CN101757153B - Application of traditional Chinese medicine composition in preparation of medicines for treating kidney deficiency blood stasis type erectile dysfunction - Google Patents

Abstract

The invention discloses an application of a traditional Chinese medicine composition in the preparation of medicines for treating kidney deficiency blood stasis type erectile dysfunction. The traditional Chinese medicine composition comprises ginseng, leech, centipede, scorpio, ground beeltle, cicada slough, radix paeoniae rubra, borneol and the like, has the effects of supplementing qi and activating blood circulation as well as eliminating blood-stasis and freeing channels. Clinical tests prove that the traditional Chinese medicine composition can effectively treat the kidney deficiency blood stasis type erectile dysfunction without adverse reactions found.

Description

The application of a kind of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine

Technical field

The present invention relates to a kind of novelty teabag of Chinese medicine composition, particularly, the present invention relates to the application of a kind of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine, belong to application in TCM field.

Background technology

Erection disturbance (Erectile dysfunction, ED) refers to that penis continues to reach or to maintain to erect to meet sexual life.Chinese medicine is referred to as sexual impotence, and think, the erection of penis is by the result of the mutual coordinative role of a series of internal organs, meridians and qi-blood-body fluid, and inside and outside various pathological factor causes the imbalance or impaired of the functional activity of above-mentioned internal organs and meridians, all can produce erection disturbance.Owing to causing the factor of erection disturbance more complicated, therefore the traditional Chinese medical science is while tune liver dredging collateral, vital energy benefiting and the kidney invigorating, cautiously grasping pathogenesis, treatment according to the specific symptoms.

Society, rhythm of life is accelerated, and social pressure and operating pressure are large, and shape will is overworked, and dinner party increases, and night life is too much, so that the change of feelings will is too drastic, and kidney qi interior-deficiency causes patient to be increased, and with the passing of time blood vessels are obstructed and cause kidney deficiency blood stasis type erectile dysfunction.Under modern society's condition erection disturbance with suffer from a deficiency of the kidney the closest, with the passing of time occur that blood stasis due to renal deficiency syndrome is rather common.

The Therapeutic Method of erection disturbance comprises: 1, vasoactive agent injection for curing; 2, topical treatment; 3, oral drug therapy, mainly contains sildenafil citrate, Vardenafil hydrochloric acid and tadanafil etc.

Although western medicine erection disturbance has advantage that is rapid-action, successful, owing to acting on local, curative effect disappears also fast, and there is certain untoward reaction complication and contraindication.Treatment by Chinese herbs onset is relatively slow, but acts on whole body, and curative effect is lasting, and side effect is little, is multi-target effect, is not single effect, has good clinical efficacy.

The present invention is the improvement invention carried out on the basis of No. 01131203.3 and No. 200410048292.2 patent, quotes in full the content of this two patent document record at this.The application of above-mentioned two patents this Chinese medicine composition unexposed in treatment kidney deficiency blood stasis type erectile dysfunction.

Summary of the invention

The object of the invention is to provide the application of a kind of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine;

The present invention applies described Chinese medicine composition primarily of compositions such as Radix Ginseng, Hirudo, Scorpio, Eupolyphaga Seu Steleophaga, Scolopendra, Periostracum Cicadae, Radix Paeoniae Rubra and Borneolum Syntheticums, there is the function of benefiting QI for activating blood circulation, dredging collateral, vascular flow amount can be increased, improve blood vessel blood to supply, recover the effects such as impaired vascular endothelial function, effectively can treat kidney deficiency blood stasis type erectile dysfunction.

Described Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5

Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10;

Preferably, this Chinese medicine composition is made up of the crude drug of following weight portion:

Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophaga 7 Olibanum (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 7 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (stir-fry) 5;

Or:

Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophaga 7 Olibanum (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 9 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (stir-fry) 5;

Or:

Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophaga 7 Olibanum (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferae 2

Lignum Santali Albi 2 Scorpio 3 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosae (stir-fry) 5;

The active component of above-mentioned Chinese medicine composition is made up of following ingredients:

A mean diameter be less than 100 μm Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and Olibanum (processed) medicated powder;

B Borneolum Syntheticum medicated powder;

The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;

The alcohol-extracted extract of alcohol extract after d Radix Ginseng ethanol extraction after concentrated;

The water extracted immersing paste that the Aqueous extracts of the Aqueous extracts after the Aqueous extracts of the Lignum Dalbergiae Odoriferae after e extract component c and Lignum Santali Albi medicinal residues, Radix Paeoniae Rubra and Semen Ziziphi Spinosae (parched) decoct with water and the medicine residues of Radix Ginseng after extract component d filters, be condensed into after mixing.

The present invention applies in described Chinese medicine composition, as the latin name of the crude drug of active component and processing method thereof from " Chinese medicine voluminous dictionary " (in July, 1977, the first edition, Shanghai science tech publishing house) and " Chinese Pharmacopoeia " (version in 2005, Chemical Industry Press).

The preparation formulation that the present invention's application also discloses above-mentioned Chinese medicine composition is capsule, tablet, granule, powder, oral liquid or pill.

For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.

The present invention applies described capsule and makes preferably by following preparation method: cleaned by the five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra, oven drying at low temperature, for subsequent use; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, medicinal residues and aqueous solution for subsequent use; Radix Ginseng 70% alcohol heating reflux extracts secondary, 3 hours first times, second time 2 hours, and merge extractive liquid, reclaims ethanol extremely without alcohol taste; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours first times, second time 2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 DEG C), add above-mentioned panaxynol extract, mixing, cold drying, is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; Borneolum Syntheticum porphyrize, respectively with above-mentioned fine powder facing-up, mixing, sprays into volatile oil, and mixing, incapsulates, to obtain final product.

Or capsule is made preferably by following preparation method described in the present invention's application:

A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 100 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after Aqueous extracts filters, and one-tenth extractum to be concentrated; After Radix Ginseng ethanol extraction, then use water extraction, alcohol extract is condensed into alcohol-extracted extract after reclaiming ethanol, and Aqueous extracts is condensed into the water extracted immersing paste after filtering and mixing with all Aqueous extracts;

D) preparation process:

Superfine powder flour is added, then by step c in Fluidbedgranulatingdrier) gained extracts extractum and sprays into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make capsule.

Or capsule is made preferably by following preparation method described in the present invention's application:

A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (system) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 100 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after Aqueous extracts filters, and one-tenth extractum to be concentrated; After Radix Ginseng ethanol extraction, then use water extraction, alcohol extract is condensed into alcohol-extracted extract after reclaiming ethanol, and Aqueous extracts is condensed into the water extracted immersing paste after filtering and mixing with all Aqueous extracts, and extractum Direct spraying is dried to spray powder;

D) preparation process:

By superfine powder flour and step c) be added in Fluidbedgranulatingdrier together with gained spray drying powder, then spray solvent and make granule; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make capsule.

The present invention applies the consumption of described Chinese medicine composition, is converted to the weight of raw medicinal material, is each 0.8-3 gram, daily 2-4 time, is preferably each 1.11-2.22 gram, daily three times.

Detailed description of the invention

Embodiment 1:

A) crude drug formula is:

Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g

Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g

Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 30-40 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, it is 0.9 ~ 1.1 alcohol-extracted extract that alcohol extract is condensed into 60 DEG C of mensuration relative densities, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 0.9 ~ 1.1, for subsequent use;

D) preparation process:

Superfine powder flour is added, then by step c in Fluidbedgranulatingdrier) gained extracts extractum and sprays into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make 1000 capsules.

The consumption of medicine of the present invention is each 2-4 grain, daily three times.

Embodiment 2

A) crude drug formula is:

Radix Ginseng 66g Hirudo 52.8g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g

Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 59.4g

Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 70-90 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, alcohol extract is condensed into relative density and is determined as 1.0 ~ 1.05 alcohol-extracted extracts at 60 DEG C, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 1.0 ~ 1.1, for subsequent use;

D) preparation process:

Superfine powder flour is added, then by step c in Fluidbedgranulatingdrier) gained extracts extractum and sprays into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, preparation process is pressed into 1000 routinely.

The consumption of medicine of the present invention is each 2-4 sheet, daily three times.

Embodiment 3: the preparation of pill

A) crude drug formula is:

Radix Ginseng 39.6g Hirudo 66g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g

Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 46.2g

Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter 10-20 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol extremely without alcohol taste, use water extraction again, it is 0.9 ~ 1.0 alcohol-extracted extract that alcohol extract is condensed into 60 DEG C of mensuration relative densities, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 1.0 ~ 1.1, for subsequent use;

D) preparation process:

Preparation process routinely, makes 1000 pills.

The consumption of medicine of the present invention is each 2-4 grain, daily three times.

Experimental example:

For illustrating the curative effect of traditional Chinese medicine composition for treating kidney deficiency blood stasis type erectile dysfunction of the present invention, carried out following test to prove its curative effect with the capsule (hereinafter referred to as medicine of the present invention) obtained by above-described embodiment 1 method, but it can not form any restriction to scope of the present invention.

1 data and method

1.1 physical data

Collect the kidney deficiency blood stasis type erectile dysfunction patient that between in JIUYUE, 2005 ~ 2008 year May, Hebei Yi Ling hospital outpatient is sought medical advice, 72 routine patients all meet inclusion criteria, 23 ~ 54 years old age.Psychological 29 examples are divided into, nerve 7 example, incretion 23 example, Combination 6 example according to the erection function cause of disease.72 examples accept treatment all voluntarily.Patient is divided into treatment group and matched group at random, the routine patient for the treatment of group 36, mean age 32.6 scholar 3.4 years old; The routine patient of matched group 36, mean age 33.5 scholar 3.2 years old, two groups of patient's physical data there was no significant differences.

1.2 inclusion criteria

1. to have or without erectile ability, erection intensity is not hard, or hyposexuality.Namely some patients ejaculates less than 2min after inserting; 2. the course of disease is more than half a year, has fixing spouse, and 3. IIEF-5 scoring <20 divides; 4. period in a medicine sexual life at least one times weekly; 5. genitals and secondary sex characteristics are normally, without liver, kidney illness, without genito-urinary system inflammation and the illness that is a cup too low; 6. without the contraindication taking medicine of the present invention.

Traditional Chinese medical science inclusion criteria: kidney deficiency blood stasis type

Impotence, premature ejaculation, soreness of the waist and knees, body of the tongue purple is dim or have petechia, hesitant pulse CHI-pulse being weak;

1.3 method

Matched group and treatment group have all taken flaccidity tonifying YANG granule (being produced by Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin), 1 bag/time, 2 times/day, and sooner or later within 2 hours after the meal, take, March is a course for the treatment of.Treatment group adds Chinese medicine composition of the present invention (Shijiazhuang Yiling Pharmaceutical Co., Ltd's production), each 3, oral, every day 2 times.Require that patient is at period in a medicine 1 sexual life at least weekly, 6 weeks therapeutic effect of post-evaluation of taking medicine continuously.

1.4 treatment fore-and-aft observing indexs

1. IIEF-5 scoring; 2. the total testosterone of blood is measured; 3. mighty force Nocturnal penile tumescence monitor is utilized to carry out Nocturnal penile tumescence function monitoring; 4. untoward reaction.

1.5 curative effect judging standard

Take medicine continuously 6 weeks, period, under sexual stimulus condition, causes erection, completes sexual life.After 6 weeks, employing IIEF-5 questionnaire carries out erection function assessment, and scoring >21 divides or before ratio treatment of marking, rising >10 is divided into effectively; Scoring nothing changes or still the <21 person of dividing is invalid.

1.6 statistical analysis

Data SPSS11.0 software kit is analyzed, and statistical method is pairing t inspection.P<0.01 is that difference has statistical significance.

2 results

2.1 therapeutic outcomes compare

In matched group and treatment group, IIEF-5 scoring after treatment, the total testosterone levels of blood and nocturnal tumescence time penis blood volume (NPT), compared with before treatment, P<0.05, all has significant difference; IIEF-5 scoring after treatment group treatment, the total testosterone levels of blood and nocturnal tumescence time penis blood volume, compared with after treatment of control group, P<0.05, all has significant difference.Two groups of therapeutic outcomes compare in table 1.

A table 1 liang group therapeutic outcome compares

Note: with this group before treatment, ^*p<0.05; Compare with after treatment of control group, ^*p<0.05.

2.2 untoward reaction

Treatments period, does not all find obvious adverse reaction.

3 conclusions

Above clinical and experimental study shows, by Drug therapy of the present invention, patient IIEF-5 marks, the total testosterone levels of blood and nocturnal tumescence time penis blood volume all have significantly improving in various degree, and treatments period non-evident effect.Prove that Chinese medicine composition of the present invention effectively can treat kidney deficiency blood stasis type erectile dysfunction.

Claims (1)

1. the application of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine, penis blood volume when it is characterized in that improving nocturnal tumescence, described Chinese medicine composition is made by the following method:

A) crude drug formula is:

Radix Ginseng 39.6g, Hirudo 72.6g, Eupolyphaga Seu Steleophaga 46.2g, Olibanum (processed) 13.2g, Radix Paeoniae Rubra 33g, Lignum Dalbergiae Odoriferae 13.2g, Lignum Santali Albi 13.2g, Scorpio 19.8g, Periostracum Cicadae 46.2g Scolopendra 6.6g, Borneolum Syntheticum 33g, Semen Ziziphi Spinosae (parched) 33g;

B) pulverizing medicinal materials technique:

By Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and Periostracum Cicadae five kinds of worm medicines after cleaning, washing process and clean the Olibanum (processed) after the process of preparing Chinese medicine and prepare burden by prescription, pulverized by pulverizer, medicated powder fineness reaches more than 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication technique, makes medicated powder mean diameter be less than 30-40 μm; Medical material to be comminuted, after cleaning, drying sterilizing, is prepared burden;

C) concentrated and drying process is extracted:

Use water extraction again after Lignum Dalbergiae Odoriferae and the first extracting in water volatile oil of Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, each 3 hours, merge Aqueous extracts, after filtration, and one-tenth extractum to be concentrated; Radix Ginseng with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid, reclaim ethanol to hiding without alcohol, use water extraction again, it is 0.9 ~ 1.1 alcohol-extracted extract that alcohol extract is condensed into 60 DEG C of mensuration relative densities, and Aqueous extracts is concentrated into 60 DEG C after filtering and mixing with above-mentioned all Aqueous extracts and measures the clear paste that relative density is 0.9 ~ 1.1, for subsequent use;

D) preparation process:

Superfine powder flour is added, then by step c in Fluidbedgranulatingdrier) gained extracts extractum and sprays into granulation; By the granule made through granulate, add Borneolum Syntheticum fine powder, spray into the volatile oil extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by capsule filler filling after mixing, make 1000 capsules.