CN104721282A - Traditional Chinese composition used for treating hepatic fibrosis - Google Patents
Traditional Chinese composition used for treating hepatic fibrosis Download PDFInfo
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- CN104721282A CN104721282A CN201510175718.9A CN201510175718A CN104721282A CN 104721282 A CN104721282 A CN 104721282A CN 201510175718 A CN201510175718 A CN 201510175718A CN 104721282 A CN104721282 A CN 104721282A
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Abstract
The invention provides traditional Chinese composition used for treating hepatic fibrosis. The traditional Chinese composition is prepared by 12 parts of bryophyllum, 10 parts of stellaria vestita and 6 parts of capitate knotweed herb. Via pharmaceutical experiments, the traditional Chinese composition is used for treating hepatic fibrosis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of hepatic fibrosis and its preparation method and application.
Background technology
Hepatic fibrosis is commonly called as liver cirrhosis, refers to connective tissue paraplasm in liver caused by various virulence factor, causes the pathological process of diffusivity extracellular matrix excessive deposition in liver.It is not an independently disease, and many chronic hepatic diseases all can cause hepatic fibrosis.In China, how by drinking, viral hepatitis, bad life habits and bring out hepatic fibrosis, possess case load every year more than 3,000 ten thousand people.Comparatively common clinically, because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of hepatic fibrosis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of hepatic fibrosis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of hepatic fibrosis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Bryophylli Pinnati 12 parts, mountain valley with clumps of trees and bamboo aunt grass 10 parts, Herba Polygoni Capitati 6 parts.
The described Chinese medicine composition being used for the treatment of hepatic fibrosis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of hepatic fibrosis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of Chinese medicine composition in preparation treatment hepatic fibrosis medicines being used for the treatment of hepatic fibrosis.
Herba Bryophylli Pinnati is Crassulaceae Herba Bryophylli Pinnati platymiscium Herba Bryophylli Pinnati Kalanchoe pinnatum (L.) Pers., with all herbal medicine.The whole year can adopt, many using fresh herbs.Removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain, removing toxic substances and promoting tissue regeneration.Carbuncle pyogenic infections from tumour or sore is controlled in external, mastitis, erysipelas, panaris, traumatic hemorrhage, traumatic injury, fracture, burn and scald, otitis media.Mountain valley with clumps of trees and bamboo aunt grass (formal name used at school: Stellariavestita) is the plant of Caryophyllaceae Stellaria.Herb hyoscine, can relaxing muscles and tendons to promote blood circulation.Herba Polygoni Capitati is the herb of polygonaceae plant Herba Polygoni Capitati.Classification system Polygonum capitatum Buch detoxifies, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Control dysentery, pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.The present invention is with all herbal medicine.。
Beneficial effect: the present invention treats hepatic fibrosis successful.The present invention actively can prevent and treat generation and the development of hepatic fibrosis effectively, and this is for improving existence and the quality of life of broad masses, protecting the health of broad masses, and then raising productivity, significant and higher practical value.Because primary disease sickness rate is high, estimate, once marketing application, good Social benefit and economic benefit will be produced.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Bryophylli Pinnati 12g, mountain valley with clumps of trees and bamboo aunt grass 10g, Herba Polygoni Capitati 6g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Bryophylli Pinnati 12g, mountain valley with clumps of trees and bamboo aunt grass 10g, Herba Polygoni Capitati 6g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Bryophylli Pinnati 12g, mountain valley with clumps of trees and bamboo aunt grass 10g, Herba Polygoni Capitati 6g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, Chinese medicine composition of the present invention is studied rat liver fibrosis clinical pharmacology
4.1 medicines: prepare by the preparation method of granule in above-described embodiment.
4.2 experimentations: get rat (Nanjing Medical University's Experimental Animal Center provides) 60, be divided into Normal group (distilled water 20ml/kg), carbon tetrachloride model control group (distilled water 20ml/kg), carbon tetrachloride+bifendate matched group (0.1g/kg) at random, carbon tetrachloride+senior middle school of the present invention low dose group (10,5,2.5g/kg).Every day gastric infusion once, continuous 45 days, except Normal group, each animal gavage carbon tetrachloride 0.3ml/100g (40% soybean oil solution) every 3 days, initial dose 0.5ml/100g.In last administration after 24 hours, sacrificed by decapitation animal, gets hepatic tissue and measures hydroxyproline regulating liver-QI total lipid content, the results are shown in Table 1, table 2.Do hepatic tissue pathology section, after dyeing, the fibrosis of basis of microscopic observation liver, compares with model group simultaneously.
Table 1 is on the impact of hydroxyproline content in rat liver tissue
| Group | Hydroxyproline content (mg/100g) |
| Normal group | 0.78±0.12 |
| Carbon tetrachloride model control group | 2.13±0.30 |
| Bifendate matched group | 1.38±0.14 |
| High dose of the present invention | 1.45±0.11 |
| Dosage in the present invention | 1.67±0.18 |
| Low dosage of the present invention | 1.89±0.15 |
Table 2 is on the impact of total lipid content in rat liver tissue
| Group | Hydroxyproline content (mg/100g) |
| Normal group | 30.31±5.43 |
| Carbon tetrachloride model control group | 42.76±6.13 |
| Bifendate matched group | 29.49±3.62 |
| High dose of the present invention | 25.78±3.31 |
| Dosage in the present invention | 29.38±4.32 |
| Low dosage of the present invention | 36.21±5.76 |
Table 1 and table 2 show, bifendate group and high dose group of the present invention all significantly can reduce hydroxyproline content in hepatic tissue and total lipid content, and middle dosage group is taken second place.Check pathological section result shows, and the hepatic tissue fibroplasia of bifendate group, high, the middle dosage group of the present invention obviously reduces, and has no severe fibrosis and occurs; The degree of hepatic fibrosis of high dose group of the present invention comparatively in dosage group light, and middle dosage group comparatively low dose group is light, show dose-effect relation.
Claims (4)
1. be used for the treatment of a Chinese medicine composition for hepatic fibrosis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Bryophylli Pinnati 12 parts, mountain valley with clumps of trees and bamboo aunt grass 10 parts, Herba Polygoni Capitati 6 parts.
2. be used for the treatment of the Chinese medicine composition of hepatic fibrosis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of hepatic fibrosis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in treatment hepatic fibrosis medicines of hepatic fibrosis according to claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984160A (en) * | 2015-06-28 | 2015-10-21 | 徐国华 | Medicinal preparation for treating eczema |
| CN105125698A (en) * | 2015-10-09 | 2015-12-09 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutical preparation for treating hepatic fibrosis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784248A (en) * | 2012-09-03 | 2012-11-21 | 赵全成 | Chinese medicine composition for preventing and treating alcoholic liver injury |
| CN104324259A (en) * | 2014-10-30 | 2015-02-04 | 张立 | Pharmaceutical composition for treating hepatitis B and preparation method of pharmaceutical composition |
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2015
- 2015-04-14 CN CN201510175718.9A patent/CN104721282A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784248A (en) * | 2012-09-03 | 2012-11-21 | 赵全成 | Chinese medicine composition for preventing and treating alcoholic liver injury |
| CN104324259A (en) * | 2014-10-30 | 2015-02-04 | 张立 | Pharmaceutical composition for treating hepatitis B and preparation method of pharmaceutical composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984160A (en) * | 2015-06-28 | 2015-10-21 | 徐国华 | Medicinal preparation for treating eczema |
| CN105125698A (en) * | 2015-10-09 | 2015-12-09 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutical preparation for treating hepatic fibrosis |
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Application publication date: 20150624 |