CN1438015A - Medicine for treating colontis and preparation method thereof - Google Patents
Medicine for treating colontis and preparation method thereof Download PDFInfo
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- CN1438015A CN1438015A CN 03113039 CN03113039A CN1438015A CN 1438015 A CN1438015 A CN 1438015A CN 03113039 CN03113039 CN 03113039 CN 03113039 A CN03113039 A CN 03113039A CN 1438015 A CN1438015 A CN 1438015A
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Abstract
The present invention relates to a Chinese medicine for curing colitis and its preparation method. Said medicine is an oral preparation made up by using 18 Chinese medicinal materials of drynaria root, phellodendron bark, white peony root, ovate atractylodes root, solidago, lindera root, condonopsis root, copperleaf and others through the processes of pulverizing, extraction with ethyl alcohol, decocting, concentration, vacuum drying and pulverizing, and the pharmacodynamic tests show that said medicine has the functions of regulating immunity, resisting inflammation, regulating bowel movement and stopping pain.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of colitis and preparation method thereof.
Background technology:
Colitis, especially chronic colitis are a kind of frequently-occurring disease, commonly encountered diseases, and with the outbreak repeatedly of stomachache, diarrhoea, protracted course of disease is a main symptom, brings misery and uneasiness to the patient.Still there is not the specific treatment medicine at present, though some Western medicine have certain curative effect, prolonged application, side effect is more.
Summary of the invention:
The objective of the invention is to problem, a kind of medicine for the treatment of colitis and preparation method thereof is provided at present treatment colitis existence.
The object of the present invention is achieved like this: a kind of medicine for the treatment of colitis is characterized in that: it is made by following bulk drugs:
Rhizoma Drynariae 10-15 part Cortex Phellodendri 3-7 part Radix Paeoniae Alba 3-7 part
Rhizoma Atractylodis Macrocephalae 5-10 part Herba Solidaginis 5-10 part Radix Linderae 3-7 part
Radix Codonopsis 3-7 part Herba Acalyphae 5-10 part Cortex Magnoliae Officinalis 3-7 part
Poria 3-7 part Rhizoma Alismatis 3-7 part Radix Saposhnikoviae 2-5 part
Semen Coicis 10-15 part Radix Et Rhizoma Rhei 2-5 part Ramulus Cinnamomi 2-5 part
Pericarpium Citri Reticulatae 3-7 part Semen Arecae 3-7 part Radix Glycyrrhizae 3-7 part
Optimum formula of the present invention is made by following bulk drugs:
5 parts of 5 portions of Radix Paeoniae Albas of 15 portions of Cortex Phellodendris of Rhizoma Drynariae
5 parts of 6 parts of Radixs Linderae of 5.5 parts of Herba Solidaginiss of the Rhizoma Atractylodis Macrocephalae
5 parts of 6 parts of Cortex Magnoliae Officinalis of 5 parts of Herba Acalyphaes of Radix Codonopsis
3 parts of 5 parts of Radix Saposhnikoviaes of 5 portions of Rhizoma Alismatis of Poria
3 parts of 3 parts of Ramulus Cinnamomi of 10 parts of Radix Et Rhizoma Rhei of Semen Coicis
5 parts in 5 portions of Radix Glycyrrhizaes of 5 portions of Semen Arecaes of Pericarpium Citri Reticulatae
The preparation method of medicine of the present invention is characterized in that:
A) Rhizoma Atractylodis Macrocephalae, Semen Coicis powder are broken into fine powder, it is standby to cross the 100-200 mesh sieve;
B) get Radix Saposhnikoviae, Cortex Magnoliae Officinalis, the Radix Linderae, Pericarpium Citri Reticulatae and Ramulus Cinnamomi, doubly measured 95% alcohol reflux 1-2 hour with 4-8, filter, filtrate recycling ethanol is 1.04-1.06 to relative density, and is standby;
C) will incorporate in Rhizoma Drynariae, Radix Codonopsis, Herba Solidaginis, Radix Glycyrrhizae, Semen Arecae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Acalyphae, Poria, the Radix Paeoniae Alba, the Rhizoma Alismatis by the medicinal residues after the step b alcohol extraction, soak after 30-60 minute and decoct 2 times, add for the first time the water that 8-10 doubly measures, decocted 2-3 hour, and added the water that 6-8 doubly measures for the second time, decocted 1-2 hour, filter respectively, merging filtrate, being concentrated into the medicinal liquid ratio is 1: 1, adds the ethanol extract that obtains by step b and is concentrated into thick paste (d＞1.30);
D) mixing fine powders of the adding Rhizoma Atractylodis Macrocephalae and Semen Coicis, vacuum drying (0.06-0.08Mpa,＜60 ℃) is pulverized, and crosses the 80-100 mesh sieve, forms to contain the particulate powder of active component, and makes various oral formulations.
According to theory of Chinese medical science, colitis is the deficiency in origin and excess in superficiality card, and it is an asthenia of both the spleen and kidney, and it is designated as damp and hot, controls suitable treating both the principal and secondary aspects of a disease.Rhizoma Drynariae is got by the side, the Rhizoma Atractylodis Macrocephalae is a monarch drug, with the kidney invigorating antidiarrheal, the spleen strengthening and damp drying.Getting Radix Codonopsis, Poria, Semen Coicis, Pericarpium Citri Reticulatae is ministerial drug, to strengthen the merit of the regulating the flow of vital energy of monarch drug, spleen invigorating, eliminating dampness by diuresis.Assistant is led to intestinal, sending down the abnormal ascending QI removing food stagnancy with Cortex Phellodendri, Herba Solidaginis, Herba Acalyphae, Rhizoma Alismatis, Radix Et Rhizoma Rhei, Semen Arecae with clearing heat and expelling damp, removing blood stasis; Help again with the Radix Paeoniae Alba, the Radix Linderae, Cortex Magnoliae Officinalis, Radix Saposhnikoviae, Ramulus Cinnamomi with the suppressing the hyperactive liver pain relieving, regulate the flow of vital energy that it is full to remove, double its mark of controlling.Make Radix Glycyrrhizae with invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription.Play the effect of kidney tonifying spleen, clearing heat and expelling damp, regulating QI to relieve pain, removing food stagnancy blood stasis dispelling altogether, be used for the chronic colitis card and belong to the double patient who sees damp-heat syndrome of asthenia of both the spleen and kidney.
Pharmacodynamics test:
(1) to the effect of Cavia porcellus cell immune response ulcer colitis
Get particulate powder crude drug (down together) 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, three dosage gastric infusions, every day 1 time, continuous 17 days, the Cavia porcellus cell immune response ulcer colitis that dinitrofluorobenzene is caused has the effect that alleviates pathological changes, anti-intestinal mucosa ulcer and necrosis, and was similar to the effect of positive control drug sulfasalazine.
(2) to the effect of rat ulcer colitis
Get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion, every day 1 time, continuous 31 days, can alleviate the lesion degree of rat ulcer colitis, reverse the decline of cellular immune function, its effect is similar to sulfasalazine.
(3) antiinflammatory action
1, gets the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, 1 gastric infusion, the Mice Auricle acute inflammation that xylol causes has the obvious suppression effect, and suppression ratio is 22.8-36.7%, with positive control drug hydrocortisone 25mgkg
-1Act on similar.
2, get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, 1 gastric infusion can obviously reduce the increase of the mouse peritoneal capillary permeability that acetic acid causes, and suppression ratio 51.5-61.6% is with positive control drug hydrocortisone 25mgkg
-1Act on similar.
3, get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, every day, gastric infusion was 1 time, and continuous 7 days, the rat paw edema that on Carrageenan causes had tangible antiinflammatory action, and effect was kept 4 hours.
Curative effect is reliable, and 4, get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion, continuous 9 days, buries the chronic granuloma that filter paper causes and the obvious suppression effect is arranged, suppression ratio 29.9-42.5% mice is subcutaneous at every day 1 time.
5, get the particulate powder 43.7kg that the present invention relates to
-1Gkg
-1, gastric infusion, every day 1 time, continuous 6 days, the delayed allergy that the mice dinitrofluorobenzene is brought out had the obvious suppression effect, with positive control drug hydrocortisone 25mgkg
-1Act on similar.And can obviously increase thymus and index and spleen index, and the positive controls hydrocortisone causes and loses weight, thymus and index and spleen index reduce.
(4) intestine movement function test
1, intestinal contents fltting speed test
(1) charcoal end propulsion trial: get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1, gastric infusion 1 time can be accelerated mouse small intestine charcoal end fltting speed, and showing has facilitation to the normal intestinal propulsion motion of mice.
(2) charcoal end efflux time test: get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion 1 time can obviously quicken mice row's melena time of occurrence and the defecation frequency in 6 hours, and the feces pool is wet, and showing has discharge function, strong than the effect of positive control drug neostigmine methylsulfate.
(3) to the influence of mice spleen-stomach deficiency-cold defecation: get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion 1 time can shorten defecation time and increase defecation frequency gavaging the mice spleen-stomach deficiency-cold constipation that frozen water causes, and has the enterokinesia of promotion effect.
(4) to the influence of mice spleen deficiency syndrome: get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion, continuous 8 days, causes the syndrome of spleen-deficiency mice that the discharge function of accelerating enterokinesia is arranged to Radix Et Rhizoma Rhei at every day 1 time.
2, intestine in vitro exercise test
The exsomatize result of the test of duodenum, jejunum and the spontaneous contractile motion of colon intestinal segment of rabbit proves, the perfusate drug level that the present invention relates to presents excitation when 0.637-1.274mg/ml, concentration is increased to 1.274-2.584mg/ml and then presents the biphasic effect that first excitement (of short duration) back suppresses (lastingly) when above.
(5) analgesic activity test
1, gets the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion 1 time can improve the pain threshold of reaction that the mice thermostimulation causes, and acting duration was above 105 minutes.
2, get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion 1 time, the mouse writhing reaction that 0.6% acetum is caused has the obvious suppression effect.
3, get the particulate powder 43.7gkg that the present invention relates to
-1, 21.8gkg
-1And 10.9gkg
-1, gastric infusion 1 time can improve mouse tail electricity irritation pain threshold.
Above-mentioned experimental result proves that the present invention has the immunity of adjusting, antiinflammatory action to Cavia porcellus cell immune response ulcer colitis and rat ulcer colitis, and various acute inflammation and chronic granulation tissue hyperplasia are all had significant antiinflammatory action.The analgesic test result of mice hot plate method, electrostimulation and chemical stimulation method proves that the present invention has analgesic activity.In addition, regulate the effect of intestine movement function in addition.Result of the test provides the pharmacodynamics foundation for the present invention treats colitis (especially chronic colitis).
The specific embodiment:
Embodiment 1:
Take by weighing following bulk drugs by weight:
Rhizoma Drynariae 165g Cortex Phellodendri 55g Radix Paeoniae Alba 55g
Rhizoma Atractylodis Macrocephalae 61g Herba Solidaginis 66g Radix Linderae 55g
Radix Codonopsis 55g Herba Acalyphae 66g Cortex Magnoliae Officinalis 55g
Poria 55g Rhizoma Alismatis 55g Radix Saposhnikoviae 55g
Semen Coicis 110g Radix Et Rhizoma Rhei 33g Ramulus Cinnamomi 33g
Pericarpium Citri Reticulatae 55g Semen Arecae 55g Radix Glycyrrhizae 55g
The above-mentioned raw materials medicine is prepared by following operation:
A) Rhizoma Atractylodis Macrocephalae, Semen Coicis powder are broken into fine powder, it is standby to cross 100 mesh sieves;
B) get Radix Saposhnikoviae, Cortex Magnoliae Officinalis, the Radix Linderae, Pericarpium Citri Reticulatae and Ramulus Cinnamomi, with 6 times of amount 95% alcohol refluxs 1 hour, filter, filtrate recycling ethanol is 1.04 standby to relative density;
C) medicinal residues after the above-mentioned alcohol extraction are incorporated in Rhizoma Drynariae, Radix Codonopsis, Herba Solidaginis, Radix Glycyrrhizae, Semen Arecae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Acalyphae, Poria, the Radix Paeoniae Alba, the Rhizoma Alismatis, soak half an hour, the water that adds for the first time 10 times of amounts, decocted two hours, and added the water of 8 times of amounts for the second time, decocted 1 hour, filter respectively, merging filtrate, being concentrated into the medicinal liquid ratio is 1: 1, adds ethanol extract and is concentrated into thick paste (d＞1.30).
D) mixing fine powders of the adding Rhizoma Atractylodis Macrocephalae and Semen Coicis, vacuum drying (0.07Mpa,＜60 ℃) is pulverized, and crosses 80 mesh sieves, forms the particulate powder that contains active component.
Embodiment 2:
The particulate powder with active component of preparation among the embodiment 1 is sub-packed in 1000 hard capsules, makes a kind of hard capsule for the treatment of colitis.
Embodiment 3:
Particulate powder with active component and the tablet of preparation among the embodiment 1 used always adjuvant such as lubricant, disintegrating agent, adhesive etc. mix, tabletting, make a kind of tablet for the treatment of colitis.
Embodiment 4:
Use the particulate powder with active component and the granule of preparation among the embodiment 1 always adjuvant such as lactose, dextrin and cyclamate etc. mix, granulation, drying, make a kind of granule for the treatment of colitis.
Embodiment 5:
The particulate powder with active component of preparation among the embodiment 1 is mixed with oral liquid adjuvant commonly used such as cyclamate etc., make a kind of oral liquid for the treatment of colitis.
Embodiment 6:
The particulate powder with active component of preparation among the embodiment 1 is mixed, splashed in the not miscible condensed fluid with drop pill adjuvant commonly used such as gelatin etc., make a kind of drop pill for the treatment of colitis.
Embodiment 7:
Use the particulate powder with active component and the soft capsule of preparation among the embodiment 1 always adjuvant such as lecithin etc. and mix, be sealed in the soft capsule material of making by gelatin etc., make a kind of soft capsule for the treatment of colitis.
Claims (10)
1, a kind of medicine for the treatment of colitis, it is characterized in that: it is made by following bulk drugs:
Rhizoma Drynariae 10-15 part Cortex Phellodendri 3-7 part Radix Paeoniae Alba 3-7 part
Rhizoma Atractylodis Macrocephalae 5-10 part Herba Solidaginis 5-10 part Radix Linderae 3-7 part
Radix Codonopsis 3-7 part Herba Acalyphae 5-10 part Cortex Magnoliae Officinalis 3-7 part
Poria 3-7 part Rhizoma Alismatis 3-7 part Radix Saposhnikoviae 2-5 part
Semen Coicis 10-15 part Radix Et Rhizoma Rhei 2-5 part Ramulus Cinnamomi 2-5 part
Pericarpium Citri Reticulatae 3-7 part Semen Arecae 3-7 part Radix Glycyrrhizae 3-7 part
2, the medicine of treatment colitis according to claim 1 is characterized in that: optimum formula is made by following bulk drugs:
5 parts of 5 portions of Radix Paeoniae Albas of 15 portions of Cortex Phellodendris of Rhizoma Drynariae
5 parts of 6 parts of Radixs Linderae of 5.5 parts of Herba Solidaginiss of the Rhizoma Atractylodis Macrocephalae
5 parts of 6 parts of Cortex Magnoliae Officinalis of 5 parts of Herba Acalyphaes of Radix Codonopsis
3 parts of 5 parts of Radix Saposhnikoviaes of 5 portions of Rhizoma Alismatis of Poria
3 parts of 3 parts of Ramulus Cinnamomi of 10 parts of Radix Et Rhizoma Rhei of Semen Coicis
5 parts in 5 portions of Radix Glycyrrhizaes of 5 portions of Semen Arecaes of Pericarpium Citri Reticulatae
3, the preparation method of claim 1 or 2 described medicines is characterized in that:
A) Rhizoma Atractylodis Macrocephalae, Semen Coicis powder are broken into fine powder, it is standby to cross the 100-200 mesh sieve;
B) get Radix Saposhnikoviae, Cortex Magnoliae Officinalis, the Radix Linderae, Pericarpium Citri Reticulatae and Ramulus Cinnamomi, doubly measured 95% alcohol reflux 1-2 hour with 4-8, filter, filtrate recycling ethanol is 1.04-1.06 to relative density, and is standby;
C) will incorporate in Rhizoma Drynariae, Radix Codonopsis, Herba Solidaginis, Radix Glycyrrhizae, Semen Arecae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Herba Acalyphae, Poria, the Radix Paeoniae Alba, the Rhizoma Alismatis by the medicinal residues after the step b alcohol extraction, soak after 30-60 minute and decoct 2 times, filter respectively, merging filtrate, being concentrated into the medicinal liquid ratio is 1: 1, adds the ethanol extract that obtains by step b and is concentrated into thick paste (d＞1.30);
D) mixing fine powders of the adding Rhizoma Atractylodis Macrocephalae and Semen Coicis, vacuum drying (0.06-0.08Mpa,＜60 ℃) is pulverized, and crosses the 80-100 mesh sieve, forms the particulate powder that contains active component.
4, according to the preparation method of the described medicine of claim 3, it is characterized in that: wherein step c soaks each medicine after 30-60 minute and decocts 2 times, add for the first time the water that 8-10 doubly measures, decocted 2-3 hour, and added the water that 6-8 doubly measures for the second time, decocted 1-2 hour, filter respectively, merging filtrate is concentrated into medicinal liquid than 1: 1, adds ethanol extract and is concentrated into thick paste (d＞1.30).
5, according to the preparation method of the described medicine of claim 3, it is characterized in that: the particulate powder that will have the active component hard capsule of packing into.
6, process for preparing medicine according to claim 3 is characterized in that: the particulate powder that will have active component is mixed with tablet adjuvant commonly used, tabletting, forms tablet.
7, the preparation method of medicine according to claim 3 is characterized in that: the particulate powder that will have an active component is mixed with granule adjuvant commonly used, granulation, drying, forms granule.
8, process for preparing medicine according to claim 3 is characterized in that: the particulate powder that will have active component is mixed with oral liquid adjuvant commonly used, correctives, forms oral liquid.
9, process for preparing medicine according to claim 3 is characterized in that: system is mixed, dripped to the particulate powder that will have active component with drop pill adjuvant commonly used, forms drop pill.
10, process for preparing medicine according to claim 3 is characterized in that: the particulate powder that will have active component is mixed with soft capsule adjuvant commonly used, makes soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03113039 CN1438015A (en) | 2003-03-24 | 2003-03-24 | Medicine for treating colontis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03113039 CN1438015A (en) | 2003-03-24 | 2003-03-24 | Medicine for treating colontis and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1438015A true CN1438015A (en) | 2003-08-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03113039 Pending CN1438015A (en) | 2003-03-24 | 2003-03-24 | Medicine for treating colontis and preparation method thereof |
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| Country | Link |
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| CN (1) | CN1438015A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537146B (en) * | 2008-03-19 | 2011-01-12 | 北京绿源求证科技发展有限责任公司 | Chinese medicine for treating carcinoma of colon |
| CN103784848A (en) * | 2014-01-15 | 2014-05-14 | 中国人民解放军第二军医大学 | Traditional Chinese medicinal composition for treating chronic colitis and preparation and application thereof |
| CN104826050A (en) * | 2015-04-28 | 2015-08-12 | 广西大学 | Traditional Chinese medicine composition for treating chronic ulcerative colitis and preparation method thereof |
| CN105748844A (en) * | 2016-04-11 | 2016-07-13 | 周晓娟 | Oral traditional Chinese medicine composition for treating migraine and preparation method thereof |
-
2003
- 2003-03-24 CN CN 03113039 patent/CN1438015A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537146B (en) * | 2008-03-19 | 2011-01-12 | 北京绿源求证科技发展有限责任公司 | Chinese medicine for treating carcinoma of colon |
| CN103784848A (en) * | 2014-01-15 | 2014-05-14 | 中国人民解放军第二军医大学 | Traditional Chinese medicinal composition for treating chronic colitis and preparation and application thereof |
| CN104826050A (en) * | 2015-04-28 | 2015-08-12 | 广西大学 | Traditional Chinese medicine composition for treating chronic ulcerative colitis and preparation method thereof |
| CN105748844A (en) * | 2016-04-11 | 2016-07-13 | 周晓娟 | Oral traditional Chinese medicine composition for treating migraine and preparation method thereof |
| CN105748844B (en) * | 2016-04-11 | 2019-06-18 | 周晓娟 | A kind of oral Chinese medicine composition and preparation method thereof for treating migraine |
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