CN104784398A - Externally-applied ointment for treating stroke sequelae and preparation method thereof - Google Patents
Externally-applied ointment for treating stroke sequelae and preparation method thereof Download PDFInfo
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- CN104784398A CN104784398A CN201510255116.4A CN201510255116A CN104784398A CN 104784398 A CN104784398 A CN 104784398A CN 201510255116 A CN201510255116 A CN 201510255116A CN 104784398 A CN104784398 A CN 104784398A
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Abstract
The invention discloses an externally-applied ointment for treating stroke sequelae and a preparation method thereof. The preparation method of the ointment comprises the following steps: taking an extract of traditional Chinese medicine decoction pieces which consist of the following components in parts by mass: 10 parts of Japanese honeysuckle, 15 parts of heartleaf houttuynia herb, 10 parts of vietnamese sophora root, 10 parts of Sichuan rhubarb, 10 parts of liquorice root, 10 parts of cowherb seed, 15 parts of giant typhonium rhizome, 10 parts of camphor, 20 parts of milkvetch root, 10 parts of danshen root, 10 parts of white silkworm, 10 parts of scorpion, 15 parts of earthworm and 15 parts of gambir plant, and adding the extract into 100 parts of camphor and 1000 parts of vaseline in parts by mass. When in production, the preparation method specifically comprises the following steps: adding a mixture of the traditional Chinese medicine decoction pieces into ethanol, soaking for 15 days, pouring out soaking liquid, putting residual traditional Chinese medicines into a distillation pot, steaming for 2 hours at the environment of 100 DEG C, respectively purifying supernatant liquid obtained in the two steps, and pumping the liquid to obtain traditional Chinese medicine pure powder; and pouring vaseline into the pot for boiling, uniformly mixing with the traditional Chinese medicine pure powder, and uniformly mixing with camphor when cooling to 45 DEG C to prepare the ointment. The ointment disclosed by the invention is the externally-applied ointment; by adopting the ointment, pains and troubles of the bodies of patients can be avoided, and side effects of medicines on the visceral organs can also be avoided; the ointment is simple in treatment and significant in curative effects; and the preparation method is simple and reliable and can be used for easily preparing the required ointment.
Description
Technical field
The present invention relates to a kind of external-applied ointment being used for the treatment of apoplexy sequela and preparation method thereof.
Background technology
Apoplexy sequela, is also called hemiplegia, hemiplegia.Apoplexy is a name of disease of Chinese medicine, is also the general designations of people to acute cerebrovascular disease.Very accurately can reflect morbidity state and the process of disease visually, the speed of disease development is very rapidly, primary disease be from suddenly fainting, syncope, the distortion of commissure that occurs together, dysphonia, hemiplegia or without fainting into the class disease that stupor is cardinal symptom.Apoplexy comprises the cerebral hemorrhage, subarachnoid hemorrhage, cerebral infarction, transient ischemic attack etc. of modern medicine.Because this kind of disease onset is hurried, break with tremendous force, change of illness state is rapid, as natural wind, the thinking of ancient medicine analogy and called after " apoplexy ", because of its morbidity suddenly, be also called cerebrovas-cularaccident.China newly sends out paralytic about 2,200,000 people every year, dies from patient about 1,000,000 people of cerebrovascular every year, and patient's number (comprise and fully recovering) of existence is 600-700 ten thousand people, and cerebrovascular is the disease that disability rate is very high.According to statistics, in the cerebrovascular patient of survival, about have 25% disability to some extent, wherein severe disabled person accounts for 40%.About 3,000 ten thousand people of the annual neopathy in the whole world.General age of onset sickness rate more than 50 years old is the highest.The people that people about 30-40 year recent years suffers stroke also is increasing, and has the trend increased gradually.Apoplexy is a kind of commonly encountered diseases that whole world mortality rate is higher, the treatment of its apoplexy sequela, is the large problem that the whole world faces.
The Western medicine of traditional treatment cerebral hemorrhage disease has adona, thrombin, Trostin M, reptilase etc.In order to be stopped by cerebral hemorrhage as early as possible, quantity is all very large, after waiting until that brain is not hemorrhage, brings again serious cerebral thrombosis.The medicine of application cerebral thrombosis has that Ahylysantinfarctase, calciparine, Lumbrukinase, streptokinase, brain blood are logical, aspirin, gladly cut down the medicines such as it is stung, Folium Ginkgo.Some cerebral thrombosis patients eat aspirin for a long time, finally cause the dirty organ hemorrhage such as cerebral hemorrhage and dental hemorrhage.Long-term Oral is glad to be cut down it and stings and also can cause hepatorenal damage.Tcm therapy is oral Chinese medicine decoction or Chinese patent medicine.As: XIAOSHUAN TONGLUO PIAN, anti-embolism regenerative pill, PIANTAN FUYUAN WAN etc.Some application acupuncture-therapies, curative effect is long unsatisfactory.Through long-term western medicines in treatment apoplexy sequela, do not obtain satisfied curative effect.Acute stroke patients also there will be serious complication, as cerebral hernia, digestive tract hemorrhage, respiratory tract infection, decubital ulcer etc.Chronic patient takes medicine initiation hepatorenal damage for a long time, and serious patient can cause a series of complication such as general paralysis.
Summary of the invention
The object of this invention is to provide a kind of external-applied ointment for the treatment of apoplexy sequela and preparation method thereof, acute cerebral hemorrhage, cerebral thrombosis and patients with cerebral infarction generally rescue about one month in hospital, etc. using this medicinal ointment therapy after stable disease again, allow apoplexy sequela patient not take medicine, do not have an injection, not acupuncture-moxibustion, avoid pain and the worry of patient's body, turn avoid the side effect of medicine to internal organs official, treat simple, evident in efficacy.Preparation method simply, reliably, is easily grasped.
The object of the invention is to realize as follows: the external-applied ointment of this treatment apoplexy sequela, be by quality get Flos Lonicerae 10 parts, Herba Houttuyniae 15 parts, Radix Sophorae Tonkinensis 10 parts, 10 parts, Radix Et Rhizoma Rhei, 10 parts, Radix Glycyrrhizae, Semen Vaccariae 10 parts, Rhizoma Typhonii 15 parts, 10 parts, Radix Cinnamomi porrecti brain, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 10 parts, Bombyx Batryticatus 10 parts, Scorpio 10 parts, Pheretima 15 parts, Ramulus Uncariae Cum Uncis 15 parts the extractum of the prepared slices of Chinese crude drugs to camphorate 100 parts, vaseline 1000 parts of ointment made.
The method of the external-applied ointment of preparation above treatment apoplexy sequela, soak 15 days in 95% ethanol mixture of the prepared slices of Chinese crude drugs being joined 2 times of quality, every day stirs once, liquid will be bubbled out pour out, residue Chinese medicine is put in boiler and is steamed 2 hours under 100 ° of C environment, supernatant in above two steps is purified respectively and drains liquid, obtain the pure powder of Chinese medicine; Vaseline being fallen in pot and boil, put into the pure powder mixing of Chinese medicine, cooling to putting into Camphora mixing during 45 ° of C, obtained ointment.
Fang Xie: Flos Lonicerae, Herba Houttuyniae, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, heat radiation, disappear paralysis excretion.Radix Cinnamomi porrecti brain, Semen Vaccariae, Rhizoma Typhonii, Ramulus Uncariae Cum Uncis dredging collateral are invigorated blood circulation, blood stasis dispelling, detoxicating and resolving stagnation of pathogens, correct apoplexy facial hemiparalysis.The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae QI invigorating, blood pressure lowering, promotes neurocyte restore funcitons.Bombyx Batryticatus, Scorpio, Pheretima softening the hard mass blood stasis dispelling, walk to wear steepest, deeply with gap, can search and pick network tiltedly, grow liquid dredging collateral.Camphora has gentle stimulation and antisepsis to skin.Firmly embrocated and sent out effect red, also had slight anesthetic action, the nervus centralis of excited whole body, particularly remarkable for high-level center, blood circulation promoting and cardiotonic, be conducive to the function recovery of whole body.Full side is with blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral for aim, and blood stasis must be changed, and skew wind must be dispelled, and venation is in harmonious proportion, and blood flow is unimpeded, and muscle must be supported, therefore satisfactory effect.
Skin irritation test: get 32 kilograms of White Rabbits, respectively back hair is shaved off.Often whitewash rabbit back beyond the highest heavens 30 minutes with the ointment of preparation respectively, be used in conjunction 30 days, rub heat with the hands and rub with the hands red.Within every 24 hours, observe three times.Continuous painting stranding is observed for 30 days.The result of white rabbit skin irritation test is: occur without phenomenon that is red and swollen, that ooze out, go out blister, reaction without exception.Prove that this ointment is without skin wound repair, non-toxic reaction.
Therapeutic Method: external-applied ointment treatment apoplexy sequela patient.Back embrocated by mainstay cream, and centered by rubbing thoracic lumbar vertebrae sacral with the hands from C7, ointment embrocated by post.Critically ill patient also can increase the position of embrocating chest, abdominal part and extremity according to the state of an illness.Generally embrocate evenly, irradiate 20 minutes with infrared therapy apparatus 75 ° of C, once a day, 30 days is a course for the treatment of, and general treatment is till three months.
The diagnostic criteria of apoplexy sequela:
Computed tomography brain scan, to apoplexy diagnosis 100%, to ischemic apoplexy sequelae diagnosis more than 85%, apoplexy is diagnosed clear after 24 hours.
Blood sugar urinary sugar measures, and the treatment of apoplexy sequela and prognosis are very large with blood glucose relation.Fasting glucose is more than 11.12mmoL/L.Display damage of hypothalamus is serious, and mortality rate is high.
Magnetic resonance MRI 40 minutes processes, it is more accurate to diagnose.
Eosinophil count, the state of an illness is heavier, and acidophil is fewer.
Effect for the treatment of sequela of apoplexy standard:
Cure: patient clinical transference cure, check cerebral tissue through CT and recover normal, muscle strength reaches IV-V level, and individual takes care of oneself, handsome.
Effective: the clinical symptoms of patient disappears completely, CT examination is normal, muscular strength II-III grade, personal care.
Take a turn for the better: patient clinical symptom is obviously improved, and CT examination abnormal signal weakens, face, language and swallowing takes an evident turn for the better.Upper and lower extremities functional rehabilitation 60%, muscular strength reaches I level, personal care's difficulty.
Invalid: after clinical treatment, clinical symptoms does not occur that any symptom is improved.
Clinical experiment:
(1) treatment group: application of ointments treatment apoplexy sequela, once, treatment three months is restriction continuously in treatment every day.Treat disease patient after 496 routine apoplexy over nearly 3 years altogether, wherein, Aeg 400 example, aeg 96 example, the age is between 50 years old-75 years old.Cure 109 examples, cure rate 22%; Effective 123 examples, obvious effective rate 24.8%; Take a turn for the better 228 examples, improvement rate 46%; Invalid 36 examples, inefficiency 7.26%.Total effective rate is 92.7%
(2) matched group: select areal apoplexy sequela patient 60 example, the age 50-70 year between.Male 45 example, women 15 example, application hospital western medicines in treatment three months is restriction.Cure 8 examples, cure rate 13.3%; Effective 15 examples, obvious effective rate 25%; Take a turn for the better 13 examples, improvement rate 21.66%; Invalid 24 examples, inefficiency 40%.Total effective rate is 60%
Statistical result: matched group and treatment group significant difference.
The results show: external-applied ointment treatment apoplexy sequela, document has no similar report at home, in external-applied ointment treatment patient procedure, have following six kinds of discoveries:
(1) apoplexy sequela patient is under the outside stimulus of external-applied ointment, makes human body improve immunity, and the sickness rate of flu, fever reduces greatly.
(2) outside stimulus has heat-clearing and toxic substances removing, antiinflammatory, antibacterial, inflammation extinction tests, and blood laboratory leukocyte recovers normal.
(3) excite the natural protection ability having transferred body, repair power, the numerous disease that other human body exists disappears.
(4) by skin irritation, have activated hypophysis cerebri, change hormonal secretion, thus make the reproductive system such as sexual impotence, premature ejaculation illness obtain improvement.
(5) external-applied ointment has auxiliary therapeutic action to the disease beyond apoplexy sequela.
(6) Chinese medicine lotion for external use does not damage human body the five internal organs six mansion organ, has stopped the environment destroying human body because of drug side effect.
The present invention is external-applied ointment, pure Chinese medicine ingredients, allows apoplexy sequela patient not take medicine, does not have an injection, not acupuncture-moxibustion during treatment, avoids pain and the worry of patient's body, turn avoid the side effect of medicine to internal organs official, treat simple, evident in efficacy.Preparation method is simple and reliable, can easily prepare required ointment.
Detailed description of the invention
Embodiment 1
Get Flos Lonicerae 10g, Herba Houttuyniae 15g, Radix Sophorae Tonkinensis 10g, Radix Et Rhizoma Rhei 10g, Radix Glycyrrhizae 10g, Semen Vaccariae 10g Rhizoma Typhonii 15g, Radix Cinnamomi porrecti brain 10g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 10g, Bombyx Batryticatus 10g, Scorpio 10g, Pheretima 15g, the Ramulus Uncariae Cum Uncis 15g prepared slices of Chinese crude drugs and Camphora 100g, vaseline 1000g.95% ethanol putting into 2 times of quality with Chinese medicine crude drug soaks 15 days, and every day stirs once, will bubble out liquid and pour out, and residue Chinese medicine is put in boiler and steamed 2 hours under 100 ° of C environment, drains liquid, obtain the pure powder of Chinese medicine pure indescribably for twice supernatant Chinese medicine.Fallen by vaseline in pot and boil, put into the pure powder mixing of Chinese medicine, cool to 45 ° of C and put into Camphora mixing, obtain ointment, subpackage is for subsequent use.
Embodiment 2
Get Flos Lonicerae 10kg, Herba Houttuyniae 15kg, Radix Sophorae Tonkinensis 10kg, Radix Et Rhizoma Rhei 10kg, Radix Glycyrrhizae 10kg, Semen Vaccariae 10kg Rhizoma Typhonii 15kg, Radix Cinnamomi porrecti brain 10kg, Radix Astragali 20kg, Radix Salviae Miltiorrhizae 10kg, Bombyx Batryticatus 10kg, Scorpio 10kg, Pheretima 15kg, the Ramulus Uncariae Cum Uncis 15kg prepared slices of Chinese crude drugs and Camphora 100kg, vaseline 1000kg.95% ethanol putting into 340kg with Chinese medicine crude drug soaks 15 days, and every day stirs once, will bubble out liquid and pour out, and residue Chinese medicine is put in boiler and steamed 2 hours under 100 ° of C environment, drains liquid, obtain the pure powder of Chinese medicine pure indescribably for twice supernatant Chinese medicine.Fallen by vaseline in pot and boil, put into the pure powder mixing of Chinese medicine, cool to 45 ° of C and put into Camphora mixing, obtain ointment, subpackage is for subsequent use.
Claims (2)
1. treat an external-applied ointment for apoplexy sequela, it is characterized in that: be by quality get Flos Lonicerae 10 parts, Herba Houttuyniae 15 parts, Radix Sophorae Tonkinensis 10 parts, 10 parts, Radix Et Rhizoma Rhei, 10 parts, Radix Glycyrrhizae, Semen Vaccariae 10 parts, Rhizoma Typhonii 15 parts, 10 parts, Radix Cinnamomi porrecti brain, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 10 parts, Bombyx Batryticatus 10 parts, Scorpio 10 parts, Pheretima 15 parts, Ramulus Uncariae Cum Uncis 15 parts the extractum of the prepared slices of Chinese crude drugs to camphorate 100 parts, vaseline 1000 parts of ointment made.
2. prepare the method for the external-applied ointment for the treatment of apoplexy sequela according to claim 1 for one kind, it is characterized in that: be soak 15 days in 95% ethanol mixture of the prepared slices of Chinese crude drugs being joined 2 times of quality, every day stirs once, liquid will be bubbled out pour out, residue Chinese medicine is put in boiler and is steamed 2 hours under 100 ° of C environment, supernatant in above two steps is purified respectively and drains liquid, obtain the pure powder of Chinese medicine; Vaseline being fallen in pot and boil, put into the pure powder mixing of Chinese medicine, cooling to putting into Camphora mixing during 45 ° of C, obtained ointment.
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| CN105687798A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal preparation for treating stroke and preparation method of external traditional Chinese medicinal preparation |
| CN105709194A (en) * | 2016-03-22 | 2016-06-29 | 山东明人福瑞达卫生材料有限公司 | Traditional Chinese medicine composition for treating stroke and external preparation thereof and preparation method of external preparation |
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