CN101439116B - Use of Chinese medicinal composition in preparing medicament for treating diabetes mellitus induced erectile dysfunction - Google Patents
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Abstract
The invention discloses the application of a traditional Chinese medicine composition in preparing a medicine for DMED. The traditional Chinese medicine has the efficacy of qi-invigorating and blood-activation and expelling wind to dredge collateral, and can effectively treat DMED clinically.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment diabetic erectile dysfunction medicine, belong to the Chinese medicine application.
Background technology
Erection disturbance (erectile dysfunction, ED) be one of the common complication of type 2 diabetes mellitus, the survey result of China's type 2 diabetes mellitus erection disturbance multicenter investigation cooperative groups shows that the prevalence of diabetics erection disturbance is 75.2%, diabetic duration is investigated the curative effect and the safety evaluatio of cooperative groups .2 diabetes mellitus type erection disturbance prevalence and sldenafil up to 91.3%[China type 2 diabetes mellitus erection disturbance multicenter greater than the prevalence of the patient's erection disturbance in 10 years. Chinese endocrine metabolism magazine, 2005,21 (4): 348-352.].The erection disturbance of diabetes than other crowd's onset early, the prevalence height is compared the attention that does not cause that numerous doctors are enough with other diabetic complication, the patient is also treated seldom fully, has a strong impact on patient's quality of life.
Diabetic erectile dysfunction is the organic disease [Bi Huimin of erection function, Deng Xiangqun, Zhang Jianli. the effect of the improvement of function of nervous system in the treatment of diabetic erection problem. Chinese andrology magazine, 2004,18 (1): 26-28.], very high sickness rate is arranged at diabetics.Generally believe at present disorders such as blood vessel, nerve, hormone, endothelial function be diabetic erectile dysfunction main diseases because of.Because the own characteristic of diabetes, diabetics exist in various degree vascular lesion (comprising trunk, microangiopathies), neuropathy mostly, make that the treatment of diabetic erectile dysfunction is comparatively difficult.Vascular lesion is the leading factor of thinking at present that causes diabetic erectile dysfunction.Erection is the angioplerosis process under innervation, be that spinal cord breast waist section sympathetic nerve suppresses and the excitement of lumbosacral segment parasympathetic nervous, thereby influence the non-adrenal gland/non-cholinergic nerve of cavernous body of penis, discharge neurotransmitter, cause the vascular smooth muscle diastole based on NO.In whole erection process, function of nervous system plays " trigger " effect, and delayed ischemic neurological deficits must influence the start-up course of erection.Abroad studies show that, neuropathy is the principal element that causes Erectile Dysfunction, and motor nerve conduction velocity can roughly reflect the functional status of nervous tissue, though can not be used for the diagnosing diabetes erectile dysfunction, can be used to assess the function of nervous system of Erectile Dysfunction.Therefore, select for use the conduction velocity of mensuration common peroneal nerve and tibial nerve as the index of estimating Erectile Dysfunction function of nervous system usually.
Traditional medicine thinks, the generation and the blood stasis of diabetes multiple complications closely related [Zhou Zhongying. Chinese Internal Medicine. the 7th edition. Beijing: China Traditional Chinese Medicine Publishing House, 2003.427-433.].According to traditional Chinese medical science network ens morbi, pathogen usually intruding into collateral in protracted disease, the many stasis of bloods of prolonged illness, for a long time the stasis of blood is gone into network, diabetic erectile dysfunction belong to the sick category of network [Wu Yiling. network is sick to be learned. the 1st edition. Beijing: China Science Tech Publishing House, 2004.30-34.].Medicine of the present invention is representative side's medicine of network ens morbi, is made up of Radix Ginseng, Hirudo, Scorpio, Eupolyphaga Seu Steleophaga, Scolopendra, Radix Paeoniae Rubra, Borneolum Syntheticum, Semen Ziziphi Spinosae etc., has the effect of benefiting QI for activating blood circulation, expel wind to dredge collateral.Show that by clinical research medicine of the present invention can effectively be treated diabetic erectile dysfunction.
The present invention is the improvement invention of carrying out on the basis of No. 01131203.3 Chinese patent and No. 200410048292.2 patent, quotes in full the content of this two patent documents record at this.The invention provides the application of a kind of Chinese medicine composition in preparation treatment diabetic erectile dysfunction medicine,, can treat diabetic erectile dysfunction effectively by benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral.
Summary of the invention
The object of the invention provides the application of a kind of Chinese medicine composition in preparation treatment diabetic erectile dysfunction medicine, and described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10;
Preferably, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5; Or:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
More preferably, the active component of Chinese medicine composition of the present invention is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
In the Chinese medicine composition of the present invention, the latin name of raw medicinal material and processing method thereof are from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2005, Chemical Industry Press).
In the application of the present invention, one or more in each raw material of described Chinese medicine composition can be replaced by the raw material of Chinese medicine medicine of the identical property of medicine, effect individually or simultaneously, and after the replacement, composite preparation and effect do not change.
Chinese medicinal composition preparation of the present invention can also be routinely preparation process, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, for example capsule, tablet, pill, oral liquid, soft capsule, drop pill etc.
In the application of the present invention, described Chinese medicine composition is a kind of in capsule, tablet, pill, oral liquid, soft capsule, the dropping pill formulation, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Preparation of the present invention is preferably made by following preparation method: five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra cleaned, and oven drying at low temperature, standby; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, and medicinal residues and aqueous solution are standby; Radix Ginseng extracts secondary with 70% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 ℃), add above-mentioned panaxynol extract, mixing, cold drying is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; The Borneolum Syntheticum porphyrize, with above-mentioned fine powder facing-up, mixing sprays into volatile oil respectively, and mixing incapsulates, promptly.
Perhaps, preparation of the present invention is preferably made by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Perhaps, preparation of the present invention is preferably made by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (system) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
During the present invention used, the consumption of the present composition by the crude drug gross weight, was each 0.8-3 gram, and take 2-4 every day, is preferably each 1.11-2.22 gram, takes every day three times.
The specific embodiment
Embodiment 1: the preparation of medicine of the present invention
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge decocting liquid, after the water extract filters, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, it is 0.9～1.1 (60 ℃) alcohol-extracted extract that alcohol extract is condensed into relative density, is concentrated into the clear paste that relative density is 0.9～1.1 (60 ℃) behind the filtration of water extract and above-mentioned all water extract mixings, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules behind the mixing.
Usage and consumption: oral.One time 2～4,3 times on the one.
For illustrating the new application of medicine of the present invention, use the capsule 's content (to call medicine of the present invention in the following text) that makes by embodiment 1 method to carry out following clinical trial.
The experiment of experimental example medicine of the present invention (according to the preparation of embodiment 1 method) treatment diabetic erectile dysfunction
1 data and method
1.1 the selected altogether 60 routine patients of this problem of physical data, test group 40 examples, matched group 20 examples.Duration of test lose to be visited 4 examples, test group 2 examples wherein, matched group 2 examples.Lose and visit case by invalidation.Year at bulk test group age (50.21 ± 10.32); Diabetic duration (7.85 ± 3.61) year, the erection disturbance course of disease (3.23 ± 2.30) year; Year at matched group age (49.96 ± 10.67); Diabetic duration (7.69 ± 3.55) year, the erection disturbance course of disease (3.18 ± 2.53) year.2 groups at aspects such as age, diabetic duration and the erection disturbance courses of disease relatively, and difference not statistically significant (P＞0.05) has comparability.
1.2 case is selected inclusion criteria: (1) married male's type 2 diabetes mellitus patient, the clinical diagnosis erection disturbance and the course of disease are more than 3 months; (2) international erection function scoring (IIEF-5)≤21 minute; (3) fasting glucose control in selected preceding 1 month is stable, and below 8.0mmol/L; (4) voluntary accepting is treated and can be cooperated and follows up a case by regular visits to and the examiner.Exclusion standard: the edeotomy deformity (as serious penis fibrosis) that (1) patient has obvious damage to erect; (2) patient has other sexual function unusual (low as libido), and is considered to primary diagnosis; (3) patient has serious psychological abnormality to influence clinical observation; (4) known patient has alcoholism or drug dependence history before this in 12 months; (5) patient has serious cardiovascular and cerebrovascular vessel, blood, nephropathy or hepatic disease history; (6) patient has hypotension or hypertension more than 2 grades is arranged; (7) patient is taking androgen, Trazodone, nitrate esters or nitric oxide donors at present; (8) patient with treatment erection disturbance (comprising testosterone), and does not prepare to interrupt the above-mentioned practice with injection, per urethra administration or other drug or therapy in the vacuum suction device, spongy body in the clinical observation process; (9) patient once accepted the research medicine of treatment erection disturbance in the past within 3 months.
1.3 Therapeutic Method adopts at random, double blinding, placebo parallel check experiment method for designing.By test group: matched group is design in 2: 1, according to the prescription on individual diagnosis order patient's random assortment to medicine of the present invention (each 3, every day 3 times) group and placebo (each 3, every day 3 times) is organized 3 months courses of treatment.
1.4 the international erection function scoring of curative effect index (1) (IIEF-5); (2) common peroneal nerve motor conduction velocity (PNCV) and tibial nerve motor conduction velocity (TNCV); (3) fasting glucose (FPG), glycolated hemoglobin (HbA
1C).Detect respectively at before the test and test back.
1.5 the statistical procedures measurement data is used
Expression, enumeration data represent that with frequency and percentage ratio all statistical analysiss adopt SPSS13.0 software to carry out.
2 results
2.1 international erection function scoring (IIEF-5) treatment preceding two groups of patient IIEF-5 comparing difference not statistically significants (P＞0.05).After the medication 3 months, comparing difference has statistical significance (P＜0.01) before and after the test group treatment, comparing difference not statistically significant (P＞0.05) before and after the treatment of control group; Two groups of difference comparing differences have statistical significance (P＜0.01), and the test group curative effect is better than matched group.See Table 1.
The table 1 liang international erection function scoring of group (IIEF-5) is analyzed
Annotate: compare P＜0.01 before and after the △ △ treatment, * * and matched group be P＜0.01 relatively.
2.2 nerve conduction velocity analysis preceding two groups of patient PNCV of treatment and the equal not statistically significant of TNCV comparing difference (P＞0.05).After the medication 3 months, comparing difference all has statistical significance (P＜0.05) before and after the test group treatment, the equal not statistically significant of comparing difference (P＞0.05) before and after the treatment of control group; Two groups of difference comparing differences all have statistical significance (P＜0.05), and the test group curative effect is better than matched group.See Table 2-3.
Table 2 a liang group common peroneal nerve motor conduction velocity (PNCV) is analyzed
Annotate: compare P＜0.05 before and after the △ treatment, * and matched group be P＜0.05 relatively.
Table 3 a liang group tibial nerve motor conduction velocity (TNCV) is analyzed
Annotate: compare P＜0.05 before and after the △ treatment, * and matched group be P＜0.05 relatively.
2.3 fasting glucose and glycolated hemoglobin analysis preceding two groups of patient FPG of treatment and HbA
1The equal not statistically significant of C comparing difference (P＞0.05).After the medication 3 months, the equal not statistically significant of comparing difference (P＞0.05) before and after two groups of treatments; Two groups of difference test group have the matched group of being better than to get trend, because the less statistical significance (P＞0.05) that do not occur of sample size.See Table 4-5.
Table 4 liang group (FPG) is on an empty stomach analyzed
Annotate: compare P＜0.05 before and after the △ treatment, * and matched group be P＜0.05 relatively.
Table 5 liang group glycolated hemoglobin (HbA
1C) analyze
Annotate: compare P＜0.05 before and after the △ treatment, * and matched group be P＜0.05 relatively.
3. conclusion
Show that by above clinical research medicine of the present invention can obviously improve diabetic erectile dysfunction patient IIEF-5, PNCV and TNCV, simultaneously to the FPG and the HbA of diabetics
1C also has some improvement.Therefore, medicine of the present invention can be treated diabetic erectile dysfunction effectively.
Claims (7)
1. the application of Chinese medicine composition in preparation treatment diabetic erectile dysfunction medicine is characterized in that this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (processed) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (parched) 3-10.
2. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudos 10 Eupolyphaga Seu Steleophagas 7 Olibanum (processed)s 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched)s 5.
3. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 10 Hirudos 8 Eupolyphaga Seu Steleophagas 7 Olibanum (processed)s 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched)s 5.
4. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudos 11 Eupolyphaga Seu Steleophagas 7 Olibanum (processed)s 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched)s 5.
5. as each described application among the claim 1-4, it is characterized in that the active component of described Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
6. as each described application of claim 1-4, it is characterized in that the preparation formulation of described Chinese medicine composition is capsule, tablet, pill or oral liquid.
7. application as claimed in claim 5 is characterized in that, the preparation formulation of described Chinese medicine composition is capsule, tablet, pill or oral liquid.
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| CN104922202A (en) * | 2015-03-18 | 2015-09-23 | 江苏丰颂生物科技有限公司 | Composition for treating diabetes erectile dysfunction and preparation method thereof |
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| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1709291A (en) * | 2004-06-18 | 2005-12-21 | 河北以岭医药研究院有限公司 | Supermicro heart-meridians-activating Chinese medicine composition and its preparing method |
| CN1836712A (en) * | 2005-03-25 | 2006-09-27 | 重庆大易科技投资有限公司 | Pharmaceutical composition for treating sexual disorder and its preparation process |
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| CN104922202A (en) * | 2015-03-18 | 2015-09-23 | 江苏丰颂生物科技有限公司 | Composition for treating diabetes erectile dysfunction and preparation method thereof |
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