CN103908583B - One treats prosopalgic Chinese medicine preparation and preparation method thereof - Google Patents

One treats prosopalgic Chinese medicine preparation and preparation method thereof Download PDF

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CN103908583B
CN103908583B CN201410157080.1A CN201410157080A CN103908583B CN 103908583 B CN103908583 B CN 103908583B CN 201410157080 A CN201410157080 A CN 201410157080A CN 103908583 B CN103908583 B CN 103908583B
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rhizoma
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chinese medicine
scorpio
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CN103908583A (en
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李延辉
王风云
金瑞峰
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Li Yanhui
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Priority to CN201510872106.5A priority Critical patent/CN105395904A/en
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Priority to CN201510872254.7A priority patent/CN105395906A/en
Priority to CN201410157080.1A priority patent/CN103908583B/en
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Abstract

The present invention relates to one and treat prosopalgic Chinese medicine preparation and preparation method thereof, mainly take off the raw material stating weight proportion to be prepared from: Radix Astragali 6-9 part, Rhizoma Acori Graminei 10-15 part, Rhizoma Gastrodiae 3-6 part, Scorpio 1-5 part, Bombyx Batryticatus 1-5 part, Fructus Bruceae 10-20 part, Herba Schizonepetae 10-25 part, Rhizoma Paridis tetraphyllae's 5-15 part, Tupistra chinensis Bak. 8-16 part.The present invention has determined curative effect, instant effect, cure rate is high, the feature that has no side effect, it is possible to effectively treat trigeminal neuralgia.

Description

One treats prosopalgic Chinese medicine preparation and preparation method thereof
Technical field
The present invention relates to one and treated prosopalgic Chinese medicine preparation and preparation method thereof, belonged to traditional Chinese medicine field, be mainly used in treatment trigeminal neuralgia.
Background technology
Trigeminal neuralgia is modal cranial nerve diseases, it is also sometimes referred to as " face pain ", being a kind of violent neuralgia of paroxysmal of recurrent exerbation in face nervi trigeminus areal area, trigeminal neuralgia is one of neurosurgery commonly encountered diseases, is also one of internationally recognized difficult miscellaneous diseases.Most trigeminal neuralgia morbidities in 40 years old, multiple middle-aged and elderly people of being born in, women is especially many, its R)L of falling ill, the feature of this disease is: in Head And Face nervi trigeminus distributed areas, and morbidity is rapid to be sent out, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speaking, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking, therefore affected nerves of patients with trigeminal neuralgia often dare not wipe face, feed, and even saliva also dare not be swallowed, thus affecting normal live and work.There is this pain of person for " the first under heaven pain ".
Trigeminal neuralgia can be divided into constitutional (symptomatic) trigeminal neuralgia and the big class of secondary trigeminal neuralgia two, and wherein primary trigeminal neuralgia is more typically.Primary trigeminal neuralgia: refer to the trigeminal neuralgia that can not find the definite cause of disease.It is likely due to the supply hardening of blood vessel and pressuring nerve causes, it is also possible to be because that meninges thickens, nerve passes through bone hole is narrow causes compressing to cause pain.Secondary trigeminal neuralgia: refer to the trigeminal neuralgia owing to oncothlipsis, inflammation, vascular malformation cause.This kind of is different from idiopathic feature, and pain is often in persistence, and can find the pathological changes sign of nervi trigeminus proximity structure.
In the invention of the prosopalgic Chinese medicine preparation of existing treatment, Authorization Notice No. CN102847125B(application number 201210362059.6) disclose one and treat prosopalgic medicine and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Radix Rehmanniae, Rhizoma Cimicifugae, Radix Ginseng, Herba Menthae, Rhizoma Arisaematis, Rhizoma Gastrodiae, Rhizoma Alismatis, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae, the Rhizoma Pinelliaes.Authorization Notice No. CN102961450B(application number 201210539444.3) disclose one and treat prosopalgic Chinese medicine composition, this Chinese medicine composition is by Caulis et folium stauntoniae, Marasmius equicrinis Muell., Folium Sennae, Radix Stephaniae Cepharanthae, Rhizoma Chuanxiong, Rhizoma Corydalis, Radix Cynanchi Auriculati, Radix Dipsaci, Squama Manis, Nidus Vespae, Radix Glycyrrhizae is made.Authorization Notice No. CN102357238B(application number 201110328707.1) disclose one and treat prosopalgic Chinese medicine composition, it is made up of the raw material of following weight: Fructus Evodiae 8-10 gram, Radix Ginseng 9-15 gram, 9-15 gram of Rhizoma Zingiberis Recens, 9-15 gram of Fructus Jujubae, Radix Asparagi 4-8 gram, Radix Ophiopogonis 4-8 gram, Rhizoma Cimicifugae 1-5 gram, Bidens paruiflora Willd. 4-8 gram, Pericarpium Papaveris 4-8 gram, Semen Persicae mud 1-3 gram, 1-3 gram of Flos Carthami, Semen Pruni Salicinae 8-1 gram, 4-6 gram of Rhizoma Gastrodiae.
Summary of the invention
For prosopalgic present situation, it is an object of the invention to provide one and treat prosopalgic Chinese medicine preparation and preparation method thereof, the present invention develops in conjunction with clinical experience on the basis that traditional differential diagnosis in tcm treats, have determined curative effect, instant effect, cure rate is high, the feature that has no side effect, it is possible to effectively treat trigeminal neuralgia.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from: Radix Astragali 6-9 part, Rhizoma Acori Graminei 10-15 part, Rhizoma Gastrodiae 3-6 part, Scorpio 1-5 part, Bombyx Batryticatus 1-5 part, Fructus Bruceae 10-20 part, Herba Schizonepetae 10-25 part, Rhizoma Paridis tetraphyllae's 5-15 part, Tupistra chinensis Bak. 8-16 part.
The prosopalgic Chinese medicine preparation of above-mentioned treatment, it is preferred that scheme, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 7-8 part, Rhizoma Acori Graminei 11-14 part, Rhizoma Gastrodiae 4-5 part, Scorpio 2-4 part, Bombyx Batryticatus 2-4 part, Fructus Bruceae 13-17 part, Herba Schizonepetae 15-20 part, Rhizoma Paridis tetraphyllae's 9-11 part, Tupistra chinensis Bak. 10-14 part.
The above treats prosopalgic Chinese medicine preparation, and more preferably preferred scheme, takes off the primary raw material stating weight proportion and be prepared from: the Radix Astragali 8 parts, Rhizoma Acori Graminei 13 parts, 5 parts of Rhizoma Gastrodiae, Scorpio 3 parts, Bombyx Batryticatus 3 parts, Fructus Bruceae 15 parts, Herba Schizonepetae 18 parts, Rhizoma Paridis tetraphyllae 10 parts, Tupistra chinensis Bak. 12 parts.
According to above arbitrary prosopalgic Chinese medicine preparation of described treatment, prepare into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.
According to the prosopalgic Chinese medicine preparation for the treatment of described above, the preparation method of unguentum, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 100-160 mesh sieve (preferably 130 mesh sieve)；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 1-4 hour in 30-60 DEG C of water；
3. by the Scorpio after immersion, Bombyx Batryticatus boiling 2 times, add 4-10 times amount water (preferred amount of water is to 7 times) every time, each pan-fried 3-5 hour (preferably 4 hours), it is then combined with medicinal liquid, filtering, filtrate and step 1. middle gained medicated powder mixes, and is then concentrated into relative density and is about 1.05-1.5(60 DEG C) clear paste, being cooled to room temperature, sterile packaged obtains unguentum.
According to preparation method recited above, it is preferred that scheme is, step is 2. with the water (preferably 45 DEG C) of 40-50 DEG C.
According to preparation method recited above, it is preferred that scheme is, 2. step soaks 2-3 hour (preferably 2.5 hours).
According to preparation method recited above, it is preferred that scheme is, 3. step is concentrated into the preferred relative density of relative density 1.1-1.4(to 1.25).
According to the prosopalgic Chinese medicine preparation for the treatment of described above, the preparation method of granules of sugar agent, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 100-160 mesh sieve (preferably 130 mesh sieve)；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, in 30-60 DEG C of (preferably 45 DEG C) water, soak 1-4 hour (preferably 2.5 hours)；
3. by the Scorpio after immersion, Bombyx Batryticatus boiling 2 times, add 4-10 times amount water (preferred amount of water 7 times) every time, each pan-fried 3-5 hour (preferably 4 hours), it is then combined with medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste, be cooled to room temperature；
4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stand, take supernatant concentration and be 1.2-1.8(60 DEG C to relative density) thick paste of (preferred relative density to 1.5), add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 10-24 mesh sieve granule (preferably 17 mesh sieve), wet granular dries in 40-80 DEG C (preferably 60 DEG C), and dry granule crosses 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, checking, packaging, get product medicament.
According to the prosopalgic Chinese medicine preparation for the treatment of described above, the preparation method of sugar free granule, step is as follows:
1. by the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. is cleaned, and pulverizes, and crosses 100-160 mesh sieve (preferably 130 mesh sieve)；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, in 30-60 DEG C of (preferably 45 DEG C) water, soak 1-4 hour (preferably 2.5 hours)；
3. by the Scorpio after immersion, Bombyx Batryticatus boiling 2 times, add 4-10 times amount water (preferred amount of water is to 7 times) every time, each pan-fried 3-5 hour (preferably 4 hours), it is then combined with medicinal liquid, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste of (preferred relative density to 1.25), be cooled to room temperature；
4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stands, and takes supernatant concentration and becomes the preferred relative density of relative density 1.6-1.8(to 1.7) thick paste of (60 DEG C), add dextrin, steviosin in right amount, mixing, spray drying, with a sieve, No. five screening grains, obtain sugar-free granule.
Treating prosopalgic Chinese medicine preparation, the pharmacological effect of each raw material is respectively as follows:
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Effect: benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Curing mainly the card of all Qi and blood deficiencies, such as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back.
Rhizoma Acori Graminei: for the rhizome of Acorus of Araceae phytobezoar Rhizoma Acori Graminei.The property of medicine: pungent, bitter, tepor, GUIXIN, liver, spleen channel.Effect: eliminate phlegm for resuscitation, removing dampness to restore normal function of the stomach, mind calming benefit will.Cure mainly calentura coma, syncope due to accumulation of phlegm, forgetful, insomnia, tinnitus, deaf, fasting dysentery, rheumatic arthralgia.
Rhizoma Gastrodiae: sweet, pungent is flat.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizziness, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.
Scorpio: for the entirety of Buthidae Buthus animal Scorpio.The property of medicine: salty, pungent, flat, poisonous.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Curing mainly infantile convulsion to twitch, epilepsy, apoplexy and hemiplegia, mouth eye is oblique, migraine and general headache, rheumatoid arthritis stubborn, tetanus, scrofula sucutaneous nodule, rubella toxic swelling.
Bombyx Batryticatus: the larva belonging to animal bombyx mori for Bombycidae silkworm infects muscardine and ossified Scorpio.The property of medicine: pungent, salty, flat.Return liver, lung, stomach warp.Effect: expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat.Curing mainly infantile convulsion, twitch, middle wind-eye mouth is crooked, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore.
Fructus Bruceae: for the fruit of Simarubaceae brucea plant Fructus Bruceae.The property of medicine: bitter, cold.Mild toxicity.Return large intestine, Liver Channel.Effect: heat clearing away, removing toxic substances, parasite killing, preventing the attack (or recurrence) of malaria, loses wart.Cure mainly toxic-heat and blood stasis, cold-dysentery, chronic dysentery with frequent relapse, malaria, hemorrhoid, carbuncle, pudendal pruritus, leucorrhea, wart wart, clavus, venom.
Herba Schizonepetae: for the spica of Labiatae Schizonepeta tenuifolia platymiscium Herba Schizonepetae and many lobed leaf Herba Schizonepetae.The property of medicine: hardship pungent, micro-, tepor.Return lung, Liver Channel.Effect: dispel the wind, induces sweat, rash, hemostasis.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, skin ulcer scabies, epistaxis, spit blood, have blood in stool, metrorrhagia, puerperal blood faints.
Rhizoma Paridis tetraphyllae: for the rhizome of Liliaceae paris plant Paris bashanensis Wang et Tang.The property of medicine: bitter, pungent, temperature.Effect: expelling cold and dampness, removing obstruction in the collateral to relieve pain, hemostasia and promoting granulation.Cure mainly chronic arthralgia caused by cold-damp, chills and pain of the waist and kness, traumatic hemorrhage.
Tupistra chinensis Bak.: for the rhizome of Liliaceae Tupistra plant Tupistra chinensis Bak. and sword-like leave Tupistra chinensis Bak..The property of medicine: bitter, acrid, cold.Poisonous.Effect: heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain.Cure mainly diphtheria, laryngopharynx swelling and pain, rheumatic arthralgia, traumatic injury, stomachache, carbuncle sore tumefacting virus, poisonous snake, lyssodexis.
The present invention provides Chinese medicine preparation scientific formula, and preparation method is simple, products obtained therefrom taking convenience, and can effectively treat trigeminal neuralgia.In addition, the excellent results of the present invention is also manifested by:
1, medicine source is easy to get, cheap, and medical expense is low；
2, the property of medicine is gentle, and dosage form taking convenience, patient is acceptant；
3, used medical material is Chinese medicine material, and toxicity is little, and patient will not cause any actual bodily harm.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 treats prosopalgic Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (every part takes 10g) Radix Astragali 6 parts, Rhizoma Acori Graminei 10 parts, 3 parts of Rhizoma Gastrodiae, Scorpio 1 part, Bombyx Batryticatus 1 part, Fructus Bruceae 10 parts, Herba Schizonepetae 10 parts, Rhizoma Paridis tetraphyllae 5 parts, Tupistra chinensis Bak. 8 parts.
The preparation method of the prosopalgic granules of sugar agent of above-mentioned treatment, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 100 mesh sieves；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 1 hour in 30 DEG C of water；
3. by the Scorpio after soaking, Bombyx Batryticatus boiling 2 times, adding 4 times amount water every time, each decoct 3 hours, be then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, is then concentrated into relative density and is about 1.05(60 DEG C) clear paste, be cooled to room temperature；
4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stand, take supernatant concentration and be 1.2(60 DEG C to relative density) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 10 mesh sieve granules, wet granular dries in 40 DEG C, and dry granule is crossed 17 mesh sieve granulate and got product medicament.
Typical case one Zhao XX, man, 45 years old.Telling right side occiput pain 30 years, right side face electric shock sample pain 6 years, pain position is mainly on the right side of place between the eyebrows.Face and right side bicker sharp ache on the right side of the bridge of the nose, continue ten seconds every time, and outbreak is frequently.Shed tears and sialorrhea with right side eye during panic attacks, facial spasm, conjunctival congestion.Insomnia occurs, it is impossible to feed during serious symptom.Confirm as trigeminal neuralgia after diagnosing.
Embodiment 1 gained granules of sugar agent boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, one time 1 bag, within 10 days, is a course for the treatment of, uses 15 days, and on the right side of the bridge of the nose, facial and right side bicker pain takes a turn for the better to some extent.Use 30 days pain to disappear, follow up a case by regular visits to and no longer recur.
Embodiment 2 treats prosopalgic Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (every part takes 5g): the Radix Astragali 9 parts, Rhizoma Acori Graminei 15 parts, 6 parts of Rhizoma Gastrodiae, Scorpio 5 parts, Bombyx Batryticatus 5 parts, Fructus Bruceae 20 parts, Herba Schizonepetae 25 parts, Rhizoma Paridis tetraphyllae 15 parts, Tupistra chinensis Bak. 16 parts.
The preparation method of the prosopalgic granules of sugar agent of above-mentioned treatment, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 160 mesh sieves；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 4 hours in 60 DEG C of water；
3. by the Scorpio after soaking, Bombyx Batryticatus boiling 2 times, adding 10 times amount water every time, each decoct 5 hours, be then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, is then concentrated into relative density and is about 1.5(60 DEG C) clear paste, be cooled to room temperature；
4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stand, take supernatant concentration and be 1.8(60 DEG C to relative density) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 24 mesh sieve granules, wet granular dries in 80 DEG C, and dry granule is crossed 17 mesh sieve granulate and got product medicament.
Typical case two Wu XX, female, 45 years old, worker.In May, 2013 goes to a doctor.Suffer from primary trigeminal neuralgia more than a year.On the right side of oral cavity, pain acutely taken out by the gingiva position sample that often occurs lancinating, and lasts 1-2 minute every time.Often take phenytoin sodium tablet and Carbamazepine Tablets, maintain not pain reluctantly.Recent feels pain is day by day violent, and the side effect such as drowsiness, dizziness occurs after taking medicine, and then cuts out former medicine, uses Chinese medicine preparation of the present invention instead.
Embodiment 2 gained granules of sugar agent boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, one time 1 bag, within 10 days, is a course for the treatment of, uses 20 days, feels pain alleviates to some extent, has substantially no effect on normal life and work.Taking 40 days, sensation primary trigeminal neuralgia is fully recovered, and no longer falls ill.Occur without malaise symptoms during use.Follow up a case by regular visits to 2 years, do not recur.
Embodiment 3 treats prosopalgic Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (every part takes 30g): the Radix Astragali 7 parts, Rhizoma Acori Graminei 11 parts, 4 parts of Rhizoma Gastrodiae, Scorpio 2 parts, Bombyx Batryticatus 2 parts, Fructus Bruceae 13 parts, Herba Schizonepetae 15 parts, Rhizoma Paridis tetraphyllae 9 parts, Tupistra chinensis Bak. 10 parts.
The preparation method of the prosopalgic unguentum of above-mentioned treatment, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 130 mesh sieves；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 2.5 hours in 45 DEG C of water；
3. by the Scorpio after immersion, Bombyx Batryticatus boiling 2 times, add 7 times amount water every time, each pan-fried 4 hours, being then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, then be concentrated into relative density and be about 1.25(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
Typical case SANHUANG XX, man, 52 years old, peasant.On the right side of main cause, the ictal pain of facial area is gone to a doctor for 1 year, once oral carbamazepine 1, three times on the one, symptom once alleviated, but increased the weight of once again subsequently, and nearly two weeks carrys out patient to be occurred having a dizzy spell, the lumbago soreness of waist, emotion is irritated, and attack times is more frequent, firmly rubs face with palm so that local skin is coarse, thicken, milphae, conjunctival congestion, shed tears and sialorrhea.Medicament of the present invention is taken after hospital is diagnosed as trigeminal neuralgia.
Embodiment 3 gained unguentum boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, and a 50ml, 10 days is a course for the treatment of, after using 30 days, without obvious pain, lumbago soreness of waist symptom seldom occurs.Take 45 days, cure, follow up a case by regular visits to without recurrence.
Embodiment 4 treats prosopalgic Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (every part takes 30g): the Radix Astragali 8 parts, Rhizoma Acori Graminei 14 parts, 5 parts of Rhizoma Gastrodiae, Scorpio 4 parts, Bombyx Batryticatus 4 parts, Fructus Bruceae 17 parts, Herba Schizonepetae 20 parts, Rhizoma Paridis tetraphyllae 11 parts, Tupistra chinensis Bak. 14 parts.
The preparation method of the prosopalgic granules of sugar agent of above-mentioned treatment, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 130 mesh sieves；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 2.5 hours in 45 DEG C of water；
3. by the Scorpio after soaking, Bombyx Batryticatus boiling 2 times, adding 7 times amount water every time, each decoct 4 hours, be then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, is then concentrated into relative density and is about 1.25(60 DEG C) clear paste, be cooled to room temperature；
4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stand, take supernatant concentration and be 1.5(60 DEG C to relative density) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 17 mesh sieve granules, wet granular dries in 50 DEG C, and dry granule is crossed 17 mesh sieve granulate and got product medicament.
Typical case four poplar XX, female, 63 years old, peasant.There are about 4 years medical histories of trigeminal neuralgia, at ordinary times by taking the maintenance of Western medicine carbamazepine, within nearest 1 year, every a few days, the right side bicker swollen sense of acid occurs, how by day, it is impossible to touching, irriate then causes the electric shock sample pain in bicker region on the right side of place between the eyebrows right face, feed, brushing teeth also can Provocative pain, pain continued for more than ten seconds every time, acutely, it is difficult to stand.Continue to take carbamazepine invalid after change and take Chinese medicine preparation of the present invention.
In embodiment 4, gained granules of sugar agent boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, and one time 2 bag, 10 days is a course for the treatment of, after using 15 days, and sense that corners of the mouth anacidity in right side is swollen, can normally take food；After taking 30 days, symptom is wholly absent, and follows up a case by regular visits to 3 months, does not recur.
Embodiment 5 treats prosopalgic Chinese medicine preparation, takes off the primary raw material stating weight proportion and is prepared from (every part takes 30g): the Radix Astragali 8 parts, Rhizoma Acori Graminei 13 parts, 5 parts of Rhizoma Gastrodiae, Scorpio 3 parts, Bombyx Batryticatus 3 parts, Fructus Bruceae 15 parts, Herba Schizonepetae 18 parts, Rhizoma Paridis tetraphyllae 10 parts, Tupistra chinensis Bak. 12 parts.
The preparation method of the prosopalgic sugar free granule of above-mentioned treatment, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 130 mesh sieves；
2. Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 2.5 hours in 45 DEG C of water；
3. by the Scorpio after soaking, Bombyx Batryticatus boiling 2 times, adding 7 times amount water every time, each decoct 4.5 hours, be then combined with medicinal liquid, filter, filtrate mixes with step 1. middle gained medicated powder, is then concentrated into relative density and is about 1.25(60 DEG C) clear paste, be cooled to room temperature；
4. adding ethanol in step 3. gained clear paste makes alcohol content reach 60%, stands, takes supernatant concentration and become relative density 1.7(60 DEG C) thick paste, add dextrin, steviosin appropriate, mixing, spray drying, with a sieve, No. five screen grains, sugar-free granule can be obtained.
Treatment trigeminal neuralgia is had definite curative effect for the Chinese medicine preparation verifying the present invention by experimental example, has randomly drawed 200 and has suffered from prosopalgic diabetics, and the mean age is 55 years old, minimum 40 years old, maximum 70 years old.It is divided into administration group and matched group according to the state of an illness and pathology, often organizes each 100 people, it is ensured that administration group and matched group situation are basically identical.
Administration group uses the embodiment of the present invention 5 gained sugar free granule every day, and for making sugar free granule of the present invention reach optimum therapeuticing effect, in embodiment 5, gained sugar free granule boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, and a 1-2 bag, 10 days is a course for the treatment of.Matched group uses the prosopalgic medicine of other treatment (medicine as prosopalgic in the conventional therapy such as carbamazepine, phenytoin Sodium).Criterion: 1. recovery from illness: pain is wholly absent, diet and sleep are all normal；2. effective: pain substantially alleviates, diet and sleep normal；3. effective: pain relief, attack times significantly reduces before relatively treating, and diet and sleep all have and to a certain degree improve；4. invalid: after 1 course for the treatment of of above-mentioned treatment, pain degree and attack times all without improving, even increase the weight of.
Observe 30 days time limits, observed once every 5 days, record the number that disease is substantially alleviated；
Analyze: can be seen that from observed result, Chinese medicine preparation of the present invention can make panic attacks frequent, diet and the affected patient that sleeps, and alleviates its pain taking medicine in the shorter time, can effectively alleviate and cure the pain symptom of patient, and patient blood glucose will not be caused to raise.
Matched group takes the prosopalgic medicine of other treatment and administration group takes Chinese medicine preparation Comparison of therapeutic of the present invention, and result is as shown in table 1:
Table 1
Analyzing: from table 1 it follows that take and use Chinese medicine preparation effective percentage of the present invention up to 98%, cure rate is up to 95%, and uses first time obvious effective rate to reach 90%, and effect is substantially good than taking the prosopalgic medicine of other treatment.
Administration group (sugar free granule of the present invention) and matched group all can reach the purpose of fast pain relief in 30 days of observation period, but there will be the untoward reaction that the side effect such as sleepy, dizziness, movement disorder sample balance dysfunction, erythra, Nausea and vomiting cause in matched group after part patient on medication.Chinese medicine preparation of the present invention adopts Chinese medicinal material simple and easy to get as raw material, has determined curative effect, instant effect, cure rate is high, the feature that has no side effect, it is possible to effectively treat trigeminal neuralgia.

Claims (1)

1. treat prosopalgic Chinese medicine preparation, it is characterized in that, take the raw material of following portions by weight: the Radix Astragali 8 parts, Rhizoma Acori Graminei 13 parts, 5 parts of Rhizoma Gastrodiae, Scorpio 3 parts, Bombyx Batryticatus 3 parts, Fructus Bruceae 15 parts, Herba Schizonepetae 18 parts, Rhizoma Paridis tetraphyllae 10 parts, Tupistra chinensis Bak. 12 parts；Preparation method step is as follows:
(1) Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 130 mesh sieves；
(2) Scorpio, Bombyx Batryticatus are removed impurity, clean, soak 2.5 hours in 45 DEG C of water；
(3) by the Scorpio after immersion, Bombyx Batryticatus boiling 2 times, adding 7 times amount water every time, each pan-fried 4.5 hours, be then combined with medicinal liquid, filter, filtrate mixes with gained medicated powder in step (1), is then concentrated into the clear paste that relative density is 1.25, is cooled to room temperature；
(4) adding ethanol in step (3) gained clear paste makes alcohol content reach 60%, stands, takes supernatant concentration and become the thick paste of relative density 1.7, add dextrin, steviosin in right amount, mixing, spray drying, with a sieve, No. five screening grains, prosopalgic Chinese medicine preparation sugar-free granule must be treated.
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