CN102028918B

CN102028918B - Application of Tibetan medicinal composition to preparation of medicament for treating cerebral circulation insufficiency

Info

Publication number: CN102028918B
Application number: CN2010105936861A
Authority: CN
Inventors: 王彦峰; 李恒方; 张国霞; 张樱山; 陈丽娟
Original assignee: Tibet Cheezheng Tibetan Medicine Co Ltd
Current assignee: Tibet Cheezheng Tibetan Medicine Co Ltd
Priority date: 2010-12-17
Filing date: 2010-12-17
Publication date: 2012-01-04
Anticipated expiration: 2030-12-17
Also published as: CN102028918A

Abstract

The invention discloses application of a Tibetan medicinal composition to the preparation of a medicament for treating cerebral circulation insufficiency. The Tibetan medicinal composition consists of the following raw material medicaments in part by weight: 5 to 15 parts of lamiophlomis, 2 to 10 parts of whin, 15 to 60 parts of turmeric, 7 to 20 parts of pepper, 5 to 15 parts of buffalo horn, 15 to 40 parts of myricariagermanica, 0.1 to 2.5 parts of safflower, 0.1 to 5 parts of borneol and 0.1 to 5 parts of camphor. Further research on the pharmacology of the conventional Tibetan medicinal composition indicates that the Tibetan medicinal composition has good curative effect on cerebral circulation insufficiency. Moreover, natural wild medicinal materials from the Tibet Plateau are adopted and no chemically-synthesized stabilizing agent is added, so that the Tibetan medicinal composition has no toxic or side effect on a human body, is safe and effective and is suitable for all kinds of people and for treating various types of cerebral circulation insufficiency.

Description

The application of a kind of Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine

Technical field

The present invention relates to field of medicaments, the application of specifically a kind of Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine.

Background technology

Cerebral blood supply insufficiency is meant that a certain partial blood supply of human brain is not enough and causes the obstacle of brain function.At present, the chronic insufficient cerebral blood supply sickness rate is very high, has 2/3 people to suffer from chronic insufficient cerebral blood supply according to statistics in the mid-aged population, belongs to the frequently-occurring disease of middle-aged and elderly people.The home and abroad physician finds also that through big quantity research the clinical manifestation of chronic insufficient cerebral blood supply was once arranged in the morbidity of " senile dementia " and " cerebral infarction " early stage for a long time.If can not in time treat, so just cause the generation of " senile dementia " and " cerebral infarction " probably to chronic insufficient cerebral blood supply.Therefore, chronic insufficient cerebral blood supply b referred to as " the stealthy killer " who threatens middle-aged and elderly people healthy.Moreover, because a part of youngster has bad life habits such as smoking, excessive drinking, high salt, high sugar, the possibility of suffering from cerebrovascular disease is also arranged below 35 years old among the young crowd so cause.

Brain is the vitals of human body, though the weight of brain approximately only accounts for 2% of body wt, oxygen consumption but accounts for 20% of whole body oxygen consumption, and visible, its oxygen consumption is relatively large.The required oxygen of brain is all by blood supply, so must there be enough blood supplies to brain could guarantee its normal activity.The standard of weighing the cerebrum blood supply is a cerebral blood flow, and in a single day cerebral blood flow reduces, and the oxygen supply energy supply of brain cell will reduce immediately; Cerebral tissue if ischemia 10 surplus second, will cause that the function of brain changes; If a certain part blood flow of brain is blocked within a short period of time fully, the local brain tissue necrosis can take place, Here it is cerebral infarction; If blood supply in brain is not to block fully but reduce at leisure, Here it is chronic insufficient cerebral blood supply.

In fact, with advancing age, the blood supply meeting of brain reduces gradually.According to statistics, the Childhood cerebral blood flow is approximately 100 milliliters, and the adult is 50 milliliters, and healthy old men also just has only 35 milliliters; The cerebral tissue of adding middle-aged and elderly people is relatively low to the toleration of ischemia, and cerebrovascular homeostasis also descends gradually, therefore as long as slight variation takes place in blood supply, will obviously influence cerebral blood flow, thereby cause the generation of chronic insufficient cerebral blood supply.

The clinical symptoms of cerebral blood supply insufficiency has: (1) nervus motorius functional failure, and common performance such as unexpected mouth are askew, head piece saliva; Parathria and pronounce indistinctly, dysphagia do not expressed one's ideas in aphasia or language; One side limb adynamia or movable ineffective; Hold thing and fall, walk unstable or fall suddenly, have in addition limb spasm occurs or beat; (2) sensory disturbance often shows as face fiber crops, numb tongue, lip fiber crops and the numb or foreign body sensation of side limbs; What have feels into blurring of vision, even appears suddenly momentary blind; Many people also have unexpected spinning sensation; The limbs spontaneous pain that has; What also have occurs tinnitus, auditory dysesthesia etc. suddenly; (3) spirit and consciousness is unusual, the people be in extremely the Somnolence but be not overtired due to, but the tendency sign of cerebral blood supply insufficiency; Also the somebody shows as insomnia, and changing appears in the personality that has, like dissociableness, being reticent or apathetic expression or multi-lingual irritability; That have even of short duration loss of consciousness or intellectual deterioration occur, normal judgment is lost in more serious meeting.

The main diseases of cerebral blood supply insufficiency is because of having: the narrow or vasospasm of (1) some arterial blood tube chamber, and the blood flow that passes through reduces, and causes the brain district that is supplied that blood supply insufficiency takes place; (2) hemodynamics obstacle, when the blood pressure reduction, cerebral tissue blood supply insufficiency when the heart stroke volume reduces; (3) blood viscosity that causes of some reason increases, and blood flow slowly or the change of blood constituent also can cause blood supply insufficiency; (4) microthrombusis, microthrombus are that the atherosis plate of arterial pulse comes off, and in blood flow, form microemboli, arrive small artery and artery-clogging with blood flow, the local blood supply insufficiency of brain then can occur.

Cerebral blood supply insufficiency is reversible in early days, and correct treatment tends to obtain good effect.If not in place to this sick understanding, can not in time treat, possibly cause senile dementia, the cerebral infarction serious consequence of waiting indefinitely.

At present, mainly adopt the method treatment cerebral blood supply insufficiency of doctor trained in Western medicine, the selection principle of medicine is: nonjoinder diabetes, hyperlipemia, controlling of blood pressure good patient simultaneously can be selected the medicine and the cerebral circulation improving agent of anti-platelet aggregation for use.Complication with diabetes and ARR patient can select antiplatelet, anticoagulant for use and improve the medicine of cerebral circulation.The complicated hypertension person can use the cerebral circulation metabolism of hypotensive effect to improve medicine, if use the antihypertensive drugs (like ACE inhibitor) that does not influence cerebral circulation, should merge and use the cerebral circulation improving agent.Concrete medicine has: enteric Aspirin, calcium ion antagonist, medicament for expanding vascellum, cerebral metabolism and cerebral protective agent etc.These medicines all have side effect, and have drug resistance, are inappropriate for life-time service.

The traditional Chinese medical science thinks that brain is the refreshing clever mansion of unit, relies the nourishing of qi-blood-body fluid.Nourish then refreshing clever change of abundance, the then refreshing machine in the weary source of nourishing is ineffective.Dizziness, headache, head are heavy if qi-blood-body fluid deficiency or visceral dysfunction can occur, bradyphrenia, tinnitus, auditory dysesthesia, drowsiness but insomnia-middle, be prone to wake up, and numb limbs and tense tendons is heavy unable.Unable like the deficiency of vital energy, clear YANG failing to ascend is so that QI collapse caused by exhaustion of QI of the spleen and kidney; Not enough like blood deficiency, be difficult to give, brain loses and nourishes; Blood being the material foundation of QI, qi being the governor of blood, like deficiency in both Qi and blood, YANG-orifices failing to be nourished; Like internal organs yang deficiency, biochemical unable, the weary function in source is not enough; Like the precise and tiny deficiency of YIN, be difficult to press down sun, to such an extent as to yang hyperactivity; Like hematogenous blockage, stop the retardance mechanism of qi in the blood stasis; Or expectorant stops internal organs or hinders in clear key or go up illiteracy dizzy all diseases all to occur, and disease having laid particular stress on, and double holding under the arm respectively arranged.

Cerebral blood supply insufficiency belongs to the traditional Chinese medical science " dizzy " category.Though clinical wind, fire, expectorant are arranged, empty its common ground then be that the blood network is obstructed, its treatment ought be with blood circulation promoting and blood stasis dispelling, and dredging the meridian is main.

So when cerebral blood supply insufficiency was treated, if can adopt the raw material of Chinese medicine medicine as treatment cerebral blood supply insufficiency medicine, the injury to human body will reduce much relatively so.

Radix Lamiophlomidis Rotatae is the dry herb of dicotyledon Labiatae Radix Lamiophlomidis Rotatae Lamiophlomis rotata (Benth.) Kudo., and excavate latter stage in autumn, cleans, and dries.Its property is sweet, bitter, flat.Often be born in high mountain rubble beach, flood land or the stone matter grassy marshland of height above sea level 3900-5100m, be distributed in highlandss such as Tibet, Qinghai, Sichuan, Gansu.Have promoting blood circulation and hemostasis, wind-expelling pain-stopping effect, cure mainly diseases such as traumatic injury, traumatic hemorrhage, rheumatic arthralgia, grasserie, fracture, lumbar strain.

Herba Oxytropis Kansuensis is the dry herb of leguminous plant Herba Oxytropis falcatae Oxytropis falcata Bunge and Herba Oxytropis chiliophyllae Oxytropis falcataBunge.Excavate herb at the beginning of autumn late summer, clean earth, Ex-all is assorted takes out, and dries.Herba Oxytropis Kansuensis is the common plant in HOh Xil.Gas is different, mildly bitter flavor.Have the heal effect of skin ulcer, hesitant pulse hemostasis, relieving constipation of heat-clearing and toxic substances removing, granulation promoting, cure mainly epidemic disease, toxonosis, grasserie, constipation, diseases such as anthrax.

Rhizoma Curcumae Longae is a zingiberaceous plant Rhizoma Curcumae Longae Curcuma Longa L. rhizome.Excavate when stem and leaf is withered winter, cleans, and boils or steam to passing through the heart, dries, and removes fibrous root.Main product Sichuan, Fujian, Guangdong, Jiangxi, its property is hot, bitter, warm, returns spleen, Liver Channel.Has the removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia.Cure mainly diseases such as the breast side of body twinges, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.

Pericarpium Zanthoxyli is the dry mature skin of rutaceae green pepper Zanthoxylum schinifolium Sieb.etZucc. or Pericarpium Zanthoxyli Zanthoxylumbungeanum Maxim..The mature fruit of gathering autumn is dried, and removes seed and impurity, and its property is hot, warm.Return spleen, stomach, kidney channel.Be born in the bushes of hillside or on the sunny side, the roadside.Main product Sichuan, Shaanxi, Hebei.Have warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching cures mainly that coldness and pain in the epigastrium, vomiting are had loose bowels, diseases such as abdominal pain due to worm stagnation, ascariasis, eczema pruritus.

Cornu Bubali is the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.After getting the angle, decocting in water is except that chamfering plug, drying.Its hardship is salty, cold, goes into the heart, liver, spleen, stomach four warps.Have heat clearing away, removing heat from blood, Detoxication.Cure mainly calentura headache, high fever coma, macule, tell diseases such as nosebleed, infantile convulsion, sore throat pharyngeal swelling.

Cacumen Myricariae Germanicae is plant Cacumen Myricariae Germanicae Myricaria germanica (L.) Desv. of Cacumen Tamaricis section and the dry twig that belongs to several plants together, is used as medicine with sprout.Gather spring and summer, and the clip twig dries.Its property is puckery, sweet, cold.Be distributed in Hubei the east of Sichuan, Zigui and Wushan, Sichuan, be born in low bank, the mountains and rivers and roadside.Have heat-clearing and toxic substances removing, disperse the effect of rash, cure mainly diseases such as measles without adequate eruption, laryngopharynx swelling and pain, nosotoxicosis, grasserie, heat in blood disease, pestilence epidemic disease, internal organs be scorchingly hot.

Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Summer flower is plucked when red by xanthochromia, dries in the shade or dries.Its property is hot, warm, GUIXIN, Liver Channel.Have promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing cures mainly diseases such as amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.

Borneolum Syntheticum is that the resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum extracts the crystallization that obtains, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.Its property is arduous, cool, GUIXIN, lung meridian.It can be used for being used for the excess syndrome of stroke coma, is used for conjunctival congestion and swelling pain, the sore throat aphtha, is used for skin infection and swells and ache, and does not hold back after bursting etc.

Camphora is a kind of cyclohexane extraction monoterpene derivative, from the ketone that bark and the wooden distillation of Lignum cinnamomi camphorae makes, and also can be synthetic from Oleum Terebinthinae.Hot, the heat, poisonous of its property.GUIXIN, spleen channel.Effect dehumidifying parasite killing, warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Cure mainly scabies pruritus, traumatic pain, toothache.

In the prior art, Chinese patent document CN1709445 discloses Tibetan medicine of a kind of treating acute and chronic bruise, rheumatism, rheumatoid disease and preparation method thereof, and its crude drug is made up of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, Cacumen Myricariae Germanicae.Another Chinese patent document CN101574505A discloses a kind of Tibetan medicine aerosol of treating acute and chronic bruise, rheumatism, rheumatoid disease; Its crude drug is on the basis of the crude drug of above-mentioned patent documentation CN1709445, to add Flos Carthami, Borneolum Syntheticum and Camphora, promptly is made up of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, Cacumen Myricariae Germanicae, Flos Carthami, Borneolum Syntheticum, Camphora.Above-mentioned two kinds of Tibetan medicine compositionss have the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Above-mentioned two kinds of Tibetan medicine compositionss only are used to treat acute and chronic bruise, rheumatism, rheumatoid disease at present; Do not find the application of this Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine, and treatment acute and chronic bruise, rheumatism, rheumatoid disease are different fully with the pharmacological action of treatment cerebral blood supply insufficiency.

Summary of the invention

The object of the present invention is to provide a kind of application of Tibetan medicine compositions known in the state of the art.

For realizing above-mentioned purpose, the present invention adopts following technical scheme:

The application of a kind of Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine, the crude drug of wherein said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part.

The crude drug of said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part.

The crude drug of said Tibetan medicine compositions consists of following weight portion: 10 parts of Radix Lamiophlomidis Rotataes, 5 parts of Herba Oxytropis Kansuensiss, 30 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 10 parts of Cornu Bubalis, 30 parts of Cacumen Myricariae Germanicaes.

The crude drug of said Tibetan medicine compositions consists of following weight portion: 12 parts of Radix Lamiophlomidis Rotataes, 4 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 10 parts in Pericarpium Zanthoxyli, 11 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes.

Said Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.

The application of a kind of Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine, the crude drug of wherein said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part.

The crude drug of said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part, Flos Carthami 0.5-2 part, Borneolum Syntheticum 0.2-4 part, Camphora 0.2-4 part.

The crude drug of said Tibetan medicine compositions consists of following weight portion: 9.1 parts of Radix Lamiophlomidis Rotataes, 4.5 parts of Herba Oxytropis Kansuensiss, 40.9 parts in Rhizoma Curcumae Longae, 13.6 parts in Pericarpium Zanthoxyli, 9.1 parts of Cornu Bubalis, 22.7 parts of Cacumen Myricariae Germanicaes, 1.8 parts on Flos Carthami, 2 parts of Borneolum Syntheticums, 2 parts of Camphoras.

The crude drug of said Tibetan medicine compositions consists of following weight portion: 7 parts of Radix Lamiophlomidis Rotataes, 6 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 8 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes, 1 part on Flos Carthami, 0.5 part of Borneolum Syntheticum, 0.5 part of Camphora.

Tibetan medicine compositions described in the present invention has the effect of blood circulation promoting and blood stasis dispelling.This Tibetan medicine prescription is that the doctor among the people of Tibetan is carried, and combined the practical experience prescription to form according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " two secretaries.The natural quality authentic medicinal herbs is produced in raw materials used medicine polyphyly Qinghai-Tibet Platean, concocts according to the Tibetan medicine theory provision.Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae are the monarch drug of blood circulation promoting and blood stasis dispelling in the side, have the effect of blood circulation promoting and blood stasis dispelling, pain relieving; Pericarpium Zanthoxyli, Cornu Bubali have meridians dredging, the effect of wind-damp dispelling, yellow fluid reducing, and the monarch and his subjects' compatibility has strengthened curative effect.Because Cacumen Myricariae Germanicae is the good medicine of wind-damp dispelling, yellow fluid reducing, clearing away heat from blood, Flos Carthami promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain, Borneolum Syntheticum, Camphora have one's ideas straightened out refreshment, clearing away heat to alleviate pain, all medicine compatibilities more can strengthen it to all sick curative effects of cerebral blood supply insufficiency.

Technique scheme of the present invention is compared prior art and is had the following advantages:

The present invention can regulate total balance of the body effectively through the pharmacology of the disclosed Tibetan medicine compositions of patent documentation CN1709445 in the prior art further having been discovered this Tibetan medicine compositions; Thereby the allomeric function of enhances human body effectively; Blood circulation promoting and blood stasis dispelling; Guarantee the smooth and easy circulation of blood, make the brain oxygen-supplying amount sufficient, realized treatment effectively cerebral blood supply insufficiency.Simultaneously, in research further, find after further adding Flos Carthami, Borneolum Syntheticum and Camphora on the basis of above-mentioned Tibetan medicine composition component, equally cerebral blood supply insufficiency to be had the well treated effect.In addition, adopt the Qinghai-Tibet Platean to produce the natural crude drugs of pure natural in these two kinds of Tibetan medicine compositionss, do not add the stabilizing agent of any chemosynthesis, human body is not had toxic and side effects, safety, effective is applicable to all kinds of crowds, is suitable for treating various cerebral blood supply insufficiencys.

The specific embodiment

Embodiment 1

The preparation of powder

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 5 weight portions, Herba Oxytropis Kansuensis 2 weight portions, Rhizoma Curcumae Longae 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Cornu Bubali 5 weight portions, Cacumen Myricariae Germanicae 15 weight portions;

Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, the selection of Cacumen Myricariae Germanicae medical material of above-mentioned specified weight part is subsequent use, the above-mentioned raw materials medicine is processed the superfine powder of 1-10 μ m through superfine communication technique, process powder.

Embodiment 2

The preparation of capsule

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 8 weight portions, Herba Oxytropis Kansuensis 3 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 20 weight portions, Flos Carthami 0.5 weight portion, Borneolum Syntheticum 0.2 weight portion, Camphora 0.2 weight portion;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami of all the other specified weight parts are mixed; After it is pulverized; Water with 10 times of medical material weight decocts it, decocts to extract each 1 hour 3 times; Collect afterwards and merge above-mentioned three extracting solution, it is that 1.25 extractum is subsequent use that extracting solution is condensed into relative density; In the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again; Reduce to room temperature after stirring and this mixture is put into the aluminum dish; And said aluminum dish put into the vacuum freezing storehouse, the temperature in said vacuum freezing storehouse is reduced to-25 ℃, be provided with its internal vacuum for (＜10Pa); Taking-up opened a position after 16 hours; Mixture to after freezing is pulverized, and the Camphora, Borneolum Syntheticum and an amount of starch, sodium carboxymethyl cellulose, the carboxymethyl starch sodium that add above-mentioned specified weight part granulate, and fills, packing promptly gets capsule.

Embodiment 3

The preparation of granule

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is:

Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions, Flos Carthami 1.8 weight portions, Borneolum Syntheticum 2.0 weight portions, Camphora 2.0 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use, to all the other specified weight parts through remove impurity, clean, dried Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mixes and be ground into coarse powder, with 75% ethanol of 8 times of above-mentioned mixed medicinal materials weight above-mentioned mixed medicinal materials is extracted 3 times; Each 1.5h; Collect afterwards and merge above-mentioned three extracting solution, it is 1.20 extractum that extracting solution is condensed into relative density, in the extractum that obtains, adds above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again; Reduce to room temperature after stirring and this mixture is put into the aluminum dish; And said aluminum dish put into the vacuum freezing storehouse, the temperature in said vacuum freezing storehouse is reduced to-40 ℃, be provided with its internal vacuum for (＜10Pa); Taking-up opened a position after 12 hours; Mixture to after freezing is pulverized, and Borneolum Syntheticum and the Camphora that adds above-mentioned specified weight part mixes and add an amount of starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium granulates, and processes granule.

Embodiment 4

The preparation of tablet

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 15 weight portions, Herba Oxytropis Kansuensis 10 weight portions, Rhizoma Curcumae Longae 60 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 15 weight portions, Cacumen Myricariae Germanicae 40 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material are mixed, after it is pulverized, it is decocted with the water of 20 times of medical material weight; Decoct and extract 2 times; The each extraction 2 hours collected and merge extractive liquid, afterwards, and it is 1.15 extractum that extracting solution is condensed into relative density; The water that reuse extractum volume is 7 times dilutes it, crosses to filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 10 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol to there not being the alcohol flavor, concentrate spray drying; Obtain extract dry powder, and this extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder mix homogeneously again; Process the superfine powder of 0.1-1 μ m through superfine communication technique; In above-mentioned superfine powder, add starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium granulation, add the Pulvis Talci mix homogeneously again, tabletting, packing promptly get tablet.

Embodiment 5

The preparation of pill

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 15 weight portions, Herba Oxytropis Kansuensis 10 weight portions, Rhizoma Curcumae Longae 60 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 15 weight portions, Cacumen Myricariae Germanicae 40 weight portions, Flos Carthami 2.5 weight portions, Borneolum Syntheticum 5 weight portions, Camphora 5 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami to all the other specified weight parts mix and pulverizing; 50% ethanol with 15 times of above-mentioned mixed medicinal materials weight extracts 2 times above-mentioned mixed medicinal materials; Each 2h that extracts collects afterwards and merges above-mentioned extracted twice liquid, and it is 1.25 extractum that extracting solution is condensed into relative density; The water that reuse extractum volume is 5 times dilutes it, crosses to filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 30% washing with alcohol, resolve with 60% ethanol at last; Desorbed solution is reclaimed ethanol to there not being the alcohol flavor, concentrate lyophilization; Obtain extract dry powder, and this extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again; Mix homogeneously; Process the superfine powder of 1-10 μ m through superfine communication technique, the Borneolum Syntheticum, the Camphora that in above-mentioned superfine powder, add above-mentioned specified weight part mix, and add the debita spissitudo hydromel and process pill.

Embodiment 6

The preparation of soft capsule

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 10 weight portions, Herba Oxytropis Kansuensis 5 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 15 weight portions, Cornu Bubali 10 weight portions, Cacumen Myricariae Germanicae 30 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix also to be pulverized, with vinegar (total acid >=3.5g/100ml acetic acid) immersion of 6 times of medical material weight 7 days, medical material is fully expanded after; Place percolator; Percolate is slowly flowed out, collect percolate, reclaiming solvent, to get relative density be 1.15 extractum; In above-mentioned extractum, add Pericarpium Zanthoxyli, the Cornu Bubali fine powder of above-mentioned specified weight part again, stir the back and process soft capsule to wherein adding certain proportion gelatin, glycerol, water etc.

Embodiment 7

The preparation of spray

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 13 weight portions, Herba Oxytropis Kansuensis 8 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 13 weight portions, Cacumen Myricariae Germanicae 35 weight portions, Flos Carthami 2.0 weight portions, Borneolum Syntheticum 4.0 weight portions, Camphora 4.0 weight portions;

Adjuvant is: polyvidone 6 weight portions, glycerol 2 weight portions, tween 80 9 weight portions, tetrafluoroethane 30 weight portions;

It is for use that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m superfine powder; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and it are pulverized; 70% ethanol with 10 times of above-mentioned mixed medicinal materials weight extracts 3 times mixed medicinal materials; The each extraction 0.5 hour; Collect afterwards and merge above-mentioned three extracting solution, it is that 1.15 extractum is subsequent use that extracting solution is condensed into relative density; Again that Borneolum Syntheticum, Camphora, glycerol, Tween 80, the polyvidone of above-mentioned specified weight part is subsequent use with 60% dissolve with ethanol.Above-mentioned solution and extractum and the Pericarpium Zanthoxyli after micronizing, Cornu Bubali are merged, add ethanol and make and contain the alcohol amount in the mixed liquor and be 40%-50%, make 1000ml altogether, mixing, static, filter the back filling and sealing and get final product.

Embodiment 8

The preparation of ointment

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 12 weight portions, Herba Oxytropis Kansuensis 4 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 11 weight portions, Cacumen Myricariae Germanicae 25 weight portions;

It is for use that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m superfine powder; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix and it are pulverized, and with 75% ethanol of 8 times of above-mentioned mixed medicinal materials weight mixed medicinal materials are extracted 3 times, at every turn 1h; Collect afterwards and merge above-mentioned three extracting solution, it is 1.15 extractum that extracting solution is condensed into relative density, adds above-mentioned Pericarpium Zanthoxyli, Cornu Bubali superfine powder again; Reduce to room temperature and this mixture is put into the aluminum dish after stirring, and said aluminum dish is put into the vacuum freezing storehouse, the temperature in said vacuum freezing storehouse is reduced to-40 ℃; Be provided with its internal vacuum for (＜10Pa); The taking-up that opens a position after 24 hours is pulverized the mixture after freezing, and to wherein adding an amount of glycerol; Polyoxyethylene sorbitan monoleate mixes, and is heated to 80 degrees centigrade as water; With liquid paraffin, span mix homogeneously, be heated to 80 degrees centigrade as oil phase; Then that oil phase is mixed with water, below the restir to 37 degree centigrade, go out cream, fill, packing promptly gets.

Embodiment 9

The preparation of gel

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 7 weight portions, Herba Oxytropis Kansuensis 6 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 15 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 25 weight portions, Flos Carthami 1 weight portion, Borneolum Syntheticum 0.5 weight portion, Camphora 0.5 weight portion;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of specified weight part is broken into 0.01-200 μ m was for use, and the Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix also to be pulverized, with vinegar (total acid >=3.5g/100ml acetic acid) immersion of 10 times of above-mentioned mixed medicinal materials weight 2 days; After medical material is fully expanded, place percolator, percolate is slowly flowed out; Collect percolate, reclaiming solvent, to get relative density be 1.30 extractum, and Pericarpium Zanthoxyli, Cornu Bubali fine powder and the Camphora, the Borneolum Syntheticum that in above-mentioned extractum, add above-mentioned specified weight part again mix; Add an amount of carbomer again; Glycerol, propylene glycol, triethanolamine and suitable quantity of water; Mixing and stirring, filling and package promptly gets.

Embodiment 10

The preparation of rubber-emplastrum

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 8 weight portions, Herba Oxytropis Kansuensis 3 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 20 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of specified weight part is broken into 0.01-50 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix also to be pulverized, and it is decocted and extracts 3 times with the water of 10 times of above-mentioned mixed medicinal materials weight, and 1.5h at every turn collects afterwards and merges above-mentioned three extracting solution; It is 1.25 extractum that extracting solution is condensed into relative concentration, adds above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder, reduces to room temperature after stirring and this mixture is put into the aluminum dish, and said aluminum dish is put into the vacuum freezing storehouse; The temperature in said vacuum freezing storehouse is reduced temperature to-30 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 24 hours; Mixture to after freezing is pulverized, and to wherein adding natural rubber, zinc oxide; Lanoline, liquid paraffin is processed rubber-emplastrum, coating; Cut, packing, packing promptly gets.

Embodiment 11

The preparation of cataplasma

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 5 weight portions, Herba Oxytropis Kansuensis 2 weight portions, Rhizoma Curcumae Longae 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Cornu Bubali 5 weight portions, Cacumen Myricariae Germanicae 15 weight portions, Flos Carthami 0.1 weight portion, Borneolum Syntheticum 0.1 weight portion, Camphora 0.1 weight portion;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and pulverize; Water with 8 times of above-mentioned mixed medicinal materials weight decocts and extracts it 2 time; Each 1h that extracts; Reclaiming solvent, to get relative density be 1.20 extractum, and the water that reuse extractum volume is 8 times dilutes it, crosses to filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate, vacuum drying (0.08MPa); After the gained extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, mix homogeneously; Process the superfine powder of 0.01-50 μ m through superfine communication technique, Borneolum Syntheticum, Camphora and sodium polyacrylate 3 weight portions, gelatin 1 weight portion, glycerol 14 weight portions, propylene glycol 7 weight portions, dihydroxyaluminum aminoacetate 0.2 weight portion, methyl hydroxybenzoate 0.2 weight portion, butoben 0.2 weight portion and 50 weight parts waters that in above-mentioned superfine powder, add above-mentioned specified weight part mix, and stir; Coating; The lid lining cuts, and packing promptly gets cataplasma.

Embodiment 12

The preparation of slow releasing preparation

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 13 weight portions, Herba Oxytropis Kansuensis 8 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 13 weight portions, Cacumen Myricariae Germanicae 35 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix and pulverize; 75% ethanol with 8 times of amounts of medical material weight extracts 2 times above-mentioned mixed medicinal materials; Each 1h that extracts; Reclaiming solvent, to get relative density be 1.20 extractum, and the water dilution of 8 times of amounts of reuse extractum volume is crossed and filtered the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, vacuum drying, the gained extract dry powder is ground into fine powder after, add Pericarpium Zanthoxyli for use, Cornu Bubali fine powder again; Mix homogeneously is processed the superfine powder of 0.01-0.1 μ m through superfine communication technique, adds hydroxypropyl emthylcellulose and lactose in mortar, with its mixing; Add 80% alcoholic solution system soft material, cross 18 mesh sieves and granulate, wet granular is 50-60 ℃ of drying, and dried granule is through 16 mesh sieve granulate; Weighing adds magnesium stearate, mixing, and tabletting, encapsulation promptly gets.

Embodiment 13

The preparation of powder nose inhalant

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 12 weight portions, Herba Oxytropis Kansuensis 4 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 11 weight portions, Cacumen Myricariae Germanicae 25 weight portions, Flos Carthami 2.5 weight portions, Borneolum Syntheticum 1.0 weight portions, Camphora 1.0 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami of all the other specified weight parts are mixed; Pulverize,, extract 1h at every turn with 75% ethanol extraction of 8 times of above-mentioned mixed medicinal materials weight 2 times; Collect afterwards and merge above-mentioned extracted twice liquid; It is 1.20 extractum that extracting solution is condensed into relative density, the water dilution of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate vacuum drying; Obtain extract dry powder, and this extract dry powder is ground into fine powder, add Borneolum Syntheticum, the Camphora of above-mentioned specified weight part; Add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder mix homogeneously again; Add an amount of insoluble support MCC and bioadhesive polymers H-HPC, adopt grinding and freeze drying process to prepare powder spray, encapsulation promptly gets.

Embodiment 14

The preparation of slow-release paster

Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-50 μ m is for use, to all the other specified weight parts through remove impurity, clean, dried Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and be ground into coarse powder, with 70% ethanol of 10 times of above-mentioned mixed medicinal materials weight above-mentioned mixed medicinal materials is extracted 3 times; Each 1.5h; Collect afterwards and merge above-mentioned three extracting solution, it is 1.15 extractum that extracting solution is condensed into relative density, in the extractum that obtains, adds above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again; Reduce to room temperature after stirring and this mixture is put into the aluminum dish; And said aluminum dish put into the vacuum freezing storehouse, the temperature in said vacuum freezing storehouse is reduced to-30 ℃, be provided with its internal vacuum for (＜10Pa); Taking-up opened a position after 16 hours; Mixture to after freezing is pulverized, and adds the dense thick liquid of gelatin (get gelatin and add an amount of distilled water heated and stirred to even dense thick liquid), polyvinylpyrrolidone, Mentholum and stirs, and processes slow-release paster.

Embodiment 15

The preparation of tincture

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions;

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix and pulverize; 75% ethanol with 8 times of amounts of medical material weight extracts 2 times above-mentioned mixed medicinal materials; Each 1h that extracts; Reclaiming solvent, to get relative density be 1.20 extractum, and the water dilution of 8 times of amounts of reuse extractum volume is crossed and filtered the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrates, vacuum drying, the gained extract dry powder is ground into fine powder after, add Pericarpium Zanthoxyli for use, Cornu Bubali fine powder again, mix homogeneously is processed the superfine powder of 0.01-0.1 μ m through superfine communication technique, encapsulation gets final product.

Embodiment 16

The preparation of emplastrum

The crude drug that can be used for treating the Tibetan medicine compositions of cerebral blood supply insufficiency according to the invention is: Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions, Flos Carthami 1.5 weight portions, Borneolum Syntheticum 2.5 weight portions, Camphora 2.5 weight portions.

The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 50 μ m is for use; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and pulverize; Water with 10 times of above-mentioned mixed medicinal materials weight decocts and extracts it 3 time; Each 1.5h; Collect afterwards and merge above-mentioned three extracting solution, it is 1.20 extractum that extracting solution is condensed into relative concentration; The dilution of the water of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 5 times of bed volumes/hour macroporous adsorptive resins, use water washing earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate vacuum drying; After the gained extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, stir; The condition vacuum drying of 70 ℃ of temperature, vacuum 0.075MPa 24 hours, be ground into 120 purpose fine powders after taking out then.In above-mentioned fine powder, pack into behind the Borneolum Syntheticum of the above-mentioned specified weight part of adding, the Camphora mix homogeneously in the non-woven bag, seal, stick at and process emplastrum on the adhesive plaster, packing promptly gets.

As the distortion of the foregoing description, said Tibetan medicine compositions can be the arbitrary dosage form in pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, sublimed preparation, injection, cream, spray, drop pill, unguentum, ointment, cataplasma, gel, liniment, resin subsides, patch, slow releasing preparation, controlled release preparation or the freeze-dried powder preparation.

Experimental example

In order to show that above-mentioned two kinds of Tibetan medicine compositionss have the obvious treatment effect when being used for preparation treatment cerebral blood supply insufficiency medicine, the present invention has carried out record to the clinical use of said medicine:

Experimental example 1

Treat the clinical experiment of chronic back circulation (vertebral-basilar artery) blood supply insufficiency

1, case is selected

1.1 diagnostic criteria

Adopt calendar year 2001 shellfish political affairs chief editor " internal disease diagnostic criteria "

(1) headache, dizzy, subjective symptomss such as head is heavy, limb fiber crops; (2) finding of supporting cerebral arteriosclerosis is arranged:, pour into the vascular murmur of tremulous pulse sometimes with hypertension, ocular fundus arteriosclerosis change etc.; (3) do not see the focal neurosigns of brain; (4) CT/MRI scanning does not see that the organic brain of blood vessel changes; (5) get rid of the above-mentioned subjective symptoms that other diseases causes; (6) age is more than 45 years old; (7) cerebral circulation confirms that cerebral blood flow is low; (8) digital subtraction angiography (DSA) or TCD (TCD) prompting brain perfusion tremulous pulse has inaccessible or narrow change.

Meet the cerebral blood supply insufficiency diagnostic criteria: all possess to begin a project and can be diagnosed as cerebral blood supply insufficiency, wherein 1～5 is essential condition.

1.2 the diagnostic criteria of chronic back circulation (vertebral-basilar artery) blood supply insufficiency

(1) meets above-mentioned cerebral blood supply insufficiency diagnostic criteria.(2) mainly show as dizziness, giddy, can be slightly dizzy when heavy; Or being headache, tinnitus, blurred vision or grow dim, limbs are weak, unstable sense is arranged during walking, the sense of tilting, wave sense, astasia sense or top-heavy sense; Paraesthesias (nucleus sensorius nervi trigemini ischemia) such as face or mouthful week etc., above-mentioned symptom often is undulatory property, the time heavy when light; Position when change or travel time be than the dizzy weight of adding of long time, alleviates during clinostatism or disappear.(3) have or sign is slightly located by the impassivity system, active like tendon reflex, bilateral Roseau Li Mozheng (Rossolimo) positive is closed order astasia sense etc.(4) nuclear magnetic resonance (MRI) has or does not have brain stem chamber stalk, slight cerebellar atrophy, the slight expansion of four ventricles of the brain etc.(5) magnetic resonance angiography (MRA) or atraumatic blood vessel imaging technology (CTA) has certain diagnostic value to the blood supply of vertebral artery deficiency: do not develop like 1. vertebral artery; 2. luminal stenosis; 3. the both sides vertebral artery is asymmetric, it is generally acknowledged that a side diameter is promptly meaningful more than 1/3 less than opposite side, belongs to normally but grow obvious asymmetric person individually; 4. the vertebral artery vascular bending of cervical part of esophagus such as helical form etc.

1.3 the standard of including in

1.3.1 meet the diagnostic criteria of chronic back circulation (vertebral-basilar artery) blood supply insufficiency;

1.3.2TCD diagnosis: cerebral artery blood flow velocity is lower than lower limits of normal, blackout or adverse current;

1.3.3 the age is in 40-80 year;

1.3.4 voluntary accepting treatment, observation and inspection and signature informed consent person.

1.4, exclusion standard

1.4.1 transient ischemic attack (TIA) is toppled over the stage of attack patient;

1.4.2 the age is less than 40 years old or greater than 80 years old;

1.4.3 merge the brain solid lesion;

1.4.4 the cerebral blood supply insufficiency that following disease causes: facial disease, Meniere, labyrinthitis; Interior drug intoxication of ear, vestibular neuronitis auditory vertigo, cervical spondylosis; Intracranial mass lesion property disease, intracranial infection and intracranial demyelinating disease, anemia; Febris acuta property disease, the dizziness that causes behind paroxysmal tachycardia and atrioventricular block and the injury of head;

Use forbidden drugs and method 1.4.5 go into the group back: cerebral metabolism, blood circulation promoting and blood stasis dispelling dredging the meridian class Chinese medicine (except that the application test medicine), acupuncture and moxibustion therapy and body massaging etc.;

1.4.6 serious body complication is arranged, the heart, liver, kidney, pulmonary dysfunction person;

1.4.7 it is long-term or widely apply tranquilizer, expand blood vessel medicine and NSAID and in a short time can't the person of stopping using;

1.4.8 bleeding tendency person is arranged;

1.4.9 do not make medicament by prescriptive procedure, the shadow therapeutic evaluation.

1.5 therapeutic evaluation

1.5.1 detect entocranial artery VPV, direction, frequency spectrum and audio frequency through TCD,

1.5.2 overall state of an illness numeral staging (NRS): 0～10 digitized representation pain in various degree, 0 is asymptomatic, and 10 for being in a bad way, and 1～3 is slight, and 4～6 is moderate, 7～10 is severe;

1.5.3 dizzy, neck and shoulder pain, headache, daily life and work, psychology and social adjustment's scoring method for according to its symptom of saying by keep the score respectively (cervical vertigo patient symptom and functional assessment table are seen attached list) such as significance degree, persistent period, weight, frequency, self impressions.

1.6 the patient divides into groups and respectively organizes medication

1.6.1 divide into groups: the patient with in August, the 2006～2010 chronic back circulation of 280 examples (vertebral-basilar artery) blood supply insufficiencies that I institute accept for medical treatment, make a definite diagnosis in year January is divided into the 1-14 group, 45～75 years old age, 2～JIUYUE of the course of disease at random.The above-mentioned 1-14 group age and the preceding course of disease of going to a doctor are checked P＜0.01 through t.

1.6.2 it is following respectively to organize Therapeutic Method:

In above-mentioned 14 groups, the 1-13 group is the treatment group of the Tibetan medicine compositions among the present invention, and the 14th group is matched group.

The 1st group: with the granule (every bag 6 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 3 methods, each oral 1 bag, every day 1-2 time.

The 2nd group: with the soft capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 6 methods, each oral 4, every day 1-2 time.

The 3rd group: with the pill (every ball 0.2 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 5 methods, each oral 8 balls, every day 1-2 time.

The 4th group: with the powder (every bag 5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 1 method, each oral 2.5g, every day 1-2 time.

The 5th group: with the cataplasma (every subsides 10 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 11 methods, spread on painful area, paste every day 1.

The 6th group: with the rubber-emplastrum (every subsides 5 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 10 methods, spread on painful area, paste every day 1.

The 7th group: with the slow releasing preparation (every slice 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 12 methods, each oral 3, every day 1 time.

The 8th group: with the tablet (every slice 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 4 methods, each oral 3, every day 1-2 time.

The 9th group:, be applied in painful area, every day 1-2 time with the ointment (every 20 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 8 methods.

The 10th group:, be sprayed on painful area, every day 3-5 time with the spray (every bottle 50 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 7 methods.

The 11st group:, be applied in painful area, every day 1-2 time with the gel (every bottle 5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 9 methods.

The 12nd group: with the slow-release paster (every subsides 5mg gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 14 methods, spread on painful area, 1-2 pastes weekly.

The 13rd group: with the capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 2 methods, each oral 4, every day 1-2 time.

The 14th group (matched group), the oral ZHENNAONING JIAONANG of by specification (Tonghua Dongbao Pharmaceutical Co., Ltd's production).

1.7 curative effect determinate standard

Computing formula (nimodipine method) is: [integration before (integration before treatment back integration-treatment) ÷ treatment] * 100%

2, statistical method

EPIdata software is adopted in data management; Statistical analysis adopts the SPSS12.0 statistical software to carry out analyzing and processing.Constituent ratio is with the t check between two groups, two groups of means relatively with the t check, curative effect is with the comparison of Ridit value between two groups.The P value is less than or equal to 0.05 difference that will be considered to checked has statistical significance.

3, experimental result

1-13 group (treatment group) is all carried out Drug therapy with the 14th group (matched group), through t check, P＜0.01.Tibetan medicine compositions 1-13 group total effective rate of the present invention is respectively 80.00%, 78.94%, 82.61%, 72.22%, 76.47%, 75.00%, 80.95%, 77.78%, 78.95%, 81.82%, 80.95%, 85.00%, 75.00%; The ZHENNAONING JIAONANG effective percentage is 50.00%; Through statistical analysis P＜0.01 statistical significance is arranged; The treatment group all is superior to matched group, and t checks P＜0.01, influences such as no liver, renal function.The result sees table 1:

The chronic back circulation of table 1 treatment (vertebral-basilar artery) blood supply insufficiency result

Tibetan medicine compositions 1-13 group curative effect of the present invention obviously is superior to matched group (P＜0.01).

4, untoward reaction

The treatment group is during treating, and obvious adverse reaction does not all take place all experimenters.

Through above the clinical research result of Tibetan medicine compositions among the present invention to the treatment of chronic back circulation (vertebral-basilar artery) blood supply insufficiency shown; Said Tibetan medicine compositions 1-13 group total effective rate is respectively 80.00%, 78.94%, 82.61%, 72.22%, 76.47%, 75.00%, 80.95%, 77.78%, 78.95%, 81.82%, 80.95%, 85.00%, 75.00%; Curative effect is superior to ZHENNAONING JIAONANG matched group effective percentage 50.00%; Through statistical analysis P＜0.01 statistical significance is arranged; Therefore the treatment group all is superior to matched group, and the Tibetan medicine compositions among the present invention has excellent curative to chronic back circulation (vertebral-basilar artery) blood supply insufficiency.

Experimental example 2

Treat the clinical experiment of chronic preceding circulation (internal carotid artery) blood supply insufficiency

1, case is selected

1.1 diagnostic criteria

1.2 the diagnostic criteria of circulation (internal carotid artery) blood supply insufficiency before chronic

(1) meets above-mentioned cerebral blood supply insufficiency diagnostic criteria.(2) mainly showing as preceding disordered brain function, is main with mental symptom promptly: hypomnesis, particularly recent amnesia, title are forgotten etc.; Bradykinesia, apathetic expression, absent minded, emotional instability (anxiety, irritability), insomnia, ability to work descends, and judgment descends; Pass in time; Even personality changes, bigoted can appear, and so that slight dementia etc. takes place, can there be inclined to one side side limbs to send out deadlock, aching and tired, paraesthesia etc.(3) do not have definite neural location sign, can have that sucking reflex is positive, palm jaw reflex positive, Rossolimo (+), tendon reflex are enlivened etc.(4) iconography has (asymptomatic) or does not have chamber stalk, slight brain atrophy and white matter demyelination in various degree.(5) MRA or CTA carotid artery system have or do not have narrow or inaccessible.

1.3 the standard of including in

1.3.1 meet the diagnostic criteria of chronic preceding circulation (internal carotid artery) blood supply insufficiency type;

1.3.3 the age is in 40-80 year;

1.4, exclusion standard

1.4.1 acute TIA topples over the stage of attack patient;

1.4.2 the age is less than 40 years old or greater than 80 years old;

1.4.3 merge the brain solid lesion;

1.4.8 bleeding tendency person is arranged;

1.5 therapeutic evaluation

1.6 the patient divides into groups and respectively organizes medication

1.6.1 divide into groups: with in August, 2006～2,010 280 examples that I institute accept for medical treatment, make a definite diagnosis year January chronic before the patient of circulation (internal carotid artery) blood supply insufficiencies, be divided into the 1-14 group at random, 45～75 years old age, 2～JIUYUE of the course of disease.The above-mentioned 1-14 group age and the preceding course of disease of going to a doctor are checked P＜0.01 through t.

1.6.2 it is following respectively to organize Therapeutic Method

The 6th group: with the capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 2 methods, each oral 4, every day 1-2 time.

The 12nd group: with the emplastrum (every subsides 5 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 16 methods, spread on painful area, paste every day 1.

The 13rd group: with the rubber-emplastrum (every subsides 5 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 10 methods, spread on painful area, paste every day 1.

1.7 curative effect determinate standard

2, statistical method

3, experimental result

1-13 group (treatment group) is all carried out Drug therapy with the 14th group (matched group), through t check, P＜0.01.Tibetan medicine compositions 1-7 group total effective rate of the present invention is respectively 81.82%, 76.47%, 80.00%, 78.95%, 86.36%, 73.68%, 80.95%, 77.27%, 77.78%, 85.00%, 76.19%, 78.95%, 80.00%; The ZHENNAONING JIAONANG effective percentage is 45.00%; Through statistical analysis P＜0.01 statistical significance is arranged; The treatment group all is superior to matched group, and t checks P＜0.01, influences such as no liver, renal function.The result sees table 2:

Circulation (internal carotid artery) blood supply insufficiency result before table 2 treatment is chronic

4, untoward reaction

Through above the clinical research result of Tibetan medicine compositions among the present invention to circulation (internal carotid artery) blood supply insufficiency treatment before chronic shown; Said Tibetan medicine compositions effective percentage is respectively 81.82%, 76.47%, 80.00%, 78.95%, 86.36%, 73.68%, 80.95%, 77.27%, 77.78%, 85.00%, 76.19%, 78.95%, 80.00%; The curative effect Yiganning capsule matched group 45.00% that is superior to easing pain; Through statistical analysis P＜0.01 statistical significance is arranged, the treatment group all is superior to matched group.Therefore, the Tibetan medicine compositions among the present invention has excellent curative to circulation (internal carotid artery) blood supply insufficiency before chronic.

Experimental example 3

Treat the clinical experiment of chronic full cerebral blood supply insufficiency

1, case is selected

1.1 diagnostic criteria

1.2 the diagnostic criteria of chronic full cerebral blood supply insufficiency

1.3 the standard of including in

1.3.1 meet chronic full cerebral blood supply insufficiency diagnostic criteria;

1.3.3 the age is in 40-80 year;

1.4, exclusion standard

1.4.1 acute TIA topples over the stage of attack patient;

1.4.2 the age is less than 40 years old or greater than 80 years old;

1.4.3 merge the brain solid lesion;

1.4.8 bleeding tendency person is arranged;

1.5 therapeutic evaluation

1.51 detect entocranial artery VPV, direction, frequency spectrum and audio frequency through TCD,

1.6 the patient divides into groups and respectively organizes medication

1.6.1 divide into groups: the patient with in August, the 2006～2010 chronic full cerebral blood supply insufficiencys of 280 examples that I institute accept for medical treatment, make a definite diagnosis in year January is divided into the 1-14 group, 45～75 years old age, 2～JIUYUE of the course of disease at random.The above-mentioned 1-14 group age and the preceding course of disease of going to a doctor are checked P＜0.01 through t.

1.6.2 it is following respectively to organize Therapeutic Method

The 12nd group:, dip in to take a morsel with absorbent cotton and be applied to the affected part, every day 1-2 time with the tincture of the Tibetan medicine compositions among the present invention according to embodiment 15 methods preparations.

1.7 curative effect determinate standard

2, statistical method

3, experimental result

1-13 group (treatment group) is all carried out Drug therapy with the 14th group (matched group), through t check, P＜0.01.Tibetan medicine compositions 1-13 group total effective rate of the present invention is respectively 72.22%, 80.00%, 81.82%, 73.68%, 76.19%, 77.78%, 80.95%, 80.00%, 75.00%, 80.95%, 82.35%, 81.82%, 75.00%; Analgesia Yiganning capsule effective percentage is 57.14%; Through statistical analysis P＜0.01 statistical significance is arranged; The treatment group all is superior to matched group, and t checks P＜0.01, influences such as no liver, renal function.The result sees table 3.

The full cerebral blood supply insufficiency result of table 3 treatment

4, untoward reaction

Through above the clinical research result of Tibetan medicine compositions among the present invention to full cerebral blood supply insufficiency treatment shown; Said Tibetan medicine compositions effective percentage is respectively 72.22%, 80.00%, 81.82%, 73.68%, 76.19%, 77.78%, 80.95%, 80.00%, 75.00%, 80.95%, 82.35%, 81.82%, 75.00%; The curative effect Yiganning capsule matched group 57.14% that is superior to easing pain; Through statistical analysis P＜0.01 statistical significance is arranged, the treatment group all is superior to matched group.Therefore, the Tibetan medicine compositions among the present invention has excellent curative to full cerebral blood supply insufficiency.

Subordinate list:

Cervical vertigo patient symptom and functional assessment table

1, dizzy (16 minutes) (full marks totally 30 minutes)

The A degree

8 minutes: asymptomatic

6 minutes: slightly dizzy, can stand, can normally walk

4 minutes: moderate was dizzy, felt bad, and still can walk

2 minutes: severe was dizzy, and the utmost point is felt bad, and walking is had any problem, and needed to help or sit down

0 minute: acutely dizzy, almost can't stand, need bed

The B frequency

4 minutes: asymptomatic

3 minutes: every month about 1 time

2 minutes: about weekly 1 time

1 minute: about 1 time of every day

0 minute: every day for several times

The C persistent period

4 minutes: asymptomatic

3 minutes: several seconds～a few minutes

2 minutes: a few minutes～1 hour

1 minute: several hours

0 minute: one day or more than

2, neck and shoulder pain (4 minutes)

4 minutes: asymptomatic

3 minutes: slight, can stand

2 minutes: moderate, feel bad

1 minute: severe, the utmost point was felt bad

0 minute: violent, almost can't stand

3, headache (2 minutes)

2 minutes: asymptomatic

1.5 divide: slight, can stand

1 minute: moderate, feel bad

0.5 divide: severe, the utmost point is felt bad

0 minute: violent, almost can't stand

4, daily life and work (4 minutes)

Daily life need help situation (2 minutes) between the A period of disease

2 minutes: do not need

1.5 divide: need once in a while

1 minute: often need

0.5 divide: need in a large number, leaving helps to take care of oneself has any problem

0 minute: rely on fully, leave help and can't take care of oneself

Working condition between the B period of disease (2 minutes)

2 minutes: just the same with originally

1.5 divide: need suitably alleviate, can go up full class

1 minute: need obviously alleviate, still can go up full class

0.5 divide: need alleviate in a large number, can only first class

0 minute: the work of can't going to work

5, psychology and social adjustment (4 minutes)

?	No	Seldom	Once in a while	Often have	Have always
						Feel depressed, depressed	4	3	2	1	0
Passionnate than usual, angry, irritated	4	3	2	1	0
						The state of an illness to oneself is worried about	4	3	2	1	0
It is poor than usual to sleep	4	3	2	1	0
						Difficulty as usual with Get Along with People	4	3	2	1	0

Obviously, the foregoing description only be for explanation clearly done for example, and be not qualification to embodiment.For the those of ordinary skill in affiliated field, on the basis of above-mentioned explanation, can also make other multi-form variation or change.Here need not also can't give exhaustive to all embodiments.And conspicuous variation of being extended out thus or change still are among the protection domain of the invention.

Claims

1. the application of Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine, the crude drug of wherein said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part.

2. application according to claim 1 is characterized in that, the crude drug of said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part.

3. application according to claim 1 is characterized in that, the crude drug of said Tibetan medicine compositions consists of following weight portion: 10 parts of Radix Lamiophlomidis Rotataes, 5 parts of Herba Oxytropis Kansuensiss, 30 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 10 parts of Cornu Bubalis, 30 parts of Cacumen Myricariae Germanicaes.

4. application according to claim 1 is characterized in that, the crude drug of said Tibetan medicine compositions consists of following weight portion: 12 parts of Radix Lamiophlomidis Rotataes, 4 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 10 parts in Pericarpium Zanthoxyli, 11 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes.

5. application according to claim 1; It is characterized in that said Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, powder, unguentum, sublimed preparation, injection, cream, spray, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.

6. the application of Tibetan medicine compositions in preparation treatment cerebral blood supply insufficiency medicine, the crude drug of wherein said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part.

7. application according to claim 6; It is characterized in that the crude drug of said Tibetan medicine compositions consists of following weight portion: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part, Flos Carthami 0.5-2 part, Borneolum Syntheticum 0.2-4 part, Camphora 0.2-4 part.

8. application according to claim 6; It is characterized in that the crude drug of said Tibetan medicine compositions consists of following weight portion: 9.1 parts of Radix Lamiophlomidis Rotataes, 4.5 parts of Herba Oxytropis Kansuensiss, 40.9 parts in Rhizoma Curcumae Longae, 13.6 parts in Pericarpium Zanthoxyli, 9.1 parts of Cornu Bubalis, 22.7 parts of Cacumen Myricariae Germanicaes, 1.8 parts on Flos Carthami, 2 parts of Borneolum Syntheticums, 2 parts of Camphoras.

9. application according to claim 6; It is characterized in that the crude drug of said Tibetan medicine compositions consists of following weight portion: 7 parts of Radix Lamiophlomidis Rotataes, 6 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 8 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes, 1 part on Flos Carthami, 0.5 part of Borneolum Syntheticum, 0.5 part of Camphora.

10. application according to claim 6; It is characterized in that said Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, powder, unguentum, sublimed preparation, injection, cream, spray, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.