CN1876087A - A medicament for treating tension headache and preparation method thereof - Google Patents
A medicament for treating tension headache and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating cephalodynia and its preparing process, wherein the medicament is prepared from nine kinds of Chinese herbs including cyperus tuber, radix paeoniae rubrathe, Ligusticum wallichii and Chinese angelica root. The medicament can be made into the dosage forms of capsules, tablets, granules or liquids.
Description
Technical field
What the present invention relates to is a kind of have depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain effect, is used for the treatment of the medicament of tension headache, particularly described medicament be a kind of be the Chinese patent medicine that feedstock production forms with Chinese medicine.The invention still further relates to this medicaments preparation method.
Background technology
Tension headache is a kind of common disease, claiming muscle contraction headache, muscular tone headache, common headache, simple headache etc. again, is because suitable the loosening and have a rest and some dull work post makes head and neck or pectoral girdle be in bad posture etc. for a long time can to cause that the muscle persistence contraction of incidence and disturbance of blood circulation, ischemia fall ill of chronic anxiety, anxiety, melancholy, fatigue, high-intensity work shortage.Clinical manifestation is non-pulsation, chronicity and regular headache.Along with the development of society, people's work and rhythm of life are more and more faster, and operating pressure increases, and nervous study, keen competition etc. make the trend that the people who suffers from tension headache has to be increased year by year.The western medicine tension headache mainly uses tranquilizer, anti-inflammatory analgesic agent, muscle relaxation agent or tip circulation improving agent, uses these Drug therapy tension headaches that certain curative effect is arranged, but recurrence easily after the drug withdrawal is taken side effect for a long time and increased.Motherland's medical science thinks that headache is stagnant relevant with catharsis malfunction and the blood clots absorbing of liver, exactly stagnation of QI due to depression of the liver is carried out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs when therefore treating.The Chinese patent medicine that treatment headache card uses clinically has ZHENGTIAN WAN, ZHENNAONING, Tai Ji TONGTIAN KOUFUYE etc. all based on the exogenous wind that looses of dispelling.Publication number is the Chinese invention patent application of CN1562112 in addition, discloses a kind of Chinese medicine composition for the treatment of headache, and described pharmaceutical composition is by Rhizoma Chuanxiong, Ramulus Uncariae Cum Uncis, and Rhizoma Gastrodiae, Radix Paeoniae Rubra, Rhizoma Corydalis is formed.Publication number is that the Chinese invention patent application of CN1565529 discloses a kind of dropping pill formulation for the treatment of angioneurotic headache, and publication number is that the Chinese invention patent application of CN1116537 then discloses a kind of treatment intractable headache Chinese medicine composition that has.The medicine of above-mentioned disclosed treatment headache all is the medicine of the symptomatic treatment that provides from the various causes of disease of headache, all has certain effect.Yet above-mentioned disclosed medicine does not wherein have at the tension headache symptom, and the merit that plays depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain is used to treat stagnation of QI due to depression of the liver and the medicine that causes headache.
Summary of the invention
Purpose of the present invention provides a kind of medicament with depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain functional treatment tension headache.Another object of the present invention provides this medicaments preparation method.
Technical scheme of the present invention is based on such principle: motherland's medical science is thought: liver controlling conveyance and dispersion, and regulating functional activities of qi, liver happiness bar reaches dislikes depression, liver catharsis bar reaches, and then mechanism of qi is happy, as if specially lacking of proper care because of feelings, or spirit depressing, or anxiety and tense etc. all can influence the catharsis function of liver, and make irritability stasis.Liver storing blood, the operation of blood depends on the promotion of gas, the catharsis malfunction of liver, stagnation of QI due to depression of the liver, the interruption of service of blood then can take place in functional activity of QI being not smooth and the stasis of blood stagnates.Stagnation of QI and blood may bring about pain, qi depression to blood stasis, passages through which vital energy circulates is unfavorable, and the disease of pain just can be taken place.Screening has the present invention of the medicine composition of dispersing the stagnated live-QI to relieve the stagnation of QI promoting blood circulation and stopping pain effect, when gathering effect.
Medicament of the present invention is to be made by the raw material of following weight parts:
Rhizoma Cyperi 2.5-4.5 part Radix Paeoniae Rubra 3-4.5 part Rhizoma Chuanxiong 2.5-4.5 part
Radix Angelicae Sinensis 3-4.5 part Rhizoma Corydalis 2.5-4 part Herba Asari 0.5-1.5 part
Radix Angelicae Dahuricae 1.5-3 part Radix Scutellariae 1.5-3 part Radix Bupleuri 1-3 part.
The medicament that above-mentioned raw materials can be made into comprises capsule, tablet, granule or liquid dosage form.
With the method for above-mentioned raw materials preparation cost invention medicament be:
(1) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae with steam distillation 4～6 hours, extract volatile oil, the aqueous solution after distillation device is in addition collected standby.
(2) medicinal residues and Radix Paeoniae Rubra, Radix Bupleuri add Radix Scutellariae after adding water boil, amount of water is 6～9 times of medical material amount, decoct 1～4 time (each 0.5～1.5 hour), collecting decoction filters, filtrate and above-mentioned aqueous solution merge, amalgamation liquid is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60～80%, and cold preservation is spent the night, filter filtrate for later use.
(3) get 60～80% alcohol reflux 3～5 times that Rhizoma Corydalis adds 4～7 times of amounts, each 1.5～2.5 hours, merge alcohol extract, filter, pure liquid behind filtrate and the above-mentioned precipitate with ethanol merges, and reclaims ethanol, and is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), spray drying gets extract powder.
(4) get the beta-schardinger dextrin-of 5～8 times of amounts of volatile oil, add the water heating for dissolving of 80 times of amounts after, under constantly stirring, slowly add volatile oil, continue to stir 25～35 minutes, cold preservation is spent the night, the leaching inclusion complex, low temperature (30-60 ℃) drying is ground into fine powder, with above-mentioned extract powder mixing for standby use;
(5) above-mentioned mixed powder and adjuvant mix homogeneously and be prepared into granule, drying, packing then obtains granule of the present invention; It is encapsulated again that above-mentioned mixed powder and adjuvant are prepared into granule, and packing then obtains capsule of the present invention; Above-mentioned medicated powder and adjuvant are prepared into granule tabletting again, and packing then obtains tablet of the present invention.
(6) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae in addition with steam distillation 4～6 hours, it is standby after with the beta-schardinger dextrin-inclusion to extract volatile oil, and the aqueous solution after distillation device is in addition collected standby.
(7) above-mentioned medicinal residues and Radix Paeoniae Rubra, Radix Bupleuri add Radix Scutellariae after adding water boil, amount of water is 6-8 a times of medical material amount, decoct 1～4 time (each 0.5～1.5 hour), collecting decoction filters, filtrate and above-mentioned aqueous solution merge, amalgamation liquid is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60～80%, and cold preservation is spent the night, filter filtrate for later use.
(8) get 60～80% alcohol reflux 3～5 times that Rhizoma Corydalis adds 4～7 times of amounts, each 1.5～2.5 hours, merge alcohol extract, filter, pure liquid behind filtrate and the above-mentioned precipitate with ethanol merges, and reclaims ethanol, and to be concentrated into relative density be that the clear paste of 1.05～1.30 (50 ℃) is standby;
(9) get above-mentioned clear paste and add the purified water that 4-6 doubly measures, sedimentation 22-28 hour, water precipitating 2-4 time, it is standby to get supernatant concentration to relative density when 70 ℃ of heat surveys and be 1.05～1.30 extractum;
(10) get above-mentioned extractum and above-mentioned clathrate mix homogeneously, add an amount of protein sugar, sucrose, essence and purified water and be diluted to 80 ℃ of intermittent fever to survey relative densities be 1.05-1.20, fill, sterilization, packing promptly get liquid dosage form of the present invention.
The raw material of Chinese medicine that the present invention uses is the medicine of putting down in writing on the Chinese Pharmacopoeia, presses the processing and concocting method processing process of preparing Chinese medicine back of Chinese Pharmacopoeia regulation and uses.
Take the present invention of above-mentioned measure, have depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain function.Be used for the treatment of because of depression of liver-QI, the blood clots absorbing stagnates and the headache that causes, and its clinical symptoms is non-pulsation, chronicity and regular headache etc.
The present invention is prepared into extraction extractum, and making every milliliter of extractum contain the crude drug amount is the 3.5-4.5 gram, carries out pharmacodynamics test, and the result is as follows:
1, resolving depression pain relieving granule is to the influence of endogenous material induced mice headache model.
This test exhausts that with reserpine 5-HT causes mice headache model in the brain, observe resolving depression pain relieving granule to 5-hydroxy tryptamine in the brain (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), the influence of norepinephrine (NE) etc., the result shows, this medicine can obviously increase the content of interior 5-HT of mouse brain and metabolite 5-HIAA thereof, reduces the influence of NE.
2, resolving depression pain relieving granule is to the influence of anesthetized dog cerebral blood flow
This test is main observation index with the ICAF amount, observes the influence of resolving depression pain relieving granule to cerebral blood flow.The result shows that resolving depression pain relieving granule can significantly increase the dog cerebral blood flow, reduces cerebral vascular resistance; Arteriotony, heart rate, electrocardiogram there is not obvious influence.
3, the particulate analgesic activity of resolving depression pain relieving
Result of the test confirms, resolving depression pain relieving granule has a significant protective effect to chemical stimulation is pain caused, with the blank group significant difference is arranged relatively; To thermostimulation and electricity irritation are pain caused significant analgesia role arranged also.
4, resolving depression pain relieving granule is to the influence of mouse sleep time
This test lumbar injection pentobarbital sodium is observed the influence of resolving depression pain relieving granule for mouse sleep time.Result of the test confirms that resolving depression pain relieving granule can obviously prolong the length of one's sleep of mice, has certain analgesia.
5, resolving depression pain relieving granule is to the influence of rat blood rheological characteristic
This test causes the rat blood viscosity increased with macromolecule right rotary glycoside, behind the duodenal administration, observes the influence of resolving depression pain relieving granule to the rat blood rheological characteristic.The result shows that this medicine is blood viscosity lowering obviously.
6, this test causes rat rat's pial microcirculation disturbance with macromolecule right rotary glycoside, observes the influence of resolving depression pain relieving granule to the rat microcirculation disturbance.The result shows that this medicine is increasing blood flow speed obviously, improves the blood fluidised form.The rat's pial microcirculation disturbance there is significant protective effect.
4, conclusion
Results of pharmacodynamic test shows that the present invention has clear and definite depressed liver-energy dispersing and QI regulating, the effect of promoting blood circulation and stopping pain, is used for the treatment of tension headache, and is safe and effective.
Embodiment
Embodiment 1
Prescription
Rhizoma Cyperi 270 gram Radix Paeoniae Rubra 270 gram Rhizoma Chuanxiongs 270 grams
Radix Angelicae Sinensis 270 gram Rhizoma Corydalis 270 gram Herba Asaris 90 grams
The Radix Angelicae Dahuricae 180 gram Radix Scutellariaes 180 gram Radix Bupleuri 180 grams
Preparation method:
(1) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae with steam distillation 4 hours, extract volatile oil, the aqueous solution after distillation device is in addition collected standbyly, and medicinal residues are used in addition.
(2) above-mentioned medicinal residues and Radix Paeoniae Rubra, Radix Bupleuri add Radix Scutellariae after adding water boil, amount of water is 7 times of medical material amount, decoct 4 times (each 1.5 hours), collecting decoction filters, filtrate and above-mentioned aqueous solution merge, amalgamation liquid is concentrated into the clear paste that relative density is 1.05～1.10 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, and cold preservation is spent the night, filter filtrate for later use.
(3) get 60% alcohol reflux 4 times that Rhizoma Corydalis adds 5 times of amounts, each 2 hours, merge alcohol extract, filter, the pure liquid behind filtrate and the above-mentioned precipitate with ethanol merges, and reclaims ethanol, and being concentrated into the clear paste that relative density is 1.05～1.10 (50 ℃), spray drying gets extract powder.
(4) get the beta-schardinger dextrin-of 5 times of amounts of volatile oil, add the water heating for dissolving of 80 times of amounts after, under constantly stirring, slowly add volatile oil, continue to stir 25 minutes, cold preservation is spent the night, the leaching inclusion complex, low temperature (30 ℃) drying is ground into fine powder, with above-mentioned extract powder mixing for standby use;
(5) above-mentioned mixed powder and adjuvant mix homogeneously and be prepared into granule, drying, packing then obtains granule of the present invention;
(6) above-mentioned medicated powder and adjuvant are prepared into granule tabletting again, and packing then obtains tablet of the present invention.
(7) above-mentioned mixed powder is prepared into capsule with an amount of magnesium stearate mix homogeneously, and packing gets final product.
Embodiment 2
Prescription:
Rhizoma Cyperi 542 gram Radix Paeoniae Rubra 542 gram Rhizoma Chuanxiongs 542 grams
Radix Angelicae Sinensis 542 gram Rhizoma Corydalis 542 gram Herba Asaris 163 grams
The Radix Angelicae Dahuricae 325 gram Radix Scutellariaes 325 gram Radix Bupleuri 325 grams
Preparation method:
(1) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae with steam distillation 6 hours, extract volatile oil, the aqueous solution after distillation device is in addition collected standbyly, and medicinal residues are used in addition.
(2) all the other methods are identical with embodiment 1.
Embodiment 3
Prescription
Rhizoma Cyperi 417 gram Radix Paeoniae Rubra 417 gram Rhizoma Chuanxiongs 417 grams
Radix Angelicae Sinensis 417 gram Rhizoma Corydalis 417 gram Herba Asaris 125 grams
The Radix Angelicae Dahuricae 250 gram Radix Scutellariaes 250 gram Radix Bupleuri 250 grams
Preparation method
(1) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae with steam distillation 5 hours, extract volatile oil, the aqueous solution after distillation device is in addition collected standbyly, and medicinal residues are used in addition.
(2) all the other methods are identical with embodiment 1.
Embodiment 4
Rhizoma Cyperi 417 gram Radix Paeoniae Rubra 417 gram Rhizoma Chuanxiongs 417 grams
Radix Angelicae Sinensis 417 gram Rhizoma Corydalis 417 gram Herba Asaris 125 grams
The Radix Angelicae Dahuricae 250 gram Radix Scutellariaes 250 gram Radix Bupleuri 250 grams
Preparation method
(6) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae with steam distillation 4～6 hours, it is standby after with the beta-schardinger dextrin-inclusion to extract volatile oil, and the aqueous solution after distillation device is in addition collected standby.
(7) above-mentioned medicinal residues and Radix Paeoniae Rubra, Radix Bupleuri add Radix Scutellariae after adding water boil, amount of water is 6-8 a times of medical material amount, decoct 1～4 time (each 0.5～1.5 hour), collecting decoction filters, filtrate and above-mentioned aqueous solution merge, amalgamation liquid is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60～80%, and cold preservation is spent the night, filter filtrate for later use.
(8) get 60～80% alcohol reflux 3～5 times that Rhizoma Corydalis adds 4～7 times of amounts, each 1.5～2.5 hours, merge alcohol extract, filter, pure liquid behind filtrate and the above-mentioned precipitate with ethanol merges, and reclaims ethanol, and to be concentrated into relative density be that the clear paste of 1.05～1.30 (50 ℃) is standby;
(9) get above-mentioned clear paste and add the purified water that 4-6 doubly measures, sedimentation 22-28 hour, water precipitating 2-4 time, it is standby to get supernatant concentration to relative density when 70 ℃ of heat surveys and be 1.05～1.30 extractum;
(10) get above-mentioned extractum and above-mentioned clathrate mix homogeneously, add an amount of protein sugar, sucrose, essence and purified water and be diluted to 80 ℃ of intermittent fever to survey relative densities be 1.05-1.20, fill, sterilization, packing promptly get liquid dosage form of the present invention.
Claims (4)
1. medicament that is used for the treatment of tension headache is characterized in that described medicament is to be made by the raw material of following weight parts:
Rhizoma Cyperi 2.5-4.5 part Radix Paeoniae Rubra 3-4.5 part Rhizoma Chuanxiong 2.5-4.5 part
Radix Angelicae Sinensis 3-4.5 part Rhizoma Corydalis 2.5-4 part Herba Asari 0.5-1.5 part
Radix Angelicae Dahuricae 1.5-3 part Radix Scutellariae 1.5-3 part Radix Bupleuri 1-3 part
2. a kind of medicament that is used for the treatment of tension headache according to claim 1 is characterized in that described medicament comprises capsule, tablet, granule or liquid dosage form.
3. a kind of medicaments preparation method for the treatment of tension headache according to claim 1 and 2 is characterized in that the method that above-mentioned raw materials is prepared into medicament is:
(1) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae with steam distillation 4～6 hours, extract volatile oil, the aqueous solution after distillation device is in addition collected standby.
(2) medicinal residues and Radix Paeoniae Rubra, Radix Bupleuri add Radix Scutellariae after adding water boil, amount of water is 6～9 times of medical material amount, decoct 1～4 time (each 0.5～1.5 hour), collecting decoction filters, filtrate and above-mentioned aqueous solution merge, amalgamation liquid is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60～80%, and cold preservation is spent the night, filter filtrate for later use.
(3) get 60～80% alcohol reflux 3～5 times that Rhizoma Corydalis adds 4～7 times of amounts, each 1.5～2.5 hours, merge alcohol extract, filter, pure liquid behind filtrate and the above-mentioned precipitate with ethanol merges, and reclaims ethanol, and is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), spray drying gets extract powder.
(4) get the beta-schardinger dextrin-of 5～8 times of amounts of volatile oil, add the water heating for dissolving of 80 times of amounts after, under constantly stirring, slowly add volatile oil, continue to stir 25～35 minutes, cold preservation is spent the night, the leaching inclusion complex, low temperature (30-60 ℃) drying is ground into fine powder, with above-mentioned extract powder mixing for standby use;
(5) above-mentioned mixed powder and adjuvant mix homogeneously and be prepared into granule, drying, packing then obtains granule of the present invention; It is encapsulated again that above-mentioned mixed powder and adjuvant are prepared into granule, and packing then obtains capsule of the present invention; Above-mentioned medicated powder and adjuvant are prepared into granule tabletting again, and packing then obtains tablet of the present invention.
4. a kind of medicaments preparation method for the treatment of tension headache according to claim 3 is characterized in that the method that above-mentioned raw materials is prepared into medicament is:
(1) get Rhizoma Cyperi in the above-mentioned raw materials, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae in addition with steam distillation 4～6 hours, it is standby after with the beta-schardinger dextrin-inclusion to extract volatile oil, and the aqueous solution after distillation device is in addition collected standby.
(2) above-mentioned medicinal residues and Radix Paeoniae Rubra, Radix Bupleuri add Radix Scutellariae after adding water boil, amount of water is 6-8 a times of medical material amount, decoct 1～4 time (each 0.5～1.5 hour), collecting decoction filters, filtrate and above-mentioned aqueous solution merge, amalgamation liquid is concentrated into the clear paste that relative density is 1.05～1.30 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60～80%, and cold preservation is spent the night, filter filtrate for later use.
(3) get 60～80% alcohol reflux 3～5 times that Rhizoma Corydalis adds 4～7 times of amounts, each 1.5～2.5 hours, merge alcohol extract, filter, pure liquid behind filtrate and the above-mentioned precipitate with ethanol merges, and reclaims ethanol, and to be concentrated into relative density be that the clear paste of 1.05～1.30 (50 ℃) is standby;
(4) get above-mentioned clear paste and add the purified water that 4-6 doubly measures, sedimentation 22-28 hour, water precipitating 2-4 time, it is standby to get supernatant concentration to relative density when 70 ℃ of heat surveys and be 1.05～1.30 extractum;
(5) get above-mentioned extractum and above-mentioned clathrate mix homogeneously, add an amount of protein sugar, sucrose, essence and purified water and be diluted to 80 ℃ of intermittent fever to survey relative densities be 1.05-1.20, fill, sterilization, packing promptly get liquid dosage form of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100775871A CN100486626C (en) | 2006-04-27 | 2006-04-27 | A medicament for treating tension headache and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100775871A CN100486626C (en) | 2006-04-27 | 2006-04-27 | A medicament for treating tension headache and preparation method thereof |
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| CN1876087A true CN1876087A (en) | 2006-12-13 |
| CN100486626C CN100486626C (en) | 2009-05-13 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670732A (en) * | 2012-05-29 | 2012-09-19 | 陕西新药技术开发中心 | Medicament for treating headache |
| CN105194191A (en) * | 2015-11-06 | 2015-12-30 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating tension headache |
| CN105535857A (en) * | 2016-01-22 | 2016-05-04 | 綦升信 | Traditional Chinese medicine pills for treating tonus headache and preparing method of traditional Chinese medicine pills |
-
2006
- 2006-04-27 CN CNB2006100775871A patent/CN100486626C/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670732A (en) * | 2012-05-29 | 2012-09-19 | 陕西新药技术开发中心 | Medicament for treating headache |
| CN102670732B (en) * | 2012-05-29 | 2014-12-03 | 陕西新药技术开发中心 | Medicament for treating headache |
| CN105194191A (en) * | 2015-11-06 | 2015-12-30 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating tension headache |
| CN105535857A (en) * | 2016-01-22 | 2016-05-04 | 綦升信 | Traditional Chinese medicine pills for treating tonus headache and preparing method of traditional Chinese medicine pills |
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| Publication number | Publication date |
|---|---|
| CN100486626C (en) | 2009-05-13 |
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| CP03 | Change of name, title or address |
Address after: 535008, the Guangxi Zhuang Autonomous Region Qinzhou Qinzhou port Guangxi large waterfront industrial park Patentee after: Guangxi Bangqi Pharmaceutical Group Co., Ltd. Address before: 535008 Guangxi Qinzhou Qinzhou port Guangxi large scale industrial circles Patentee before: Guangxi Bangqi Pharmaceutical Co., Ltd. |