CN103933374A - Formula of traditional Chinese medicine for treating migraine and preparation method thereof - Google Patents

Abstract

The invention relates to a formula of a traditional Chinese medicine for treating migraine and a preparation method thereof. The traditional Chinese medicine is mainly prepared from the following raw materials in part by weight: 10-16 parts of radix angelicae, 4-8 parts of gastrodia elata, 12-20 parts of clematis filamentosa dunn, 2-7 parts of scorpio, 6-12 parts of fructus viticis, 3-9 parts of stiff silkworms, 8-12 parts of ching-chieh, 8-14 parts of ligusticum wallichii and 4-13 parts of rhizome of fourleaf paris. The traditional Chinese medicine provided by the invention has the characteristics of exact curative effect, fast effect, high cure rate and no toxic and side effects and has the purpose of treating both symptoms and root causes for migraine and symptoms thereof.

Description

Treat migrainous Chinese medicinal formulae and preparation method thereof

Technical field

The present invention relates to one and treated migrainous Chinese medicinal formulae and preparation method thereof, belonged to Chinese medicine field, be mainly used in treating migraine.

Background technology

The periodical attack disease of migraine Shi Yileiyou family morbidity tendency.Show as paroxysmal inclined to one side side pulsatile headache, companion feels sick, vomiting and photophobia, again falls ill through one section of after date of having a rest.In peace and quiet, dark surrounds or after sleep, headache is alleviated.Can be with neural, mental function disorder before headache occurs or while outbreak.

The migrainous cause of disease is still not clear, may be relevant with following factors: 1. endogenous cause of ill: migraine has genetic predisposition, and migraineur has family history, and its relatives occur that migrainous risk is 3～6 times of population.Primary disease women is more than male, and how in adolescence morbidity, menstrual phase is easily shown effect, and after trimester of pregnancy or menopause, outbreak reduces or stops.This explanation E&M factor participates in migrainous morbidity.2. exopathogenic factor: environmental factors also participates in migrainous outbreak.Migraine can be brought out by some food and medicine.Food comprises the chocolate that contains the cheese of tyramine, the meat that contains nitrite and cure foods, contain phenethylamine, food additive and the wine etc. that contains sodium glutamate; Medicine comprises that oral contraceptive and vasodilation are as nitroglycerin etc.In addition, high light, overwork, stress and stress after loosen, hypersomnia or very few, fasting, anxiety, emotional lability etc. be also migrainous risk factor.

In the invention of the migrainous Chinese medicine of existing treatment, Granted publication CN 103041339 B(application numbers 201210578199.7) disclose one and treated migrainous Chinese medicine composition, it is mainly made up of the Chinese crude drug of following weight portion: flowers of Edgeworthia chrysantha Lindl 20-30 part, Spica Prunellae 20-30 part, Flos Chrysanthemi Indici 20-30 part, Fructus Viticis Negundo 15-20 part, Rhizoma Cyperi 10-15 part, Fructus Arctii 8-12 part, Flos Farfarae 5-12 part, Flos Lonicerae 3-10 part, Radix Platycodonis 5-7 part, Herba Pogostemonis 2-5 part, Rhizoma Zingiberis Recens 2-6 part, Caulis Bambusae In Taenia 4-8 part, Herba Asari 3-8 part, Semen Benincasae 3-7 part, Semen Persicae 3-5 part, Fructus Foeniculi 1-3 part, Fructus Piperis Longi 1-3 part, Fructus Toosendan 1-3 part, Radix Asteris 1-3 part.Granted publication CN 102302751 B(application numbers 201110238307.1) disclose one and treated migrainous Chinese medicine, raw material by following parts by weight is made: Rhizoma Panacis Japonici 5-10 Fen ， Fructus Mangifera Indicae root 3-5 part, Herba Artemisiae Anomalae 10-12 part, Herba Salomoniae Cantoniensis 4-6 part, Folium Baeckeae 4-6 part, Rhizoma Cyperi 15-20 part, Radix Saposhnikoviae 3-5 part, Radix Angelicae Sinensis 3-5 part, Herba Asari 1-3 part, Radix Angelicae Dahuricae 3-5 part, Rhizoma Et Radix Notopterygii 3-5 part, Radix Angelicae Pubescentis 3-5 part, Radix Glycyrrhizae 1-3 part, Rhizoma Atractylodis 3-5 part, Radix Ophiopogonis 3-5 part, Radix Scutellariae 4-6 part, Fructus Viticis 2-4 part, Flos Chrysanthemi 2-4 part, Rhizoma Zingiberis Recens fresh goods 6-8 part.Granted publication CN 102579986 B(application numbers 201210060255.8) disclose one and treated the migrainous Chinese medicine ache relieving mixture of dispelling, selection has Anemarrhena asphodeloides Bge, Semen Cassiae, Flos Chrysanthemi, Caulis Sargentodoxae, Cortex Moutan, Radix Aconiti, Fructus Citri Sarcodactylis, Bulbus Allii Macrostemonis, Radix Curcumae, Caulis Polygoni Multiflori, Semen Astragali Complanati, the Bulbus Lilii of nourishing YIN and supplementing blood, suppressing the hyperactive liver and subsiding YANG, promoting blood circulation, dredging meridian and relieving pain, makes mixture by traditional method.

Summary of the invention

For migrainous present situation, the object of the present invention is to provide one to treat migrainous Chinese medicinal formulae and preparation method thereof, the present invention develops in conjunction with clinical experience on the basis treating at traditional differential diagnosis in tcm, have the advantages that determined curative effect, instant effect, cure rate are high, have no side effect, can treating both the principal and secondary aspects of a disease ground treatment migraine, recurrence that healing person follows up a case by regular visits to that so far there are no.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Treat migrainous Chinese medicinal formulae, take off the primary raw material of stating weight proportion and be prepared from: Radix Angelicae Dahuricae 10-16 part, Rhizoma Gastrodiae 4-8 part, Clematis filamentosa Dunn 12-20 part, Scorpio 2-7 part, Fructus Viticis 6-12 part, Bombyx Batryticatus 3-9 part, Herba Schizonepetae 8-12 part, Rhizoma Chuanxiong 8-14 part, Rhizoma Paridis tetraphyllae 4-13 part.

The migrainous Chinese medicinal formulae of above-mentioned treatment, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: Radix Angelicae Dahuricae 12-14 part, Rhizoma Gastrodiae 5-7 part, Clematis filamentosa Dunn 14-18 part, Scorpio 3-6 part, Fructus Viticis 8-10 part, Bombyx Batryticatus 5-7 part, Herba Schizonepetae 9-11 part, Rhizoma Chuanxiong 9-13 part, Rhizoma Paridis tetraphyllae 6-11 part.

The above treats migrainous Chinese medicinal formulae, and better preferred scheme is taken off the primary raw material of stating weight proportion and is prepared from: 13 parts of the Radixs Angelicae Dahuricae, 6 parts, Rhizoma Gastrodiae, 16 parts of Clematis filamentosa Dunn, 5 parts of Scorpios, 9 parts of Fructus Viticises, 6 parts of Bombyx Batryticatus, 10 parts of Herba Schizonepetaes, 11 parts of Rhizoma Chuanxiongs, 9 parts of Rhizoma Paridis tetraphyllae.

According to the migrainous Chinese medicinal formulae of arbitrary described treatment above, be prepared into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.

According to the migrainous Chinese medicinal formulae of described treatment above, the preparation method of unguentum, step is as follows:

1. Rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120-140 mesh sieve (preferably 130 mesh sieves);

2. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 20-80 DEG C of water, soak 1-4 hour;

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6-12 times of water gaging (preferably amount of water to 9 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.05-1.5(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.

According to preparation method recited above, preferred scheme is that 2. step uses the water (preferably 50 DEG C) of 30-70 DEG C.

According to preparation method recited above, preferred scheme is that 2. step soaks 2-3 hour (preferably 2.5 hours).

According to preparation method recited above, preferred scheme is that 3. step is concentrated into the preferred relative density to 1.25 of relative density 1.1-1.4().

According to the migrainous Chinese medicinal formulae of described treatment above, the preparation method of granules of sugar agent, step is as follows:

rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120-140 mesh sieve (preferably 130 mesh sieves);

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 20-80 DEG C of (preferably 50 DEG C) water, soak 1-4 hour (preferably 2.5 hours);

3. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6-12 times of water gaging (preferably amount of water to 9 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mixes, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste of (preferred relative density to 1.25), be cooled to room temperature;

3. adding ethanol in gained clear paste to step makes to reach 60% containing alcohol amount, leave standstill, getting supernatant concentration to relative density is 1.2-1.8(60 DEG C) thick paste of (preferably relative density to 1.5), add cane sugar powder, dextrin and appropriate ethanol soft material processed, cross 10-24 mesh sieve granule processed (preferably 17 mesh sieves), wet granular is dry in 40-80 DEG C (preferably 60 DEG C), and dry granule is crossed 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, medicament gets product.

According to the migrainous Chinese medicinal formulae of described treatment above, the preparation method of sugar free granule, step is as follows:

rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120-140 mesh sieve (preferably 130 mesh sieves);

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 20-80 DEG C of (preferably 50 DEG C) water, soak 1-4 hour (preferably 2.5 hours);

3. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6-12 times of water gaging (preferably amount of water to 9 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mixes, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste of (preferred relative density to 1.25), be cooled to room temperature;

3. add ethanol in gained clear paste to step and make to reach 60% containing alcohol amount, leave standstill, get supernatant concentration and become relative density 1.6-1.8(60 DEG C) thick paste of (preferably relative density to 1.7), add dextrin, steviosin is appropriate, mixes, spraying is dry, with a sieve, No. five screening grains, obtain sugar-free granule.

Treat migrainous Chinese medicinal formulae, the pharmacological effect of each raw material is respectively:

The Radix Angelicae Dahuricae: pungent, temperature.Return lung, spleen, stomach warp.Effect: expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis.Cure mainly headache due to common cold, supraorbital bone pain, toothache, nasal obstruction, nasal sinusitis, domination of damp pathogen chronic diarrhea, leucorrhea with red and white discharge, ulcer sores.

Rhizoma Gastrodiae: sweet, pungent, flat.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.

Clematis filamentosa Dunn: be the leaf of Ranunculaceae Actions of Clematis Species silk Radix clematidis floridae.The property of medicine: " national Chinese herbal medicine compilation ": " sweet, micro-cool." effect: " national Chinese herbal medicine compilation ": " (leaf) calmness, analgesia, blood pressure lowering.Cure mainly pink eye disease, headache, hypertension.”

Scorpio: all for Buthidae Buthus animal Scorpio.The property of medicine: salty, pungent, flat, poisonous.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Cure mainly child convulsion and twitch, epilepsy, apoplexy and hemiplegia, Kou Yan is oblique, migraine and general headache, rheumatoid arthritis stubborn, lockjaw, scrofula subcutaneous nodule, rubella pyogenic infections.

Fructus Viticis: be the fruit of Verenaceae Vitex species Vitex rotundifolia and wild pepper.The property of medicine: pungent, bitter, be slightly cold, nontoxic.Return lung, liver, stomach warp.Effect: dispelling wind and heat pathogens, the clear sharp head.Cure mainly affection due to external wind and heat, dizzy headache, migraine, gingival swelling and pain, the many tear of conjunctival congestion and swelling pain, pain in order eyeball, dim not clear, arthralgia chiefly caused by damp pathogen contracture.

Bombyx Batryticatus: the larva that belongs to animal bombyx mori for Bombycidae silkworm infects the ossified Scorpio of muscardine.The property of medicine: pungent, salty, flat.Return liver, lung, stomach warp.Effect: expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat.Cure mainly infantile convulsion, twitch, middle wind-eye mouth is crooked, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore.

Herba Schizonepetae: be the spica of Labiatae Schizonepeta tenuifolia platymiscium Herba Schizonepetae and many lobed leaf Herba Schizonepetae.The property of medicine: pungent, micro-hardship, tepor.Return lung, Liver Channel.Effect: dispel the wind, induce sweat, rash, hemostasis.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, skin ulcer scabies, epistaxis, spits blood, has blood in stool, metrorrhagia, puerperal blood faints.

Rhizoma Chuanxiong: be the rhizome of Umbelliferae Ligustrum plant Rhizoma Chuanxiong.The property of medicine: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.Cure mainly menoxenia, amenorrhea dysmenorrhoea, the stagnant stomachache of the stasis of blood in puerperal ， mass in the abdomen lump, costa sternales pain, has a headache dizzy, wind and cold arthralgia pain, traumatic injury, ulcer sores.

Rhizoma Paridis tetraphyllae: be the rhizome of Liliaceae paris plant Paris bashanensis Wang et Tang.The property of medicine: hardship, pungent, temperature.Effect: expelling cold and dampness, removing obstruction in the collateral to relieve pain, hemostasia and promoting granulation.Cure mainly chronic arthralgia caused by cold-damp, chills and pain of the waist and kness, traumatic hemorrhage.

The present invention is by after said medicine combination, drug effect has synergism, there is dispelling wind and removing obstruction in the collateral, the clear sharp head, blood circulation promoting and blood stasis dispelling, effect of activating QI to alleviate the depression, cause for migraine feel sick, the symptom such as vomiting has significant curative effect, there is long-acting, quick-acting and efficient feature, migraine and symptom thereof are reached to the object for the treatment of both the principal and secondary aspects of a disease.In addition, excellent results of the present invention also shows:

1,the medical material of multiselect medication heat warm in nature, neutralizes other cold and cool medical materials, after taking, can not be harmful to the health;

2,made dosage form is common formulations pharmaceutically, more easily absorbs, therefore it is faster to take effect than Chinese medicine method for making.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1treat migrainous Chinese medicinal formulae, take off the primary raw material of stating weight proportion and be prepared from (getting 10g for every part): 12 parts of the Radixs Angelicae Dahuricae, 5 parts, Rhizoma Gastrodiae, 14 parts of Clematis filamentosa Dunn, 3 parts of Scorpios, 8 parts of Fructus Viticises, 5 parts of Bombyx Batryticatus, 9 parts of Herba Schizonepetaes, 9 parts of Rhizoma Chuanxiongs, 6 parts of Rhizoma Paridis tetraphyllae.

The migrainous Chinese medicinal formulae of above-mentioned treatment, the preparation method of unguentum, step is as follows:

1. Rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120 mesh sieves;

2. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 30 DEG C of water, soak 2 hours;

3. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6 times of water gagings at every turn, respectively decoct 3 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.05(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.

typical case onegrandson XX, female, 25 years old, civilian.Paroxysmal right side migraine 2 months, often feels tired, inappetence, yawn repeatedly, insomnia and dreamful sleep.Because operating pressure increases burst one side local pain, diffuse to gradually head pain half in the recent period, have a headache for throbbing pain, occur anorexia, vomiting, nauseating, photophobia phonophobia.Confirm as after diagnosing migraine.Taking Western medicine changes after invalid and takes medicament of the present invention.

Embodiment 1 gained unguentum boiled water is taken after mixing it with water, one after each meal, every day early, middle and late respectively taking 1 time, a 25ml, 15 days is a course for the treatment of, uses 25 days, right side migraine number of times obviously reduces, without vomiting, feel sick symptom.Use 50 days pain no longer to occur, it is normal that appetite is recovered, and follows up a case by regular visits to no longer recurrence.

embodiment 2treat migrainous Chinese medicinal formulae, take off the primary raw material of stating weight proportion and be prepared from (getting 5g for every part): 14 parts of the Radixs Angelicae Dahuricae, 7 parts, Rhizoma Gastrodiae, 18 parts of Clematis filamentosa Dunn, 6 parts of Scorpios, 10 parts of Fructus Viticises, 7 parts of Bombyx Batryticatus, 11 parts of Herba Schizonepetaes, 13 parts of Rhizoma Chuanxiongs, 11 parts of Rhizoma Paridis tetraphyllae.

The migrainous Chinese medicinal formulae of above-mentioned treatment, the preparation method of unguentum, step is as follows:

1. Rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 140 mesh sieves;

2. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 70 DEG C of water, soak 3 hours;

3. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 12 times of water gagings at every turn, respectively decoct 5 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.5(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.

typical case twoweek XX, man, 35 years old, workman.Suffer from paroxysmal left side migraine more than 6 years.Taking left side temple as main, jumping pain, comparatively serious when sleep is poor, monthly pain 3～4 times, has persistence.Often there is scintillation dim spot at the moment in nearly two weeks, prickling sensation appears in face, and throbbing pain number of times increases to some extent, to light, sound and abnormal smells from the patient sensitivity, likes dark, quiet environment, and with anorexia, the symptoms such as vexed dreaminess.After being diagnosed as migraine, hospital takes unguentum of the present invention.

Embodiment 2 gained unguentum boiled water are taken after mixing it with water, every day early, middle and late respectively taking 1 time, a 30ml, 15 days is a course for the treatment of, uses 30 days, the vexed symptom of anorexia disappears substantially.Take 60 days, sensation migraine is fully recovered, no longer morbidity.Between the operating period, occur without malaise symptoms.After half a year, follow up a case by regular visits to, not recurrence.

embodiment 3treat migrainous Chinese medicinal formulae, take off the primary raw material of stating weight proportion and be prepared from (getting 15g for every part): 13 parts of the Radixs Angelicae Dahuricae, 6 parts, Rhizoma Gastrodiae, 16 parts of Clematis filamentosa Dunn, 5 parts of Scorpios, 9 parts of Fructus Viticises, 6 parts of Bombyx Batryticatus, 10 parts of Herba Schizonepetaes, 11 parts of Rhizoma Chuanxiongs, 9 parts of Rhizoma Paridis tetraphyllae.

Above-mentioned migrainous Chinese medicinal formulae, the preparation method of unguentum, step is as follows:

1. Rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 130 mesh sieves;

2. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 50 DEG C of water, soak 2.5 hours;

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 9 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into relative density and are about 1.25(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.

typical case threezheng XX, female, 42 years old, worker.Near patient's readme point of fixation, often there is "the" shape flash of light, and gradually to circumferential expansion, there is subsequently " zigzag " dim spot, blurred vision, right side temples drilling pain pain, and with sweating, bitter taste, flushing, thirsty, dark tongue quality, the symptom such as tongue is white, body is bigger, deep and stringy pulse.Patient is because pain takes place frequently, so that endurable, then goes to see a doctor, and is diagnosed as migraine.

Embodiment 3 gained unguentum boiled water are taken after mixing it with water, one after each meal, every day early, middle and late respectively taking 1 time, a 40ml, 15 days is a course for the treatment of, uses after 30 days, depending on thing normal, headache outbreak reduces, perspire few, red tongue, tongue white spirit.Take 55 days, headache is not reaccessed, other transference cures.Follow up a case by regular visits to without recurrence.

embodiment 4treat migrainous Chinese medicinal formulae, take off the primary raw material of stating weight proportion and be prepared from (getting 15g for every part): 13 parts of the Radixs Angelicae Dahuricae, 6 parts, Rhizoma Gastrodiae, 16 parts of Clematis filamentosa Dunn, 5 parts of Scorpios, 9 parts of Fructus Viticises, 6 parts of Bombyx Batryticatus, 10 parts of Herba Schizonepetaes, 11 parts of Rhizoma Chuanxiongs, 9 parts of Rhizoma Paridis tetraphyllae.

The migrainous Chinese medicinal formulae of above-mentioned treatment, the preparation method of granules of sugar agent, step is as follows:

1. Rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 130 mesh sieves;

2. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 50 DEG C of water, soak 2.5 hours;

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 9 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, then be concentrated into relative density and be about 1.25(60 DEG C) clear paste, be cooled to room temperature;

3. adding ethanol in gained clear paste to step makes to reach 60% containing alcohol amount, leave standstill, getting supernatant concentration to relative density is 1.5(60 DEG C) thick paste, add cane sugar powder, dextrin and appropriate ethanol soft material processed, cross 17 mesh sieve granule processed, wet granular in 60 DEG C dry, dry granule is crossed the 17 mesh sieve granulate medicament that gets product.

typical case fourwei XX, female, 65 years old, cadre.Burst bilatenal headache, ophthalmoplegia, tinnitus aphasia, paraesthesia, there is obstacle in spirit.Morning on the one get up burst one side severe headache, with nausea and vomiting, shed tears, nasal obstruction and toothache, headache is for non-pulsation, after in outbreak in many days mornings, walk, step on the simple activities such as building, cough or sneeze and all can increase the weight of headache, patient is many, and happiness is lain up, and photophobia phonophobia, does not like and gos out.

In embodiment 4, gained granules of sugar agent boiled water is taken after mixing it with water, one after each meal, and every day, early, middle and late respectively taking 1 time, wrapped for one time 3, within 15 days, was a course for the treatment of, used after 25 days, and pain is alleviated to some extent and attack times reduces, life normal; Take after 40 days, pain perception disappears.Follow up a case by regular visits to 1 year, not recurrence.

embodiment 5treat migrainous Chinese medicinal formulae, take off the primary raw material of stating weight proportion and be prepared from (getting 15g for every part): 13 parts of the Radixs Angelicae Dahuricae, 6 parts, Rhizoma Gastrodiae, 16 parts of Clematis filamentosa Dunn, 5 parts of Scorpios, 9 parts of Fructus Viticises, 6 parts of Bombyx Batryticatus, 10 parts of Herba Schizonepetaes, 11 parts of Rhizoma Chuanxiongs, 9 parts of Rhizoma Paridis tetraphyllae.

The migrainous Chinese medicinal formulae of above-mentioned treatment, the preparation method of sugar free granule, step is as follows:

1. Rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 130 mesh sieves;

2. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 50 DEG C of water, soak 2.5 hours;

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 9 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, then be concentrated into relative density and be about 1.25(60 DEG C) clear paste, be cooled to room temperature;

3. add ethanol in gained clear paste to step and make to reach 60% containing alcohol amount, leave standstill, get supernatant concentration and become relative density 1.7(60 DEG C) thick paste, add dextrin, steviosin is appropriate, mixes, spraying is dry, with a sieve, No. five screenings, can obtain sugar-free granule.

experimental examplein order to verify that Chinese medicinal formulae of the present invention has definite curative effect to treatment migraine, to randomly draw 160 and suffered from migrainous diabetics, the mean age is 45 years old, minimum 35 years old, maximum 70 years old, each 80 people of men and women.Be divided into experimental group and matched group according to the state of an illness and pathology, every group of each 80 people, 40 male patients, 40 female patients, guarantee that experimental group and matched group situation are basically identical.

Experimental group uses the embodiment of the present invention 5 gained sugar free granule every day, and for making sugar free granule of the present invention reach optimum therapeuticing effect, sugar free granule boiled water is taken after mixing it with water, one after each meal, every day early, middle and late respectively taking 1 time, 2-3 bag, 15 days is a course for the treatment of.Matched group uses the migrainous medicine of other treatment (as migrainous medicines of conventional therapy such as Zolmitriptan sheet, diclofenac potassium tablets).Criterion: 1. cure: migraine and relevant symptoms all disappear, do not affect life and work, follow up a case by regular visits to half a year without recurrence; effective: migraine and relevant symptoms disappear substantially, after treatment, symptom obviously alleviates, and does not affect daily life and work; 3. effective: relevant symptoms and sign are improved, but unstable condition has recurrence after drug withdrawal; 4. invalid: unchanged or counter the increasing the weight of of clinical symptoms and sign.

Observe 60 days time limits, observed once every 10 days, record respectively efficiently individual quantity, healing number and have the number of untoward reaction.

Matched group takes the migrainous medicine of other treatment and experimental group is taken sugar free granule Comparison of therapeutic of the present invention, and result is as shown in table 1:

Table 1

Analyze: as can be seen from Table 1, take and use sugar free granule effective percentage of the present invention up to 97.5%, cure rate, up to 94%, untoward reaction does not occur.Successful is better than taking the migrainous medicine of other treatment.

Experimental group (sugar free granule of the present invention) and matched group all can reach the object easing the pain fast in 60 days of the observation period, but the untoward reaction that there will be the side effect such as nauseating, dizzy, drowsiness, unable, xerostomia to cause in matched group after some patients were drug administration.Sugar free granule of the present invention adopts Chinese medicinal material simple and easy to get as raw material, has the advantages that determined curative effect, instant effect, cure rate are high, have no side effect, and migraine and symptom thereof is reached to the object for the treatment of both the principal and secondary aspects of a disease.

Claims (10)

1. the migrainous Chinese medicinal formulae for the treatment of, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Angelicae Dahuricae 10-16 part, Rhizoma Gastrodiae 4-8 part, Clematis filamentosa Dunn 12-20 part, Scorpio 2-7 part, Fructus Viticis 6-12 part, Bombyx Batryticatus 3-9 part, Herba Schizonepetae 8-12 part, Rhizoma Chuanxiong 8-14 part, Rhizoma Paridis tetraphyllae 4-13 part.

2. treat according to claim 1 migrainous Chinese medicinal formulae, it is characterized in that, taking off the primary raw material of stating weight proportion is prepared from: Radix Angelicae Dahuricae 12-14 part, Rhizoma Gastrodiae 5-7 part, Clematis filamentosa Dunn 14-18 part, Scorpio 3-6 part, Fructus Viticis 8-10 part, Bombyx Batryticatus 5-7 part, Herba Schizonepetae 9-11 part, Rhizoma Chuanxiong 9-13 part, Rhizoma Paridis tetraphyllae 6-11 part.

3. treat according to claim 1 migrainous Chinese medicinal formulae, it is characterized in that, take off the primary raw material of stating weight proportion and be prepared from: 13 parts of the Radixs Angelicae Dahuricae, 6 parts, Rhizoma Gastrodiae, 16 parts of Clematis filamentosa Dunn, 5 parts of Scorpios, 9 parts of Fructus Viticises, 6 parts of Bombyx Batryticatus, 10 parts of Herba Schizonepetaes, 11 parts of Rhizoma Chuanxiongs, 9 parts of Rhizoma Paridis tetraphyllae.

4. treat according to claim 1 migrainous Chinese medicinal formulae, it is characterized in that, be prepared into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.

5. Chinese medicinal formulae according to claim 4, is characterized in that, the preparation method of described unguentum is as follows:

rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120-140 mesh sieve (preferably 130 mesh sieves);

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 20-80 DEG C of water, soak 1-4 hour;

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6-12 times of water gaging (preferably amount of water to 9 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder are mixed, and are then concentrated into the clear paste that relative density is about 1.05-1.5, be cooled to room temperature, sterile packaged obtains unguentum.

6. preparation method according to claim 5, is characterized in that, 2. step uses the water (preferably 50 DEG C) of 30-70 DEG C.

7. preparation method according to claim 5, is characterized in that, 2. step soaks 2-3 hour (preferably 2.5 hours).

8. preparation method according to claim 5, is characterized in that, 3. step is concentrated into the preferred relative density to 1.25 of relative density 1.1-1.4().

9. Chinese medicinal formulae according to claim 4, is characterized in that, the preparation method of described granules of sugar agent is:

rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120-140 mesh sieve (preferably 130 mesh sieves);

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 20-80 DEG C of (preferably 50 DEG C) water, soak 1-4 hour (preferably 2.5 hours);

3. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6-12 times of water gaging (preferably 9 times of amount of water) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about the preferred relative density to 1.25 of 1.05-1.5() clear paste, be cooled to room temperature;

3. adding ethanol in gained clear paste to step makes to reach 60% containing alcohol amount, leave standstill, getting supernatant concentration to relative density is the preferred relative density to 1.6 of 1.2-1.8() thick paste, add cane sugar powder, dextrin and appropriate ethanol soft material processed, cross 10-24 mesh sieve granule processed (preferably 17 mesh sieves), wet granular is dry in 40-80 DEG C (preferably 60 DEG C), and dry granule is crossed 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, medicament gets product.

10. Chinese medicinal formulae according to claim 4, is characterized in that, the preparation method of described sugar free granule is as follows:

rhizoma Gastrodiae, Clematis filamentosa Dunn, Fructus Viticis, Herba Schizonepetae are cleaned, pulverized, cross 120-140 mesh sieve (preferably 130 mesh sieves);

the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae are removed to impurity, clean, in 20-80 DEG C of (preferably 50 DEG C) water, soak 1-4 hour (preferably 2.5 hours);

3. the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Scorpio, Bombyx Batryticatus, Rhizoma Paridis tetraphyllae after soaking are decocted with water 2 times, add 6-12 times of water gaging (preferably amount of water to 9 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then merge medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about the preferred relative density to 1.25 of 1.05-1.5() clear paste, be cooled to room temperature;

3. add ethanol in gained clear paste to step and make to reach 60% containing alcohol amount, leave standstill, get supernatant concentration and become the preferred relative density to 1.7 of relative density 1.6-1.8() thick paste, add dextrin, steviosin is appropriate, mixes, spraying is dry, with a sieve, No. five screening grains, obtain sugar-free granule.