CN105232919A - Traditional Chinese medicine composition for treating child bronchopneumonia and preparing method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating child bronchopneumonia and a preparing method thereof. The traditional Chinese medicine composition is prepared from, by weight, 3 parts to 19 parts of fritillaria cirrhosa, 10 parts to 30 parts of scorched hawthorn fruits, 10 parts to 20 parts of immature bitter oranges, 5 parts to 20 parts of trichosanthes kirilowii, 6 parts to 12 parts of folium eriobotryae, 4 parts to 10 parts of semen raphani, 3 parts to 10 parts of semen lepidii, 5 parts to 15 parts of fructus forsythiae, 12 parts to 14 parts of mangnolia officinalis, 4 parts to 8 parts of periostracum cicadas, 15 parts to 33 parts of pear peels, 10 parts to 20 parts of Chinese dates, 8 parts to 17 parts of folium artemisiae argyi, 5 parts to 10 parts of lotus seeds, 5 parts to 13 parts of aloe and 7 parts to 13 parts of folium mori. The traditional Chinese medicine composition is prepared by mixing the traditional Chinese medicinal materials in a certain weight proportion, the multiple medicinal materials are properly matched, finally granules convenient to take are prepared, and the prepared granules have the effects of dispelling cold, facilitating the lung, clearing the lung and eliminating phlegm; the treatment effect on the pneumonia is good, the effect taking speed is high, safe and reliable effects are achieved, the toxic and side effects are low, taking is easy, and the good treatment effect is achieved on the child bronchopneumonia, bronchopneumonia and asthma. The preparing technology of the medicine composition is simple and suitable for industrial mass production.

Description

One treats children's bronchopneumonia Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and preparation method for the treatment of children's bronchopneumonia.

Background technology

Infant is pillar of the state, following groundwork person especially, along with the change of life and the change of diet structure, the disease of its life and health is threatened constantly to threaten growing up healthy and sound of infant, wherein bronchopneumonia is exactly comparatively common one, children's bronchopneumonia is the main commonly encountered diseases of one of children's, is especially more common in infant, is also cradle major causes of death.When bronchopneumonia is born in Winter-Spring cold season and weather cataclysm also known as lobular pneumonia pneumonia is multiple, summer, incidence rate was comparatively low.But it is not this does not represent and would not occur summer, lasting in the more ill rear immunity of morbidity in summer on the contrary in the South China of China, be easy to cause superinfection phenomenon.

Specifically, children's bronchopneumonia is also known as children's's lobular pneumonia, be the common disease of infant, the syndrome that initial performance normally causes as the viral infection such as common cold, influenza and occurring also is likely that the bacteriological infection produced by environmental factors caused.First there is the symptoms such as upper respiratory tract infection in Acute toxic effect, also can dry cough frequently suddenly mostly, occurs secretions afterwards, because infant can not be coughed up phlegm, mostly to swallow through pharyngeal.Mild infant is without obvious sign, and children with serious disease has more existing repeatability hyperpyrexia, is off one's feed, and the phenomenons such as poor sleeping quality, even occur the related symptoms such as digestive tract hemorrhage.As treatment or malpractice very easily occur serious consequence not in time.

In traditional Drug therapy, normal based on antiviral drugs, but prolonged application easily causes the side effect such as infantile diarrhea, allergic rash, acute and chronic gastritis enteritis, even occur that hemoglobin declines, the symptom such as hemolytic anemia, immunosuppressant, and such medicine easily produces drug resistance, at present, the method of domestic and international treatment asthma in children is more, and as western medical treatment method, common medicine has Chuan Le Ning, salbutamol, budesonide etc.; As Chinese traditional treatment method, common medicine has that tongxuan lifei pills, powerful cough with asthma relax, Bulbus Fritillariae Uninbracteatae cough pill etc.But, be difficult to reach satisfied effect in cure rate, treatment means, medical expense etc.

Summary of the invention:

For the defect of prior art, the present invention be directed to the present situation for the treatment of children's bronchopneumonia at present, provide a kind of without Western medicine, effect is better, the Chinese medicine preparation granule that side effect is little.Specifically, the present invention realizes like this.

First object inventor of the present invention provides a kind of prescriptions of Chinese medicine for the treatment of children's bronchopneumonia according to drug matching experience, each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, described formula and weight portion are: Bulbus Fritillariae Cirrhosae 3-19 part, Fructus Crataegi (parched to brown) 10-30 part, Fructus Aurantii Immaturus 10-20 part, Fructus Trichosanthis 5-20 part, Pi is leaf 6-12 part, Semen Raphani 4-10 part, Semen Lepidii (Semen Descurainiae) 3-10 part, Fructus Forsythiae 5-15 part, Cortex Magnoliae Officinalis 12-14 part, Periostracum Cicadae 4-8 part, Pericarpium Pyri 15-33 part, Fructus Jujubae 10-20 part, Folium Artemisiae Argyi 8-17 part, Semen Nelumbinis 5-10 part, Aloe 5-13 part, Folium Mori 7-13 part.

Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Bulbus Fritillariae Cirrhosae 11 parts, Fructus Crataegi (parched to brown) 15 parts, Fructus Aurantii Immaturus 15 parts, Fructus Trichosanthis 10 parts, Pi are 8 parts, leaf, Semen Raphani 7 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Fructus Forsythiae 8 parts, Cortex Magnoliae Officinalis 11 parts, Periostracum Cicadae 8 parts, Pericarpium Pyri 15 parts, 20 parts, Fructus Jujubae, Folium Artemisiae Argyi 8 parts, 6 parts, Semen Nelumbinis, Aloe 8 parts, 7 parts, Folium Mori.

Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, most preferred formula is: Bulbus Fritillariae Cirrhosae 14 parts, Fructus Crataegi (parched to brown) 13 parts, Fructus Aurantii Immaturus 12 parts, Fructus Trichosanthis 11 parts, Pi are 8 parts, leaf, Semen Raphani 7 parts, Semen Lepidii (Semen Descurainiae) 4 parts, Fructus Forsythiae 7 parts, Cortex Magnoliae Officinalis 13 parts, Periostracum Cicadae 5 parts, Pericarpium Pyri 23 parts, 17 parts, Fructus Jujubae, Folium Artemisiae Argyi 9 parts, 7 parts, Semen Nelumbinis, Aloe 7 parts, 8 parts, Folium Mori.

Second object of the present invention is, the mechanism of each medicine in formula is provided, with Bulbus Fritillariae Cirrhosae in side of the present invention, Fructus Trichosanthis is monarch drug, a main clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize laxation and be mainly used in lung-heat type cough, the few expectorant of dry cough, treatment tracheitis there is special effect, with Pi leaf, Semen Lepidii (Semen Descurainiae), Periostracum Cicadae, Pericarpium Pyri, Semen Nelumbinis, Aloe, Fructus Forsythiae, Folium Mori are ministerial drug, ministerial drug major part is cold, dispel lung-heat, clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI is helped, effect of further increase monarch drug, with Fructus Crataegi (parched to brown), Semen Raphani, Cortex Magnoliae Officinalis, Fructus Jujubae, Folium Artemisiae Argyi is adjuvant drug, promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, can effectively prevent the thing in Great Cold from damaging health, with Fructus Aurantii Immaturus for making medicine, dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm leads each medicine to arrive lesions position.

The function of each taste Chinese crude drug used in the Chinese medicine composition for the treatment of eczema of the present invention is as follows:

Bulbus Fritillariae Cirrhosae: bitter in the mouth, cold in nature.

Gui Jing: return lung, heart channel.

Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, for lung-heat type cough, and the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.

Fructus Crataegi (parched to brown): sour in the mouth, warm in nature.

Gui Jing: return spleen, stomach, Liver Channel.

Function cures mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.

Fructus Aurantii Immaturus: bitter in the mouth, warm in nature.

Gui Jing: return spleen, stomach warp.

Function cures mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.

Fructus Trichosanthis: sweet in the mouth, cold in nature.

Gui Jing: return lung, stomach, large intestine channel.

Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

Folium Eriobotryae: bitter in the mouth, cold in nature.

Gui Jing: attach to the lung and stomach meridians.

Function cures mainly: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.

Semen Raphani: acrid in the mouth, property is put down.

Gui Jing: return lung, spleen, stomach warp.

Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.

Semen Lepidii (Semen Descurainiae): acrid in the mouth, cold in nature.

Gui Jing: return lung, urinary bladder channel.

Function cures mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.

Folium Forsythiae: cool in nature, bitter in the mouth,

Gui Jing: enter the heart, liver, gallbladder meridian.

Effect: heat-clearing and toxic substances removing, effect of mass dissipating and swelling eliminating.

Clinical practice: this product has prevention and therapy hepatic injury or liver failure clinical, or be used for treating pulmonary abscess.

Cortex Magnoliae Officinalis: bitter in the mouth, warm in nature.

Gui Jing: return spleen, stomach, lung, large intestine channel.

Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.

Periostracum Cicadae: sweet in the mouth, cold in nature.

Gui Jing: return lung, Liver Channel.

Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic, for anemopyretic cold, and pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.

Pericarpium Pyri: sweet in the mouth, cool in nature.

Gui Jing: lung; The heart; Kidney; Large intestine channel.

Function cures mainly: clearing away heart-fire and moistening the lung; Pathogenic fire reducing promotes the production of body fluid, and separates sore.Main summer-heat excessive thirst; Xeropulmonary cough; Spit blood; Dysentery; ; Scabies;

Carbuncle on the back; Furuncle.

Fructus Jujubae: sweet in the mouth, warm in nature.

Gui Jing: enter spleen, stomach warp.

Function cures mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, and for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria, circulation of qi promoting, menoxenia, redly collapses, leucorrhea.

Semen Nelumbinis: sweet in the mouth, property is put down.

Gui Jing: return spleen, kidney, heart channel.

Function cures mainly: spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.For insufficiency of the spleen chronic diarrhea, seminal emission leukorrhagia, palpitation and insomnia.

Aloe: bitter in the mouth, cold in nature.

Gui Jing: return liver, stomach, large intestine channel.

Function cures mainly: the dizziness of Liver Channel excess-heat, headache, tinnitus, agitation, constipation, pediatric epilepsy scared, infantile malnutrition, catharsis and toxin expelling.

Folium Artemisiae Argyi: bitter in the mouth, warm in nature.

Gui Jing: return liver,spleen,kidney warp.

Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.

Folium Mori: sweet in the mouth, cold in nature.

Gui Jing: return lung, Liver Channel.

Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, and for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.

3rd object of the present invention is to provide a kind of preparation method for the treatment of children's bronchopneumonia, comprises the steps:

By prescription

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) get mixture and the cyclodextrin of step (3), weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:1.5-2.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, dry, obtains granule.

Medicine of the present invention is mainly used to treatment treatment infantile bronchitis, bronchopneumonia and asthma, is particularly applicable to treatment infantile bronchitis.

The medicine for the treatment of children's bronchopneumonia of the present invention compared with prior art, has following advantage:

(1) the present invention is mixed according to the weight ratio that Chinese crude drug is certain, multi-medicament is suitably coordinated, and be finally prepared into the granule of taking convenience, there is cold expelling lung qi dispersing, the effect of removing heat from the lung and dissipating phlegm, treatment pneumonia good effect, instant effect, safe and reliable, the feature that toxic and side effects is little, take simple, have good therapeutic effect to infantile bronchitis, bronchopneumonia and asthma.

(2) treatment by Chinese herbs clear mechanism of the present invention, be especially applicable to treating invasion of pathogen toward the interior, aggravation, the bronchitis of initiation, auscultation two pulmonary respiration sound is thick, and have asthma sound, severe patient hears the diseases such as dry moist rale.

(3) pharmaceutical preparation of the present invention is simple, is applicable to industrialized great production.

Specific embodiment:

Embodiment 1:

Bulbus Fritillariae Cirrhosae 3 grams, Fructus Crataegi (parched to brown) 10 grams, Fructus Aurantii Immaturus 10 grams, Fructus Trichosanthis 5 grams, Pi 6 grams, leaf, Semen Raphani 4 grams, Semen Lepidii (Semen Descurainiae) 3 grams, Fructus Forsythiae 5 grams, Cortex Magnoliae Officinalis 12 grams, Periostracum Cicadae 4 grams, Pericarpium Pyri 15 grams, 10 grams, Fructus Jujubae, Folium Artemisiae Argyi 8 grams, 5 grams, Semen Nelumbinis, Aloe 5 grams, 7 grams, Folium Mori.

Treat a Chinese medicine composition for infantile bronchitis, its preparation method is as follows:

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) get mixture and the cyclodextrin of step (3), weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:1.5-2.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, dry, obtains granule.

Embodiment 2

Bulbus Fritillariae Cirrhosae 19 grams, Fructus Crataegi (parched to brown) 30 grams, Fructus Aurantii Immaturus 20 grams, Fructus Trichosanthis 20 grams, Pi are 12 grams, leaf, Semen Raphani 10 grams, Semen Lepidii (Semen Descurainiae) 10 grams, Fructus Forsythiae 15 grams, Cortex Magnoliae Officinalis 14 grams, Periostracum Cicadae 8 grams, Pericarpium Pyri 33 grams, 20 grams, Fructus Jujubae, Folium Artemisiae Argyi 17 grams, 10 grams, Semen Nelumbinis, Aloe 13 grams, 13 grams, Folium Mori

Treat a Chinese medicine composition for infantile bronchitis, its preparation method is as follows:

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) get mixture and the cyclodextrin of step (3), weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:1.5-2.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, dry, obtains granule.

Embodiment 3

Bulbus Fritillariae Cirrhosae 11 grams, Fructus Crataegi (parched to brown) 15 grams, Fructus Aurantii Immaturus 15 grams, Fructus Trichosanthis 10 grams, Pi 8 grams, leaf, Semen Raphani 7 grams, Semen Lepidii (Semen Descurainiae) 7 grams, Fructus Forsythiae 8 grams, Cortex Magnoliae Officinalis 11 grams, Periostracum Cicadae 8 grams, Pericarpium Pyri 15 grams, 20 grams, Fructus Jujubae, Folium Artemisiae Argyi 8 grams, 6 grams, Semen Nelumbinis, Aloe 8 grams, 7 grams, Folium Mori

Treat a Chinese medicine composition for infantile bronchitis, its preparation method is as follows:

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) get mixture and the cyclodextrin of step (3), weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:1.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, dry, obtains granule.

Embodiment 4

Bulbus Fritillariae Cirrhosae 14 grams, Fructus Crataegi (parched to brown) 13 grams, Fructus Aurantii Immaturus 12 grams, Fructus Trichosanthis 11 grams, Pi 8 grams, leaf, Semen Raphani 7 grams, Semen Lepidii (Semen Descurainiae) 4 grams, Fructus Forsythiae 7 grams, Cortex Magnoliae Officinalis 13 grams, Periostracum Cicadae 5 grams, Pericarpium Pyri 23 grams, 17 grams, Fructus Jujubae, Folium Artemisiae Argyi 9 grams, 7 grams, Semen Nelumbinis, Aloe 7 grams, 8 grams, Folium Mori

Treat a Chinese medicine composition for infantile bronchitis, its preparation method is as follows:

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) get mixture and the cyclodextrin of step (3), weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:2.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, dry, obtains granule.

Embodiment 5

Bulbus Fritillariae Cirrhosae 14 grams, Fructus Crataegi (parched to brown) 13 grams, Fructus Aurantii Immaturus 12 grams, Fructus Trichosanthis 11 grams, Pi 8 grams, leaf, Semen Raphani 7 grams, Semen Lepidii (Semen Descurainiae) 4 grams, Fructus Forsythiae 7 grams, Cortex Magnoliae Officinalis 13 grams, Periostracum Cicadae 5 grams, Pericarpium Pyri 23 grams, 17 grams, Fructus Jujubae, Folium Artemisiae Argyi 9 grams, 7 grams, Semen Nelumbinis, Aloe 7 grams, 8 grams, Folium Mori

Treat a Chinese medicine composition for infantile bronchitis, its preparation method is as follows:

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) mixture and the cyclodextrin of step (3) is got, weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:1.5-2.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, incapsulate after drying, obtain capsule.

Embodiment 6

1) clinical data:

The present inventor in 2010 so far, carries out clinical observation treatment to 427 routine infantile bronchitiss, bronchopneumonia and asthmatic patient, wherein, man 214 example, female 213 example, the age be 0-5 year, the mean age is 2 years old.

2) Therapeutic Method:

Treatment group is group 1.: the granule taking the embodiment of the present invention 3, and every day, 5g, took at twice, within two hours after meal, takes medicine, and sooner or later respectively once, within 10 days, is a course for the treatment of; Men and women is 71 people.

Treatment group is group 2.: the granule taking the embodiment of the present invention 4, and every day, 5g, took at twice, within two hours after meal, takes medicine, and sooner or later respectively once, within 10 days, is a course for the treatment of; Men and women is 71 people.

Observation group: oral Radix Glycyrrhizae tabellae, serious gram of transfusion azithromycin treatment 10 days is a course for the treatment of, male 71 people, female 72 people.

3) curative effect determinate standard:

Cure: the classical symptom such as pneumonia, bronchus all disappears, pulmonary's rale disappears, and x-ray check pulmonary lesions absorbs, and hemogram recovers normal.

Effective: the state of an illness is obviously improved, symptom obviously alleviates, and pulmonary's rale reduces, and x-ray check pulmonary lesions does not absorb completely.

Invalid: by treating rear symptom and sign all without improvement or increase the weight of.

Effective percentage: (cure+effective)/this group individual patients.

4) therapeutic effect:

Clinical treatment group 1. group, 2. treatment group organizes healing 219 example, effective 59 examples; Effective 140 examples, account for more than 98%; Observation group cures 80 examples, effective 23 examples, invalid 20 examples, total effective rate 86.01%.Detailed results is in table 1.

The therapeutic effect of table 1 treatment group and observation group compares

In addition, after the drug treatment of 10 days, in matched group infant, 5 people suffer from infantile diarrhea, and 10 people vomit phenomenon obviously, 1 people's stomachache, and adverse reaction rate reaches 11.19%; In test group infant, only 1 people suffers from infantile diarrhea and 1 people to vomit phenomenon obvious, do not suffer from erythra, without the untoward reaction of vomiting, shiver with cold high heat, stomachache and skin allergy, adverse reaction rate is only 1.40%, empirical tests, the present invention prepares simply, good absorbing effect, evident in efficacy, have no side effect, safety is high, is conducive to patient and alleviates condition of illness in time.

5) model case:

Case 1: Wang, female, 3 months, people from Linyi, Shandong, infant is in hospital because constantly coughing, and is diagnosed as children's bronchopneumonia on inspection and is in hospital, local county people's hospital hospitalization 6 days, still invalidly to examine, check lung rale sound through I institute doctor, slightly breathe heavily, take the granule of embodiments of the invention 3, each 2.5g, every day twice, and warm water delivery service, after 5 days, found that to only have a little rale, the mental status is relatively good, continues again to take 3 days, and patient returns to one's perfect health.

Case 2: clump, female, 8 months, Shandong region people, infant cough does not stop, and ate multi-medicament, the Chinese medicine and western medicine such as infantile asthma granule all used, and did not all take a turn for the better, seen Duo Jia hospital, be diagnosed as children's bronchopneumonia, and with the fever of 37-38 degree Celsius, diet is bad, spirit is general, introduces through friend, to our hospital, give the Drug therapy of the embodiment of the present invention 1, after taking 7 days, symptom takes a turn for the better to some extent, after continuing to take 7 days, infant transference cure, recovery from illness.

Case 3: Yuan, man, 2 one full year of life, Shan Dongluo people from village, infant is examined as lung is in hospital in children's hospital because of cough, after hospitalization 7 days, poor effect, cough does not stop, and the two lung of rale auscultation is covered with rale sound, spirit is poor, constantly has a fever, and introduces my institute's treatment through friend, give the Drug therapy of the embodiment of the present invention 2, after taking 7 days, symptom takes a turn for the better to some extent, after continuing to take 7 days, infant transference cure, recovery from illness.

Case 4: high certain, man, 18 months, Lianyungang of Jiangsu people, infant is treated in children's hospital because of hand-foot-mouth disease, after treating 3 days, there is cough phenomenon in infant, through blood routine examination, find that there is mycoplasma therefore adopt injection azithromycin, afterwards because vomiting phenomenon is serious, the larger drug withdrawal of side effect, introduces my institute's treatment through relative, take the granule of the embodiment of the present invention 1, after taking 7 days, symptom takes a turn for the better to some extent, and cough phenomenon disappears substantially, after continuing to take 7 days, infant mycoplasma disappears, and cough disappears, recovery from illness.

Case 5: Liu, female, 22 months, people from Zaozhuang, Shandong, because of cough, Bu Tinglaiwo institute checks, the two pulmonary respiration sound of auscultation is coarse, and spirit is poor, and diet is bad, clap rabat in the People's Hospital, be diagnosed as bronchopneumonia, the People's Hospital's infusion treatment 8 days, poor effect carrys out my institute's treatment, takes the Granules in Treating of Medications Example 2 of the present invention, and cough phenomenon stops, the mental status takes a turn for the better, and appetite increases, and continues to take 7 days, the two pulmonary respiration sound of infant disappears substantially, and it is obvious that body weight increases trend, recovery from illness.

The above; be only the specific embodiment of the present invention, protection scope of the present invention is not limited thereto, and is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should define with claim is as the criterion.

Claims (6)

1. treat the Chinese medicine composition of children's bronchopneumonia for one kind, it is characterized in that, be made up of the crude drug of following weight portion: Bulbus Fritillariae Cirrhosae 3-19 part, Fructus Crataegi (parched to brown) 10-30 part, Fructus Aurantii Immaturus 10-20 part, Fructus Trichosanthis 5-20 part, Pi are leaf 6-12 part, Semen Raphani 4-10 part, Semen Lepidii (Semen Descurainiae) 3-10 part, Fructus Forsythiae 5-15 part, Cortex Magnoliae Officinalis 12-14 part, Periostracum Cicadae 4-8 part, Pericarpium Pyri 15-33 part, Fructus Jujubae 10-20 part, Folium Artemisiae Argyi 8-17 part, Semen Nelumbinis 5-10 part, Aloe 5-13 part, Folium Mori 7-13 part.

2. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Bulbus Fritillariae Cirrhosae 11 parts, Fructus Crataegi (parched to brown) 15 parts, Fructus Aurantii Immaturus 15 parts, Fructus Trichosanthis 10 parts, Pi are 8 parts, leaf, Semen Raphani 7 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Fructus Forsythiae 8 parts, Cortex Magnoliae Officinalis 11 parts, Periostracum Cicadae 8 parts, Pericarpium Pyri 15 parts, 20 parts, Fructus Jujubae, Folium Artemisiae Argyi 8 parts, 6 parts, Semen Nelumbinis, Aloe 8 parts, 7 parts, Folium Mori.

3. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Bulbus Fritillariae Cirrhosae 14 parts, Fructus Crataegi (parched to brown) 13 parts, Fructus Aurantii Immaturus 12 parts, Fructus Trichosanthis 11 parts, Pi are 8 parts, leaf, Semen Raphani 7 parts, Semen Lepidii (Semen Descurainiae) 4 parts, Fructus Forsythiae 7 parts, Cortex Magnoliae Officinalis 13 parts, Periostracum Cicadae 5 parts, Pericarpium Pyri 23 parts, 17 parts, Fructus Jujubae, Folium Artemisiae Argyi 9 parts, 7 parts, Semen Nelumbinis, Aloe 7 parts, 8 parts, Folium Mori.

4. prepare a preparation method for the Chinese medicine composition described in any one of claim 1-3, it is characterized in that, concrete step is:

(1) Cortex Magnoliae Officinalis, Bulbus Fritillariae Cirrhosae, Fructus Aurantii Immaturus are carried out pulverization process, grind into powder, cross 180 orders and obtain fine powder, for subsequent use;

(2) amount take clean up Fructus Crataegi (parched to brown), Fructus Trichosanthis, Pi leaf, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Forsythiae, Periostracum Cicadae, Pericarpium Pyri, Fructus Jujubae, Folium Artemisiae Argyi, Semen Nelumbinis, Aloe, Folium Mori merge, and decoct with water twice, and first time adds water as 12 times amount of medical material weight, the boiled 15min of intense fire, slow fire boiling 1.5h, second time adds water as 6 times amount of medical material weight, intense fire boiled slow fire boiling immediately 1.5h, collecting decoction, for subsequent use;

(3) collecting decoction of step (2) being placed in relative density when to be evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C is the extractum of 1.15, then mixs homogeneously with the fine powder of step (1), for subsequent use;

(4) get mixture and the cyclodextrin of step (3), weight consumption ratio is, the mixture of step (3): cyclodextrin is 1:1.5-2.5, add 50% alcoholic solution soft material of 3% appropriate hypromellose, 16-20 order is granulated, dry, obtains granule.

5. Chinese medicine composition according to claim 1, is characterized in that: the application of described Chinese medicine composition in the medicine of preparation treatment infantile bronchitis, bronchopneumonia and asthma.

6. Chinese medicine composition according to claim 1, is characterized in that: the application of described Chinese medicine composition in the medicine of preparation treatment children's bronchopneumonia.