CN102058848A - Application of Tibetan medicine composition to preparation of medicine for treating central neuropathic pains - Google Patents
Application of Tibetan medicine composition to preparation of medicine for treating central neuropathic pains Download PDFInfo
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Abstract
The invention discloses application of a Tibetan medicine composition to the preparation of a medicine for treating central neuropathic pains. The Tibetan medicine composition consists of the following raw material medicines in part by weight: 5 to 15 parts of lamiophlomis, 2 to 10 parts of whin, 15 to 60 parts of turmeric, 7 to 20 parts of pricklyash peel, 5 to 15 parts of buffalo horn, 15 to 40 parts of myricaria, 0.1 to 2.5 parts of safflower, 0.1 to 5 parts of borneol and 0.1 to 5 parts of camphor. Further researches on the pharmacology of the conventional Tibetan medicine composition prove that the Tibetan medicine composition has good effect of relieving the central neuropathic pains; in addition, the Tibetan medicine composition is prepared from purely natural wild medicinal materials produced in Tibet plateau, is not added with any chemically synthesized stabilizer, does not have any toxic or side effect on human bodies, is safe and effective, and is suitable for various people and suitable for treating various central neuropathic pains.
Description
Technical field
The present invention relates to field of medicaments, the application of particularly a kind of Tibetan medicine compositions in preparation treatment nervus centralis pain medication.
Background technology
Nervus centralis pain is a kind of common clinically disease, be meant the caused pain of the disease that is primary in the central nervous system, the main position of involving is spinal cord-thalamus path or funiculus posterior medullae spinalis Reil's ribbon, and its outbreak often postpones after risk factor, is the most thorny a kind of pain syndrome.With pain credit class, it can be belonged to neuropathic pain, neuropathic pain or systemic pain, in rehabilitation medicine, generally it is belonged to chronic pain, be called " nervus centralis pain syndrome " again.Be divided into pain after Spinal Cord Injury and post-stroke pain anatomically, the sings and symptoms of both performances may be fully different, and modal reason is vascular conditions, injures demyelination outward.
The patient of nervus centralis pain often has the clinical manifestation of tangible constitutional central nervous system pathological change, as depth sensory disturbance, dyskinesia, reflectance anomaly etc., and patient's pain symptom is comparatively outstanding, certain stage in the course of disease often becomes to be chief complaint, and become the major issue that restricts the patient body function, seriously reduce patient's life quality.No matter nervus centralis pain results from the infringement of brain level, still the infringement of spinal levels all exists common clinical manifestation and characteristics, and promptly (1) pain often postpones to occur after primary lesion, begin to occur as pain symptom after 1 week of Thalamic Apoplexy or several weeks, have in addition " hiding " several months; (2) zone of pain normal with the area part of somesthesia obstacle or disappearance or all consistent, i.e. discovery is felt and is gone down or anesthetic limbs and be the limbs of patient main suit's pain during clinical examination; (3) the non-afferent pain due to the infringement of the character of pain and peripheral nervous is similar, and it is that persistence dull pain, fiber crops are stung the sample pain, burn sample pain or the sense of band lock ring that the patient describes normal; Nervus centralis pain character is comparatively fixing, and transience lancinate sample or the outbreak of electric shock sample acute pain can be arranged sometimes, to severe, even is difficult to stand in mostly being on the degree, also can change on distributing; (4) follow the emotion color of pain heavier, consequently often being mistaken as is pure psychological problems; Along with the fluctuation of emotion, pain degree obviously rises and falls.
The pathogenesis of nervus centralis pain is very complicated, does not illustrate fully as yet at present.Any position on the generation of nervus centralis pain almost relates in the central nervous system along spinal cord, brain stem, thalamus to the pathway of cortex, as long as taking place, pathological lesion all might produce nervus centralis pain, but its cause effect relation is very not clear and definite again, even the identical pathological lesion of same structure has only the part patient nervus centralis pain to occur also.Through research for many years, medical domain generally believes that the generation of nervus centralis pain causes by central nervous system's irritability is too high now.In addition, also observe nervus centralis pain clinically and exist tangible individual variation, psychology and social factor play an important role.
Part nervus centralis pain has reversibility, and the nervus centralis pain due to some post-stroke or the myelitis is without special treatment or through generally all can correspondingly being eased behind the symptomatic treatment.But its general course of disease is longer, reaches 3 months to more than half a year.In fact, most of nervus centralis treatment of pain is all very difficult, and pay close attention to alleviates or alleviating pain and be difficult to reach eliminate pain more in treatment.Nervus centralis treatment of pain method mainly contains psychotherapy, naturopathy, acupuncture treatment, Drug therapy and operative treatment, and is wherein general with Drug therapy.
From the treatment theory of Tibetan medicine, Tibetan medicine's theory on three categories of etiologic factors thinks, grand, red crust, three factors of Baconic are the bases that constitute body substances, also are to carry out vital movement indispensable energy of institute and basis.Wherein, grand is the assembly with 6 kinds of attributes such as thick, light, cold, thin, hard, moving, be the synthesis of function relations such as breathing, motion, drainage, circulation, sensation, immunity of organism, because the difference at its position of living in, can be divided into first, tie up to order and swell, it is positioned at head, runs on neck, breast, and the drink pharynx of main department, breathing, saliva are distinguished the flavor of, spat, thinking, sense organ etc.; The second, up grand, be positioned at chest, run on nose, tongue, pharyngeal, main department language, mind, color and luster, will, idea etc.; Three, spread all over grandly, be positioned at heart, run on whole body, main department blood circulation, muscle power, extremity operation etc.; Four, flat fire is grand, is positioned at heart, runs on whole body, main department blood circulation, muscle power, extremity operation etc.; Five, let out grandly down, be positioned at anus, run on large intestine, bladder, genitals, femoribus internus, main department essence and blood, two just, childbirth etc.
Red crust be fine and smooth, sharp, hot, light, smelly, let out, the assembly of 7 kinds of attributes such as tide, be the synthesis of function relations such as body temperature, digestion, because the difference at its position of living in can be divided into first, digest red crust, between gastrointestinal, the digestion of main department, decomposition, body temperature etc.; The second, the red crust of variable color is positioned at liver, the precise and tiny color of main department, for pigment this; Three, the red crust of function is positioned at heart, main department desire, wisdom etc.; Four, the red crust of photopic vision is positioned at eye, main department vision; Five, the red crust of light colour is positioned at skin, and main department moistens fur, gives birth to the body pool.
Baconic be lubricate, cold and cool, heavy, pure, soft, glutinous, the assembly of sticking with paste 7 kinds of attributes, be the synthesis of relation such as the function of lubricating, keep fit of connection, the articular cavity of skeleton.Because the difference at its position of living in can be divided into first, can be positioned at chest according to Baconic, is other 4 kinds of Baconics' basis; The second, mix and stir Baconic, be positioned at stomach, the mixing to stir of main department food grinds, and increases the wriggling and the secretion of stomach; Three, sense of taste Baconic is positioned at tongue, the main department sense of taste; Four, foot feel Baconic is positioned at brain, the excitement of main department, consciousness etc.; Five, bind Baconic, be positioned at articular cavity, lubricated, the connection in main department joint.
Above-mentioned three is keeping coordinating and equilibrated relation in body under the normal physiological state, and when prosperity or situation on the decline appearred among the three any one for a certain reason, people's health will produce pathological disorders.According to Tibetan medicine's theory, the human body that nervus centralis pain is influenced belongs to grand and Baconic's category fully, balance just causes so nervus centralis pain has lost just because of grand, Baconic, therefore, must coordinate to swell and could fundamentally treat nervus centralis pain with Baconic.
Treatment nervus centralis pain medication commonly used at present mainly contains following a few class: the one, and analgesic comprises opium kind analgesics and central nonopioid analgesic, analgesic is alleviating pain effectively, but such medicine has addiction, and use is restricted.The 2nd, antidepressants, take antidepressant drug and help to alleviate some nervus centralis pain, particularly give anti depressant medication and obtain positive effect sometimes the higher patient of more obvious, the depressed questionnaire scoring of emotional responses, but be to use anti-depressant therapy nervus centralis pain not have universality, only be suitable for some nervus centralis pain.The 3rd, anticonvulsant, this type of drug main will be by suppressing unusual synapse conduction and pathologic multi-neuron reflection causing analgesic activity under the cortex, but anticonvulsant has bigger side effect, as the vomiting that causes nausea, liver spleen are impaired, bone marrow depression Thromboasthenia, myocardial toxicity or the like, the serious harm health can not be taken for a long time.
If can adopt the raw material of Chinese medicine medicine as treatment nervus centralis pain medication, the injury meeting to human body reduces a lot relatively so.
Radix Lamiophlomidis Rotatae is the dry herb of dicotyledon Labiatae Radix Lamiophlomidis Rotatae Lamiophlomis rotata (Benth.) Kudo., and excavate latter stage in autumn, cleans, and dries.Its property is sweet, bitter, flat.Often be born in high mountain rubble beach, flood land or the stone matter grassy marshland of height above sea level 3900-5100m, be distributed in highlandss such as Tibet, Qinghai, Sichuan, Gansu.Have promoting blood circulation and hemostasis, wind-expelling pain-stopping effect, cure mainly diseases such as traumatic injury, traumatic hemorrhage, rheumatic arthralgia, grasserie, fracture, lumbar strain.
Herba Oxytropis Kansuensis is the dry herb of leguminous plant Herba Oxytropis falcatae Oxytropis falcata Bunge and Herba Oxytropis chiliophyllae Oxytropis falcataBunge.Excavate herb at the beginning of autumn late summer, clean earth, Ex-all is assorted takes out, and dries.Herba Oxytropis Kansuensis is the common plant in HOh Xil.Gas is different, mildly bitter flavor.Have the heal effect of skin ulcer, hesitant pulse hemostasis, relieving constipation of heat-clearing and toxic substances removing, granulation promoting, cure mainly epidemic disease, toxonosis, grasserie, constipation, diseases such as anthrax.
Rhizoma Curcumae Longae is a zingiberaceous plant Rhizoma Curcumae Longae Curcuma Longa L. rhizome.Excavate when stem and leaf is withered winter, cleans, and boils or steam to the saturating heart, dries, and removes fibrous root.Main product Sichuan, Fujian, Guangdong, Jiangxi, its property suffering, hardship, temperature are returned spleen, Liver Channel.Has the removing blood stasis circulation of qi promoting, the effect of inducing menstruation to relieve menalgia.Cure mainly diseases such as the breast side of body twinges, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.
Pericarpium Zanthoxyli is the dry mature skin of rutaceae green pepper Zanthoxylum schinifolium Sieb.etZucc. or Pericarpium Zanthoxyli Zanthoxylumbungeanum Maxim..The mature fruit of gathering autumn is dried, and removes seed and impurity, its property suffering, temperature.Return spleen, stomach, kidney channel.Be born in the bushes of hillside or on the sunny side, the roadside.Main product Sichuan, Shaanxi, Hebei.Have warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching cures mainly that coldness and pain in the epigastrium, vomiting are had loose bowels, diseases such as abdominal pain due to worm stagnation, ascariasis, eczema pruritus.
Cornu Bubali is the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.After getting the angle, decocting in water is except that chamfering plug, drying.Its hardship is salty, cold, goes into the heart, liver, spleen, stomach four warps.Have heat clearing away, removing heat from blood, Detoxication.Cure mainly calentura headache, high fever coma, macule, tell diseases such as nosebleed, infantile convulsion, sore throat pharyngeal swelling.
Cacumen Myricariae Germanicae is plant Cacumen Myricariae Germanicae Myricaria germanica (L.) Desv. of Cacumen Tamaricis section and the dry twig that belongs to several plants together, is used as medicine with sprout.Gather spring and summer, and the clip twig dries.Its property is puckery, sweet, cold.Be distributed in Hubei the east of Sichuan, Zigui and Wushan, Sichuan, be born in low bank, the mountains and rivers and roadside.Have heat-clearing and toxic substances removing, disperse the effect of rash, cure mainly diseases such as measles without adequate eruption, laryngopharynx swelling and pain, nosotoxicosis, grasserie, heat in blood disease, pestilence epidemic disease, internal organs be scorchingly hot.
Flos Carthami is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Summer flower is plucked when red by xanthochromia, dries in the shade or dries.Its property suffering, temperature, GUIXIN, Liver Channel.Have promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing cures mainly diseases such as amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.
Borneolum Syntheticum is that the resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum extracts the crystallization that obtains, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.Its property is arduous, cool, GUIXIN, lung meridian.It can be used for being used for the excess syndrome of stroke coma, is used for conjunctival congestion and swelling pain, the sore throat aphtha, is used for skin infection and swells and ache, and does not hold back after bursting etc.
Camphora is a kind of cyclohexane extraction monoterpene derivative, from the ketone that bark and the wooden distillation of Lignum cinnamomi camphorae makes, and also can be synthetic from Oleum Terebinthinae.Its property suffering, heat, poisonous.GUIXIN, spleen channel.Effect dehumidifying parasite killing, warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Cure mainly scabies pruritus, traumatic pain, toothache.
In the prior art, Chinese patent literature CN1709445 discloses Tibetan medicine of a kind for the treatment of acute and chronic bruise, rheumatism, rheumatoid disease and preparation method thereof, and its crude drug is made up of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, Cacumen Myricariae Germanicae.Another Chinese patent literature CN101574505A discloses a kind of Tibetan medicine aerosol for the treatment of acute and chronic bruise, rheumatism, rheumatoid disease, its crude drug is to add Flos Carthami, Borneolum Syntheticum and Camphora on the basis of the crude drug of above-mentioned patent documentation CN1709445, promptly is made up of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, Cacumen Myricariae Germanicae, Flos Carthami, Borneolum Syntheticum, Camphora.Above-mentioned two kinds of Tibetan medicine compositionss have the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Above-mentioned two kinds of Tibetan medicine compositionss only are used for the treatment of acute and chronic bruise, rheumatism, rheumatoid disease at present, and have peripheroneural analgesic activity, and do not find the application of above-mentioned Tibetan medicine compositions in preparation treatment nervus centralis pain medication.
Summary of the invention
The object of the present invention is to provide a kind of application of Tibetan medicine compositions known in the state of the art.
For achieving the above object, the present invention is by the following technical solutions:
The application of a kind of Tibetan medicine compositions in preparation treatment nervus centralis pain medication, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part.
Described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part.
Described Tibetan medicine compositions is made up of following bulk drugs: 10 parts of Radix Lamiophlomidis Rotataes, 5 parts of Herba Oxytropis Kansuensiss, 30 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 10 parts of Cornu Bubalis, 30 parts of Cacumen Myricariae Germanicaes.
Described Tibetan medicine compositions is made up of following bulk drugs: 12 parts of Radix Lamiophlomidis Rotataes, 4 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 10 parts in Pericarpium Zanthoxyli, 11 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes.
Described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
The application of a kind of Tibetan medicine compositions in preparation treatment nervus centralis pain medication, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part.
Described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part, Flos Carthami 0.5-2 part, Borneolum Syntheticum 0.2-4 part, Camphora 0.2-4 part.
Described Tibetan medicine compositions is made up of following bulk drugs: 9.1 parts of Radix Lamiophlomidis Rotataes, 4.5 parts of Herba Oxytropis Kansuensiss, 40.9 parts in Rhizoma Curcumae Longae, 13.6 parts in Pericarpium Zanthoxyli, 9.1 parts of Cornu Bubalis, 22.7 parts of Cacumen Myricariae Germanicaes, 1.8 parts on Flos Carthami, 2 parts of Borneolum Syntheticums, 2 parts of Camphoras.
Described Tibetan medicine compositions is made up of following bulk drugs: 7 parts of Radix Lamiophlomidis Rotataes, 6 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 8 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes, 1 part on Flos Carthami, 0.5 part of Borneolum Syntheticum, 0.5 part of Camphora.
Described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
The Tibetan medicine thinks that all neural wounds all belong to hot, is because of blood and red crust disorder, and pathogenic heat is invaded due to the sering, shows as symptoms such as body heat severe pain, facial hemiparalysis, obnubilation.Therefore, control and to press down wind and transfer grand.Consciousness-restoring and orifice-opening, channels sootheing and network vessel quickening, heat clearing and damp drying reduce phlegm etc.Tibetan medicine compositions described in the present invention has the effect of blood circulation promoting and blood stasis dispelling.This Tibetan medicine prescription is that the doctor among the people of Tibetan is carried, and formed in conjunction with the practical experience prescription according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " two secretaries.The natural quality authentic medicinal herbs is produced in raw materials used medicine polyphyly Qinghai-Tibet Platean, concocts according to the Tibetan medicine theory provision.Radix Lamiophlomidis Rotatae has promoting blood circulation and hemostasis, wind-expelling pain-stopping, holds back effects such as yellow fluid in the side; Cornu Bubali has heat clearing away, removing heat from blood, Detoxication, cures mainly the calentura headache; Herba Oxytropis Kansuensis has heat-clearing and toxic substances removing, the granulation promoting effects such as skin ulcer, hesitant pulse hemostasis that heal; Rhizoma Curcumae Longae has the removing blood stasis circulation of qi promoting in the side, the effect of inducing menstruation to relieve menalgia; Pericarpium Zanthoxyli has warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching.Have that each single medicinal material is this pharmaceutical composition plays good action at the treatment central pain a material base in the side of these effects.Especially the collaborative pharmacological action of Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali and Cacumen Myricariae Germanicae, thereby can nurse one's health grand, Baconic gradually by medicine, further recover the physiological function of patient's nerve, can reach the effect for the treatment of both the principal and secondary aspects of a disease to treatment nervus centralis pain.
Technique scheme of the present invention has the following advantages compared to existing technology:
The present invention is by having discovered further that to the pharmacology of the disclosed Tibetan medicine compositions of patent documentation CN1709445 in the prior art this Tibetan medicine compositions has very strong analgesia and therapeutical effect to the maincenter neuropathic pain.Simultaneously, further finding after further adding Flos Carthami, Borneolum Syntheticum and Camphora on the basis of above-mentioned Tibetan medicine composition component, equally the maincenter neuropathic pain to be had very strong analgesia and therapeutical effect in the research.In addition, adopt the Qinghai-Tibet Platean to produce the natural crude drugs of pure natural in these two kinds of Tibetan medicine compositionss, do not add the stabilizing agent of any chemosynthesis, human body is not had toxic and side effects, safety, effective is applicable to all kinds of crowds, is suitable for treating various nervus centralis pain.
The specific embodiment
Embodiment 1
The preparation of powder
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 5 weight portions, Herba Oxytropis Kansuensis 2 weight portions, Rhizoma Curcumae Longae 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Cornu Bubali 5 weight portions, Cacumen Myricariae Germanicae 15 weight portions;
Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Pericarpium Zanthoxyli, Cornu Bubali, the selection of Cacumen Myricariae Germanicae medical material of above-mentioned specified weight part is standby, the above-mentioned raw materials medicine is made the superfine powder of 1-10 μ m through superfine communication technique, make powder.
Embodiment 2
The preparation of capsule
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 8 weight portions, Herba Oxytropis Kansuensis 3 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 20 weight portions, Flos Carthami 0.5 weight portion, Borneolum Syntheticum 0.2 weight portion, Camphora 0.2 weight portion;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami of all the other specified weight parts are mixed, after it is pulverized, water with 10 times of medical material weight decocts it, decoct and extract 3 times, each 1 hour, collect afterwards and merge above-mentioned three extracting solution, it is that 1.25 extractum is standby that extracting solution is condensed into relative density; In the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-25 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 16 hours, mixture after freezing is pulverized, and the Camphora, Borneolum Syntheticum and an amount of starch, sodium carboxymethyl cellulose, the carboxymethyl starch sodium granulation that add above-mentioned specified weight part, filling, packing promptly get capsule.
Embodiment 3
The preparation of granule
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is:
Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions, Flos Carthami 1.8 weight portions, Borneolum Syntheticum 2.0 weight portions, Camphora 2.0 weight portions;
Pericarpium Zanthoxyli with above-mentioned specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-200 μ m, to all the other specified weight parts through remove impurity, clean, dried Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami mixing also is ground into coarse powder, 75% ethanol with 8 times of above-mentioned mixing medical material weight extracts 3 times above-mentioned mixing medical material, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.20 extractum that extracting solution is condensed into relative density, in the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali fine powder, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-40 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 12 hours, mixture after freezing is pulverized, the Borneolum Syntheticum and the Camphora that add above-mentioned specified weight part mix and add an amount of starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium is granulated, and makes granule.
Embodiment 4
The preparation of tablet
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 15 weight portions, Herba Oxytropis Kansuensis 10 weight portions, Rhizoma Curcumae Longae 60 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 15 weight portions, Cacumen Myricariae Germanicae 40 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material of all the other specified weight parts are mixed, after it is pulverized, water with 20 times of medical material weight decocts it, decoct and extract 2 times, the each extraction 2 hours collected and merge extractive liquid, afterwards, and it is 1.15 extractum that extracting solution is condensed into relative density, the water that reuse extractum volume is 7 times dilutes it, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 10 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 20% washing with alcohol, resolve with 50% ethanol at last; Desorbed solution is reclaimed ethanol to there not being the alcohol flavor, concentrate, spray drying, obtain extract dry powder, and this extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder mix homogeneously again, make the superfine powder of 0.1-1 μ m through superfine communication technique, add starch, sodium carboxymethyl cellulose, carboxymethyl starch sodium granulation in above-mentioned superfine powder, add the Pulvis Talci mix homogeneously again, tabletting, packing promptly get tablet.
Embodiment 5
The preparation of pill
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 15 weight portions, Herba Oxytropis Kansuensis 10 weight portions, Rhizoma Curcumae Longae 60 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 15 weight portions, Cacumen Myricariae Germanicae 40 weight portions, Flos Carthami 2.5 weight portions, Borneolum Syntheticum 5 weight portions, Camphora 5 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by, Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami to all the other specified weight parts mix and pulverizing, 50% ethanol with 15 times of above-mentioned mixing medical material weight extracts 2 times above-mentioned mixing medical material, each 2h that extracts, collect afterwards and merge above-mentioned extracted twice liquid, it is 1.25 extractum that extracting solution is condensed into relative density, the water that reuse extractum volume is 5 times dilutes it, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 7 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 60% ethanol at last; Desorbed solution is reclaimed ethanol to there not being the alcohol flavor, concentrate, lyophilization, obtain extract dry powder, and this extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli, Cornu Bubali fine powder again, mix homogeneously, make the superfine powder of 1-10 μ m through superfine communication technique, the Borneolum Syntheticum, the Camphora that add above-mentioned specified weight part in above-mentioned superfine powder mix, and add the debita spissitudo hydromel and make pill.
Embodiment 6
The preparation of soft capsule
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 10 weight portions, Herba Oxytropis Kansuensis 5 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 15 weight portions, Cornu Bubali 10 weight portions, Cacumen Myricariae Germanicae 30 weight portions;
Pericarpium Zanthoxyli with above-mentioned specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-200 μ m, the Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and pulverizes, vinegar (total acid 〉=3.5g/100ml acetic acid) with 6 times of medical material weight soaked 7 days, after medical material is fully expanded, place percolator, percolate is slowly flowed out, collect percolate, reclaiming solvent, to get relative density be 1.15 extractum, the Pericarpium Zanthoxyli that in above-mentioned extractum, adds above-mentioned specified weight part again, the Cornu Bubali fine powder stirs evenly the back to wherein adding the certain proportion gelatin, glycerol, water etc. are made soft capsule.
Embodiment 7
The preparation of spray
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 13 weight portions, Herba Oxytropis Kansuensis 8 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 13 weight portions, Cacumen Myricariae Germanicae 35 weight portions, Flos Carthami 2.0 weight portions, Borneolum Syntheticum 4.0 weight portions, Camphora 4.0 weight portions;
Adjuvant is: polyvidone 6 weight portions, glycerol 2 weight portions, tween 80 9 weight portions, tetrafluoroethane 30 weight portions;
It is stand-by that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m superfine powder; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and it are pulverized, with 70% ethanol of 10 times of above-mentioned mixing medical material weight to mixing medicinal material extract 3 times, the each extraction 0.5 hour, collect afterwards and merge above-mentioned three extracting solution, it is that 1.15 extractum is standby that extracting solution is condensed into relative density; Again that Borneolum Syntheticum, Camphora, glycerol, Tween 80, the polyvidone of above-mentioned specified weight part is standby with 60% dissolve with ethanol.Above-mentioned solution and extractum and the Pericarpium Zanthoxyli after micronizing, Cornu Bubali are merged, add ethanol and make and contain the alcohol amount in the mixed liquor and be 40%-50%, make 1000ml altogether, mixing, static, filter the back filling and sealing and get final product.
Embodiment 8
The preparation of ointment
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 12 weight portions, Herba Oxytropis Kansuensis 4 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 11 weight portions, Cacumen Myricariae Germanicae 25 weight portions;
It is stand-by that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m superfine powder; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and it is pulverized, with 75% ethanol of 8 times of above-mentioned mixing medical material weight to mixing medicinal material extract 3 times, each 1h, collect afterwards and merge above-mentioned three extracting solution, it is 1.15 extractum that extracting solution is condensed into relative density, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali superfine powder, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-40 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 24 hours, mixture after freezing is pulverized, and to wherein adding an amount of glycerol, polyoxyethylene sorbitan monoleate mixes, and is heated to 80 degrees centigrade as water; With liquid paraffin, span mix homogeneously, be heated to 80 degrees centigrade as oil phase; Then that oil phase is mixed with water, below the restir to 37 degree centigrade, go out cream, fill, packing is promptly.
Embodiment 9
The preparation of gel
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 7 weight portions, Herba Oxytropis Kansuensis 6 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 15 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 25 weight portions, Flos Carthami 1 weight portion, Borneolum Syntheticum 0.5 weight portion, Camphora 0.5 weight portion;
Pericarpium Zanthoxyli with specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-200 μ m, the Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mixes and pulverizes, vinegar (total acid 〉=3.5g/100ml acetic acid) with 10 times of above-mentioned mixing medical material weight soaked 2 days, after medical material is fully expanded, place percolator, percolate is slowly flowed out, collect percolate, reclaiming solvent, to get relative density be 1.30 extractum, the Pericarpium Zanthoxyli that in above-mentioned extractum, adds above-mentioned specified weight part again, Cornu Bubali fine powder and Camphora, Borneolum Syntheticum mixes, add an amount of carbomer again, glycerol, propylene glycol, triethanolamine and suitable quantity of water, mixing and stirring, filling and package are promptly.
Embodiment 10
The preparation of rubber-emplastrum
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 8 weight portions, Herba Oxytropis Kansuensis 3 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 8 weight portions, Cacumen Myricariae Germanicae 20 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of specified weight part is broken into 0.01-50 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the Cacumen Myricariae Germanicae medical material mixes and pulverizes, water with 10 times of above-mentioned mixing medical material weight decocts and extracts it 3 time, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.25 extractum that extracting solution is condensed into relative concentration, add above-mentioned Pericarpium Zanthoxyli, the Cornu Bubali fine powder is reduced to room temperature and this mixture is put into the aluminum dish, and described aluminum dish is put into the vacuum freezing storehouse after stirring evenly, the temperature in described vacuum freezing storehouse is reduced temperature to-30 ℃, be provided with its internal vacuum for (＜10Pa), the taking-up that opens a position after 24 hours is pulverized the mixture after freezing, and to wherein adding natural rubber, zinc oxide, lanoline, liquid paraffin is made rubber-emplastrum, coating, cut, packing, packing is promptly.
Embodiment 11
The preparation of cataplasma
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 5 weight portions, Herba Oxytropis Kansuensis 2 weight portions, Rhizoma Curcumae Longae 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Cornu Bubali 5 weight portions, Cacumen Myricariae Germanicae 15 weight portions, Flos Carthami 0.1 weight portion, Borneolum Syntheticum 0.1 weight portion, Camphora 0.1 weight portion;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, flos carthami mix and pulverize, water with 8 times of above-mentioned mixing medical material weight decocts and extracts it 2 time, each 1h that extracts, reclaiming solvent, to get relative density be 1.20 extractum, the water that reuse extractum volume is 8 times dilutes it, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate, vacuum drying (0.08MPa), after the gained extract dry powder is ground into fine powder, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali fine powder, mix homogeneously, make the superfine powder of 0.01-50 μ m through superfine communication technique, the Borneolum Syntheticum that in above-mentioned superfine powder, adds above-mentioned specified weight part, Camphora and sodium polyacrylate 3 weight portions, gelatin 1 weight portion, glycerol 14 weight portions, propylene glycol 7 weight portions, dihydroxyaluminum aminoacetate 0.2 weight portion, methyl hydroxybenzoate 0.2 weight portion, butoben 0.2 weight portion and 50 weight parts waters mix, stir coating, lid lining, cut, packing promptly gets cataplasma.
Embodiment 12
The preparation of slow releasing preparation
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 13 weight portions, Herba Oxytropis Kansuensis 8 weight portions, Rhizoma Curcumae Longae 30 weight portions, Pericarpium Zanthoxyli 20 weight portions, Cornu Bubali 13 weight portions, Cacumen Myricariae Germanicae 35 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; The Radix Lamiophlomidis Rotatae of all the other specified weight parts, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae medical material mix and pulverize, with 75% ethanol of 8 times of amounts of medical material weight to above-mentioned mixing medicinal material extract 2 times, each 1h that extracts, reclaiming solvent, to get relative density be 1.20 extractum, the dilution of the water of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate vacuum drying, after the gained extract dry powder is ground into fine powder, add stand-by Pericarpium Zanthoxyli, Cornu Bubali fine powder again, mix homogeneously, make the superfine powder of 0.01-0.1 μ m through superfine communication technique, add hydroxypropyl emthylcellulose and lactose in mortar, its mixing, add 80% alcoholic solution system soft material, cross 18 mesh sieves and granulate, wet granular is 50-60 ℃ of drying, dried granule is through 16 mesh sieve granulate, and weighing adds magnesium stearate, mixing, tabletting, encapsulation promptly.
Embodiment 13
The preparation of powder nose inhalant
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is: Radix Lamiophlomidis Rotatae 12 weight portions, Herba Oxytropis Kansuensis 4 weight portions, Rhizoma Curcumae Longae 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Cornu Bubali 11 weight portions, Cacumen Myricariae Germanicae 25 weight portions, Flos Carthami 2.5 weight portions, Borneolum Syntheticum 1.0 weight portions, Camphora 1.0 weight portions;
The fine powder that Pericarpium Zanthoxyli, the Cornu Bubali powder of above-mentioned specified weight part is broken into 0.01-200 μ m is stand-by; Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, Cacumen Myricariae Germanicae, the flos carthami of all the other specified weight parts are mixed, pulverize, with 75% ethanol extraction of 8 times of above-mentioned mixing medical material weight 2 times, each 1h that extracts, collect afterwards and merge above-mentioned extracted twice liquid, it is 1.20 extractum that extracting solution is condensed into relative density, the water dilution of 8 times of amounts of reuse extractum volume, filter the clarification extracting solution; With the clarification extracting solution feed absorption, washing, the flow velocity of resolving is 6 times of bed volumes/hour macroporous adsorptive resins, wash with water earlier, again with 30% washing with alcohol, resolve with 75% ethanol at last; Desorbed solution is reclaimed ethanol, concentrate, vacuum drying, obtain extract dry powder, and this extract dry powder is ground into fine powder, add Borneolum Syntheticum, the Camphora of above-mentioned specified weight part, add Pericarpium Zanthoxyli, Cornu Bubali fine powder mix homogeneously again, add an amount of insoluble support MCC and bioadhesive polymers H-HPC, adopt grinding and freeze drying process to prepare powder spray, encapsulation promptly.
Embodiment 14
The preparation of slow-release paster
The crude drug that can be used for treating the Tibetan medicine compositions of nervus centralis pain of the present invention is:
Radix Lamiophlomidis Rotatae 9.1 weight portions, Herba Oxytropis Kansuensis 4.5 weight portions, Rhizoma Curcumae Longae 40.9 weight portions, Pericarpium Zanthoxyli 13.6 weight portions, Cornu Bubali 9.1 weight portions, Cacumen Myricariae Germanicae 22.7 weight portions;
Pericarpium Zanthoxyli with above-mentioned specified weight part, it is stand-by that Cornu Bubali powder is broken into the fine powder of 0.01-50 μ m, to all the other specified weight parts through remove impurity, clean, dried Radix Lamiophlomidis Rotatae, Herba Oxytropis Kansuensis, Rhizoma Curcumae Longae, the mixing of Cacumen Myricariae Germanicae medical material also is ground into coarse powder, 70% ethanol with 10 times of above-mentioned mixing medical material weight extracts 3 times above-mentioned mixing medical material, each 1.5h, collect afterwards and merge above-mentioned three extracting solution, it is 1.15 extractum that extracting solution is condensed into relative density, in the extractum that obtains, add above-mentioned Pericarpium Zanthoxyli again, the Cornu Bubali fine powder, reduce to room temperature after stirring evenly and this mixture is put into the aluminum dish, and described aluminum dish put into the vacuum freezing storehouse, the temperature in described vacuum freezing storehouse is reduced to-30 ℃, be provided with its internal vacuum for (＜10Pa), taking-up opened a position after 16 hours, mixture after freezing is pulverized, add the dense thick liquid of gelatin (getting gelatin adding distil water heated and stirred) to even dense thick liquid, polyvinylpyrrolidone, Mentholum stirs, and makes slow-release paster.
As the distortion of the foregoing description, described Tibetan medicine compositions can be the arbitrary dosage form in pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, sublimed preparation, injection, cream, spray, drop pill, unguentum, ointment, cataplasma, gel, liniment, resin subsides, patch, slow releasing preparation, controlled release preparation or the freeze-dried powder preparation.
Experimental example
In order to show that above-mentioned two kinds of Tibetan medicine compositionss have the obvious treatment effect when being used for preparation treatment nervus centralis pain medication, the present invention has carried out record to the clinical use of said medicine:
1 case is selected
1.1. diagnostic criteria
1.1.1 have central nervous system disease, pathological changes and dysfunction may be positioned at neuroaxonal any level;
1.1.2 this disease incidence begins pain later on, time of occurrence is indefinite, immediately or postpone, pain may be persistence, intermittently paroxysmal or be to occur with hyperpathia;
1.1.3 pain can occur with different character, at same position or zones of different usually can experience the pain of more than one character;
1.1.4 the intensity of pain or high or low, various interior external stimuluss often can bring out pain;
1.1.5 exist somesthesia unusual, show as unusual pain, hyperpathia or paraesthesia, touch the thing pain;
1.1.6 non-sensualness nervous symptoms and sign also can exist or not exist.Therefore, it doesn't matter between central neuralgia and the movement disorder;
1.1.7 the obstacle of psychology and spirit can exist or not exist.The neuralgic patient of most of centrals is normal in these areas;
1.1.8 pain should not be construed spiritual source;
1.1.9 the neuralgic diagnosis of some central should determine according to clinical settings and diagnostic criteria, by means of lab testing and CT, MRI etc., is not to be the nociception type or to originate from peripheral nerve to differentiate this pain.
1.2 the standard of including in
1.2.1 meet the neuralgic diagnostic criteria of above-mentioned neutrality;
1.2.2 durante dolors must be more than 3 months;
1.2.3 clinical trial should first-selected moderate (VAS＞=40mm or NRS＞=4), severe pain patient;
1.2.4 the age is in 25-80 year;
1.2.5 voluntary accepting treatment, observation and inspection and signature informed consent person.
1.3 exclusion standard
1.3.1 with depression;
1.3.2 irrelevant with neuropathy pain, as may to disturb the pain assessment obvious nerve and mental disorder;
1.3.3 may disturb other serious pain of neuropathy pain assessment;
1.3.4 the disease patient with mixed type pain should be left out in the authenticity test.
1.4 therapeutic evaluation
Main curative effect index: visual analogue scale (visualanalogous scale VAS scoring);
Secondary efficacy index: onset time and pain relieving persistent period;
Preceding visual simulation scale (VAS) the score value difference that reaches treatment 2,4,8 all footline VAS scales scorings and treatment front and back of treatment compares.
1.5 patient grouping and respectively organize medication: (will be and intermediate value do experiment example) at the two ends of component
1.5.1 grouping: in August, the 2006～2,010 280 routine nervus centralis pain-suffered patients (patient who comprises pain after Spinal Cord Injury and post-stroke pain) that I institute accept for medical treatment, make a definite diagnosis year January are divided into 1-14 group, 30～70 years old age at random; The course of disease 2～JIUYUE.The above-mentioned 1-14 group age and the preceding course of disease of going to a doctor are checked P＜0.01 through t.
1.5.2 it is as follows respectively to organize Therapeutic Method:
In above-mentioned 14 groups, the 1-13 group is the treatment group of the Tibetan medicine compositions among the present invention, and the 14th group is matched group.
The 1st group: with the granule (every bag 6 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 3 methods, each oral 1 bag, every day 1-2 time.
The 2nd group: with the soft capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 6 methods, each oral 4, every day 1-2 time.
The 3rd group: with the pill (every ball 0.2 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 5 methods, each oral 8 balls, every day 1-2 time.
The 4th group: with the powder (every bag 5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 1 method, each oral 2.5g, every day 1-2 time.
The 5th group: with the cataplasma (every subsides 10 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 11 methods, spread on painful area, paste every day 1.
The 6th group: with the rubber-emplastrum (every subsides 5 grams) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 10 methods, spread on painful area, paste every day 1.
The 7th group: with the slow releasing preparation (every slice 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 12 methods, each oral 3, every day 1 time.
The 8th group: with the tablet (every slice 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 4 methods, each oral 3, every day 1-2 time.
The 9th group:, be applied in painful area, every day 1-2 time with the ointment (every 20 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 8 methods.
The 10th group:, be sprayed on painful area, every day 3-5 time with the spray (every bottle 50 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 7 methods.
The 11st group:, be applied in painful area, every day 1-2 time with the gel (every bottle 5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 9 methods.
The 12nd group: with the slow-release paster (every subsides 5mg gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 14 methods, spread on painful area, 1-2 pastes weekly.
The 13rd group: with the capsule (every 0.5 gram) of the Tibetan medicine compositions among the present invention according to the preparation of embodiment 2 methods, each oral 4, every day 1-2 time.
The 14th group (matched group): the oral carbamazepine of by specification (Diao Group Chengdu Pharmaceutical Co., Ltd.).
1.6 curative effect determinate standard:
| Recovery from illness | Primary symptom and simultaneous phenomenon disappear |
| Produce effects | Primary symptom and simultaneous phenomenon partly disappear (primary symptom integration reduce＞60%) |
| Effectively | Primary symptom and/or simultaneous phenomenon alleviate (the primary symptom integration reduces 0～59%) |
| Invalid | Primary symptom and/or simultaneous phenomenon no change (the primary symptom integration reduces 0%) |
Computing formula: (nimodipine method) is: [integration before VAS (integration before the treatment-treatment back integration) the ÷ treatment] * 100%
2, statistical method
EPIdata software is adopted in data management; Statistical analysis adopts the SPASS12.0 statistical package to carry out analyzing and processing.Constituent ratio is with the t check between two groups, two groups of means relatively with the t check, curative effect is relatively used Ridit between two groups.The P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.
3, therapeutic outcome
1-13 group (treatment group) is all carried out Drug therapy front and back VAS scoring difference with the 14th group (matched group) check P＜0.01 through t.Tibetan medicine compositions 1-13 group total effective rate of the present invention is respectively 77.78%, 80.00%, 81.82%, 73.68%, 80.95%, 77.78%, 80.00%, 72.22%, 81.82%, 82.60%, 80.00%, 83.33%, 75.00%, the carbamazepine effective percentage is 52.38%, P＜0.01 is analysed in credit by statistics statistical significance, the treatment group all is better than matched group, t checks P＜0.01, influences such as no liver, renal function.The results are shown in Table 1:
Table 1 Drug therapy nervus centralis of the present invention pain result
Tibetan medicine compositions 1-13 group curative effect of the present invention obviously is better than matched group (P＜0.01).
4, untoward reaction
The treatment group is during treating, and obvious adverse reaction does not all take place all experimenters.
5, discuss:
(central pain CP) is meant brain or the relevant neuropathic pain of diseases of spinal cord that a class and a variety of causes cause to central pain, is the most thorny a kind of pain syndrome.Be divided into pain after Spinal Cord Injury (spinal cord injury pain anatomically, SCIP) and post-stroke pain (centralpost-stroke pain, CPSP), the sings and symptoms of both performances may be fully different, and modal reason is vascular conditions, injures demyelination outward.Tibetan medicine compositions of the present invention all can reduce the reaction of posterior horn of spinal cord immunoreactive positive neurons to the noxious stimulation that imports into, thereby the unlatching that suppresses pain sensation valve is to ease the pain, its analgesic effect that has can be used as the neuropathic pain patient that the treatment maincenter causes, and can be used as the neuropathic pain patient's that the treatment maincenter causes active drug.Tibetan medicine compositions of the present invention is traditional Tibetan medicine, its major function cures mainly and is blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, show by above clinical research result the treatment central pain, Tibetan medicine compositions 1-13 group of the present invention has good analgesic effect to central pain respectively, total effective rate is respectively 77.78%, 80.00%, 81.82%, 73.68%, 80.95%, 77.78%, 80.00%, 72.22%, 81.82%, 82.60%, 80.00%, 83.33%, 75.00%, curative effect is better than carbamazepine matched group 52.38%, P＜0.01 is analysed in credit by statistics statistical significance, and the treatment group all is better than matched group.
By above the clinical research result of Tibetan medicine compositions described in the present invention to the treatment of maincenter neuropathic pain shown, Tibetan medicine compositions of the present invention can reduce the reaction of posterior horn of spinal cord immunoreactive positive neurons to the noxious stimulation that imports into, thereby the unlatching that suppresses pain sensation valve is to ease the pain, and it has obvious analgesic activity.In addition, described Tibetan medicine compositions without any side effect, uses patient's the safety of its treatment good to human body.Therefore, Tibetan medicine compositions of the present invention can be used as the neuropathic pain patient's that the treatment maincenter causes active drug.
Method according to above-mentioned test example has all been carried out clinical trial to the Tibetan medicine compositions of above-mentioned all embodiment preparations, and its result of the test shows that the Tibetan medicine compositions among the present invention all has better curative effect to treatment central neuralgia.
Obviously, the foregoing description only is for example clearly is described, and is not the qualification to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here need not also can't give exhaustive to all embodiments.And conspicuous variation of being extended out thus or change still are among the protection domain of the invention.
Claims (10)
1. the application of Tibetan medicine compositions in preparation treatment nervus centralis pain medication, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part.
2. application according to claim 1 is characterized in that, described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part.
3. application according to claim 1 is characterized in that, described Tibetan medicine compositions is made up of following bulk drugs: 10 parts of Radix Lamiophlomidis Rotataes, 5 parts of Herba Oxytropis Kansuensiss, 30 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 10 parts of Cornu Bubalis, 30 parts of Cacumen Myricariae Germanicaes.
4. application according to claim 1 is characterized in that, described Tibetan medicine compositions is made up of following bulk drugs: 12 parts of Radix Lamiophlomidis Rotataes, 4 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 10 parts in Pericarpium Zanthoxyli, 11 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes.
5. according to the arbitrary described application of claim 1-4, it is characterized in that described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
6. the application of Tibetan medicine compositions in preparation treatment nervus centralis pain medication, wherein said Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 5-15 part, Herba Oxytropis Kansuensis 2-10 part, Rhizoma Curcumae Longae 15-60 part, Pericarpium Zanthoxyli 7-20 part, Cornu Bubali 5-15 part, Cacumen Myricariae Germanicae 15-40 part, Flos Carthami 0.1-2.5 part, Borneolum Syntheticum 0.1-5 part, Camphora 0.1-5 part.
7. application according to claim 6, it is characterized in that described Tibetan medicine compositions is made up of following bulk drugs: Radix Lamiophlomidis Rotatae 8-13 part, Herba Oxytropis Kansuensis 3-8 part, Rhizoma Curcumae Longae 20-30 part, Pericarpium Zanthoxyli 10-20 part, Cornu Bubali 8-13 part, Cacumen Myricariae Germanicae 20-35 part, Flos Carthami 0.5-2 part, Borneolum Syntheticum 0.2-4 part, Camphora 0.2-4 part.
8. application according to claim 6, it is characterized in that described Tibetan medicine compositions is made up of following bulk drugs: 9.1 parts of Radix Lamiophlomidis Rotataes, 4.5 parts of Herba Oxytropis Kansuensiss, 40.9 parts in Rhizoma Curcumae Longae, 13.6 parts in Pericarpium Zanthoxyli, 9.1 parts of Cornu Bubalis, 22.7 parts of Cacumen Myricariae Germanicaes, 1.8 parts on Flos Carthami, 2 parts of Borneolum Syntheticums, 2 parts of Camphoras.
9. application according to claim 6, it is characterized in that described Tibetan medicine compositions is made up of following bulk drugs: 7 parts of Radix Lamiophlomidis Rotataes, 6 parts of Herba Oxytropis Kansuensiss, 20 parts in Rhizoma Curcumae Longae, 15 parts in Pericarpium Zanthoxyli, 8 parts of Cornu Bubalis, 25 parts of Cacumen Myricariae Germanicaes, 1 part on Flos Carthami, 0.5 part of Borneolum Syntheticum, 0.5 part of Camphora.
10. according to the arbitrary described application of claim 6-9, it is characterized in that described Tibetan medicine compositions is pill, tablet, capsule, oral liquid, syrup, granule, soft capsule, powder, unguentum, sublimed preparation, injection, cream, spray, drop pill, cataplasma, gel, liniment, patch, slow releasing preparation, controlled release preparation or freeze-dried powder preparation.
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| CN2010105936908A CN102058848A (en) | 2010-12-17 | 2010-12-17 | Application of Tibetan medicine composition to preparation of medicine for treating central neuropathic pains |
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| CN2010105936908A CN102058848A (en) | 2010-12-17 | 2010-12-17 | Application of Tibetan medicine composition to preparation of medicine for treating central neuropathic pains |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638444A (en) * | 2012-12-20 | 2014-03-19 | 浙江农林大学 | Effective part of cheezheng pain relieving plaster and preparation method therefor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709445A (en) * | 2005-07-06 | 2005-12-21 | 甘肃奇正藏药有限公司 | Tibetan medicine for major functions of acute-chronic sprain-contusion, rheumatism, rheumatoid diseases, and its preparing method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709445A (en) * | 2005-07-06 | 2005-12-21 | 甘肃奇正藏药有限公司 | Tibetan medicine for major functions of acute-chronic sprain-contusion, rheumatism, rheumatoid diseases, and its preparing method |
Non-Patent Citations (1)
| Title |
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| 《北京中医药大学学报(中医临床版)》 20090330 白桦等 奇正消痛贴外用缓解癌性疼痛的作用及相关机制研究 , 第02期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638444A (en) * | 2012-12-20 | 2014-03-19 | 浙江农林大学 | Effective part of cheezheng pain relieving plaster and preparation method therefor |
| CN103638444B (en) * | 2012-12-20 | 2020-07-14 | 浙江农林大学 | Effective part of Qizheng pain-relieving plaster and its preparation method |
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Application publication date: 20110518 |