CN114288337A - Traditional Chinese medicine composition for preventing and treating gosling gout and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating gosling gout and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating gosling gout and a preparation method thereof, relates to the technical field of livestock and veterinary breeding industry, and comprises giant knotweed rhizome, Chinese starjasmine stem, lotus leaf, polyporus umbellatus, talc and hydroxypropyl methyl cellulose.
Description
Technical Field
The invention relates to the technical field of livestock and veterinary breeding industry, in particular to a traditional Chinese medicine composition for preventing and treating gosling gout and a preparation method thereof.
Background
Gosling gout is also called urate deposition disease, and is a disease that the blood uric acid concentration is increased due to excessive uric acid synthesis or excretion disorder in vivo to form hyperuricemia, and then the hyperuricemia is deposited on joint capsules, joint cartilages, joint peripheries, pleuroperitoneal cavities, surfaces of various organs and other interstitial tissues in the form of urate. The disease mainly occurs to goslings within 3 weeks of age, the disease incidence is 10% -50%, the mortality rate is as high as 50%, and serious economic loss is caused to the meat goose breeding industry in China. Purine metabolic disorder and intestinal and renal uric acid excretion disorder are main reasons of gosling gout occurrence, xanthine oxidase is a key enzyme for uric acid synthesis, and inhibition of the activity of xanthine oxidase becomes a current main method for reducing uric acid, such as allopurinol, febuxostat and the like, however, excessive use of xanthine oxidase can cause bird poisoning, aggravate kidney damage and limit popularization and application of xanthine oxidase. The Yangxi and the like find that 0.1-0.3% of baking soda can be added into drinking water to alkalize urine to promote uric acid discharge and obtain better effect of preventing and treating gosling gout, but the risk of gout and urolithiasis of poultry is increased when the addition amount of Stachys sieboldii in the diet exceeds 1%. However, the disease is related to various factors such as nutrition, pathogeny and the like, the pathogenesis is complex, and the latest research finds that the inflammatory injury of kidney tissues can cause the growth of the young gout geese to be slow after the young gout geese are healed, even die, and great difficulty is brought to clinical prevention and control. In conclusion, the search for a multi-path and multi-target comprehensive prevention and treatment measure with safe and stable new components and low toxic and side effects is imperative.
Giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and grifola have thousands of years of historical experiences in the aspect of preventing and treating gout, the traditional recorded traditional Chinese medicine classical prescription and self-prepared prescription of medical personnel for treating gout have more than one hundred, the curative effect is reliable, the toxic and side effects are small, the better curative effect is obtained in clinical treatment, and the potential prevention and treatment effect on gosling gout can be achieved.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for preventing and treating gosling gout and a preparation method thereof, and solves the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine composition for preventing and treating gosling gout comprises, by weight, 10-30 parts of giant knotweed rhizome, 5-15 parts of Chinese starjasmine stem, 5-15 parts of lotus leaf, 5-10 parts of polyporus umbellatus, 5-10 parts of talc and 20-30 parts of hydroxypropyl methyl cellulose.
Preferably, the traditional Chinese medicine composition for preventing and treating gosling gout comprises, by weight, 10-20 parts of giant knotweed, 10-15 parts of Chinese starjasmine stem, 5-10 parts of lotus leaf, 5-10 parts of polyporus umbellatus, 5-10 parts of talc and 25-30 parts of hydroxypropyl methyl cellulose.
Further preferably, the optimal effect formula of the traditional Chinese medicine composition comprises 20 parts by weight of giant knotweed, 12 parts by weight of Chinese starjasmine stem, 8 parts by weight of lotus leaf, 5 parts by weight of polyporus umbellatus, 6 parts by weight of talc and 30 parts by weight of hydroxypropyl methyl cellulose.
A preparation method of a traditional Chinese medicine composition for preventing and treating gosling gout comprises the following steps:
s1, sequentially weighing giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and umbellate pore fungus according to the selected mass ratio;
s2, sequentially crushing the giant knotweed rhizome, the Chinese starjasmine stem, the lotus leaf and the polyporus umbellatus which are weighed in the step S1 to a fineness of 40-60 meshes;
s3, adding the smashed giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and grifola in the step S2 into ultrapure water according to the mass ratio of 1:15, and sealing and extracting for 4 hours in a water bath kettle at the constant temperature of 85 ℃. Filtering to obtain supernatant and residue, drying the supernatant, concentrating to obtain extract, further drying, and pulverizing into extract powder;
s4, adding the medicine residues obtained in the step S3 into a 60-85% ethanol solution according to the mass ratio of 1:10, performing reflux extraction at 75 ℃ for 3 hours, collecting filtrate, concentrating at 45 ℃ to obtain an extract, further drying, and crushing into extract powder;
s5, selecting mass hydroxypropyl methyl cellulose and talcum powder of the extract powder obtained in the steps S3 and S4, fully and uniformly mixing, spraying 3-5% PVP K30 absolute ethyl alcohol while stirring, granulating, and drying to obtain the traditional Chinese medicine composition.
Compared with the prior art, the invention has the following beneficial effects:
1. the traditional Chinese medicine composition for preventing and treating gosling gout is characterized in that by applying a network pharmacology theory and analyzing the interaction characteristics of giant knotweed rhizome, Chinese starjasmine stem, lotus leaf, polyporus umbellatus and active ingredients thereof and gout gene targets, gout is prevented and treated systematically on the whole, the fatality rate of gout is effectively reduced, and the production benefit is improved.
2. The selected giant knotweed rhizome, Chinese starjasmine stem and lotus leaf are all xanthine oxidase inhibitors, can well reduce the generation of uric acid, and simultaneously has good anti-inflammatory effect, relieves inflammatory injury of the kidney and other tissues of the gosling, maintains the renal function and promotes the discharge of uric acid.
3. The selected Polyporus umbellatus and pulvis Talci have diuretic effect, and can promote uric acid to be discharged from urine, reduce uric acid accumulation in vivo, adsorb partial uric acid in intestinal tract, promote uric acid in blood to be excreted via intestine, and relieve renal pressure.
4. The selected hydroxypropyl methyl cellulose has the characteristics of hydrophilic gel, has a slow release effect on giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and polyporus umbellatus, can reduce the dosage and the administration times of the traditional Chinese medicine, can effectively avoid the obvious fluctuation of the blood concentration, and can reduce the toxic and side effects caused by frequent use, so that the traditional Chinese medicine can exert better curative effect.
5. The selected giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and umbellate pore fungus are low in cost, easy to manufacture and store and convenient to popularize and use.
Drawings
FIG. 1 shows that the invention prevents the occurrence of gosling gout;
FIG. 2 shows the cure rate of the present invention for gosling gout;
FIG. 3 shows the clinical effect of the present invention on gout in gosling;
FIG. 4 is a flow chart of the preparation method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides the following technical scheme: a traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 10-30 parts of giant knotweed, 5-15 parts of Chinese starjasmine stem, 5-15 parts of lotus leaf, 5-10 parts of polyporus umbellatus, 5-10 parts of talc and 20-30 parts of hydroxypropyl methyl cellulose according to parts by weight of raw materials.
Preferably, the traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 10-20 parts of giant knotweed, 10-15 parts of Chinese starjasmine stem, 5-10 parts of lotus leaf, 5-10 parts of polyporus umbellatus, 5-10 parts of talc and 25-30 parts of hydroxypropyl methyl cellulose according to the weight parts of the raw materials.
Further preferably, the optimal effect formula of the traditional Chinese medicine composition comprises 20 parts by weight of giant knotweed, 12 parts by weight of Chinese starjasmine stem, 8 parts by weight of lotus leaf, 5 parts by weight of polyporus umbellatus, 6 parts by weight of talc and 30 parts by weight of hydroxypropyl methyl cellulose.
A preparation method of a traditional Chinese medicine composition for preventing and treating gosling gout comprises the following steps:
s1, sequentially weighing giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and umbellate pore fungus according to the selected mass ratio;
s2, sequentially crushing the giant knotweed rhizome, the Chinese starjasmine stem, the lotus leaf and the polyporus umbellatus which are weighed in the step S1 to a fineness of 40-60 meshes;
s3, adding the smashed giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and grifola in the step S2 into ultrapure water according to the mass ratio of 1:15, and sealing and extracting for 4 hours in a water bath kettle at the constant temperature of 85 ℃. Filtering to obtain supernatant and residue, drying the supernatant, concentrating to obtain extract, further drying, and pulverizing into extract powder;
s4, adding the medicine residues obtained in the step S3 into a 60-85% ethanol solution according to the mass ratio of 1:10, performing reflux extraction at 75 ℃ for 3 hours, collecting filtrate, concentrating at 45 ℃ to obtain an extract, further drying, and crushing into extract powder;
s5, selecting mass of hydroxypropyl methyl cellulose and talcum powder, fully and uniformly mixing the extract powder obtained in the steps S3 and S4, spraying 3-5% PVP K30 absolute ethyl alcohol while stirring, granulating, and drying to obtain the traditional Chinese medicine composition.
Example 1
Firstly, weighing 20 parts of giant knotweed rhizome, 12 parts of Chinese starjasmine stem, 8 parts of lotus leaf, 5 parts of polyporus umbellatus, 6 parts of talcum and 30 parts of hydroxypropyl methyl cellulose in sequence according to the parts by weight of raw materials;
then, sequentially crushing the weighed giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and grifola till the fineness of 40 meshes; then adding the smashed giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and grifola into ultrapure water according to the mass ratio of 1:15, and carrying out closed extraction for 4 hours in a water bath kettle at the constant temperature of 85 ℃. Filtering to obtain supernatant and residue, drying the supernatant, concentrating to obtain extract, further drying, and pulverizing into extract powder;
adding the medicine residues into an 85% ethanol solution according to the mass ratio of 1:10, performing reflux extraction at 75 ℃ for 3 hours, collecting filtrate, concentrating at 45 ℃ to obtain an extract, further drying, and crushing into extract powder.
And (3) fully and uniformly mixing the extract powder obtained by refining the clear liquid and the dregs, hydroxypropyl methyl cellulose and talcum powder with selected mass, spraying 5% PVP K30 absolute ethyl alcohol while stirring, granulating, and drying to obtain the traditional Chinese medicine composition.
Example 2
The invention provides a technical scheme that: a traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 15 parts of giant knotweed rhizome, 12 parts of Chinese starjasmine stem, 10 parts of lotus leaf, 8 parts of polyporus umbellatus, 6 parts of talcum and 20 parts of hydroxypropyl methyl cellulose according to the parts by weight of raw materials.
The specific preparation procedure was the same as in example 1.
Example 3
The invention provides a technical scheme that: a traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 15 parts of giant knotweed rhizome, 15 parts of Chinese starjasmine stem, 8 parts of lotus leaf, 5 parts of polyporus umbellatus, 10 parts of talcum and 25 parts of hydroxypropyl methyl cellulose according to the parts by weight of raw materials.
The specific preparation procedure was the same as in example 1.
Example 4
The invention provides a technical scheme that: a traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 10 parts of giant knotweed rhizome, 10 parts of Chinese starjasmine stem, 5 parts of lotus leaf, 5 parts of polyporus umbellatus, 5 parts of talcum and 30 parts of hydroxypropyl methyl cellulose according to the parts by weight of raw materials.
The specific preparation procedure was the same as in example 1.
Example 5
The invention provides a technical scheme that: a traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 20 parts of giant knotweed rhizome, 15 parts of Chinese starjasmine stem, 10 parts of lotus leaf, 10 parts of polyporus umbellatus, 10 parts of talcum and 22 parts of hydroxypropyl methyl cellulose according to the parts by weight of raw materials.
The specific preparation procedure was the same as in example 1.
Example 6
A traditional Chinese medicine composition for preventing and treating gosling gout is prepared by weighing 20 parts of giant knotweed rhizome, 15 parts of Chinese starjasmine stem, 5 parts of lotus leaf, 5 parts of polyporus umbellatus, 5 parts of talcum and 28 parts of hydroxypropyl methyl cellulose according to the parts by weight of raw materials.
The specific preparation procedure was the same as in example 1.
Further, the optimal effect formula of the composition in example 1 is 20 parts of giant knotweed rhizome, 10 parts of Chinese starjasmine stem, 8 parts of lotus leaf, 5 parts of polyporus umbellatus, 6 parts of talcum and 30 parts of hydroxypropyl methyl cellulose, and the composition improves the gosling gout and improves the production performance through multiple ways of inhibiting uric acid generation, promoting uric acid excretion, protecting the kidney function, inhibiting inflammatory reaction and the like, is economical and efficient, and embodies the overall treatment characteristics of the traditional Chinese medicine.
Animal experiments prove that the traditional Chinese medicine composition for preventing and treating gosling gout designed and prepared in the embodiment has better effect compared with the embodiment 1, and the clinical test effect is as follows:
the first test and the second test both use the theory that the gosling gout is easily caused by high-protein feed as the basis, and use feed with 24% of crude protein to successfully create a gosling gout model.
Test-prevention test
400 1-day-old geese were equally divided into 8 groups, and the 1 st group was fed with 16% crude protein feed, the 2 nd group was fed with 24% crude protein feed, and the 3 rd to 8 th groups were fed with 24% crude protein feed containing 1% of the Chinese medicinal composition of examples 1 to 6, respectively. The test adopts double-layer cage culture, free food intake and drinking water intake, and immunization according to a normal immunization program, wherein the test period is 15 days. The clinical manifestations of each experimental animal are observed and recorded every day during the test period, when goslings have early clinical symptoms such as slow movement, necking, white feces, and the like, the goslings show that the pericardium is thickened after autopsy, white crystals are attached or coated, the kidneys are pale and swollen, the speckled kidneys and the ureters are thickened, white thin feces are accumulated in the end of the rectum, the mark is suspected to be the disease, and the disease incidence of each group is calculated after the test is finished. After the test is finished, 10 random groups are selected for measuring the weight and the content of uric acid in blood. The results are shown in Table 1 and FIG. 1. It can be seen that the body weights of groups 3 to 8 were significantly higher than those of group 2, the uric acid content in blood was significantly lower than that of group 2, the gout incidence was significantly lower than that of group 2, and the effect of group 3 was the best. The traditional Chinese medicine composition can effectively prevent the occurrence of gosling gout.
TABLE 1 changes in body weight and blood uric acid
Note: p < 0.05 compared to group 2.
Test two treatment test
300 1-day-old geese are selected and fed with basic feed with crude protein content of 24%, and 90 goslings with clinical symptoms of slow growth, slow movement, necking, swollen joints, white feces and the like are selected when 15 days are old. It was divided equally into 3 groups: a basal feed group (feed containing 16% of crude protein), an allopurinol control group (feed containing 16% of crude protein added at the dose of 60mg/kg of allopurinol), and a Chinese medicinal composition group (feed containing 18% of crude protein added according to 1% of the Chinese medicinal composition in example 1). Run period 7 d. After the test is finished, the relative weight gain rate (the relative weight gain rate is the weight gain mass of the test group/the weight gain mass of the basic feed group) multiplied by 100 percent and the cure rate is (the number of cured results/the total number of results) multiplied by 100 percent are calculated, and 10 selected in each group are used for measuring the content of uric acid, creatinine, tumor necrosis factor alpha and interleukin 6 in the blood. The results are shown in Table 2 and FIG. 2. It can be seen that the relative weight gain rate of the Chinese medicinal composition group is higher than that of the allopurinol control group and the basal feed group, and the contents of uric acid, creatinine, tumor necrosis factor alpha and interleukin 6 in blood are lower than that of the allopurinol control group and the basal feed group; the cure rate of the traditional Chinese medicine composition group is also obviously higher than that of the other two groups. The traditional Chinese medicine composition can achieve the effect of treating gout and improve the production performance of goslings by reducing the uric acid level of gout goslings, protecting kidney functions, inhibiting inflammatory reactions and the like.
TABLE 2 relative weight gain and blood Biochemical index changes
Note: p < 0.05 compared to basal feed group; # denotes P < 0.05 compared to the allopurinol control group.
Test three clinical application tests
3000 goslings are shared in a goose farm, and partial gout is determined according to clinical symptoms and autopsy characteristics. Randomly selecting 400 gouty goslings and equally dividing into 2 groups: group 1 was a herbal composition group fed with a basal diet (16% crude protein) containing 1% of the herbal composition of example 1, and group 2 was a basal diet group fed with a basal diet (16% crude protein). The clinical manifestations of the sick gosling are observed and recorded every day, when the appetite, the movement, the excrement and the like are recovered to be normal, the joint swelling subsides, and the growth condition is good, the cure is shown, and the cure rate (the cure rate is the cure number/the total number) is multiplied by 100%. As shown in fig. 3, it can be seen that the cure rate of the traditional Chinese medicine composition group is significantly increased with the passage of time, reaching 90% at day 10, which is significantly higher than that of the basal feed group. The traditional Chinese medicine composition has obvious treatment effect.
In conclusion, the traditional Chinese medicine composition for preventing and treating gosling gout is medicine-food homologous, wide in raw material source, low in price and convenient to operate, enriches the treatment method of gosling gout, can effectively reduce the incidence rate of gosling gout, reduce the levels of uric acid and inflammatory factors in gout gosling blood, protect kidney functions, improve the cure rate and is worthy of market popularization and application.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. A traditional Chinese medicine composition for preventing and treating gosling gout is characterized in that: the traditional Chinese medicine composition comprises, by weight, 10-30 parts of giant knotweed rhizome, 5-15 parts of Chinese starjasmine stem, 5-15 parts of lotus leaf, 5-10 parts of grifola, 5-10 parts of talc and 20-30 parts of hydroxypropyl methyl cellulose.
2. The traditional Chinese medicine composition for preventing and treating gosling gout according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises, by weight, 10-20 parts of giant knotweed rhizome, 10-15 parts of Chinese starjasmine stem, 5-10 parts of lotus leaf, 5-10 parts of grifola, 5-10 parts of talc and 25-30 parts of hydroxypropyl methyl cellulose.
3. The traditional Chinese medicine composition for preventing and treating gosling gout as claimed in claims 1 to 2, wherein: comprises 20 parts of giant knotweed rhizome, 12 parts of Chinese starjasmine stem, 8 parts of lotus leaf, 5 parts of polyporus umbellatus, 6 parts of talcum and 30 parts of hydroxypropyl methyl cellulose according to the parts by weight of the raw materials.
4. A preparation method of a traditional Chinese medicine composition for preventing and treating gosling gout is characterized by comprising the following steps:
s1, sequentially weighing giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and umbellate pore fungus according to the selected mass ratio;
s2, sequentially crushing the giant knotweed rhizome, the Chinese starjasmine stem, the lotus leaf and the polyporus umbellatus which are weighed in the step S1 to a fineness of 40-60 meshes;
s3, adding the smashed giant knotweed rhizome, Chinese starjasmine stem, lotus leaf and grifola in the step S2 into ultrapure water according to the mass ratio of 1:15, and sealing and extracting for 4 hours in a water bath kettle at the constant temperature of 85 ℃. Filtering to obtain supernatant and residue, drying the supernatant, concentrating to obtain extract, further drying, and pulverizing into extract powder;
s4, adding the medicine residues obtained in the step S3 into a 60-85% ethanol solution according to the mass ratio of 1:10, performing reflux extraction at 75 ℃ for 3 hours, collecting filtrate, concentrating at 45 ℃ to obtain an extract, further drying, and crushing into extract powder;
s5, selecting mass of hydroxypropyl methyl cellulose and talcum powder, fully and uniformly mixing the extract powder obtained in the steps S3 and S4, spraying 3-5% PVP K30 absolute ethyl alcohol while stirring, granulating, and drying to obtain the traditional Chinese medicine composition.
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| CN104984180A (en) * | 2015-07-07 | 2015-10-21 | 孙仲亮 | Traditional Chinese medicine combination for treating gout and preparing method thereof |
| CN106543249A (en) * | 2016-11-14 | 2017-03-29 | 广州和匠科技有限公司 | It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati |
| CN110051706A (en) * | 2019-05-15 | 2019-07-26 | 广东省微生物研究所（广东省微生物分析检测中心） | The preparation method of extract of Zhuling and its application in terms of preparing treatment/prevention high lithemia related disease medicine/health product |
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| CN104984180A (en) * | 2015-07-07 | 2015-10-21 | 孙仲亮 | Traditional Chinese medicine combination for treating gout and preparing method thereof |
| CN106543249A (en) * | 2016-11-14 | 2017-03-29 | 广州和匠科技有限公司 | It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati |
| CN110051706A (en) * | 2019-05-15 | 2019-07-26 | 广东省微生物研究所（广东省微生物分析检测中心） | The preparation method of extract of Zhuling and its application in terms of preparing treatment/prevention high lithemia related disease medicine/health product |
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