CN105031457A - Eye drops for treating conjunctivitis - Google Patents
Eye drops for treating conjunctivitis Download PDFInfo
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- CN105031457A CN105031457A CN201510600242.9A CN201510600242A CN105031457A CN 105031457 A CN105031457 A CN 105031457A CN 201510600242 A CN201510600242 A CN 201510600242A CN 105031457 A CN105031457 A CN 105031457A
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- conjunctivitis
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides eye drops for treating conjunctivitis. The eye drops for treating the conjunctivitis is prepared from roots of Asia belltree 25 g, all grass or roots of common calanthe 20 g, palmate girardinia herbs 18 g, semen plantaginis 16 g, Chinese dodder seeds 18 g, Chinese goldthread rhizome 18 g, herba taraxaci 25 g, cortex moutan 15 g, glossy privet fruit 25 g, tubers of stemona 20 g, folium artemisiae argyi 18 g, radix scrophulariae 15 g, rhizoma polygonati odorati 18 g and liquorice 5 g. The prepared eye drops can treat the conjunctivitis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of eye drop being used for the treatment of conjunctivitis and its preparation method and application.
Background technology
Conjunctivitis is ophthalmology common disease, frequently-occurring disease, and its principal character is that onset is anxious, rapid onset, and conjunctival congestion and mycopus sexual secretion, eye has gargalesthesia, foreign body sensation, burn feeling etc.This disease is mainly in spring and autumn, and the reason caused mostly is caused by antibacterial or viral infection.Current Drug therapy is mainly western medical treatment and Chinese traditional treatment; Western medical treatment is mainly based on medicines such as chloromycetin, rifampicin, ciprofloxacins, and these medicine side effect are more common, and what have also has serious untoward reaction, and body easily produces toleration, very unfavorable to the health of people.The traditional Chinese medical science is in treatment acute conjunctivitis, and mainly based on Chinese patent medicine, conventional oral medicine, onset is comparatively slow, and cure rate is very low, easily recurs.External application Chinese medicine eye drop is little, and curative effect is undesirable, can not meet clinical needs.For this reason, be bursting to and develop the needs that more medicines for the treatment of conjunctivitis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of tinea unguium disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of eye drop being used for the treatment of conjunctivitis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix radermacherae sinicae 25g, Herba seu Radix Calanthes 20g, Herba Girardiniae Palmatae 18g, Semen Plantaginis 16g, Semen Cuscutae 18g, Rhizoma Coptidis 18g, Herba Taraxaci 25g, Cortex Moutan 15g, Fructus Ligustri Lucidi 25g, Radix Stemonae 20g, Folium Artemisiae Argyi 18g, Radix Scrophulariae 15g, Rhizoma Polygonati Odorati 18g, Radix Glycyrrhizae 5g.
The described eye drop being used for the treatment of conjunctivitis, dosage form is eye drop.
The described eye drop being used for the treatment of conjunctivitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, filter, being concentrated into 25 DEG C, to record relative density be 1.1-1.2, adding ethanol makes alcohol content reach 65%, cold preservation 24 hours, filter, it is 1.1 that filtrate recycling ethanol to 50 DEG C records relative density, adding ethanol makes alcohol content reach 75%, leave standstill 24 hours, filter, it is 1.1 that filtrate recycling ethanol to 50 DEG C records relative density, merge extracted twice filtrate and distillate, add sodium chloride 6g, ethyl hydroxybenzoate 0.2g, be stirred to dissolve, adding distil water is to 1000ml, reconciling pH with 5% sodium hydroxide solution is 6.5-7.5, add 0.2% active carbon again and boil 10 minutes, filter, subpackage, sterilizing, obtain eye drop.
The described application of eye drop in the eye drop of preparation treatment conjunctivitis being used for the treatment of conjunctivitis.
Radix radermacherae sinicae, formal name used at school: Radermacherasinica) be the plant of Bignoniaceae Kidney bean Pterostyrax, the root of Radix radermacherae sinicae, leaf, fruit can be done medicinal, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Generate heat for Sunstroke.Injury and bone fracture is controlled in external, venom, carbuncle.The present invention is used as medicine with root.
Herba seu Radix Calanthes is orchid calanthe herb or rhizome.Latin name: CalanthediscolorLindl., gathers after spending in spring, summer, cleans, using fresh herb or dry.Heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main scrofula infections; Carbuncle; Laryngopharynx swelling and pain; Hemorrhoid; Rheumatic arthralgia; Traumatic injury.The present invention is with all herbal medicine.
Herba Girardiniae Palmatae is herb or the root of contrayerva Herba Girardiniae Palmatae.Expelling pathogenic wind from the body surface, promoting the circulation of QI expectorant, Qinghuo Jiedu.Control the cough due to common cold, abundant expectoration uncomfortable in chest, skin is itched, sore.
Adhesion separation grass is the climing Lycopodium clavatum LycopodiumannotinumL of fern Lycopodiaceae Lycopodium plant China fir, with all herbal medicine.The four seasons can adopt, and dry or dry in the shade.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.For traumatic injury, waist hamstring bone pain, rheumatic numbness.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: Radix radermacherae sinicae of the present invention, Herba seu Radix Calanthes, Herba Girardiniae Palmatae, Semen Plantaginis, Semen Cuscutae, Rhizoma Coptidis heat-clearing and toxic substances removing, inflammation-dimishing and eye brightening are monarch drug, Herba Taraxaci, Cortex Moutan, Fructus Ligustri Lucidi, the Radix Stemonae, Folium Artemisiae Argyi, Radix Scrophulariae, Rhizoma Polygonati Odorati liver heat removing and eyesight improving are ministerial drug, Radix Glycyrrhizae is adjuvant, the effect of full side's heat-clearing and toxic substances removing, anti-inflammation, liver heat removing and eyesight improving, can treat multiple conjunctivitis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of eye drop embodiment: get Foliumet Ramulus Evodiae 25g, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 28g, Herba Cyathulae Prostratae 16g, Radix Cephalanthi Occidentalis 18g, Rhizoma Coptidis 18g, Radix Angelicae Dahuricae 25g, Semen Cassiae 15g, Herba Taraxaci 25g, Radix Scutellariae 20g, Folium Artemisiae Argyi 18g, Radix Pulsatillae 15g, Herba Portulacae 18g, Radix Glycyrrhizae 5g, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, filter, being concentrated into 25 DEG C, to record relative density be 1.1-1.2, adding ethanol makes alcohol content reach 65%, cold preservation 24 hours, filter, it is 1.1 that filtrate recycling ethanol to 50 DEG C records relative density, adding ethanol makes alcohol content reach 75%, leave standstill 24 hours, filter, it is 1.1 that filtrate recycling ethanol to 50 DEG C records relative density, merge extracted twice filtrate and distillate, add sodium chloride 6g, ethyl hydroxybenzoate 0.2g, be stirred to dissolve, adding distil water is to 1000ml, reconciling pH with 5% sodium hydroxide solution is 6.5-7.5, add 0.2% active carbon again and boil 10 minutes, filter, subpackage, sterilizing, obtain eye drop.
2, pharmaceutical preparation treatment conjunctivitis of the present invention clinical research
2.1 general data: this pharmaceutical preparation is applied to clinical observation conjunctivitis cases 40 example, wherein man 20 example, female 20 example, 15 ~ 40 years old age.The shortest person of the course of disease 1 week, most elder reaches February.
2.2 diagnostic criterias: determine according to national higher medical education teaching material " ophthalmology " and " ophthalmology pandect ".Morbidity is anxious, and the course of disease is short; Consciously to shed tears, foreign body sensation, burning sensation or pain etc. of itching.Conjunctival congestion, secretions is many.Be first mucus, afterwards in purulence, subconjunctival hemorrhage can occur.Cytolgical examination is polynucleosis.Observation index and standards of grading: observe patient's ophthalmalgia, shed tears, secretions, eyelid are red and swollen, and palpebral conjunctiva is congested, and bulbar conjunctiva hyperemia totally 6, is divided into 0 according to degree difference, 1,2,3 points of 4 grades.
2.3 test methods: prepare clinical sample by above-described embodiment preparation method, observation group eye drop 20ml prepared by the embodiment of the present invention 1 adds in 500ml normal saline solution, and irrigation of conjunctival sac eyes are about 100ml, every day 2 times.3 days courses for the treatment of, observe eye symptom and sign change, the record 1 time of marking every day, terminates rear judgement curative effect the course for the treatment of.Follow up a case by regular visits to after January.Use during medicine avoid eating anything raw or cold, pungent, stimulate and rotten thing.Blank group placebo.
2.4 criterions of therapeutical effect: recovery from illness: symptom and sign all disappears; Effective: symptomatology disappears or cardinal symptom sign disappears; Effective: cardinal symptom sign disappears substantially; Invalid: each side symptom and sign is without improvement.
2.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 20 | 5 | 12 | 3 | 85 |
| Blank group | 20 | 1 | 3 | 14 | 20 |
Visible, the medicine that the present invention obtains can safe and effective treatment conjunctivitis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the eye drop of conjunctivitis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix radermacherae sinicae 25g, Herba seu Radix Calanthes 20g, Herba Girardiniae Palmatae 18g, Semen Plantaginis 16g, Semen Cuscutae 18g, Rhizoma Coptidis 18g, Herba Taraxaci 25g, Cortex Moutan 15g, Fructus Ligustri Lucidi 25g, Radix Stemonae 20g, Folium Artemisiae Argyi 18g, Radix Scrophulariae 15g, Rhizoma Polygonati Odorati 18g, Radix Glycyrrhizae 5g.
2. be used for the treatment of the eye drop of conjunctivitis as claimed in claim 1, it is characterized in that, dosage form is eye drop.
3. be used for the treatment of the eye drop of conjunctivitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, filter, being concentrated into 25 DEG C, to record relative density be 1.1-1.2, adding ethanol makes alcohol content reach 65%, cold preservation 24 hours, filter, it is 1.1 that filtrate recycling ethanol to 50 DEG C records relative density, adding ethanol makes alcohol content reach 75%, leave standstill 24 hours, filter, it is 1.1 that filtrate recycling ethanol to 50 DEG C records relative density, merge extracted twice filtrate and distillate, add sodium chloride 6g, ethyl hydroxybenzoate 0.2g, be stirred to dissolve, adding distil water is to 1000ml, reconciling pH with 5% sodium hydroxide solution is 6.5-7.5, add 0.2% active carbon again and boil 10 minutes, filter, subpackage, sterilizing, obtain eye drop.
4. be used for the treatment of the application of eye drop in the eye drop for the treatment of conjunctivitis of conjunctivitis according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510600242.9A CN105031457A (en) | 2015-09-20 | 2015-09-20 | Eye drops for treating conjunctivitis |
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| CN201510600242.9A CN105031457A (en) | 2015-09-20 | 2015-09-20 | Eye drops for treating conjunctivitis |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943630A (en) * | 2005-10-08 | 2007-04-11 | 曾雄辉 | Eye medicine for preventing and treating conjunctivitis and keratitis and its preparing method |
| CN101549118A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating red-eye disease and preparation method thereof |
| CN103211869B (en) * | 2013-05-13 | 2013-12-04 | 陕西立众制药有限公司 | Traditional Chinese medicine eye drops used for treating acute conjunctivitis and preparation method thereof |
| CN104274734A (en) * | 2014-11-01 | 2015-01-14 | 刘树芹 | Traditional Chinese medicine composition for treating acute conjunctivitis |
| CN104367848A (en) * | 2014-10-20 | 2015-02-25 | 安徽省颍上县中医院 | Traditional Chinese medicine composition for treating conjunctivitis |
-
2015
- 2015-09-20 CN CN201510600242.9A patent/CN105031457A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943630A (en) * | 2005-10-08 | 2007-04-11 | 曾雄辉 | Eye medicine for preventing and treating conjunctivitis and keratitis and its preparing method |
| CN101549118A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating red-eye disease and preparation method thereof |
| CN103211869B (en) * | 2013-05-13 | 2013-12-04 | 陕西立众制药有限公司 | Traditional Chinese medicine eye drops used for treating acute conjunctivitis and preparation method thereof |
| CN104367848A (en) * | 2014-10-20 | 2015-02-25 | 安徽省颍上县中医院 | Traditional Chinese medicine composition for treating conjunctivitis |
| CN104274734A (en) * | 2014-11-01 | 2015-01-14 | 刘树芹 | Traditional Chinese medicine composition for treating acute conjunctivitis |
Non-Patent Citations (1)
| Title |
|---|
| 朱燕仙: ""龙胆泻肝汤治反复发作性结膜炎9例报道"", 《时珍国医国药》 * |
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