CN1876074A - A constipation-treating medicament and preparation method thereof - Google Patents
A constipation-treating medicament and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal preparation for treating piles and its preparing process, which is prepared from six kinds of Chinese medicinal herbs including broomrape, Chinese angelica root and achyranthes and cyathula root, and can be made into the dosage forms of capsules, tablets, granules or liquids.
Description
Technical field
What the present invention relates to is that a kind of to have the kidney warming benefit smart, and function of relaxing bowel is used for the treatment of the medicament of constipation, particularly described medicament be a kind of be the Chinese patent medicine that feedstock production forms with Chinese medicine.The invention still further relates to this medicaments preparation method.
Background technology
Constipation is a kind of commonly encountered diseases, frequently-occurring disease, and with advancing age, its sickness rate also increases gradually.Constipation removes and often causes proctalgia, anal fissure, forms outside scatoma and gastrolith, fecal ulcer, the proctoptosis etc., still brings out angina pectoris, myocardial infarction and cerebrovascular and manages unexpected inducement.Prolonged constipation also can be brought out rectal cancer.And the insufficiency of kidney-YANG constipation is one of pattern of syndrome the most common in the constipation patient.Its morbidity or increase visceral-qi consume, kidney yang deficiency because of the age; Or because of innate deficiency, plain body weakness causes insufficiency of kidney-YANG, makes the large intestine conduction function not normal and cause constipation, belongs to the constipation due to insufficiency category.Its characteristics of incidence is that patient's condition is touching, and the course of disease is very long, and with have a dizzy spell, symptoms such as soreness of the waist and knees, clear urine in large amounts, this type of constipation needs long-term medication treatment.At present, the medicine that is used for the treatment of constipation clinically is a lot, and is for the moment fast but a lot of medicine all is figure, often cause diarrhoea, stomachache after patient takes, and it is more constipated to cause stool after the drug withdrawal, and the fraud of further damage kidney yang is arranged.Motherland's medical science thinks that constipation has the branch of void, reality.Reality person causes evil indigestion intestinal, obstruction by pathogenic heat, the cold long-pending and stagnation of QI, and it is gentle that empty person causes intestinal to lose by the yang blood and qi deficiency, promotes unable.Real person should be led to and rushed down on method of treatment, and empty person Yi Run mends.The medicine that uses clinically of treatment constipation has based on the Maren Zipi ball of the merit of enriching blood for moistening the intestine etc., but many with broken stagnant medicine in the side, and does not have the product of the kidney invigorating, and the insufficiency of kidney-YANG constipation patient should not be obeyed for a long time; CONGRONG TONGBIAN KOUFUYE based on the YIN nourishing intestine moistening etc. is arranged, though set for the constipation of suffering from a deficiency of the kidney, it is inapplicable to the insufficiency of kidney-YANG constipation; Have based on the constipation of spleen invigorating logically etc., be the medicine of warming middle-JIAO relieving constipation, but the power deficiency of kidney-replenishing, with controlling the insufficiency of kidney-YANG constipation, unsatisfactory curative effect.Publication number is the Chinese invention patent application of CN1634336 in addition, discloses a kind of oral Chinese medicine preparation for the treatment of constipation, and described pharmaceutical composition is made up of Fructus Cannabis, Fructus Aurantii Immaturus, the Radix Paeoniae Alba.Publication number is the Chinese invention patent application of CN1194838, discloses a kind of have spleen invigorating, kidney nourishing water, and the Chinese medicine composition of the merit of QI and blood regulating, described pharmaceutical composition be by Natrii Sulfas, Radix Et Rhizoma Rhei (Radix Et Rhizoma Rhei), and Fructus Cannabis, Radix Codonopsis is formed.Publication number is that the Chinese invention patent application of CN1172673 then discloses a kind of Chinese medicine composition for the treatment of habitual constipation.The medicine of above-mentioned disclosed treatment constipation all is from the various causes of disease of constipation and the medicine of the symptomatic treatment that provides all has certain effect.Yet above-mentioned disclosed medicine does not wherein have the constipation symptom of the large intestine malfunction that causes at kidney yang deficiency, and it is smart to play the kidney warming benefit, and the merit of loosening bowel to relieve constipation is used for insufficiency of kidney-YANG and causes the medicine of constipation.
Summary of the invention
Purpose of the present invention provides that a kind of to have the kidney warming benefit smart, function of relaxing bowel and can treat the medicament that causes the not normal constipation of large intestine conduction function because of kidney yang deficiency.Another object of the present invention provides this medicaments preparation method.
Technical scheme of the present invention is based on such principle: motherland's medical science thinks that insufficiency of kidney-YANG is the one of the main reasons that causes constipation, and no matter the insufficiency of kidney-YANG constipation all demonstrates its unique characteristics of incidence from the physiological and pathological aspect or aspect the clinical symptoms.Tcm theory is thought, the kidney being in charge of discharge and retention of body fluid, the Yu Eryin that has one's ideas straightened out, department two just, kidney yang is lost empty, warm having no right,, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness can not the temperatureization kidney essense, it is not normal to gasify, promote unable, make the large intestine conduction function not normal due to.Therefore, it is smart that screening has the kidney warming benefit, and the present invention that the medicine of functions of loosening bowel relieving constipation is formed is when gathering effect.
Medicament of the present invention is to be made by the raw material of following weight parts:
Herba Cistanches 3.5-5.5 part Radix Angelicae Sinensis 3-5.5 part Radix Achyranthis Bidentatae 2.5-4.5 part
Fructus Aurantii 1-2.5 part Rhizoma Alismatis 1.5-3.5 part Rhizoma Cimicifugae 0.5-2.5 part
The medicament that above-mentioned raw materials can be made into comprises capsule, tablet, granule or liquid dosage form.
With the method for above-mentioned raw materials preparation cost invention medicament be:
(1) to be broken into fine powder standby for the Radix Angelicae Sinensis powder of getting in the above-mentioned raw materials 1/2 amount;
(2) Radix Angelicae Sinensis of getting Chinese medicine of the five flavours material such as Herba Cistanches, Radix Achyranthis Bidentatae, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae and surplus is in addition soaked after 0.5-1.5 hour and is decocted 0.5-1.5 hour at every turn 1-4 time.Collecting decoction filters, and it is 1.28-1.36 that filtrate is concentrated into 80 ℃ of intermittent fever survey relative densities, and it is standby to obtain clear paste;
(3) get above-mentioned clear paste, add the Radix Angelicae Sinensis fine powder, dry, pulverizing is sieved, mixing, and it is standby to get mixed powder;
(4) above-mentioned mixed powder incapsulates, and packing then obtains capsule of the present invention; Above-mentioned medicated powder and adjuvant are prepared into granule tabletting again, and packing then obtains tablet of the present invention; Above-mentioned medicated powder and adjuvant are prepared into granule, and packing then obtains granule of the present invention.
(5) or get Radix Achyranthis Bidentatae and add 45% alcohol reflux three times, each 1-2 hour, merge alcohol extract, filter, medicinal residues are standby; After filtrate recycling ethanol was extremely a small amount of, it was standby to get concentrated solution;
(6) five tastes such as all the other Herba Cistanches, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae were soaked 1-2 hour with above-mentioned medicinal residues, decoct 1-4 time, each 0.5-1.5 hour, collecting decoction, filter, filtrate and above-mentioned concentrated solution merge, and being concentrated into relative density is to add an amount of clarifier behind the 1.05-1.25, getting supernatant concentration to 70 a ℃ intermittent fever survey relative density is 1.05-1.25, and it is standby to get extractum;
(8) above-mentioned extractum adds an amount of sucrose, refined honey, with purified water dilution back fill, sterilization, is the liquid preparation of De Benming after the packing.
The raw material of Chinese medicine that the present invention uses is the medicine of putting down in writing on the Chinese Pharmacopoeia, presses the processing and concocting method processing process of preparing Chinese medicine back of Chinese Pharmacopoeia regulation and uses.
Take the present invention of above-mentioned measure, it is smart to have the kidney warming benefit, function of relaxing bowel.Be used for the treatment of the constipation that causes because of insufficiency of kidney-YANG, its clinical symptoms is a constipation, clear urine in large amounts, the vertigo, soreness of the waist and knees.
The present invention is prepared into capsule, and making every capsules contain the crude drug amount is 2.5-3.5 gram, carries out pharmacodynamic experiment research, and organizes in contrast with CONGRONG TONGBIAN KOUFUYE and to contrast, and the result is as follows:
One, androgen sample effect:
1, to intact animal's influence: administration treated animal adrenal gland, testis, seminal vesicle and levator ani weight and matched group relatively have no significant change
2, to the influence of insufficiency of kidney-YANG animal: administration treated animal seminal vesicle, levator ani weight, adrenal gland's weight and matched group more all are significantly increased.
Two, to the influence of " insufficiency of kidney-YANG " mice testosterone concentration: administration treated animal serum testosterone content all has the raising of highly significant.
Three, to the influence of " insufficiency of kidney-YANG " mice cyclic nucleotide: " insufficiency of kidney-YANG " treated animal serum cAMP and cGMP content have respectively and descend and rising trend, and the two odds ratio matched group obviously reduces; To the unbalance correction that all has to a certain degree of above-mentioned cyclic nucleotide system, the two ratio of administration treated animal is all organized apparently higher than " insufficiency of kidney-YANG " behind the animals administer.
Four, to the influence of intestine movement function:
1, to the influence of insufficiency of kidney-YANG mouse small intestine ahead running:
The JICHUAN capsule can make insufficiency of kidney-YANG animal intestinal propulsion rate obviously improve.
2, to the influence of the full intestinal ahead running of mice:
The full intestinal of administration animal advances the time that shortening is all arranged, and dosage is that the shortening of 6g/kg JICHUAN capsule propelling time is very obvious, shows that the JICHUAN capsule can obviously promote full intestinal ahead running.
3, the influence that rabbit is shunk at body intestinal tube collapsible tube:
Administration group intestinal tube contraction frequency has increase trend, and shrinkage amplitude is significantly increased.
Five, to the influence of mouse intestinal moisture absorption:
Administration group large intestine and small intestinal edema component and the equal significant difference of matched group.
Six, defecating feces excretion:
1, to intact animal's effect: administration treated animal muck and argol weight and contained humidity thereof all are significantly increased
2, to the effect of cold accumulation and constipation animal pattern:
The argol that the model group animal is discharged is heavy obviously to be reduced, and muck is heavy also minimizing trend, and its moisture is apparently higher than matched group; Administration treated animal muck and argol weight average are significantly increased, and moisture does not have significant change.
3, to the influence of dryness accumulated in the stomach and intestine dehydration constipation:
Administration group defecation is counted the trend of increase than matched group.
4, to stop up the to stagnate influence of constipation model of excess-heat: the JICHUAN capsule is counted to defecation in the animal 3 hours and is not seen and have a significant effect.
4, conclusion
The result shows through pharmacodynamic study, the present invention has tangible androgen effect to the insufficiency of kidney-YANG mice, and the intact animal is not had influence, and insufficiency of kidney-YANG mice serum testosterone concentration is obviously increased, the disorderly of its cyclic nucleotide system must be corrected, show that this invention has obvious restitution to insufficiency of kidney-YANG; Can also obviously promote insufficiency of kidney-YANG Slight Cold accumulation and constipation model mice that tangible defecating feces excretion is all arranged, but it only obviously increases intact animal's Informal water branch of discharging feces, and cold accumulation and constipation animal is unaffected, increase the trend of dryness accumulated in the stomach and intestine dehydration mice with constipation defecation in addition, mouse intestinal moisture absorption and the stagnant constipation model of excess-heat heap soil or fertilizer over and around the roots are not seen obvious influence.The kidney warming benefit that the above result of study and the present invention are had is smart, the effect of relaxing bowel unanimity.
Embodiment
Embodiment 1
Prescription
Herba Cistanches 230g Radix Angelicae Sinensis 230g Radix Achyranthis Bidentatae 160g
Fructus Aurantii 80g Rhizoma Alismatis 120g Rhizoma Cimicifugae 50g
Preparation method:
(1) getting in the above-mentioned raw materials Radix Angelicae Sinensis powder of 115g, to be broken into fine powder standby;
(2) Radix Angelicae Sinensis of getting Chinese medicine of the five flavours material such as Herba Cistanches, Radix Achyranthis Bidentatae, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae and surplus is in addition soaked after 1 hour and is decocted each 1 hour 2 times.Collecting decoction filters, and it is 1.28-1.36 that filtrate is concentrated into 80 ℃ of intermittent fever survey relative densities, and it is standby to obtain clear paste;
(3) get above-mentioned clear paste, add the Radix Angelicae Sinensis fine powder, dry, pulverizing is sieved, mixing, and it is standby to get mixed powder;
(4) above-mentioned mixed powder and appropriate amount of auxiliary materials mix homogeneously are prepared into the 700-900 capsules, and packing gets final product.
(5) above-mentioned medicated powder and appropriate amount of auxiliary materials mix homogeneously, be prepared into granule after, tabletting obtains tablet of the present invention, the packing get final product.
(6) above-mentioned medicated powder and adjuvant are prepared into granule, then obtain granule of the present invention, and packing gets final product.
Embodiment 2
Prescription:
Herba Cistanches 350g Radix Angelicae Sinensis 350g Radix Achyranthis Bidentatae 230g
Fructus Aurantii 120g Rhizoma Alismatis 170g Rhizoma Cimicifugae 78g
Preparation method:
(1) getting in the above-mentioned raw materials Radix Angelicae Sinensis powder of 175g, to be broken into fine powder standby;
(2) Radix Angelicae Sinensis of getting Chinese medicine of the five flavours material such as Herba Cistanches, Radix Achyranthis Bidentatae, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae and surplus is in addition soaked after 1 hour and is decocted each 1 hour 4 times.Collecting decoction filters, and it is 1.28-1.36 that filtrate is concentrated into 80 ℃ of intermittent fever survey relative densities, and it is standby to obtain clear paste;
(3) all the other methods are identical with embodiment 1.
Embodiment 3
Prescription
Herba Cistanches 290g Radix Angelicae Sinensis 290g Radix Achyranthis Bidentatae 195g
Fructus Aurantii 100g Rhizoma Alismatis 145g Rhizoma Cimicifugae 65g
Preparation method:
(1) getting in the above-mentioned raw materials Radix Angelicae Sinensis powder of 145g, to be broken into fine powder standby;
(2) Radix Angelicae Sinensis of getting Chinese medicine of the five flavours material such as Herba Cistanches, Radix Achyranthis Bidentatae, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae and surplus is in addition soaked after 1 hour and is decocted each 1 hour 3 times.Collecting decoction filters, and it is 1.28-1.36 that filtrate is concentrated into 80 ℃ of intermittent fever survey relative densities, and it is standby to obtain clear paste;
(3) all the other methods are identical with embodiment 1.
Embodiment 4
Herba Cistanches 290g Radix Angelicae Sinensis 290g Radix Achyranthis Bidentatae 195g
Fructus Aurantii 100g Rhizoma Alismatis 145g Rhizoma Cimicifugae 65g
Preparation method
(1) get Radix Achyranthis Bidentatae and add 45% alcohol reflux three times, each 1 hour, merge alcohol extract, filter, medicinal residues are standby; After filtrate recycling ethanol was extremely a small amount of, it was standby to get concentrated solution;
(2) five tastes such as all the other Herba Cistanches, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae were soaked 1 hour with above-mentioned medicinal residues, decoct 1-4 time, each 1 hour, collecting decoction, filter, filtrate and above-mentioned concentrated solution merge, and being concentrated into relative density is to add an amount of clarifier behind the 1.05-1.25, getting supernatant concentration to 70 a ℃ intermittent fever survey relative density is 1.05-1.25, and it is standby to get extractum;
(3) above-mentioned extractum adds an amount of sucrose, refined honey, with purified water dilution back fill, sterilization, promptly gets liquid preparation of the present invention after the packing.
Claims (4)
1. medicament that is used for the treatment of constipation is characterized in that described medicament is to be made by the raw material of following weight parts:
Herba Cistanches 3.5-5.5 part Radix Angelicae Sinensis 3-5.5 part Radix Achyranthis Bidentatae 2.5-4.5 part
Fructus Aurantii 1-2.5 part Rhizoma Alismatis 1.5-3.5 part Rhizoma Cimicifugae 0.5-2.5 part
2. a kind of medicament that is used for the treatment of constipation according to claim 1 is characterized in that described medicament comprises capsule, tablet, granule or liquid dosage form.
3. a kind of medicaments preparation method for the treatment of constipation according to claim 1 and 2 is characterized in that the method that above-mentioned raw materials is prepared into medicament is:
(1) to be broken into fine powder standby for the Radix Angelicae Sinensis powder of getting in the above-mentioned raw materials 1/2 amount;
(2) Radix Angelicae Sinensis of getting Chinese medicine of the five flavours material such as Herba Cistanches, Radix Achyranthis Bidentatae, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae and surplus is in addition soaked after 0.5-1.5 hour and is decocted 0.5-1.5 hour at every turn 1-4 time.Collecting decoction filters, and it is 1.28-1.36 that filtrate is concentrated into 80 ℃ of intermittent fever survey relative densities, and it is standby to obtain clear paste;
(3) get above-mentioned clear paste, add the Radix Angelicae Sinensis fine powder, dry, pulverizing is sieved, mixing, and it is standby to get mixed powder;
(4) above-mentioned mixed powder incapsulates, and packing then obtains capsule of the present invention; Above-mentioned mixed powder and adjuvant are prepared into granule tabletting again, and packing then obtains tablet of the present invention; Above-mentioned medicated powder and adjuvant are prepared into granule, and packing then obtains granule of the present invention.
4, a kind of medicaments preparation method for the treatment of constipation according to claim 3 is characterized in that the method that above-mentioned raw materials is prepared into medicament is:
(1) get Radix Achyranthis Bidentatae and add 45% alcohol reflux three times, each 1-2 hour, merge alcohol extract, filter, medicinal residues are standby; After filtrate recycling ethanol was extremely a small amount of, it was standby to get concentrated solution;
(2) five tastes such as all the other Herba Cistanches, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Alismatis, Rhizoma Cimicifugae were soaked 1-2 hour with above-mentioned medicinal residues, decoct 1-4 time, each 0.5-1.5 hour, collecting decoction, filter, filtrate and above-mentioned concentrated solution merge, and being concentrated into relative density is to add an amount of clarifier behind the 1.05-1.25, getting supernatant concentration to 70 a ℃ intermittent fever survey relative density is 1.05-1.25, and it is standby to get extractum;
(3) above-mentioned extractum adds an amount of sucrose, refined honey, with purified water dilution back fill, sterilization, is the liquid preparation of De Benming after the packing.
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| CN 200610077586 CN1876074A (en) | 2006-04-27 | 2006-04-27 | A constipation-treating medicament and preparation method thereof |
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| CN 200610077586 CN1876074A (en) | 2006-04-27 | 2006-04-27 | A constipation-treating medicament and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091194A (en) * | 2011-03-14 | 2011-06-15 | 山东省千佛山医院 | Traditional Chinese medicinal preparation for treating astriction |
| CN102258646A (en) * | 2011-07-06 | 2011-11-30 | 陕西中药研究所 | Preparation method of Jichuan pills |
| CN102697951A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Cistanche traditional Chinese medicine decoction for treating astriction and preparation method for decoction |
| CN102697992A (en) * | 2012-06-01 | 2012-10-03 | 李承平 | Medicine combination tablet with effects of warming the kidney and tonifying sperm |
| CN104383154A (en) * | 2014-11-28 | 2015-03-04 | 瑞阳制药有限公司 | Traditional Chinese medicine preparation for treating constipation and preparation method thereof |
| CN105106539A (en) * | 2015-09-02 | 2015-12-02 | 宋琳 | Traditional Chinese medicine enema for treating yang deficiency type cancerous constipation and nursing method |
| CN111658743A (en) * | 2019-03-07 | 2020-09-15 | 连军营 | Composition for treating constipation, oral preparation and application |
| CN114306465A (en) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, preparation and application |
-
2006
- 2006-04-27 CN CN 200610077586 patent/CN1876074A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091194A (en) * | 2011-03-14 | 2011-06-15 | 山东省千佛山医院 | Traditional Chinese medicinal preparation for treating astriction |
| CN102258646A (en) * | 2011-07-06 | 2011-11-30 | 陕西中药研究所 | Preparation method of Jichuan pills |
| CN102697992A (en) * | 2012-06-01 | 2012-10-03 | 李承平 | Medicine combination tablet with effects of warming the kidney and tonifying sperm |
| CN102697951A (en) * | 2012-06-15 | 2012-10-03 | 李良 | Cistanche traditional Chinese medicine decoction for treating astriction and preparation method for decoction |
| CN102697951B (en) * | 2012-06-15 | 2014-02-26 | 李良 | Cistanche traditional Chinese medicine decoction for treating astriction and preparation method for decoction |
| CN104383154A (en) * | 2014-11-28 | 2015-03-04 | 瑞阳制药有限公司 | Traditional Chinese medicine preparation for treating constipation and preparation method thereof |
| CN105106539A (en) * | 2015-09-02 | 2015-12-02 | 宋琳 | Traditional Chinese medicine enema for treating yang deficiency type cancerous constipation and nursing method |
| CN111658743A (en) * | 2019-03-07 | 2020-09-15 | 连军营 | Composition for treating constipation, oral preparation and application |
| CN114306465A (en) * | 2022-01-18 | 2022-04-12 | 云南省中医医院(云南中医药大学第一附属医院) | Traditional Chinese medicine composition for treating kidney-yang deficiency type constipation, preparation and application |
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