CN107019740A - It is a kind of to be used to prevent and treat Chinese medicine composition of virus B hepatitis and preparation method thereof - Google Patents

It is a kind of to be used to prevent and treat Chinese medicine composition of virus B hepatitis and preparation method thereof Download PDF

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CN107019740A
CN107019740A CN201610065082.7A CN201610065082A CN107019740A CN 107019740 A CN107019740 A CN 107019740A CN 201610065082 A CN201610065082 A CN 201610065082A CN 107019740 A CN107019740 A CN 107019740A
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chinese medicine
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左俊岭
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Abstract

The invention belongs to technical field of traditional Chinese medicines, specifically, it is related to a kind of for preventing and treating Chinese medicine composition of virus B hepatitis and preparation method thereof.The Chinese medicine composition of the present invention for being used to prevent and treat virus B hepatitis includes following Chinese herb：The parts by weight of Moringa 2~200, the parts by weight of the fruit of glossy privet 3~50, the parts by weight of the fruit of Chinese magnoliavine 1~50, the parts by weight of the Radix Astragali 3~100, the parts by weight of ganoderma lucidum 2~50, the parts by weight of Radix Isatidis 1~50, the parts by weight of roxburgh peristrophe herb 2~100, the parts by weight of beautiful millettia root 1~100, the parts by weight of hypericum japonicum 1~100, the parts by weight of strophanthus divaricatus 1~100.Chinese medicine composition of the invention is cheap, safe and effective, curative effect is reliable, can improve patient's immune level, reduces hepatitis B serum carrying capacity, improves liver function, improves life in patients.

Description

It is a kind of to be used to prevent and treat Chinese medicine composition of virus B hepatitis and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, specifically, it is related to a kind of Chinese traditional medicine composition for being used to prevent and treat virus B hepatitis Thing and preparation method thereof.
Background technology
Virus B hepatitis (abbreviation hepatitis B) be caused by the hepatitis type B virus (hepatitis B, HBV), with Whole body sexually transmitted disease based on liver damage.HBV infection is in worldwide prevalence, according to World Health Organization, the whole world about 20 Hundred million people once infected HBV, wherein 3.5 hundred million people are Patients with Chronic HBV Infection, 1,000,000 people are there are about every year and die from HBV senses Hepatic failure, hepatic sclerosis and primary hepatoma caused by dye.Modern medicine essential therapeutic arsenals include antiviral, immune adjust Section, the improvement treatment such as liver function and anti-hepatic fibrosis.Wherein antiviral therapy plays key in control hepatitis B course of disease progress Effect.Current clinical applicable antiviral drugs mainly has interferon and nucleoside analog.It is secondary but interferon adaptive surface is narrow Effect is obvious, and late result is undesirable, expensive.Nucleoside analog is easy to produce virus variation etc., and these medicines are only Suppressing virus replication but thoroughly removing can be difficult to, and recurrence rate is higher.It is restricted its clinical practice.Therefore from China Seeking to prevent and treat the medicine of hepatitis B in abundant Chinese herbal medicine resource has great social effect and economic benefit.Hepatitis B Belong to the categories such as traditional Chinese medicine " hypochondriac pain ", " jaundice " " damp-warm syndrome ".The positive unsaturated vapor of this cause of disease body, causes epidemic disease caused by damp-heat pathogen poison invasion and attack, by gas Enter blood, taste hepato-biliary function imbalance, blood vessels are occurred becoming silted up in hypochondriac pain, bile, overflow for jaundice by disease, stagnation in liver meridian.This disease Principle of reatment is supplementing qi and nourishing yin, based on removing toxic substances righting.Chinese medicine is protecting liver cell, is adjusting immune, anti-hepatic fibrosis, and then Suppress and kill by comprehensive function to show its superiority in terms of virus.According to the traditional Chinese medical science occurrence regularity of hepatitis B, knot The pharmacological research achievement of modern Chinese herbal medicine is closed, research and development one kind can adjust raising patient's immune state, hepatitis B is removed automatically, It is simultaneously quick to repair the generation that hepatic injury blocks liver fibrosis, so as to prevent and treat the Chinese medicine of hepatitis B with traditional Chinese medical science Fuzheng Jiedu theory Compound preparation, has positive effect for the preventing and treating of hepatitis B.
CN1969957A discloses a kind of pharmaceutical composition for hepatitis and preparation and its system containing the pharmaceutical composition Preparation Method and purposes, the composition that the bulk drug of its contained composition and effectiveness is made is kuh-seng, the fruit of Chinese magnoliavine and the Radix Astragali, or is kuh-seng Extract, Schisandra chinens P.E and Astragalus Root P.E.Its weight proportion scope is：4-64 parts of kuh-seng, 0.5-20 parts of the fruit of Chinese magnoliavine, 0.5-20 parts of the Radix Astragali, or be 120-1920 parts of shrubby sophora extract, 15-600 parts of Schisandra chinens P.E, astragalus polyose 6-240 Part, or be 120-1920 parts of shrubby sophora extract, 15-600 parts of Schisandra chinens P.E, 6-240 parts of astragalus root total saponin.The medicine Compositions can be made it is any clinically or pharmaceutically acceptable formulation, preferably oral formulations or injection.The medicine Compositions have antihepatitic activity, available for the medicine for preparing various types of hepatitis such as treatment hepatitis A, hepatitis B, hepatitis. But the pharmaceutical composition curative effect is not notable enough.
The present inventor is through further investigation, on the basis of certain contribution of the Chinese herbal medicine certainly in treatment hepatopathy, by clinic sieve Choosing, principle is designed as with traditional Chinese medical science monarch prescription, pharmacological effect, and take into full account the effective active composition of decocting for Chinese herbal medicine Dissolution is than there is provided a kind of Chinese medicine composition for being used to prevent and treat hepatitis B.
The content of the invention
The primary and foremost purpose of the present invention is a kind of Chinese medicine composition for being used to prevent and treat hepatitis B of offer, and the Chinese medicine composition curative effect shows Write, safe without toxic side effect.
The second object of the present invention is to provide this for the preparation method for the Chinese medicine composition for preventing and treating hepatitis B, and this method is simple It is easy.
To realize the first object of the present invention, the present invention is adopted the following technical scheme that：
A kind of Chinese medicine composition for being used to prevent and treat virus B hepatitis, wherein, it is former that described Chinese medicine composition includes following Chinese medicine Material：The parts by weight of Moringa 2~200, the parts by weight of the fruit of glossy privet 3~50, the parts by weight of the fruit of Chinese magnoliavine 1~50, the weight of the Radix Astragali 3~100 Part, the parts by weight of ganoderma lucidum 2~50, the parts by weight of Radix Isatidis 1~50, the parts by weight of roxburgh peristrophe herb 2~100, the weight of beautiful millettia root 1~100 Part, the parts by weight of hypericum japonicum 1~100, the parts by weight of strophanthus divaricatus 1~100；
It is preferred that, described Chinese medicine composition includes following Chinese herb：The parts by weight of Moringa 2~100, the weight of the fruit of glossy privet 3~25 Part, the parts by weight of the fruit of Chinese magnoliavine 1~25, the parts by weight of the Radix Astragali 3~50, the parts by weight of ganoderma lucidum 2~25, the parts by weight of Radix Isatidis 1~25, The parts by weight of roxburgh peristrophe herb 2~50, the parts by weight of beautiful millettia root 1~50, the parts by weight of hypericum japonicum 1~50, the parts by weight of strophanthus divaricatus 1~50；
It is further preferred that described Chinese medicine composition includes following Chinese herb：The parts by weight of Moringa 2, the parts by weight of the fruit of glossy privet 3, five The parts by weight of taste 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the parts by weight of roxburgh peristrophe herb 2, beautiful millettia root 1 parts by weight, the parts by weight of hypericum japonicum 1, the parts by weight of strophanthus divaricatus 1.
Further, described Chinese medicine composition also includes following Chinese herb：The parts by weight of the vine of multiflower knotweed 2~50, light wheat 2~ 100 parts by weight, the parts by weight of RADIX POLYGALAE PREPARATA 2~100, the parts by weight of radix glycyrrhizae 1~50；It is preferred that, it is the parts by weight of the vine of multiflower knotweed 2~25, floating small The parts by weight of wheat 2~50, the parts by weight of RADIX POLYGALAE PREPARATA 2~50, the parts by weight of radix glycyrrhizae 1~25；It is further preferred that the parts by weight of the vine of multiflower knotweed 2, floating The parts by weight of wheat 2, the parts by weight of RADIX POLYGALAE PREPARATA 2, the parts by weight of radix glycyrrhizae 1.
Further, described Chinese medicine composition also includes following Chinese herb：The parts by weight of oriental wormwood 3~100, stringy stonecrop 2~ 50 parts by weight, the parts by weight of rabdosia lophanthide 3~50.
Further, described Chinese medicine composition also includes following Chinese herb：The parts by weight of root tuber of aromatic turmeric 1~100, the red sage root 1~50 Parts by weight, the parts by weight of peach kernel 1~75.
Further, described Chinese medicine composition also includes following Chinese herb：The parts by weight of Paper mulberry Fruit 1~75, radix fici simplicissimae 1~100 parts by weight, the parts by weight of Fructus Corni 1~50.
Further, described Chinese medicine composition be by described Chinese herb it is preprocessed, add water to cook and be concentrated to give leaching Cream, then the medicinal extract of gained is equipped with pharmaceutically acceptable auxiliary material pharmaceutically acceptable liquid preparation or the leaching by gained is made Cream obtains dried cream powder and is equipped with pharmaceutically acceptable auxiliary material again that pharmaceutically acceptable solid pharmaceutical preparation is made after drying.
Further, the mass ratio of described medicinal extract or dried cream powder and pharmaceutically acceptable auxiliary material is 100:2~25, preferably 100:4~25.
Further, described pharmaceutically acceptable auxiliary material is at least one of excipient or odor mask；It is preferred that, it is described Excipient is at least one of beta-schardinger dextrin, mannitol or amylum pregelatinisatum, described odor mask is menthol, peppermint oil or At least one of volatile oil extracted from eucalyptus' leaves or twigs.
Heretofore described liquid preparation is oral liquid, and described solid pharmaceutical preparation is granule, tablet, micropill preparation, capsule Or buccal tablet.
To realize the second object of the present invention, the present invention is adopted the following technical scheme that：
A kind of preparation method of Chinese medicine composition of the present invention comprises the following steps：
1) it is standby after described Chinese herb is pre-processed respectively；
2) pretreated Chinese herb is merged, added water to cook 1~3 time, 1~2 hour every time, collecting decoction was filtered, Merging filtrate, is concentrated into medicinal extract of the relative density at 65 DEG C for 1.05~1.15；
3) medicinal extract obtained by upper step is equipped with pharmaceutically acceptable auxiliary material and pharmaceutically acceptable liquid preparation is made；
Or the extract dry obtained by upper step gets dry extract powder, then dried cream powder is equipped with pharmaceutically acceptable auxiliary material be made pharmaceutically Acceptable solid pharmaceutical preparation.
Be used as a kind of preferred scheme, step 1) described in pretreatment be drying, dry condition is 40~60 DEG C of temperature, is done Dry 4~6 hours time；Step 2) described in add water to cook to add water to cook 3 times, preferably for the first time plus 8 times of amounts decoctings Boil 1.5 hours, the decocting of second plus 4 times amount is boiled 1 hour, the decocting of third time plus 4 times of amounts is boiled 1 hour；Step 3) Described in drying for spray drying.
Further explanation and description of the technical solution of the present invention are carried out below：
The purpose of the present invention is can not thoroughly to remove virus, and recurrence rate height etc. for treatment B type hepatitis antivirus Western medicine at present Feature reduces hepatitis B blood there is provided one kind is cheap, safe and effective, curative effect is reliable, can improve patient's immune level Clear carrying capacity, improves liver function, improves the compound Chinese medicinal preparation and preparation method of life in patients.
Being used for of the present invention prevents and treats the Chinese medicine composition of hepatitis B, its raw material include Moringa, the fruit of glossy privet, the fruit of Chinese magnoliavine, the Radix Astragali, Ganoderma lucidum, Radix Isatidis, roxburgh peristrophe herb, beautiful millettia root, hypericum japonicum and strophanthus divaricatus.
Being used for of the present invention prevents and treats the Chinese medicine composition of hepatitis B, using Moringa, the fruit of glossy privet, the fruit of Chinese magnoliavine, the Radix Astragali, ganoderma lucidum as Monarch drug in a prescription, supplementing qi and nourishing yin, the effect of being immunized with protect liver, liver protection, enhancing；Radix Isatidis, roxburgh peristrophe herb, beautiful millettia root, hypericum japonicum, Strophanthus divaricatus is ministerial drug, clearing heat and promoting diuresis removing toxic substances.
Specifically, Chinese medicine composition of the present invention includes following Chinese herb：The parts by weight of Moringa 2~200, the fruit of glossy privet 3~50 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1~50, the parts by weight of the Radix Astragali 3~100, the parts by weight of ganoderma lucidum 2~50, Radix Isatidis 1~ 50 parts by weight, the parts by weight of roxburgh peristrophe herb 2~100, the parts by weight of beautiful millettia root 1~100, the parts by weight of hypericum japonicum 1~100, strophanthus divaricatus 1~100 parts by weight；It is preferred that, described Chinese medicine composition includes following Chinese herb：The parts by weight of Moringa 2~100, glossy privet Sub 3~25 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1~25, the parts by weight of the Radix Astragali 3~50, the parts by weight of ganoderma lucidum 2~25, Radix Isatidis 1~ 25 parts by weight, the parts by weight of roxburgh peristrophe herb 2~50, the parts by weight of beautiful millettia root 1~50, the parts by weight of hypericum japonicum 1~50, strophanthus divaricatus 1~ 50 parts by weight；It is further preferred that described Chinese medicine composition includes following Chinese herb：The parts by weight of Moringa 2, the weight of the fruit of glossy privet 3 Part, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the parts by weight of roxburgh peristrophe herb 2, The parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of strophanthus divaricatus 1.
The simple of not several same curative effect medicines of Chinese medicine composition of the present invention is piled up, if above-mentioned a few taste medicinal materials are according to this hair Bright Chinese medicine composition dosage is individually taken, and often produces stronger side effect.The present inventor gropes by repetition test, it is determined that When several components reach as above ratio, you can side effect is preferably minimized into limit or even elimination, and therapeutic effect is on the contrary significantly Enhancing.
The present invention is based on the traditional Chinese medical science in the understanding and principle of reatment to hepatitis B, the discovery studied according to modern medicines, compound The medicine of various active ingredients has supplementing qi and nourishing yin, the effect for righting of detoxifying.The mechanism of action for the treatment of by Chinese herbs hepatitis B is main Think have：Suppressing virus replication, transaminase lowering, normalizing gallbladder to cure jaundice, the supply of improvement liver blood, anti-hepatic fibrosis, preventing and treating liver Precancerous lesion, regulation body's immunity, recovery organism balance etc..The present invention provide it is a kind of it is cheap, safe and effective, Curative effect is reliable, can improve patient's immune level, reduces hepatitis B serum carrying capacity, improves the Chinese medicine compound prescription of life in patients Preparation.
To improve curative effect, Chinese medicine composition of the invention can also be helped with the vine of multiflower knotweed, light wheat, RADIX POLYGALAE PREPARATA is soothing the liver relieving mental strain and helping sleep； Radix glycyrrhizae is strengthened the spleen and stomach, coordinating the drug actions of a prescription.Oriental wormwood, red sage root etc. can be added if necessary, strengthen dampness removing, the power of promoting blood circulation.Radix glycyrrhizae help Taste, coordinating the drug actions of a prescription.
If damp and hot obvious person, above-mentioned raw materials also include oriental wormwood, stringy stonecrop, Sculellaria barbata and rabdosia lophanthide；
If the obvious person of extravasated blood sign, above-mentioned raw materials also include the red sage root, root tuber of aromatic turmeric and peach kernel；
If weakened body resistance as obvious person, above-mentioned raw materials also include Paper mulberry Fruit, radix fici simplicissimae and Fructus Corni.
The present invention furthermore provides the preparation method of described Chinese medicine composition, and this method comprises the following steps：
1) it is standby after described Chinese herb is pre-processed respectively；
2) pretreated Chinese herb is merged, added water to cook 1~3 time, 1~2 hour every time, collecting decoction was filtered, Merging filtrate, is concentrated into medicinal extract of the relative density at 65 DEG C for 1.05~1.15；
3) medicinal extract obtained by upper step is equipped with pharmaceutically acceptable auxiliary material and pharmaceutically acceptable liquid preparation is made；
Or the extract dry obtained by upper step gets dry extract powder, then dried cream powder is equipped with pharmaceutically acceptable auxiliary material be made pharmaceutically Acceptable solid pharmaceutical preparation.
The present invention extracts effective ingredient using the method added water to cook commonly used in Chinese pharmacology, and method is simple and easy to apply.
Preferably, step 1) described in pretreatment be drying, dry condition is 40~60 DEG C of temperature, when drying Between 4~6 hours；Step 2) described in add water to cook to add water to cook 3 times, preferably for the first time plus the decoctings of 8 times of amounts boil 1.5 Hour, the decocting of second plus 4 times amount is boiled 1 hour, and the decocting of third time plus 4 times of amounts is boiled 1 hour；Step 3) described in Drying for spray drying.
Decoction is the conventional method of Chinese medicine, but decocts how long how many times, each decoct have a certain impact to medicine. It is preferred with repeatedly decocting than once decocting for a long time.It is the process of composition dissolution in medicine to boil medicine, because after the crude drug immersion aqueous solution, Medicine absorb in itself in a part of water, medicine contained biological alkali salt, glucoside, organic acid and organic acid salt, carbohydrate, The Multiple components such as tannin, protein, pigment, enzyme are nearly all soluble in water, though resin is water insoluble with fat oil, and its Its composition together, can be also partly dissolved, therefore cause concentration difference inside and outside medicinal material, and active ingredient is oozed out from inside to outside from tissue, when Extracellular concentration is equal in medicinal material, i.e., when in poised state, and dissolution stops.Because dissolution is a dynamic equilibrium, if having inside crude drug The ratio for imitating composition and wherein immersion liquid is equal to active ingredient and the ratio of outside immersion liquid outside crude drug, and now drug ingedient cannot be complete Portion's dissolution, it is necessary to filter off decoction and add new solvent water again, make it re-establish concentration difference, be only in this way just conducive to medicinal material into Divide and continue dissolution.
But it is not excessively meddlesome to decoct number of times, because some effective ingredients can decompose it by long-time heating, hydrolysis, While dissolution, drug effect can be also destroyed.And decocting time, should be according to medicine and the property of disease, the difficulty of active ingredient dissolution Easily and depending on medicining condition.
And the decoction Chang Yishui of Chinese medicine is solvent, amount of water used is directly connected to the dissolution of effective component of chinese medicine during decocting herb Situation.By theory reckoning：Amount of water should be evaporation capacity in medicine materical crude slice water absorption, decoction process and decoct after needed for dose summation. But it is difficult dose needed for accurate grasp in practical operation, because it is relevant with medicinal material quality, ingredient, decocting time etc..
The present inventor determines to be advisable to add water to cook 3 times by substantial amounts of experiment, and to add the decoctings of 8 times of amounts to boil 1.5 for the first time Hour, second plus the decoctings of 4 times of amounts boil 1 hour, the decoctings of third time plus 4 times of amounts boil 1 hour be optimal.
In the present invention, when being prepared into liquid preparation, described medicinal extract and the mass ratio of pharmaceutically acceptable auxiliary material are 100:2~ 25, preferably 100:4~25.
When being prepared into solid pharmaceutical preparation, described dried cream powder and the mass ratio of pharmaceutically acceptable auxiliary material are 100:2~25, it is excellent Select 100:4~25.
Described pharmaceutically acceptable auxiliary material is at least one of excipient or odor mask；It is preferred that, described excipient for β- At least one of cyclodextrin, mannitol or amylum pregelatinisatum, described odor mask be in menthol, peppermint oil or volatile oil extracted from eucalyptus' leaves or twigs extremely Few one kind.
Heretofore described liquid preparation is oral liquid, and described solid pharmaceutical preparation is granule, tablet, micropill preparation, capsule Or buccal tablet.
The processing step that the present invention is prepared into above-mentioned formulation is routine operation, and visual medicinal material situation difference takes the circumstances into consideration to change process conditions, Its is known to those skilled in the art.
The present invention has advantages below compared with the medicine of the past treatment hepatitis B：
(1) it can be individually used for being diagnosed as hepatitis B patient；
(2) any western medicine composition is free of, Western medicine can be avoided to bring side effect when in use, increases the therapeutic action of Western medicine, drop The consumption of low Western medicine, it is low-cost；
(3) according to modern pharmacological research, pharmaceutical composition of the invention can liver protection, antiviral, regulation it is immune, to chemistry Property, Alcoholic and immunological liver injury etc. have different degrees of protective effect, have no side effect, safe.
Embodiment
It is below the embodiment of the present invention, described embodiment is rather than the limitation in order to further describe the present invention The present invention.
Embodiment 1, granular preparation
A kind of Chinese medicine composition for preventing and treating hepatitis B, its Chinese herb is by weight ratio：The parts by weight of Moringa 2, glossy privet Sub 3 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, roxburgh peristrophe herb 2 Parts by weight, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, RADIX POLYGALAE PREPARATA 2 Parts by weight, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1.
Preparation method is：
1st, by described Chinese herb by weight ratio, it is dried respectively after weighing up, drying temperature is 60 DEG C, dries 4 Hour；
2nd, Chinese herb after above-mentioned drying is merged, adds water 8 respectively, 4,4 times of amounts are decocted 3 times, decocting time is respectively 1.5h, 1h, 1h, collecting decoction, filtration, merging filtrate, decompression (- 0.05MPa, 65 DEG C) be concentrated into relative density 1.05~ The medicinal extract of 1.15 (65 DEG C), it is the 25% of crude drug amount to extract the rate of extract；
3rd, medicinal extract adds beta-schardinger dextrin and softwood is made, uniform particle is made in rotated formula granulator through drying the powder that gets dry extract； The weight proportion of dried cream powder and beta-schardinger dextrin is 100：25；The above-mentioned particle being made is dried processing, 80 DEG C of drying temperature, Water content control is within 2%；
4th, after particle drying cooling, sieved again, make particle uniform；Wherein every bag 6 grams, equivalent to 20 grams of crude drug；
5th, particle is made after examining, packing through above-mentioned steps, becomes the compound Chinese medicinal preparation for preventing and treating hepatitis B.
The application method for preventing and treating hepatitis B compound Chinese medicinal preparation of the present invention：3 times a day by adult, 1 bag every time, takes after mixing it with water.
Embodiment 2, tablet
A kind of Chinese medicine composition for preventing and treating hepatitis B, its Chinese herb is by weight ratio：The parts by weight of Moringa 2, glossy privet Sub 3 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, roxburgh peristrophe herb 2 Parts by weight, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, RADIX POLYGALAE PREPARATA 2 Parts by weight, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1.
The preparation technology of tablet is：
1st, by described Chinese herb by weight ratio, it is dried respectively after weighing up, 40 DEG C of drying temperature, drying 6 are small When；
2nd, Chinese herb after above-mentioned drying is merged, adds water 8,4,4 times of amounts are decocted 3 times, decocting time be respectively 1.5h, 1h, 1h, collecting decoction, filtration, merging filtrate, decompression (- 0.05MPa, 65 DEG C) are concentrated into relative density 1.05~1.15 The medicinal extract of (65 DEG C), it is the 25% of crude drug amount to extract the rate of extract；
3rd, dried cream powder is obtained after extract dry；
4th, with both dried cream powder and dried starch mixing granulation, using 90 parts of dried cream powder as adhesive, 10 parts of conducts of dried starch are collapsed Agent is solved, tabletting produces (every 0.3 gram, equivalent to crude drug 1 gram).
Embodiment 3, tablet
A kind of Chinese medicine composition for preventing and treating hepatitis B, its Chinese herb is by weight ratio：The parts by weight of Moringa 2, glossy privet Sub 3 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, roxburgh peristrophe herb 2 Parts by weight, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, RADIX POLYGALAE PREPARATA 2 Parts by weight, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1.
The preparation technology of tablet is：
1st, by described Chinese herb by weight ratio, it is dried respectively after weighing up, 50 DEG C of drying temperature, drying time Control was at 5 hours；
2nd, Chinese herb after above-mentioned drying is merged, adds water 8,4,4 times of amounts are decocted 3 times, decocting time be respectively 1.5h, 1h, 1h, collecting decoction, filtration, merging filtrate, decompression (- 0.05MPa, 65 DEG C) are concentrated into relative density 1.05~1.15 The medicinal extract of (65 DEG C), it is the 25% of crude drug amount to extract the rate of extract；
3rd, medicinal extract is obtained into dried cream powder using vacuum spray drying, dry extract is worn into fine powder, add beta-schardinger dextrin, dried cream powder Weight proportion with beta-schardinger dextrin is 100：25；Alcohol granulation is used again, and last tabletting is produced.
Embodiment 4, oral liquid
A kind of Chinese medicine composition for preventing and treating hepatitis B, its Chinese herb is by weight ratio：The parts by weight of Moringa 2, glossy privet Sub 3 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, roxburgh peristrophe herb 2 Parts by weight, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, RADIX POLYGALAE PREPARATA 2 Parts by weight, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1.
The preparation technology of oral liquid is：
1st, by described Chinese herb by weight ratio, it is dried respectively after weighing up, 55 DEG C of drying temperature, drying time Control was at 5 hours；
2nd, above-mentioned dried Chinese herb is merged, adds water 8,4,4 times of amounts are decocted 3 times, decocting time be respectively 1.5h, 1h, 1h, collecting decoction, filtration, merging filtrate, decompression (- 0.05MPa, 65 DEG C) are concentrated into relative density 1.05~1.15 The medicinal extract of (65 DEG C)；
3rd, weigh beta-schardinger dextrin appropriate, add deionized water, supersaturated solution is made, add peppermint oil, beta-schardinger dextrin with it is thin Lotus weight of oil proportioning is 4：0 DEG C of constant temperature of Isosorbide-5-Nitrae, stirs 2 hours, filters solid product after standing, after drying peppermint oil β- Cyclodextrin inclusion compound is crystallized；
4th, above-mentioned medicinal extract and the crystallization of Cyclodextrin inclusion compound are mixed, it is the 0.5% of medicinal extract to make peppermint oil content, addition Xylitol, it is the 5~30% of medicinal extract to make Determination of Xylitol, adds water 10 times and measures, and is mixed, filtering, embedding, sterilization treatment.
Embodiment 5, buccal tablet
A kind of Chinese medicine composition for preventing and treating hepatitis B, its Chinese herb is by weight ratio：The parts by weight of Moringa 2, glossy privet Sub 3 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, roxburgh peristrophe herb 2 Parts by weight, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, RADIX POLYGALAE PREPARATA 2 Parts by weight, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1.
The preparation technology of buccal tablet is：Chinese herb is extracted using the method for embodiment 1 in proportion, merges concentration Liquid, spray drying prepares dried cream powder, is well mixed afterwards with excipient substance, and the mass ratio of dried cream powder and auxiliary material is 100：20, Excipient substance is：Mannitol, menthol, peppermint oil, volatile oil extracted from eucalyptus' leaves or twigs quality proportioning are 50：1：1：1；Low temperature (less than 40 DEG C) Dry, crushed with pulverizer, cross 60 mesh sieves, tabletting.
Embodiment 6, granular preparation
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 2, the weight of the fruit of glossy privet 3 Measure part, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the weight of roxburgh peristrophe herb 2 Part, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, the weight of RADIX POLYGALAE PREPARATA 2 Measure part, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1.
The preparation process be the same as Example 1 of the granular preparation, except that the weight proportion of dried cream powder and beta-schardinger dextrin is 100： 4。
Embodiment 7, granular preparation
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 200, the fruit of glossy privet 50 Parts by weight, the parts by weight of the fruit of Chinese magnoliavine 50, the parts by weight of the Radix Astragali 100, the parts by weight of ganoderma lucidum 50, the parts by weight of Radix Isatidis 50, roxburgh peristrophe herb 100 parts by weight, the parts by weight of beautiful millettia root 100, the parts by weight of hypericum japonicum 100, the parts by weight of the vine of multiflower knotweed 50, the weight of light wheat 100 Part, the parts by weight of RADIX POLYGALAE PREPARATA 100, the parts by weight of strophanthus divaricatus 100, the parts by weight of radix glycyrrhizae 50.
The preparation process be the same as Example 1 of the granular preparation, except that the weight proportion of dried cream powder and beta-schardinger dextrin is 100： 2。
Embodiment 8, oral liquid
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 100, the fruit of glossy privet 25 Parts by weight, the parts by weight of the fruit of Chinese magnoliavine 25, the parts by weight of the Radix Astragali 50, the parts by weight of ganoderma lucidum 25, the parts by weight of Radix Isatidis 25, roxburgh peristrophe herb 50 parts by weight, the parts by weight of beautiful millettia root 50, the parts by weight of hypericum japonicum 50, the parts by weight of the vine of multiflower knotweed 25, the parts by weight of light wheat 50, The parts by weight of RADIX POLYGALAE PREPARATA 50, the parts by weight of strophanthus divaricatus 50, the parts by weight of radix glycyrrhizae 25.
The preparation process be the same as Example 4 of the oral liquid.
Embodiment 9, granular preparation
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 2, the weight of the fruit of glossy privet 3 Measure part, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the weight of roxburgh peristrophe herb 2 Part, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, the weight of RADIX POLYGALAE PREPARATA 2 Measure part, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1, the parts by weight of oriental wormwood 3, the parts by weight of stringy stonecrop 2, the weight of rabdosia lophanthide 3 Part.
The preparation process be the same as Example 1 of the granular preparation.
Embodiment 10, oral liquid
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 100, the fruit of glossy privet 25 Parts by weight, the parts by weight of the fruit of Chinese magnoliavine 25, the parts by weight of the Radix Astragali 50, the parts by weight of ganoderma lucidum 25, the parts by weight of Radix Isatidis 25, roxburgh peristrophe herb 50 parts by weight, the parts by weight of beautiful millettia root 50, the parts by weight of hypericum japonicum 50, the parts by weight of the vine of multiflower knotweed 25, the parts by weight of light wheat 50, The parts by weight of RADIX POLYGALAE PREPARATA 50, the parts by weight of strophanthus divaricatus 50, the parts by weight of radix glycyrrhizae 25, the parts by weight of oriental wormwood 100, the weight of stringy stonecrop 50 Part, the parts by weight of rabdosia lophanthide 50, the parts by weight of root tuber of aromatic turmeric 100, the parts by weight of the red sage root 50, the parts by weight of peach kernel 75.
The preparation process be the same as Example 4 of the oral liquid.
Embodiment 11, granular preparation
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 2, the weight of the fruit of glossy privet 3 Measure part, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the weight of roxburgh peristrophe herb 2 Part, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, the weight of RADIX POLYGALAE PREPARATA 2 Measure part, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1, the parts by weight of oriental wormwood 3, the parts by weight of stringy stonecrop 2, the weight of rabdosia lophanthide 3 Part, the parts by weight of root tuber of aromatic turmeric 1, the parts by weight of the red sage root 1, the parts by weight of peach kernel 1.
The preparation process be the same as Example 1 of the granular preparation.
Embodiment 12, tablet
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 2, the weight of the fruit of glossy privet 3 Measure part, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the weight of roxburgh peristrophe herb 2 Part, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, the weight of RADIX POLYGALAE PREPARATA 2 Measure part, the parts by weight of strophanthus divaricatus 1, the parts by weight of radix glycyrrhizae 1, the parts by weight of oriental wormwood 3, the parts by weight of stringy stonecrop 2, the weight of rabdosia lophanthide 3 Part, the parts by weight of root tuber of aromatic turmeric 1, the parts by weight of the red sage root 1, the parts by weight of peach kernel 1, the parts by weight of Paper mulberry Fruit 1, the parts by weight of radix fici simplicissimae 1, The parts by weight of Fructus Corni 1.
The preparation process be the same as Example 3 of the tablet.
Embodiment 13, buccal tablet
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 100, the fruit of glossy privet 25 Parts by weight, the parts by weight of the fruit of Chinese magnoliavine 25, the parts by weight of the Radix Astragali 50, the parts by weight of ganoderma lucidum 25, the parts by weight of Radix Isatidis 25, roxburgh peristrophe herb 50 parts by weight, the parts by weight of beautiful millettia root 50, the parts by weight of hypericum japonicum 50, the parts by weight of the vine of multiflower knotweed 25, the parts by weight of light wheat 50, The parts by weight of RADIX POLYGALAE PREPARATA 50, the parts by weight of strophanthus divaricatus 50, the parts by weight of radix glycyrrhizae 25, the parts by weight of oriental wormwood 100, the weight of stringy stonecrop 50 Part, the parts by weight of rabdosia lophanthide 50, the parts by weight of root tuber of aromatic turmeric 100, the parts by weight of the red sage root 50, the parts by weight of peach kernel 75, the weight of Paper mulberry Fruit 75 Measure part, the parts by weight of radix fici simplicissimae 100, the parts by weight of Fructus Corni 50.
The preparation process be the same as Example 5 of the buccal tablet.
Embodiment 14, granular preparation
A kind of Chinese medicine composition for preventing and treating hepatitis B, its raw material is by weight ratio：The parts by weight of Moringa 2, the weight of the fruit of glossy privet 3 Measure part, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the parts by weight of ganoderma lucidum 2, the parts by weight of Radix Isatidis 1, the weight of roxburgh peristrophe herb 2 Part, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the parts by weight of strophanthus divaricatus 1.
The preparation process be the same as Example 1 of the granular preparation.
Although the present invention has been presented for some embodiments, it will be appreciated by those of skill in the art that not departing from this hair In the case of bright spirit, embodiments of the invention can be changed.Above-described embodiment is exemplary, not Ying Yiben The embodiment of invention as interest field of the present invention restriction.
Experimental example 1
1 data and method
1.1 general information
The court outpatient 80 between The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med in May, -2015 in May, 2014 is selected, its Middle male 42, female 38；Average age 43.2 years old；The course of disease 3~20 years.All patients meet Chinese Medical Association's hepatopathy Diagnosis in chronic hepatitis B (CHB) guideline of prevention and treatment that credit meeting, the sick credit of Chinese Medical Association's infection can be formulated for 2010 Standard, and A type, the third type, fourth type, penta type, HGV RNA and HIV are excluded, exclude autoimmune disease. And through patient's informed consent, the compliance with partner treatment.
80 are included in observation patient, and a class is that non-rule takes antiviral drugs patient 45, and Equations of The Second Kind is to take anti- Virus drugs person 35, wherein Entecavir tablet person 20 is taken, Sebivo piece 9, other patients 6.Have There is the compliance for coordinating and observing.
1.2 pharmaceutical preparations and usage
The granule that embodiment 1 is prepared；
Usage：1 bag every time, 3 times a day, warm boiled water.
The 1.3 observation courses for the treatment of and efficacy assessment standard
The course for the treatment of is observed with two months for a course for the treatment of.The course for the treatment of terminates, bibliography, formulates curative effect determinate standard as follows：
It is effective：HbeAg turns out cloudy, and HBV-DNA turns out cloudy (＜ 103IU·m L-1), ALT recovers normal；
Effectively：HbeAg, HBV-DNA, ALT are without completely up to standard；
It is invalid：None is up to standard for These parameters.
Efficient=(effective+effectively)/n × 100%
2. result
The traditional Chinese medicine particle preparation that patient takes merely the present invention is controlled at the beginning of 45, through 1 course of therapy effect significantly, is had Efficiency is up to 86.67%.It is shown in Table 1.
Table 1, just control 45 clinical observation total effectses of patient
2.2 former hepatitis B patients 35 take Western medicine person, is agreed to premised on complying with by patient, adds the Chinese medicine group of the present invention Polymer beads preparation, ibid, and same period selection is simple uses Western medicine antiviral agent 35 out-patients of person for usage, by same prison Survey method carries out paired observation, and the Western medicine amount for including observation case is maintained into the initial level observed, one course for the treatment of of medication Afterwards, granular preparation observation curative effect of the present invention is disabled three months, curative effect is summarized as follows.
Table 2, Western medicine add to be contrasted with granular preparation clinical efficacy of the present invention
Contrasted between two groups of groups, in terms of obvious effective rate and total effective rate, be statistically analyzed, be respectively provided with significant difference, P<0.05.
2.3 adverse reactions are observed and counted
Gained observes case in addition to per weekend conventional statistic curative effect and adverse reaction index, special uncomfortable and immediate symptoms such as occurs, Inform that patient reports and taken at any time respective handling.During this group of case observation, do not occur any burst clinical severity, Conventional adverse reaction statistics is as follows, is shown in Table 3.
Table 3
The above results show invention formulation few side effects, are easy to receive safely, two groups of renal function of patients, blood in therapeutic process The indexs such as routine, blood glucose, urine stool routine, electrocardiogram do not have the change of clinical meaning；Not yet discovery is relevant with medicine not Good reaction.
3. conclusion
Chronic hepatitis B is a kind of chronic infectious disease for damaging patient's liver, if liver can be proceeded to by having not been able to timely symptom management The desperate situation such as hardening or hepatocellular carcinoma, the disease has reached 10% in China's incidence of disease, and this not only seriously threatens human body Health, and bring heavy social economical burden to country.The scientific and effective therapeutic scheme of selection of clinical, it has also become people The much-talked-about topic of concern.Treatment chronic hepatitis B there is no particularly effective method, the current western medicine master for the treatment of of hepatitis B at present Nucleoside medicine antiviral therapy is used, suppresses the duplication of hepatitis B, hepatocellular injury degree is reduced, prevents hepatic sclerosis With the generation of liver cancer.Although nucleoside analog antiviral medicine Entecavir, Aldoforwe ester etc. suppress hepatitis B virus duplication, Liver function recovery, prevention liver organization obtain good curative effect because of inflammation in terms of necrosis.But it is due to answering for treating hepatitis B Polygamy, these long term combined uses occur HBV resistances, virus variation or recurred after being discontinued, the side reaction and treatment of medicine Selection of journey etc., is all problem urgently to be resolved hurrily.Chinese traditional treatment hepatitis B, from entirety, diagnosis and treatment, by adjusting certainly Body is immune and promotes autonomous suppression of the body to virus to kill ability, by following the screening of levying property clinical prescription for many years, in clinical treatment Advantage gradually appear.The granular preparation of the present invention derives from natural plants, by means of traditional traditional Chinese medical theory, through for many years Clinical test is screened, and is discarded the dross and selected the essential, and captures the essential ingredient in corresponding plants group, controlling for reliable function curative effect has been made Hepatitis B preparation is treated, the selection of pure natural preparation therapy is provided for hepatitis B patient, can be applied individually to any and just control patient, is treated Effect is definite；Simultaneously to using antiviral drugs patient, curative effect can be increased, or even disable antiviral drugs.This group of case System is observed, and the definite curative effect of this preparation has tentatively been shown.Such as in actual clinical practice, increase use time, it is expected to Obtain more preferable curative effect.Because of the natural plants feature of this medicine, side effect is few, to prolonged application, has established good basis.
Other preparations of Chinese medicine composition of the present invention have same or analogous clinical effectiveness with granular preparation.
Experimental example 2
The different Chinese medicine compositions that the experimental example is used to investigate the present invention cause the protection of acute liver to make to carbon tetrachloride With.
Animal subject：Healthy mice, 30, body weight 20-25g, male and female dual-purpose is randomly divided into 3 groups, every group 10.
Test sample：Sodium chloride injection, 250ml；2.25g, Shangdong Changfu Jiejing Pharmaceutical Industry Co., Ltd.；
The granular preparation of the embodiment of the present invention 1；
The granular preparation of the embodiment of the present invention 14.
Dosage：4 are shown in Table, Normal group and model group give sodium chloride injection.
Experimental method：Mouse is randomly divided into Normal group, model group and each administration group, every group 10 by body weight.It is normal right Sodium chloride injection 20ml/kg is injected intraperitoneally according to group and model group, each administration group dosage as shown in table 4 is given, 1 time every time, Continuous 7 days.After last time administration 2h, Normal group intraperitoneal injection olive oil 10ml/kg, the equal abdominal cavity note of remaining each group Penetrate 0.1% carbon tetrachloride (CCl4) olive oil solution 10ml/kg.Sacrificed by decapitation animal after 20h, takes serum, determines serum paddy Pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) level.Break end after ischemic, hepatic tissue makees routine pathology histological examination.
Experimental result：It is shown in Table 4.Compared with Normal group, model group mice serum ALT and AST level drastically raises (p ＜ 0.01), histopathologic examination finds that hepatic tissue is substantially damaged, and necrosis occurs, illustrates model success.With model group phase Compare, different Chinese medicine composition administration group mice serum ALT and AST water mean poles of the invention significantly reduce (p ＜ 0.01), And liver tissue injury significantly mitigates.
Table 4, the different Chinese medicine compositions of the present invention are to CCl4The comparison of the effect of hepatic injury mouse (N=10)
Group Dosage ALT(U/L) AST(U/L)
Normal group 200ml/kg 151.73±11.62 144.25±10.22
Model group 200ml/kg 481.28±64.61## 346.73±58.75##
The embodiment of the present invention 1 200mg/kg 158.3±74.7** 160.2±28.8**
The embodiment of the present invention 14 200mg/kg 171.2±71.3** 180.5±23.9**
Compared with Normal group：##p<0.01；Compared with model group：**p<0.01.
Conclusion：Carbon tetrachloride enters the main generation lipid oxidation reaction in hepatomicrosome after body, causes liver plasma membrane knot The infringement of structure and function, overflows intracellular ALT, AST, causes ALT, AST activity rise in blood.Hepatic lesion region Bigger, ALT, AST activity are higher.Present invention research finds that different Chinese medicine compositions of the invention can significantly reduce mouse ALT and AST levels in serum, and mitigate liver tissue injury, there is notable protective effect to poisoning mouse liver injury, There is significant curative effect in terms of anti-acute liver damage.

Claims (10)

1. a kind of Chinese medicine composition for being used to prevent and treat virus B hepatitis, it is characterised in that described Chinese medicine composition is included such as Lower Chinese herb：The parts by weight of Moringa 2~200, the parts by weight of the fruit of glossy privet 3~50, the parts by weight of the fruit of Chinese magnoliavine 1~50, the Radix Astragali 3~ 100 parts by weight, the parts by weight of ganoderma lucidum 2~50, the parts by weight of Radix Isatidis 1~50, the parts by weight of roxburgh peristrophe herb 2~100, beautiful millettia root 1~ 100 parts by weight, the parts by weight of hypericum japonicum 1~100, the parts by weight of strophanthus divaricatus 1~100；
It is preferred that, the parts by weight of Moringa 2~100, the parts by weight of the fruit of glossy privet 3~25, the parts by weight of the fruit of Chinese magnoliavine 1~25, the weight of the Radix Astragali 3~50 Measure part, the parts by weight of ganoderma lucidum 2~25, the parts by weight of Radix Isatidis 1~25, the parts by weight of roxburgh peristrophe herb 2~50, the weight of beautiful millettia root 1~50 Part, the parts by weight of hypericum japonicum 1~50, the parts by weight of strophanthus divaricatus 1~50；
It is further preferred that the parts by weight of Moringa 2, the parts by weight of the fruit of glossy privet 3, the parts by weight of the fruit of Chinese magnoliavine 1, the parts by weight of the Radix Astragali 3, the weight of ganoderma lucidum 2 Measure part, the parts by weight of Radix Isatidis 1, the parts by weight of roxburgh peristrophe herb 2, the parts by weight of beautiful millettia root 1, the parts by weight of hypericum japonicum 1, the weight of strophanthus divaricatus 1 Measure part.
2. Chinese medicine composition according to claim 1, it is characterised in that described Chinese medicine composition also includes following Chinese medicine Raw material：The parts by weight of the vine of multiflower knotweed 2~50, the parts by weight of light wheat 2~100, the parts by weight of RADIX POLYGALAE PREPARATA 2~100, radix glycyrrhizae 1~50 Parts by weight；
It is preferred that, the parts by weight of the vine of multiflower knotweed 2~25, the parts by weight of light wheat 2~50, the parts by weight of RADIX POLYGALAE PREPARATA 2~50, radix glycyrrhizae 1~25 Parts by weight；
It is further preferred that the parts by weight of the vine of multiflower knotweed 2, the parts by weight of light wheat 2, the parts by weight of RADIX POLYGALAE PREPARATA 2, the parts by weight of radix glycyrrhizae 1.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that described Chinese medicine composition also includes as follows Chinese herb：The parts by weight of oriental wormwood 3~100, the parts by weight of stringy stonecrop 2~50, the parts by weight of rabdosia lophanthide 3~50.
4. Chinese medicine composition according to claim 3, it is characterised in that described Chinese medicine composition also includes following Chinese medicine Raw material：The parts by weight of root tuber of aromatic turmeric 1~100, the parts by weight of the red sage root 1~50, the parts by weight of peach kernel 1~75.
5. Chinese medicine composition according to claim 4, it is characterised in that described Chinese medicine composition also includes following Chinese medicine Raw material：The parts by weight of Paper mulberry Fruit 1~75, the parts by weight of radix fici simplicissimae 1~100, the parts by weight of Fructus Corni 1~50.
6. the Chinese medicine composition according to claim 1-5 any one, it is characterised in that described Chinese medicine composition is will Described Chinese herb is preprocessed, add water to cook and be concentrated to give medicinal extract, then the medicinal extract of gained is equipped with pharmaceutically acceptable Auxiliary material pharmaceutically acceptable liquid preparation is made or dried cream powder will be obtained after the extract dry of gained is equipped with again pharmaceutically connect Pharmaceutically acceptable solid pharmaceutical preparation is made in the auxiliary material received.
7. Chinese medicine composition according to claim 6, it is characterised in that described medicinal extract or dried cream powder are with can pharmaceutically connect The mass ratio for the auxiliary material received is 100:2~25, preferably 100:4~25.
8. Chinese medicine composition according to claim 7, it is characterised in that described pharmaceutically acceptable auxiliary material is figuration At least one of agent or odor mask；It is preferred that, described excipient be in beta-schardinger dextrin, mannitol or amylum pregelatinisatum at least One kind, described odor mask is at least one of menthol, peppermint oil or volatile oil extracted from eucalyptus' leaves or twigs.
9. a kind of preparation method of the Chinese medicine composition described in claim 1-8 any one, it is characterised in that described preparation Method comprises the following steps：
1) it is standby after described Chinese herb is pre-processed respectively；
2) pretreated Chinese herb is merged, added water to cook 1~3 time, 1~2 hour every time, collecting decoction was filtered, Merging filtrate, is concentrated into medicinal extract of the relative density at 65 DEG C for 1.05~1.15；
3) medicinal extract obtained by upper step is equipped with pharmaceutically acceptable auxiliary material and pharmaceutically acceptable liquid preparation is made；
Or the extract dry obtained by upper step gets dry extract powder, then dried cream powder is equipped with pharmaceutically acceptable auxiliary material be made pharmaceutically Acceptable solid pharmaceutical preparation.
10. preparation method according to claim 9, it is characterised in that step 1) described in pretreatment be drying, Dry condition is 40~60 DEG C of temperature, 4~6 hours drying times；Step 2) described in add water to cook to add water to cook 3 It is secondary, preferably add the decoctings of 8 times of amounts to boil 1.5 hours for the first time, the decocting of second plus 4 times amount is boiled 1 hour, Jia 4 for the third time The decocting of amount is boiled 1 hour again；Step 3) described in drying for spray drying.
CN201610065082.7A 2016-01-29 2016-01-29 It is a kind of to be used to prevent and treat Chinese medicine composition of virus B hepatitis and preparation method thereof Pending CN107019740A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113491741A (en) * 2021-08-27 2021-10-12 首都医科大学附属北京佑安医院 Traditional Chinese medicine composition for treating chronic hepatitis and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1122711A (en) * 1995-09-01 1996-05-22 张永鹏 Hepatitis virus inhibitor and prepn. method thereof

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Publication number Priority date Publication date Assignee Title
CN1122711A (en) * 1995-09-01 1996-05-22 张永鹏 Hepatitis virus inhibitor and prepn. method thereof

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Title
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113491741A (en) * 2021-08-27 2021-10-12 首都医科大学附属北京佑安医院 Traditional Chinese medicine composition for treating chronic hepatitis and application thereof

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