CN102743456B - The application of a kind of Chinese medicine composition in the medicine of preparation control delayed encephalopathy after acute carbon monoxide poisoning - Google Patents

Abstract

The invention discloses the application of a kind of Chinese medicine composition in the medicine preparing prevention and therapy delayed encephalopathy after acute carbon monoxide poisoning.Chinese medicine composition of the present invention is made up of Radix Ginseng, Hirudo, Scolopendra, Scorpio, Eupolyphaga Seu Steleophaga, Periostracum Cicadae, Radix Paeoniae Rubra, Borneolum Syntheticum etc., has effect of benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral.Clinical studies show, Chinese medicine composition of the present invention has definite preventive and therapeutic action to Delayed Encephalopathy Caused.

Description

The application of a kind of Chinese medicine composition in the medicine of preparation control delayed encephalopathy after acute carbon monoxide poisoning

Technical field

The present invention relates to a kind of novelty teabag of Chinese medicine composition, particularly, the present invention relates to the application of a kind of Chinese medicine composition in the medicine preparing prevention and therapy delayed encephalopathy after acute carbon monoxide poisoning, belong to application in TCM field.

Background technology

Delayed encephalopathy after acute carbon monoxide poisoning (delayed encephalopathy after acute carbon monoxide poisoning;) refer to that acute carbon monoxide (CO) poisoning patient is through rescuing after acute poisoning glucose recovery, act normally through a couple of days or several weeks or after close normal " latent phase ", again occur one group of neuropsychic symptom based on psychoplegia.Generally occur in two months after acute poisoning, disability rate and mortality rate higher, still lack effective treatment means.Its sickness rate of domestic and international report is about 2% ~ 8%, and in patient with severe symptoms, incidence rate can up to 30% ~ 40%.Therefore, the prevention of the poisoning rear Delayed Encephalopathy Caused of CO is seemed particularly important.

DEACMP clinical characters is after disturbance of consciousness recovers, and again occurs the change such as neuropsychiatric abnormalities, intelligence, personality, behavior, even again go into a coma through one section after seeming normal latent phase.Pathogenesis is complicated, and illustrate not yet completely so far, the most popular is microcirculation disturbance theory.After acute CO poisoning, cerebral anoxia causes Secondary cases microvascular lesions, the wall of micrangium endotheliocytic swelling degeneration of anoxia and permeability increases, blood oozes out or intravenous congestion from blood vessel wall, cause artery occlusive intimitis and microthrombusis, then cause cerebral anoxia edema, brain cell necrosis, alba demyelination sample to change.Above-mentioned pathological change needs certain hour from functional to organic, therefore patient can regain consciousness through after a while from going into a coma to, occurs neuropsychic symptom again.The generation of primary disease and age, occupation, stupor time and stopping too early treating or because of mistaken diagnosis the many reasons such as wrong treatment treatment relevant, wherein the age is more than 50 years old, and is engaged in mental work, and the stupor time gets over elder, and the probability of Late-onset encephalopathy is larger.Once generation Delayed Encephalopathy Caused, its course of disease is long, treatment difficulty, and be difficult to correct, the prevention of primary disease overweights treatment as can be seen here.

Hyperbaric oxygen is the major measure for the treatment of carbon monoxide poisoning.Hyperbaric oxygen can accelerate the decomposition of carboxyhemoglobin, promotes the removing of carbon monoxide, recovers the function of carrying oxygen of hemoglobin; During hyperbaric oxygentherapy, blood plasma dissolved oxygen rolls up, and blood oxygen pressure improves, and can correct rapidly histanoxia state, improve cerebral anoxia, promote that central nervous system function is recovered, but this restitution for cerebral tissue is slowly.

Motherland's medical science there is no " Delayed Encephalopathy Caused " this name of disease, but combine its clinical with forgetful, slow-witted, stupid, stupid, stupid etc. for principal character, categories such as Chinese medicine " silly demonstrate,prove " " dementia " should be belonged to.We start with from veins disease theories is dialectical, think that CO does not belong to the heresy of the diseases caused by exogenous pathogenic factor that the traditional Chinese medical science is said, when being the special poison heresy of one, from mouth and nose invasion viscera meridians, poison damages brain network, brain god apraxia, with the passing of time channels stasis blocking, QI and blood is lost and is supported, and causes again network void not flourish, forms the card of simulataneous insufficiency and excessive.Channels is that disease has the easy stagnant easy stasis of blood, easily enters the feature that difficulty goes out, and then causes primary disease long for incubation period, exacerbation of symptoms after recurrence.

The present invention is the improvement invention carried out on the basis of No. 01131203.3 and No. 200410048292.2 patent, quotes in full the content of this two patent document record at this.

Summary of the invention

The object of the invention is to provide the application of a kind of Chinese medicine composition in the medicine preparing prevention and therapy delayed encephalopathy after acute carbon monoxide poisoning, and described Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (processed) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5 Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (parched) 3-10;

Preferably, this Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophaga 7 Olibanum (processed) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 7 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched) 5;

Or:

Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophaga 7 Olibanum (processed) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 9 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched) 5;

Or:

Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophaga 7 Olibanum (processed) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 3 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched) 5;

More preferably, the active component of above-mentioned Chinese medicine composition is made up of following ingredients:

A mean diameter be less than 100 μm Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and Olibanum (processed) medicated powder;

B Borneolum Syntheticum medicated powder;

The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;

The alcohol-extracted extract of alcohol extract after d Radix Ginseng ethanol extraction after concentrated;

The water extracted immersing paste that the Aqueous extracts of the Aqueous extracts after the Aqueous extracts of the Lignum Dalbergiae Odoriferae after e extract component c and Lignum Santali Albi medicinal residues, Radix Paeoniae Rubra and Semen Ziziphi Spinosae (parched) decoct with water and the medicine residues of Radix Ginseng after extract component d filters, be condensed into after mixing.

The invention also discloses containing above-mentioned Chinese medicine composition as the pharmaceutical preparation of active component is capsule, tablet, granule, powder, oral liquid or pill.

In Chinese medicine composition of the present invention, as the latin name of the crude drug of active component and processing method thereof from " Chinese medicine voluminous dictionary " (in July, 1977, the first edition, Shanghai science tech publishing house) and " Chinese Pharmacopoeia " (version in 2005, Chemical Industry Press).

Chinese medicine composition of the present invention can also extraction routinely and preparation process, such as, the preparation technology that Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) records, make the acceptable any conventional dosage form of pharmaceutics, such as capsule, tablet, granule, powder, oral liquid or pill etc.

In application of the present invention, described Chinese medicine composition is capsule, tablet, granule, powder, oral liquid or pill, realize for enabling above-mentioned dosage form, the acceptable adjuvant of pharmacy need be added, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc. when preparing these dosage forms.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.

Capsule of the present invention is made preferably by following preparation method: cleaned by the five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra, oven drying at low temperature, for subsequent use; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, medicinal residues and aqueous solution for subsequent use; Radix Ginseng 70% alcohol heating reflux extracts secondary, 3 hours first times, second time 2 hours, and merge extractive liquid, reclaims ethanol extremely without alcohol taste; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (parched), decoct with water secondary, 3 hours first times, second time 2 hours, collecting decoction, filter, it is 1.20-1.25(60 DEG C that filtrate is concentrated into relative density) clear paste, add above-mentioned panaxynol extract, mixing, cold drying, is ground into fine powder; The five tastes such as Olibanum (processed) and Hirudo are ground into fine powder altogether; Borneolum Syntheticum porphyrize, respectively with above-mentioned fine powder facing-up, mixing, sprays into volatile oil, and mixing, incapsulates, to obtain final product.

Or capsule of the present invention is made preferably by following preparation method:

A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 100 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after Aqueous extracts filters, and one-tenth extractum to be concentrated; After Radix Ginseng ethanol extraction, then use water extraction, alcohol extract is condensed into alcohol-extracted extract after reclaiming ethanol, and Aqueous extracts is condensed into the water extracted immersing paste after filtering and mixing with all Aqueous extracts;

D) preparation process:

In Fluidbedgranulatingdrier, add superfine powder flour, then step c) gained extraction extractum is sprayed into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make capsule.

Or capsule of the present invention is made preferably by following preparation method:

A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 100 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after Aqueous extracts filters, and one-tenth extractum to be concentrated; After Radix Ginseng ethanol extraction, then use water extraction, alcohol extract is condensed into alcohol-extracted extract after reclaiming ethanol, and Aqueous extracts is condensed into the water extracted immersing paste after filtering and mixing with all Aqueous extracts, and extractum Direct spraying is dried to spray powder;

D) preparation process:

By superfine powder flour and step c) be added in Fluidbedgranulatingdrier together with gained spray drying powder, then spray solvent and make granule; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make capsule.

The consumption of pharmaceutical composition of the present invention, is converted to the weight of raw medicinal material, is each 0.8-3 gram, daily 2-4 time, is preferably each 1.11-2.22 gram, daily three times.

For the prevention and therapy effect of proved invention medicine, inventor uses the medicine (hereinafter referred to as medicine of the present invention) prepared according to the method for embodiment 1 to carry out following clinical experiment:

1 data and method

The all patients of 1.1 clinical data are the acute CO poisoning patient that Hebei Yi Ling hospital accepts for medical treatment during year December of in June, 2006 ~ 2010.According to the sings and symptoms of the central nervous system damage of the higher CO contact history of suction, acute attack, according to National Diagnostic Criteria " diagnostic criteria of management of occupational acute carbon monoxide poisoning " [People's Republic of China's standard. management of occupational acute carbon monoxide poisoning diagnostic criteria GBZ23-2002. Beijing, China Standards Press: on April 8th, 2002 issue] make acute CO poisoning diagnosis.When being admitted to hospital, patient all has and goes into a coma in various degree, and by being admitted to hospital, order numbering is divided into treatment group and matched group at random.Treatment group 45 example, wherein male 21 example, women 24 example, at 14 ~ 70 years old age, average 58.3 years old, has basic patient 13 example, wherein hypertension 4 example, diabetes 3 example, pulmonary heart disease 3 example, emphysema 2 example, Experience in Treating 1 Cases of Chronic Bronchitis.Matched group 45 example, wherein male 24 example, women 21 example, at 16 ~ 74 years old age, average 60.1 years old, has basic patient 11 example, wherein hypertension 3 example, diabetes 4 example, pulmonary heart disease 1 example, emphysema 2 example, Experience in Treating 1 Cases of Chronic Bronchitis.Two groups of patient ages, sex, severity extent no significant difference difference (P>0. 05), have comparability.The person that made a definite diagnosis Delayed Encephalopathy Caused when being admitted to hospital is not as the object of observation.

The diagnostic criteria of 1.2 Delayed Encephalopathy Causeds [Chen Shuge. the diagnosis and treatment [J] of delayed encephalopathy induced by acute carbon monoxide poisoning. Chinese Clinical doctor, 2002, after 30(8): 42-43] disturbance of consciousness recovers, through " latent phase " of about 2 ~ 60 days, there is again the one of following clinical performance: (1) spirit and disturbance of consciousness are dull-witted state, delirium or decerebrate cortex state; (2), there is the performance of parkinson's syndrome in extrapyramidal system delayed ischemic neurological deficits; (3) pyramidal system nervous lesion, as hemiplegia, the pathologic reflex positive or urinary incontinence; (4), as aphasia, insomnia, or there is secondary epilepsy in due to cerebral cortex focal dysfunction.

The Primary Cares such as 1.3 Therapeutic Method the control group citicoline, piracetam, adenosine triphosphate, vitamin C, dexamethasone, after wherein dexamethasone applies 7 days, decrement is to stopping using.Treatment group adds medicine of the present invention on matched group basis, 2 tablets/time, 3 times/day, is 20 days the course for the treatment of.In addition, two groups of cases all carry out hyperbaric oxygentherapy, and treatment pressure is 0.2MPa, boosting 20min, voltage stabilizing oxygen uptake 60min, decompression 40min, and every day 1 time 10 days was 1 course for the treatment of, had a rest 2 ~ 3 days between per course for the treatment of, treated 20 days altogether.Two groups of patient base treatment and basic nursing identical, have the infected to add with antibiotic, the obvious person of cerebral edema adds with dehydrant, and other are without special treatment.

1.4 observation index observe the therapeutic effect, the incidence rate of Delayed Encephalopathy Caused, dead number of cases, untoward reaction etc. of two groups of patients.

1.5 efficacy assessment standards [Sun Chuanxing edits. and clinical disease diagnosis is according to curing improvement standard [M]. and the 2nd edition. Beijing, People's Medical Officer Press: 2002:143] recovery from illness: the clear language profit of god, extremity activity can, impassivity system location sign, observe February without recurrence; Effective: the clear language profit of god, extremity activity can, impassivity system location sign, but occasionally have dizziness, headache, weak, observes February without recurrence; Invalid: the clinical manifestation of Delayed Encephalopathy Caused sequela appears in patient.

1.6 statistical methods adopt Ridit assay therapeutic effect, compare employing X 2 test between two groups of rates.

2 results

2.1 comparitive study matched group 45 examples, recovery from illness 15 example, effective 22 examples, invalid 8 examples, total effective rate is 82.2%; Treatment group 45 example, recovery from illness 24 example, effective 19 examples, invalid 2 examples, total effective rate is 95.6%.Two groups of therapeutic effect are analyzed through Ridit, U=2.208, P=0.027, and treatment group is obviously better than matched group (P<0.05), there is significant difference.The results are shown in Table 1.

Table 1 a liang group patient outcomes compare

Group	Number of cases	Recovery from illness	Effective	Invalid	Total effective rate %
						Matched group	45	15	22	8	82.2
Treatment group	45	24	19	2	95.6

2.2 Delayed Encephalopathy Caused incidence rate matched group Late-onset encephalopathy 8 examples, incidence rate is 17.8%, and treatment group 2 example, incidence rate is 4.4%, and through X 2 test, the incidence rate for the treatment of group Delayed Encephalopathy Caused is starkly lower than matched group (P<0.05).

2.3 deaths and untoward reaction: matched group 2 cases died, treatment group has no death.Two groups all do not find obvious liver, kidney toxic and side effects and dysfunction of blood coagulation.

Take a broad view of this result of study, treatment group curative effect is obviously better than matched group, Delayed Encephalopathy Caused incidence rate significantly reduces, chemoprophylaxis of the present invention and treatment carbon monoxide poisoning encephalopathy determined curative effect are described, obviously can reduce the secondary lesion that cerebral anoxia causes, thus effectively reduce the generation of Delayed Encephalopathy Caused, improve the life quality of therapeutic efficiency and patient, embody characteristic and the advantage of Chinese medicine " preventive treatment of disease ".Chinese medicine composition of the present invention uses traditional Chinese medical science veins disease theories, according to the Therapeutic Principle of " network to lead to for ", selects QI invigorating and insects dredging collateral medicine to be lead to develop Chinese medicine preparation, the party selects the Scorpio of expel wind to dredge collateral, Scolopendra, Periostracum Cicadae, reject the Hirudo of the network stasis of blood, Eupolyphaga Seu Steleophaga, Lignum Dalbergiae Odoriferae, the Olibanum of happy network gas, the logical Radix Ginseng mending network void, all medicines match QI invigorating righting to consolidate void, dredging collateral is invigorated blood circulation evil with toxic removing, makes in healthy energy deposits, the prosperous blood of gas, and evil in residence place, venation is from logical.This Chinese medicine composition energy anticoagulant and thrombosis, promote vascular endothelial growth factor expression, improve cerebrovascular microcirculation obstacle, alleviate cerebral tissue edema, reduce central excitatory amino acid content, improve the oxygen uptake capacity of brain cell, antagonism oxygen free radical injury, alleviate the inflammatory reaction of ischemic tissue of brain, increase brain regional blood flow, suppress the apoptosis of vascular endothelial cell that anoxia causes, promote the revascularization after brain injury, the performance synergism of multipath multi-angle, thus reach the effect of prevention and therapy Delayed Encephalopathy Caused.

Detailed description of the invention

Embodiment 1:

A) crude drug formula is:

Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (processed) 13.2g

Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (parched) 33g;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 30-40 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, it is 0.9 ~ 1.1 (60 DEG C) alcohol-extracted extract that alcohol extract is condensed into relative density, and Aqueous extracts is concentrated into the clear paste that relative density is 0.9 ~ 1.1 (60 DEG C) after filtering and mixing with above-mentioned all Aqueous extracts, for subsequent use;

D) preparation process:

In Fluidbedgranulatingdrier, add superfine powder flour, then step c) gained extraction extractum is sprayed into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make 1000 capsules.

The consumption of medicine of the present invention is each 2-4 grain, daily three times.

Embodiment 2

A) crude drug formula is:

Radix Ginseng 66g Hirudo 52.8g Eupolyphaga Seu Steleophaga 46.2g Olibanum (processed) 13.2g

Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 59.4g

Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (parched) 33g

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 70-90 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, alcohol extract is condensed into relative density and is determined as 1.0 ~ 1.05 alcohol-extracted extracts at 60 DEG C, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 1.0 ~ 1.1, for subsequent use;

D) preparation process:

Superfine powder flour is added, then by step c in Fluidbedgranulatingdrier) gained extracts extractum and sprays into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, preparation process is pressed into 1000 routinely.

The consumption of medicine of the present invention is each 2-4 sheet, daily three times.

embodiment 3: the preparation of pill

A) crude drug formula is:

Radix Ginseng 39.6g Hirudo 66g Eupolyphaga Seu Steleophaga 46.2g Olibanum (processed) 13.2g

Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 46.2g

Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (parched) 33g

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter 10-20 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, it is 0.9 ~ 1.0 alcohol-extracted extract that alcohol extract is condensed into 60 DEG C of mensuration relative densities, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 1.0 ~ 1.1, for subsequent use;

D) preparation process:

Preparation process routinely, makes 1000 pills.

The consumption of medicine of the present invention is each 2-4 grain, daily three times.

Claims (5)

1. the application of Chinese medicine composition in the medicine preparing prevention and therapy delayed encephalopathy after acute carbon monoxide poisoning, is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (processed) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5 Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (parched) 3-10, the active component of described Chinese medicine composition is made up of following ingredients:

A mean diameter be less than 100 μm Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and Olibanum (processed) medicated powder;

B Borneolum Syntheticum medicated powder;

The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;

The alcohol-extracted extract of alcohol extract after d Radix Ginseng ethanol extraction after concentrated;

The water extracted immersing paste that the Aqueous extracts of the Aqueous extracts after the Aqueous extracts of the Lignum Dalbergiae Odoriferae after e extract component c and Lignum Santali Albi medicinal residues, Radix Paeoniae Rubra and Semen Ziziphi Spinosae (parched) decoct with water and the medicine residues of Radix Ginseng after extract component d filters, be condensed into after mixing.

2. apply as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophaga 7 Olibanum (processed) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 7 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched) 5.

3. apply as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophaga 7 Olibanum (processed) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 9 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched) 5.

4. apply as claimed in claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophaga 7 Olibanum (processed) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 3 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched) 5.

5. the application according to any one of claim 1-4, is characterized in that, this Chinese medicine composition is capsule, tablet, granule, powder or pill as the pharmaceutical preparation of active component.