CN100393349C - Analgetic - Google Patents
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- CN100393349C CN100393349C CNB2005100906799A CN200510090679A CN100393349C CN 100393349 C CN100393349 C CN 100393349C CN B2005100906799 A CNB2005100906799 A CN B2005100906799A CN 200510090679 A CN200510090679 A CN 200510090679A CN 100393349 C CN100393349 C CN 100393349C
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- rhizoma
- headache
- anisodamine
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- chloromycetin
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Abstract
The present invention relates to an anodyne which is a medicine preparation prepared by combining Chinese medicines including honeysuckle, rhizoma corydalis, notopterygium root, hemlock parsley, herba schizonepetae spike, fructus ammomi rotundus, amomum fruit and oxhorn powder, and western medicines of anisodamine, sodium acetylsalicylate and chloramphenicol. The anodyne can be prepared in preparation types of oral liquid, powder, tablet, capsule, granule, etc. The anodyne is especially suitable for treating headache and toothache, particularly refractory vascular headache and nerve headache.
Description
Technical field
The present invention relates to treat the pharmaceutical composition of pain, particularly treat the pharmaceutical composition of headache and toothache with being mainly used in of Chinese crude drug and Western medicine formulated in combination.
Background technology
Headache is a common disease, and its cause of disease and pathogenic process are varied.Except that nonspecific infection, microtrauma can cause that one crosses the headache, often can see repeatedly the headache that shows effect, is difficult to cure, as the headache due to the autonomic nervous dysfunction, vascular migraine etc.This type of intractable headache grievous injury patient's quality of life, also can bring out and increase the weight of some chronic diseases, even cause the intensive stress of human body and threat to life because have an intense pain.
The types of drugs of the treatment headache of clinical practice now is numerous, and effect characteristics and therapeutic effect differ, but are symptomatic treatment substantially, can temporarily alleviate or alleviating pain, at least a few hours, a couple of days, at most the several months, recurs and can not stop to have a headache.
In addition, toothache can relatedly cause headache, becomes the cause of disease of headache; Toothache also can independently exist.Toothache in its pain character, take place aspect the evolution to have many similarly to headache, the situation of its treatment measure and existing treatment technology also has some identical.So the treatment of headache and toothache remains a difficult problem medically.
Chinese medicine characteristics occurred much respectively having in characteristic and advantage that oneself is arranged aspect the treatment pain, and the Chinese patent medicine of certain curative effect is arranged.But these shortcomings that Chinese patent medicine ubiquity curative effect is lower, onset is slower.Therefore, performance Chinese medicine and western modern medicine advantage are separately learnt from other's strong points to offset one's weaknesses, and the combination of Chinese and Western medicine medicine of excavating better efficacy, side effect this type of pain of treatment still less is the needs of clinical treatment.
Summary of the invention
The object of the present invention is to provide a kind of medicine with the Chinese and western medicinal composition preparation, its manufacture method is easy, economical, and is easy to use, and treatment intractable headache and toothache are had sure effect.
Medicine of the present invention is the medicament of being made by following proportion raw material medicine combination, is expressed as by weight,
Flos Lonicerae 15～20 Rhizoma Corydalis 10～30 Rhizoma Et Radix Notopterygiis 15～30 Rhizoma Chuanxiongs 10～15
Herba Schizonepetae 10～30 Fructus Amomi Rotunduss (Semen Vignae Cylindricae bandit) 10～15 Fructus Amomis 10～20
Cornu Bubali powder 0.3～1.5 Anisodamine 0.06～0.12 sodium salicylate 6.5～13
Chloromycetin 6.5～13.
Above crude drug preferred weight proportioning is,
Flos Lonicerae 18～20 Rhizoma Corydalis 20～25 Rhizoma Et Radix Notopterygiis 20～25 Rhizoma Chuanxiongs 12～14
Herba Schizonepetae 20～25 Fructus Amomi Rotunduss (Semen Vignae Cylindricae bandit) 12～14 Fructus Amomis 15～18
Cornu Bubali powder 0.8～1.5 Anisodamine 0.08～0.11 sodium salicylate 8～12
Chloromycetin 8～12.
Above raw material of Chinese medicine medicine optimum weight proportioning is,
Flos Lonicerae 20 Rhizoma Corydalis 25 Rhizoma Et Radix Notopterygiis 25 Rhizoma Chuanxiongs 15 Herba Schizonepetaes 25
Fructus Amomi Rotundus (Semen Vignae Cylindricae bandit) 15 Fructus Amomis 20 Cornu Bubali powders 1.5 Anisodamine 0.1
Sodium salicylate 10 chloromycetin 10.
Use above crude drug, can adopt common process to make said any dosage form on the pharmaceutics, comprise dosage forms such as powder, tablet, capsule, granular pattern electuary, oral liquid, for clinical use.
In pharmaceutical composition of the present invention, Chinese medicine and western medicine is used, and can receive the effect for the treatment of both the principal and secondary aspects of a disease, quick-acting, effect of a specified duration.In Chinese crude drug, Flos Lonicerae heat-clearing and toxic substances removing, the antiinflammatory fire of dispelling; Rhizoma Corydalis has the promoting blood circulation and stopping pain effect, and is obvious to removing the effect of vasospasm pain especially; Notopterygium wind dispelling dehumidifying, expelling cold and relieving exterior syndrome are to remove noxious dampness; Gas in the Rhizoma Chuanxiong promoting the circulation of blood, Si Shengxin scurries, and joins the Herba Schizonepetae relieving the exterior syndrome with drugs of pungent in flavor and cool in nature; Fructus Amomi Rotundus (Semen Vignae Cylindricae bandit), Fructus Amomi consciousness-restoring and orifice-opening; The Cornu Bubali heat-clearing and toxic substances removing; Be equipped with Western medicine Anisodamine (Anisodaminum has another name called 654-2) relieving spasm to stop pain again, the analgesic and analgesia of sodium salicylate, chloromycetin anti-inflammation, be used for the treatment of toothache and various headache, instant effect, analgesic effect is obvious, have no side effect, and oral flavour of a drug are refrigerant good to eat clothes back spirit and QI cleaning.Pharmaceutical composition of the present invention is particularly suitable for treating vascular, nervous headache.
The inventor uses Drug therapy intractable headache 32 examples of the present invention and obtains good clinical efficacy.This is organized in 30 examples, male 20 examples, women 10 examples; 15～76 years old age, The median age 40 years old.All cases are that first main suit goes to a doctor with headache all, successively are diagnosed as vascular, nervous headache.The course of disease is the shortest 3 months, and is the longest 5 years.History of repeated attack is all arranged, and attack times is more than 3 times.
This is organized all cases and all gives pain relieving granule by the preparation of following embodiment 4 methods, uses 2 bags, warm boiled water, every day 2 times at every turn.
Select simultaneously 16 routine patients to use Cyproheptadine at random and do the pain relieving contrast,
The pain standard adopts 5 grades of pain stage divisions of WHO: 0 grade-no pain; I level-mild pain, intermittent pain; II level-moderate pain is lasting pain, and influence is had a rest; III level-severe pain is for continuing severe pain; IV level-extreme pain is for continuing severe pain, with perspiration, heart rate quickening, autonomic nervous dysfunction's symptom.The pain relief degree is pressed CR (alleviating fully), PR (part is alleviated), MR (little effect), SD (stablizing), the evaluation of NC (invalid) Pyatyi, and effectively case is CR+PR+MR.Therapeutic outcome such as table 1, table 2.
Table 1 treatment group is alleviated the statistical effect of intractable headache
Table 2 matched group is alleviated the statistical effect of intractable headache
Two groups of contrasts, the treatment group CR19 example of application medicine of the present invention, the PR13 example, total effective rate is 100%, uses the matched group of Cyproheptadine, the CR7 example, the PR5 example, total effective rate is 75%.Two groups there were significant differences, and P＜0.05 illustrates that medicine of the present invention is better than Cyproheptadine to the analgesic effect of headache.
The inventor also uses Drug therapy of the present invention because of toothache case 48 examples that periodontal disease causes, also obtains good result.This organizes male's 32 examples in 48 examples, women's 16 examples; 32～72 years old age, The median age 55 years old.All cases all give the oral liquid by following embodiment 1 method preparation, each 8 milliliters, one day 2～3 times.
The pain relief degree is pressed CR (alleviating fully), PR (part is alleviated), MR (little effect), SD (stablizing), the evaluation of NC (invalid) Pyatyi, and effectively case is CR+PR+MR.Therapeutic outcome.
Table 3 medicine of the present invention is alleviated the toothache statistical effect to 48 examples
Table 3 shows, uses Drug therapy toothache of the present invention, has the case of half many (25/48) just to take effect after one day in medication, and toothache has alleviation in various degree; Medication has the case toothache of half many (28/48) to alleviate (healing) fully after 3 days; Medication after 4 days the toothache of all case in various degree alleviation is all arranged.Respond well than at present clinical treatment commonly used toothache medicine.
In using Drug therapy headache of the present invention and toothache case process, all do not find untoward reaction.
The specific embodiment
The invention will be further described by the following examples.
Embodiment 1 produces oral liquid
Prescription: Flos Lonicerae 400 gram Rhizoma Corydalis 500 gram Rhizoma Et Radix Notopterygiis 500 gram Rhizoma Chuanxiongs 300
Herba Schizonepetae 500 gram Fructus Amomi Rotunduss (Semen Vignae Cylindricae bandit) 300 gram Fructus Amomis 400 grams
Cornu Bubali powder 30 Keshan hyoscyamine 1.8 gram sodium salicylate 200 gram chloromycetin 200 grams.
Preparation method: each Chinese medicine is decocted with water respectively 3 times, the each decoction 30～120 minutes merges decoction liquor and filters, and is concentrated into relative density 1.1 grams per milliliters, add the ethanol mix homogeneously, make mixed liquor contain alcohol 50%, left standstill 24 hours, get supernatant and reclaim ethanol, be condensed into the thick paste of relative density 1.3 grams per milliliters, oven drying at low temperature adds Western medicine Anisodamine, sodium salicylate and chloromycetin again, is modulated into oral liquid.
Present embodiment with Anisodamine 1.6 grams, sodium salicylate 200 grams, chloromycetin 200 grams, is made about 5000 milliliters of oral liquid, each oral 6～8 milliliters of adult, every day 2～3 times with raw material of Chinese medicine medicine 2830 grams.
Embodiment 2 produces tablet
Prescription: Flos Lonicerae 380 gram Rhizoma Corydalis 500 gram Rhizoma Et Radix Notopterygiis 400 gram Rhizoma Chuanxiongs 300 grams
Herba Schizonepetae 400 gram Fructus Amomi Rotunduss (Semen Vignae Cylindricae bandit) 300 gram Fructus Amomis 300 grams
Cornu Bubali powder 20 Keshan hyoscyamine 2.0 gram sodium salicylate 160 gram chloromycetin 240 grams.
Preparation method: each Chinese medicine is decocted with water respectively 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, be condensed into clear paste.In clear paste, add the Western medicine powder, mix well, make granule, rolling in blocks.
Present embodiment restrains with raw material of Chinese medicine medicine 2600, and Western medicine Anisodamine 2.0 grams, sodium salicylate 160 grams, chloromycetin 240 grams are made about 1500 of tablet.Each oral 2～3 of adult patients, every day 2～3 times.
Embodiment 3 produces capsule
Prescription: Flos Lonicerae 300 gram Rhizoma Corydalis 500 gram Rhizoma Et Radix Notopterygiis 500 gram Rhizoma Chuanxiongs 300 grams
Herba Schizonepetae 500 gram Fructus Amomi Rotunduss (Semen Vignae Cylindricae bandit) 300 gram Fructus Amomis 250 grams
Cornu Bubali powder 10 Keshan hyoscyamine 2.0 gram sodium salicylate 240 gram chloromycetin 180 grams.
Preparation method: each Chinese medicine is decocted with water respectively 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, be condensed into clear paste.In clear paste, add water medicine powder, make granule, spray-dried, make fine powder, the adding vegetable oil is mixed the back pelletize thoroughly and is made capsule in fine powder again.
Present embodiment restrains and chloromycetin 180 grams with crude drug Chinese medicine 2720 grams, Western medicine Anisodamine 2.0 grams, sodium salicylate 240, can be made into about 2000 of capsule.Each oral 3～4 of adult patients, every day 2～3 times.
Embodiment 4 produces electuary
Prescription: Flos Lonicerae 400 gram Rhizoma Corydalis 300 gram Rhizoma Et Radix Notopterygiis 600 gram Rhizoma Chuanxiongs 200 grams
Herba Schizonepetae 600 gram Fructus Amomi Rotunduss (Semen Vignae Cylindricae bandit) 200 gram Fructus Amomis 400 grams
Cornu Bubali powder 20 Keshan hyoscyamine 2.0 gram sodium salicylate 240 gram chloromycetin 180 grams.
Preparation method: each Chinese medicine is decocted with water respectively 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, be condensed into clear paste.In clear paste, add water medicine powder, make granule, make granule, spray-dried, be distributed into pouch.
Present embodiment restrains and chloromycetin 180 grams with crude drug 2720 grams, Western medicine Anisodamine 2.0 grams, sodium salicylate 240, can be made into about 900 bags of electuary, each 1～2 bag of adult patients, every day 2～3 times.
Claims (5)
1. an analgesic that is used for the treatment of headache and toothache is characterized in that, the raw material composition of making its active component is by weight ratio:
Flos Lonicerae 15～20 Rhizoma Corydalis 10～30 Rhizoma Et Radix Notopterygiis 15～30 Rhizoma Chuanxiongs 10～15
Herba Schizonepetae 10～30 Fructus Amomi Rotunduss 10～15 Fructus Amomis 10～20 Cornu Bubali powders 0.3～1.5
Anisodamine 0.06～0.12 sodium salicylate 6.5～13 chloromycetin 6.5～13.
2. the described analgesic of claim 1, the weight proportion of its crude drug be,
Flos Lonicerae 18～20 Rhizoma Corydalis 20～25 Rhizoma Et Radix Notopterygiis 20～25 Rhizoma Chuanxiongs 12～14
Herba Schizonepetae 20～25 Fructus Amomi Rotunduss 12～14 Fructus Amomis 15～18 Cornu Bubali powders 0.8～1.5
Anisodamine 0.08～0.11 sodium salicylate 8～12 chloromycetin 8～12.
3. the described analgesic of claim 1, the weight proportion of its crude drug be,
Flos Lonicerae 20 Rhizoma Corydalis 25 Rhizoma Et Radix Notopterygiis 25 Rhizoma Chuanxiongs 15 Herba Schizonepetaes 25 Fructus Amomi Rotunduss 15
Fructus Amomi 20 Cornu Bubali powders 1.5 Anisodamine 0.1 sodium salicylate 10 chloromycetin 10.
4. the described analgesic of the arbitrary claim of claim 1～3 is any dosage form of making powder, tablet, capsule, granular pattern electuary or oral liquid by common process.
5. the described analgesic of the arbitrary claim of claim 1～3 is used to prepare the medicine for the treatment of vascular, nervous headache.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100906799A CN100393349C (en) | 2005-08-22 | 2005-08-22 | Analgetic |
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| CNB2005100906799A CN100393349C (en) | 2005-08-22 | 2005-08-22 | Analgetic |
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| CN100393349C true CN100393349C (en) | 2008-06-11 |
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| CNB2005100906799A Expired - Fee Related CN100393349C (en) | 2005-08-22 | 2005-08-22 | Analgetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102266563A (en) * | 2011-07-13 | 2011-12-07 | 赵磊 | Compound analgesic composition and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049821C (en) * | 1995-08-17 | 2000-03-01 | 吕柏帆 | Medicine for curing tooth ache |
| CN1059106C (en) * | 1997-01-13 | 2000-12-06 | 中美合资四川太极制药有限公司 | Durg for curing headache and preparation technology thereof |
| CN1077795C (en) * | 1999-07-22 | 2002-01-16 | 蒋勤 | Chinese patent medicine for treating headache |
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2005
- 2005-08-22 CN CNB2005100906799A patent/CN100393349C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049821C (en) * | 1995-08-17 | 2000-03-01 | 吕柏帆 | Medicine for curing tooth ache |
| CN1059106C (en) * | 1997-01-13 | 2000-12-06 | 中美合资四川太极制药有限公司 | Durg for curing headache and preparation technology thereof |
| CN1077795C (en) * | 1999-07-22 | 2002-01-16 | 蒋勤 | Chinese patent medicine for treating headache |
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| CN1739761A (en) | 2006-03-01 |
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