CN1059106C - Durg for curing headache and preparation technology thereof - Google Patents
Durg for curing headache and preparation technology thereof Download PDFInfo
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- CN1059106C CN1059106C CN97100157A CN97100157A CN1059106C CN 1059106 C CN1059106 C CN 1059106C CN 97100157 A CN97100157 A CN 97100157A CN 97100157 A CN97100157 A CN 97100157A CN 1059106 C CN1059106 C CN 1059106C
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Abstract
The present invention relates to a medicine for treating headaches, which relates to a Chinese patent medicine, wherein the Chinese patent medicine is composed of the following active components: hemlock parsley, angelica dahurica, notopterygium root, asarum, mint, ledebouriella root, radix glycyrrhiza, tea leaf, red peony root, tall gastrodis tuber and chrysanthemum, and the Chinese patent medicine is prepared in a specific medicinal preparation method. The present invention has the functions of relieving headaches rapidly, promoting blood circulation for removing blood stasis, and dispelling wind for alleviating pain.
Description
The present invention is a kind of Chinese patent medicine that is used for the treatment of headache property disease, be specifically a kind of be the Chinese patent medicine that effective ingredient is prepared from the natural plant, belong to field of traditional Chinese.
In the prior art, the medicine that is used for the treatment of headache is a lot, for example, and rhizoma gastrodiae tablets for relieving headache, the dispelling wind Pain-Stopping Pill, or the like, still, owing to headache is due to many-sided reason, if the drug main symptomatic treatment of treatment headache clinically at present, said medicine can not all produce effect to all headaches.Though yet headache is a kind of symptom clinically, because its morbidity is anxious, patient is very painful during outbreak, solving pain relieving is pressing for of clinical treatment to alleviate the headache symptom, iff being to be main purpose with the pain relieving, according to theory of Chinese medical science, can not fundamentally eliminate the cause of disease of headache, this just cures the symptoms, not the disease.If to the patient is to take the treatment measure because of its cause of disease fully, then be unfavorable for alleviating as soon as possible or eliminating patient's misery.For this reason, the needs invention is a kind of can either effectively alleviate the headache symptom, can improve the treating both the principal and secondary aspects of a disease medicine of patient's pathomechanism again,
The object of the invention provides a kind of pharmaceutical composition that has treatment headache effect and have long-term effect.
Another object of the present invention provides a kind of Chinese patent medicine that can effectively treat headache.
Another object of the present invention provides a kind of preparation technology who treats the headache medicine.
Being prepared from of medicine of the present invention according to following technical scheme:
At first, according to the principles of formulating prescriptions of theory of Chinese medical science,, determine the raw material prescription of preparation medicine of the present invention according to secular clinical practice.
The said pharmaceutical composition with treatment headache effect of the present invention is made up of the medicine of following weight ratio:
Rhizoma Chuanxiong 50-200 part
Radix Angelicae Dahuricae 20-80 part
Rhizoma Et Radix Notopterygii 20-80 part
Herba Asari 5-20 part
Herba Menthae 50-150 part
Radix Saposhnikoviae 10-50 part
Radix Glycyrrhizae 10-50 part
Folium Camelliae sinensis 40-90 part
Radix Paeoniae Rubra 30-100 part
Rhizoma Gastrodiae 10-50 part
Flos Chrysanthemi 20-90 part
The preferred weight ratio of pharmaceutical composition each component of the present invention is:
Rhizoma Chuanxiong 100-150 part
Radix Angelicae Dahuricae 30-60 part
Rhizoma Et Radix Notopterygii 30-60 part
Herba Asari 5-15 part
Herba Menthae 60-90 part
Radix Saposhnikoviae 10-20 part
Radix Glycyrrhizae 15-25 part
Folium Camelliae sinensis 50-70 part
Radix Paeoniae Rubra 40-70 part
Rhizoma Gastrodiae 15-25 part
Flos Chrysanthemi 40-70 part
The more preferably weight ratio of pharmaceutical composition each component of the present invention is:
Rhizoma Chuanxiong 120-135 part
Radix Angelicae Dahuricae 35-50 part
Rhizoma Et Radix Notopterygii 35-50 part
Herba Asari 5-15 part
Herba Menthae 75-90 part
Radix Saposhnikoviae 10-20 part
Radix Glycyrrhizae 15-25 part
Folium Camelliae sinensis 55-65 part
Radix Paeoniae Rubra 50-60 part
Rhizoma Gastrodiae 15-25 part
The optimum weight ratio of Flos Chrysanthemi 50-600 part pharmaceutical composition each component of the present invention is:
127 parts of Rhizoma Chuanxiongs
42 parts of the Radixs Angelicae Dahuricae
42 parts of Rhizoma Et Radix Notopterygiis
10 parts of Herba Asaris
84 parts of Herba Menthaes
15 parts of Radix Saposhnikoviaes
21 parts in Radix Glycyrrhizae
63 parts of Folium Camelliae sinensis
53 parts of Radix Paeoniae Rubra
21 parts in Rhizoma Gastrodiae
53 parts of Flos Chrysanthemis
Medicine of the present invention is to be composition of raw materials with above-mentioned pharmaceutical composition, the pharmaceutical preparation that is prepared into according to the preparation process of routine.
The dosage form of medicine of the present invention can be acceptable clinically any dosage form, comprises liquid preparation, solid and semi-solid preparation and gas preparation.
The said liquid preparation of the present invention comprises oral liquid, suspension, syrup, injection, medicated wine, tincture etc.
Said solid of the present invention and semi-solid preparation comprise tablet, pill, unguentum, sublimed preparation, powder, granule, suppository, powder, masticatory, capsule etc.
The said gas preparation of the present invention comprises aerosol, inhalant etc.
The most preferably dosage form of medicine of the present invention is an oral liquid, through secular experimentation and clinical observation, finds to have outstanding curative effect according to the oral liquid of preparation technology's preparation of the present invention, and the preparation technology of this and medicine of the present invention has direct dependency.
The oral liquid of medicine of the present invention is prepared from according to following preparation technology:
According to above-mentioned best proportioning recipe quantity with Six-elements such as Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Herba Menthae, Radix Saposhnikoviae, Flos Chrysanthemi add that water 8-12 doubly measures, hydrodistillation collects 800 milliliters of Aromatic water, aqueous solution after distillation device is in addition collected, medicinal residues and Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Gastrodiae four flavors add water 3-10 and doubly measure twice of decoction, each decocting time is 0.5-1 hour, merge decocting liquid, filter; Filtering residue is abandoned.Folium Camelliae sinensis adds fresh boiling water 10-15 and doubly measures twice of immersion, each soak time is 20-60 minute, merge leachate, filter, the aqueous solution after filtrate and above-mentioned decocting liquid and the distillation merges, be evaporated to relative density 1.14 (70 ℃), leave standstill, be chilled to and add 1-3 after the room temperature and doubly measure 95% ethanol, stir evenly, cold preservation 24 hours makes precipitation.Get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, filtrate is concentrated into relative density 1.18 (room temperature).Above-mentioned Aromatic water with 0.8% tween 80 solubilising, is added in the above-mentioned concentrated solution, stir evenly, water is adjusted to 980 milliliters, is using 10%N
aOH regulates PH to 4.5-6.5, adds water again and adjusts total amount to 1000 milliliter, stirs evenly, and leaves standstill, filter, and fill, sterilization, promptly.
Medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, dispelling wind and relieving, the pharmacodynamic experiment data shows, medicine of the present invention reduces the cerebral ischemia zone, myelin basic protein content in the cerebrospinal fluid due to the reduction cerebral ischemic injury, significantly reduce bloodviscosity, reduce packed cell volume and erythrocyte aggregation index, significantly reduce viscous components, component of elasticity and the storage films amount of blood complex viscosity; And has the antagonism adrenalin hydrochloride to the arteriolar contraction of mesentery, significant prolongation clotting time and heat, chemical stimulation are caused pain have a significant analgesic activity.
Medicine of the present invention can be used for the treatment of various types of headaches clinically, plays the effect of relief of symptoms and healing.The patient particularly anxious for morbidity, that headache is serious takes medicine of the present invention, can reach the purpose of rapid releasing headache.
Embodiment 1
Prescription:
Rhizoma Chuanxiong 127 grams
The Radix Angelicae Dahuricae 42 grams
Rhizoma Et Radix Notopterygii 42 grams
Herba Asari 10 grams
Herba Menthae 84 grams
Radix Saposhnikoviae 15 grams
Radix Glycyrrhizae 21 grams
Folium Camelliae sinensis 63 grams
Radix Paeoniae Rubra 53 grams
Rhizoma Gastrodiae 21 grams
Flos Chrysanthemi 53 grams
Six-elements such as Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Herba Menthae, Radix Saposhnikoviae, Flos Chrysanthemi are added 10 times of amounts of water, hydrodistillation is collected 800 milliliters of Aromatic water, aqueous solution after distillation device is in addition collected, medicinal residues and Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Gastrodiae four flavors add 8 times of amounts of water and decoct twice, each decocting time is 1 hour, merge decocting liquid, filter; Filtering residue is abandoned.Folium Camelliae sinensis adds 12 times of amounts of fresh boiling water and soaks twice, each soak time is 20 minutes, merge leachate, filter, the aqueous solution after filtrate and above-mentioned decocting liquid and the distillation merges, and is evaporated to relative density 1.14 (70 ℃), leaves standstill, be chilled to the ethanol that adds 2 times of amounts 95% after the room temperature, stir evenly, cold preservation 24 hours makes precipitation.Get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, filtrate is concentrated into relative density 1.18 (room temperature).Above-mentioned Aromatic water with 0.8% tween 80 solubilising, is added in the above-mentioned concentrated solution, stir evenly, water is adjusted to 980 milliliters, is using 10%N
aOH regulates PH to 4.5-6.5, adds water again and adjusts total amount to 1000 milliliter, stirs evenly, and leaves standstill, filter, and fill, sterilization, promptly.
Embodiment 2
Rhizoma Chuanxiong 50 grams
The Radix Angelicae Dahuricae 20 grams
Rhizoma Et Radix Notopterygii 20 grams
Herba Asari 5 grams
Herba Menthae 50 grams
Radix Saposhnikoviae 10 grams
Radix Glycyrrhizae 10 grams
Folium Camelliae sinensis 40 grams
Radix Paeoniae Rubra 30 grams
Rhizoma Gastrodiae 10 grams
Flos Chrysanthemi 20 grams
Said medicine is pulverized, crossed 100 mesh sieves, add refined honey, make honeyed pill.
Embodiment 3
Rhizoma Chuanxiong 200 grams
The Radix Angelicae Dahuricae 20 grams
Rhizoma Et Radix Notopterygii 80 grams
Herba Asari 5 grams
Herba Menthae 50 grams
Radix Saposhnikoviae 50 grams
Radix Glycyrrhizae 10 grams
Folium Camelliae sinensis 90 grams
Radix Paeoniae Rubra 30 grams
Rhizoma Gastrodiae 10 grams
Flos Chrysanthemi 20 grams
Six-elements such as Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Herba Menthae, Radix Saposhnikoviae, Flos Chrysanthemi are added 10 times of amounts of water, hydrodistillation is collected 800 milliliters of Aromatic water, aqueous solution after distillation device is in addition collected, medicinal residues and Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Gastrodiae four flavors add 8 times of amounts of water and decoct twice, each decocting time is 1 hour, merge decocting liquid, filter; Filtering residue is abandoned, Folium Camelliae sinensis adds 12 times of amounts of fresh boiling water and soaks twice, and each soak time is 20 minutes, merges leachate, filter, aqueous solution after filtrate and above-mentioned decocting liquid and the distillation merges, and is evaporated to relative density 1.14 (70 ℃), leaves standstill, be chilled to the ethanol that adds 2 times of amounts 95% after the room temperature, stir evenly, cold preservation 24 hours makes precipitation.Get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, filtrate is concentrated into the extractum shape, adds above-mentioned Aromatic water, and mixing adds excipient starch, pelletize, and granulate is gone into the tablet machine tabletting then, makes tablet,
Claims (10)
1, a kind of pharmaceutical composition for the treatment of headache is characterized in that it is made by the medicine of following weight ratio:
Rhizoma Chuanxiong 50-200 part
Radix Angelicae Dahuricae 20-80 part
Rhizoma Et Radix Notopterygii 20-80 part
Herba Asari 5-20 part
Herba Menthae 50-150 part
Radix Saposhnikoviae 10-50 part
Radix Glycyrrhizae 10-50 part
Folium Camelliae sinensis 40-90 part
Radix Paeoniae Rubra 30-100 part
Rhizoma Gastrodiae 10-50 part
Flos Chrysanthemi 20-90 part.
2,, it is characterized in that the weight ratio of each component is according to the pharmaceutical composition of claim 1:
Rhizoma Chuanxiong 100-150 part
Radix Angelicae Dahuricae 30-60 part
Rhizoma Et Radix Notopterygii 30-60 part
Herba Asari 5-15 part
Herba Menthae 60-90 part
Radix Saposhnikoviae 10-20 part
Radix Glycyrrhizae 15-25 part
Folium Camelliae sinensis 50-70 part
Radix Paeoniae Rubra 40-70 part
Rhizoma Gastrodiae 15-25 part
Flos Chrysanthemi 40-70 part.
3,, it is characterized in that the weight ratio of each component is according to the pharmaceutical composition of claim 2:
Rhizoma Chuanxiong 120-135 part
Radix Angelicae Dahuricae 35-50 part
Rhizoma Et Radix Notopterygii 35-50 part
Herba Asari 5-15 part
Herba Menthae 75-90 part
Radix Saposhnikoviae 10-20 part
Radix Glycyrrhizae 15-25 part
Folium Camelliae sinensis 55-65 part
Radix Paeoniae Rubra 50-60 part
Rhizoma Gastrodiae 15-25 part
Flos Chrysanthemi 50-600 part.
4,, it is characterized in that the weight ratio of each component is according to the pharmaceutical composition of claim 3:
127 parts of Rhizoma Chuanxiongs
42 parts of the Radixs Angelicae Dahuricae
42 parts of Rhizoma Et Radix Notopterygiis
10 parts of Herba Asaris
84 parts of Herba Menthaes
15 parts of Radix Saposhnikoviaes
21 parts in Radix Glycyrrhizae
63 parts of Folium Camelliae sinensis
53 parts of Radix Paeoniae Rubra
21 parts in Rhizoma Gastrodiae
53 parts of Flos Chrysanthemis.
5, the arbitrary pharmaceutical composition among the claim 1-4, the dosage form of this medicine are any dosage forms in liquid preparation, solid and semi-solid preparation and the gas preparation.
6, according to the pharmaceutical composition of claim 5, said liquid preparation comprises oral liquid, suspension, syrup, injection, medicated wine, tincture.
7, according to the pharmaceutical composition of claim 5, said solid and semi-solid preparation comprise tablet, pill, unguentum, sublimed preparation, powder, granule, suppository, powder, masticatory, capsule.
8, according to the pharmaceutical composition of claim 5, said gas preparation comprises aerosol, inhalant.
9, a kind of oral liquor for the treatment of headache is characterized in that raw material prescription and process are:
Rhizoma Chuanxiong 127 grams
The Radix Angelicae Dahuricae 42 grams
Rhizoma Et Radix Notopterygii 42 grams
Herba Asari 10 grams
Herba Menthae 84 grams
Radix Saposhnikoviae 15 grams
Radix Glycyrrhizae 21 grams
Folium Camelliae sinensis 63 grams
Radix Paeoniae Rubra 53 grams
Rhizoma Gastrodiae 21 grams
Flos Chrysanthemi 53 grams
6.4 milliliters of tween 80s
Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Herba Menthae, Radix Saposhnikoviae, Flos Chrysanthemi Six-element are added water 8-12 doubly to be measured, hydrodistillation is collected 800 milliliters of Aromatic water, aqueous solution after distillation device is in addition collected, medicinal residues and Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Gastrodiae four flavors add water 3-10 and doubly measure twice of decoction, each decocting time is 0.5-1 hour, merge decocting liquid, filter; Filtering residue is abandoned, and Folium Camelliae sinensis adds fresh boiling water 10-15 and doubly measures immersion twice, and each soak time is 20-60 minute, merge leachate, filter, the aqueous solution after filtrate and above-mentioned decocting liquid and the distillation merges, and relative density is 1.14 when being evaporated to 70 ℃, leave standstill, be chilled to and add 1-3 after the room temperature and doubly measure 95% ethanol, stir evenly cold preservation, make precipitation, get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, filtrate is concentrated into that relative density is 1.18 under the room temperature, above-mentioned Aromatic water with 0.8% tween 80 solubilising, is added in the above-mentioned concentrated solution, stir evenly, water is adjusted to 980 milliliters, is using 10%N
aOH regulates PH to 4.5-6.5, adds water again and adjusts total amount to 1000 milliliter, stirs evenly, and leaves standstill, filter, and sterilization, promptly.
10,, it is characterized in that method for making is according to the oral liquor of claim 9:
Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Herba Asari, Herba Menthae, Radix Saposhnikoviae, Flos Chrysanthemi Six-element are added 10 times of amounts of water, hydrodistillation is collected 800 milliliters of Aromatic water, aqueous solution after distillation device is in addition collected, medicinal residues and Radix Glycyrrhizae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Gastrodiae four flavors add 8 times of amounts of water and decoct twice, each decocting time is 1 hour, merge decocting liquid, filter; Filtering residue is abandoned, and Folium Camelliae sinensis adds 12 times of amounts of fresh boiling water and soaks twice, and each soak time is 20 minutes, merge leachate, filter, the aqueous solution after filtrate and above-mentioned decocting liquid and the distillation merges, and relative density is 1.14 when being evaporated to 70 ℃, leave standstill, be chilled to the ethanol that adds 2 times of amounts 95% after the room temperature, stir evenly cold preservation 24 hours, make precipitation, get the supernatant decompression recycling ethanol, leave standstill, get supernatant and filter, filtrate is concentrated into that relative density is 1.18 under the room temperature, above-mentioned Aromatic water with 0.8% tween 80 solubilising, is added in the above-mentioned concentrated solution, stir evenly, water is adjusted to 980 milliliters, is using 10%N
aOH regulates PH to 4.5-6.5, adds water again and adjusts total amount to 1000 milliliter, stirs evenly, and leaves standstill, filter, and sterilization, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97100157A CN1059106C (en) | 1997-01-13 | 1997-01-13 | Durg for curing headache and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97100157A CN1059106C (en) | 1997-01-13 | 1997-01-13 | Durg for curing headache and preparation technology thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1187994A CN1187994A (en) | 1998-07-22 |
| CN1059106C true CN1059106C (en) | 2000-12-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97100157A Expired - Lifetime CN1059106C (en) | 1997-01-13 | 1997-01-13 | Durg for curing headache and preparation technology thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1059106C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393349C (en) * | 2005-08-22 | 2008-06-11 | 蹇利明 | Analgetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455316C (en) * | 2004-06-30 | 2009-01-28 | 天津天士力制药股份有限公司 | Use of medicinal composition containing ligusticum wallichii for treating chronic brain blood supply deficiency |
| CN101095900B (en) * | 2007-07-10 | 2010-11-10 | 黑龙江省中医研究院 | Sichuan chrysanthemum pain-relieving capsule and method for preparing the same |
| CN101919968A (en) * | 2009-06-09 | 2010-12-22 | 太极集团有限公司 | New application of traditional Chinese medicine composition for treating headache |
| CN103110830A (en) * | 2009-06-09 | 2013-05-22 | 太极集团有限公司 | Application of traditional Chinese medicine composition for treating headache in preparation of medicaments for treating stroke |
| CN103110829A (en) * | 2009-06-09 | 2013-05-22 | 太极集团有限公司 | Application of traditional Chinese medicine composition for treating headache in preparation of medicaments for inhibiting platelet aggregation |
| CN101780131A (en) * | 2010-03-26 | 2010-07-21 | 鲍旭刚 | Drug for treating headache and preparation method thereof |
| CN103301327A (en) * | 2013-06-20 | 2013-09-18 | 史凤娥 | Medicine for treating headache and preparation method thereof |
| CN106109717A (en) * | 2016-08-31 | 2016-11-16 | 天津中新药业研究中心 | A kind of compositions treating headache and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87103254A (en) * | 1987-04-29 | 1987-12-23 | 朝阳中药厂 | The preparation method of rhizoma gastrodiae tablets for relieving headache |
-
1997
- 1997-01-13 CN CN97100157A patent/CN1059106C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87103254A (en) * | 1987-04-29 | 1987-12-23 | 朝阳中药厂 | The preparation method of rhizoma gastrodiae tablets for relieving headache |
Non-Patent Citations (4)
| Title |
|---|
| 《中原医刊》19(2) 1992.2.29 王永炎，川芎定痛饮治疗偏头痛45例临床初步观察 * |
| 《北京中医》(1) 1986.1.31 张炳厚等，川芎茶调散加减治疗多种内伤头痛 * |
| 《北京中医》(1) 1986.1.31 张炳厚等，川芎茶调散加减治疗多种内伤头痛;《北京中医学院学报》9(4) 1986.4.30 王永炎，川芎定痛饮治疗偏头痛45例临床初步观察;《中原医刊》19(2) 1992.2.29 王永炎，川芎定痛饮治疗偏头痛45例临床初步观察 * |
| 《北京中医学院学报》9(4) 1986.4.30 王永炎，川芎定痛饮治疗偏头痛45例临床初步观察 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393349C (en) * | 2005-08-22 | 2008-06-11 | 蹇利明 | Analgetic |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1187994A (en) | 1998-07-22 |
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