CN1518995A - Medication for anti senile dementia as well as preparation method usage - Google Patents
Medication for anti senile dementia as well as preparation method usage Download PDFInfo
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Abstract
A Chinese medicine for preventing nerve cell injury, improving memory and treating sanile dementia is prepared from Chinese-medicinal materials including white peony root, ginseng, Chinese angelica root, liquorice root, etc.
Description
Technical field:
The present invention relates to a kind of is medicine, the Its Preparation Method And Use of raw material with the Chinese herbal medicine, and specifically a kind of is anti senile dementia drug, the Its Preparation Method And Use of feedstock production with the Chinese herbal medicine.
Background technology:
Senile dementia is meant that the infringement that continues appears in the acquired intelligence of geratic period appearance in itself, and just irreversible basically intelligence disappearance and the social adaptation that is caused by organic cerebral lesion reduces.The cause of disease of senile dementia takes place, unclear fully as yet at present.According to statistics, the sickness rate of senile dementia: over-65s is to be to be 30% more than 10%, 80 years old more than 5%, 70 years old, to more than 85 years old then up to 40%.Along with society enters aging, research prevention and treatment medicine for senile dementia become the task of top priority.In recent years, Chinese medicine has carried out series of experiment research and clinical application research aspect the prophylactic treatment senile dementia, obtained certain progress, has shown the advantage of Chinese medicine.
The Chinese traditional treatment dementia is used Chinese medicine compound more, according to theory of Chinese medical science, and kidney storing essence, the smart marrow of giving birth to, marrow leads in brain, so the kidney invigorating method is the common method for the treatment of senile dementia at present, as the nourishing kidney-YIN method, the warming the kidney to invigorate YANG method.According to above-mentioned pathomechanism, waking up the patient from unconsciousness by dissipating phlegm, promoting blood circulation to remove obstruction in the collateral also are main method simultaneously.Need use purging liver-fire again for some hyperactivity of hesrt-fire and liver-fire diseases and qi stagnation blood stasis disease (dysphoria type), the method for soothing the liver blood stasis dispelling, but most prescription has been taken into account it, generally based on reduce phlegm, medicine such as nourishing kidney, be auxilliary with suppressing the hyperactive liver, heat clearing away etc.
The clinical use of having reported at present or the Chinese medicine compound of research have Bolus as a Kidney-Yin-Tonic, and SHENGMAI YIN, BUYANG HUANWU TANG, DANGGUI SHAOYAO SAN, Rhizoma Coptidis toxic materials clearing away decoction, LIUWEI DIHUANG WAN, ginseng are returned decoct, Changchun, clearing heat in the pericardium pellet etc.Also have the therapeutic effect of pair single medicinal material (as Radix Ginseng, Ganoderma, Semen Ginkgo, Radix Paeoniae etc.) to study, many clinical and The pharmacological results show that the Chinese medicine senile dementia is evident in efficacy.
Disclose a kind of red preparation method of remembering in the Chinese patent application 96103426, it contains medicines such as Radix Ginseng, Poria, has the function of improving memory.Chinese patent application 97117052 discloses a kind of pharmaceutical composition for the treatment of senile dementia, and its composition contains Radix Ginseng, Rhizoma Acori Graminei.Chinese patent application 00109186 discloses a kind of medicine and preparation technology who prevents and treats alzheimer disease and depression, and this medicine is made up of Folium Ginkgo, Radix Ginseng and Herba Epimedii, has the alzheimer disease of control and curative effect of depression.
Because the universality and the seriousness of senile dementia morbidity, this disease is studied very necessary, comprise that development has the medicine of preventive effect.Chinese medicine has unique medical effect, so the Chinese medicine of exploitation treatment senile dementia has crucial meaning.
Summary of the invention:
The purpose of this invention is to provide a kind of anti senile dementia drug; this medicine is according to the theoretical compatibility of Chinese medical discrimination; have benefiting QI and nourishing blood, waking up the patient from unconsciousness by dissipating phlegm; the QI invigorating the kidney invigorating; take into account the function of dispersing the stagnated live-QI to relieve the stagnation of QI; neural cell injury is had effective protective effect, help hypermnesis, and obviously improve the senile dementia disease.
Another object of the present invention provides the preparation method of described anti senile dementia drug, and this method can extract the effective ingredient in the Chinese medicine, and preparation process is simple, the active constituent content height.
A further object of the present invention is to provide the purposes of this kind anti senile dementia drug on preparation treatment and prevention medicine for senile dementia.
Anti senile dementia drug of the present invention comprises the medicament that the raw material of following weight parts is made:
Radix Paeoniae Alba 1-40, Radix Ginseng 1-40, Radix Angelicae Sinensis 1-40, Radix Glycyrrhizae 1-40.
In order to strengthen curative effect, auxiliary said medicine effective ingredient plays a role, and anti senile dementia drug of the present invention also comprises the raw material of following weight parts:
Rhizoma Pinelliae 1-40, Poria 1-40, Rhizoma Acori Graminei 1-40, Radix Curcumae 1-40, Rhizoma Arisaematis 1-40; And/or
Radix Bupleuri 1-40, Semen Ziziphi Spinosae 1-40, Massa Medicata Fermentata 1-40.
Above-mentioned weight portion can be measurement units such as kilogram, gram, two, money, jin.
More than the method carried by water of each raw material obtain effective ingredient, and make said dosage form on any pharmaceutics.
Anti senile dementia drug of the present invention can also adopt other any methods of Chinese medicine to concoct, and makes said dosage form on any pharmaceutics.
Chinese medicine thinks that senile dementia declines for internal organs void, due to negative and positive of qi and blood loses.Because of the function deficiency, water-damp not being transformed is given birth in expectorant is turbid, so that goes up and cover clear key, and house of mental activity dysfunction is then refreshing slow-witted depressed, remembers and judges that all abilities go down, and each disease is given birth to therefrom.Control suitable benefiting QI and nourishing blood, the damp eliminating eliminating phlegm.Radix Ginseng in the side, the Radix Paeoniae Alba, Radix Angelicae Sinensis, the Radix Glycyrrhizae benefiting QI and nourishing blood is monarch to treat that internal organs void declines, wherein Radix Ginseng especially can strongly invigorating primordial QI, the gain of calming the nerves." herbal classic " calls its " tonifying five ZANG-organs, peace spirit decide soul ... happy Fructus Alpiniae Oxyphyllae ", " not record ": " making us not forgetting ", for refresh memory, improve judgement, calculating, thinking, abilities such as language truly have good effect; The Rhizoma Pinelliae, Poria, Rhizoma Acori Graminei, Radix Curcumae, the Rhizoma Arisaematis removing dampness is slitted paralysed, wards off the dirty minister that is, " herbal classic " meaning Rhizoma Acori Graminei " happy hole, tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity ... do not forget does not confuse, and prolongs life "; With the Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, Semen Ziziphi Spinosae tranquilizing by nourishing the heart, Massa Medicata Fermentata invigorating the spleen and regulating the stomach are to help again, and wherein Radix Bupleuri is unsociable and eccentric to improving disposition, and the individual character of narrow stubbornness has obvious curative effects; Answer with the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription to making.By the dialectical cooperation of said medicine, can effectively prevent and treat senile dementia.
Effective ingredient of the present invention boils crude drug by decocting and obtains, and its effective ingredient can be made the available dosage form on the pharmaceuticss such as granule, oral liquid, capsule, tablet, injection.
The preparation method of anti senile dementia drug of the present invention comprises the extraction of active constituents of medicine and the preparation of different dosage form, and the extraction of wherein said active constituents of medicine can be achieved by the following method:
The crude drug decoction pieces (crude drug) of various medicines is mixed, add the distilled water of 1-40 times of weight, decoct 1-3 time, each 1-3 hour; Each time decoction liquor 50-70 ℃ of following thin film evaporation, is concentrated to the 1/2-1/4 of original volume after merging, and filters, and obtains the active component of medicine.
Preferably after crude drug decoction pieces (crude drug) mixing with medicine, add the distilled water of 10 times of weight, decoct 3 times, each time time was respectively 2,2,1 hours, three decoction liquor was merged, 50-70 ℃ of following thin film evaporation, be concentrated to 1/3 of original volume, obtain the active component of medicine after the filtration.
In order to obtain the active component of medicine of the present invention better, can earlier crude drug be pulverized or porphyrize in the preparation, carry out water again and carry.
In the preparation process, crude drug can also be soaked, carry out water again and carry.
After obtaining the active component of medicine, as required, handle through different postorders, according to usual way, can adopt the prior art known method to make different dosage forms, as available dosage form on granule, oral liquid, capsule, tablet, injection or other pharmaceuticss.
Certainly if desired, various medicine materials of the present invention also can adopt the method for pharmacy of Chinese materia medica, raw material pulverizing are made medicaments such as pill, powder.
During use, medicine of the present invention was taken three times on the 1st, and each consumption is equivalent to primary dose 150 grams.
Use the pharmacodynamic experiment of medicine of the present invention:
(1) to the influence of scopolamine induced mice memory acquisition disturbance model
1, experiment material and method:
(1) medicine
Oral liquid of the present invention;
Scopolamine hydrobromide injection, He Feng pharmaceutical factory, Shanghai, lot number: 0005017;
The piracetam tablet, Shijiazhuang pharmaceutical factory of Xinhua, lot number 000410.
(2) animal
Male Kunming strain mice, body weight 18-22g is provided by Department Of Medicine, Peking University's Animal House, and the quality certification number is 01-3049.Animal is at constant temperature (21-23 ℃), constant humidity (45-65%), and the receptacle in each 12 hours light and shade cycle is raised with cage with 5 mices of sex, feeds with pellet, freely drinks water.
(3) instrument
YYE50 mice diving tower instrument, instrument plant of Beijing Medical University produces;
Y type water labyrinth apparatus, instrument plant of Beijing Medical University produces.
(4) model and grouping administration
Male 72 of Kunming kind is divided into 6 groups at random, i.e. matched group, and model group, the administration group (0.6g/Kg, 1.2g/Kg, 2.4g/Kg).Administration group gastric infusion, matched group and model group give the normal saline of equivalent, carry out test of memory after 10 minutes, adopt diving tower method and water maze method test learning and memory of little mouse situation.
(5) diving tower method
Each group mice is put into respectively on the mice diving tower instrument, and voltage maintains 36V, and operation repetitive during training conformed earlier 3 minutes, the back energising, and after mice was shocked by electricity, majority was jumped onto diving tower, escaped electric shock.That jumps off is considered as wrong reaction, trains 5 minutes, writes down errors number in 5 minutes.Again test after 24 hours, the record mice jumps off the time (incubation period) for the first time, write down number of times (being errors number) under 5 minutes introskips, and as remembering index.
(6) water maze method
Water temperature in the lost case of mice Y type water is maintained 25-27 ℃, about 10 centimetres of the depth of water.Each group mice divided into groups respectively to put into water is lost trains, during training mice is put down gently upstream face to arrive at platform with it in 15 seconds be correct response Y type fork is fond of food that is not salty from the long arm end tail, mice is arrived at the repetition training again in 15 seconds of having a rest behind the platform, connects training 6 times.The record mice is swum out of time and correct response number of times from entry to arriving at platform.Its memory maintenance situation of test after 24 hours, situation is consolidated in the test memory after 48 hours.
2, experimental result:
Diving tower method experimental result---table 1:
| Group (g/Kg) | Training achievement | Performance of the test | |
| Errors number (n) | Incubation period (s) | Errors number (n) | |
| Normal control group model group administration group 0.6 1.2 2.4 piracetams 0.72 | ?2.38±1.76** ?14.0±7.06 ?9.71±4.12 ?10.29±5.87 ?7.64±3.48* ?8.60±4.03* | 243.08±89.55** 55.2±107.05 157.02±127.08* 158.21±122.25* 166.00±130.40* 170.57±124.55* | 0.8±0.95** 9.0±7.68 3.36±5.39* 3.33±3.09* 2.27±3.75* 2.53±2.93* |
*Compare P＜0.05 with model group,
*Compare P＜0.01 with model group
Diving tower method experimental result---table 2:
| Group (g/Kg) | First day correct response number of times | Second day correct response number of times | The 3rd day correct response number of times |
| Normal control group model group administration group 0.6 1.2 2.4 piracetams 0.72 | ??3.17±1.2** ??0.83±1.03 ??1.93±2.02 ??1.93±1.64* ??2.43±1.28* ??2.00±1.47* | ??5.17±0.94** ??1.17±1.34 ??2.4±0.97* ??2.75±1.60* ??3.23±1.17* ??2.92±1.68** | ??5.83±0.39** ??1.17±1.34 ??2.83±1.34* ??2.83±1.33* ??2.45±1.37* ??3.00±1.47** |
*Compare P＜0.05 with model group,
*Compare P＜0.01 with model group
Conclusion: obviously prolong the incubation period of oral liquid administration group of the present invention, and errors number reduces, and helps to improve the correct response number of times, shows the protective effect to memory function.
(2) in the external protective effect experiment of carrying out the pair cell damage
1, experiment material
Former rat neurocyte of being commissioned to train foster, active constituents of medicine of the present invention
2, experimental technique
Conventional inoculating cell, treat that its differentiation is stable after, add active constituents of medicine in advance, protect after 24 hours, adding neurocyte toxin makes it to take place apoptosis.Added after the damage agent 24 hours, and detected the survival rate of cell with mtt assay.
3, result and discussion
Protective effect experimental result---table 3:
Group OD (X ± sd)
Normal control group 1.091**
Model group 0.687
Granule 0.6 0.765* of the present invention
1.2?????????????0.867*
2.4?????????????0.898*
Conclusion: three dosage groups of the present invention all have protective effect to neural cell injury, help hypermnesis.
The raw material of medicine of the present invention is formed and is had document now and all have different; and on theory of Chinese medical science; taken into account waking up the patient from unconsciousness by dissipating phlegm, QI invigorating the kidney invigorating, activating blood circulation to dissipate blood stasis; checking clinically and the experimentation on the pharmacology show; the intelligence disappearance that described medicine causes brain injury has significantly slows down and protective effect, and helps hypermnesis, and zoopery shows; anti senile dementia drug of the present invention has no side effect, and is used for the treatment of senile dementia and has fabulous curative effect.Clinical treatment 100 examples, produce effects 43 examples, effective 13 examples are cured 25 examples, total effective rate 81%.
The specific embodiment:
Embodiment 1:
The thing decoction pieces of getting it filled: Radix Paeoniae Alba 100g, Radix Ginseng 50g, Radix Angelicae Sinensis 350g and Radix Glycyrrhizae 150g, add the 6kg distilled water, decoct after 2 hours, inclining decoction liquor, adds the 6kg distilled water again, decocts 2 hours, after twice decoction liquor merging, under 65 ℃, thin film evaporation is to 1/3 of original volume, use filter cloth (200 order) to filter, obtain containing extraction of active ingredients liquid 3.75kg, add 450g sucrose, add 8 liters of waters for injection again, mix homogeneously, fill promptly get oral liquid.
Embodiment 2:
The thing decoction pieces of getting it filled: Radix Paeoniae Alba 200g, Radix Ginseng 150g, Radix Angelicae Sinensis 100g, Radix Glycyrrhizae 100g, Rhizoma Pinelliae 100g, Poria 400g, Rhizoma Acori Graminei 50g, Radix Curcumae 50g and Rhizoma Arisaematis 150g, add the 13kg distilled water, decoct after 3 hours, inclining decoction liquor, and under 50 ℃, thin film evaporation is to 1/2 of original volume, use filter cloth (200 order) to filter, obtain containing extraction of active ingredients liquid, continue it is concentrated, to density be 1.3g/cm
3Thick paste, add sucrose 3.2kg, granulate, drying, packing promptly gets granule.
Embodiment 3:
The thing decoction pieces of getting it filled: Radix Paeoniae Alba 400g, Radix Ginseng 200g, Radix Angelicae Sinensis 50g, Radix Glycyrrhizae 350g, Radix Bupleuri 150g, Semen Ziziphi Spinosae 400g and Massa Medicata Fermentata 400g, add the 39kg distilled water, decoct after 3 hours, inclining decoction liquor, adds the 39kg distilled water again, decocted 1 hour, inclining decoction liquor, continues to add the 39kg distilled water, decocts after 1 hour, three decoction liquor are merged, under 55 ℃, thin film evaporation uses filter cloth (200 order) to filter to 1/3 of original volume, obtain containing extraction of active ingredients liquid, its concentrate drying is pulverized in continuation, sieves, encapsulated, promptly get capsule.
Embodiment 4:
The thing decoction pieces of getting it filled: Radix Paeoniae Alba 400g, Radix Ginseng 300g, Radix Angelicae Sinensis 400g, Radix Glycyrrhizae 200g, Rhizoma Pinelliae 50g, Poria 150g, Rhizoma Acori Graminei 50g, Radix Curcumae 350g, Rhizoma Arisaematis 100g, Radix Bupleuri 50g, Semen Ziziphi Spinosae 50g and Massa Medicata Fermentata 150g, add the 22.5kg distilled water, decoct after 3 hours, incline and decoction liquor, add the 22.5kg distilled water again, decocted 3 hours, incline and decoction liquor, continue to add the 22.5kg distilled water, decoct after 3 hours, three decoction liquor are merged, under 60 ℃, thin film evaporation uses filter cloth (200 order) to filter to 1/3 of original volume, obtains containing extraction of active ingredients liquid 13.95kg, add 280g sucrose, add 27.9 liters of waters for injection again, mix homogeneously, fill promptly gets oral liquid.
Embodiment 5:
The thing decoction pieces of getting it filled: Radix Paeoniae Alba 400g, Radix Ginseng 400g, Radix Angelicae Sinensis 400g, Radix Glycyrrhizae 200g, Rhizoma Pinelliae 100g, Poria 400g, Rhizoma Acori Graminei 100g, Radix Curcumae 400g, Rhizoma Arisaematis 200g, Radix Bupleuri 100g, Semen Ziziphi Spinosae 100g and Massa Medicata Fermentata 200g, add the 30.0kg distilled water, decoct after 2 hours, inclining decoction liquor, adds the 30.0kg distilled water again, decocted 2 hours, inclining decoction liquor, continues to add the 30.0kg distilled water, decocts after 1 hour, three decoction liquor are merged, under 65 ℃, thin film evaporation uses filter cloth (200 order) to filter to 1/3 of original volume, obtain containing extraction of active ingredients liquid 20.7kg, filter, add 40kg water for injection, 70 ℃ of heating for dissolving, add the 6kg activated carbon, be incubated 30 minutes, filter fill, 100 ℃ of flowing steam sterilizations 15 minutes promptly get injection.
Embodiment 6:
The thing decoction pieces of getting it filled: Radix Paeoniae Alba 300g, Radix Ginseng 250g, Radix Angelicae Sinensis 200g, Radix Glycyrrhizae 200g, Rhizoma Pinelliae 80g, Poria 350g, Rhizoma Acori Graminei 70g, Radix Curcumae 200g, Rhizoma Arisaematis 100g, Radix Bupleuri 10g, Semen Ziziphi Spinosae 100g and Massa Medicata Fermentata 20g, add the 19.0kg distilled water, decoct after 3 hours, inclining decoction liquor, add the 19.0kg distilled water again, decocted 1 hour, and three decoction liquor were merged, under 65 ℃, thin film evaporation is to 1/4 of original volume, use filter cloth (200 order) to filter, obtain containing extraction of active ingredients liquid, continue its concentrate drying, pulverize, sieve, add the 1.5g magnesium stearate, mix, tabletting, the bag film-coat, drying promptly gets tablet.
Claims (10)
1, a kind of anti senile dementia drug is characterized in that comprising the medicament that the raw material of following weight parts is made:
Radix Paeoniae Alba 1-40, Radix Ginseng 1-40, Radix Angelicae Sinensis 1-40, Radix Glycyrrhizae 1-40.
2, anti senile dementia drug according to claim 1 is characterized in that described medicine also comprises the raw material of following weight parts:
Rhizoma Pinelliae 1-40, Poria 1-40, Rhizoma Acori Graminei 1-40, Radix Curcumae 1-40, Rhizoma Arisaematis 1-40.
3, anti senile dementia drug according to claim 1 and 2 is characterized in that described medicine also comprises the raw material of following weight parts:
Radix Bupleuri 1-40, Semen Ziziphi Spinosae 1-40, Massa Medicata Fermentata 1-40.
4, anti senile dementia drug according to claim 3 is characterized in that described medicine is the medicament of being made by the raw material of following weight parts:
Radix Paeoniae Alba 1-40, Radix Ginseng 1-40, Radix Angelicae Sinensis 1-40, Radix Glycyrrhizae 1-20,
Rhizoma Pinelliae 1-10, Poria 1-40, Rhizoma Acori Graminei 1-10, Radix Curcumae 1-40, Rhizoma Arisaematis 1-20,
Radix Bupleuri 1-10, Semen Ziziphi Spinosae 1-10, Massa Medicata Fermentata 1-20.
5, anti senile dementia drug according to claim 4 is characterized in that described medicine is the medicament of being made by the raw material of following weight parts:
The Radix Paeoniae Alba 40, Radix Ginseng 40, Radix Angelicae Sinensis 40, Radix Glycyrrhizae 20,
The Rhizoma Pinelliae 10, Poria 40, Rhizoma Acori Graminei 10, Radix Curcumae 40, Rhizoma Arisaematis 20,
Radix Bupleuri 10, Semen Ziziphi Spinosae 10, Massa Medicata Fermentata 20.
6,, it is characterized in that described medicine is that the method that adopts water to carry obtains the medicine that effective ingredient or Chinese medicine concocting method obtain according to the described anti senile dementia drug of claim 1-5.
7,, it is characterized in that said medicament is a said dosage form on oral liquid, capsule, tablet, pill, powder, extractum, granule, injection or other any pharmaceuticss according to claim 1,2 or 3 described anti senile dementia drugs.
8, the preparation method of any one described anti senile dementia drug of claim 1-6, the extraction and the medicaments preparation that comprise described active constituents of medicine, it is characterized in that, the extracting method of described active constituents of medicine is: the crude drug decoction pieces preparation of various medicines is mixed, the distilled water that adds 1-40 times of weight, decoct each 1-3 hour 1-3 time; Each time decoction liquor 50-70 ℃ of following thin film evaporation, is concentrated to the 1/2-1/4 of original volume after merging, and filters, and obtains the active component of medicine.
9, the preparation method of anti senile dementia drug according to claim 8 is characterized in that, in the described active constituents of medicine extracting method, after the medicine decoction pieces mixes, adds the distilled water of 10 times of weight, decocts 3 times, and each time time was respectively 2,2,1 hours.
10, the purposes of any one described anti senile dementia drug of claim 1-7 on preparation treatment and prevention medicine for senile dementia.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940676A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating cardia-cerebrovascular diseases |
| CN103404673A (en) * | 2013-08-28 | 2013-11-27 | 北京绿源求证科技发展有限责任公司 | Food brain-nourishing tee granule |
| CN105833183A (en) * | 2016-05-05 | 2016-08-10 | 宋云飞 | Drug for treating dementia |
| CN108210818A (en) * | 2018-04-16 | 2018-06-29 | 成都中医药大学 | A kind of pharmaceutical composition for preventing neurodegenerative disease and its preparation method and application |
| CN113476575A (en) * | 2021-07-28 | 2021-10-08 | 杜扬 | Traditional Chinese medicine composition for treating Alzheimer disease and preparation method thereof |
| CN114432418A (en) * | 2022-02-28 | 2022-05-06 | 福建金兰厚普生物科技有限公司 | Traditional Chinese medicine composition for treating Alzheimer's disease and application thereof |
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2003
- 2003-01-24 CN CNB031024653A patent/CN100368007C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940676A (en) * | 2012-10-31 | 2013-02-27 | 成都医路康医学技术服务有限公司 | Medicine composition for treating cardia-cerebrovascular diseases |
| CN102940676B (en) * | 2012-10-31 | 2014-05-14 | 成都医路康医学技术服务有限公司 | Medicine composition for treating cardia-cerebrovascular diseases |
| CN103404673A (en) * | 2013-08-28 | 2013-11-27 | 北京绿源求证科技发展有限责任公司 | Food brain-nourishing tee granule |
| CN105833183A (en) * | 2016-05-05 | 2016-08-10 | 宋云飞 | Drug for treating dementia |
| CN108210818A (en) * | 2018-04-16 | 2018-06-29 | 成都中医药大学 | A kind of pharmaceutical composition for preventing neurodegenerative disease and its preparation method and application |
| CN113476575A (en) * | 2021-07-28 | 2021-10-08 | 杜扬 | Traditional Chinese medicine composition for treating Alzheimer disease and preparation method thereof |
| CN114432418A (en) * | 2022-02-28 | 2022-05-06 | 福建金兰厚普生物科技有限公司 | Traditional Chinese medicine composition for treating Alzheimer's disease and application thereof |
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| Publication number | Publication date |
|---|---|
| CN100368007C (en) | 2008-02-13 |
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