CN101269142B - Application of Chinese medicinal composition in preparing medicament for treating right bundle branch conduction block - Google Patents
Application of Chinese medicinal composition in preparing medicament for treating right bundle branch conduction block Download PDFInfo
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Abstract
The invention discloses an application of a traditional Chinese medicine composition in the preparation of a drug for curing right bundle branch block. The traditional Chinese medicine composition can effectively cure complete right bundle branch block by invigorating Qi, activating blood, dissolving stasis and freeing channel.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in preparation treatment complete right bundle branch block medicine, belong to the Chinese medicine application.
Background technology
Complete right bundle branch block is meant the right bundle branch generation conduction block in the ventricle conducting system, belongs to a kind of of intraventricular conductional block.Right bundle branch block (Right Bundle Branch Block, hereinafter to be referred as RBBB) comprise complete right bundle branch block (Complete Right Bundle BranchBlock, hereinafter to be referred as CRBBB) and incomplete right bundle-branch block (Incomplete RightBundle Branch Block is hereinafter to be referred as IRBBB).Generally speaking, the relative left bundle branch of right bundle branch is elongated, therefore is easy to take place conduction block.
Complete right bundle branch block often can cause serious consequence, serious harm people's life and cause people's attention.Right bundle branch block is clinical common electrocardiographic abnormality, and epidemiologic data shows that the generation of right bundle branch block increased with the age, and different age group incidence rates is different, and incidence rate is 1% in the time of 50 years old, and incidence rate is 17% during by 80 years old.Someone passes through research, detects incomplete right bundle-branch block patient 377 examples (3.59%) in 10477 people's health check-up crowd, detects complete right bundle branch block patient 142 examples (1.35%); Have the simple follow-up investigation in 30 years of right bundle branch block patient of 855 examples is thought: right bundle branch block and age are strong correlation, comparatively general in the old people, their simple right bundle branch block of research conclusion support is a right bundle branch degeneration that slowly takes place; The right bundle branch block patient who has the people that 70 examples are taken place recently again on average followed up a case by regular visits to 18 years after having got rid of tangible cardiovascular disease, the cardiovascular death rate is greater than 3 times of matched groups, especially when QRS interval 〉=130ms, cardiac electric axis easier generation Cardiovascular abnormality between-45 °～-90 °.These all are the common clinical characters of right bundle branch block.(Xu Qin, Wang Fengdi. the Clinical features of right bundle branch block. Chinese current clinical medicine magazine 2005,3 (4))
Complete right bundle branch block is clinical comparatively common cardiac arrhythmia, except that seeing various heart diseases, also sees the normal person.The ARR Western medicine of treatment all has untoward reaction in various degree at present, and itself also has arrhythogenic effect.
The present invention is the improvement invention of carrying out on the basis of No. 01131203.3 Chinese patent and No. 200410048292.2 patent, quotes in full the content of this two patent documents record at this.The invention provides the application of a kind of Chinese medicine composition in preparation treatment complete right bundle branch block medicine.Chinese medicine composition of the present invention can be treated complete right bundle branch block effectively by benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral.
Summary of the invention
The object of the invention provides the application of a kind of Chinese medicine composition in preparation treatment right bundle branch block medicine, and described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10;
Preferably, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
More preferably, the active component of Chinese medicine composition of the present invention is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
In the Chinese medicine composition of the present invention, the latin name of raw medicinal material and processing method thereof are from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2005, Chemical Industry Press).
In the application of the present invention, one or more in each raw material of described Chinese medicine composition can be replaced by the raw material of Chinese medicine medicine of the identical property of medicine, effect individually or simultaneously, and after the replacement, composite preparation and effect do not change.
Chinese medicinal composition preparation of the present invention can also be routinely preparation process, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, for example capsule, tablet, pill, oral liquid, soft capsule, drop pill etc.
In the application of the present invention, described Chinese medicine composition is a kind of in capsule, tablet, pill, oral liquid, soft capsule, the dropping pill formulation, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Preparation of the present invention is preferably made by following preparation method: five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra cleaned, and oven drying at low temperature, standby; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, and medicinal residues and aqueous solution are standby; Radix Ginseng extracts secondary with 70% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 ℃), add above-mentioned panaxynol extract, mixing, cold drying is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; The Borneolum Syntheticum porphyrize, with above-mentioned fine powder facing-up, mixing sprays into volatile oil respectively, and mixing incapsulates, promptly.
Perhaps, preparation of the present invention is preferably made by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Perhaps, preparation of the present invention is preferably made by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (system) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
More preferably, medicine of the present invention can be treated complete right bundle branch block effectively by benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral.
During the present invention used, the consumption of the present composition by the crude drug gross weight, was each 0.8-3 gram, and take 2-4 every day, is preferably each 1.11-2.22 gram, takes every day three times.
The specific embodiment
Embodiment 1: the preparation of medicine of the present invention
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge decocting liquid, after the water extract filters, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, it is 0.9～1.1 (60 ℃) alcohol-extracted extract that alcohol extract is condensed into relative density, is concentrated into the clear paste that relative density is 0.9～1.1 (60 ℃) behind the filtration of water extract and above-mentioned all water extract mixings, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules behind the mixing.
Usage and consumption: oral.One time 2～4,3 times on the one.
For illustrating the new application of medicine of the present invention, use the capsule 's content dry powder (to call medicine of the present invention in the following text) that makes by embodiment 1 method to carry out following animal experiment.
Experimental example medicine of the present invention (according to the preparation of embodiment 1 method) treatment complete right bundle branch block
Experiment
1, data and method
1.1 clinical data
1.1.1 physical data selects navigate very much complete right bundle branch block patient 64 examples of hospital admission of Taiyuan City in year October, in May, 2005～2006 to be divided into treatment at random and to organize 34 examples (women's 19 examples, male's 15 examples), 47.52 ± 11.90 years old mean age, the course of disease 5 months～2 years, average 1 year 2 months; Matched group 30 examples (women's 17 examples, male's 13 examples), 48.56 ± 12.60 years old mean age, the course of disease 6 months～2 years, average 1 year 2 months.Simple complete right bundle branch block 12 examples of property merge coronary heart disease 7 examples, pulmonary heart disease 13 examples, hypertension 2 examples in the wherein treatment group; Simple complete right bundle branch block 15 examples of property merge coronary heart disease 5 examples, pulmonary heart disease 8 examples, hypertension 2 examples in the matched group.Baseline data comparing difference not statistically significant (P＜0.05) between two groups of patients.
1.1.2 diagnostic criteria: right bundle branch block diagnostic criteria: (1) sinus rhythm; (2) V1, V2 are the rSR type; (3) I, V5, V6 lead the S ripple; (4) P-R interval〉0.12s; (5) QRS ripple 〉=0.12s.
Traditional Chinese medical science disease and syndrome diagnostic criteria meet the cardiopalmus disease with reference to " People's Republic of China's Chinese medicine industry standard---tcm diagnosis standard 1994 ", and card belongs to the syndrome of blood stasis due to qi deficiency patient.
1.1.3 the standard of including in: meet above-mentioned diagnostic criteria and heart rate＜40 time/minute, symptom significantly and can cooperate and finishes the experimenter.
1.1.4 exclusion standard: (1) age＜18 year old or 70 years old; (2) women of gestation or age of sucking; (3) person that has the Adams Stokes syndrome; (4) serious primary disease such as Liver and kidney and hemopoietic system; (5) psychotic.
1.1.5 termination test, the case that comes off and reject case and processing: answer termination test when adverse events such as primary disease and the deterioration of carrying out property of arrhythmia, AMI, sudden death taking place in the treatment and needing the adverse effect of drug withdrawal.The adverse events case takes place charge to the observation case by invalid case.The adverse effect person is taken place to take medicine above charging to total case 2 weeks and adding up curative effect; Do not surpass and be included into the rejecting case when two all persons sum up.All stop case and all do safety analysis.
The patient is unwilling to continue to take medicine or is the case that comes off because of the uncooperative case of visiting of losing.Should analyze come off reason and treatment has irrelevantly, and does safety analysis as far as possible.When case summary and analysis, to not meeting inclusion criteria, can not analyzing curative effect person for rejecting case by the rule of operation observation.
1.2 treatment and observational technique
1.2.1 method of administration: matched group gives 5～10 milligrams of isoproterenol (Li Nuoke peak, Shandong pharmaceutical Co. Ltd), sublingual administration, per 2～6 hours 1 time (the control heart rate is about 60 times/minute); The oral on this basis medicine of the present invention of treatment group (Yiling Pharmaceutical Co., Ltd, Shijiazhuang's production), every day 3 times, obeyed for 4 weeks altogether by each 4.Observed content: observe tcm syndrome situations such as the conscious uneasiness in the heart of patient, shortness of breath and fatigue, uncomfortable in chest, look asthenia, picture of the tongue, pulse condition; Check electrocardiogram weekly 1 time before the treatment and after taking medicine; Blood, urine, just conventional before and after the treatment; Liver, renal function projects such as (ALT, BUN, Cr) detect.
1.2.2 comprehensive therapeutic effect criterion: judge according to the criterion of therapeutical effect that nineteen ninety-five Ministry of Public Health promulgation " the clinical research guideline of new Chinese medicine treatment cardiopalmus " and combination of Chinese and Western medicine meeting are formulated.Produce effects: patient's transference cure or obviously alleviate; Electrocardiogram returns to normal person's level or normal substantially.Effectively: patient's symptom partly alleviates, and electrocardiogram is near normal level.Invalid: patient's sx is not obvious or increase the weight of, and ECG change is not obvious.
1.2.3 the statistical analysis statistical software adopts SPSS10.0, curative effect relatively adopts the Wilcoxon rank test between two groups, and total effective rate relatively adopts X
2Check.There is statistical significance P＜0.05 for difference.
2, the results are shown in Table 1.
The two groups of curative effects in table 1 treatment back relatively
| Group | n | Produce effects | Effectively | Invalid | Total effective rate |
| Treatment group matched group | 3430 | 25(73.5％)12(40.0％) | 6(17.7％)9(30.0％) | 3(8.8％)?9(30.0％) | 91.2％ *70.0％? |
Annotate: compare with matched group,
*P＜0.05
Treatment group check blood, urine, just conventional; Relatively do not have significant change before liver, renal function etc. and the medication, do not find untoward reaction.
3. discuss
Atrioventricular block is because functional or organic disease takes place for the conducting system of heart, and normal electrocardio conduction can not be by reaching under the atrium due to the ventricle.Complete right bundle branch block is clinical comparatively common cardiac arrhythmia, and treating ARR Western medicine at present all has in various degree untoward reaction, and itself also has arrhythogenic effect.Arrhythmia belongs to categories such as the traditional Chinese medical science " cardiopalmus ", " palpitation with a distress feeling ".Medicine of the present invention is made up of medicines such as Radix Ginseng, Hirudo, Scorpio, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae, Radix Paeoniae Rubra and Borneolum Syntheticums as the traditional Chinese medical science network ens morbi side of representative, has the effect of benefiting QI for activating blood circulation, disperse blood stasis and dredge collateral, can effectively treat complete right bundle branch block.
4. conclusion
After using Drug therapy of the present invention, patient's clinical symptoms and electrocardiogram situation are obviously improved, and total effective rate is apparently higher than matched group, and do not have tangible untoward reaction and side effect.Thereby medicine of the present invention can be treated complete right bundle branch block effectively.
Claims (8)
1. the application of Chinese medicine composition in the medicine of preparation treatment right bundle branch block is characterized in that this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (processed) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (parched) 3-10.
2. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudos 10 Eupolyphaga Seu Steleophagas 7 Olibanum (processed)s 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched)s 5.
3. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 10 Hirudos 8 Eupolyphaga Seu Steleophagas 7 Olibanum (processed)s 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched)s 5.
4. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudos 11 Eupolyphaga Seu Steleophagas 7 Olibanum (processed)s 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (parched)s 5.
5. as each described application among the claim 1-4, it is characterized in that the active component of described Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
6. as each described application among the claim 1-4, it is characterized in that described Chinese medicine composition is capsule, tablet, pill or oral liquid as the pharmaceutical preparation of active component.
7. as each described application among the claim 1-4, it is characterized in that described right bundle branch block is a complete right bundle branch block.
8. application as claimed in claim 5 is characterized in that, described right bundle branch block is a complete right bundle branch block.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1709291A (en) * | 2004-06-18 | 2005-12-21 | 河北以岭医药研究院有限公司 | Supermicro heart-meridians-activating Chinese medicine composition and its preparing method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1709291A (en) * | 2004-06-18 | 2005-12-21 | 河北以岭医药研究院有限公司 | Supermicro heart-meridians-activating Chinese medicine composition and its preparing method |
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| Title |
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| 王天云."通心络胶囊在临床中的应用".《络病学基础与临床研究》.2006, |
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