CN103405660A - Compound medicine for treating headache - Google Patents
Compound medicine for treating headache Download PDFInfo
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- CN103405660A CN103405660A CN2013103442004A CN201310344200A CN103405660A CN 103405660 A CN103405660 A CN 103405660A CN 2013103442004 A CN2013103442004 A CN 2013103442004A CN 201310344200 A CN201310344200 A CN 201310344200A CN 103405660 A CN103405660 A CN 103405660A
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- 239000003814 drug Substances 0.000 title claims abstract description 34
- 206010019233 Headaches Diseases 0.000 title claims abstract description 19
- 231100000869 headache Toxicity 0.000 title claims abstract description 18
- 150000001875 compounds Chemical class 0.000 title claims abstract description 11
- 229930003451 Vitamin B1 Natural products 0.000 claims abstract description 10
- 229940079593 drug Drugs 0.000 claims abstract description 10
- 229960003495 thiamine Drugs 0.000 claims abstract description 10
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 10
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 10
- 235000010374 vitamin B1 Nutrition 0.000 claims abstract description 10
- 239000002775 capsule Substances 0.000 claims abstract description 7
- 241000305492 Gastrodia Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 abstract description 18
- 230000036407 pain Effects 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 13
- 239000000203 mixture Substances 0.000 abstract description 10
- 238000001035 drying Methods 0.000 abstract description 6
- 239000000843 powder Substances 0.000 abstract description 5
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 206010067482 No adverse event Diseases 0.000 abstract description 2
- 241000758794 Asarum Species 0.000 abstract 1
- 241000305491 Gastrodia elata Species 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 240000004370 Pastinaca sativa Species 0.000 abstract 1
- 235000017769 Pastinaca sativa subsp sativa Nutrition 0.000 abstract 1
- 241000951473 Schizonepeta Species 0.000 abstract 1
- 241000157373 Uncaria rhynchophylla Species 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003529 diazepam Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 5
- 239000003390 Chinese drug Substances 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 229940071462 oralone Drugs 0.000 description 4
- 239000012535 impurity Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 244000257039 Duranta repens Species 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 206010029240 Neuritis Diseases 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000013219 diaphoresis Diseases 0.000 description 2
- 230000035620 dolor Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 206010036105 Polyneuropathy Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001670 myorelaxant effect Effects 0.000 description 1
- 208000028412 nervous system injury Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 208000019629 polyneuritis Diseases 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides compound medicine for treating headache. The compound medicine is prepared through the steps as follows: uniformly mixing the crude drugs in parts by weight: 10-30 parts of ligusticum wallichii, 10-30 parts of schizonepeta, 10-30 parts of Chinese parsnip root, 5-20 parts of notopterygium root, 3-20 parts of radix angelicae, 3-15 parts of asarum, 10-20 parts of radices ligustici sinensis, 3-20 parts of gastrodia elata, 10-20 parts of uncaria rhynchophylla, 10-20 parts of rhizoma anemarrhenae and 10-30 parts of radix scutellariae, and extracting TCM active components; decocting the mixture with water for 3 times taking 0.5-1 hour every time,combining the three-time decoction, filtering, and concentrating to form the thick paste with the temperature of 60 DEG C and the relative density of 1.25-1.3, drying the thick paste at the temperature of 50-60 DEG C, and crushing the thick paste into powder with 100 meshes; adding the crude drugs of 0.25-5 parts of diazepam and 0.05-1 part of vitamin B1 by weight to the extracted TCM active components, uniformly mixing and putting the mixture into a capsule, and performing sterilization to obtain the capsule product. The compound medicine provided by the invention has the functions of expelling wind chill and stopping pain, and is short in course of treatment of acute and chronic headache, and effective in treatment. Through clinical observation of curative effects of 50 patients, 45 patients are cured, the illness conditions of 4 patients are improved, one patient is not cured due to ineffectiveness of the compound medicine, the effective rate is 98%, and the cure rate is 90%. During medication, no adverse reaction exists.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of headache, particularly relate to a kind of compound medicine of the treatment headache of compatibility Chinese medicine in Western medicine.
Background technology
The headache degree has gently to be had heavily, and it is short that pain time has length to have.The pain form is varied, common distending pain, vexed pain, tears sample pain, electric shock sample pain, prickling-like pain, and part is with vascular pulsation sense and the sense of head lock ring, and feel sick, vomiting, the symptom such as dizzy.The Secondary cases headache also can be with other system disease symptoms or sign, and often with heating, vascular lesion is often accompanied the neurologic impairment symptoms such as hemiplegia, aphasia etc. as infectious disease.Headache produces different harm according to degree, is in a bad way and can makes the patient lose the live and work ability.Traditional therapy is single medication, or single antiinflammatory, pain relieving, and temporary transient relief of symptoms, but can not prolongedly cure.
Summary of the invention
The purpose of this invention is to provide the compound medicine that a kind of curative effect is fast, the treatment of short treating period is had a headache.
Medicine of the present invention is that the crude drug by following ratio of weight and number prepares:
Rhizoma Chuanxiong 10-30 Herba Schizonepetae 10-30
Radix Saposhnikoviae 10-30 Rhizoma Et Radix Notopterygii 5-20
Radix Angelicae Dahuricae 3-20 Herba Asari 3-15
Rhizoma Ligustici 10-20 Rhizoma Gastrodiae 3-20
Ramulus Uncariae Cum Uncis 10-20 Radix Scutellariae 10-30
Rhizoma Anemarrhenae 10-20 stabilizes 0.25-5
Vitamin B1 0.05-1.
The preferred weight umber of described each crude drug is:
Rhizoma Chuanxiong 20 Herba Schizonepetae 20
Radix Saposhnikoviae 20 Rhizoma Et Radix Notopterygiis 10
The Radix Angelicae Dahuricae 15 Herba Asaris 8
Rhizoma Ligustici 15 Rhizoma Gastrodiaes 12
Ramulus Uncariae Cum Uncis 12 Radix Scutellariaes 20
The Rhizoma Anemarrhenae 12 stable 2
Vitamin B1 0.5.
By above-mentioned various Chinese medicine according to described ratio of weight and number mix homogeneously after, extract the active component of Chinese medicine: decoct with water 3 times, each 0.5～1 hour, merge 3 times decocting liquid, filter, be condensed into 60 ℃ of relative densities and be 1.25～1.3 thick paste, after 50～60 ℃ of dryings, be crushed to 100 purpose medicated powder; In the active Chinese drug component component of extracting, add during stable, the vitamin B1 mix homogeneously of described parts by weight incapsulate, sterilization makes the capsule product.Every heavy 1.5 grams of this product.
In prescription of the present invention, the Rhizoma Chuanxiong acrid in the mouth, warm in nature, hot can faling apart, Wen Nengtong, have blood-activating and qi-promoting, the effect of wind-expelling pain-stopping; The Herba Schizonepetae acrid in the mouth, slightly warm in nature, energy relieving the exterior syndrome by diaphoresis, dispersing wind and cold, refresh oneself; The Radix Saposhnikoviae acrid-sweet flavor, slightly warm in nature, have the effect of Pulvis Diaphoreticus wind and cold dehumidifying; Rhizoma Et Radix Notopterygii acrid in the mouth hardship, warm in nature, relieving the exterior syndrome by diaphoresis is arranged, dispersing wind and cold, the effect of dehumidifying; Radix Angelicae Dahuricae acrid in the mouth, warm in nature, can deliver dispersing wind and cold, be apt to control the neck effect that wind and cold causes; The Herba Asari acrid in the mouth, warm in nature, the wind and cold of the shaoyang channel of faling apart, but and pain relieving; The Rhizoma Ligustici acrid in the mouth, warm in nature, have and control the effect of having a pain in top, head mountain peak; The Rhizoma Gastrodiae sweet in the mouth, property is flat, and the flat liver-wind that puts out is arranged, and removes the effect of spasm; The Ramulus Uncariae Cum Uncis sweet in the mouth, cold nature, have the peaceful effect of putting out liver-wind of heat clearing away; The Radix Scutellariae bitter in the mouth, cold in nature, the effect of heat clearing and damp drying is arranged; Rhizoma Anemarrhenae bitter in the mouth, cold in nature, the nourshing Yin and drynsessmoistening prescription effect of heat clearing away is arranged; Stable this product has stable, calmness, hypnosis, anxiety, convulsion, epilepsy and maincenter myorelaxant effects; Vitamin B1 is mainly used in polyneuritis, peripheral neuritis, central nervous system injury, malnutrition etc.
For further investigating the clinical efficacy of Drug therapy headache of the present invention, select 50 routine headaches to carry out clinical observation on the therapeutic effect.
Clinical data:
Select outpatient's 50 examples, wherein male 30 examples, female's 20 examples, the course of disease 3 months～1 year, 0～50 years old age.
The tcm diagnosis standard
Clinical syndrome diagnostic criterion according to nineteen ninety-five State Administration of Traditional Chinese Medicine's People's Republic of China's Chinese medicine industry standard " disease of tcm Standardization of diagnosis and curative effect " of promulgating: volume, temporo, orbital part that headache shows as a side (being individually both sides) have an intense pain, headache can be twinge, distending pain, with the characteristics of the corresponding pattern of syndrome such as uncomfortable in chest, fever with chills, breast wrist painful abdominal mass be vexed, the tongue arteries and veins is also different with symptom.
Therapeutic Method: oral medicine of the present invention, oral one time 5, three times on the one, one after each meal.10 days is a course for the treatment of, takes 2 courses for the treatment of.
Traditional Chinese medical science disease criterion of therapeutical effect
" new Chinese medicine guideline of clinical investigations " with reference to Ministry of Health of the People's Republic of China's nineteen ninety-five issue:
Clinical recovery: headache and simultaneous phenomenon disappear more than 6 months without recurrence;
Produce effects: pain intensity alleviates 2 grades, and simultaneous phenomenon alleviates, or attack times or durante dolors reduce more than 2/3;
Effectively: pain intensity alleviates 1 grade, or the prolongation of outbreak interval, or the headache persistent period shortens less than 2/3;
Invalid: pain intensity alleviates 1 grade of less than, or durante dolors shortens less than 1/3, or pain increases the weight of, and the persistent period extends.
Therapeutic outcome:
2 courses for the treatment of of 50 routine patient's oral administration Drug therapy of the present invention, cure 45 examples, take a turn for the better 4 examples, invalid 1 example, effective percentage 98%, cure rate 90%.Period in a medicine, have no adverse reaction.
The specific embodiment
Embodiment 1
Take and remove impurity, after the Rhizoma Chuanxiong 10g cleaned up, Herba Schizonepetae 10g, Radix Saposhnikoviae 10g, Rhizoma Et Radix Notopterygii 5g, Radix Angelicae Dahuricae 3g, Herba Asari 3g, Rhizoma Ligustici 10g, Rhizoma Gastrodiae 3g, Ramulus Uncariae Cum Uncis 10g, Rhizoma Anemarrhenae 10g, Radix Scutellariae 10g mix homogeneously, extract the active component of Chinese medicine: decoct with water 3 times, each 0.5～1 hour, merge 3 times decocting liquid, filter, be condensed into 60 ℃ of relative densities and be 1.25～1.3 thick paste, after 50～60 ℃ of dryings, be crushed to 100 purpose medicated powder; In the active Chinese drug component component of extracting, add during stable 0.25g, vitamin B1 0.05g mix homogeneously incapsulate, sterilization makes the capsule product.Every heavy 1.5 grams of this product.
Using method: oral one time 5, three times on the one, one after each meal.
Embodiment 2
Take and remove impurity, after the Rhizoma Chuanxiong 20g cleaned up, Herba Schizonepetae 20g, Radix Saposhnikoviae 20g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Dahuricae 15g, Herba Asari 8g, Rhizoma Ligustici 15g, Rhizoma Gastrodiae 12g, Ramulus Uncariae Cum Uncis 12g, Rhizoma Anemarrhenae 12g, Radix Scutellariae 20g mix homogeneously, extract the active component of Chinese medicine: decoct with water 3 times, each 0.5～1 hour, merge 3 times decocting liquid, filter, be condensed into 60 ℃ of relative densities and be 1.25～1.3 thick paste, after 50～60 ℃ of dryings, be crushed to 100 purpose medicated powder; In the active Chinese drug component component of extracting, add during stable 2g, vitamin B1 0.5g mix homogeneously incapsulate, sterilization makes the capsule product.Every heavy 1.5 grams of this product.
Using method: oral one time 5, three times on the one, one after each meal.
Embodiment 3
Take and remove impurity, after the Rhizoma Chuanxiong 30g cleaned up, Herba Schizonepetae 30g, Radix Saposhnikoviae 30g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Dahuricae 20g, Herba Asari 15g, Rhizoma Ligustici 20g, Rhizoma Gastrodiae 20g, Ramulus Uncariae Cum Uncis 20g, Rhizoma Anemarrhenae 20g, Radix Scutellariae 30g mix homogeneously, extract the active component of Chinese medicine: decoct with water 3 times, each 0.5～1 hour, merge 3 times decocting liquid, filter, be condensed into 60 ℃ of relative densities and be 1.25～1.3 thick paste, after 50～60 ℃ of dryings, be crushed to 100 purpose medicated powder; In the active Chinese drug component component of extracting, add during stable 5g, vitamin B1 1g mix homogeneously incapsulate, sterilization makes the capsule product.Every heavy 1.5 grams of this product.
Using method: oral one time 5, three times on the one, one after each meal.
Claims (3)
1. compound medicine for the treatment of headache is that the crude drug by following ratio of weight and number prepares:
Rhizoma Chuanxiong 10-30 Herba Schizonepetae 10-30
Radix Saposhnikoviae 10-30 Rhizoma Et Radix Notopterygii 5-20
Radix Angelicae Dahuricae 3-20 Herba Asari 3-15
Rhizoma Ligustici 10-20 Rhizoma Gastrodiae 3-20
Ramulus Uncariae Cum Uncis 10-20 Radix Scutellariae 10-30
Rhizoma Anemarrhenae 10-20 stabilizes 0.25-5
Vitamin B1 0.05-1.
2. the compound medicine for the treatment of according to claim 1 headache, wherein the parts by weight of each crude drug are:
Rhizoma Chuanxiong 20 Herba Schizonepetae 20
Radix Saposhnikoviae 20 Rhizoma Et Radix Notopterygiis 10
The Radix Angelicae Dahuricae 15 Herba Asaris 8
Rhizoma Ligustici 15 Rhizoma Gastrodiaes 12
Ramulus Uncariae Cum Uncis 12 Radix Scutellariaes 20
The Rhizoma Anemarrhenae 12 stable 2
Vitamin B1 0.5.
3. the compound medicine of headache according to claim 1 and 2, is characterized in that described medicine is made to capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310344200.4A CN103405660B (en) | 2013-08-09 | 2013-08-09 | Compound medicine for treating headache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310344200.4A CN103405660B (en) | 2013-08-09 | 2013-08-09 | Compound medicine for treating headache |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103405660A true CN103405660A (en) | 2013-11-27 |
| CN103405660B CN103405660B (en) | 2015-05-20 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310344200.4A Active CN103405660B (en) | 2013-08-09 | 2013-08-09 | Compound medicine for treating headache |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103405660B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030853A (en) * | 2017-12-01 | 2018-05-15 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine for treating chill wet type headache |
| CN108578585A (en) * | 2018-05-31 | 2018-09-28 | 潘艳 | A kind of traditional Chinese medicine pill and preparation method thereof for treating tension headache |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160578A (en) * | 1997-02-27 | 1997-10-01 | 缪兴财 | Brain-nourishing Xiongshou bolus |
| CN1243745A (en) * | 1999-07-22 | 2000-02-09 | 蒋勤 | Chinese patent medicine for treating headache |
| CN101099763A (en) * | 2006-07-07 | 2008-01-09 | 张仁久 | Traditional Chinese medicine for treating headache |
| CN101112536A (en) * | 2007-08-17 | 2008-01-30 | 牟培新 | Oral Chinese traditional medicine composition for treating typhoid fever headache |
-
2013
- 2013-08-09 CN CN201310344200.4A patent/CN103405660B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160578A (en) * | 1997-02-27 | 1997-10-01 | 缪兴财 | Brain-nourishing Xiongshou bolus |
| CN1243745A (en) * | 1999-07-22 | 2000-02-09 | 蒋勤 | Chinese patent medicine for treating headache |
| CN101099763A (en) * | 2006-07-07 | 2008-01-09 | 张仁久 | Traditional Chinese medicine for treating headache |
| CN101112536A (en) * | 2007-08-17 | 2008-01-30 | 牟培新 | Oral Chinese traditional medicine composition for treating typhoid fever headache |
Non-Patent Citations (4)
| Title |
|---|
| 侯生芹: "通瘀定痛汤治疗偏头痛30例", 《实用中医药杂志》, vol. 25, no. 11, 30 November 2009 (2009-11-30), pages 743 * |
| 张世芳等: "安神剂的临床应用研究现状", 《医学综述》, vol. 14, no. 17, 30 September 2008 (2008-09-30), pages 2689 - 2691 * |
| 张洪斌: "头痛", 《山东中医杂志》, vol. 13, no. 10, 31 December 1994 (1994-12-31), pages 470 - 472 * |
| 朱萍等: "中西医结合治疗血管神经性头痛47例", 《河北中医》, vol. 23, no. 6, 31 December 2001 (2001-12-31), pages 458 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030853A (en) * | 2017-12-01 | 2018-05-15 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine for treating chill wet type headache |
| CN108578585A (en) * | 2018-05-31 | 2018-09-28 | 潘艳 | A kind of traditional Chinese medicine pill and preparation method thereof for treating tension headache |
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| Publication number | Publication date |
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| CN103405660B (en) | 2015-05-20 |
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Inventor after: Su Shaobo Inventor before: Zhao Junhai |
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| TR01 | Transfer of patent right |
Effective date of registration: 20151223 Address after: 048100, Yangcheng County, Shanxi City, Jincheng Province Water Town Village Ya rock bottom No. 74 Patentee after: SHANXI REALLY TECHNOLOGY CO., LTD. Address before: 031600, Shanxi City, Linfen province Hongdong County town of large ash East Village Patentee before: Zhao Junhai |