CN105395905A - Medicine for treating prosopalgia - Google Patents
Medicine for treating prosopalgia Download PDFInfo
- Publication number
- CN105395905A CN105395905A CN201510872116.9A CN201510872116A CN105395905A CN 105395905 A CN105395905 A CN 105395905A CN 201510872116 A CN201510872116 A CN 201510872116A CN 105395905 A CN105395905 A CN 105395905A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- scorpio
- water
- bombyx batryticatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 65
- 229940079593 drug Drugs 0.000 title abstract description 4
- 241000522620 Scorpio Species 0.000 claims abstract description 31
- 239000009490 scorpio Substances 0.000 claims abstract description 30
- 241000255791 Bombyx Species 0.000 claims abstract description 29
- 241001621801 Rohdea chinensis Species 0.000 claims abstract description 22
- 239000009636 Huang Qi Substances 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- 239000008187 granular material Substances 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- 239000009969 fructus bruceae Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 239000004375 Dextrin Substances 0.000 claims description 7
- 229920001353 Dextrin Polymers 0.000 claims description 7
- 235000019425 dextrin Nutrition 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- -1 filter Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 5
- 239000007779 soft material Substances 0.000 claims description 5
- 229960004793 sucrose Drugs 0.000 claims description 5
- 206010013786 Dry skin Diseases 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 20
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 244000205574 Acorus calamus Species 0.000 abstract 1
- 235000006480 Acorus calamus Nutrition 0.000 abstract 1
- 241001533159 Brucea javanica Species 0.000 abstract 1
- 235000010889 Rhus javanica Nutrition 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 34
- 230000036407 pain Effects 0.000 description 34
- 206010044652 trigeminal neuralgia Diseases 0.000 description 22
- 210000004185 liver Anatomy 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 6
- 239000002674 ointment Substances 0.000 description 6
- 231100000614 poison Toxicity 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 5
- 229960000623 carbamazepine Drugs 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 230000036461 convulsion Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 4
- 231100000869 headache Toxicity 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 230000007958 sleep Effects 0.000 description 4
- 238000002791 soaking Methods 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- 208000025747 Rheumatic disease Diseases 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 208000000260 Warts Diseases 0.000 description 3
- 238000013475 authorization Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 210000003026 hypopharynx Anatomy 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 230000007096 poisonous effect Effects 0.000 description 3
- 230000000552 rheumatic effect Effects 0.000 description 3
- 201000005404 rubella Diseases 0.000 description 3
- 201000010153 skin papilloma Diseases 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010019468 Hemiplegia Diseases 0.000 description 2
- 241000234280 Liliaceae Species 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 206010033664 Panic attack Diseases 0.000 description 2
- 206010039424 Salivary hypersecretion Diseases 0.000 description 2
- 208000008630 Sialorrhea Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 206010041349 Somnolence Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 2
- 206010043376 Tetanus Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 208000019906 panic disease Diseases 0.000 description 2
- 230000001314 paroxysmal effect Effects 0.000 description 2
- 229960002790 phenytoin sodium Drugs 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- FJPYVLNWWICYDW-UHFFFAOYSA-M sodium;5,5-diphenylimidazolidin-1-ide-2,4-dione Chemical compound [Na+].O=C1[N-]C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 FJPYVLNWWICYDW-UHFFFAOYSA-M 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 206010042772 syncope Diseases 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000209495 Acorus Species 0.000 description 1
- 241000209524 Araceae Species 0.000 description 1
- 206010004542 Bezoar Diseases 0.000 description 1
- 241000143476 Bidens Species 0.000 description 1
- 241000158621 Brucea Species 0.000 description 1
- 241000239311 Buthus Species 0.000 description 1
- 241001517488 Clavus Species 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 241000218176 Corydalis Species 0.000 description 1
- 208000019736 Cranial nerve disease Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010052140 Eye pruritus Diseases 0.000 description 1
- 206010016059 Facial pain Diseases 0.000 description 1
- 206010063006 Facial spasm Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- LZKVXMYVBSNXER-YZPKDWIXSA-N Glaucarubin Chemical compound O[C@@H]([C@]1(C)[C@@H]23)[C@@H](O)C=C(C)[C@@H]1C[C@@H]1[C@@]43CO[C@@]2(O)[C@H](O)[C@H](C)[C@@H]4[C@@H](OC(=O)[C@@](C)(O)CC)C(=O)O1 LZKVXMYVBSNXER-YZPKDWIXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000283956 Manis Species 0.000 description 1
- 241001480581 Marasmius Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000156622 Paris bashanensis Species 0.000 description 1
- 241001522129 Pinellia Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000951376 Schizonepeta tenuifolia Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 208000024756 faint Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000002418 meninge Anatomy 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Insects & Arthropods (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicine for treating prosopalgia. The medicine is mainly prepared from the following raw materials in parts by weight: 6-9 parts of radix astragali, 10-15 parts of drug sweetflag rhizome, 3-6 parts of rhizoma gastrodiae, 1-5 parts of scorpio, 1-5 parts of bombyx batryticatus, 10-20 parts of brucea javanica fruit, 10-25 parts of spica schizonepetae, 5-15 parts of rhizome of fourleaf paris and 8-16 parts of rhizome of tupistra chinensis baker. The medicine disclosed by the invention has the characteristics of being concrete in curative effect, rapid to take effect, high in cure rate and free from toxic and side effects, and the medicine is capable of effectively treating the prosopalgia.
Description
divisional application, original applying number 2014101570801, applying date 2014.04.19, title one treats prosopalgic Chinese medicine preparation and preparation method thereof.
Technical field
The present invention relates to one and treated prosopalgic Chinese medicine preparation and preparation method thereof, belonged to traditional Chinese medicine field, be mainly used in treating trigeminal neuralgia.
Background technology
Trigeminal neuralgia is modal cranial nerve diseases, be also sometimes referred to as " face pain ", be a kind of violent neuralgia of paroxysmal of recurrent exerbation in facial nervi trigeminus areal area, trigeminal neuralgia is one of neurosurgery commonly encountered diseases, is also one of internationally recognized difficult miscellaneous diseases.The morbidity in 40 years old of most trigeminal neuralgias, multiplely be born in middle-aged and elderly people, women is especially many, its R)L of falling ill, the feature of this disease is: in Head And Face nervi trigeminus distributed areas, morbidity is rapid to be sent out, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking, therefore affected nerves of patients with trigeminal neuralgia often dare not wipe face, feed, and even saliva also dare not be swallowed, thus affects normal live and work.There is this pain of person for " the first under heaven pain ".
Trigeminal neuralgia can be divided into constitutional (symptomatic) trigeminal neuralgia and the large class of secondary trigeminal neuralgia two, and wherein primary trigeminal neuralgia is more common.Primary trigeminal neuralgia: refer to the trigeminal neuralgia that can not find the definite cause of disease.May be owing to supplying the sclerosis of blood vessel and pressuring nerve causes, also may be to cause compressing to cause pain because the bone hole that meninges thickens, nerve passes through is narrow.Secondary trigeminal neuralgia: refer to the trigeminal neuralgia because oncothlipsis, inflammation, vascular malformation cause.This kind of is different from idiopathic feature, and pain often in persistence, and can find the pathological changes sign of nervi trigeminus proximity structure.
In the invention of the prosopalgic Chinese medicine preparation of existing treatment, Authorization Notice No. CN102847125B(application number 201210362059.6) disclose one and treat prosopalgic medicine and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Radix Rehmanniae, Rhizoma Cimicifugae, Radix Ginseng, Herba Menthae, Rhizoma Arisaematis, Rhizoma Gastrodiae, Rhizoma Alismatis, Rhizoma Zingiberis Recens, the Rhizoma Anemarrhenae, the Rhizoma Pinelliaes.Authorization Notice No. CN102961450B(application number 201210539444.3) disclose one and treat prosopalgic Chinese medicine composition, this Chinese medicine composition is by Caulis et folium stauntoniae, Marasmius equicrinis Muell., Folium Sennae, Radix Stephaniae Cepharanthae, Rhizoma Chuanxiong, Rhizoma Corydalis, Radix Cynanchi Auriculati, Radix Dipsaci, Squama Manis, Nidus Vespae, Radix Glycyrrhizae is made.Authorization Notice No. CN102357238B(application number 201110328707.1) disclose one and treat prosopalgic Chinese medicine composition, be made up of the raw material of following weight: Fructus Evodiae 8-10 gram, Radix Ginseng 9-15 gram, Rhizoma Zingiberis Recens 9-15 gram, Fructus Jujubae 9-15 gram, Radix Asparagi 4-8 gram, Radix Ophiopogonis 4-8 gram, Rhizoma Cimicifugae 1-5 gram, Bidens paruiflora Willd. 4-8 gram, Pericarpium Papaveris 4-8 gram, Semen Persicae mud 1-3 gram, Flos Carthami 1-3 gram, Semen Pruni Salicinae 8-1 gram, Rhizoma Gastrodiae 4-6 gram.
Summary of the invention
For prosopalgic present situation, one is the object of the present invention is to provide to treat prosopalgic Chinese medicine preparation and preparation method thereof, the present invention develops in conjunction with clinical experience on the basis that traditional differential diagnosis in tcm treats, have the advantages that determined curative effect, instant effect, cure rate are high, have no side effect, effectively can treat trigeminal neuralgia.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from: Radix Astragali 6-9 part, Rhizoma Acori Graminei 10-15 part, Rhizoma Gastrodiae 3-6 part, Scorpio 1-5 part, Bombyx Batryticatus 1-5 part, Fructus Bruceae 10-20 part, Herba Schizonepetae 10-25 part, Rhizoma Paridis tetraphyllae 5-15 part, Tupistra chinensis Bak. 8-16 part.
The prosopalgic Chinese medicine preparation of above-mentioned treatment, preferred scheme, take off the primary raw material stating weight proportion to be prepared from: Radix Astragali 7-8 part, Rhizoma Acori Graminei 11-14 part, Rhizoma Gastrodiae 4-5 part, Scorpio 2-4 part, Bombyx Batryticatus 2-4 part, Fructus Bruceae 13-17 part, Herba Schizonepetae 15-20 part, Rhizoma Paridis tetraphyllae 9-11 part, Tupistra chinensis Bak. 10-14 part.
The above treats prosopalgic Chinese medicine preparation, better preferred scheme, takes off the primary raw material stating weight proportion and is prepared from: the Radix Astragali 8 parts, Rhizoma Acori Graminei 13 parts, 5 parts, Rhizoma Gastrodiae, Scorpio 3 parts, Bombyx Batryticatus 3 parts, Fructus Bruceae 15 parts, Herba Schizonepetae 18 parts, Rhizoma Paridis tetraphyllae 10 parts, Tupistra chinensis Bak. 12 parts.
According to the prosopalgic Chinese medicine preparation of arbitrary described treatment above, be prepared into pharmaceutically acceptable unguentum, granules of sugar agent or sugar free granule.
According to the prosopalgic Chinese medicine preparation of described treatment above, the preparation method of unguentum, step is as follows:
1. the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverize, cross 100-160 mesh sieve (preferably 130 mesh sieves);
2. by Scorpio, Bombyx Batryticatus removing impurity, clean, in 30-60 DEG C of water, soak 1-4 hour;
3. the Scorpio after immersion, Bombyx Batryticatus are decocted with water 2 times, add 4-10 times of water gaging (preferred amount of water to 7 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then medicinal liquid is merged, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.05-1.5(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
According to preparation method recited above, preferred scheme is, 2. step uses the water (preferably 45 DEG C) of 40-50 DEG C.
According to preparation method recited above, preferred scheme is, 2. step soaks 2-3 hour (preferably 2.5 hours).
According to preparation method recited above, preferred scheme is, 3. step is concentrated into the preferred relative density to 1.25 of relative density 1.1-1.4().
According to the prosopalgic Chinese medicine preparation of described treatment above, the preparation method of granules of sugar agent, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 100-160 mesh sieve (preferably 130 mesh sieves);
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak in 30-60 DEG C of (preferably 45 DEG C) water 1-4 hour (preferably 2.5 hours);
3. the Scorpio after immersion, Bombyx Batryticatus are decocted with water 2 times, add 4-10 times of water gaging (preferred amount of water 7 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then medicinal liquid is merged, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, getting supernatant concentration to relative density is 1.2-1.8(60 DEG C) thick paste of (preferred relative density to 1.5), add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 10-24 mesh sieve granule (preferably 17 mesh sieves), wet granular is dry in 40-80 DEG C (preferably 60 DEG C), and dry granule crosses 17 mesh sieve granulate, screens out fine powder after No. five, subpackage, check, packaging, get product medicament.
According to the prosopalgic Chinese medicine preparation of described treatment above, the preparation method of sugar free granule, step is as follows:
by the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. is cleaned, and pulverizes, and crosses 100-160 mesh sieve (preferably 130 mesh sieves);
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak in 30-60 DEG C of (preferably 45 DEG C) water 1-4 hour (preferably 2.5 hours);
3. the Scorpio after immersion, Bombyx Batryticatus are decocted with water 2 times, add 4-10 times of water gaging (preferred amount of water to 7 times) at every turn, respectively decoct 3-5 hour (preferably 4 hours), then medicinal liquid is merged, filter, filtrate and step 1. in gained medicated powder mix, be then concentrated into relative density and be about 1.05-1.5(60 DEG C) clear paste of (preferred relative density to 1.25), be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leaves standstill, gets supernatant concentration and become the preferred relative density to 1.7 of relative density 1.6-1.8() thick paste of (60 DEG C), add dextrin, steviosin is appropriate, mixing, spraying dry, with a sieve, No. five screening grains, obtain sugar-free granule.
Treat prosopalgic Chinese medicine preparation, the pharmacological effect of each raw material is respectively:
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Effect: benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Cure mainly the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back.
Rhizoma Acori Graminei: be the rhizome of Acorus of Araceae phytobezoar Rhizoma Acori Graminei.The property of medicine: pungent, bitter, tepor, GUIXIN, liver, spleen channel.Effect: eliminate phlegm for resuscitation, removing dampness to restore normal function of the stomach, mind calming benefit will.Cure mainly calentura coma, syncope due to accumulation of phlegm, forgetful, insomnia, tinnitus, deaf, fasting dysentery, rheumatic arthralgia.
Rhizoma Gastrodiae: sweet, pungent is flat.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.
Scorpio: be the entirety of Buthidae Buthus animal Scorpio.The property of medicine: salty, pungent, flat, poisonous.Return Liver Channel.Effect: relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Attending pediatric epilepsy, epilepsy, stroke hemiplegia, mouth askew, polarized headache, rheumatism obstinate arlhralgia, tetanus, scrofula phlegm nucleus, rubella swollen poison.
Bombyx Batryticatus: the larva belonging to animal bombyx mori for Bombycidae silkworm infects muscardine and ossified Scorpio.The property of medicine: pungent, salty, flat.Return liver, lung, stomach warp.Effect: expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat.Cure mainly infantile convulsion, twitch, middle wind-eye mouth is crooked, migraine and general headache, laryngopharynx swelling and pain, scrofula, mumps, rubella, sore.
Fructus Bruceae: be the fruit of Simarubaceae brucea plant Fructus Bruceae.The property of medicine: bitter, cold.Mild toxicity.Return large intestine, Liver Channel.Effect: heat clearing away, removing toxic substances, parasite killing, preventing the attack (or recurrence) of malaria, erosion wart.Cure mainly toxic-heat and blood stasis, cold-dysentery, chronic dysentery with frequent relapse, malaria, hemorrhoid, carbuncle, pudendal pruritus, leucorrhea, wart wart, clavus, venom.
Herba Schizonepetae: be the spica of Labiatae Schizonepeta tenuifolia platymiscium Herba Schizonepetae and many lobed leaf Herba Schizonepetae.The property of medicine: pungent, micro-hardship, tepor.Return lung, Liver Channel.Effect: dispel the wind, induces sweat, rash, hemostasis.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, skin ulcer scabies, epistaxis, spit blood, have blood in stool, metrorrhagia, puerperal blood faints.
Rhizoma Paridis tetraphyllae: be the rhizome of Liliaceae paris plant Paris bashanensis Wang et Tang.The property of medicine: bitter, pungent, temperature.Effect: expelling cold and dampness, removing obstruction in the collateral to relieve pain, hemostasia and promoting granulation.Cure mainly chronic arthralgia caused by cold-damp, chills and pain of the waist and kness, traumatic hemorrhage.
Tupistra chinensis Bak.: be the rhizome of Liliaceae Tupistra plant Tupistra chinensis Bak. and sword-like leave Tupistra chinensis Bak..The property of medicine: bitter, acrid, cold.Poisonous.Effect: heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain.Cure mainly diphtheria, laryngopharynx swelling and pain, rheumatic arthralgia, traumatic injury, stomachache, carbuncle sore tumefacting virus, poisonous snake, lyssodexis.
The invention provides Chinese medicine preparation scientific formula, preparation method is simple, products obtained therefrom taking convenience, and effectively can treat trigeminal neuralgia.In addition, excellent results of the present invention also shows:
1,medicine source is easy to get, cheap, and medical expense is low;
2,the property of medicine is gentle, dosage form taking convenience, and patient is acceptant;
3,use medical material for Chinese medicine material, toxicity is little, can not cause any actual bodily harm to patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part) Radix Astragali 6 parts, Rhizoma Acori Graminei 10 parts, 3 parts, Rhizoma Gastrodiae, Scorpio 1 part, Bombyx Batryticatus 1 part, Fructus Bruceae 10 parts, Herba Schizonepetae 10 parts, Rhizoma Paridis tetraphyllae 5 parts, Tupistra chinensis Bak. 8 parts.
The preparation method of the prosopalgic granules of sugar agent of above-mentioned treatment, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 100 mesh sieves;
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak 1 hour in 30 DEG C of water;
3. Scorpio, Bombyx Batryticatus after soaking are decocted with water 2 times, add 4 times of water gagings at every turn, respectively decoct 3 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.05(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, getting supernatant concentration to relative density is 1.2(60 DEG C) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 10 mesh sieve granules, wet granular is in 40 DEG C of dryings, and dry granule is crossed 17 mesh sieve granulate and to be got product medicament.
typical case onezhao XX, man, 45 years old.Tell right side occiput pain 30 years, right side face electric shock sample pain 6 years, pain position is mainly on the right side of place between the eyebrows.Face and right side bicker sharp ache on the right side of the bridge of the nose, each lasting ten seconds, outbreak was frequent.Shed tears and sialorrhea with right side eye during panic attacks, facial spasm, conjunctival congestion.There is insomnia during serious symptom, cannot take food.Confirm as trigeminal neuralgia after diagnosing.
Embodiment 1 gained granules of sugar agent boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, and one time 1 bag, 10 days is a course for the treatment of, uses 15 days, and on the right side of the bridge of the nose, facial and right side bicker pain takes a turn for the better to some extent.Use 30 days pain to disappear, follow up a case by regular visits to and no longer recur.
embodiment 2treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from (getting 5g for every part): the Radix Astragali 9 parts, Rhizoma Acori Graminei 15 parts, 6 parts, Rhizoma Gastrodiae, Scorpio 5 parts, Bombyx Batryticatus 5 parts, Fructus Bruceae 20 parts, Herba Schizonepetae 25 parts, Rhizoma Paridis tetraphyllae 15 parts, Tupistra chinensis Bak. 16 parts.
The preparation method of the prosopalgic granules of sugar agent of above-mentioned treatment, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 160 mesh sieves;
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak 4 hours in 60 DEG C of water;
3. Scorpio, Bombyx Batryticatus after soaking are decocted with water 2 times, add 10 times of water gagings at every turn, respectively decoct 5 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.5(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, getting supernatant concentration to relative density is 1.8(60 DEG C) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 24 mesh sieve granules, wet granular is in 80 DEG C of dryings, and dry granule is crossed 17 mesh sieve granulate and to be got product medicament.
typical case twowu XX, female, 45 years old, worker.In May, 2013 goes to a doctor.Suffer from primary trigeminal neuralgia more than a year.On the right side of oral cavity, pain acutely taken out by the gingiva position sample that often occurs lancinating, and lasts 1-2 minute at every turn.Often take phenytoin sodium tablet and Carbamazepine Tablets, maintain not pain reluctantly.Recent feels pain is day by day violent, and occurs the side effect such as drowsiness, dizzy after taking medicine, and then cuts out former medicine, uses Chinese medicine preparation of the present invention instead.
Embodiment 2 gained granules of sugar agent boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, and one time 1 bag, within 10 days, be a course for the treatment of, use 20 days, feels pain alleviates to some extent, does not substantially affect normal life and work.Take 40 days, sensation primary trigeminal neuralgia is fully recovered, and no longer falls ill.Occur without malaise symptoms between the operating period.Follow up a case by regular visits to 2 years, do not recur.
embodiment 3treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): the Radix Astragali 7 parts, Rhizoma Acori Graminei 11 parts, 4 parts, Rhizoma Gastrodiae, Scorpio 2 parts, Bombyx Batryticatus 2 parts, Fructus Bruceae 13 parts, Herba Schizonepetae 15 parts, Rhizoma Paridis tetraphyllae 9 parts, Tupistra chinensis Bak. 10 parts.
The preparation method of the prosopalgic unguentum of above-mentioned treatment, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 130 mesh sieves;
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak 2.5 hours in 45 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus are decocted with water 2 times, add 7 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, then be concentrated into relative density and be about 1.25(60 DEG C) clear paste, be cooled to room temperature, sterile packaged obtains unguentum.
typical case threeyellow XX, man, 52 years old, peasant.On the right side of main cause, the ictal pain of facial area is gone to a doctor for 1 year, once oral carbamazepine 1, three times on the one, symptom once alleviated, but increased the weight of once again subsequently, and nearly two weeks carrys out patient and occurs having a dizzy spell, the lumbago soreness of waist, emotion is irritated, and attack times is more frequent, firmly rubs face so that local skin is coarse, thicken, milphae, conjunctival congestion, shed tears and sialorrhea with palm.Medicament of the present invention is taken after hospital is diagnosed as trigeminal neuralgia.
Embodiment 3 gained unguentum boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, a 50ml, within 10 days, is a course for the treatment of, uses after 30 days, without obvious pain, seldom occur lumbago soreness of waist symptom.Take 45 days, cure, follow up a case by regular visits to without recurrence.
embodiment 4treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): the Radix Astragali 8 parts, Rhizoma Acori Graminei 14 parts, 5 parts, Rhizoma Gastrodiae, Scorpio 4 parts, Bombyx Batryticatus 4 parts, Fructus Bruceae 17 parts, Herba Schizonepetae 20 parts, Rhizoma Paridis tetraphyllae 11 parts, Tupistra chinensis Bak. 14 parts.
The preparation method of the prosopalgic granules of sugar agent of above-mentioned treatment, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 130 mesh sieves;
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak 2.5 hours in 45 DEG C of water;
3. Scorpio, Bombyx Batryticatus after soaking are decocted with water 2 times, add 7 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.25(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leave standstill, getting supernatant concentration to relative density is 1.5(60 DEG C) thick paste, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 17 mesh sieve granules, wet granular is in 50 DEG C of dryings, and dry granule is crossed 17 mesh sieve granulate and to be got product medicament.
typical case fourpoplar XX, female, 63 years old, peasant.There are trigeminal neuralgia about 4 years medical histories, maintain by taking Western medicine carbamazepine at ordinary times, within nearest 1 year, there is the swollen sense of right side bicker acid every a few days, how by day, can not touch, irriate then causes the electric shock sample pain in place between the eyebrows-right face-bicker region, right side, feed, brushing teeth also can Provocative pain, pain continued for more than ten seconds at every turn, acutely, was difficult to stand.Continue to take carbamazepine invalid after change and take Chinese medicine preparation of the present invention.
In embodiment 4, gained granules of sugar agent boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, one time 2 bag, and within 10 days, be a course for the treatment of, use after 15 days, the swollen sense of anacidity of the right side corners of the mouth, can normally take food; After taking 30 days, symptom disappears completely, follows up a case by regular visits to 3 months, does not recur.
embodiment 5treat prosopalgic Chinese medicine preparation, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): the Radix Astragali 8 parts, Rhizoma Acori Graminei 13 parts, 5 parts, Rhizoma Gastrodiae, Scorpio 3 parts, Bombyx Batryticatus 3 parts, Fructus Bruceae 15 parts, Herba Schizonepetae 18 parts, Rhizoma Paridis tetraphyllae 10 parts, Tupistra chinensis Bak. 12 parts.
The preparation method of the prosopalgic sugar free granule of above-mentioned treatment, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 130 mesh sieves;
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak 2.5 hours in 45 DEG C of water;
3. Scorpio, Bombyx Batryticatus after soaking are decocted with water 2 times, add 7 times of water gagings at every turn, respectively decoct 4.5 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into relative density and are about 1.25(60 DEG C) clear paste, be cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, leaves standstill, gets supernatant concentration and become relative density 1.7(60 DEG C) thick paste, add dextrin, steviosin be appropriate, mixing, spraying dry, with a sieve, No. five screen grains, sugar-free granule can be obtained.
experimental examplein order to verify that Chinese medicine preparation of the present invention has definite curative effect to treatment trigeminal neuralgia, randomly drawed 200 and suffered from prosopalgic diabetics, the mean age is 55 years old, minimum 40 years old, maximum 70 years old.Be divided into administration group and matched group according to the state of an illness and pathology, often organize each 100 people, guarantee administration group and matched group situation basically identical.
Administration group uses the embodiment of the present invention 5 gained sugar free granule every day, and for making sugar free granule of the present invention reach optimum therapeuticing effect, in embodiment 5, gained sugar free granule boiled water is taken after mixing it with water, and every day is early, middle and late respectively takes 1 time, and a 1-2 bag 10 days is a course for the treatment of.Matched group uses the prosopalgic medicine of other treatment (medicine as prosopalgic in the conventional therapy such as carbamazepine, phenytoin Sodium).Criterion: 1. fully recover: pain disappears completely, diet and sleep all normal; 2. effective: pain obviously alleviates, diet and sleep normal; 3. effective: pain relief, attack times obviously reduces before comparatively treating, and diet and sleep all have and to a certain degree improve; 4. invalid: after 1 course for the treatment of of above-mentioned treatment, pain degree and attack times all without improvement, even increase the weight of.
Observe 30 days time limits, observed once every 5 days, record the number that disease is obviously alleviated;
Analyze: as can be seen from observed result, Chinese medicine preparation of the present invention can make panic attacks frequent, diet and the affected patient that sleeps, and alleviates its pain taking medicine in the shorter time, effectively can alleviate and cure the pain symptom of patient, and patient blood glucose can not be caused to raise.
Matched group takes the prosopalgic medicine of other treatment and administration group takes Chinese medicine preparation Comparison of therapeutic of the present invention, and result is as shown in table 1:
Table 1
Analyze: as can be seen from Table 1, take and use Chinese medicine preparation effective percentage of the present invention up to 98%, cure rate up to 95%, and uses obvious effective rate for the first time to reach 90%, and successful is better than taking the prosopalgic medicine of other treatment.
Administration group (sugar free granule of the present invention) and matched group all can reach the object of fast pain relief in 30 days of the observation period, but there will be the untoward reaction that sleepy, dizzy, the side effect such as movement disorder sample balance dysfunction, erythra, Nausea and vomiting causes in matched group after part patient on medication.Chinese medicine preparation of the present invention adopts Chinese medicinal material simple and easy to get as raw material, has the advantages that determined curative effect, instant effect, cure rate are high, have no side effect, effectively can treat trigeminal neuralgia.
Claims (2)
1. treat prosopalgic Chinese medicine preparation, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: the Radix Astragali 8 parts, Rhizoma Acori Graminei 14 parts, 5 parts, Rhizoma Gastrodiae, Scorpio 4 parts, Bombyx Batryticatus 4 parts, Fructus Bruceae 17 parts, Herba Schizonepetae 20 parts, Rhizoma Paridis tetraphyllae 11 parts, Tupistra chinensis Bak. 14 parts.
2. treat the preparation method of prosopalgic Chinese medicine preparation granules of sugar agent, it is characterized in that, step is as follows:
the Radix Astragali, Rhizoma Acori Graminei, Rhizoma Gastrodiae, Fructus Bruceae, Herba Schizonepetae, Rhizoma Paridis tetraphyllae, Tupistra chinensis Bak. are cleaned, pulverizes, cross 130 mesh sieves;
by Scorpio, Bombyx Batryticatus removing impurity, clean, soak 2.5 hours in 45 DEG C of water;
3. the Scorpio after immersion, Bombyx Batryticatus are decocted with water 2 times, add 7 times of water gagings at every turn, respectively decoct 4 hours, then merge medicinal liquid, filter, filtrate and step 1. middle gained medicated powder mix, and are then concentrated into the clear paste that relative density is about 1.25, are cooled to room temperature;
in step 3. gained clear paste, add ethanol makes alcohol content reach 60%, and leave standstill, getting supernatant concentration to relative density is the thick paste of 1.5, add cane sugar powder, dextrin and ethanol in proper amount soft material, cross 17 mesh sieve granules, wet granular is in 50 DEG C of dryings, and dry granule is crossed 17 mesh sieve granulate and to be got product medicament.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410157080.1A CN103908583B (en) | 2014-04-19 | 2014-04-19 | One treats prosopalgic Chinese medicine preparation and preparation method thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410157080.1A Division CN103908583B (en) | 2014-04-19 | 2014-04-19 | One treats prosopalgic Chinese medicine preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105395905A true CN105395905A (en) | 2016-03-16 |
Family
ID=51034787
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510872254.7A Withdrawn CN105395906A (en) | 2014-04-19 | 2014-04-19 | Pharmaceutical preparation for treating prosopalgia |
| CN201510871987.9A Withdrawn CN105395903A (en) | 2014-04-19 | 2014-04-19 | Preparation method of traditional Chinese medicinal preparation sugar-containing granule for treating prosopalgia |
| CN201410157080.1A Expired - Fee Related CN103908583B (en) | 2014-04-19 | 2014-04-19 | One treats prosopalgic Chinese medicine preparation and preparation method thereof |
| CN201510872106.5A Withdrawn CN105395904A (en) | 2014-04-19 | 2014-04-19 | Preparation method of traditional Chinese medicinal preparation ointment for treating prosopalgia |
| CN201510872116.9A Withdrawn CN105395905A (en) | 2014-04-19 | 2014-04-19 | Medicine for treating prosopalgia |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510872254.7A Withdrawn CN105395906A (en) | 2014-04-19 | 2014-04-19 | Pharmaceutical preparation for treating prosopalgia |
| CN201510871987.9A Withdrawn CN105395903A (en) | 2014-04-19 | 2014-04-19 | Preparation method of traditional Chinese medicinal preparation sugar-containing granule for treating prosopalgia |
| CN201410157080.1A Expired - Fee Related CN103908583B (en) | 2014-04-19 | 2014-04-19 | One treats prosopalgic Chinese medicine preparation and preparation method thereof |
| CN201510872106.5A Withdrawn CN105395904A (en) | 2014-04-19 | 2014-04-19 | Preparation method of traditional Chinese medicinal preparation ointment for treating prosopalgia |
Country Status (1)
| Country | Link |
|---|---|
| CN (5) | CN105395906A (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1046093C (en) * | 1994-04-05 | 1999-11-03 | 戚嘉和 | Traditional Chinese medicinal prepn. for treating trifacial neuralgia |
| CN1272057C (en) * | 2003-11-24 | 2006-08-30 | 游国峰 | Chinese traditional medicine for treating facial paralysis, facial spasm and trifacial neuralgia |
| CN1239193C (en) * | 2004-01-06 | 2006-02-01 | 张福成 | Chinese medicine for treating trigeminal neuralgia and its preparation method |
| CN102988777A (en) * | 2012-11-13 | 2013-03-27 | 于良卫 | Facial paralysis capsule |
-
2014
- 2014-04-19 CN CN201510872254.7A patent/CN105395906A/en not_active Withdrawn
- 2014-04-19 CN CN201510871987.9A patent/CN105395903A/en not_active Withdrawn
- 2014-04-19 CN CN201410157080.1A patent/CN103908583B/en not_active Expired - Fee Related
- 2014-04-19 CN CN201510872106.5A patent/CN105395904A/en not_active Withdrawn
- 2014-04-19 CN CN201510872116.9A patent/CN105395905A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 马玉科等: "消痛煎治疗老年三叉神经痛62例", 《现代中医药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105395906A (en) | 2016-03-16 |
| CN103908583A (en) | 2014-07-09 |
| CN105395903A (en) | 2016-03-16 |
| CN105395904A (en) | 2016-03-16 |
| CN103908583B (en) | 2016-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103610885B (en) | Traditional Chinese medicine preparation for treating rash | |
| CN105663656A (en) | Pharmaceutical composition for treating sleep disorders and preparing method thereof | |
| CN103908583B (en) | One treats prosopalgic Chinese medicine preparation and preparation method thereof | |
| CN105521332A (en) | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof | |
| CN103933374A (en) | Formula of traditional Chinese medicine for treating migraine and preparation method thereof | |
| CN103721028B (en) | One treats anginal medicine and preparation method | |
| CN105663959A (en) | Traditional Chinese medicine preparation for nursing patient suffering from toothache and preparation method | |
| CN104826068A (en) | Medicine for expelling wind and eliminating dampness and preparation method of medicine | |
| CN104523850A (en) | Medicine composition for treating rhinitis and nasosinusitis | |
| CN103893509B (en) | A kind of medicine for the treatment of of allergic rhinitis and preparation method | |
| CN104162038A (en) | Traditional Chinese medicine composition for treating neonatal seizures and preparation method thereof | |
| CN104258032A (en) | Traditional Chinese medicine composition for treating stomach cancer | |
| CN102631568B (en) | Pills for treating cervical spondylosis | |
| CN105381249A (en) | Traditional Chinese medicine combination for treating lumbar muscle strain and preparation method and application thereof | |
| CN104906521A (en) | Traditional Chinese medicine preparation for treating tetanus | |
| CN105194243A (en) | Capsule for treating chronic amygdalitis due to invasion of wind evil and preparation method of capsule | |
| CN104984063A (en) | Preparation for treating tetanus and preparation method of preparation | |
| CN104758665A (en) | Nursing medicine for treating post-stroke depression | |
| CN105031457A (en) | Eye drops for treating conjunctivitis | |
| CN105079552A (en) | Preparation for treating prosopalgia and preparation method | |
| CN105343618A (en) | Traditional Chinese medicine preparation for fast treating herpes zoster | |
| CN105456720A (en) | Ointment for treating tuberculous meningitis | |
| CN105641225A (en) | Chinese medicine composition for treating vestibular neuritis and preparation method and application thereof | |
| CN105126052A (en) | Chinese herbal preparation for treating fundus hemorrhage | |
| CN105560513A (en) | Traditional Chinese medicine composition for treating facial nerve paralysis and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 336000, Jiangxi, Yichun, Yuanzhou District, bright moon Road, building 295, No. 2, 1-502 Applicant after: Liu Gengxi Address before: 250000 Qilihe Road, Licheng District, Shandong, China, No. 7, No. Applicant before: Liu Gengxi |
|
| CB02 | Change of applicant information | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160316 |
|
| WW01 | Invention patent application withdrawn after publication |