CN101077407A - Medicine for treating depression caused by simple emotion factor - Google Patents
Medicine for treating depression caused by simple emotion factor Download PDFInfo
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Abstract
The present invention relates to one kind of medicine for treating depression caused by single emotional mood factor, and its extraction process and preparation process.
Description
Technical field
What the present invention relates to is a kind of medicine for the treatment of the depression that simple emotion factor causes, also relates to extracting method of this medicine and preparation method thereof.
Technical background
Depression is a kind of affective psychosis, is feature with emotion such as sad, desperate and dejected.Patient Chang You feels oneself inferior, feels guilty and guilty certainly sensation, and suicidal tendency can be arranged.Depression has a strong impact on people's quality of life, and work efficiency is descended, and the various invisible loss that cause are costly.
Abroad, statistics shows that the sickness rate of U.S.'s depression is only second to heart disease, and between 6%～8%, the sickness rate in crowd more than 60 years old will be up to 20%～50% at the sickness rate of the lifelong depression of west industrially developed country.It is predicted that these national depression sickness rate can be brought up to about 8%～10% 2005.The U.S. estimates at 1,700 ten thousand people and suffers from depression, and Canada estimates have 800,000 people to suffer from depression approximately.
In China, along with the quickening of Chinese society rhythm of life, the enhancing of various pressure, the prevalence of mental sickness is ascendant trend year by year, and patients with depression has accounted for 20%～30% of this outpatient service ward total number of persons at present.Estimate according to another the expert, Chinese patients with depression accept rational therapy ratio will from present 25% rise to 2010 40%.According to " calendar year 2001 World Health Report " that World Health Organization (WHO) not long ago delivered, depression has become the fourth-largest illness in the world at present, may become to the year two thousand twenty depression to be only second to cardiopathic second largest disease.Depression is just becoming serious global problems.
By theory of Chinese medical science, from traditional Chinese medical science angle, depression belongs to " melancholia " category, the cause of disease be disgruntled, ponder over, damaged by excess of seven emotions such as grief, sorrow, cause feelings will not freely, depression and stagnation of QI.Clinical manifestation is the worried or not peaceful multiclass syndrome of emotion.The Chinese traditional treatment melancholia is taked method of treatment such as dispersing the stagnated live-QI to relieve the stagnation of QI, QI and blood regulating more.
Chinese patent CN200410070126.2, name is called " preparation technology of YUEJU JIAONANG and method of quality control ", this invention discloses the test of YUEJU JIAONANG antidepressant in specific embodiment, as: the antagonism reserpine causes motion and can not test by depression model, to the acquired desperate depression model test of mice, behavioristics's test of chronic stress depression model, the test of trembling of L-5-oxitriptan induced mice, strengthen the test of levodopa behavior effect, YUEJU extractum is to the influence of spontaneous activity in mice, the threshold dose pentobarbital sodium is tested together with hypnosis, liver depression model test etc.The sphere of action of treatment depression is wide, the Therapeutic Principle that can not bring into play the Chinese medicine determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.
The 13rd the 3rd phase of volume of " folks of china therapy " March in 2005, disclose Yueju Wan and added flavor and close fluoxetine treatment post-stroke depression 60 examples; It is main formula treatment involutional depression 32 examples that " Chinese convalescent medicine " 1997 the 6th the 1st phases of volume disclose Yueju Wan, the 19th the 3rd phase of volume of " traditional Chinese medical science forum " May in 2004 discloses the discussion that Yueju Wan is used for the treatment of depression, though more than each document in various degree the depressed card of Yueju Wan plus-minus treatment disclosed, but each prescription all is to add and subtract at the pathogenetic difference of some patient, few person adds two or three flavor medicine, many person's six, seven flavors, the treating depression that is used at specific crowd can not be enlarged, suitability for industrialized production can not be carried out simultaneously.
Summary of the invention
For overcoming the shortcoming of the depressed medicine of above existing treatment, the invention provides the medicine of the depression that a kind of treatment causes by simple emotion factor.
The medicine of the depression that the simple feelings will of treatment provided by the invention factor causes, make by following parts of medicines by weight:
30～90 parts of 30～90 parts of Rhizoma Chuanxiongs of 30～90 portions of Rhizoma Cyperis of Rhizoma Atractylodis
30～90 parts of 30～90 portions of Radix Curcumaes of 30～90 portions of Fructus Gardeniaes of Massa Medicata Fermentata
The more excellent parts by weight scope of pharmaceutical formulation of the present invention is:
50～70 parts of 50～70 parts of Rhizoma Chuanxiongs of 50～70 portions of Rhizoma Cyperis of Rhizoma Atractylodis
50～70 parts of 50～70 portions of Radix Curcumaes of 50～70 portions of Fructus Gardeniaes of Massa Medicata Fermentata
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the oral formulations of any routine, but in order to make the Chinese crude drug in this medicine bring into play better drug effect, is necessary medical material is carried out the extraction of active component.
Another object of the present invention provides the extracting method of the medicine of the depression that causes of the simple feelings will factor of treatment:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, collect volatile oil, and standby, volatile oil also can be with standby behind the beta-cyclodextrin inclusion compound, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, in b, the side, and merge extractive liquid, filters, and the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, and filters, reclaim ethanol and do not distinguish the flavor of, and be condensed into clear paste, be spray dried to dry extract to there being alcohol;
C, the volatile oil of step a preparation or the volatile oil of beta-cyclodextrin inclusion compound and the dry extract of step b preparation are merged, promptly get extract.
Another object of the present invention provides the preparation method of the medicine of the depression that causes of the simple feelings will factor of treatment, concrete is exactly to add the required various conventional adjuvant of preparation different dosage form in the extract among the step c, as disintegrating agent, lubricant, binding agent etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, capsule, soft capsule, pill, powder, oral liquid etc.
Solution of the present invention is based on modern medicine and motherland's medical science to pathogenetic understanding of depression and Therapeutic Principle, with reference to modern pharmacology, study of pharmacy achievement, from motherland's medicine treasure-house, by the theory of Chinese medical science prescription, filter out promoting QI circulation for relieving depression, drying damp and strengthening spleen, the promoting the circulation of blood of invigorating blood circulation, the natural plant of clearing heat and relieving fidgetness is with the treatment depression.
Simultaneously, pharmacological testing confirms that the medicine energy dose dependent ground improvement of the depression that the simple feelings will of treatment of the present invention factor causes and inhibition are because of the depression of forced swimming test and outstanding tail test-induced, and effect is remarkable than Yueju Wan.
The specific embodiment
The present invention is illustrated by the following example, but should not be construed as limiting the invention.
The capsule of the medicine of the depression that embodiment one, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 60g Rhizoma Cyperi 60g Rhizoma Chuanxiong 60g
Massa Medicata Fermentata 180g Fructus Gardeniae 180g Radix Curcumae 180g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, collect volatile oil, and volatile oil is standby after with beta-cyclodextrin inclusion compound, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, and merge extractive liquid, filters, the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, filter, reclaim ethanol and do not distinguish the flavor of, and be condensed into clear paste, be spray dried to dry extract to there being alcohol;
C, the volatile oil of the beta-cyclodextrin inclusion compound of step a preparation and the dry extract of step b preparation are merged, granulate, add magnesium stearate 2g, encapsulated, make 1000 capsules.
The capsule of the medicine of the depression that embodiment two, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 180g Rhizoma Cyperi 60g Rhizoma Chuanxiong 180g
Massa Medicata Fermentata 60g Fructus Gardeniae 180g Radix Curcumae 60g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, and it is standby to collect volatile oil, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, and merge extractive liquid, filters, the aqueous solution that filtrate and step a collect merges, and concentrates, and adds ethanol, cold preservation is spent the night, filter, reclaim ethanol to nothing alcohol flavor, and be condensed into clear paste, technology vacuum drying routinely, dry product is ground into fine powder;
C, with the volatile oil of step a preparation with merge with the dry extract of step b preparation again after micropowder silica gel mixes, mixing, content, granulation, adding Pulvis Talci 1g, encapsulated, make 1000.
The tablet of the medicine of the depression that embodiment three, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 140g Rhizoma Cyperi 140g Rhizoma Chuanxiong 100g
Massa Medicata Fermentata 140g Fructus Gardeniae 100g Radix Curcumae 100g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, collect volatile oil, and volatile oil is standby after with beta-cyclodextrin inclusion compound, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, and merge extractive liquid, filters, the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, filter, reclaim ethanol and do not distinguish the flavor of, and be condensed into clear paste, be spray dried to dry extract to there being alcohol;
C, the volatile oil of the beta-cyclodextrin inclusion compound of step a preparation and the dry extract of step b preparation are merged, the preparation method of tablet is granulated routinely, adds magnesium stearate 10g, tabletting, and coating, packing gets product.
The granule of the medicine of the depression that embodiment four, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 80g Rhizoma Cyperi 80g Rhizoma Chuanxiong 160g
Massa Medicata Fermentata 160g Fructus Gardeniae 160g Radix Curcumae 80g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, collect volatile oil, and standby with beta-cyclodextrin inclusion compound, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, and merge extractive liquid, filters, the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, filter, reclaim ethanol and do not distinguish the flavor of, and be condensed into clear paste, be spray dried to dry extract to there being alcohol;
C, the volatile oil of the beta-cyclodextrin inclusion compound of step a preparation and the dry extract of step b preparation are merged, mixing adds conventional adjuvant, granulates, and packing gets product.
The tablet of the medicine of the depression that embodiment five, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 140g Rhizoma Cyperi 100g Rhizoma Chuanxiong 100g
Massa Medicata Fermentata 140g Fructus Gardeniae 140g Radix Curcumae 100g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, and it is standby to collect volatile oil, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, and merge extractive liquid, filters, the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, filter, reclaim ethanol and do not distinguish the flavor of, and be condensed into clear paste, be spray dried to dry extract to there being alcohol;
C, with the volatile oil of step a preparation with merge with the dry extract of step b preparation again after micropowder silica gel mixes, mixing is granulated, the adding magnesium stearate is an amount of, tabletting, coating is packed, and gets product.
The soft capsule of the medicine of the depression that embodiment six, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 120g Rhizoma Cyperi 120g Rhizoma Chuanxiong 120g
Massa Medicata Fermentata 120g Fructus Gardeniae 120g Radix Curcumae 120g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, and it is standby to collect volatile oil, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, and merge extractive liquid, filters, the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, filter, reclaim ethanol and do not distinguish the flavor of, and be condensed into clear paste, be spray dried to dry extract to there being alcohol;
C, the volatile oil of step a preparation and the dry extract of step b preparation are merged,, change glue, pelleting, wash ball, make 1000 of soft capsules with soybean oil 242g, isosorbide mononitrate 0.1g mix homogeneously.
The soft capsule of the medicine of the depression that embodiment seven, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 100g Rhizoma Cyperi 140g Rhizoma Chuanxiong 100g
Massa Medicata Fermentata 140g Fructus Gardeniae 100g Radix Curcumae 140g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors are used steam distillation in a, (1) side, extract volatile oil, and relative density 1.2-1.3 when remaining decocting liquid is concentrated into 50 ℃ gets extractum 1.
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavor waters decoct three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, collecting decoction, relative density 1.2-1.3 when being concentrated into 50 ℃ gets extractum 2.
C, extractum 1, extractum 2 merges, technology vacuum drying routinely, and dry product is ground into fine powder, adds volatile oil, with soybean oil 108g, lecithin 3.6g and Cera Flava 3.6g mix homogeneously,, change glue, pelleting, wash ball by the preparation of soft capsule method, make 1000 of soft capsules, packing gets product.
The granule of the medicine of the depression that embodiment eight, the simple feelings will factor of treatment cause
1, prescription: Rhizoma Atractylodis 120g Rhizoma Cyperi 120g Rhizoma Chuanxiong 120g
Massa Medicata Fermentata 120g Fructus Gardeniae 120g Radix Curcumae 120g
2, preparation method:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors are used steam distillation in a, the side, extract volatile oil, and with gained volatile oil cyclodextrin inclusion compound, relative density 1.2-1.3 when decocting liquid is concentrated into 50 ℃ gets extractum 1.
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavor waters decoct three times in b, the side, boil 2 hours with 10 times of decoctings for the first time, and 8 times of water gagings decocted 1.5 hours for the second time, 8 times of water gagings decocted 1.5 hours for the third time, collecting decoction, relative density 1.2-1.3 when being concentrated into 50 ℃ gets extractum 2.
C, extractum 1, extractum 2 is merged, technology vacuum drying routinely, dry product is ground into fine powder, adds the volatile oil of cyclodextrin inclusion compound, evenly, dry powder, the preparation method of granule adds conventional axle material routinely, granulates, packing gets product.
With the soft capsule preparation among the embodiment six is essential drugs, and depression model by forced swimming test and outstanding tail test-induced and Yueju Wan carry out the comparison of pharmacodynamics test with regard to the depression that simple feelings will factor causes, method is as follows:
Embodiment nine: outstanding tail is tested the influence of the depression model that causes with mandatory swimming test
Experimental animal: Male Kunming strain mice, body weight 19.04 ± 0.8g, totally 60.
The test grouping: be divided into 6 groups at random by body weight, 10 every group, the blank group gives distilled water, and positive control drug is respectively Yueju Wan, amitriptyline sheet (dosage 70mg/kg), and the Yueju Wan dosage is equivalent to per kilogram of body weight 600mg crude drug.Medicine low dose group (abbreviation low dose group), dosage that medicine of the present invention is divided into dosage group in the medicine of the medicine high dose group (abbreviation high dose group) of the depression that causes of the simple feelings will factor of treatment, depression that the simple feelings will factor of treatment causes and treats the depression that simple feelings will factor causes are equivalent to per kilogram of body weight 900mg crude drug/kg, 600mg crude drug/kg, 300mg crude drug/kg, gastric infusion respectively.
Test method: test the 1st day every Mus and hang tail test and mandatory swimming test in advance, to induce depression model.In inductive the 2nd day beginning gastric infusion, after the 1st administration, measured the mice autonomic activities in 1 hour, repeat outstanding tail and swimming test then, continuous 7 days.
Result of the test:
1, mice autonomic activities: observe cross-line number in 5 minutes (rice a word line be as the criterion), uprightly probe into number (lift be as the criterion with mice two forelimbs) and the two ratio.The results are shown in Table 1.
Compare with the blank group, amitriptyline, Yueju Wan and high, medium and low dosage group difference of the present invention do not have significance.
Table 1: soft capsule of the present invention to the influence of mice autonomic activities (X ± s, n=10)
| Group | Dosage (mg) | Probe into number of times (inferior/5 minute) | Cross-line number of times (inferior/5 minute) | Probe into/cross-line |
| Dosage group low dose group in the blank group amitriptyline Yueju Wan group high dose group | 70 600 900 600 300 | 23.13±10.52 20.16±15.01 23.16±16.56 18.67±17.34 16.98±25.31 20.13±15.89 | 50.60±13.73 54.12±14.16 53.12±26.33 39.2±19.86 42.01±20.11 50.12±23.06 | 0.38±0.16 0.36±0.13 0.44±0.25 0.36±0.57 0.40±0.22 0.43±0.48 |
2, mouse tail suspension test: the position of mice tail end 2cm is fixed with female clip, hung by the feet in 12 * 27 * 27 (cm) case, its head is about 5cm from the bottom surface, hangs 6min, writes down thereafter and accumulates the dead time in the 4min.The results are shown in Table 2.
Compare with the blank group, the amitriptyline group all obviously shortened the outstanding tail dead time at the 3rd, five, seven day, the Yueju Wan group can significantly shorten the outstanding tail dead time in the time of the 7th day, height of the present invention, middle dosage group can obviously shorten the outstanding tail dead time, and low dose group can obviously shorten the outstanding tail time when trisome.
Table 2: soft capsule of the present invention to the influence of mouse tail suspension dead time (X ± s, n=10)
| Group | Dosage (mg) | The accumulation dead time (second) | |||
| Before the administration | The 3rd day | The 5th day | The 7th day | ||
| Dosage group low dose group in the blank group amitriptyline Yueju Wan group high dose group | 70 600 900 600 300 | 96.13 ± 41.52 108.16 ± 35.01 83.16 ± 46.56 108.67 ± 47.34 106.98 ± 35.51 100.13 ± 45. | 78.63±34.07 46.19±29.81 ※※ 100.16±46.56 91.57±37.84 ※※ 80.18±43.18 ※※ 92.13±45.89 ※※ | 125.60±13.73 34.12±23.06 ※※ 103.12±34.33 89.32±19.86 ※※ 82.01±20.11 ※※ 100.12±23.06 | 149.38±37.16 30.36±20.13 ※※ 98.44±50.25 92.36±13.57 ※※ 90.40±50.27 ※※ 130.43±45.27 |
Annotate: compare with the blank group,
※ ※P＜0.01.
3, the mandatory swimming test of mice: mice is put into high 20cm, in the column type glass jar of diameter 12cm, depth of water 12cm, 25 ℃ of water temperatures are observed 6min, write down thereafter and accumulate the dead time in the 4min.Dead time is meant that mice stops to struggle in water, or is floating state, and the persistent period of tiny limb motion to keep head to keep afloat only arranged.The results are shown in Table 3.
With the blank group relatively, shortening mice dead time that the dosage group all can be in various degree among amitriptyline and the present invention, and difference has significance, high dose group in the time of the 5th, seven day, effect obviously, and the Yueju Wan group only just had obvious effect in the time of the 7th day.
Table 3: the present invention to the influence of the mandatory swimming test of mice (X ± s, n=10)
| Group | Dosage (mg) | The accumulation dead time (second) | |||
| Before the administration | The 3rd day | The 5th day | The 7th day | ||
| Dosage group low dose group in the blank group amitriptyline Yueju Wan group high dose group | 70 600 900 600 300 | 76.13±21.02 78.16±21.45 83.16±46.45 88.27±37.39 86.98±35.51 100.13±45.89 | 88.04±44.97 46.64±26.81 ※※ 82.16±14.56 71.57±37.84 70.18±43.18 ※※ 82.13±45.89 | 101.60±41.53 43.12±38.04 ※※ 73.12±46.33 69.32±19.86 ※※ 52.01±20.11 ※※ 100.12±23.06 | 124.43±30.76 40.34±32.83 ※※ 71.44±31.25 ※※ 62.36±0.57 ※※ 60.40±0.27 ※※ 106.43±0.27 |
Annotate: compare with the blank group,
※P＜0.05,
※ ※P＜0.01.
To sum up, ground improvement of the medicine of the depression that the simple feelings will of treatment of the present invention factor causes energy dose dependent and inhibition are because of the depression of forced swimming test and outstanding tail test-induced, and effect is remarkable than Yueju Wan.
Claims (4)
1, a kind of medicine for the treatment of the depression that simple emotion factor causes, make by following parts of medicines by weight:
30～90 parts of 30～90 parts of Rhizoma Chuanxiongs of 30～90 portions of Rhizoma Cyperis of Rhizoma Atractylodis
30～90 parts of 30～90 portions of Radix Curcumaes of 30～90 portions of Fructus Gardeniaes of Massa Medicata Fermentata
2, the medicine of the depression that causes of treatment simple emotion factor according to claim 1 is characterized in that the parts by weight scope is:
50～70 parts of 50～70 parts of Rhizoma Chuanxiongs of 50～70 portions of Rhizoma Cyperis of Rhizoma Atractylodis
50～70 parts of 50～70 portions of Radix Curcumaes of 50～70 portions of Fructus Gardeniaes of Massa Medicata Fermentata
3, the medicine of the depression that causes of treatment simple emotion factor according to claim 1 and 2 is characterized in that its extraction process is as follows:
Rhizoma Atractylodis, Rhizoma Cyperi, Radix Curcumae three flavors extract with steam distillation in a, the side, collect volatile oil, and standby, volatile oil also can be with standby behind the beta-cyclodextrin inclusion compound, and the aqueous solution after distillation device is in addition collected;
Rhizoma Chuanxiong, Massa Medicata Fermentata, Fructus Gardeniae three flavors add the water reflux, extract, in b, the side, and merge extractive liquid, filters, and the aqueous solution that filtrate and step a collect merges, concentrate, add ethanol, cold preservation is spent the night, and filters, reclaim ethanol and do not distinguish the flavor of to there being alcohol, and be condensed into clear paste, spray drying or conventional drying under reduced pressure become dry extract;
C, the volatile oil of step a preparation or the volatile oil of beta-cyclodextrin inclusion compound and the dry extract of step b preparation are merged, extract.
4, the medicine of the depression that causes of treatment simple emotion factor according to claim 1 and 2, it is characterized in that the extract among the step c is added the required various conventional adjuvant of preparation different dosage form, be prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine.
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| CN200610012739XA CN101077407B (en) | 2006-05-22 | 2006-05-22 | Medicine for treating depression caused by simple emotion factor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940857A (en) * | 2012-12-17 | 2013-02-27 | 成都中医药大学 | Medicine composition for treating depression and preparation method thereof |
| CN104606536A (en) * | 2015-01-07 | 2015-05-13 | 南京中医药大学 | Traditional Chinese medicine composition with anti-depression function and application of traditional Chinese medicine composition |
-
2006
- 2006-05-22 CN CN200610012739XA patent/CN101077407B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940857A (en) * | 2012-12-17 | 2013-02-27 | 成都中医药大学 | Medicine composition for treating depression and preparation method thereof |
| CN104606536A (en) * | 2015-01-07 | 2015-05-13 | 南京中医药大学 | Traditional Chinese medicine composition with anti-depression function and application of traditional Chinese medicine composition |
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| Publication number | Publication date |
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| CN101077407B (en) | 2011-04-27 |
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