CN105434598A - Traditional Chinese medicine composition for preventing and treating hypertension, preparation method thereof and preparation - Google Patents
Traditional Chinese medicine composition for preventing and treating hypertension, preparation method thereof and preparation Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for preventing and treating hypertension, a preparation method of the traditional Chinese medicine composition and a preparation. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 25 parts of apocynum venetum, 10 to 25 parts of uncaria rhynchophylla, 5 to 20 parts of radix puerariae, 5 to 20 parts of prunella vulgaris, 3 to 10 parts of semen cassiae, 3 to 15 parts of celery, 3 to 10 parts of flos chrysanthemi indici and 3 to 10 parts of eucommia ulmoides. The traditional Chinese medicine composition prepared by the invention is scientific in formula, can be used for effectively treating hypertension and solves the defects of a traditional Chinese medicine that the effect is taken slowly, the effect is not ideal, the dosage is large, and the like. Through long-term clinical verification, a result shows that the effective rate is up to 97 percent, and the effect is remarkably superior to the curative effect of commercially-available like products and traditional Chinese medicine single agents.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly one is for preventing and treating hypertensive Chinese medicine composition and preparation method thereof, preparation.
Background technology
Hypertension (hypertension) refers to and increases as principal character (systolic pressure >=140 millimetres of mercury with systemic arterial blood pressure (systolic pressure and/or diastolic pressure), diastolic pressure >=90 millimetres of mercury), can with the function of organ or the clinical syndromes of organic lesion such as the heart, brain, kidneys.Hypertension can be divided into two classes clinically: 1. essential hypertension, its be a kind of with blood pressure rising for main clinical manifestation and the not yet clear and definite independent disease of the cause of disease, account for all hyperpietics' more than 90%.2. secondary hypertension, is also called symptomatic hypertension, and in this kind of disease, the cause of disease is clear and definite, and hypertension is only one of clinical manifestation of this kind of disease, and blood pressure can temporary or persistency rising.Hypertensive clinical manifestation varies with each individual.Early stage possibility is asymptomatic or symptom is not obvious, blood pressure only can occur after fatigue, psychentonia, anxious state of mind and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom gradually.Now be called as benign hypertension.Benign hypertension common clinical symptoms has headache, dizziness, absent minded, hypomnesis, numb limbs and tense tendons, nocturia increase, cardiopalmus, uncomfortable in chest, weak etc.Severe headache, vomiting, cardiopalmus, the symptom such as dizzy is even there will be when blood pressure is elevated to a certain degree suddenly, obnubilation, tic can be there is time serious, this just belongs to accelerated hypertension and hypertension critical illness, how can there is infringement and the pathological changes of the organs such as the serious heart, brain, kidney in a short time, as apoplexy, heart infarction, renal failure etc.
Existing antihypertensive drugs comprises: 1. diuretic; 2. beta-blocker; 3. calcium channel blocker; 4. angiotensin converting enzyme inhibitor; 5. hypertensinⅡreceptorretarder.But these medicines all have certain side effect, it is disorderly etc. that side effect as diuretic comprises Nausea and vomiting, headache, diarrhoea, erythra, pruritus, tired, dizzy, blurred vision, muscle spasm, water and eletrolytes, and the side effect of beta-blocker comprises weak, cold extremities, arrhythmia, heart failure etc.And the cycle of taking of Western medicine is long, unstable blood pressure is fixed, easily recurs, and cures the symptoms, not the disease.
Relative to Western medicine, Chinese medicine has better safety, and side effect is little, and the compliance of patient is better.Kendir pressure-reducing sheet, main component comprises Herba Apocyni veneti, Spica Prunellae, Ramulus Uncariae Cum Uncis, Rhizoma Alismatis, Concha Margaritifera, Radix Achyranthis Bidentatae, Fructus Crataegi and Flos Chrysanthemi, and primary efficacy comprises suppressing the hyperactive liver and subsiding YANG, and endogenous wind stopping is invigorated blood circulation, removing obstruction in the collateral to relieve pain.For excessive rising of liver-YANG, obstruction of collaterals by blood stasis, dizzy, dizzy, headache, irritated and hypertension, hyperlipidemia are antihypertensive drugs common on the market.But there is take effect slow, DeGrain, high in cost of production drawback in the Chinese medicine preparation comprising kendir pressure-reducing sheet, patient still has demand for the blood pressure lowering Chinese medicine preparation of good effect, instant effect.
Summary of the invention
In view of this, the invention provides one for preventing and treating hypertensive Chinese medicine composition and preparation method thereof, preparation.This Chinese medicine composition effectively can treat hypertension, instant effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of Chinese medicine composition, with parts by weight, obtained by following crude drug:
Herba Apocyni veneti, another name ambary, bluish dogbane, red building etc., upright fruticuli, high 1.5-3 rice, general height about 2 meters, reaches as high as 4 meters, is grown on the chiltern ground on riverbank, gully, hillside, in Chinese Huaihe River, the Qinling Mountains, to the north of Kun Lun Mountain each province (autonomous region) have Herba Apocyni veneti to distribute, relieve inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis, control the effects such as heart disease.
Ramulus Uncariae Cum Uncis, another name Ramulus Uncariae Cum Uncis, to hang rattan, Wang Gambirplant Branchlet, reversal of the natural order of things perverse etc.Be the evergreen liana of Rubiaceae wild gambier, climb up by holding on to shape shrub, stem branch square column type is very thin without hair, leaf papery ovalize, head inflorescence.Ramulus Uncariae Cum Uncis is used as medicine with the stem branch of buckle, and it has heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion effect.Modern pharmacology experiment also proves that Ramulus Uncariae Cum Uncis has hypotensive effect, therefore has very high medical value.
Radix Puerariae is the dry root of legume pueraria lobata, practises and claims Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry.Sweet, pungent, cool.There is the merit of expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Spica Prunellae, another name: wheat head Spica Prunellae, iron wire Spica Prunellae, Mai Xia is withered, the iron wire summer is withered, sunset sentence, Nedong etc.; For herbaceos perennial, creeping rootstock, raw fibrous root on joint.Stem up to 30 centimetres, base portion multi-branched, lilac.Calyx is bell, and filigree is slightly flat, and style is very thin, and tip sliver bores shape, excurvation.The nearly flat-top of floral disc.Pyrene yellowish-brown, the florescence 4-6 month, the fruit phase 7-10 month.Spica Prunellae growth to be wet thick grass, wasteland, roadside at gully meadow bog or both sides, riverbank, is distributed widely in all over China, economizes as the main place of production with Henan, Anhui, Jiangsu, Hunan etc.Spica Prunellae strong adaptability, seldom has disease and pest in whole growth course.There is the effect of improving eyesight of relieving inflammation or internal heat, can conjunctival congestion and swelling pain, headache etc. be controlled.
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae, have the merit of improving eyesight with it and name it.To gather autumn mature fruit, dry, lay seed, removing impurity.Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, blood pressure lowering, blood fat reducing.
Herba Apii graveolentis, belong to samphire, have Herba Oenanthes Javanicae, Herba Apii graveolentis, Herba Apii graveolentis three kinds, function is close, and medicinal is good with Herba Apii graveolentis.Herba Apii graveolentis fragrance is denseer, claims " medicine celery ".But with Herba Coriandri is not a kind, Herba Apii graveolentis rich in proteins, carbohydrate, carotene, vitamin B group, calcium, phosphorus, ferrum, sodium etc., simultaneously, there is calming liver and clearing heat, expelling wind and removing dampness, relieving restlessness is subsided a swelling, cooling blood for hemostasis, removing toxic substances lung qi dispersing, stomach invigorating profit blood, bowel relieving is convenient, nourishing the lung to arrest cough, reduce blood pressure, effect of brain-strengthening calmness.Often eat Herba Apii graveolentis, especially eat leaf of Herba Apii graveolentis, all very useful to prophylaxis of hypertension, arteriosclerosis etc., and have auxiliary therapeutic action.
Flos Chrysanthemi Indici is Compositae herbaceos perennial, and the capitate profile of Flos Chrysanthemi Indici is similar to Flos Chrysanthemi, spherical in class, diameter 0.3 ~ 1cm, brown color.Involucre is made up of 4 ~ 5 layers of bract.Ligulate flower one is taken turns, and yellow, shrinkage is curling; Tubular flower is most, buff.Body is light.Gas is pungent, bitter in the mouth, slightly poisonous.Wild in wild areas such as patana, Tian Bian, roadsides.Be good with yellow skin without stalk, complete, toil, the non-standard-sized sheet person of flower.Flos Chrysanthemi Indici cold nature, tool dispelling wind and heat pathogens, subduing swelling and detoxicating effect, can treat furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, the disease such as dizzy of having a headache.
The Cortex Eucommiae, is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Its sweet in the mouth, warm in nature.There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, admittedly through antiabortive effect.Can treat the lumbago and skelalgia or aching and limp unable that insufficiency of kidney-YANG causes, born of the same parents' tire that deficiency of liver-QI causes is not solid, the diseases such as scrotum pruritus due to damp pathogen.Be listed in top grade in Shennong's Herbal.The modern study Cortex Eucommiae has rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system, improves leukocyte pharmacological action.
Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Radix Puerariae, Spica Prunellae, Semen Cassiae, Herba Apii graveolentis, Flos Chrysanthemi Indici and the Cortex Eucommiae are made compound medicine by the present invention, scientific formula, effectively can prevent and treat hypertension, and instant effect, its compound recipe Be very effective is better than single dose effect, and antihypertensive effect is better than existing Chinese medicine preparation.
In embodiments more provided by the invention, with parts by weight, obtained by following crude drug:
In other embodiments provided by the invention, with parts by weight, obtained by following crude drug:
In other embodiments provided by the invention, with parts by weight, obtained by following crude drug:
Present invention also offers the application of this Chinese medicine composition in preparation control hypertension drug; With parts by weight, this Chinese medicine composition is obtained by following crude drug:
Present invention also offers the preparation method of this Chinese medicine composition, comprising: Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Radix Puerariae, Spica Prunellae, Semen Cassiae, Herba Apii graveolentis, Flos Chrysanthemi Indici and the Cortex Eucommiae are carried out alcohol extraction, obtain Chinese medicine composition; With parts by weight, this Chinese medicine composition is obtained by following crude drug:
As preferably, alcohol extraction is: the ethanol water adding 5 ~ 10 times of crude drug weight carries out reflux, extract, and the number of times of reflux, extract, is 2 ~ 4 times, and the time of each reflux, extract, is 2 ~ 4h.
In embodiments more provided by the invention, alcohol extraction is: the ethanol water adding 5 times of crude drug weight carries out reflux, extract, and the number of times of reflux, extract, is 3 times, and the time of each reflux, extract, is 3h.
As preferably, the volumn concentration of ethanol water is 60% ~ 90%.
In embodiments more provided by the invention, the volumn concentration of ethanol water is 70%.
In embodiments more provided by the invention, also comprise reduced vacuum after alcohol extraction and concentrate or spray-dired step.
Present invention also offers a kind of Chinese medicine preparation, comprise pharmaceutically acceptable adjuvant and Chinese medicine composition provided by the invention; With parts by weight, this Chinese medicine composition is obtained by following crude drug:
As preferably, the dosage form of Chinese medicine preparation is decoction, unguentum, pill, powder, capsule, granule, tablet, oral liquid or injection.
The invention provides a kind of for preventing and treating hypertensive Chinese medicine composition and preparation method thereof, preparation.With parts by weight, this Chinese medicine composition is obtained by Herba Apocyni veneti 10 ~ 25 parts, Ramulus Uncariae Cum Uncis 10 ~ 25 parts, Radix Puerariae 5 ~ 20 parts, Spica Prunellae 5 ~ 20 parts, Semen Cassiae 3 ~ 10 parts, Herba Apii graveolentis 3 ~ 15 parts, Flos Chrysanthemi Indici 3 ~ 10 parts, the Cortex Eucommiae 3 ~ 10 parts.The present invention at least has one of following advantage:
1, the Chinese medicine composition scientific formula that obtains of the present invention, effectively can treat hypertension, solve Chinese medicine and take effect slowly, effect is undesirable, dose is large wait not enough.Verified by Long-term clinical, result shows efficiency can up to 97%, and Be very effective is better than commercial like product and Chinese medicine single dose curative effect;
2, extraction process of the present invention makes the active ingredient of its blood pressure lowering obtain higher yield, preparation technology's science, simple and easy, and preparation cost is low.
Detailed description of the invention
The invention discloses one for preventing and treating hypertensive Chinese medicine composition and preparation method thereof, preparation, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
Provided by the inventionly all can be buied by market for preventing and treating raw materials used medicine or adjuvant in hypertensive Chinese medicine composition and preparation method thereof, preparation.
Below in conjunction with embodiment, set forth the present invention further:
The extraction of embodiment 1 Chinese medicine composition
With parts by weight, the crude drug of the present embodiment Chinese medicine composition comprises:
Extracting method: each component in prescription is put into multifunctional extracting pot, adds 5 times amount 70% ethanol and carries out reflux, extract, reflux, extract, 3 times, each 3 hours.Merge extractive liquid, filter, reduced vacuum concentrates, and obtains required extract.
The extraction of embodiment 2 Chinese medicine composition
With parts by weight, the crude drug of the present embodiment Chinese medicine composition comprises:
Extracting method: each component in prescription is put into multifunctional extracting pot, adds 5 times amount 70% ethanol and carries out reflux, extract, reflux, extract, 3 times, each 3 hours.Merge extractive liquid, filter, reduced vacuum concentrates, and obtains required extract.
The extraction of embodiment 3 Chinese medicine composition
With parts by weight, the crude drug of the present embodiment Chinese medicine composition comprises:
Extracting method: each component in prescription is put into multifunctional extracting pot, adds 5 times amount 70% ethanol and carries out reflux, extract, reflux, extract, 3 times, each 3 hours.Merge extractive liquid, filter, reduced vacuum concentrates, and obtains required extract.
The antihypertensive effect test of embodiment 4 Chinese medicine composition
The obtained Chinese medicine composition of Example 1 ~ 3 carries out efficacy of antihypertensive treatment observation with Chinese medicine single dose and commercially available kendir pressure-reducing sheet, and it is routine that test group 1 ~ 3 and matched group 1 often organizes hyperpietic each 100, and it is routine that matched group 2 ~ 9 often organizes hyperpietic each 50.Grouping situation is as follows:
Test group 1: take embodiment 1 Chinese medicine composition, dose is 2g/ days;
Test group 2: take embodiment 2 Chinese medicine composition, dose is 2g/ days;
Test group 3: take embodiment 3 Chinese medicine composition, dose is 2g/ days;
Matched group 1: take kendir pressure-reducing sheet, dose is 6g/ days;
Matched group 2: take Herba Apocyni veneti ethanol extract, dose is 3.5g/ days;
Matched group 3: take Ramulus Uncariae Cum Uncis ethanol extract, dose is 3.5g/ days;
Matched group 4: take Radix Puerariae ethanol extract, dose is 3.5g/ days;
Matched group 5: take Spica Prunellae ethanol extract, dose is 3.5g/ days;
Matched group 6: take Semen Cassiae ethanol extract, dose is 3.5g/ days;
Matched group 7: take Herba Apii graveolentis ethanol extract, dose is 3.5g/ days;
Matched group 8: take chrysanthemol extract, dose is 3.5g/ days;
Matched group 9: take eucommoil extract, dose is 3.5g/ days;
Wherein, the preparation method of the Chinese medicine single dose ethanol extract in matched group 2 ~ 9 is consistent with the extracting method of embodiment 1 ~ 3 product.
The curative effect that said medicine was taken after 1 month sees the following form:
Table 1 antihypertensive effect comparing result
From above-mentioned test data, when dose is less, the antihypertensive effect of Chinese medicine composition provided by the invention is significantly better than the antihypertensive effect of commercially available antihypertensive product and Chinese medicine single dose.
The preparation of embodiment 5 capsule
The formula of capsule:
Embodiment 1 extract dry powder 160kg;
Starch 40kg.
Preparation method: get above-mentioned two kinds of compositions and put in mixer and mix; time is 30 ~ 45 minutes; add water and stir; granulate with granulation machine, dry after crossing 30 mesh sieve granulate, carry out granulate again after drying; removing powder fractions; put in automatic capsule machine and fill, adopt No. 0 Capsules, fill 0.5 gram of granule for every.Fill complete, pack and get final product.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition, is characterized in that, with parts by weight, is obtained by following crude drug:
2. Chinese medicine composition according to claim 1, is characterized in that, with parts by weight, is obtained by following crude drug:
3. Chinese medicine composition according to claim 1, is characterized in that, with parts by weight, is obtained by following crude drug:
4. Chinese medicine composition according to claim 1, is characterized in that, with parts by weight, is obtained by following crude drug:
5. the application of Chinese medicine composition in preparation control hypertension drug according to any one of Claims 1-4.
6. the preparation method of Chinese medicine composition according to any one of Claims 1-4, is characterized in that, comprising: Herba Apocyni veneti, Ramulus Uncariae Cum Uncis, Radix Puerariae, Spica Prunellae, Semen Cassiae, Herba Apii graveolentis, Flos Chrysanthemi Indici and the Cortex Eucommiae are carried out alcohol extraction, obtains Chinese medicine composition.
7. preparation method according to claim 6, is characterized in that, described alcohol extraction is: the ethanol water adding 5 ~ 10 times of crude drug weight carries out reflux, extract, and the number of times of reflux, extract, is 2 ~ 4 times, and the time of each reflux, extract, is 2 ~ 4h.
8. preparation method according to claim 6, is characterized in that, the volumn concentration of described ethanol water is 60% ~ 90%.
9. a Chinese medicine preparation, is characterized in that, comprises pharmaceutically acceptable adjuvant and Chinese medicine composition according to any one of Claims 1-4.
10. Chinese medicine preparation according to claim 9, is characterized in that, the dosage form of described Chinese medicine preparation is decoction, unguentum, pill, powder, capsule, granule, tablet, oral liquid or injection.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186830A (en) * | 2018-03-21 | 2018-06-22 | 楚雄医药高等专科学校 | A kind of broad bean flower blood-pressure decreasing tea and preparation method thereof and drinking method |
| CN113663031A (en) * | 2021-09-15 | 2021-11-19 | 荔波荔泉民族医药有限公司 | Formula of blood pressure lowering medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186830A (en) * | 2018-03-21 | 2018-06-22 | 楚雄医药高等专科学校 | A kind of broad bean flower blood-pressure decreasing tea and preparation method thereof and drinking method |
| CN113663031A (en) * | 2021-09-15 | 2021-11-19 | 荔波荔泉民族医药有限公司 | Formula of blood pressure lowering medicine |
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