CN104147094A - Children's bronchitis syrup and preparation method thereof - Google Patents
Children's bronchitis syrup and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a children's bronchitis syrup, which is prepared from the following raw materials by are weight: 0.8-1.2 parts of carbetapentane citrate, 6-9 parts of ammonium chloride, 45-60 parts of Berberis thunbergii, 62-80 parts of sunglo, 32-45 parts of Platycodon grandiflorum, 4-10 parts of sodium benzoate, 30-40 parts of an extractum glycyrrhizae liquidum 280-360 parts of carbohydrate and the balance of water. The invention has the following benefit effects: the syrup has definite therapeutic effect fast effectiveness and no toxic or side effect; the preparation method is easy and simple for production operation; the syrup is convenient for storage and transport; the medicinal herbs resources are easily available, so as to mitigate the burden of patient; and the syrup has sweet taste and small dosage, and is easily accepted by the children.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of infantile bronchitis syrup and preparation method thereof.
Background technology
Infantile bronchitis means that bronchus is inflamed, it is common, the multiple respiratory disorder of department of pediatrics, in 1-6 month infant, incidence rate is higher, often by antibacterial, mycoplasma, viral infection or many factors concurrent infection, is caused, and wherein due to viral infection, infantile bronchitis is the most common.This disease clinical manifestation is mainly watery nasal discharge, cough, itching throat, pulmonary's moist rale, heating etc., if treatment not in time or not thorough, easily cause chronic bronchitis, emphysema, pulmonary heart disease, bronchopneumonia and bronchiectasis etc., infant physical and mental health is caused and had a strong impact on.Infantile bronchitis belongs to the syndrome of dyspnea, cough category in the traditional Chinese medical science, under virus or antibacterial etc. infect, can cause stimulation to infant bronchial mucosa, finally causes inflammation.Infant, because respiratory tract tube chamber is relatively narrow and mucosa is soft, has the lymph vessels of enriching, and is easy to cause infection problems; Meanwhile, poor because of its fiber swing ability, if mucous gland secretion is less, can cause air flue dry, affect the growth of pulmonary's elastic fibers, so its coughing up of sputum ability is far weaker than adult.Infantile bronchitis primary treatment object is alleviated bronchial muscular spasm, guarantees its respiratory smooth.
Chinese medicine thinks, infantile bronchitis belongs to " cough with asthma " category, take and coughs, coughs up phlegm or accompany and pant as principal character.Exopathogenic factor be affected by the cold, the heresy of wind heat, endogenous cause of ill is lung spleen renal dysfunction.Children's's internal organs are tender and lovely, and shape gas does not fill, and skin is weak, and failure of defensive QI to protect the body against pathogen is easily wind and cold, the invasion and attack of wind heat exopathogen, impairment of dispersing and descending function of the lung, and lung qi closing are cough with asthma.Cold having the property of coagulation, the lung being the upper source of fluids, wind-cold affecting lung is shown in and coughs uttering phlegm.Wind-heat troubling, decocts bright body fluid, and expectoration Huang is thick; Or because of children's's internal organs tender and lovely, taste a little less than, be easy to by injury due to diet, dysfunction of the spleen in transportation, essence of water and grain can not be converted to marrow, leads on the contrary expectorant turbid, is above stored in lung, stagnation of phlegm is out of breath, lung can not be declared and be sent out and respectful falling, therefore cough with asthma, rale, indigestion and loss of appetite.The cough of suffering from a deficiency of the kidney is very rare in department of pediatrics, and the wet person of the spleen of take is at most, in method for the treatment of, is affected by the cold, wind heat person, and with lung qi dispersing cough-relieving, evacuation exopathogen is main; Productive cough due to phlegm-damp, with invigorating the spleen for dissipating phlegm, heat clearing and damp drying is main.
At present, for the treatment of infantile bronchitis, the general intravenous injection antibiotics that adopts being admitted to hospital is treated.Although adopt the intravenous injection antibiotics can very fast bringing down a fever, infant symptom be alleviated to a certain extent to some extent, and curative effect is unsatisfactory, and the symptom of especially coughing is difficult to take effect rapidly.And there are some hidden danger: the one, long-term injection of antibiotics can affect child's growth; The 2nd, easy recurrence; The 3rd, there is more side effect.
Publication number CN 102406748A(application number 201110371755.9) Chinese patent literature discloses a kind of Chinese medicine composition for the treatment of infantile bronchitis, and this Chinese medicine composition is to adopt the material medicine of following weight proportion to combine: Herba Ephedrae 3-9, Semen Armeniacae Amarum 5-15, Herba Schizonepetae 5-15, Radix Saposhnikoviae 5-15, Herba Menthae 3-9, Radix Angelicae Dahuricae 3-9, Radix Puerariae 5-15, Radix Glycyrrhizae 2-5, Cortex Mori 5-15, Herba Houttuyniae 5-15.Publication number CN 103919970A(application number 201410172505.6) Chinese patent literature discloses a kind of Chinese medicine preparation and preparation method for the treatment of infantile bronchitis, and the raw material of Chinese medicine preparation effective ingredient consists of: Artemisia absinihium L, Resina Ferulae, Lignum Viticis Quinatae, Rhizoma Dioscoreae Nipponicae, Radix Angelicae Pubescentis, Membrana Follicularis ovi, Bufo siccus, Herba Rorippae, Herba sambuci chinensis, Herba Lysionoti carnosae, Sabia schumanniana Diels, Folium Rhododendri Micranthi, Folium Alismatis, Rhizoma Paridis, Semen Caesalpiniae and Herba Eupatorii Lindleyani.Publication number CN 102793841A(application number 201210316446.6) Chinese patent literature discloses a kind of Chinese medicine composition for the treatment of infantile acute bronchitis, and this Chinese medicine composition is made by the Chinese medicine of following weight portion: Radix Crepidis Ligneae 9-11 part, Caulis Marsdeniae Tenacissimae 9-11 part, Radix Adenophorae Trachelioidis 8-10 part, Semen Sinapis Albae 5-7 part, Bulbus Fritillariae Thunbergii 5-7 part, Cortex Mori 8-10 part, Radix Adenophorae 6-8 part, Radix Platycodonis 6-8 part, Radix Glycyrrhizae 4-6 part.
In a word, Chinese medicine is being obtained good curative effect aspect treatment primary disease, but also there are some problems: at present, adopt the bronchitic Chinese medicine of Children Treated with Chinese Traditional Drugs more, large mainly with antitussive, eliminate the phlegm, pain relieving, the Chinese medicine of bringing down a fever be main, for now, simple employing treatment by Chinese herbs, exist that toleration is poor, children's is difficult for the deficiency of accepting, treatment time is long, the more important thing is that child's the head of a family is also not easy to adopt, and fears to affect adversely treatment opportunity.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that a kind of preparation method is simple, safe and reliable, instant effect, taking convenience, easily feeding, infantile bronchitis syrup with low cost and preparation method thereof.
Technical scheme of the present invention is:
Infantile bronchitis syrup, is prepared from by following bulk drugs, is weight portion: carbetapentane citrate 0.8-1.2 part, and ammonium chloride 6-9 part, Radix Berberidis Amurensis 45-60 part, Usnea 62-80 part (preferred, Usnea 65-75 part; Be more preferably 70 parts of Usneas), Radix Platycodonis 32-45 part, sodium benzoate 4-10 part, Radix Glycyrrhizae fluidextract 30-40 part, saccharide 280-360 part, surplus is water.
In preferred scheme, carbetapentane citrate 0.9-1.1 part, ammonium chloride 6.5-8.5 part, Radix Berberidis Amurensis 50-55 part, Usnea 65-75 part, Radix Platycodonis 38-42 part, sodium benzoate 5-8 part, Radix Glycyrrhizae fluidextract 35-38 part, saccharide 300-340 part, surplus is water.
Be more preferably, 1.0 parts of carbetapentane citrates, 7.0 parts of ammonium chloride, 52 parts of Radix Berberidis Amurensis, 68 parts of Usneas, 40 parts of Radix Platycodoniss, 6 parts of sodium benzoate, 37 parts of Radix Glycyrrhizae fluidextract, 330 parts of saccharides, surplus is water.
The preparation method of above-mentioned infantile bronchitis syrup, step is as follows:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 30%-85% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) be 1.6-2.4 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.4-9.0 with alkali.
(3) saccharide first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Preferably be in step (1) ethanol that is 40%-70% by mass concentration.
Preferably be in step (1), evaporation and concentration to volume (by milliliter) be crude drug in whole weight (by gram) 1.8-2.2 doubly.
Preferably be that, in step (2), alkali used is ammonia, potassium hydroxide or sodium hydroxide.
Preferably be in step (2), regulate pH=7.6-8.4.
Preferably be that, in step (3), saccharide is xylitol, crystal sugar, sucrose or maltose.
Be more preferably, in step (1), the ethanol that is 60% by mass concentration.
Be more preferably, evaporation and concentration to volume (by milliliter) is 2.0 times of crude drug in whole weight (by gram) in step (1).
Be more preferably, in step (2), regulate pH=8.0.
The raw materials used effect of the present invention is as follows:
Carbetapentane citrate: conventional its citrate is crystallinity or the graininess powder of white or off-white color; Odorless, bitter in the mouth.Pharmacological action: this product, to the selective inhibitory action of coughing centre, still has slight atropine-like effect and local anesthetic action, heavy dose of have spasmolysis to bronchial smooth muscle, therefore it has central and tip antitussive effect concurrently.Indication: be mainly used in dry cough that upper respiratory tract infection causes and pertussis etc.
Ammonium chloride: be clear crystal or white crystalline powder; Odorless, salty in the mouth, cool; Have draw moist.Due to this product phlegm-dispelling functions a little less than, normal be made into compound preparation use with other eliminating phlegm and stopping cough medicines.Pharmacological action: the vagus nerve of the oral rear stimulation gastric mucosa of this product, cause slight feeling sick, cause to reflexive that trachea and bronchus glandular secretion increases, sputum dilution.Some drugs absorbed into serum is got rid of by respiratory tract, because moisture is taken in the osmotic pressure effect of salt out of, makes sputum dilution, is easy to get rid of.Indication: be applicable to dry cough and glutinous expectorant is difficult for expectoration person.
Radix Berberidis Amurensis: another name: sub-bark of a cork tree, Catunaregam spinosa (Thunb.) Tirveng., Radix Berberidis, the yellow thorn of mountain.Nature and flavor: hardship, Great Cold.Gui Jing: return lung, liver, spleen channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.Cure mainly: diarrhea due to damp-heat, dysentery, aphtha of the mouth and tongue, pharyngalgia sore throat, conjunctival congestion and swelling pain, carbuncle furuncle.
Usnea: nature and flavor: sweet, flat.Gui Jing: GUIXIN, kidney, lung meridian.Effect: heat-clearing and toxic substances removing, relieving cough and resolving phlegm.Cure mainly: for pulmonary tuberculosis (sodium salt of multiplex usnic acid), chronic bronchitis; Traumatic infection is controlled in external, and postoperative incision infects, suppurative otitis media, furuncle, tuberculous lymphadenitis, mastitis, burn, cervical erosion, trichomonas vaginitis.
Radix Platycodonis: nature and flavor: bitter, pungent, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Sodium benzoate: another name: sodium benzoate is white crystalline powder or granule; Odorless, taste micro-sweet be with salty.Pharmacological action: there is the effect of anti-bacteria and conk.Indication: for the anticorrosive mildewproof of oral liquid preparation, be especially not suitable for the anticorrosion of benzoinated neutrality or alkalescence medicament and food.
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Radix Glycyrrhizae fluidextract is the fluid extract through being processed into by Radix Glycyrrhizae extractum.Radix Glycyrrhizae fluidextract is liquid brown or russet; Taste is sweet, summary is bitter, puckery.Effect: obtundent, normal and preventing phlegm from forming and stopping coughing medicine compatibility application, can alleviate the stimulation to pharyngeal mucosa, and has the gastrointestinal smooth muscular spasm of alleviation and the effect of desoxycortone sample.Cure mainly: for bronchitis, pharyngolaryngitis, bronchial asthma, chronic adrenocortical hypofunction.
The present invention compared with prior art, has the advantages such as curative effect is fast, convenient oral, for infantile bronchitis provides a kind of preparation method of desirable syrup.In addition, excellent results of the present invention also shows:
1, this product determined curative effect, safe and reliable, has no side effect;
2, preparation method simple, be easy to production operation;
3, storage is convenient, convenient transportation;
4, medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden;
5, taste is fragrant and sweet, and dose is little, therefore children's is acceptant.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not limited to this.
embodiment 1an infantile bronchitis syrup, take weight portion (every part is 20g), and its component is: 0.8 part of carbetapentane citrate, and 6 parts of ammonium chloride, 45 parts of Radix Berberidis Amurensis, 62 parts of Usneas, 32 parts of Radix Platycodoniss, 4 parts of sodium benzoate, 30 parts of Radix Glycyrrhizae fluidextract, 280 parts of xylitol, surplus is water.
The preparation method of above-mentioned infantile bronchitis syrup, step is as follows:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 30% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 1.6 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.4 with ammonia.
(3) xylitol first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
The instructions of taking of syrup of the present invention: oral, one-year-old to two years old one time 3～4 milliliters, two years old to five years old one time 4～6 milliliters, six years old to 14 years old one time 6～12 milliliters, 3～4 times on the one.
embodiment 2the preparation of infantile bronchitis syrup (every part is 50g): 1.2 parts of carbetapentane citrates, 9 parts of ammonium chloride, 60 parts of Radix Berberidis Amurensis, 80 parts of Usneas, 45 parts of Radix Platycodoniss, 10 parts of sodium benzoate, 40 parts of Radix Glycyrrhizae fluidextract, 360 parts, crystal sugar, surplus is water.
The preparation method of above-mentioned infantile bronchitis syrup, step is as follows:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 85% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.4 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=9.0 with sodium hydroxide.
(3) crystal sugar first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Model case: high XX, man, 3 years old.Infant heating, cough asthma.Check: 38 ℃ of body temperature, auscultation two lungs are covered with rale sound, nasal obstruction watery nasal discharge, mouth is not thirsty, lack of appetite, god is tired, pale tongue with white fur, floating and tense pulse.Card belongs to cold fluid-retention cough with asthma type infantile bronchitis.Give infusion penicillin Drug therapy, unsatisfactory curative effect.
Take the present embodiment 2 gained infantile bronchitis syrups, each 4 milliliters, every day 3 times.Take after 2 days, body temperature is normal, and cough alleviates, continue to take 4 days, and sick child's disappearance of coughing, body temperature is normal, and all diseases are removed, recovery from illness.
embodiment 3the preparation of infantile bronchitis syrup (every part is 10g): 0.9 part of carbetapentane citrate, 6.5 parts of ammonium chloride, 50 parts of Radix Berberidis Amurensis, 65 parts of Usneas, 38 parts of Radix Platycodoniss, 5 parts of sodium benzoate, 35 parts of Radix Glycyrrhizae fluidextract, 300 parts of sucrose, surplus is water.
The preparation method of above-mentioned infantile bronchitis syrup, step is as follows:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 40% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 1.8 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.6 with potassium hydroxide.
(3) sucrose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Model case: Xu XX, female, 5 years old.Infant cough is violent, and expectorant is more sticky, is difficult to bring up, concurrent hot-fluid tears, celostomia.Check: 38.2 ℃ of body temperature, swallow red, ° enlargement of tonsil I, two pulmonary respiration sounds are thick, a small amount of rhonchi of base of lung portion audible and rale sound.Red tongue, the micro-Huang of tongue are greasy, floating and rapid pulse.Card belongs to lung-heat cough with asthma type infantile bronchitis.With crossing multiple Drug therapy, poor effect is invalid.
Take the present embodiment 3 gained infantile bronchitis syrups, each 6 milliliters, every day 3 times.Take 3 days, heat is moved back, and symptom obviously alleviates.Take 6 days, not enlargement of tonsil, two pulmonary respiration sounds are clear, transference cure.
embodiment 4the preparation of infantile bronchitis syrup (every part is 50g): 1.1 parts of carbetapentane citrates, 8.5 parts of ammonium chloride, 55 parts of Radix Berberidis Amurensis, 75 parts of Usneas, 42 parts of Radix Platycodoniss, 8 parts of sodium benzoate, 38 parts of Radix Glycyrrhizae fluidextract, 340 parts of maltose, surplus is water.
The preparation method of above-mentioned infantile bronchitis syrup, step is as follows:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 70% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.2 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=8.4 with sodium hydroxide.
(3) maltose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Model case: woods XX, female, 6 years old.Be admitted to hospital and within first 20 days, occur at local hospital, checking cough, heating that body temperature is normal, but still have cough, in larynx, have expectorant, cough in nearly 4 days increases the weight of to go to a doctor.Human health screening: 36.3 ℃ of body temperature, regular respiratory, two lungs are heard and rale sound and the sound of stridulating, and cardiac auscultation is normal, and abdomen is soft, and liver spleen is little, and routine blood test is normal, chest films showed bronchitis.After being admitted to hospital, give antibiotic intravenous drip conventional therapy, cough has no and alleviates.
Take the present embodiment 4 gained infantile bronchitis syrups, each 6 milliliters, every day 4 times.Take 2 days, cough alleviates, and continues to take after 4 days, and cough disappears, and rabat check shows that cardiopulmonary are normal, recovery from illness.
embodiment 5the preparation of infantile bronchitis syrup (every part is 100g): 1.0 parts of carbetapentane citrates, 7.0 parts of ammonium chloride, 52 parts of Radix Berberidis Amurensis, 68 parts of Usneas, 40 parts of Radix Platycodoniss, 6 parts of sodium benzoate, 37 parts of Radix Glycyrrhizae fluidextract, 330 parts of sucrose, surplus is water.
The preparation method of above-mentioned infantile bronchitis syrup, step is as follows:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 60% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.0 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=8.0 with ammonia.
(3) sucrose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
test example 1the clinical practice of embodiment 5 gained infantile bronchitis syrup: in April, 2010-2013 year February, screen 152 routine patients in 6 hospitals, women's 88 examples wherein, male's 64 examples, oldest 9 years old, minimal ages 1 years old, 3.5 years old mean age.Test 2 weeks before, this crowd is carried out to Continuous Observation, record symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (xiao'er ganmao granules, children's's oral liquid for clearing away lung-heat, XIAOER ZHIKE TANGJIANG, declare clearly the conventional medicines such as pectoral syrup).Using method is: oral, one-year-old to two years old one time 3～4 milliliters, two years old to five years old one time 4～6 milliliters, six years old to 14 years old one time 6～12 milliliters, 3～4 times on the one.The criterion of curative effect situation: recovery from illness: patient respiratory is steady, asthma, cough transference cure, pulmonary's moist rale and wheezing sound disappear; Effective: patient's asthma, cough all have certain alleviation, and pulmonary's moist rale and wheezing sound reduce; Invalid: patient's asthma, cough have no alleviation, and physical signs of lung has no change, a large amount of moist rales of pulmonary's audible and wheezing sound.Total effective rate=(recovery from illness+effective)/total number of cases * 100%.Result is as shown in table 1.
Table 1 experimental group and the comparison of matched group curative effect
During taking, symptom and physical signs of lung thereof change as shown in table 2.
Table 2:
Select in the experimental group of infantile bronchitis syrup of the present invention recovery from illness 68 examples, effective 6 examples, invalid 2 examples, cure rate 89.47%, total effective rate 97.37%, and 52 examples of fully recovering in matched group, effective 12 examples, invalid 12 examples, cure rate 68.42%, total effective rate 84.21%.Above result demonstration, the cure rate of experimental group and total effective rate are apparently higher than matched group.
The present invention selects carbetapentane citrate, Radix Berberidis Amurensis, Usnea, Radix Platycodonis, Radix Glycyrrhizae fluidextract etc. to carry out compatibility, makes after these drug regimens to produce synergism, can more effectively treat infantile bronchitis.In side, carbetapentane citrate has central and tip antitussive effect concurrently; Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus; Radix Berberidis Amurensis heat clearing and damp drying, eliminating fire and detoxication; Usnea heat-clearing and toxic substances removing, relieving cough and resolving phlegm.The present invention meets Chinese medical theory, has the effect of eliminating phlegm and relieving asthma, heat-clearing and toxic substances removing.Product good effect of the present invention, instant effect, taking convenience, have no side effect, infantile bronchitis is had to good therapeutic effect.Take 2 days, 53% pediatric patient asthma, cough symptom are improved; Take 4 days, 76% pediatric patient physical signs of lung improves; Take 7 days, 96% pediatric patient is breathed steadily, and asthma, cough symptom all disappear, and pulmonary's moist rale and wheezing sound disappear.In experimental group, take 7 days, effective percentage can reach 96%, and matched group is only 76%.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (10)
1. an infantile bronchitis syrup, it is characterized in that, by following raw materials according, be prepared from, be weight portion: carbetapentane citrate 0.8-1.2 part, ammonium chloride 6-9 part, Radix Berberidis Amurensis 45-60 part, Usnea 62-80 part, Radix Platycodonis 32-45 part, sodium benzoate 4-10 part, Radix Glycyrrhizae fluidextract 30-40 part, saccharide 280-360 part, surplus is water.
2. infantile bronchitis syrup as claimed in claim 1, is characterized in that, carbetapentane citrate 0.9-1.1 part, ammonium chloride 6.5-8.5 part, Radix Berberidis Amurensis 50-55 part, Usnea 65-75 part, Radix Platycodonis 38-42 part, sodium benzoate 5-8 part, Radix Glycyrrhizae fluidextract 35-38 part, saccharide 300-340 part, surplus is water.
3. infantile bronchitis syrup as claimed in claim 1, is characterized in that, 1.0 parts of carbetapentane citrates, and 7.0 parts of ammonium chloride, 52 parts of Radix Berberidis Amurensis, 68 parts of Usneas, 40 parts of Radix Platycodoniss, 6 parts of sodium benzoate, 37 parts of Radix Glycyrrhizae fluidextract, 330 parts of saccharides (sucrose), surplus is water.
4. the preparation method of the infantile bronchitis syrup as described in as arbitrary in claim 1～3, is characterized in that, comprises the following steps:
(1) Radix Berberidis Amurensis, Usnea, Radix Platycodonis are pulverized together rough, the ethanol solvent that is 30%-85% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) be 1.6-2.4 times of crude drug in whole weight (by gram);
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.4-9.0 with alkali;
(3) saccharide first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again;
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
5. preparation method as claimed in claim 4, is characterized in that, the mass concentration of step (1) ethanol used is that 40%-70%(is preferred, and the mass concentration of ethanol is 60%).
6. preparation method as claimed in claim 4, is characterized in that, step (1) reclaims ethanol, and evaporation and concentration to volume is 1.8-2.2 times (preferred, evaporation and concentration to volume is 2.0 times of crude drug in whole weight) of crude drug in whole weight.
7. preparation method as claimed in claim 4, is characterized in that, in step (2), alkali used is ammonia, sodium hydroxide or potassium hydroxide.
8. preparation method as claimed in claim 4, is characterized in that, regulates pH=7.6-8.4(preferred in step (2), regulates pH=8.0).
9. preparation method as claimed in claim 4, is characterized in that, the saccharide in step (3) is selected from xylitol, crystal sugar, sucrose or maltose.
10. the application of the infantile bronchitis syrup as described in as arbitrary in claim 1～3 when treatment infantile bronchitis.
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| CN104434789A (en) * | 2014-12-27 | 2015-03-25 | 昆明振华制药厂有限公司 | Preparing method of citron pentoxyverine syrup |
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| CN1650889A (en) * | 2004-11-29 | 2005-08-10 | 俞锋 | Child cough stopping sgrup and its preparation method |
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