CN1122711A - Hepatitis virus inhibitor and prepn. method thereof - Google Patents
Hepatitis virus inhibitor and prepn. method thereof Download PDFInfo
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- CN1122711A CN1122711A CN95108879A CN95108879A CN1122711A CN 1122711 A CN1122711 A CN 1122711A CN 95108879 A CN95108879 A CN 95108879A CN 95108879 A CN95108879 A CN 95108879A CN 1122711 A CN1122711 A CN 1122711A
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- hepatovirus
- blocker
- radix
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- ganoderma
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The prepn. comprises capillary artemisia, dyer's wood root, root of astragalus membranaceus, fruit of Chinese magnoliavine, fruit of grossy privet, black ant and other Chinese medicines, and is made into bolus, medicinal granules and capsules. It is indicated for hepatitis B, C virus carrier and virus block in incubation period, its effective rate is up to 94.17%.
Description
The present invention relates to a kind of hepatovirus blocker and preparation method thereof, belong to technical field of Chinese patent medicine.
Hepatopathy is a kind of infectious disease bigger to human health damage, and it is first type, B-mode, third type, fourth type and penta type that doctor trained in Western medicine is divided into five types with it.The hepatitis patient of China accounts for about 10% of population according to statistics.Treating this disease method commonly used has following several: (1) vaccine control, have only hepatitis A, Hepatitis B virus vaccine at present, be used for not being subjected to the healthy people of virus infraction and mother and baby's inoculation, preventive effect still can, but because of it costs an arm and a leg, vaccine end still in short supply can be popularized.(2) interferon anti-reflecting virus duplicates, and short-term effect is arranged clinically, but rebound phenomenon is arranged after the drug withdrawal, costs an arm and a leg, and need cost nearly ten thousand yuan a course of treatment, is used for second, hepatitis C patient more.(3) Western medicine liver protecting therapy generally is to use protection and replacement hepatocyte functions such as each biostearin, aminoacid, and its clinical effectiveness is not good.(4) tcm clinical determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs in the existing thousands of years history of China, to improving the clinical symptoms function, reduces HBsAg, falls enzyme certain effect is arranged.As everyone knows, traditional Chinese medical science traditional treatment is executed according to all kinds of clinical symptoms performances of patient and is controlled, therefore the medication of the side of something lost all is evidence-based, yet for second, the malicious patient of the scorching asymptomatic band of hepatitis C, then be that asymptomatic distinguishing do not have according to complying with, therefore the malicious patient of this for a long time asymptomatic band can not get effective treatment, is still blank so far.
The objective of the invention is to overcome the deficiency of prior art existence, a kind of hepatovirus blocker and preparation method thereof is provided, it is the potential second of a kind of blocking-up human body, hepatitis C band cytotoxic drug, makes second, hepatitis C patients can fully recover in bud prophylactic generation in incubation period.Another purpose of invention is to make the epidemic disease poison of stopping in liver, at the regulating YIN and YANG reinforcing body resistance, excite and make virus from going out in the immunologic function rehabilitation course, avoids second, hepatitis C is revivable or become disease grows.In the preparation series 2
#, 3
#, 4
#Preparation system is with 1
#The increase side of main formula combination and usefulness is as 1
#, 2
#Preparation share, and is to be used for that immunologic function is intac just controls the patient, 1
#, 4
#Preparation share, system is used for patient who controls for a long time invalid immunologic function major injury or the like, improved therapeutic effect, the present invention in treatment asymptomatic second, hepatitis C inflammation with the blank of having filled up modern medicine aspect the malicious patient, the liver benefiting health effective percentage is 94.17% in clinical practice, cure rate is 80.1%, and is evident in efficacy.
Implementing technical scheme of the present invention is:
1, hepatovirus blocker prescription (W%) is:
1
#The hepatovirus blocker:
Herba Artemisiae Scopariae 10-20 Radix Isatidis 10-20 Radix Astragali 10-20
Fructus Schisandrae Chinensis 1-10 Fructus Ligustri Lucidi 8-18 XUANJU 8-18
Ganoderma 5-15 Radix Bupleuri 1-5 Radix Paeoniae Rubra 1-10
Lentinus Edodes 10-15 Cordyceps 1-10 Radix Glycyrrhizae 1-5
2
#The hepatovirus blocker:
Herba Artemisiae Scopariae 38-45 Radix Astragali 20-27 Fructus Ligustri Lucidi 12-18
Lentinus Edodes 12-18 Radix Bupleuri 1-8
3
#The hepatovirus blocker:
Radix Isatidis 27-35 Radix Astragali 20-27 Ganoderma 13-18
XUANJU 18-25 Fructus Schisandrae Chinensis 8-15
4
#The hepatovirus blocker:
Lentinus Edodes 25-35 Ganoderma 15-25 XUANJU 15-25
Radix Bupleuri 15-25 Cordyceps 8-15
2, above-mentioned prescription processing procedure is:
A, honeyed pill:
(1) selected each component drug is removed impurity, and the baking room oven dry is sent in chopping, and temperature 30-40 ℃, compatibility in proportion after the oven dry is ground into powder, crosses the 180-230 mesh sieve, and medicamental pulverata is sterilized through disinfection by ultraviolet light, airtight deposit stand-by.
(2) refined honey: select high-quality date anthophorids honey for use, with copper pot or the straight fire heating of stainless-steel pan, the fusing after-filtration is removed impurity, is heated to and boils, temperature is 118-122 ℃, at any time remove floating foam and impurity, boil off moisture, redden with nectarine, be rufous around the foam, with being clamminess that hands is picked up, after leaving, two fingers have white silk, and sticking to one's teeth of chewing is degree.
(3) and the medicine pill: the medicamental pulverata after will sterilizing is put in the good Mel of 60-80 ℃ of refining, and mixing and stirring makes when being cooled to 30-40 ℃ and takes out, and divides the rubbing pill that sticks together, and every ball weighs 9 grams, contains crude drug 5.5 grams.
B, electuary preparation:
The method of pressing honeyed pill (1) is selected with medicine, and roguing, was pulverized the 180-230 mesh sieve at chopping, oven dry, compatibility; add water boil behind the medicamental pulverata sterilization and stir repeatedly, transpiring moisture makes into thick paste, then sucrose is descended dry 2-3 hour at 60 ℃; pulverized the 40-60 mesh sieve; with the thick paste mix homogeneously, be modulated into soft material, agglomerating with what hold; the light pressure then loose for spending; granulate with granulation machine, cross the 12-16 mesh sieve, wet granular is become electuary temperature 60-80 ℃ of following drying.
C, capsule preparations:
Press the method for honeyed pill (1), selected medicine, remove impurity, chopping, oven dry, compatibility in proportion, be ground into the end, cross the sterilization that carries out disinfection of 180-230 mesh sieve, the medicamental pulverata after will sterilizing is then packed into and is met in the enteric O capsule that " food hygiene law " and " law of medicine management " require, and every contains crude drug 0.3 gram.
3, function and curing mainly:
Pestilence is warded off in detoxifcation, and the QI invigorating spermatogenesis excites autoimmune potential, blocking-up hepatitis band poison, transaminase lowering.Be applicable to first, second, third, fourth, penta various hepatitis acute and chronic band poison due to autoimmune defective or the hypofunction, positive or two double one, three, the five positive obstinates of abnormal liver function and hepatitis B HBsAg also can be used for the viral infection or the autoimmune disease of other type.Wherein 1
#Be applicable to various liver class band poison, 2
#Be applicable to new infection or just control patient, 3
#Be applicable to that answering of long-term band poison control the patient, 4
#Be applicable to immunodeficiency, second, hepatitis C band poison obstinate person.
4, usage and dosage:
(1) hepatitis epidemic phase prevention, each oral 1
#Or 2
#6 of honeyed pill 9 grams or electuary 15 grams or capsules, one week of twice logotype every day.
(2) first, second, the scorching band poison of hepatitis C are just controlled the patient, 1
#, 2
#Share, every day, three logotypes were one month.
(3) people that cures the disease again, 1
#, 3
#Share, every day, three logotypes were two months.
(4) immunodeficiency patient, 1
#, 4
#Share, every day, three logotypes were three months.
The present invention compared with prior art has following advantage:
1, hepatovirus blocker of the present invention is treating asymptomatic second, the hepatitis C virus carrier that all kinds of personnel healths find in checking, and the blocking-up of preclinical band poison, or the band poison of second, chronic carrier of hepatitis C later stage effects a radical cure.
2, hepatovirus blocker of the present invention has detoxifcation and wards off pestilence, supplementing QI and nourishing YIN, regulate body's immunity, transaminase lowering promotes the Chinese medicine of hepatocyte self-cleaning from steady effect, is applicable to first, second, third, fourth, penta various hepatitis acute and chronic band poison due to autoimmune function lowly.Positive or two double one, three, the five positive obstinate persons of abnormal liver function and hepatitis B HBsAg.This product selects for use ten pleasant impression Chinese medicines all through strictness screening, and special processing processes in proportion that compatibility forms.
3, hepatovirus blocker taking convenience of the present invention, the short treating period instant effect, the shortest one month, do not have any poison and pay effect, determined curative effect, cure rate 80.1%, effective percentage 94.17%, economic, be easy to large tracts of land and promote.
4, hepatovirus blocker of the present invention, select for use the medicine majority to be used for the control of second, hepatitis C band poison first in the side, no old maxim before full side is synthetic, being used for the treatment of asymptomatic healthy people's second, hepatitis C virus carrier as Herba Artemisiae Scopariae, Radix Isatidis then is initiative, and particularly used Ganoderma, Lentinus Edodes, Cordyceps all is edible fungi that medical value is arranged of this county's specific culture in the side.
Clinical observation on the therapeutic effect:
Do second, the observation of hepatitis C band poison barrier effect well for cooperating the Anyang County epidemic prevention station, since in April, 1993, my institute adopts hepatovirus blocker (original name the liver benefiting health) electuary, honeyed pill, the honey breast made from the international medical group of middle arteries and veins hepatopathy centre of prevention and cure fame, and 96 routine HBsAg positive patients are treated.Wherein male 73 examples, women 21 examples, 17 examples below 20 years old, 20-30 year 40 examples, 30-40 year 23 examples, 40-50 year 8 examples, 50-60 year 4 examples, 2 examples more than 60 years old.
Diagnosis: physical examination, the screening patient, the HBsAg preparing Diagnostic Erythrocyte reverse blood clotting reagent that adopts the Beijing Biological Product Inst., Ministry of Public Health to produce, 1: 8 is above positive, below negative.Positive patients is checked with ELSA fast detecting hepatitis B two double test kit (enzyme linked immunosorbent assay), and 1: 64 is above positive, below negative, or, determine yin and yang attribute by labelling with Ma Xitai---the spotting method model of Peking blue cross Bioisystech Co., Ltd production.Through blood clotting method or positive other feminine gender of enzyme linked immunosorbent assay list HBsAg is a class patient; Is two class patient: HBsAg, HBeAg, resists-the HBC positive through the enzyme linked immunosorbent assay or the equal positive of spotting method HBsAg, HBeAg, and resist-HBS, resists-the HBe feminine gender is three class patients.
Treatment: a class patient uses hepatovirus blocker (original name the liver benefiting health) electuary, first week each 30 restrained, day three times, later on each 15 gram logotype January, each 30 grams of two class patients, days three times logotype February, each 45 grams of three class patients, days three times logotype March, adopt hepatovirus blocker honeyed pill 9 grams to be equivalent to electuary 15 grams, honey breast 5 grams are equivalent to electuary 15 grams.
Finish the course of treatment: one, the two class patient corresponding index blood clotting method positives, enzyme linked immunosorbent assay or spotting method are turned out cloudy to effectively, and it is recovery from illness that the three therapeutic methods of traditional Chinese medicine is all turned out cloudy, and remain stationary or transfer the enzyme mark to or spotting method is positive in invalid by the blood clotting method positive.Three class patient corresponding index HBsAg, HBeAg, anti--HBC positive end change are effectively but anti--anti-HBe of HBS changes sun by the moon, and it is recovery from illness that HBSAg, HBeAg are turned out cloudy by sun.
Therapeutic outcome: a class patient 44 examples are all fully recovered, two classes, 32 examples, 21 examples of fully recovering, effective 29 examples, invalid 3 examples, three classes, 18 examples, 10 examples of fully recovering, effective 15 examples, invalid 3 examples.
Control HBsAg positive patients 206 routine efficacy analysis by clinical examinations of unit consolidation such as Anyang County worker's hospital, county's epidemic prevention station, communication hospitals, city, referring to adnexa I.(the liver benefiting health is a hepatovirus blocker original name in the adnexa).
Embodiment:
1
#Hepatovirus blocker component is: Radix Isatidis 20 grams, and Artemisia anethoicles Mattf 20 grams, the Radix Astragali 20 grams, Fructus Ligustri Lucidi 20 grams, Ganoderma 20 grams, Radix Paeoniae Rubra 10 grams, Fructus Schisandrae Chinensis 10 grams, XUANJU 20 grams, Radix Bupleuri 2 grams, Radix Glycyrrhizae 2 grams, Cordyceps 2 grams, Lentinus Edodes 20 grams amount to 166 grams.The preparation concocting method is:
Honeyed pill: (1) selected each component medicine is removed impurity, and chopping is sent into baking room 30 ℃ of oven dry down, and compatibility is ground into medicamental pulverata and crosses 180 mesh sieves then, and is stand-by through the disinfection by ultraviolet light sterilization.(2) refined honey, select for use high-quality date anthophorids honey to dissolve with the straight fire heating of copper pot, filtering and impurity removing is heated to and boils, and removes floating foam and impurity at any time, boils off moisture, temperature is to 118-122 ° of C, deepen redly with nectarine, be rufous around the foam, with being clamminess that hands is picked up, have white silk after two fingers leave, sticking to one's teeth of chewing is degree.(3) and the medicine pill, back medicamental pulverata 166 grams of will sterilizing are put in good Mel 100 grams of 60-80 ℃ of refining and fully mix, and stirring to make is cooled to 30-40 ℃ of taking-up, divide 30 of the rubbing pills of sticking together, and every ball weighs 9 grams, contains crude drug 5.5 and restrains, and this is all doses.
Capsule preparations: medicamental pulverata 166 grams after the sterilization that will obtain with honeyed pill (1) same procedure, packing into 500 meets in the enteric O capsule that " food hygiene law " and " law of medicine management " require, and every contains crude drug 0.3 and restrains.
Electuary preparation: fall medicamental pulverata 166 grams after the sterilization that obtains with honeyed pill (1) same procedure; adding water 100 grams boils; make into thick paste after stirring transpiring moisture repeatedly; get sucrose 334 and restrain in about 60 ℃ dry 2-3 hour; pulverized the 40-60 mesh sieve; with thick paste and the sucrose mix homogeneously of pulverizing; make soft material; agglomerating with what hold, light press then to loose be degree, with the granulation machine 12-16 mesh sieve of granulating; wet granular is carried out drying under 60-80 ℃; must be in dry electuary 500 grams, one bag of packing of 15 grams then, every bag contains crude drug 6 grams.
2
#Hepatovirus blocker component is: Artemisia anethoicles Mattf 66 grams, and the Radix Astragali 42.5 grams, Fructus Ligustri Lucidi 26.9 grams, Lentinus Edodes 26.9 grams, Radix Bupleuri 3.7 grams amount to 166 grams.
3
#Hepatovirus blocker component is: Radix Isatidis 49.8 grams, and the Radix Astragali 41.5 grams, Ganoderma 24.9 grams, XUANJU 33.2 grams, Fructus Schisandrae Chinensis 16.6 grams amount to 166 grams.
4
#Hepatovirus blocker component is: Lentinus Edodes 49.8 grams, and Ganoderma 26.9 grams, XUANJU 35.2 grams, Radix Bupleuri 35.2 grams, Cordyceps 18.9 grams amount to 166 grams.
Above-mentioned 2
#, 3
#, 4
#The processing procedure of three kinds of dosage forms of hepatovirus blocker is with 1
#The hepatovirus blocker is identical.
Claims (4)
1, a kind of hepatovirus blocker and preparation method thereof is characterized in that:
A hepatovirus blocker prescription (W%) is:
1
#The hepatovirus blocker:
Herba Artemisiae Scopariae 10-20 Radix Isatidis 10-20 Radix Astragali 10-20
Fructus Schisandrae Chinensis 1-100 Fructus Ligustri Lucidi 8-18 XUANJU 8-18
Ganoderma 5-15 Radix Bupleuri 1-5 Radix Paeoniae Rubra 1-10
Lentinus Edodes 10-15 Cordyceps 1-10 Radix Glycyrrhizae 1-5
2
#The hepatovirus blocker:
Herba Artemisiae Scopariae 38-45 Radix Astragali 20-27 Fructus Ligustri Lucidi 12-18
Lentinus Edodes 12-18 Radix Bupleuri 1-8
3
#The hepatovirus blocker:
Radix Isatidis 27-35 Radix Astragali 20-27 Ganoderma 13-18
XUANJU 18-25 Fructus Schisandrae Chinensis 8-15
4
#The hepatovirus blocker:
Lentinus Edodes 25-35 Ganoderma 15-25 XUANJU 15-25
Radix Bupleuri 15-25 Cordyceps 8-15
The above-mentioned prescription processing procedure of B is:
(1) honeyed pill: each component drug is dried through selected remove impurity, the broken baking room of sending into, temperature 30-40 ℃, compatibility in proportion after the oven dry, be ground into powder, cross the 180-230 mesh sieve, medicamental pulverata is sterilized through disinfection by ultraviolet light, good with refining then Mel, be that refined honey carries out and medicine under temperature 60-80 ℃, after abundant mixing and stirring, take out pill when being cooled to 30-40 ℃.
(2) electuary preparation: the medicamental pulverata behind the sterilization that will obtain by the method for producing honeyed pill; adding water boil stirs repeatedly; transpiring moisture makes into thick paste; with sucrose under 60C dry 2-3 hour, pulverized the 40-60 mesh sieve, then with the thick paste mix homogeneously; be modulated into soft material; granulate with granulation machine, cross the 12-16 mesh sieve, wet granular is become electuary temperature 60-80 ℃ of following drying.
(3) capsule preparations: the medicamental pulverata behind the sterilization that will obtain by the method for producing honeyed pill, packing into meets in the enteric O capsule that " food hygiene law " and " law of medicine management " require, and every contains crude drug 0.3 gram.
2, the method for claim 1, the Herba Artemisiae Scopariae of selecting for use in it is characterized in that filling a prescription is the capillary wormwood of gathering spring, Cordyceps is the Cordyceps that takes around the Summer Solstice, the Radix Astragali is to gather the person more than 4 years that grows autumn, Fructus Ligustri Lucidi is the ripe seed of gathering winter, and Ganoderma, Lentinus Edodes are the medicinal first-class kind that Anyang County edible fungi factory cultivates.
3, the method for claim 1, it is characterized in that refining Mel is high-quality date anthophorids honey, with copper pot or the straight fiery heat fused of stainless-steel pan, filter the roguing post-heating to boiling, temperature is 118-122 ℃, removes floating foam and impurity at any time, transpiring moisture, dark red until nectarine, it is thick to become sticky.
4, the method for claim 1 is characterized in that described 1
#The hepatovirus blocker is a main formula, 2
#, 3
#, 4
#The hepatovirus blocker is the side of increasing, both combinations and usefulness in clinical treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95108879A CN1056071C (en) | 1995-09-01 | 1995-09-01 | Hepatitis virus inhibitor and prepn. method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95108879A CN1056071C (en) | 1995-09-01 | 1995-09-01 | Hepatitis virus inhibitor and prepn. method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1122711A true CN1122711A (en) | 1996-05-22 |
| CN1056071C CN1056071C (en) | 2000-09-06 |
Family
ID=5076966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95108879A Expired - Fee Related CN1056071C (en) | 1995-09-01 | 1995-09-01 | Hepatitis virus inhibitor and prepn. method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1056071C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093765C (en) * | 1999-08-03 | 2002-11-06 | 孙成斋 | Chaiqi injection for treating viral hepatitis |
| US7648717B2 (en) * | 2003-06-13 | 2010-01-19 | Industrial Technology Research Institute | Herbal extract having anti-virus activity and preparation of same |
| CN107019740A (en) * | 2016-01-29 | 2017-08-08 | 左俊岭 | It is a kind of to be used to prevent and treat Chinese medicine composition of virus B hepatitis and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090183A (en) * | 1993-01-28 | 1994-08-03 | 奥忠友 | Artemisia scoparia and ginseng pellet for mourishing liver and method for production thereof |
| CN1052157C (en) * | 1993-06-30 | 2000-05-10 | 付军廷 | Softing liver and contracting spleen tablet |
-
1995
- 1995-09-01 CN CN95108879A patent/CN1056071C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093765C (en) * | 1999-08-03 | 2002-11-06 | 孙成斋 | Chaiqi injection for treating viral hepatitis |
| US7648717B2 (en) * | 2003-06-13 | 2010-01-19 | Industrial Technology Research Institute | Herbal extract having anti-virus activity and preparation of same |
| CN107019740A (en) * | 2016-01-29 | 2017-08-08 | 左俊岭 | It is a kind of to be used to prevent and treat Chinese medicine composition of virus B hepatitis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1056071C (en) | 2000-09-06 |
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