CN104984160A

CN104984160A - Medicinal preparation for treating eczema

Info

Publication number: CN104984160A
Application number: CN201510366153.2A
Authority: CN
Inventors: 徐国华
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-28
Filing date: 2015-06-28
Publication date: 2015-10-21

Abstract

The invention belongs to the field of traditional Chinese medicinal preparations, and particularly provides a medicinal preparation for treating eczema which is prepared from the following raw materials in parts by weight: 20 parts of periploca calophylla, 18 parts of cyrtomium caryotideum, 10 parts of cortex moutan, 10 parts of radix paeoniae rubra, 10 parts of astragalus membranaceus, 10 parts of capejasmine, 10 parts of prunella vulgaris, 10 parts of magnolia officinalis, 10 parts of atractylodes lancea, 10 parts of radix sophorae flavescentis, 10 parts of phellodendron amurense, 10 parts of angelica dahurica, 30 parts of coix seeds, 10 parts of dried zaocys dhumnades, 8 parts of periostracum cicada, 15 parts of broom cypress fruit, 10 parts of folium artemisiae argyi, 10 parts of rhizoma acori graminei and 3 parts of radix glycyrrhizae. The medicinal preparation provided by the invention can treat eczema.

Description

A kind of pharmaceutical preparation being used for the treatment of eczema

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of eczema and its preparation method and application.

Background technology

Eczema is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor.Divide acute, subacute, chronic three phases.Acute stage, tool oozed out tendency, and chronic phase then infiltrates, plumpness.Some patient directly translates into chronic eczema.Skin lesion has the features such as pleomorphism, symmetry, pruritus and easy recurrent exerbation.For this reason, be bursting to and develop the needs that more medicines for the treatment of eczema safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of eczema.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of eczema, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: blue or green mabi 20 parts, cyrtomium caryotideumPresl 18 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Astragali 10 parts, Fructus Gardeniae 10 parts, Spica Prunellae 10 parts, Cortex Magnoliae Officinalis 10 parts, Rhizoma Atractylodis 10 parts, Radix Sophorae Flavescentis 10 parts, Cortex Phellodendri 10 parts, the Radix Angelicae Dahuricae 10 parts, Semen Coicis 30 parts, ophidia 10 parts, Periostracum Cicadae 8 parts, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 10 parts, Rhizoma Acori Graminei 10 parts, 3 parts, Radix Glycyrrhizae.

The described pharmaceutical preparation being used for the treatment of eczema, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of eczema, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of pharmaceutical preparation in preparation treatment eczema medicine being used for the treatment of eczema.

The blue or green mabi of above-mentioned Chinese medicine is asclepiadaceae Periploca Plants U.S. leaf P. sepium Bunge Periploca calophylla (Wight) Falc., is used as medicine with stem, expelling wind and cold, cold expelling of invigorating blood circulation.For rheumatic numbness, lumbago, traumatic injury, menoxenia.

Cyrtomium caryotideumPresl is Dryopteridaceae Cyrtomium plant, latin name: Cyrtomium caryotideum (Wall.ex Hook.et Grev.) Presl, heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, diuretic.For scrofula, furunculosis furuncle and phyma, flu, metrorrhagia, traumatic injury, edema.The present invention is with all herbal medicine.All the other are pharmacopeia kind.

Beneficial effect: the blue or green mabi of the present invention, cyrtomium caryotideumPresl, Cortex Moutan, Radix Paeoniae Rubra, the Radix Astragali, Fructus Gardeniae, Spica Prunellae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, Radix Sophorae Flavescentis, Cortex Phellodendri, the Radix Angelicae Dahuricae, Semen Coicis, ophidia, Periostracum Cicadae, the Fructus Kochiae, Folium Artemisiae Argyi, Rhizoma Acori Graminei, Radix Glycyrrhizae, dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, treatment eczema successful.The present invention actively can prevent and treat generation and the development of eczema effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get blue or green mabi 20g, cyrtomium caryotideumPresl 18g, Cortex Moutan 10g, Radix Paeoniae Rubra 10g, Radix Astragali 10g, Fructus Gardeniae 10g, Spica Prunellae 10g, Cortex Magnoliae Officinalis 10g, Rhizoma Atractylodis 10g, Radix Sophorae Flavescentis 10g, Cortex Phellodendri 10g, Radix Angelicae Dahuricae 10g, Semen Coicis 30g, ophidia 10g, Periostracum Cicadae 8g, Fructus Kochiae 15g, Folium Artemisiae Argyi 10g, Rhizoma Acori Graminei 10g, Radix Glycyrrhizae 3g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get blue or green mabi 20g, cyrtomium caryotideumPresl 18g, Cortex Moutan 10g, Radix Paeoniae Rubra 10g, Radix Astragali 10g, Fructus Gardeniae 10g, Spica Prunellae 10g, Cortex Magnoliae Officinalis 10g, Rhizoma Atractylodis 10g, Radix Sophorae Flavescentis 10g, Cortex Phellodendri 10g, Radix Angelicae Dahuricae 10g, Semen Coicis 30g, ophidia 10g, Periostracum Cicadae 8g, Fructus Kochiae 15g, Folium Artemisiae Argyi 10g, Rhizoma Acori Graminei 10g, Radix Glycyrrhizae 3g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get blue or green mabi 20g, cyrtomium caryotideumPresl 18g, Cortex Moutan 10g, Radix Paeoniae Rubra 10g, Radix Astragali 10g, Fructus Gardeniae 10g, Spica Prunellae 10g, Cortex Magnoliae Officinalis 10g, Rhizoma Atractylodis 10g, Radix Sophorae Flavescentis 10g, Cortex Phellodendri 10g, Radix Angelicae Dahuricae 10g, Semen Coicis 30g, ophidia 10g, Periostracum Cicadae 8g, Fructus Kochiae 15g, Folium Artemisiae Argyi 10g, Rhizoma Acori Graminei 10g, Radix Glycyrrhizae 3g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment eczema of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation eczema case 70 example, the shortest person of the course of disease 1 year, and most elder reaches 2 years, average 1.5 years.

4.2 diagnostic criterias: acute eczema (1) acute onset, skin lesion is made up of erythema, pimple, vesicle.Collection bunch slabbing, often causing erosion because scratching, oozing out, form a scab and the change such as suppuration, blur margin, is often symmetric.(2) play is itched.2, subacute eczema: after acute pathological changes inflammation alleviates, sepage reduces, the course of disease is delayed, skin lesion, based on pimple, squama and incrustation, only has minority papulovesicle and rotten to the corn or have mild infiltration.3, chronic eczema (1) can cause from acute eczema recurrent exerbation or namely in chronic.(2) after being apt to occur in face, ear, the position such as Zhou, popliteal nest, shank, pudendum and anus, companion's play is itched.(3) skin lesion comparatively limits to, and significantly, boundary is clear, has pigmentation more in plump infiltration.(4) course of disease is chronic, often has acute attack.4, oneself sensitivity eczema (1) premorbid, often has eczema to exist in skin portion.(2) after 7 ~ 10 days, there is suddenly majority and be dispersed in pimple in whole body, and papulovesicle and phlysis are symmetrical, and have isomorphic response.(3), after primary lesion takes a turn for the better, whole body skin lesion also naturally alleviates, disappears.(4) acute pruritus.5, infectious eczematoid dermatitis (1) has constitutional suppuration focus near site of pathological change.(2) skin lesion is centered by suppuration focus, to surrounding expansion, shows as erythema, vesicle, pustule, erosion, incrustation etc.Progress is fast, asymmetric, the normal distribution that becomes band along direction of scratching.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: clinical recovery: eczema disappears, and simultaneous phenomenon disappears, and follows up a case by regular visits to 1 month without recurrence after treatment terminates; Take a turn for the better: symptom, sign alleviate or improve.Invalid: symptom, sign are all without improvement.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	35	12	19	4	88.6
Blank group	35	2	2	31	11.4

Visible, the medicine that the present invention obtains can safe and effective treatment eczema, and have no side effect.

Claims

1. one kind is used for the treatment of the pharmaceutical preparation of eczema, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: blue or green mabi 20 parts, cyrtomium caryotideumPresl 18 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Astragali 10 parts, Fructus Gardeniae 10 parts, Spica Prunellae 10 parts, Cortex Magnoliae Officinalis 10 parts, Rhizoma Atractylodis 10 parts, Radix Sophorae Flavescentis 10 parts, Cortex Phellodendri 10 parts, the Radix Angelicae Dahuricae 10 parts, Semen Coicis 30 parts, ophidia 10 parts, Periostracum Cicadae 8 parts, the Fructus Kochiae 15 parts, Folium Artemisiae Argyi 10 parts, Rhizoma Acori Graminei 10 parts, 3 parts, Radix Glycyrrhizae.

2. be used for the treatment of the pharmaceutical preparation of eczema as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the pharmaceutical preparation of eczema as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of pharmaceutical preparation in treatment eczema medicine of eczema according to claim 1.