CN102274405A - Medicament for treating sequelae of cerebral concussion - Google Patents
Medicament for treating sequelae of cerebral concussion Download PDFInfo
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- CN102274405A CN102274405A CN2011102258245A CN201110225824A CN102274405A CN 102274405 A CN102274405 A CN 102274405A CN 2011102258245 A CN2011102258245 A CN 2011102258245A CN 201110225824 A CN201110225824 A CN 201110225824A CN 102274405 A CN102274405 A CN 102274405A
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Abstract
The invention relates to a medicament for treating sequelae of cerebral concussion, and the medicament comprises earthworm, frankincense, radix salviae miltiorrhizae, myrrh, red paeony root, fossilizid, oyster shell, safflower, Szechuan lovage rhizome, largetrifoliolious bugbane rhizome, Chinese thorowax root, green tangerine peel, dendrobium, magnetite, gambir plant, scorpion, nutgrass galingale rhizome, chrysanthemum and liquoric root, and is prepared by adding water for decoction for getting decoction, concentrating, then adding conventional auxiliary materials, adding purified water till the content of crude medicament is 1g/ml, filling and sterilizing for preparing an oral liquid preparation. The medicament has the effects of regulating qi-flowing, promoting blood circulation, inducing menstruation and relieving pain; when the medicament is used for treating the sequelae of the cerebral concussion, the medicament not only has fast onset of action, but also has the effects of rapidly reliving pain, regulating qi, promoting blood circulation, removing blood stasis, stopping the pain, eliminating toxic materials and eliminating stagnation; and the cure rate for treating the sequelae of the cerebral concussion is high, the recurrence rate is low, the medicament can treat both manifestation and root cause of the disease without the sequelae, a patient has no suffering during the treatment period, and the clinical observation shows that the effective rate is 100%.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cerebral concussion sequela, particularly a kind of is the Chinese medicine of the treatment of crude drug preparation with Chinese medicine.
Background technology
Cerebral concussion is because of of short duration dysfunction appears in reticular formation of brain stem after the wound, makes brain cortex that a kind of disease that suppresses take place.Be characterized in the disturbance of consciousness of short time, have after waking up and of short duration retrogradely forget, and do not have the sign of organic damage.
The cerebral concussion sequela patient mostly occurs being outstanding symptom with headache, pain character is distending pain, dull pain, deflation pain or the sample pain of beating, headache can because of require mental skill, read, how noisy vibrations, special odor, air pollution, people are, Nervous and Mental Factors increases the weight of, in addition often with insomnia, hypomnesis, absent minded, irritated, emotional, bradykinesia to external world, and dizzy, dizzy, hyperhidrosis, unable, nervous, out of breath, nauseating etc.
The traditional Chinese medical science thinks that cerebral concussion sequela is the damage of brain network, and clinical syndrome differentiation person should catch " stasis of blood " word earlier.A blood stagnant in cerebral venation syndrome person localized pain wherein, pain as being stabbed, pain ceaselessly, dizziness and distending sensation of the head, the time heavy when light, weight person's order of going into a coma closes syncope; There is petechia on purplish tongue or tongue limit, and hesitant pulse is unfavorable to be controlled, with blood circulation promoting and blood stasis dispelling.
At present, treat cerebral concussion sequela clinically, common multiselect piracetam, rotundine, oryzanol etc., adopt above-mentioned brain-strengthening tonic or medicine that cerebral concussion sequela is had certain help effect and curative effect, but exist curative effect not fully up to expectations, rehabilitation efficacy is not good, and sequela occurs repeatedly, is difficult to defectives such as thoroughly elimination.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of cerebral concussion sequela, this medicine regulating qi and activating blood, stasis-dispelling and pain-killing, dispersing pathogen accumulation, treatment cerebral concussion sequela cure rate height, relapse rate is low.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Pheretima 12---15 Olibanum 12---15
Radix Salviae Miltiorrhizae 12---15 Myrrha 8---10
Radix Paeoniae Rubra 12---15 Os Draconis 12---15
Concha Ostreae 12---15 Flos Carthami 10---12
Rhizoma Chuanxiong 12---15 Rhizoma Cimicifugae 10---12
Radix Bupleuri 10---12 Pericarpium Citri Reticulatae Viride 15---20
Herba Dendrobii 10---15 Magnetitum 18---20
Ramulus Uncariae Cum Uncis 12---15 Scorpio 10---12
Rhizoma Cyperi 10---12 Flos Chrysanthemi 10---12
Radix Glycyrrhizae 8---10.
The above-mentioned raw materials medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is an oral liquid.
The concrete preparation method of above-mentioned each component being made medicine of the present invention is:
With above-mentioned bulk drugs mix homogeneously, decoct with water 2-4 time, each 1-2 hour, collecting decoction, filter, filtrate is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, and cold preservation is left standstill, and gets supernatant liquid filtering, add conventional adjuvant in the filtrate, mixing, adding purified water is 1g/mL to containing the crude drug amount, oral liquid formulations is made in fill, sterilization.
Using method: oral, each 1, every 15mL, every day 3 times.
In the prescription of the present invention, Pheretima salty in the mouth cold in nature, heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging; The Olibanum regulating qi and activating blood, analgesic therapy chases after poison; The Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Myrrha promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin; Radix Paeoniae Rubra clots absorbing, pain relieving, removing heat from blood, detumescence; Os Draconis tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing; Concha Ostreae has convergence, calmness, detoxifcation, analgesic effect; The Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; The Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping; Rhizoma Cimicifugae is delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy; Radix Bupleuri is evacuated and is brought down a fever the yang invigorating soothing liver-QI; The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, removing food stagnancyization stagnate; The Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat; The Magnetitum suppressing the hyperactive liver and subsiding YANG, it is relieving convulsion to calm the nerves, hearing-improing and eyesight improving, helping inspiration to relieve asthma; Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; Scorpio endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; The Rhizoma Cyperi resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving; The heat clearing away of chrysanthemum powder forimproving wind, suppressing the hyperactive liver makes eye bright; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.More than all medicines share, regulating qi and activating blood, stasis-dispelling and pain-killing, dispersing pathogen accumulation is used for the treatment cure rate height of cerebral concussion sequela, relapse rate is low, no sequel does not have other Western medicine preparations to side reactions such as liver, renal damages, the drug resistance of antibiotic-free etc. yet.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 97 routine cerebral concussion sequela patients that the curative effect of medicine of the present invention is carried out clinical observation.
Diagnosis basis:
1. injury of head or indirect trauma history are arranged.
2. coma appears after hindering, and fidgety not peaceful, dizziness headache, diseases such as nausea and vomiting.
3. can determine damage location and degree in conjunction with medical history and health check-up situation, CT, magnetic resonance examination.
97 routine cases are divided into two groups at random, matched group 42 examples, and 55 examples are organized in treatment.According to the clinical scale standard, wherein, matched group mild or moderate case 12 examples, moderate case 21 examples, severe case 9 examples; Treatment group mild or moderate case 10 examples, moderate case 29 examples, severe case 16 examples.
Matched group is used the medicine piracetam always with doctor trained in Western medicine, and oral: each 0.8～1.6g (2～4), every day 3 times, 4～8 weeks were a course of treatment.Child's consumption reduces by half or gives 40mg/kg at every turn.After taking a course of treatment, maintenance dose reduces by half. and the treatment group adopts medicine of the present invention to treat, and is oral, and each 1, every 15mL, every day 3 times.
Criterion of therapeutical effect: according to disease of tcm diagnosis criterion of therapeutical effect, cure: conscious, transference cure or basic the disappearance can be recovered routine work; Take a turn for the better: conscious, doing well,improving, life is basic takes care of oneself or partial self-help; Do not heal: symptom does not have improvement.
Two groups of case treatment back curative effect comparative results see Table 1.
Clinical experiment is the result prove, drug effect of the present invention obviously is better than matched group, do not see any untoward reaction.
The specific embodiment
Embodiment 1
Get Pheretima 1.3Kg, Olibanum 1.3Kg, Radix Salviae Miltiorrhizae 1.4Kg, Myrrha 0.9Kg, Radix Paeoniae Rubra 1.3Kg, Os Draconis 1.3Kg, Concha Ostreae 1.3Kg, Flos Carthami 1.1Kg, Rhizoma Chuanxiong 1.4Kg, Rhizoma Cimicifugae 1.1Kg, Radix Bupleuri 1.1Kg, Pericarpium Citri Reticulatae Viride 1.9Kg, Herba Dendrobii 1.3Kg, Magnetitum 1.9Kg, Ramulus Uncariae Cum Uncis 1.3Kg, Scorpio 1.1Kg, Rhizoma Cyperi 1.1Kg, Flos Chrysanthemi 1.1Kg, Radix Glycyrrhizae 0.9Kg, clean with clear water, add decocting in water 3 times, each 1 hour, collecting decoction filters, and is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, cold preservation is left standstill, and gets supernatant liquid filtering, adds conventional adjuvant in the filtrate, mixing, adding purified water is 1g/mL to containing the crude drug amount, fill, oral liquid formulations is made in sterilization.
Embodiment 1
Get Pheretima 1.5Kg, Olibanum 1.5 Kg, Radix Salviae Miltiorrhizae 1.5 Kg, Myrrha 1.0 Kg, Radix Paeoniae Rubra 1.5 Kg, Os Draconis 1.5 Kg, Concha Ostreae 1.5 Kg, Flos Carthami 1.2 Kg, Rhizoma Chuanxiong 1.5 Kg, Rhizoma Cimicifugae 1.2 Kg, Radix Bupleuri 1.2 Kg, Pericarpium Citri Reticulatae Viride 2.0 Kg, Herba Dendrobii 1.5 Kg, Magnetitum 2.0 Kg, Ramulus Uncariae Cum Uncis 1.5 Kg, Scorpio 1.2 Kg, Rhizoma Cyperi 1.2 Kg, Flos Chrysanthemi 1.2 Kg, Radix Glycyrrhizae 1.0Kg, clean with clear water, add decocting in water 3 times, each 1 hour, collecting decoction filters, and is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, cold preservation is left standstill, and gets supernatant liquid filtering, adds conventional adjuvant in the filtrate, mixing, adding purified water is 1g/mL to containing the crude drug amount, fill, oral liquid formulations is made in sterilization.
Claims (3)
1. medicine for the treatment of cerebral concussion sequela is that crude drug prepares by the Chinese medicine of following portions by weight:
Pheretima 12---15 Olibanum 12---15
Radix Salviae Miltiorrhizae 12---15 Myrrha 8---10
Radix Paeoniae Rubra 12---15 Os Draconis 12---15
Concha Ostreae 12---15 Flos Carthami 10---12
Rhizoma Chuanxiong 12---15 Rhizoma Cimicifugae 10---12
Radix Bupleuri 10---12 Pericarpium Citri Reticulatae Viride 15---20
Herba Dendrobii 10---15 Magnetitum 18---20
Ramulus Uncariae Cum Uncis 12---15 Scorpio 10---12
Rhizoma Cyperi 10---12 Flos Chrysanthemi 10---12
Radix Glycyrrhizae 8---10.
2. the medicine of treatment cerebral concussion sequela according to claim 1 is characterized in that described crude drug is made oral liquid.
3. according to the preparation method of the medicine of the described treatment cerebral concussion sequela of claim 2, be, decoct with water 2-4 time the crude drug mix homogeneously of above-mentioned parts by weight, each 1-2 hour, collecting decoction filters, and filtrate is condensed into the clear paste of 70 ℃ of relative density 1.15-1.18, cold preservation is left standstill, get supernatant liquid filtering, add conventional adjuvant, mixing in the filtrate, adding purified water is 1g/mL to containing the crude drug amount, and oral liquid formulations is made in fill, sterilization.
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| CN2011102258245A CN102274405A (en) | 2011-08-08 | 2011-08-08 | Medicament for treating sequelae of cerebral concussion |
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| CN2011102258245A CN102274405A (en) | 2011-08-08 | 2011-08-08 | Medicament for treating sequelae of cerebral concussion |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168724A (en) * | 2015-10-22 | 2015-12-23 | 孔德华 | Traditional Chinese medicinal preparation for treating post-traumatic brain syndrome and preparation method thereof |
| CN105250669A (en) * | 2015-10-12 | 2016-01-20 | 孟庆国 | Traditional Chinese medicine composition for treating cerebral concussion sequelae |
| CN105663540A (en) * | 2016-02-02 | 2016-06-15 | 李朝晖 | Traditional Chinese medicine composition for treating cerebral concussion sequelae |
| CN106924676A (en) * | 2017-05-02 | 2017-07-07 | 徐士杰 | It is a kind of to treat medicine of postconcussion syndrome and preparation method thereof |
Citations (2)
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| CN1911346A (en) * | 2006-08-18 | 2007-02-14 | 芮晨宸 | Medicine for treating headache contg. radix bupleuri, ligusticum wallichii, root of Dahurain angelica, Chinese angelica and mother chrysanthemum |
| CN1943673A (en) * | 2005-10-09 | 2007-04-11 | 林朝文 | Sedation brain refreshing liquid |
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2011
- 2011-08-08 CN CN2011102258245A patent/CN102274405A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943673A (en) * | 2005-10-09 | 2007-04-11 | 林朝文 | Sedation brain refreshing liquid |
| CN1911346A (en) * | 2006-08-18 | 2007-02-14 | 芮晨宸 | Medicine for treating headache contg. radix bupleuri, ligusticum wallichii, root of Dahurain angelica, Chinese angelica and mother chrysanthemum |
Non-Patent Citations (2)
| Title |
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| 司玫: "补阳还五汤的临床新用途", 《时珍国医国药》, vol. 15, no. 8, 31 August 2004 (2004-08-31), pages 530 - 4 * |
| 薛平定: "通脑逐瘀汤治疗脑震荡后遗症", 《四川中医》, vol. 2, no. 5, 31 May 1984 (1984-05-31), pages 300 - 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250669A (en) * | 2015-10-12 | 2016-01-20 | 孟庆国 | Traditional Chinese medicine composition for treating cerebral concussion sequelae |
| CN105168724A (en) * | 2015-10-22 | 2015-12-23 | 孔德华 | Traditional Chinese medicinal preparation for treating post-traumatic brain syndrome and preparation method thereof |
| CN105663540A (en) * | 2016-02-02 | 2016-06-15 | 李朝晖 | Traditional Chinese medicine composition for treating cerebral concussion sequelae |
| CN106924676A (en) * | 2017-05-02 | 2017-07-07 | 徐士杰 | It is a kind of to treat medicine of postconcussion syndrome and preparation method thereof |
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Application publication date: 20111214 |