CN1144097A - Longzhusan powder - Google Patents
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Abstract
The Chinese medicine Longzhusan powder is used for curing Parkinson's disease, it can obviously improve symptoms of tremor and myotonia, raise immunologic fucntion and improve microcirculation. Its effective rate can be up to 98%, effectual rate can be up to 74.5%. Said invention is made up by using 15 Chinese herbal medicines of Chinese angelica root and Chuanxiong rhizome, etc. and making them pass through such processes as water-extraction and concentration to obtain a concentrated solution. The other 15 Chinese medicinal materials of earthworm and pearl, etc are pulverized into fine powder, and added into the above concentrated solution, and then made into the invented powder preparation by conventional method.
Description
The invention belongs to technical field of Chinese medicines.
Parkinson disease have another name called Parkinsonism, the tremble category of disease or liver-wind of traditional Chinese medical science ownership, in, the modal extrapyramidal system disease of old people.Primary disease can be taked surgical operation therapy according to the literature, for example adopt brain biological tissue transplantation, obviously, this kind operation is difficult to promote at present, still be in the experimentation stage, though and operation can produce better effects to some cases, effect duration only be 3-6 individual month (the 109th page of clinical neurology magazine the 2nd phase of nineteen ninety).Therefore primary disease mainly relies on Drug therapy at present.The principal character of primary disease is that the intrastriatal DOPAMINE CONTENT IN RABBIT of patient's brain reduces, and has two class chemicalses to be used for the treatment of to this: (1) dopamine substituting agent such as L-DOPA, madopar etc.(2) dopamine-receptor stimulant and promoter are as Pravidel and amantadine.But up to now, though above-mentioned various medicine can reduce patient's misery, can not stop the primary disease organic growth, curative effect is also not ideal enough.Toxicity, side effect is serious simultaneously, and the medicine attenuation effect is obvious.With the higher Carbidopa of present curative effect is example, and effective percentage is 76.9% (obvious effective rate 29.4%) in the recent period, and effective percentage was 69.8% in 2 years, effective percentage was 51.5% in 3 years, and along with the prolongation of administration time, curative effect reduces (attenuation effect is obvious) gradually, the state of an illness day by day increases the weight of, and side effect constantly increases.Its side effect comprises four aspects: (1) gastrointestinal symptom, along with administration time increases, this type of symptom incidence rate almost can reach 100%.(2) cardiovascular symptom, incidence rate is about 15-35%.(3) mental symptom is as depression, anxiety etc.(4) motor symptoms is as hyperkinetic syndrome etc.Of a great variety and prolong the toxicity, side effect increase the weight of with medication period, often can force treatment to be interrupted.
Aspect traditional Chinese medicine, think that primary disease mostly is deficiency of the liver and kindey, QI and blood deficiency, excessive rising of liver-YANG, qi depression to blood stasis, muscle arteries and veins are lost and are supported stirring-up of pathogenic wind in the interior resulting from deficiency etc., but in many reports, both lacked strict diagnostic criteria and clear and definite classification, do not had objective determination and experimental data (1988 the 5th phase page 4 of the clinical immune magazine of Chinese experimental) again.Report (in March, 1985, scientific and technical literature publishing house published clinical 456 pages of the collection second editions of testing of Wang Zhanxi chief editor) at useful BUYANG HUANWU TANG treatment primary disease aspect the treatment prescription, being of being reported is individual routine, must add and subtract with disease during concrete the application, form new side, just can obtain certain curative effect, and used dosage form is traditional decoction.As everyone knows, Chinese medicine decoction often is subjected to multiple factor affecting such as crude drug source, decocting time, the water yield, concentrating degree, fried number of times, the duration and degree of heating, and does not have quality standard, is difficult to control pharmacy quality.Therefore this therapeutic outcome often lacks representativeness.Once contrasted treatment with the present invention and BUYANG HUANWU TANG in the present invention, presentation of results BUYANG HUANWU TANG curative effect is not good enough.Above-mentioned situation explanation treatment parkinson disease still lack comparatively effectively and the medicament of safety so far.
The present invention does not see identical with the present invention or similar report (Shanghai scientific-technical information institute retrieval numbering 93180 is retrieved May 27 1993 date) through the institute retrieval of Shanghai scientific-technical information.
The object of the present invention is to provide and a kind ofly form with kinds of traditional Chinese medicines such as Pheretima, Margaritas, take Chinese drugs agentia preparation technology, make the medicament that is fit to clinical practice, this medicament main uses is the treatment parkinson disease, can obviously improve Parkinsonian trembling and symptom such as myotonia, improves immunologic function, microcirculation improvement, the normal phase do not have the effect attenuation effect of Western medicine when taking, and overcome the critical defect that Western medicine can not stop PD, do not have obvious toxicity, side effect.
The objective of the invention is to be achieved through the following technical solutions.
The preparation of Longzhusan powder
1. write out a prescription: the stiff silkworm 2-8 of earthworm 2-8 part pearl 6-24 part part pangolin 2-6 part rhizoma Gastrodiae 2-6 part long-nosed pit viper 2-6 part tortoiseshell 2-6 part cicada moves back the blue or green chlorite schist 1-3 of 2-8 part goat's horn powder 0.4-1 part peach kernel 2-6 part jujube kernel 2-6 part Radix Angelicae Sinensis 2-6 part Ligusticum wallichii 2-8 part safflower 2-6 part cultivated land 1-4 part Poria cocos 1-4 part bighead atractylodes rhizome 1-4 part Radix Astragali 4-12 part fruit of Chinese wolfberry 6-24 part RADIX POLYGONI MULTIFLORI PREPARATA 2-8 part grass-leaved sweetflag 1-6 part arisaema cum bile 1-4 part root of bidentate achyranthes 2-6 part rheum officinale 1-4 part ochre 1-3 part magnetite 1-2 part part plantain seed 2-4 part lycopodium calvatum 1-4 part root tuber of aromatic turmeric 1-6 part.
Annotate one: Margarita is meant natural peral or cultured pearl or Concha Margaritifera in the prescription.
Annotate two: the Cornu Caprae seu Ovis powder is meant Cornu Saigae Tataricae powder or Cornu Naemorhedi powder in the prescription.During with the Cornu Naemorhedi powder, consumption can increase by 1 times.
2. technical process: with Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Lycii, Radix Polygoni Multiflori Preparata, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Semen Plantaginis, Herba Lycopodii, Radix Curcumae, after 50-60 ℃ of oven dry, pulverize, cross 40 mesh sieves.To sieve then the coarse powder break into portions, with bundle it, insert in the decocting medicine pot, add water to and exceed medicine, be heated to and boil, be incubated 2 hours, the leaching medicinal liquid, residue decocts with water 1.5 hours according to last method, filters and squeeze medicinal liquid is all leached.Merge twice and filter the gained medicinal liquid, concentrate, get standby medicinal liquid.
Other gets all other medicines dryings, pulverizing except that above-mentioned Chinese medicine in the prescription, behind 60 mesh sieves, mixes with the standby medicinal liquid that makes above excessively, promptly gets the former medicine of Longzhusan powder.
The former medicine of Longzhusan powder is added appropriate amount of auxiliary materials such as starch, Mel, sugar and so on, can make Longzhusan powder powder or electuary by Chinese powder medicine or the processing of electuary routine fashion.
The former medicine of Longzhusan powder is added appropriate amount of auxiliary materials such as Mel etc.,, can make the Longzhusan powder honeyed pill by known Chinese medicine big honeyed pills routine fashion processing.
The former medicine of Longzhusan powder is added appropriate amount of auxiliary materials as sugar, Mel etc., press the processing of Chinese medicine unguentum routine fashion, can make the Longzhusan powder unguentum.
The former medicine adding appropriate amount of auxiliary materials of Longzhusan powder such as microcrystalline Cellulose or starch etc. can be made the Longzhusan powder tablet by the processing of Chinese medicinal tablet routine fashion.
With the former medicine drying of Longzhusan powder, pulverizing, sieve after, press Chinese medicinal capsule agent routine fashion processing, can make capsule.
The former medicinal known method of Longzhusan powder suitably still can be produced other form of Chinese drug after the processing.
3. usage and purposes: the Longzhusan powder main uses is the treatment parkinson disease.
Usage: oral, each 9 grams of powder or electuary, every day 2-3 time.Each oral former medicine 8 grams of Longzhusan powder that are equivalent to during other dosage forms, every day 2 once.3-6 month was 1 course of treatment.
Clinical research result of the present invention
1. Longzhusan powder and Western medicine (Carbidopa or L-DOPA) treatment parkinson disease curative effect is relatively:
Efficacy assessment standard is by international Webster scoring method, and with parkinson disease ten big symptom score, promptly each symptom is divided into level Four, and normal 0 minute, slight undesired 1 minute, undesired 2 minutes of moderate, serious undesired 3 minutes.With ten big symptom mark additions, be light disease patient below 10 minutes at last, 11-21 is divided into the moderate patient, and 21-30 is divided into critically ill patient.The back score value slip of taking medicine is produce effects more than 61% what marked originally.The back score value slip of taking medicine is effectively at the 31-60% of original scoring.The back score value slip of taking medicine is that invalid (Chinese Pharmacological magazine, Chinese Pharmacological proving ground are about Parkinsonism new medicament screen judgment criteria 1,990 30% below in original scoring; The II phase)
The score formula:
Therapeutic outcome:
Presentation of results score value slip after the Longzhusan powder group was taken medicine 1 month reaches effective standard more than 30%, and 6 months score value slips of taking medicine can surpass more than 60%, reach the produce effects standard.Scoring changes not quite before and after the western medicine group treatment, and expression only can be kept patient's present situation, fails progressively to improve.The two is compared, and difference is very remarkable.
2. Longzhusan powder and BUYANG HUANWU TANG treatment parkinson disease curative effect relatively
Ten doing well,improving situations relatively before and after Longzhusan powder and the BUYANG HUANWU TANG medication
No matter Longzhusan powder group therapeutic outcome is pressed the evaluation of Webster scoring method as can be seen from the above table, still press the doing well,improving average evaluation, all obviously be better than the BUYANG HUANWU TANG group.The two has highly significant difference P＜0.01.
3. Longzhusan powder and Western medicine administering drug combinations and simple western medicine treatment parkinson disease relatively
After the presentation of results treatment 1 month, the administering drug combinations group of Longzhusan powder+Western medicine with give Western medicine merely relatively, the two score value slip has highly significant difference, and along with treatment time prolongs, difference is increasing.This has synergism, therapeutic effect to outclass simple use Western medicine when proving absolutely Longzhusan powder and Western medicine drug combination.
4. Longzhusan powder is treated parkinson disease 66 routine own control therapeutic outcomes
Up to 98%, obvious effective rate reaches 74.5% from own control therapeutic outcome explanation Longzhusan powder effective percentage.
5. Longzhusan powder is except the clinical symptoms and sign that can improve the parkinson patient, and aspect objective test rating, some the detection indexs as in thyroid function, immunologic function and the hemorheology all have obvious improvement:
One, thyroid function
Longzhusan powder treatment parkinson disease 66 routine thyroid function own control results
| The inspection item title | Before the Longzhusan powder treatment | After the Longzhusan powder treatment | The P value |
| Trilute (T 3) thyroxine (T 4) | ?1.12±0.35mmol/L ?78.1±15.9mmol/L | 1.39±0.31mmol/L 113.2±14.7mmol/L | ＜0.05 ＜0.01 |
Once antithyroglobulin (TGAB) and the little protamine of antithyroid (TMAB) were carried out the comparison of Longzhusan powder treatment front and back in addition, all there were significant differences for the result, P＜0.01.
Two, immunologic function
Longzhusan powder treatment parkinson disease 66 routine immunology detection index own control results
| The inspection item title | Before the Longzhusan powder treatment | After the Longzhusan powder treatment | The P value |
| Serum immune globulin M (IgM) E-rosette forming cell (E tRFC) lymphocyte transformation test (LT) | ????0.12±0.5g/L ????3.76±4.7％ ????40.2±24.1％ | ????0.13±0.5g/L ????53.8±6.7％ ????61.3±7.5％ | ＜0.05 ＜0.01 ＜0.01 |
Three, hemorheology
Longzhusan powder treatment parkinson disease 66 routine hemorheology own control results
| The inspection item title | Before the Longzhusan powder treatment | After the Longzhusan powder treatment | The P value |
| The whole blood thickness than (low cut) blood plasma thickness than (height is cut) red blood cell hematocrit (%) | ????5.26±0.29 ????1.81±0.3 ????46.8±1.58 | ????4.35±0.83 ????1.62±0.36 ????44.1±1.6 | ＜0.01 ＜0.05 ＜0.01 |
6. Longzhusan powder is treated 66 routine parkinson disease toxic and side effects observed results: observe and repeatedly follow up a case by regular visits to and check through the 1-3 treatment, do not see obvious toxicity.
The present invention has following advantage compared with the prior art
1. the present invention is evident in efficacy to parkinson disease through clinical confirmation, can obviously improve parkinson patient symptom and sign, and effective percentage can reach 98%, and obvious effective rate can reach 74.5% far above Western medicine DOPA class medicine, also is much higher than Chinese medicine prescription BUYANG HUANWU TANG.
2. the present invention is different with DOPA and so on Western medicine, is not temporaryly replenish to substitute in the body the insufficient dopamine substituting agent of dopamine or the dopaminergic receptor swashs young agent, but a kind ofly has many-sided effect, treats the parkinson disease medicine on the whole.
3. the present invention can significantly improve parkinson patient's immunologic function, some critical functions in thyroid function and the hemorheology.
4. the present invention is humble through clinical confirmation toxic and side effects, and the serious toxic and side effects that does not have Western medicine to exist is a safe drugs.
5. the present invention does not take for a long time and can produce the medicine attenuation effect, thereby has guaranteed the needs of patient's long-term treatment.
6. the present invention is different from the Chinese medicine decoction, can be made into powder, decoction, electuary, tablet or the like modern formulation, take easy, carrying convenience.
7. the present invention has scientific and reasonable production technology, is convenient to produce.
8. product quality of the present invention can be controlled, and product quality has abundant assurance.
The embodiment of the invention:
Prescription: the stiff silkworm 100 gram pangolins of earthworm 100 gram pearls 300 grams 100 gram rhizoma Gastrodiaes 100 gram long-nosed pit vipers 100 gram tortoiseshells 100 gram cicada move back 100 gram Cornu Saigae Tataricae powders, 25 gram peach kernels, 100 gram jujube kernels, 50 gram Radix Angelicae Sinensis, 50 gram Ligusticum wallichiis, 100 gram safflowers, 50 gram cultivated lands, 50 gram Poria cocos, the 50 gram bighead atractylodes rhizomes, the 50 gram Radixs Astragali, the 100 gram fruits of Chinese wolfberry 300 and restrain the tubers of multiflower knotweed 100 gram grass-leaved sweetflags 50 gram arisaema cum bile 50 gram roots of bidentate achyranthes 100 gram rheum officinales 50 gram ochres 25 grams magnetite 25 gram blue or green chlorite schist 25 gram plantain seed 50 gram lycopodium calvatum 100 gram root tuber of aromatic turmeric 50 gram.
Preparation method: with Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Lycii, Radix Polygoni Multiflori Preparata, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Semen Plantaginis, Herba Lycopodii, Radix Curcumae, after 50-60 ℃ of oven dry, pulverize, cross 40 mesh sieves.To sieve then the coarse powder break into portions, with bundle it, insert in the decocting medicine pot, add water to and exceed medicine, be heated to and boil, be incubated 2 hours, the leaching medicinal liquid, residue decocts with water 1.5 hours according to last method, filters and squeeze medicinal liquid is all leached.Merge twice and filter the gained medicinal liquid, concentrate, get concentrated solution.Other gets in the prescription all other medicines except that above-mentioned Chinese medicine, drying, pulverizing, mix with above-mentioned concentrated solution after crossing 60 mesh sieves, make the former medicine of Longzhusan powder (I), add adjuvants such as proper honey, starch again and make granule, in 50-60 ℃ of oven dry, pulverize then, cross 100 mesh sieves, be loaded in the packaging bag by every bag 9 gram, vacuum seal promptly.
Annotate: Margarita can replace with Concha Margaritifera in the prescription.Cornu Saigae Tataricae powder can replace with the Cornu Naemorhedi powder, and during with the Cornu Naemorhedi powder, consumption can increase by 1 times.
Usage: each oral 1 bag (9 gram), day clothes 2-3 time.
Purposes: treatment parkinson disease
The present invention changes embodiment:
1. will make the former medicine of Longzhusan powder (I) in the foregoing description, carry out drying back pulverizing, make medicine pill with water pill again.
2. will make the former medicine of Longzhusan powder (I) in the foregoing description, add refined honey, the ECDC medicine is rubbed operations such as ball with the hands, makes Chinese medicine pill.
3. will make the former medicine of Longzhusan powder (I) in the foregoing description, add adjuvants such as starch, dextrin, make tabletting behind the granule, make Chinese medicinal tablet.
4. will make the former medicine of Longzhusan powder (I) in the foregoing description, the suitable model capsule of packing into behind the drying pulverizing promptly gets the Chinese medicinal capsule agent.
5. with making the former medicine of Longzhusan powder (I) in the foregoing description, add an amount of sucrose, or behind the Mel, make the Chinese medicine unguentum through suitably concentrating.
Claims (5)
1. herbal mixture Longzhusan powder is characterized in that the prescription of described herbal mixture Longzhusan powder is: the stiff silkworm 2-8 of earthworm 2-8 part pearl 6-24 part part pangolin 2-6 part rhizoma Gastrodiae 2-6 part long-nosed pit viper 2-6 part tortoiseshell 2-6 part cicada moves back the blue or green chlorite schist 1-3 of 2-8 part goat's horn powder 0.4-1 part peach kernel 2-6 part jujube kernel 2-6 part Radix Angelicae Sinensis 2-6 part Ligusticum wallichii 2-8 part safflower 2-6 part cultivated land 1-4 part Poria cocos 1-4 part bighead atractylodes rhizome 1-4 part Radix Astragali 4-12 part fruit of Chinese wolfberry 6-24 part RADIX POLYGONI MULTIFLORI PREPARATA 2-8 part grass-leaved sweetflag 1-6 part arisaema cum bile 1-4 part root of bidentate achyranthes 2-6 part rheum officinale 1-4 part ochre 1-3 part magnetite 1-2 part part plantain seed 2-4 part lycopodium calvatum 1-4 part root tuber of aromatic turmeric 1-6 part. Preparation method is:with Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Lycii, Radix Polygoni Multiflori Preparata, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Semen Plantaginis, Herba Lycopodii, Radix Curcumae, 50-60 ℃ of of of oven of pulverize after dry, cross 40 mesh sieves.To sieve then the coarse powder break into portions, with bundle it, insert in the decocting medicine pot, add water to and exceed medicine, be heated to and boil, be incubated 2 hours, the leaching medicinal liquid, residue decocts with water 1.5 hours according to last method, filters and squeeze medicinal liquid is all leached.Merge twice and filter the gained medicinal liquid, concentrate, get standby medicinal liquid.
Other gets in the prescription all other medicines except that said medicine, drying, pulverizing, cross 60 mesh sieves after, mix with above-mentioned standby medicinal liquid, promptly get the former medicine of Longzhusan powder.This former medicine is added appropriate amount of starch again and other adjuvants are made granule, after 50-60 ℃ oven dry, pulverize, cross 100 mesh sieves, carry out packing, every bag 9 gram.
Usage is: obey each 1 bag (9 gram) after 15-20 minute with the immersion of boiling water 100-200 milliliter.Every day 2-3 time.Also can be directly oral, each 9 grams send down with eliminating cold for resuscitation water.
Purposes is: be mainly used in the treatment parkinson disease.
2. according to the described herbal mixture Longzhusan powder of claim 1, it is characterized in that Margarita is meant natural peral or cultured pearl or Concha Margaritifera in the prescription.
3. according to the described herbal mixture Longzhusan powder of claim 1, it is characterized in that the Cornu Caprae seu Ovis powder is meant Cornu Saigae Tataricae powder or Cornu Naemorhedi powder in the prescription, during with the Cornu Naemorhedi powder, consumption can increase by 1 times.
4. according to the described herbal mixture Longzhusan powder of claim 1, it is characterized in that making the former medicine of Longzhusan powder by preparation method, available existing Chinese patent medicine prepares known technology and is processed into other form of Chinese drug such as tablet, capsule, pill, unguentum.
5. according to the described herbal mixture Longzhusan powder of claim 1, the best proportioning of Chinese medicine that it is characterized in that respectively distinguishing the flavor of in the prescription is:
4 parts of Cicadaes of 4 parts of Carapax et Plastrum Testudiniss of 4 portions of Agkistrodons of 4 parts of Rhizoma Gastrodiaes of 4 parts of Squama Maniss of 12 parts of Bombyx Batryticatus of 4 parts of Margaritas of Pheretima (or Concha Margaritifera) move back 2 parts of 4 portions of Radix Curcumaes of 2 parts of Herba Lycopodiis of 1 portion of Semen Plantaginis of 1 part of Lapis Chloriti of 1 part of Magnetitum of 2 parts of Haematitums of 4 parts of Radix Et Rhizoma Rhei of 2 parts of Radix Achyranthis Bidentataes of 2 parts of Arisaema Cum Bile of 4 parts of Rhizoma Acori Graminei of 12 parts of Radix Polygoni Multiflori Preparata of 4 parts of Fructus Lycii of 2 parts of Radixs Astragali of 2 parts of Rhizoma Atractylodis Macrocephalaes of 2 parts of Poria of 2 parts of Radix Rehmanniaes Preparata of 4 parts of Flos Carthamis of 2 parts of Rhizoma Chuanxiongs of 2 parts of Radix Angelicae Sinensis of 4 parts of Semen Ziziphi Spinosaes of 1 part of Semen Persicae of 4 parts of Cornu Saigae Tataricae powders.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93111386 CN1144097A (en) | 1993-08-03 | 1993-08-03 | Longzhusan powder |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93111386 CN1144097A (en) | 1993-08-03 | 1993-08-03 | Longzhusan powder |
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| CN1144097A true CN1144097A (en) | 1997-03-05 |
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- 1993-08-03 CN CN 93111386 patent/CN1144097A/en active Pending
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| CN104042695A (en) * | 2014-07-04 | 2014-09-17 | 伏广珍 | Compound rheum officinale medicine for treating Parkinson's disease (PD) as well as preparation method and application thereof |
| CN104547949A (en) * | 2015-01-22 | 2015-04-29 | 张宏伟 | Traditional Chinese medicine for treating tremor syndrome |
| CN118634302A (en) * | 2024-08-15 | 2024-09-13 | 中国中医科学院中医基础理论研究所 | Traditional Chinese medicine composition for treating parkinsonism, traditional Chinese medicine preparation, preparation method and application thereof |
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