CN106543249A - It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati - Google Patents
It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati Download PDFInfo
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- CN106543249A CN106543249A CN201610996992.7A CN201610996992A CN106543249A CN 106543249 A CN106543249 A CN 106543249A CN 201610996992 A CN201610996992 A CN 201610996992A CN 106543249 A CN106543249 A CN 106543249A
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C07H1/08—Separation; Purification from natural products
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Abstract
The present invention relates to a kind of extract the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout from Rhizoma Polygoni Cuspidati, after Rhizoma Polygoni Cuspidati raw material is smashed, alcohol heating reflux is added slightly to be extracted, then the pH of crude extract is adjusted to carrying out thick purification, purified using polyamide resin column again, and differentiate eluent with thin layer chromatography, collect the eluent with high accounting target compound and merge, gained eluent is prepared into into product finally.The present invention is decocted using 70% ethanol, and polyamide is extracted, and autotelic enrichment subject monomers, low cost, high income easily realize industrialization and scale.Capsule prepared by this method, tablet, mixture etc., taking convenience, meet multiple demand.
Description
Technical field
The present invention relates to a kind of preparation method of medicinal monomer, and in particular to one kind extracts preventing and treating antihyperuricemic from Rhizoma Polygoni Cuspidati
Disease and the preparation method of the medicinal monomer of gout.
Background technology
Prevention to hyperuricemia and gout at present mainly limits high purine food, and control is drunk, in treatment both
The arthritis controlled by acute attack, long-term treatment hyperuricemia, prevents tophaceous deposition again.
Chemotherapys are divided into treatment gouty arthritises and correct two class of hyperuricemia.The former have Colchicine,
Nonsteroidal antiinflammatory drug, glucocorticoid, they can soon and effectively alleviating pain, reduce inflammation;The latter has probenecid, benzene bromine
Ma Long (promoting the excretion of uric acid) and allopurinol (suppressing the generation of uric acid).But the untoward reaction of these medicines is more, benzene bromine
Ma Longke causes serious hepatic injury and nervous system untoward reaction.(opening and reach. narcaricin causes nervous system serious bad anti-
Answer l examples. Journal of Chinese Hospital Pharmacy, 2000,20:639.) allopurinol is the xanthine oxidase for uniquely clinically using
Inhibitor, can pass through the generation for suppressing xanthine oxidase to suppress uric acid, but its presence can cause skin allergy, hepatic injury, prestige
The toxic and side effects such as the super quick allergy syndrome of side of body life., due to single varieties, and there is untoward reaction in uric acid resisting Western medicine,
Limit clinical practice.(Guo Liping, Wang Rui. the epidemic of hyperuricemia disease and medicinal application [J]. Chinese medicine should
With with monitoring, 2006,3 (4):24-27.)
The report of Chinese medicine hyperuricemia and primary gout is more.In clinical practice and daily life, people
Find that some can treat the effective single medicinal material of hyperuricemia, wherein the active component and pharmacology of many medicines are made
With being elucidated with.As Rhizoma Dioscoreae Septemlobae, Cortex Fraxini, Bai Ai, Carlina acauliss, Radix Clematidis, Semen Plantaginiss, Cortex Phellodendri, Herba Lysimachiae, Radix Gentianae Macrophyllae etc. have certain
Uric acid resisting is acted on.(woods ultramarine, Xie Jian, Wang Haidong. white Chinese mugwort experimentation [J] of the extracting solution to hyperuricemia rat. Chinese wind
Damp disease magazine, 2005,9 (8):509-510. woodss phoenix is put down, and appoints enlightenment, Song Enfeng etc. and Radix Clematidis is to urate nephropathy rat
Experimentation [J]. Chinese patent medicine, 2006,28 (6):842-845.)
Research shows that Herba Epimedii, Semen Coiciss, Rhizoma Alismatis, Semen Plantaginiss, Radix Gentianae Macrophyllae can increase urate excretion, and Radix Gentianae Macrophyllae can also increase urine
The dissolving of acid;Herba Lycopi, Radix Angelicae Sinensis can suppress uric acid to synthesize.Separately have research show, Cortex Fraxini, Herba Plantaginiss, Radix Et Rhizoma Rhei, Rhizoma Atractylodis can uricosuric from
Kidney is excluded, and Radix Et Rhizoma Rhei energy uricosuric is excreted from stool;Bulbus Lilii, Pseudobulbus Cremastrae Seu Pleioness etc. are acted on colchicinoid sample, can be suppressed white
Cell chemotaxis, so as to mitigate the inflammatory reaction of gouty arthritises;Exocarpium Benincasae, Pericarpium Arecae, Cortex Mori, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Poria
The promoting the circulation of QI to induce diuresis such as skin medicine can improve endogenous creatinine clearance rate, increase urine volume, discharge uric acid, reduce blood uric acid.(Lee's table, Sun Lin. it is existing
For Kidney Disease [M]. Nanchang:In Jiangxi Science technology publishing house, 2000.537-543. Shen Qing methods. tcm clinical practice nephropathy
Learn [M]. Shanghai:Shanghai scientific and technical literature publishing house, 1998:206-211.)
Dry rhizome and root of the Rhizoma Polygoni Cuspidati for Liao Ke plant polygonum cuspidatums (Polygonum cuspidatum Sieb.et Zucc.).
Main product is in being distributed in Shandong, Henan, Shaanxi, Hubei, Hunan, Jiangxi, Fujian, Taiwan, Yunnan, Sichuan, Guizhou, Guangdong, Anhui
In province.Spring, the excavation of two season of autumn remove fibrous root, cleaning, drying;Or fresh-cut is taken advantage of into disconnected or sheet, dry.Rhizoma Polygoni Cuspidati mainly contains anthraquinone
Class, flavone and flavonoid glycoside, fragrant acids, Phenylpropanoid Glycosides class, stilbene glycoside, sterols, organic acid, saponinss and volatile oil
The chemical compositions such as class.Rhizoma Polygoni Cuspidati has antitumor, antibacterial, anti-inflammatory and antalgic, improves the aspects such as microcirculation, uric acid resisting, renal function protecting.
Jing pharmacological testings confirm that Rhizoma Polygoni Cuspidati extract has the activity for suppressing XOD, can suppress purinase, make hypoxanthine and xanthine not
Uric acid can be converted into, thus serum Uric Acid Concentration can be reduced rapidly, be suppressed tophuses and renal calculuss to be formed, and promote tophuses to disappear
Remove.Thus, Rhizoma Polygoni Cuspidati can also reach the wind-induced arthralgia of alleviation pain.Rhizoma Polygoni Cuspidati mainly has removing dampness through diuresis and removing jaundice, heat-clearing and toxic substances removing, dissipating blood stasis to stop
Pain relieving cough and resolving phlegm.Clinically it is usually used in jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea , Disorder
Abdominal mass is gathered, traumatic injury, the treatment of cough due to lung-heat.
Treatment by Chinese herbs hyperuricemia and gout it is evident in efficacy, but Chinese medicine Shortcomings show several in use
Individual aspect:1st, conventional preparation and instructions of taking are inconvenient, such as decocting method, taste weight when taking, taking, and because during personal decoction
Between it is different with decocting method, curative effect can not be completely secured;2nd, taking dose is big, decocts or directly crush the dosage form for preparing, composition
Composition includes active component and invalid component, and taking dose is big, it is impossible to reach the effect that Special Nursing in Special Disease is controlled, and is possible to produce poison
Side effect;3rd, monomeric compound low yield, high cost are obtained with modern separating and purifying technology, is difficult to realize scale and industry
Change;4th, realize that monomeric compound group still has certain technical difficulty, and high cost by modern synthetic technology.
The content of the invention
For the above-mentioned Chinese medicine problem that Shortcomings are showed in use, a kind of consumption of present invention offer is little, use
Convenience, few untoward reaction, low cost, effect substantially, be easy to the industrialized system for preventing and treating hyperuricemia and the medicinal monomer of gout
Preparation Method.
The purpose of the present invention will be achieved through the following technical solutions:One kind is extracted from Rhizoma Polygoni Cuspidati and prevents and treats hyperuricemia and pain
The preparation method of expelling wind drug monomer, comprises the following steps:
Step one, it is thick to extract:After Rhizoma Polygoni Cuspidati raw material is smashed, the raw material of certain mass is weighed, add 20 times of 70% ethanol of amount
After being heated to reflux 2h, medicinal residues are extracted, 15 times of 70% alcohol heating reflux 1.5h of amount in medicinal residues, will be added, united extraction liquid is cold
1d is hidden, high speed centrifugation discards insoluble matter, and vacuum distillation ethanol obtains crude extract to relative density 1.2;
Step 2, thick purification:, to 9, cold preservation 1d, high speed centrifugation are dense for crude extract pH value in sodium hydroxide regulating step one
Contracting liquid, discards insoluble matter, and hydrochloric acid adjusts pH to neutrality, and cold preservation 1d, high speed centrifugation discard insoluble matter, obtain extracting solution;
Step 3, chromatographic column purification:By polyamide resin column on the extracting solution in step 2, static adsorption 2 hours, use
20BV water elutions, discard water elution part, then with different concentration ethanol eluting successively from low to high, are differentiated with thin layer chromatography
Whether containing a certain monomer and its relative amount in monomeric compound group in eluent, collect with high accounting target compound
Eluent simultaneously merges, and gained eluent is prepared into product.
Preferably, described a kind of extraction from Rhizoma Polygoni Cuspidati prevents and treats the preparation method of hyperuricemia and the medicinal monomer of gout,
The Rhizoma Polygoni Cuspidati raw material includes Quercitrin-3-O-glucoside, Quercetin -3-O- galactoside, Quercetin -3- galactosides.
Preferably, described a kind of extraction from Rhizoma Polygoni Cuspidati prevents and treats the preparation method of hyperuricemia and the medicinal monomer of gout,
In the step one, the product of eluent processing includes capsule, tablet and mixture.
Preferably, described a kind of extraction from Rhizoma Polygoni Cuspidati prevents and treats the preparation method of hyperuricemia and the medicinal monomer of gout,
In the step 3, the preparation method of capsule is:It is concentrated in vacuo, it is vacuum dried or is spray-dried and to obtain fine powder, plus 6 times of amounts 20%
Gelatinized corn starch, pelletizes encapsulated.
Preferably, described a kind of extraction from Rhizoma Polygoni Cuspidati prevents and treats the preparation method of hyperuricemia and the medicinal monomer of gout,
The preparation method of the tablet is:The vacuum drying of gained eluent is spray-dried to obtain fine powder, add 6 times of 20% gelatinized corn starches of amount, 1
Amount 10%PVP (polyvidone) ethanol, granulation, dry, tabletting again.
Preferably, described a kind of extraction from Rhizoma Polygoni Cuspidati prevents and treats the preparation method of hyperuricemia and the medicinal monomer of gout,
The preparation method of the mixture is:Gained eluent concentrates or is diluted to the extractum of relative density 1.2, and bottling makes oral liquid.
The invention has the beneficial effects as follows:Medicinal monomer of the present invention be flavone compound, by Quercetin with pass through 3
Position oxygen atom connects the monoglycosides composition that a monosaccharide is formed, the such as dissolubility such as n-butyl alcohol, ethyl acetate in medium polar solvent
Preferably, and with certain water solublity.The present invention is decocted using 70% ethanol, and polyamide is extracted, autotelic enrichment mesh
Mark monomeric compound group, low cost, high income easily realize industrialization and scale.The capsule of inventive method preparation, piece
Agent, mixture etc., taking convenience, meet multiple demand.
Specific embodiment
To more fully understand the present invention, the present invention is made further specifically to illustrate below by following examples, but not
Limitation of the invention is can be regarded as, it is nonessential according to some that foregoing invention content is made for those skilled in the art
Improve and adjustment, be also considered as being within the scope of the present invention.
Embodiment 1:The preparation method of capsule in the present invention
It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati, comprise the following steps:
Step one, it is thick to extract:After Rhizoma Polygoni Cuspidati raw material is smashed, the raw material of certain mass is weighed, add 20 times of 70% ethanol of amount
After being heated to reflux 2h, medicinal residues are extracted, 15 times of 70% alcohol heating reflux 1.5h of amount in medicinal residues, will be added, united extraction liquid is cold
1d is hidden, high speed centrifugation discards insoluble matter, and vacuum distillation ethanol obtains crude extract to relative density 1.2;
Step 2, thick purification:, to 9, cold preservation 1d, high speed centrifugation are dense for crude extract pH value in sodium hydroxide regulating step one
Contracting liquid, discards insoluble matter, and hydrochloric acid adjusts pH to neutrality, and cold preservation 1d, high speed centrifugation discard insoluble matter, obtain extracting solution;
Step 3, chromatographic column purification:By polyamide resin column on the extracting solution in step 2, static adsorption 2 hours, use
20BV water elutions, discard water elution part, then with different concentration ethanol eluting successively from low to high, are differentiated with thin layer chromatography
Whether containing a certain monomer and its relative amount in monomeric compound group in eluent, collect with high accounting target compound
Eluent simultaneously merges, and is vacuum dried or is spray-dried and to obtain fine powder, adds 20% gelatinized corn starch of 6 times of amounts, granulation, drying to load 3#
Hungry area softgel shell, the content-filled about 0.32g of every hungry area softgel shell are clean, select grain, make the finished product of appropriate packing specification.
Embodiment 2:The preparation method of tablet in the present invention
It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati, comprise the following steps:
Step one, it is thick to extract:After Rhizoma Polygoni Cuspidati raw material is smashed, the raw material of certain mass is weighed, add 20 times of 70% ethanol of amount
After being heated to reflux 2h, medicinal residues are extracted, 15 times of 70% alcohol heating reflux 1.5h of amount in medicinal residues, will be added, united extraction liquid is cold
1d is hidden, high speed centrifugation discards insoluble matter, and vacuum distillation ethanol obtains crude extract to relative density 1.2;
Step 2, thick purification:, to 9, cold preservation 1d, high speed centrifugation are dense for crude extract pH value in sodium hydroxide regulating step one
Contracting liquid, discards insoluble matter, and hydrochloric acid adjusts pH to neutrality, and cold preservation 1d, high speed centrifugation discard insoluble matter, obtain extracting solution;
Step 3, chromatographic column purification:By polyamide resin column on the extracting solution in step 2, static adsorption 2 hours, use
20BV water elutions, discard water elution part, then with different concentration ethanol eluting successively from low to high, are differentiated with thin layer chromatography
Whether containing a certain monomer and its relative amount in monomeric compound group in eluent, collect with high accounting target compound
Eluent simultaneously merges, and is vacuum dried or is spray-dried and to obtain fine powder, adds 5 times of 20% gelatinized corn starches of amount, 1 times of amount 10%PVP (poly- dimension
Ketone) ethanol, granulation, drying, it is tabletted it is heavy be for about 0.4g former piece, sugar coating, chip select, make appropriate packing specification into
Product.
Embodiment 3:The preparation method of mixture in the present invention
It is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati, comprise the following steps:
Step one, it is thick to extract:After Rhizoma Polygoni Cuspidati raw material is smashed, the raw material of certain mass is weighed, add 20 times of 70% ethanol of amount
After being heated to reflux 2h, medicinal residues are extracted, 15 times of 70% alcohol heating reflux 1.5h of amount in medicinal residues, will be added, united extraction liquid is cold
1d is hidden, high speed centrifugation discards insoluble matter, and vacuum distillation ethanol obtains crude extract to relative density 1.2;
Step 2, thick purification:, to 9, cold preservation 1d, high speed centrifugation are dense for crude extract pH value in sodium hydroxide regulating step one
Contracting liquid, discards insoluble matter, and hydrochloric acid adjusts pH to neutrality, and cold preservation 1d, high speed centrifugation discard insoluble matter, obtain extracting solution;
Step 3, chromatographic column purification:By polyamide resin column on the extracting solution in step 2, static adsorption 2 hours, use
20BV water elutions, discard water elution part, then with different concentration ethanol eluting successively from low to high, are differentiated with thin layer chromatography
Whether containing a certain monomer and its relative amount in monomeric compound group in eluent, collect with high accounting target compound
Eluent simultaneously merges, and is concentrated into relative density 1.2, adds sweeting agent, preservative, clarifier etc., places, and filtration takes filtrate, goes out
Bacterium, fill are rolled lid, make the finished product of appropriate packing specification into the oral liquid of 10ml/.
Embodiment 4
1 basic document:All cases derive from outpatient service, and totally 60, men and women is each 30.It is divided into treatment using table of random number
Group 30, matched group 30, two groups of sexes, age, course of disease comparing differences are not statistically significant.
2 diagnostic criterias
2.1 Western medicine diagnostic criteria
1. write within 2005 according to Chinese Medical Association《Clinic diagnosis guide rheumatism fascicle》Standard:Male's blood
Uric acid level>417mmol/L;Women Level of Serum Uric Acid>357mmol/L;2. acute gouty arthritises Western medicine diagnostic criteria (reference
American Rheumatism Association's standard in 1977) (1), look in synovial bursa liquid and see specificity uric acid crystal;(2), tophuses Jing chemical method
Or PLM, it was demonstrated that crystallize containing Monosodium urate;Possess following clinical manifestation, lab testing and x line signs etc.
6 persons in 12:1), more than 1 time acute arthritises outbreak:Inflammation shows in 1 day and peaks;2), monarthritis are sent out
Make;3), affected skin is in kermesinus;4), Metatarsophalangeal joint pain or swelling;5) Metatarsophalangeal joint is involved in, unilateral outbreak;
6) midtarsal joints are involved in, unilateral outbreak;7), there can be tophuses;8), hyperuricemia;9), x-ray shows joint asymmetry
Swelling;10), x ray photograph shows that cyst is not with bone erosion under cortical bone;11) during, arthritis are shown effect, joint fluid is not with microorganism
Culture is negative.Clarify a diagnosis by possessing any l items in above-mentioned 2.
2.2 TCM syndrome diagnostic criteria:Clinical manifestation is retention of damp-heat in the interior syndrome person:Joint is red, swollen, hot, pain, and song is stretched not
Profit;Occur together heat, heaviness of the head as if it were tightly bandaged, heavy limb fiber crops, fatigue and weakness, mouth glutinous or bitter taste, loose stool is not well or stool is smooth, it is red to urinate;Body of the tongue
Red or light red, side print with teeth, yellowish fur, soft pulse or rolling pulse or sliding number.
3 Therapeutic Method:Treatment group gives oral capsule of the present invention, every 0.3g, 1 every time, once a day;Matched group
Give allopurinol tablet 0.1g/ time, 2 times/d.Two groups of courses for the treatment of are 4 weeks, follow-up 2 weeks.
4 criterions of therapeutical effect and therapeutic outcome
4.1 clinical total effectses evaluation criteria references《New Chinese medicine guideline of clinical investigations (is tried)》(Zheng Xiao cornels. in
Medicine Clinical Researches of New Drugs guideline (trying) [S]. Beijing:China Medical Science Press, 2002:78-79.) draft.It is clinical
Recovery from illness:Symptom is wholly absent, and main physico-chemical examination index is normal;It is effective:Cardinal symptom disappears, and main physico-chemical examination index is basic
Normally;Effectively:Cardinal symptom disappears substantially, and main physico-chemical examination index makes moderate progress;It is invalid:Compared with pre-treatment, each side
Without improvement.
Before and after 4.2 two groups of treatments, Level of Serum Uric Acid compares
After two groups of treatments, Level of Serum Uric Acid declines, and compares P before and after treatment<0.01, treatment group and matched group comparing difference do not have
Statistically significant P<0.05, refer to table 1:
Before and after 1 two groups of treatments of table, Level of Serum Uric Acid compares
Note * P<0.01
4.3 two groups of Clinical efficacy comparisons
Treatment group's clinical recovery 21, effective 7, effective 1, total effective rate 93.33%;Matched group clinical recovery 10
Example, effective 8, effective 6, total effective rate 80%.Two groups of comparitive studies, difference significance (P<0.05), refer to table 2:
2 two groups of Clinical efficacy comparisons of table
Note * P<0.05
Conclusion (of pressure testing):The present invention has significant therapeutic effect to hyperuricemia and gout.
Presently preferred embodiments of the present invention is the foregoing is only, not to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (6)
1. it is a kind of that the preparation method for preventing and treating hyperuricemia and the medicinal monomer of gout is extracted from Rhizoma Polygoni Cuspidati, it is characterised in that to include
Following steps:
Step one, it is thick to extract:After Rhizoma Polygoni Cuspidati raw material is smashed, the raw material of certain mass is weighed, add 20 times of amount 70% ethanol heating
Backflow 2h after, extract medicinal residues, will in medicinal residues add 15 times amount 70% alcohol heating reflux 1.5h, united extraction liquid, cold preservation 1d,
High speed centrifugation, discards insoluble matter, and vacuum distillation ethanol obtains crude extract to relative density 1.2;
Step 2, thick purification:To 9, cold preservation 1d, high speed centrifugation are concentrated crude extract pH value in sodium hydroxide regulating step one
Liquid, discards insoluble matter, and hydrochloric acid adjusts pH to neutrality, and cold preservation 1d, high speed centrifugation discard insoluble matter, obtain extracting solution;
Step 3, chromatographic column purification:By polyamide resin column on the extracting solution in step 2, static adsorption 2 hours, 20BV water is used
Eluting, discards water elution part, then with different concentration ethanol eluting successively from low to high, differentiates eluent with thin layer chromatography
In whether containing a certain monomer and its relative amount in monomeric compound group, collect the eluent with high accounting target compound
And merge, gained eluent is prepared into into product.
2. a kind of extraction from Rhizoma Polygoni Cuspidati according to claim 1 prevents and treats the preparation side of hyperuricemia and the medicinal monomer of gout
Method, it is characterised in that:In the step one, Rhizoma Polygoni Cuspidati raw material includes that Quercitrin-3-O-glucoside, Quercetin -3-O- are Arabic
One or more in glucosides, Quercetin -3- galactosides.
3. a kind of extraction from Rhizoma Polygoni Cuspidati according to claim 1 prevents and treats the preparation side of hyperuricemia and the medicinal monomer of gout
Method, it is characterised in that:In the step 3, the product of eluent processing includes capsule, tablet and mixture.
4. a kind of extraction from Rhizoma Polygoni Cuspidati according to claim 3 prevents and treats the preparation side of hyperuricemia and the medicinal monomer of gout
Method, it is characterised in that the preparation method of the capsule is:It is concentrated in vacuo, it is vacuum dried or is spray-dried and to obtain fine powder, plus 6 times
20% gelatinized corn starch is measured, is pelletized encapsulated.
5. a kind of extraction from Rhizoma Polygoni Cuspidati according to claim 3 prevents and treats the preparation side of hyperuricemia and the medicinal monomer of gout
Method, it is characterised in that the preparation method of the tablet is:The vacuum drying of gained eluent is spray-dried to obtain fine powder, adds 6 times
Measure 20% gelatinized corn starch, 1 times of amount 10%PVP (polyvidone) ethanol, granulation, drying, tabletting.
6. a kind of extraction from Rhizoma Polygoni Cuspidati according to claim 3 prevents and treats the preparation side of hyperuricemia and the medicinal monomer of gout
Method, it is characterised in that the preparation method of the mixture is:Gained eluent concentrates or is diluted to the extractum of relative density 1.2, dress
Bottle makes oral liquid.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114288337A (en) * | 2022-01-14 | 2022-04-08 | 江苏农牧科技职业学院 | Traditional Chinese medicine composition for preventing and treating gosling gout and preparation method thereof |
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