CN104984180A - Traditional Chinese medicine combination for treating gout and preparing method thereof - Google Patents
Traditional Chinese medicine combination for treating gout and preparing method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine combination for treating gout and a preparing method thereof. The traditional Chinese medicine combination is prepared from ginseng, radix angelicae sinensis, peach kernels, safflower carthamus, rhizoma smilacis glabrae, yam rhizome, semen coicis, ramulus mori, polygonum cuspidatum, Chinese starjasmine stems and rhizoma dioscoreae nipponicae. The traditional Chinese medicine combination has the effects of activating blood, dissolving stasis, inducing diuresis, discharging acid, dispelling the wind and relieving the pain, can reduce the blood uric acid level of a gout patient, effectively treats red, hot and swollen symptoms caused by muddy stasis and damp evil gout and has an obvious curative effect on the pain when a patient has a gout attack.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of Chinese medicine composition for the treatment of gout and preparation method thereof.
Background technology
Arthromyodynia be because of the damp and hot heresy that is affected by the cold cause with limbs, joint, pain, miserable, numb, to weigh and disease that moving obstacle is cardinal symptom is demonstrate,proved, there is gradual or recurrent exerbation feature clinically.Its main pathogenesis be QI and blood numbness resistance obstructed, muscle arteries and veins joint lose in moisten support caused by.
The name of disease of numbness, sees "Nei Jing" the earliest." Plain Questions numbness opinion " is pointed out: " wet three gas of wind and cold are mixed extremely, combined into numbness, and its migratory BI-syndrome caused mainly by pathogenic wind, BI-syndrome caused mainly by pathogenic cold being called painful BI, the BI syndrome caused mainly by pathogenic dampness being called fixed BI "; " so-called numbness person, respectively with reinfection at that time in the wind and cold person of wetting also." Zhang Jingyue " Jing Yue's complete work numbness " thinks: though arthromyodynia with wind and cold wet full numbness for large then, must point YIN syndrome, YANG syndrome, YANG syndrome is pyretic arthralgia, " have cold person should from warm, have scorching person should from refrigerant ".Wu Ju Tong " in a Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases burnt hygropyrexia " section is thought: arthromyodynia affection of cold person is admittedly many, and the hot person that holds concurrently of numbness is also multiple many, and misapply pungent temperature, its evil is vertical sees.YE Tian shi "guide to clinical practice with medical record" has penetrating discussion for pyretic arthralgia pathogenesis, method for the treatment of: " always arthromyodynia; often cure mainly with the wet three gas random thoughts of wind and cold, call the difference of illness together, because summer-heat excessive pathogenic heat in febrile disease is outer in addition damp and hot; that accumulates in water paddy is damp and hot; external heresy, work is in meridians, and the heresy be inside subject to; work is in venation; therefore pungent solution sweating, pyretic arthralgia does not subtract, entirely bright with anxious clear sun and cause little more." Gu Songyuan " doctor's mirror " then rises, think that pyretic arthralgia not only can be risen by damp and hot heresy of impression, be exactly anemofrigid-damp arthralgia, evil strongly fragrant disease is of a specified duration, and wind becomes fire, and transforming into cold is hot, and wetting and become expectorant, is also pyretic arthralgia.Propose to restore menstrual flow and invigorate blood circulation, to evacuate evil stagnant, the principle for the treatment of of pathogenic fire reducing, heat clearing away, eliminating phlegm.
Western medical treatment gout often adopts the pain relievings such as colchicine, NSAID (non-steroidal anti-inflammatory drug) and glucocorticoid, reduces the medicine of tissue inflammation reaction, or gives to reduce blood uric acid medicine, as probenecid, narcaricin, allopurinol etc.Often cure the symptoms, not the disease, easy recurrent exerbation and side effect is larger.Therapeutic and toxic dose as colchicine medicine is very close, and untoward reaction has nausea,vomiting,diarrhea, liver damage, bone marrow depression and alopecia.
Chinese medicine gout is divided into four types: 1, rheumatism heat-toxin type.Expelling wind and removing dampness, heat clearing away dredging collateral; 2, damp invasion of lower energizer, channels blood stasis blocking type.Clearing away heat-damp and promoting diuresis, disperse blood stasis and dredge collateral; 3, the tight virtual loss of liver, turbid stasis blocking network type.Liver and kidney tonifying, change turbid blood stasis dispelling; 4, deficiency of spleen-YANG and kidneyYANG, cold-damp stasis type.Warming and recuperating the spleen and kidney, removing dampness blood stasis dispelling.Treatment by Chinese herbs gout, side effect is less, and Chinese medicine is more thorough than Western medicine control gout, be reduced to normally at patient's blood uric acid, can continue to break " soil " that patient produces gout, can reduce blood uric acid in acute stage, and the effect of blood uric acid does not fall in the Western medicine usually used in acute stage, mostly can only pain relieving temporarily.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of gout;
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of gout;
Another object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of gout.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of gout of the present invention, it is prepared from by the raw material comprising following weight portion:
Radix Ginseng 4-8 part, Radix Angelicae Sinensis 15-25 part, Semen Persicae 4-8 part, Flos Carthami 4-8 part, Rhizoma Smilacis Glabrae 22-40 part, Rhizoma Dioscoreae Septemlobae 12-18 part, Semen Coicis 12-18 part, Ramulus Mori 10-15 part, Rhizoma Polygoni Cuspidati 10-15 part, Caulis Trachelospermi 10-18 part, Rhizoma Dioscoreae Nipponicae 4-8 part.
Below crude drug source and the primary efficacy of Chinese medicine preparation of the present invention:
Radix Ginseng: be the dry root welding technology of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Excavate more than autumn, clean through drying or drying.Being commonly called as " Park Ginseng " of cultivation; The title " ginseng under forest " of sowing self-sow under mountain forest wild state, practises and claiming in " seed sea ".[nature and flavor with return through] sweet, micro-hardship, tepor.Return spleen, lung, the heart, kidney channel.[function with cure mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood, Fructus Alpiniae Oxyphyllae of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, and prolonged illness void is won, palpitation with fear insomnia, sexual impotence cold womb.
Radix Angelicae Sinensis: be the afterbody of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Radix Angelicae Sinensis and the inclined what of Radix Angelicae Sinensis are invigorated blood circulation, removing blood stasis; The inclined what of Radix Angelicae Sinensis body is enriched blood, is nourished blood.[nature and flavor with return through] sweet, acrid, warm.Return liver, the heart, spleen channel.[function with cure mainly] blood circulation promoting and blood stasis dispelling.For amenorrhea, obstructed and blood stasis stagnates the disease swollen and ache.
Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.[nature and flavor with return through] bitter, sweet, flat.GUIXIN, liver, large intestine channel.[function with cure mainly] blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea dysmenorrhea. WEIJIA mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Pluck when summer, flower was red by xanthochromia, dry in the shade or dry.[nature and flavor with return through] are pungent, temperature.GUIXIN, Liver Channel.[function with cure mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, injury from falling down, skin infection swells and ache.
Rhizoma Smilacis Glabrae: be the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Summer, Qiu Erji excavate, removing fibrous root, cleaning, drying; Or take advantage of fresh-cut flakiness, dry.[nature and flavor with return through] are sweet, light, flat.Return liver, stomach warp.[function with cure mainly] detoxify, dehumidifies, easing joint movement.For the limbs contracture caused by syphilis and mercurialism, bones and muscles pain; Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies.
Rhizoma Dioscoreae Septemlobae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Septemlobae Dioscorea septemloba Thunbt and Dioscoreaceae Plant Powder back of the body Rhizoma Dioscoreae Dioscoreahypoglauca Palibin.[nature and flavor with return through] are bitter, flat.Return kidney, stomach warp.[function with cure mainly] dampness removing goes turbid, wind expelling stagnation removing.For stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.
Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L.var.mayuen (Roman.) Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.[nature and flavor with return through] are sweet, light, cool.Return spleen, stomach, lung meridian.[function with cure mainly] diuretic permeate and wets, and invigorating the spleen to arrest diarrhea, eliminating impediment, arranges dense, detoxicating and resolving stagnation of pathogens.For edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, intestinal carbuncle; Wart, cancerous protuberance.
Ramulus Mori: be the dry twig of moraceae plants Mulberry MorusalbaL..The end of spring and the beginning of summer gathers, defoliation, dries, or takes advantage of fresh slices, dries.[nature and flavor with return through] micro-hardship, flat.Return Liver Channel.[function with cure mainly] wind-damp dispelling, sharp joint.For Bi condition, shoulder arm, joint aches are numb.
Rhizoma Polygoni Cuspidati: be dry rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati Polygonum cuspidatum Sieb.et Zucc..Spring, Qiu Erji excavate, and removing fibrous root, cleans, take advantage of short section of fresh-cut or sheet, dry.[nature and flavor with return through] micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.[function with cure mainly] dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, relieving cough and resolving phlegm.For jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea ， mass in the abdomen, instep plays damage, cough due to lung-heat.
Caulis Trachelospermi: be the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Winter tapped to time spring, and removing impurity, dries.[nature and flavor with return through] are bitter, are slightly cold.GUIXIN, liver, kidney channel.[function with cure mainly] dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, injury from falling down.
Rhizoma Dioscoreae Nipponicae: be the dry rhizome of Rhizoma Dioscoreae plant Dioscorea nipponica Mak. Ningpo Yam Rhizome Dioscorea nipponica Makino.Spring, Qiu Erji excavate, and clean, and removing fibrous root and crust, dry.[nature and flavor with return through] are sweet, bitter, warm.Return liver, kidney, lung meridian.[function with cure mainly] expelling wind and removing dampness, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain, relieving cough and asthma.For Bi condition, arthroncus, pain numbness, injury from falling down, lumbar sprain and QI divergeny, cough and asthma.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains described active component.
Scheme two: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
Scheme three: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
The Chinese medicine composition for the treatment of gout of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, steviosin, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: granule
Get one of scheme one to scheme three gained active component, add granule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.
Above-mentioned granule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent or whole.
The scheme being prepared as granule is preferably:
Get one of scheme one to scheme three gained active component, when being concentrated into 40-80 DEG C, relative density is the clear paste of 1.10-1.35, and dry, add binding agent, correctives, process for producing granula makes granule routinely.
The scheme being prepared as granule is more preferably:
Get whole medical material, decoct with water 2 times, each 1.5h, collect decocting liquid, filter, merging filtrate, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.30,60 DEG C of vacuum dryings, pulverizes, adds dextrin, steviosin, mixing, and dry-pressing is granulated, and subpackage, obtains granule.
Method 2: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
The scheme being prepared as syrup is more preferably:
Get whole medical material, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Method 5: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
The Chinese medicine composition for the treatment of gout of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup, oral liquid etc.
According to traditional Chinese medical science classification of diseases, gout belongs to " arthromyodynia ".It is cold, damp gas is the cause of disease, the deep viscous of its property, and damp stops and makes QI-blood circulation not smooth and occur pain numbness, therefore is called arthralgia caused mainly by damp.Sick position is at passages through which vital energy circulates, and poison is evil, and invasion ties heat-transformation mutually with cold-damp, intrinsic heat becomes expectorant, causes blood to be transported not normal, gathers and form poison in skin space between skin and muscles, suddenly red and swollen, heat, pain and do, its migratory arthralgia caused by wind joint, pain heat is very acute, if sting as tiger, touch and can not touch, due to spasm of muscles and vessels, meridians stasis blocking and having an intense pain.Although one of cause of disease of gout is damp, " the turbid stasis of blood " is one of its main cause equally, only heavy clearing away heat-damp and promoting diuresis, and ignores taking good care of spleen renal function, and Etiological " the turbid stasis of blood " can be made fundamentally not dissolve.
The present invention is with Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae, Semen Coicis invigorating the spleen for eliminating dampness, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Ramulus Mori, Rhizoma Polygoni Cuspidati, Caulis Trachelospermi, Rhizoma Dioscoreae Nipponicae promoting blood circulation to restore menstrual flow, diuretic are let out turbid, Radix Ginseng invigorating the spleen to benefit the lung, full side's collocation is scientific and reasonable, meet System of Chinese medicine, mutually collaborative, play blood circulation promoting and blood stasis dispelling altogether, diuresis acid discharge, wind-expelling pain-stopping, Xiezhuo Huayu, dampness are detoxified, the merit of strengthening the spleen kidney of draining away the mud and bring in fresh water, adjust.
A kind of Chinese medicine composition for the treatment of gout provided by the invention has the following advantages:
1, Chinese medicine composition provided by the invention effectively can treat gout caused by turbid stasis of blood damp, significantly alleviates the joint severe pain caused by gout, swelling, erythema, stiff, heating.And the present invention is compared with colchicine matched group, more effectively can reduce Level of Serum Uric Acid, obvious effective rate reaches more than 84%, and curative effect is better, and both compare has pole significant difference.
2, preparation provided by the invention is when being used for the treatment of gout disease caused by turbid stasis of blood damp, there is blood circulation promoting and blood stasis dispelling, diuresis acid discharge, wind-expelling pain-stopping effect, patient with gout serum uric acid level can be reduced, the caused pain of effective treatment turbid stasis of blood damp wind-induced red, hot, swell and ache symptom, pain when showing effect to goat has obvious curative effect.
3, Chinese medicine composition preparation method of the present invention is simple, is applicable to basic medical unit or producer's production in enormous quantities.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1: granule
Get Radix Ginseng 8g, Radix Angelicae Sinensis 25g, Semen Persicae 8g, Flos Carthami 8g, Rhizoma Smilacis Glabrae 40g, Rhizoma Dioscoreae Septemlobae 12g, Semen Coicis 18g, Ramulus Mori 10g, Rhizoma Polygoni Cuspidati 15g, Caulis Trachelospermi 18g, Rhizoma Dioscoreae Nipponicae 4g.By above-mentioned whole medical material, extracting in water 2 times, each amount of water is equivalent to 15 times, 10 times of medical material gross weight respectively, each 1.5h, collects decocting liquid, filters, merging filtrate, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.30,60 DEG C of vacuum dryings, pulverize, add dextrin, steviosin, mixing, dry-pressing is granulated, subpackage, obtains granule.
Embodiment 2: granule
Get Radix Ginseng 4g, Radix Angelicae Sinensis 15g, Semen Persicae 4g, Flos Carthami 4g, Rhizoma Smilacis Glabrae 22g, Rhizoma Dioscoreae Septemlobae 12g, Semen Coicis 12g, Ramulus Mori 10g, Rhizoma Polygoni Cuspidati 10g, Caulis Trachelospermi 10g, Rhizoma Dioscoreae Nipponicae 4g.By above-mentioned whole medical material, extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filters, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, add ethanol, make alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.
Embodiment 3: tablet
Get Radix Ginseng 8g, Radix Angelicae Sinensis 25g, Semen Persicae 8g, Flos Carthami 8g, Rhizoma Smilacis Glabrae 40g, Rhizoma Dioscoreae Septemlobae 18g, Semen Coicis 18g, Ramulus Mori 15g, Rhizoma Polygoni Cuspidati 15g, Caulis Trachelospermi 18g, Rhizoma Dioscoreae Nipponicae 8g; By above-mentioned whole medical material alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 4: capsule
Get Radix Ginseng 8g, Radix Angelicae Sinensis 15g, Semen Persicae 8g, Flos Carthami 4g, Rhizoma Smilacis Glabrae 40g, Rhizoma Dioscoreae Septemlobae 12g, Semen Coicis 12g, Ramulus Mori 10g, Rhizoma Polygoni Cuspidati 15g, Caulis Trachelospermi 18g, Rhizoma Dioscoreae Nipponicae 8g, by above-mentioned whole medical material, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.
Embodiment 5: syrup
Get Radix Ginseng 8g, Radix Angelicae Sinensis 25g, Semen Persicae 8g, Flos Carthami 8g, Rhizoma Smilacis Glabrae 40g, Rhizoma Dioscoreae Septemlobae 18g, Semen Coicis 18g, Ramulus Mori 15g, Rhizoma Polygoni Cuspidati 15g, Caulis Trachelospermi 18g, Rhizoma Dioscoreae Nipponicae 8g, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 6: powder
Get Radix Ginseng 4g, Radix Angelicae Sinensis 15g, Semen Persicae 8g, Flos Carthami 8g, Rhizoma Smilacis Glabrae 40g, Rhizoma Dioscoreae Septemlobae 18g, Semen Coicis 12g, Ramulus Mori 10g, Rhizoma Polygoni Cuspidati 15g, Caulis Trachelospermi 18g, Rhizoma Dioscoreae Nipponicae 8g, medical material cleans, and pulverizes, obtains powder of the present invention.
Clinical treatment is summed up
1 clinical data
1.1 physical data
50 examples are my Out-patient Department and inpatient, are divided into two groups at random, treatment group 25 example, male 16 example, women 9 example, 28 ~ 70 years old age, 55 years old mean age; Matched group 25 example, male 16 example, women 9 example, 22 ~ 68 years old age, 54 years old mean age.Two groups in age, sex, the course of disease, typing etc. through statistical procedures, there was no significant difference (P>0.05), has comparability.
1.2 diagnostic criteria
Diagnostic criteria meets Americanism damp disease association (American Rheumatism Association in 1977, ARA) gouty arthritis diagnostic criteria, meet Chinese Medical Association in 2004 about the diagnostic criteria about gout in " primary gout diagnosis and treatment guide " simultaneously, meet damp and hot arthromyodynia patient simultaneously.
1.3 inclusive criteria
(1) age was at the sex of 18 ~ 70 years old; (2) diagnostic criteria is met; The medicine of any treatment gout is not used in (3) 1 months; Hormone medicine is not used in (4) 6 months.All meet above condition person can include in.
1.4 exclusion standard
(1) the serious disease persons such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are merged; (2) psychotic; (3) lopsided, stiff, the disability person of advanced joint severe; (4), since this outbreak, other treatment gout and uric acid resisting medicine person had been used; (5) state of an illness is critical, be difficult to this research treatment effectiveness and safety make definite estimator.Meet above any person and namely give eliminating.
1.5 reject or the standard that comes off
(1) to the drug allergy used in this research or the person that has serious adverse reaction; (2) uncomplaisance or treatments period merge and use in other active drugs or treatment because a variety of causes has failed the course for the treatment of or the full person of data; (3) treatments period generation serious disease, can not the person of proceeding.Meet above any person can reject.
2 Therapeutic Method
2.1 treatment groups: the embodiment of the present invention 1 granule, oral, every day 3 times, each serving with the granule being equivalent to crude drug amount 100g, 2 weeks courses for the treatment of.
2.2 matched groups: colchicines tablets (every sheet 0.5mg, Xishuangbanna pharmaceutcal corporation, Ltd, the accurate word H53021369 of traditional Chinese medicines), oral, predose is 1mg, 0.5mg per hour or every 2 hours 1mg subsequently, until remission or occur the gastrointestinal side effect such as Nausea and vomiting, watery diarrhea.Maximal dose 6 ~ 8mg on the 1st.If invalid, drug withdrawal immediately.Pain relief in 48h after the oral colchicine of patient of 90%.Can continue after remission to give each 0.5mg, every day 2 ~ 3 times.2 weeks courses for the treatment of.
2.3 observation index
Level of Serum Uric Acid: before treatment and treatment after two weeks morning take a blood sample on an empty stomach with phosphotungstic acid colorimetry survey Level of Serum Uric Acid.
2.4 criterion of therapeutical effect
Work out according to " new Chinese medicine guideline of clinical investigations " that Ministry of Public Health is issued for 1993.
Clinical cure: clinical symptom disappearance, function of joint activity recovers normal, and main physico-chemical examination index is normal.
Effective: cardinal symptom disappears, and function of joint is recovered substantially, and main physico-chemical examination index is normal.
Effective: cardinal symptom disappears substantially, function of joint and main physico-chemical examination index make moderate progress.
Invalid: compared with before treatment, each side is all without improvement.
2.5 statistical method
Compare the t inspection adopting paired data mean to compare in the measurement data group of this clinical research, compare the t inspection that employing two sample average compares between group, enumeration data adopts x
2inspection, ranked data Ridit checks, and all continuous datas all adopt
represent, statistical procedures adopts SPSS 13.0 software to complete.
3 results
3.1 liang of group Clinical efficacy comparisons
Two groups of cure-remarkable-effectiveness rates are through x
2inspection, P<0.05, has significant difference, and treatment group curative effect is obviously better than matched group.In table 1.
Table 1 liang group Clinical efficacy comparison
Note: compared with matched group, * P<0.05.
Before and after 3.2 liang of group treatments, blood uric acid change is compared
Decline in various degree with more all having before treatment after the treatment of two groups of blood uric acids, treatment group compared with matched group decline more obviously, and P<0.05, has significant difference, has statistical significance.In table 2.
Before and after table 2 liang group treatment, serum uric acid level compares (μm ol/L)
Note: compared with before treating with this group, * P<0.05; Compared with matched group, #P<0.05.
4 conclusions
Gout is the disorder due to purine metabolism in body, be characterized in the uric acid metabolism imbalance occurring recurrent, and with serious local arthritis, i.e. gouty arthritis acute attack, finally in tissue, occur that urate crystal deposits, cause joint deformity, stiff, the complication such as lithangiuria, renal hypofunction.Chinese medicine composition of the present invention is used for gout caused by turbid stasis of blood damp, and pain relieving is fast, and sign disappears also fast.Clinical observation result proves: the present invention is better than matched group to red, hot, the symptom that swells and ache of gout caused by turbid stasis of blood damp and the improvement degree of activity index; Compare with matched group, the present invention can significantly reduce patient with gout serum uric acid level, and both compare has significant difference (P<0.05).Clinical observation result is pointed out: gout caused by traditional Chinese medicine composition for treating of the present invention turbid stasis of blood damp is effective, effect is fast, price is low, side effect is little, is better than prior art.
model case
1, Zhang, man, 38 years old, on June 12nd, 2012 went to a doctor, and went on business period in other places, and goat shows effect, and right crus of diaphragm ankle back heel string has an intense pain, and this is the 4th gout outbreak then.Before gout outbreak, the treatment that hospital of Dou Shi city does, Aspirin and colchicine, pain relief is also not obvious, occur on the contrary stomach discomfort some reaction, often return all experience about one week misery unbearable.Give embodiment 1 granule after making a definite diagnosis and take 7 days courses for the treatment of, that night, pain was obviously alleviated at nightfall, within second day, woke up, and ankle place pain is no longer violent, can simple motion in room.After continuing to take three courses for the treatment of, follow up a case by regular visits to more than 2 years, goat does not commit excesses again.
2, Wang, man, 38 years old, lives Xinshi District, Baoding.In December, 2013 gout outbreak is medical, and patient has Inheritance gout history.Left lower limb big toe is some redness slightly, and the acute pain in terribly hot ground, gives the embodiment of the present invention 3 tablets several hours, display curative effect, and toe pain is alleviated a little, and after taking one week, toe pain disappears substantially, is slightly numb.Continue to take two courses for the treatment of, follow up a case by regular visits to 1 year, have no recurrence.
3, Yang, female, 72 years old, Xinshi District, Baoding.Consultation time, on July 4th, 2012.Goat shows effect and goes to a doctor for second day, and panic attacks point is at fifth lumbar vertebra and periphery, and sitting and lying neither obtains, can only on all fours, and the shape of misery is abnormal, and facial torsional deformation, the sound of crying is very wretched.Give the embodiment of the present invention 2 granule immediately to take, pain relief on the same day, the second day telephone questionnaire state of an illness, can leave the bed and walk about.After taking two courses for the treatment of, follow up a case by regular visits to 1 year, have no recurrence.
4, Wang, man, 65 years old, Xinshi District, Baoding.Have the gout history of more than ten years, many places, brothers position tophus, many places, joint are out of shape.Gout panic attacks same day, give the embodiment of the present invention 4 capsule and take, misery subtracted greatly on 3, and follow up a case by regular visits to a year and a half and have a surplus, gout pain did not recur.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. treat a Chinese medicine composition for gout, it is characterized in that it is prepared from by the raw material of following weight portion: Radix Ginseng 4-8 part, Radix Angelicae Sinensis 15-25 part, Semen Persicae 4-8 part, Flos Carthami 4-8 part, Rhizoma Smilacis Glabrae 22-40 part, Rhizoma Dioscoreae Septemlobae 12-18 part, Semen Coicis 12-18 part, Ramulus Mori 10-15 part, Rhizoma Polygoni Cuspidati 10-15 part, Caulis Trachelospermi 10-18 part, Rhizoma Dioscoreae Nipponicae 4-8 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains described active component.
4. Chinese medicine composition as claimed in claim 2, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
5. Chinese medicine composition as claimed in claim 2, it is characterized in that its active component is prepared from by the following method: get whole 7 taste medical materials, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
6. treat a Chinese medicine composition for gout, treat acceptable carrier in the Chinese medicine composition of gout and pharmaceuticals industry by claim 1 and prepare and form.
7. Chinese medicine composition as claimed in claim 6, is characterized in that it is prepared from by the following method: get whole medical material, decocts with water 2 times, each 1.5h, collects decocting liquid, filters, merging filtrate, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.30,60 DEG C of vacuum dryings, pulverize, add dextrin, steviosin, mixing, dry-pressing is granulated, subpackage, obtains granule.
8. Chinese medicine composition as claimed in claim 6, it is characterized in that it is prepared from by the following method: get whole medical material, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
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| CN112043777A (en) * | 2020-09-21 | 2020-12-08 | 成都温江众氏陈中草药销售有限公司 | Medicinal liquor for treating gout |
| CN114288337A (en) * | 2022-01-14 | 2022-04-08 | 江苏农牧科技职业学院 | Traditional Chinese medicine composition for preventing and treating gosling gout and preparation method thereof |
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