CN102133347B - Drug for treating neurogenic headache - Google Patents

Abstract

The invention discloses a drug for treating neurogenic headache, which consists of the following raw materials: 10-15 parts of ligusticum, 10-15 parts of fructus viticis, 8-12 parts of angelica, 10-15 parts of Szechuan lovage rhizome, 10-15 parts of red paeony root, 10-30 parts of angelica sinensis, 10-30 parts of salvia, 10-30 parts of poria with hostwood, 10-20 parts of uncaria, 10-20 parts of figwort, 8-15 parts of gastrodia elata, 5-10 parts of lumbricus, 10-15 parts of rhizoma corydalis, 10-30 parts of nacre and 3-5 parts of liquorice. The raw materials are boiled in water to obtain a decoction and the decoction is concentrated and dried to prepare an oral drug. The drug provided by the invention has the curative effects of expelling wind and removing cold, opening orifice and relieving pain, clearing heat and cooling blood, tonifying spleen and vital energy, clearing away heart-fire and relieving restlessness as well as nourishing blood and tranquilizing; and clinical experiments verify that the drug has a good curative effect for treating neurogenic headache and does not have any toxic and side effect.

Description

A kind of medicine of treating nervous headache

Technical field

The present invention relates to a kind of medicine, particularly a kind of medicine and process for preparing medicine thereof of treating nervous headache.

Background technology

Nervous headache mainly is meant tension headache, functional headache and angioneurotic headache, how to be caused by psychentonia, anger, and cardinal symptom is the vexed pain of the head of persistence, constriction, sense of heaviness, and the patient's private prosecution that has is that head has " lock ring " sense.Most patients is an amphicrania, is mostly two temporo sides, rear pillow part and head or full head.Headache character is dull pain, distending pain, constriction, feeling of numbness and the sense of band appearance lock ring.To moderate, seldom bitterly be unable to leave the bed or influence daily life by excuse for slightly for the intensity of headache.The patient who has can have persistence headache year in year out, the patient's who has symptom even can recall 10-20.Patient can have a headache all day, and the time of headache will be more than bitterly time not.Because factors such as excitement, anger, insomnia, anxiety or melancholy often make the headache aggravation.Some patient not only has the characteristics of tension headache, and also has the clinical manifestation of vascular headache, the two temporo side pulsatile headaches of main suit.This existing tension headache has the clinical manifestation of vascular headache again, is called the mixed type headache.Patient many with dizziness, irritated irritability, anxious, have palpitation, breathe hard, symptoms such as fear, tinnitus, insomnia and dreamful sleep, sore waist and aching in the waist and the back, Wry Neck, part patient rests the head on both sides or two temporo sides have tangible pressure pain point at neck.

Nervous headache, the headache that mainly comprises headache that the neurasthenia causes and cause because of hysteria.Its control is very complicacy and an elaboration.The traditional Chinese medical science is thought, the generation of nervous headache and affection of exogenous wind-cold, damp and hot or internal injury, and like temperament and interest imbalance, factor such as disturb on healthy energy loss, qi stagnation blood stasis, expectorant are turbid is relevant.The Chinese medicine of the treatment nervous headache of at present having announced is less; The medicine majority of treatment nervous headache is a Western medicine at present; Though these medicines have certain curative effect to the treatment nervous headache, the side effect of Western medicine is big, and other organ of health is had certain side effect.

Summary of the invention

The purpose of this invention is to provide a kind of medicine of treating nervous headache, it can treating both the principal and secondary aspects of a disease, has no side effect.

Medicine of the present invention is that the Chinese medicine of following column weight amount umber is the medicament that crude drug makes:

Rhizoma Ligustici 10-15 Fructus Viticises 10-15

The Radix Angelicae Dahuricae 8-12 Rhizoma Chuanxiongs 10-15

Radix Paeoniae Rubra 10-15 Radix Paeoniae Albas 10-20

Radix Angelicae Sinensis 10-30 Radix Salviae Miltiorrhizaes 10-30

Poria cum Radix Pini's 10-30 Ramulus Uncariae Cum Uncis 10-20

Radix Scrophulariae 10-20 Rhizoma Gastrodiaes 8-15

Pheretima 5-10 Rhizoma Corydalis 10-15

Concha Margaritifera 10-30 Radix Glycyrrhizaes 3-5.

The preferred parts by weight of each crude drug of medicine of the present invention are:

Rhizoma Ligustici 10-12 Fructus Viticises 10-12

The Radix Angelicae Dahuricae 8-10 Rhizoma Chuanxiongs 10-12

Radix Paeoniae Rubra 10-12 Radix Paeoniae Albas 10-18

Radix Angelicae Sinensis 10-15 Radix Salviae Miltiorrhizaes 10-15

Poria cum Radix Pini's 10-15 Ramulus Uncariae Cum Uncis 10-15

Radix Scrophulariae 10-20 Rhizoma Gastrodiaes 8-12

Pheretima 5-10 Rhizoma Corydalis 10-15

Concha Margaritifera 10-30 Radix Glycyrrhizaes 3-5.

Can said medicine be processed any dosage form on the pharmaceutics, like tablet, pill, capsule etc., the preferred capsule of the present invention.

With the concrete method for preparing of medicine of the present invention be:

A) get Pheretima and add yellow wine and soak and stir, taking-up is dried subsequent use when putting into pot and frying to little yellow with little fire;

B) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;

C) said process of preparing Chinese medicine medicine and all the other ten four Chinese medicine things are added water logging and do not have decocting for Chinese herbal medicine, decoct 3 times, each 1.5h; Filter the back and mix filtrating three times; Be condensed into the thick paste of 50 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, be mixed and made into capsule with starch.

In the prescription of the present invention, Rhizoma Ligustici is dispeled the wind, cold expelling, dehumidifying, pain relieving; The Fructus Viticis dispelling wind and heat pathogens, the clear sharp head; Radix Angelicae Dahuricae expelling wind and cold, understand things pain-stopping, detumescence and apocenosis; The Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; Radix Paeoniae Rubra clots absorbing, pain relieving, removing heat from blood, detumescence; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant; Radix Angelicae Sinensis can be enriched blood, and invigorates blood circulation regulating menstruation, pain relieving, intestine moistening; The Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Poria cum Radix Pini's mind calming, calm the nerves, diuretic; Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; The Radix Scrophulariae clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing; Rhizoma Gastrodiae embellishes but not dry, and the master goes into Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, and the disease of all liver-wind stirring up internallys, the vertigo is no matter deficiency and excess is key medicine; Pheretima salty in the mouth cold in nature, heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging; Rhizoma Corydalis is warm in nature, and acrid in the mouth is bitter, goes into the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is world-famous for the effect of pain relieving especially; The Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, calm the nerves, calming the frightened makes eye bright; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicine combinations, expelling wind and cold, understand things pain-stopping, clearing away heat and cooling blood, invigorating the spleen and replenishing QI, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.

Use the capsule of medicine of the present invention that the treatment nervous headache has been carried out safety and observation of curative effect clinically.

1, patient's data

All get rid of during diagnosis owing to upper respiratory tract infection, sinusitis, hypertension, the caused headache of intracranial infection, the patient is 121 examples altogether, are divided into 2 groups at random; Treatment is organized among the 68 routine patients, male 25 examples, women 43 examples; 15-60 years old ages; 36.4 years old mean age, the course of disease 3 months-10 years, average 5-6 years; Among the matched group 53 routine patients, male 28 examples, women 25 examples, 14-58 years old ages, 35.2 years old mean age, the course of disease 2 months-8 years, average 4-5 years.

2, diagnostic criteria

" new Chinese medicine clinical research guideline " curative effect determinate standard according to Ministry of Public Health formulation in 1993 is drafted:

Have the medical history of outbreak repeatedly, continue tens of minutes, several hours or a couple of days at every turn;

At a side or bilateral or full head, its character belongs to jumping pain, distending pain, acupuncture appearance pain etc. during outbreak, and si dol urg the companion feel sick, vomiting;

Aethomma can be arranged, premonitory symptoms such as blackout before the outbreak;

In conjunction with electroencephalogram, rheoencephalogram and laboratory detection etc., through rheoencephalogram and through head Doppler inspection, all prompting " enhancing of cerebrovascular tensity " reaches " cerebral arterial insufficiency ".

3, Therapeutic Method

The matched group patient is the sharp crop capsule in oral hydrochloride fluorine osmanthus half an hour after meal all, each 15mg, every day 2 times, each 10 mg of oryzanol, every day 3 times; The tablet of oral medicine of the present invention is organized in treatment, and 3 times on the one, each 3; Be 1 month the course of treatment.

4, efficacy assessment standard

According to " the new Chinese medicine clinical research guideline " of Ministry of Public Health formulation in 1993, cure: headache and simultaneous phenomenon disappear, recurrence more than half a year; Effectively: headache and simultaneous phenomenon disappear or alleviate; Year there is recurrence drug withdrawal half a year-1, but attack times reduces, and pain degree alleviates; Invalid: headache and simultaneous phenomenon all do not have improvement.

5, therapeutic effect

Treatment is organized among the 68 routine patients, cures 45 examples, effective 21 examples, invalid 2 examples, cure rate 66%, total effective rate 97%, inefficiency 3%.Among the matched group 53 routine patients, cure 22 examples, effective 23 examples, invalid 8 examples, cure rate 42%, total effective rate 85%, inefficiency 15%.Treatment group cure rate is apparently higher than matched group, and the matched group patient has 7 routine patient bodies malaise symptoms to occur in taking the process of medicine.

The specific embodiment

Embodiment 1

Get Rhizoma Ligustici 5kg, Fructus Viticis 5.5 kg, the Radix Angelicae Dahuricae 4 kg, Rhizoma Chuanxiong 7 kg, Radix Paeoniae Rubra 6 kg, the Radix Paeoniae Alba 10 kg; Radix Angelicae Sinensis 6 kg, Radix Salviae Miltiorrhizae 10 kg, Poria cum Radix Pini 15 kg, Ramulus Uncariae Cum Uncis 7 kg, Radix Scrophulariae 5 kg; Rhizoma Gastrodiae 4 kg, Pheretima 3 kg, Rhizoma Corydalis 6 kg, Concha Margaritifera 10 kg, Radix Glycyrrhizae 2.5 kg;

A) Pheretima is added yellow wine and soak and stir, taking-up is dried subsequent use when putting into pot and frying to little yellow with little fire;

B) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;

C) said process of preparing Chinese medicine medicine and all the other ten four Chinese medicine things are added water logging and do not have decocting for Chinese herbal medicine, decoct 3 times, each 1.5h; Filter the back and mix filtrating three times; Be condensed into the thick paste of 50 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, add 0.5kg starch and process capsule.

Embodiment 2

Get Rhizoma Ligustici 3kg, Fructus Viticis 3.5kg, Radix Angelicae Dahuricae 3kg, Rhizoma Chuanxiong 3.3 kg, Radix Paeoniae Rubra 3kg, the Radix Paeoniae Alba 4.5 kg, Radix Angelicae Sinensis 4 kg, Radix Salviae Miltiorrhizae 4kg, Poria cum Radix Pini 3kg, Ramulus Uncariae Cum Uncis 4.5kg, Radix Scrophulariae 5kg, Rhizoma Gastrodiae 3kg, Pheretima 1.5kg, Rhizoma Corydalis 4kg, Concha Margaritifera 9 kg, Radix Glycyrrhizae 1.2 kg;

A) Pheretima is added yellow wine and soak and stir, taking-up is dried subsequent use when putting into pot and frying to little yellow with little fire;

B) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;

C) said process of preparing Chinese medicine medicine and all the other ten four Chinese medicine things are added water logging and do not have decocting for Chinese herbal medicine, decoct 3 times, each 1.5h; Filter the back and mix filtrating three times; Be condensed into the thick paste of 50 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, add 0.2kg starch and process capsule.

Claims (3)

1. medicine of treating nervous headache is characterized in that the crude drug by following parts by weight is the medicament that feedstock production obtains:

Rhizoma Ligustici 10-15 Fructus Viticises 10-15

The Radix Angelicae Dahuricae 8-12 Rhizoma Chuanxiongs 10-15

Radix Paeoniae Rubra 10-15 Radix Paeoniae Albas 10-20

Radix Angelicae Sinensis 10-30 Radix Salviae Miltiorrhizaes 10-30

Poria cum Radix Pini's 10-30 Ramulus Uncariae Cum Uncis 10-20

Radix Scrophulariae 10-20 Rhizoma Gastrodiaes 8-15

Pheretima 5-10 Rhizoma Corydalis 10-15

Concha Margaritifera 10-30 Radix Glycyrrhizaes 3-5.

2. the medicine of treatment nervous headache according to claim 1 is characterized in that being is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Rhizoma Ligustici 10-12 Fructus Viticises 10-12

The Radix Angelicae Dahuricae 8-10 Rhizoma Chuanxiongs 10-12

Radix Paeoniae Rubra 10-12 Radix Paeoniae Albas 10-18

Radix Angelicae Sinensis 10-15 Radix Salviae Miltiorrhizaes 10-15

Poria cum Radix Pini's 10-15 Ramulus Uncariae Cum Uncis 10-15

Radix Scrophulariae 10-20 Rhizoma Gastrodiaes 8-12

Pheretima 5-10 Rhizoma Corydalis 10-15

Concha Margaritifera 10-30 Radix Glycyrrhizaes 3-5.

3. the method for preparing of claim 1 or 2 said treatment nervous headache medicines may further comprise the steps:

A) get Pheretima and add yellow wine and soak and stir, taking-up is dried subsequent use when putting into pot and frying to little yellow with little fire;

B) mixing when putting into pot and frying to little yellow with little fire Rhizoma Corydalis thoroughly taking-up with vinegar dries subsequent use;

C) said process of preparing Chinese medicine medicine and all the other ten four Chinese medicine things are added water logging and do not have decocting for Chinese herbal medicine, decoct 3 times, each 1.5h; Filter the back and mix filtrating three times; Be condensed into the thick paste of 50 ℃ of relative densities 1.20～1.24, obtain medicine activity component after the drying and crushing, be mixed and made into capsule with starch.