3 part of Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis 0.3 Part, 0.2 part of gypsum, 0.3 part of radix bupleuri, 0.4 part of charred FRUCTUS CRATAEGI, 0.4 part of melanoidin malt, 0.4 part of stir-baked MASSA FERMENTATA MEDICI-NALIS.
The fermenting microbe is made of lactobacillus plantarum strain, streptococcusfaecium enterococci strain.Lactobacillus plantarum, middenstead coccus can It plays：Profitable strain is supplemented, maintains the effect of microecological balance；The digestant effect of nutrition；Improve the effect of immunity of organisms； It builds up health, control the pathogenetic effect of disease.
The lactobacillus plantarum strain is lactobacillus plantarum bacterium solution, and streptococcusfaecium enterococci strain is streptococcus fecalis bacterium solution.The plant Viable count is 2.0~4.0 × 10 in object lactobacillus strain8CFU/mL；Viable count is 4.0~6.0 in the streptococcusfaecium enterococci strain ×108 CFU/mL。
Preferably, the viable count in the lactobacillus plantarum strain is 3.0 × 108In CFU/mL, streptococcusfaecium enterococci strain Viable count is 5.0 × 108CFU/mL。
Preferably, the fermenting microbe is made of the component of volumes below number：30~70 parts of lactobacillus plantarum strain, excrement 80~120 parts of streptococcus strain.In the fermenting microbe that every 300~700g Radix Codonopsis uses the volume of lactobacillus plantarum for 30~ 70ml。
Preferably, it is described for preventing pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome mainly in Drug composition, fermenting microbe and fermenting additive are prepared for raw material.The fermenting additive by following parts by weight group It is grouped as：20~40 parts of peptone, 0.1~0.2 part of manganese sulfate, 20~40 parts of sodium acetate, 3~5 parts of potassium dihydrogen phosphate, calcium carbonate 10~20 parts.The mass ratio of peptone is 300~700 in the quality of Radix Codonopsis and fermenting additive in the Chinese medicine composition: 20~40.
Preferably, the fermenting additive is made of the component of following parts by weight：30 parts of peptone, manganese sulfate 0.15 Part, 30 parts of sodium acetate, 4.0 parts of potassium dihydrogen phosphate, 15 parts of calcium carbonate.
The present invention's is adopted for pig breeding and the preparation method of the fermented type Chinese medicine microecological preparation of respiratory syndrome Technical solution is：
It is a kind of above-mentioned for preventing pig breeding and the preparation method of the fermented type Chinese medicine microecological preparation of respiratory syndrome, Include the following steps：
1) Chinese medicine composition is taken to add water to cook, filter, fermenting additive is added in filtrate and is uniformly mixed, then adjusts pH It is 6~8, obtains culture solution；
2) after culture solution is sterilized, add in fermenting microbe 32~40 DEG C ferment 48~96h, obtain zymotic fluid to get.
In step 1), before decoction, first plus water is soaked for a period of time Chinese medicine composition, then decocted.The immersion Time is 4~6h.The fermenting additive is made of the component of following parts by weight：20~40 parts of peptone, manganese sulfate 0.1~ 0.2 part, 20~40 parts of sodium acetate, 3~5 parts of potassium dihydrogen phosphate, 10~20 parts of calcium carbonate.
In step 1), the decoction is divided into 3 times, is filtered after decocting every time, merging filtrate；Amount of water is decocted for the first time It it is 8~12 times of Chinese medicine composition weight, the time of decoction is 1.5~2h；It is Chinese medicine composition weight that second, which decocts amount of water, 4~6 times of amount, the time of decoction is 1~1.5h；Third time decocts 4~6 times that amount of water is Chinese medicine composition weight, decocts Time be 1~1.5h.Preferably, the fermenting additive is made of the component of following parts by weight：30 parts of peptone, sulfuric acid 0.15 part of manganese, 30 parts of sodium acetate, 4.0 parts of potassium dihydrogen phosphate, 15 parts of calcium carbonate.
In step 1), before adding in fermenting additive in filtrate, filtrate and Chinese medicine composition total weight are concentrated the filtrate to Than 1~3:1~2.
In step 2), the sterilizing is that culture solution is placed in closed container, 115~132 DEG C of high pressure sterilizations 15~ 45min。
It is above-mentioned to be used to prevent pig breeding and the preparation method of the fermented type Chinese medicine microecological preparation of respiratory syndrome, also Including the zymotic fluid obtained in step 2) concentration is made medicinal extract, and by extract dry, crush, obtain extract powder, then in medicinal extract Starch, dextrin and wetting agent are added in powder, is uniformly mixed, particle is made and is dried.
The temperature of the concentration is 50~70 DEG C.
The mass fraction of extract powder is 10~15% in dried particle.
The wetting agent is water.
The present invention's adds for preventing pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome as feed The used technical solution of application for adding agent is：
It is a kind of above-mentioned to add for preventing pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome as feed Add the application of agent.
For preventing pig breeding with the fermented type Chinese medicine microecological preparation of respiratory syndrome as feed addictive, it is used for When treating pig breeding with respiratory syndrome, the amount of fermented type Chinese medicine microecological preparation added in feed per ton is 4kg (with dry The quality meter of particle after dry)；During for preventing pig breeding with respiratory syndrome, the fermented type Chinese medicine that adds in feed per ton The amount of probiotics is 2kg (in terms of the quality of dried particle).Feed the fermented type Chinese medicine microecological preparation of the present invention When, it is used in conjunction every time 7~10 days, it is primary every 5~7 days repeated drug takings.
Specific embodiment
Technical scheme of the present invention is further described below in conjunction with specific embodiment.
Lactobacillus plantarum strain employed in specific embodiment is lactobacillus plantarum bacterium solution, and streptococcusfaecium enterococci strain is excrement Streptococcus bacterium solution.
Embodiment 1
The present embodiment is used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, by the component group of following weight Into：Radix Codonopsis 0.3kg, Radix Astragali 1.2kg, fleece-flower root 0.2kg, oldenlandia diffusa 0.6kg, tripterygium wilfordii 0.5kg, Glabrous Sarcandra Herb 0.4kg, the heart of a lotus seed Seed of jog's tears 0.3kg, Rhizoma Et Radix Notopterygii 0.4kg, Radix Angelicae Pubescentis 0.2kg, gypsum 0.3kg, radix bupleuri 0.2kg, charred FRUCTUS CRATAEGI 0.6kg, melanoidin malt 0.2kg are burnt Divine Comedy 0.6kg.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, mainly by this Chinese medicine composition, fermenting microbe and the fermenting additive of embodiment are prepared for raw material：The fermenting microbe is：Viable count is 2.0×108The lactobacillus plantarum strain 30mL and viable count of CFU/mL is 6.0 × 108The streptococcusfaecium enterococci strain of CFU/mL 120mL；Used fermenting additive is：Peptone 30g, manganese sulfate 0.2g, sodium acetate 20g, potassium dihydrogen phosphate 5.0g, carbonic acid Calcium 20g.
The present embodiment is used to prevent pig breeding and the preparation side of the fermented type Chinese medicine microecological preparation of respiratory syndrome Method includes the following steps：
1) water is added in Chinese medicine composition makes water not have Chinese medicine composition, and soaked overnight then proceedes to add water to water Gross mass is 10 times of Chinese traditional medicine composition amount of substance, then carries out first time decoction, and slightly boiling 2h is kept after boiling, and vacuum filtration obtains To a dregs of a decoction and first-time filtrate；
2) water that 4 times of Chinese traditional medicine composition amount of substance are added in a dregs of a decoction carries out second of decoction, keeps micro- after boiling 1h is boiled, vacuum filtration obtains the secondary dregs of a decoction and secondary filtrate；
3) water that 6 times of Chinese traditional medicine composition amount of substance are added in the secondary dregs of a decoction carries out third time decoction, keeps micro- after boiling 1h is boiled, vacuum filtration obtains the dregs of a decoction three times and three times filtrate；Merge 3 filtrates, be then concentrated into filtrate and Chinese medicine composition Mass ratio be 1:2, it is spare；
4) it adds in fermenting additive in filtrate after concentration to be uniformly mixed, it is 6 then to adjust pH, is packed into closed container and exists 115 DEG C of high pressure sterilization 45min, are cooled to room temperature, obtain culture solution；
5) fermenting microbe is added in culture solution, 96h is then left to ferment at 35 DEG C, obtained zymotic fluid is dense at 60 DEG C Contraction is into medicinal extract；It by obtained extract dry, crushes, obtains extract powder；Starch, dextrin and wetting agent is added in extract powder to mix It is even, be made particle, it is dry to get；Extract powder account for it is dry after particle gross mass 10%.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, for treating When pig is bred with respiratory syndrome, 4kg is added in feed per ton；It is per ton during for preventing pig breeding with respiratory syndrome 2kg is added in feed.It when feeding fermented type Chinese medicine microecological preparation, is used in conjunction every time 7~10 days, every 5~7 days repeated drug takings one It is secondary.
Embodiment 2
The present embodiment is used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, by the component group of following weight Into：Radix Codonopsis 0.3kg, Radix Astragali 1kg, fleece-flower root 0.6kg, oldenlandia diffusa 0.4kg, tripterygium wilfordii 0.5kg, Glabrous Sarcandra Herb 0.3kg, Job's tears Benevolence 0.7kg, Rhizoma Et Radix Notopterygii 0.3kg, Radix Angelicae Pubescentis 0.2kg, gypsum 0.2kg, radix bupleuri 0.4kg, charred FRUCTUS CRATAEGI 0.4kg, melanoidin malt 0.2kg, burnt god Bent 0.4kg.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, mainly by this The Chinese medicine composition of embodiment, fermenting microbe and fermenting additive are prepared；The fermenting microbe is：Viable count for 4.0 × 108The lactobacillus plantarum strain 50mL and viable count of CFU/mL is 5.0 × 108The streptococcusfaecium enterococci strain 100mL of CFU/mL；It is described Fermenting additive is：Peptone 20g, manganese sulfate 0.15g, sodium acetate 40g, potassium dihydrogen phosphate 3.0g, calcium carbonate 10g.
The present embodiment is used to prevent pig breeding and the preparation side of the fermented type Chinese medicine microecological preparation of respiratory syndrome Method includes the following steps：
1) water is added in Chinese medicine composition makes water not have Chinese medicine composition, and soaked overnight then proceedes to add water to water Gross mass is 8 times of Chinese traditional medicine composition amount of substance, then carries out first time decoction, and slightly boiling 1.5h is kept after boiling, and vacuum filtration obtains To a dregs of a decoction and first-time filtrate；
2) water that 6 times of Chinese traditional medicine composition amount of substance are added in a dregs of a decoction carries out second of decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the secondary dregs of a decoction and secondary filtrate；
3) water that 5 times of Chinese traditional medicine composition amount of substance are added in the secondary dregs of a decoction carries out third time decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the dregs of a decoction three times and three times filtrate；Merge 3 filtrates, be then concentrated into filtrate and Chinese traditional medicine composition The mass ratio of object is 3:1, it is spare；
4) it adds in fermenting additive in filtrate after concentration to be uniformly mixed, it is 8 then to adjust pH, is packed into closed container and exists 121 DEG C of high pressure sterilization 30min, are cooled to room temperature, obtain culture solution；
5) fermenting microbe is added in culture solution, 96h is then left to ferment at 32 DEG C, obtained zymotic fluid is dense at 60 DEG C Contraction is into medicinal extract；It by obtained extract dry, crushes, obtains extract powder；Starch, dextrin and wetting agent is added in extract powder to mix It is even, be made particle, it is dry to get；Extract powder account for it is dry after particle gross mass 11%.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, for treating When pig is bred with respiratory syndrome, 4kg is added in feed per ton；It is per ton during for preventing pig breeding with respiratory syndrome 2kg is added in feed.It when feeding fermented type Chinese medicine microecological preparation, is used in conjunction every time 7~10 days, every 5~7 days repeated drug takings one It is secondary.
Embodiment 3
The present embodiment is used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, by the component group of following weight Into：Radix Codonopsis 0.7kg, Radix Astragali 1kg, fleece-flower root 0.2kg, oldenlandia diffusa 0.4kg, tripterygium wilfordii 0.9kg, Glabrous Sarcandra Herb 0.3kg, Job's tears Benevolence 0.3kg, Rhizoma Et Radix Notopterygii 0.3kg, Radix Angelicae Pubescentis 0.4kg, gypsum 0.2kg, radix bupleuri 0.2kg, charred FRUCTUS CRATAEGI 0.4kg, melanoidin malt 0.6kg, burnt god Bent 0.2kg.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, mainly by this The Chinese medicine composition of embodiment, fermenting microbe and fermenting additive are prepared；Used fermenting microbe is：Viable count is 3.0×108The lactobacillus plantarum strain 70mL and viable count of CFU/mL is 4.0 × 108The streptococcusfaecium enterococci strain 80mL of CFU/mL； Used fermenting additive is：Peptone 40g, manganese sulfate 0.1g, sodium acetate 30g, potassium dihydrogen phosphate 5.0g, calcium carbonate 15g。
The present embodiment is used to prevent pig breeding and the preparation side of the fermented type Chinese medicine microecological preparation of respiratory syndrome Method includes the following steps：
1) water is added in Chinese medicine composition makes water not have Chinese medicine composition, and soaked overnight then proceedes to add water to water Gross mass is 12 times of Chinese traditional medicine composition amount of substance, then carries out first time decoction, and slightly boiling 2h is kept after boiling, and vacuum filtration obtains To a dregs of a decoction and first-time filtrate；
2) water that 4 times of Chinese traditional medicine composition amount of substance are added in a dregs of a decoction carries out second of decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the secondary dregs of a decoction and secondary filtrate；
3) water that 4 times of Chinese traditional medicine composition amount of substance are added in the secondary dregs of a decoction carries out third time decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the dregs of a decoction three times and three times filtrate；Merge 3 filtrates, be then concentrated into filtrate and Chinese medicine composition Mass ratio be 1:1, it is spare；
4) it adds in fermenting additive in filtrate after concentration to be uniformly mixed, it is 7 then to adjust pH, is packed into closed container and exists 132 DEG C of high pressure sterilization 15min, are cooled to room temperature, obtain culture solution；
5) fermenting microbe is added in culture solution, 48h is then left to ferment at 40 DEG C, obtained zymotic fluid is dense at 60 DEG C Contraction is into medicinal extract；It by obtained extract dry, crushes, obtains extract powder；Starch, dextrin and wetting agent is added in extract powder to mix It is even, be made particle, it is dry to get；Extract powder account for it is dry after particle gross mass 12%.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, for treating When pig is bred with respiratory syndrome, 4kg is added in feed per ton；It is per ton during for preventing pig breeding with respiratory syndrome 2kg is added in feed.It when feeding fermented type Chinese medicine microecological preparation, is used in conjunction every time 7~10 days, every 5~7 days repeated drug takings one It is secondary.
Embodiment 4
The present embodiment is used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, by the component group of following weight Into：Radix Codonopsis 0.5kg, Radix Astragali 1kg, fleece-flower root 0.4kg, oldenlandia diffusa 0.4kg, tripterygium wilfordii 0.7kg, Glabrous Sarcandra Herb 0.3kg, Job's tears Benevolence 0.5kg, Rhizoma Et Radix Notopterygii 0.3kg, Radix Angelicae Pubescentis 0.3kg, gypsum 0.2kg, radix bupleuri 0.3kg, charred FRUCTUS CRATAEGI 0.4kg, melanoidin malt 0.4kg, burnt god Bent 0.4kg.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, mainly by this The Chinese medicine composition of embodiment, fermenting microbe and fermenting additive are prepared；Used fermenting microbe is：Viable count is 3.0×108The lactobacillus plantarum strain 50mL and viable count of CFU/mL is 5.0 × 108The streptococcusfaecium enterococci strain of CFU/mL 100mL；Used fermenting additive is：Peptone 30g, manganese sulfate 0.15g, sodium acetate 30g, potassium dihydrogen phosphate 4.0g, carbon Sour calcium 15g.
The present embodiment is used to prevent pig breeding and the preparation side of the fermented type Chinese medicine microecological preparation of respiratory syndrome Method includes the following steps：
1) water is added in Chinese medicine composition makes water not have Chinese medicine composition, impregnates 4h, then proceedes to add water to the total of water Quality is 10 times of Chinese traditional medicine composition amount of substance, then carries out first time decoction, and slightly boiling 1.5h is kept after boiling, and vacuum filtration obtains To a dregs of a decoction and first-time filtrate；
2) water that 5 times of Chinese traditional medicine composition amount of substance are added in a dregs of a decoction carries out second of decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the secondary dregs of a decoction and secondary filtrate；
3) water that 5 times of Chinese traditional medicine composition amount of substance are added in the secondary dregs of a decoction carries out third time decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the dregs of a decoction three times and three times filtrate；Merge 3 filtrates, be then concentrated into filtrate and Chinese traditional medicine composition The mass ratio of object is 2:1, it is spare；
4) it adds in fermenting additive in filtrate after concentration to be uniformly mixed, it is 7 then to adjust pH, is packed into closed container and exists 121 DEG C of high pressure sterilization 30min, are cooled to room temperature, obtain culture solution；
5) fermenting microbe is added in culture solution, 72h is then left to ferment at 37 DEG C, obtained zymotic fluid is dense at 60 DEG C Contraction is into medicinal extract；It by obtained extract dry, crushes, obtains extract powder；Starch, dextrin and wetting agent is added in extract powder to mix It is even, be made particle, it is dry to get；Extract powder account for it is dry after particle gross mass 13%.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, for treating When pig is bred with respiratory syndrome, 4kg is added in feed per ton；It is per ton during for preventing pig breeding with respiratory syndrome 2kg is added in feed.It when feeding fermented type Chinese medicine microecological preparation, is used in conjunction every time 7~10 days, every 5~7 days repeated drug takings one It is secondary.
Embodiment 5
The present embodiment is used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, by the component group of following weight Into：Radix Codonopsis 0.7kg, Radix Astragali 0.8kg, fleece-flower root 0.6kg, oldenlandia diffusa 0.2kg, tripterygium wilfordii 0.9kg, Glabrous Sarcandra Herb 0.2kg, the heart of a lotus seed Seed of jog's tears 0.7kg, Rhizoma Et Radix Notopterygii 0.2kg, Radix Angelicae Pubescentis 0.4kg, gypsum 0.1kg, radix bupleuri 0.4kg, charred FRUCTUS CRATAEGI 0.2kg, melanoidin malt 0.6kg are burnt Divine Comedy 0.2kg.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, mainly by this The Chinese medicine composition of embodiment, fermenting microbe and fermenting additive are prepared；Used fermenting microbe is：Viable count is 4.0×108The lactobacillus plantarum strain 50mL and viable count of CFU/mL is 4.0 × 108The streptococcusfaecium enterococci strain of CFU/mL 120mL；Used fermenting additive is：Peptone 30g, manganese sulfate 0.1g, sodium acetate 40g, potassium dihydrogen phosphate 3.0g, carbonic acid Calcium 15g.
The present embodiment is used to prevent pig breeding and the preparation side of the fermented type Chinese medicine microecological preparation of respiratory syndrome Method includes the following steps：
1) water is added in Chinese medicine composition makes water not have Chinese medicine composition, impregnates 6h, then proceedes to add water to the total of water Quality is 10 times of Chinese traditional medicine composition amount of substance, then carries out first time decoction, and slightly boiling 2h is kept after boiling, and vacuum filtration obtains Dregs of a decoction and first-time filtrate；
2) water that 5 times of Chinese traditional medicine composition amount of substance are added in a dregs of a decoction carries out second of decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the secondary dregs of a decoction and secondary filtrate；
3) water that 6 times of Chinese traditional medicine composition amount of substance are added in the secondary dregs of a decoction carries out third time decoction, keeps micro- after boiling 1h is boiled, vacuum filtration obtains the dregs of a decoction three times and three times filtrate；Merge 3 filtrates, be then concentrated into filtrate and Chinese medicine composition Mass ratio be 3:2, it is spare；
4) it adds in fermenting additive in filtrate after concentration to be uniformly mixed, it is 7 then to adjust pH, is packed into closed container and exists 132 DEG C of high pressure sterilization 30min, are cooled to room temperature, obtain culture solution；
5) fermenting microbe is added in culture solution, 48h is then left to ferment at 37 DEG C, obtained zymotic fluid is dense at 60 DEG C Contraction is into medicinal extract；It by obtained extract dry, crushes, obtains extract powder；Starch, dextrin and wetting agent is added in extract powder to mix It is even, be made particle, it is dry to get；Extract powder account for it is dry after particle gross mass 15%.
The present embodiment is used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, for treating When pig is bred with respiratory syndrome, 4kg is added in feed per ton；It is per ton during for preventing pig breeding with respiratory syndrome 2kg is added in feed.It when feeding fermented type Chinese medicine microecological preparation, is used in conjunction every time 7~10 days, every 5~7 days repeated drug takings one It is secondary.
Reference examples
The Chinese medicine composition used in reference examples is the same as embodiment 4.
Reference examples are used to prevent pig breeding and the preparation method of the Chinese medicine preparation of respiratory syndrome, including following step Suddenly：
1) water is added in Chinese medicine composition makes water not have Chinese medicine composition, and soaked overnight then proceedes to add water to water Gross mass is 10 times of Chinese traditional medicine composition amount of substance, then carries out first time decoction, and slightly boiling 2h is kept after boiling, and vacuum filtration obtains To a dregs of a decoction and first-time filtrate；
2) water that 5 times of Chinese traditional medicine composition amount of substance are added in a dregs of a decoction carries out second of decoction, keeps micro- after boiling 1.5h is boiled, vacuum filtration obtains the secondary dregs of a decoction and secondary filtrate；
3) water that 5 times of Chinese traditional medicine composition amount of substance are added in the secondary dregs of a decoction carries out third time decoction, keeps micro- after boiling 1h is boiled, vacuum filtration obtains the dregs of a decoction three times and three times filtrate；Merge 3 filtrates, be then concentrated into filtrate and Chinese medicine composition Mass ratio be 2:1, it is spare；
4) it adds in fermenting additive in filtrate after concentration to be uniformly mixed, it is 7 then to adjust pH, is packed into closed container and exists 121 DEG C of high pressure sterilization 30min, are cooled to room temperature, obtain culture solution；
5) medicinal extract is made in 60 DEG C of concentrations in culture solution after cooling；It by obtained extract dry, crushes, obtains medicinal extract Powder；Starch, dextrin and wetting agent mixing are added in extract powder, is made particle, it is dry to get；Extract powder accounts for particle after drying The 15% of gross mass.
Reference examples are used to prevent pig breeding and the Chinese medicine preparation of respiratory syndrome, comprehensive with respiratory tract in treatment pig breeding During simulator sickness, feed additive amount per ton is 4kg；When preventing pig breeding with respiratory syndrome, feed additive amount per ton is 2kg. When feeding Chinese medicine preparation, it is used in conjunction every time 7~10 days, it is primary every 5~7 days repeated drug takings.
Experimental example 1
280 28 age in days weanling pigs is selected to be randomly divided into seven groups, experimental group 1~5 distinguishes feeding and contains Examples 1 to 5 For preventing pig breeding and the feed of the fermented type Chinese medicine microecological preparation of respiratory syndrome.Group 6 is control group, and feeding contains The prevention pig breeding of reference examples and the feed of the Chinese medicine preparation of respiratory syndrome.Group 7 is blank group, and feeding is free of any drug Feed.Normal feeding management, entire during the experiment is freely eaten, free water.Immunity inoculation is carried out by normal immunological program, Seven groups of feeding and management conditions are consistent.Experiment periods totally 28 days (28 days~56 days).
The suggested use and dosage of the fermented type Chinese medicine microecological preparation of Examples 1 to 5 and the Chinese medicine preparation of reference examples：Spice is raised Hello, feed additive amount per ton is 2kg.It is used in conjunction 7~10 days every time, it is primary every 5~7 days repeated drug takings.
Testing index：Feed intake, daily day increment, record piglet death condition.
Experimental result：Experimental result is as shown in table 1.
The preventive effect of weaned piglets is compared after 1 each group medication of table
(note：Death rate decreasing value is experimental group 1~5 and the control group absolute value of the difference with the blank group death rate respectively.)
The result shows that compared with blank group, after the feed of the feeding fermented type Chinese medicine microecological preparation containing the present invention, piglet Feed intake, daily gain increase apparent.Specifically compared with blank group, experimental group 1~5 and the average end of control group are respectively increased again 2.75kg, 2.59kg, 2.58kg, 3.89kg, 2.66kg, 1.42kg, average daily gain increase respectively 0.12kg, 0.14kg, 0.09kg, 0.19kg, 0.12kg, 0.11kg, the death rate reduces 10.0% respectively, 12.5%, 10%, 15%, 12.5%, 5.0%, illustrating the fermented type Chinese medicine preparation of the present invention has good preventive effect.
Experimental example 2
There is lassitude, apocleisis, body temperature and the symptoms such as increases, has a running nose, having loose bowels in one pig farm farrowing sow of Nanyang, individually The symptoms such as infected pigs' limb end and have sharp ears cyanosis.Above-mentioned morbidity farrowing sow is randomly divided into 7 groups, experimental group 1~5 is fed respectively The feed of the fermented type Chinese medicine microecological preparation containing Examples 1 to 5 is eaten, organizes the feed of Chinese medicine preparation of 6 feedings containing reference examples, group 7 be control group, and feeding adds the feed of commercially available medicine.
The suggested use and dosage of the fermented type Chinese medicine microecological preparation of Examples 1 to 5 and the Chinese medicine preparation of reference examples：Feeding per ton Material additive amount is 4kg, calculates total feed intake daily and concentrates dispensing successively, is used in conjunction 7~10 days, is used every repetition in 5~7 days every time Medicine is primary.
Efficacy assessment standard is as follows：
It cures：Sow feeding, body temperature, spirit are normal, and farrowing restores normal.
It improves：Body temperature is normal, and feed intake increases；Farrowing and mental status return to normal.
In vain：Improvement target person is not achieved.
The therapeutic effect of different pharmaceutical is as shown in table 2.
The effect of fermented type Chinese medicine preparation of 2 Examples 1 to 5 of table, the Chinese medicine preparation of reference examples and commercially available medicine Comparison
By the experimental result of table 2 it is found that the present invention's is used to prevent pig breeding and the fermented type Chinese medicine of respiratory syndrome There is pregnancy the symptoms and miscarriage, stillborn foetus etc. such as depressed apocleisis, spirit, fever, sneezing, limb end cyanosis in probiotics The treated effect of illness is much larger than marketed drugs, and average litter size is generally higher than control group.Specifically：It is real in terms of cure rate Apply example 1~5, reference examples are respectively increased 12.6%, 14.7%, 14.6%, 16.5%, 14.7%, 5.0% than control group；Effectively Examples 1 to 5 in terms of rate, reference examples are respectively increased 19.1% than control group, 21.4%, 19.5%, 23.9%, 21.8%, 8.5%；With 4 highest of embodiment in terms of average litter size, 5.2 are improved than control group average litter size.Illustrate the use of the present invention There is the effect of more preferable in preventing pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome.
Experimental example 3
Henan Province Xinxiang pig farm weaned piglet is front and rear to be occurred under drowsiness, cough, expiratory dyspnea, body temperature raising, feed intake Drop, indivedual pigs show as eyes swelling, occur conjunctivitis, arthritis, ear redden, skin spottiness.Sick pig is often because of secondary sense Contaminate pleurisy, streptococcosis, disease of breathing and it is lethal.It is bred and breathing trace integration using the embodiment of the present invention 2 for preventing pig The fermented type Chinese medicine microecological preparation spice feeding of sign, feed per ton add fermented type Chinese medicine microecological preparation 4kg, to appetite not Good or useless exhausted pig, which uses, gavages method, it is ensured that every pig can obtain drug therapy.Swinery spirit turns condition turn after being used in conjunction 7 days It is good, fever symptoms are substantially reduced, appetite makes moderate progress, clinical symptoms disappear substantially after 10 days.

Claims (10)

1. a kind of be used to prevent pig breeding and the Chinese medicine composition of respiratory syndrome, it is characterised in that：By following parts by weight Component composition：0.3~0.7 part of Radix Codonopsis, 0.8~1.2 part of Radix Astragali, 0.2~0.6 part of the fleece-flower root, oldenlandia diffusa 0.2~0.6 Part, 0.5~0.9 part of tripterygium wilfordii, 0.2~0.4 part of Glabrous Sarcandra Herb, 0.3~0.7 part of coix seed, 0.2~0.4 part of Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis 0.2 ~0.4 part, 0.1~0.3 part of gypsum, 0.2~0.4 part of radix bupleuri, 0.2~0.6 part of charred FRUCTUS CRATAEGI, 0.2~0.6 part of melanoidin malt, burnt god It is 0.2~0.6 part bent.
2. a kind of be used to prevent pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, it is characterised in that：Mainly It is prepared using Chinese medicine composition and fermenting microbe as raw material；The Chinese medicine composition is made of the component of following parts by weight： 0.3~0.7 part of Radix Codonopsis, 0.8~1.2 part of Radix Astragali, 0.2~0.6 part of the fleece-flower root, 0.2~0.6 part of oldenlandia diffusa, tripterygium wilfordii 0.5 ~0.9 part, 0.2~0.4 part of Glabrous Sarcandra Herb, 0.3~0.7 part of coix seed, 0.2~0.4 part of Rhizoma Et Radix Notopterygii, 0.2~0.4 part of Radix Angelicae Pubescentis, gypsum 0.1~0.3 part, 0.2~0.4 part of radix bupleuri, 0.2~0.6 part of charred FRUCTUS CRATAEGI, 0.2~0.6 part of melanoidin malt, 0.2~0.6 part of stir-baked MASSA FERMENTATA MEDICI-NALIS.
3. according to claim 2 be used to prevent pig breeding and the fermentation microecological preparation of respiratory syndrome, feature It is：The fermenting microbe is made of lactobacillus plantarum strain, streptococcusfaecium enterococci strain.
4. it is according to claim 3 for preventing pig breeding and the fermented type Chinese medicine microecological preparation of respiratory syndrome, It is characterized in that：Viable count is 2.0~4.0 × 10 in the lactobacillus plantarum strain8CFU/mL；In the streptococcusfaecium enterococci strain Viable count is 4.0~6.0 × 108CFU/mL。
5. a kind of fermented type Chinese medicine microecological preparation as claimed in claim 2 for being used to prevent pig breeding and respiratory syndrome Preparation method, it is characterised in that：Include the following steps：
1) Chinese medicine composition is taken to add water to cook, filter, fermenting additive is added in filtrate and is uniformly mixed, it is 6 then to adjust pH ~8, obtain culture solution；
2) after culture solution is sterilized, add in fermenting microbe 32~40 DEG C ferment 48~96h, obtain zymotic fluid to get.
6. according to claim 5 breed and the fermented type Chinese medicine microecological preparation of respiratory syndrome for preventing pig Preparation method, it is characterised in that：In step 1), the decoction is divided into 3 times, is filtered after decocting every time, merging filtrate；First Secondary decoct amount of water as Chinese medicine composition weight 8~12 times, the time of decoction is 1.5~2h；Decocting amount of water for the second time is 4~6 times of Chinese medicine composition weight, the time of decoction is 1~1.5h；Third time decocts amount of water as Chinese medicine composition weight 4~6 times, the time of decoction is 1~1.5h.
7. according to claim 5 or 6 be used to prevent pig breeding and the fermented type Traditional Chinese drug microecology system of respiratory syndrome The preparation method of agent, it is characterised in that：In step 1), in filtrate add in fermenting additive before, concentrate the filtrate to filtrate with Chinese medicine composition total weight is than 1~3:1~2.
8. according to claim 5 breed and the fermented type Chinese medicine microecological preparation of respiratory syndrome for preventing pig Preparation method, it is characterised in that：It further includes and the zymotic fluid obtained in step 2) concentration is made medicinal extract, and by extract dry, powder It is broken, extract powder is obtained, then starch, dextrin and wetting agent are added in extract powder, be uniformly mixed, particle is made.
9. according to claim 8 breed and the fermented type Chinese medicine microecological preparation of respiratory syndrome for preventing pig Preparation method, it is characterised in that：The temperature of the concentration is 50~70 DEG C.
10. a kind of fermented type Traditional Chinese drug microecology system as claimed in claim 2 for being used to prevent pig breeding and respiratory syndrome Application of the agent as feed addictive.
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